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Conserved domains on  [gi|24308207|ref|NP_065761|]
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leucine-rich repeat-containing protein 47 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
56-239 1.91e-35

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 138.14  E-value: 1.91e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308207  56 EVSGCGSLRAPGPGLAQGLPQLHSLVLRRNALGpGLSPELGPLPALRVLDLSGNALEALPPGQGlgpaeppGLPQLQSLN 135
Cdd:COG4886  94 DLTNLTELDLSGNEELSNLTNLESLDLSGNQLT-DLPEELANLTNLKELDLSNNQLTDLPEPLG-------NLTNLKSLD 165

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308207 136 LSGNRLRELPADLARCaPRLQSLNLTGNCLDSFPAELfrpGALPLLSELAAADNCLRELSPDIAHLASLKTLDLSNNQLS 215
Cdd:COG4886 166 LSNNQLTDLPEELGNL-TNLKELDLSNNQITDLPEPL---GNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLT 241

                       170       180
                ....*....|....*....|....
gi 24308207 216 EIPaELADCPKLKEINFRGNKLRD 239
Cdd:COG4886 242 DLP-ELGNLTNLEELDLSNNQLTD 264
pheT_arch super family cl36670
phenylalanyl-tRNA synthetase, beta subunit; Every known example of the phenylalanyl-tRNA ...
 325-515 1.61e-29

phenylalanyl-tRNA synthetase, beta subunit; Every known example of the phenylalanyl-tRNA synthetase, except the monomeric form of mitochondrial, is an alpha 2 beta 2 heterotetramer. The beta subunits break into two subfamilies that are considerably different in sequence, length, and pattern of gaps. This model represents the subfamily that includes the beta subunit from eukaryotic cytosol, the Archaea, and spirochetes. [Protein synthesis, tRNA aminoacylation]


The actual alignment was detected with superfamily member TIGR00471:

Pssm-ID: 273096 [Multi-domain]  Cd Length: 551  Bit Score: 122.94  E-value: 1.61e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308207   325 VSPEVRDVRPYIVGAVVRGMDLQPgNALKRFLTSQTKLHEDLCEKRTAATLATHELRAVKGPLLYCARPPQDLKIVPLGR 404
Cdd:TIGR00471  89 VDESVLQIRPFITGAVVKGIILND-KVLESLIELQEKLHWNIGRNRRKVAIGIHDLDKVEFPFHYKAVSPNGIKFVPLNS 167

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308207   405 -KEAKAKELVrqlqleaEEQRKQKkrqsvsglhRYLHLLDGNENYPCLVDADGDVISFPPITNSEKTKVKKTTSDLFLEV 483
Cdd:TIGR00471 168 dQEMTPDEIL-------EEHPKGI---------RYAHIIEDSDKFPLILDSKDDVLSMPPIINSELTKLTVNTRNLLIDV 231

                         170       180       190
                  ....*....|....*....|....*....|..
gi 24308207   484 TsATSLQICKDVMDALILKMAEMKKYTLENKE 515
Cdd:TIGR00471 232 T-GTDKTAVEITLNIACTMFADRGDGRITVVE 262
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
56-239 1.91e-35

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 138.14  E-value: 1.91e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308207  56 EVSGCGSLRAPGPGLAQGLPQLHSLVLRRNALGpGLSPELGPLPALRVLDLSGNALEALPPGQGlgpaeppGLPQLQSLN 135
Cdd:COG4886  94 DLTNLTELDLSGNEELSNLTNLESLDLSGNQLT-DLPEELANLTNLKELDLSNNQLTDLPEPLG-------NLTNLKSLD 165

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308207 136 LSGNRLRELPADLARCaPRLQSLNLTGNCLDSFPAELfrpGALPLLSELAAADNCLRELSPDIAHLASLKTLDLSNNQLS 215
Cdd:COG4886 166 LSNNQLTDLPEELGNL-TNLKELDLSNNQITDLPEPL---GNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLT 241

                       170       180
                ....*....|....*....|....
gi 24308207 216 EIPaELADCPKLKEINFRGNKLRD 239
Cdd:COG4886 242 DLP-ELGNLTNLEELDLSNNQLTD 264
pheT_arch TIGR00471
phenylalanyl-tRNA synthetase, beta subunit; Every known example of the phenylalanyl-tRNA ...
 325-515 1.61e-29

phenylalanyl-tRNA synthetase, beta subunit; Every known example of the phenylalanyl-tRNA synthetase, except the monomeric form of mitochondrial, is an alpha 2 beta 2 heterotetramer. The beta subunits break into two subfamilies that are considerably different in sequence, length, and pattern of gaps. This model represents the subfamily that includes the beta subunit from eukaryotic cytosol, the Archaea, and spirochetes. [Protein synthesis, tRNA aminoacylation]


Pssm-ID: 273096 [Multi-domain]  Cd Length: 551  Bit Score: 122.94  E-value: 1.61e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308207   325 VSPEVRDVRPYIVGAVVRGMDLQPgNALKRFLTSQTKLHEDLCEKRTAATLATHELRAVKGPLLYCARPPQDLKIVPLGR 404
Cdd:TIGR00471  89 VDESVLQIRPFITGAVVKGIILND-KVLESLIELQEKLHWNIGRNRRKVAIGIHDLDKVEFPFHYKAVSPNGIKFVPLNS 167

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308207   405 -KEAKAKELVrqlqleaEEQRKQKkrqsvsglhRYLHLLDGNENYPCLVDADGDVISFPPITNSEKTKVKKTTSDLFLEV 483
Cdd:TIGR00471 168 dQEMTPDEIL-------EEHPKGI---------RYAHIIEDSDKFPLILDSKDDVLSMPPIINSELTKLTVNTRNLLIDV 231

                         170       180       190
                  ....*....|....*....|....*....|..
gi 24308207   484 TsATSLQICKDVMDALILKMAEMKKYTLENKE 515
Cdd:TIGR00471 232 T-GTDKTAVEITLNIACTMFADRGDGRITVVE 262
PLN02265 PLN02265
probable phenylalanyl-tRNA synthetase beta chain
 320-512 7.81e-28

probable phenylalanyl-tRNA synthetase beta chain


Pssm-ID: 215149 [Multi-domain]  Cd Length: 597  Bit Score: 117.86  E-value: 7.81e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308207  320 PLTVRVSPEVRDVRPYIVGAVVRGM--DLQPGNAlkrFLTSQTKLHEDLCEKRTAATLATHELRAVKGPLLYCARPPQDL 397
Cdd:PLN02265 110 ILKMHVKPETSLIRPFVVCAVLRGVtfDEARYNS---FIDLQDKLHQNICRRRTLVAIGTHDLDTLQGPFTYEALPPEDI 186

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308207  398 KIVPLGR-KEAKAKELVrqlqleaEEQRKQKKrqsvsgLHRYLHLLDGNENYPCLVDADGDVISFPPITNSEKTKVKKTT 476
Cdd:PLN02265 187 NFVPLKQtKSFRADELM-------EFYKSDMK------LKKFLHIIENSPVFPVIYDSNRTVLSLPPIINGAHSAITLDT 253

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 24308207  477 SDLFLEVTsATSLQICKDVMDALILKMAEM--KKYTLE 512
Cdd:PLN02265 254 KNVFIECT-ATDLTKAKIVLNTMVTMFSEYcaRKFEVE 290
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 93-240 1.55e-14

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 72.90  E-value: 1.55e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308207  93 PELGPLPALRVLDLSGNALEALppgQGLGpaeppGLPQLQSLNLSGNRLRELpADLARCaPRLQSLNLTGNCLDSFPAEL 172
Cdd:cd21340  40 ENLEFLTNLTHLYLQNNQIEKI---ENLE-----NLVNLKKLYLGGNRISVV-EGLENL-TNLEELHIENQRLPPGEKLT 109

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308207 173 FRPGALPLLSE----LAAADNCLRELSPdIAHLASLKTLDLSNNQLSEIpAELAD----CPKLKEINFRGN------KLR 238
Cdd:cd21340 110 FDPRSLAALSNslrvLNISGNNIDSLEP-LAPLRNLEQLDASNNQISDL-EELLDllssWPSLRELDLTGNpvckkpKYR 187


                ..
gi 24308207 239 DK 240
Cdd:cd21340 188 DK 189
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 40-240 3.56e-10

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 62.94  E-value: 3.56e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308207   40 GQLPPRLftlpllhylevSGCGSLRapgpglaqglpqlhSLVLRRNALGPGLSPELGPLPALRVLDLSGNALealppgQG 119
Cdd:PLN00113 394 GEIPKSL-----------GACRSLR--------------RVRLQDNSFSGELPSEFTKLPLVYFLDISNNNL------QG 442

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308207  120 LGPAEPPGLPQLQSLNLSGNR-LRELPaDLARcAPRLQSLNLTGNCLD-SFPAELfrpGALPLLSELAAADNCLRELSPD 197
Cdd:PLN00113 443 RINSRKWDMPSLQMLSLARNKfFGGLP-DSFG-SKRLENLDLSRNQFSgAVPRKL---GSLSELMQLKLSENKLSGEIPD 517

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 24308207  198 -IAHLASLKTLDLSNNQLS-EIPAELADCPKLKEINFRGNKLRDK 240
Cdd:PLN00113 518 eLSSCKKLVSLDLSHNQLSgQIPASFSEMPVLSQLDLSQNQLSGE 562
LRR_8 pfam13855
Leucine rich repeat;
99-163 4.48e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 52.53  E-value: 4.48e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 24308207    99 PALRVLDLSGNALEALPPGQGLGpaeppgLPQLQSLNLSGNRLRELPADLARCAPRLQSLNLTGN 163
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKG------LSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGN 59
B3_4 smart00873
B3/4 domain; This domain is found in tRNA synthetase beta subunits as well as in some non tRNA ...
 333-506 4.06e-07

B3/4 domain; This domain is found in tRNA synthetase beta subunits as well as in some non tRNA synthetase proteins.


Pssm-ID: 214876 [Multi-domain]  Cd Length: 174  Bit Score: 50.34  E-value: 4.06e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308207    333 RPYIVGAVVRGmdlqPGNALKRFLTSQTKLHEDLCEKRTAATlATHELRAVKGPLLYCARPPQDL--KIVPLGRKEAKAK 410
Cdd:smart00873   1 CPRYLGRVIRG----VKNTRPSPEWLQERLHRAGIRPINNVV-DITNYVSLETGQPLHAFDLDKIkgKDIPLRRAKEGEK 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308207    411 ELVrqlqLEAEEQRKQKKRQSVSGLHRYLHLLDGNENYPCLVDADGDVISFPPITNSEKT-KVKKTTSDLFLEVTSA--- 486
Cdd:smart00873  76 FET----LDGKEYELDEGDLVIADDEGPLALAGVMGGEESEVTENTTVIFLEPAIFSPRTiRITARTLNLFTDASGRfer 151

                          170       180
                   ....*....|....*....|.
gi 24308207    487 -TSLQICKDVMDALILKMAEM 506
Cdd:smart00873 152 gVDPELVELALDRAAALLLEI 172
B3_4 pfam03483
B3/4 domain; This domain is found in tRNA synthetase beta subunits as well as in some non tRNA ...
 439-484 3.09e-04

B3/4 domain; This domain is found in tRNA synthetase beta subunits as well as in some non tRNA synthetase proteins.


Pssm-ID: 427327 [Multi-domain]  Cd Length: 174  Bit Score: 41.76  E-value: 3.09e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 24308207   439 LHLLDG-----NENYPCLVDADGdVISFPPITNSEKTKVKKTTSDLFLEVT 484
Cdd:pfam03483  76 FTTLDGkerelDPGDLVIADDDG-PVALAGIMGGEESEVTEDTTNIFLESA 125
LRR smart00370
Leucine-rich repeats, outliers;
128-148 2.09e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 35.79  E-value: 2.09e-03
                           10        20
                   ....*....|....*....|.
gi 24308207    128 LPQLQSLNLSGNRLRELPADL 148
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGA 21
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
56-239 1.91e-35

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 138.14  E-value: 1.91e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308207  56 EVSGCGSLRAPGPGLAQGLPQLHSLVLRRNALGpGLSPELGPLPALRVLDLSGNALEALPPGQGlgpaeppGLPQLQSLN 135
Cdd:COG4886  94 DLTNLTELDLSGNEELSNLTNLESLDLSGNQLT-DLPEELANLTNLKELDLSNNQLTDLPEPLG-------NLTNLKSLD 165

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308207 136 LSGNRLRELPADLARCaPRLQSLNLTGNCLDSFPAELfrpGALPLLSELAAADNCLRELSPDIAHLASLKTLDLSNNQLS 215
Cdd:COG4886 166 LSNNQLTDLPEELGNL-TNLKELDLSNNQITDLPEPL---GNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLT 241

                       170       180
                ....*....|....*....|....
gi 24308207 216 EIPaELADCPKLKEINFRGNKLRD 239
Cdd:COG4886 242 DLP-ELGNLTNLEELDLSNNQLTD 264
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
46-244 3.79e-33

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 131.59  E-value: 3.79e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308207  46 LFTLPLLHYLEVSGCgSLRAPGPGLAQgLPQLHSLVLRRNALGPgLSPELGPLPALRVLDLSGNALEALPPGqgLGpaep 125
Cdd:COG4886 109 LSNLTNLESLDLSGN-QLTDLPEELAN-LTNLKELDLSNNQLTD-LPEPLGNLTNLKSLDLSNNQLTDLPEE--LG---- 179

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308207 126 pGLPQLQSLNLSGNRLRELPADLARCaPRLQSLNLTGNCLDSFPAELfrpGALPLLSELAAADNCLRELsPDIAHLASLK 205
Cdd:COG4886 180 -NLTNLKELDLSNNQITDLPEPLGNL-TNLEELDLSGNQLTDLPEPL---ANLTNLETLDLSNNQLTDL-PELGNLTNLE 253

                       170       180       190
                ....*....|....*....|....*....|....*....
gi 24308207 206 TLDLSNNQLSEIPaELADCPKLKEINFRGNKLRDKRLEK 244
Cdd:COG4886 254 ELDLSNNQLTDLP-PLANLTNLKTLDLSNNQLTDLKLKE 291
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
72-239 9.21e-33

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 130.44  E-value: 9.21e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308207  72 QGLPQLHSLVLRRNalgpglsPELGPLPALRVLDLSGNALEALPpgqglgpAEPPGLPQLQSLNLSGNRLRELPADLARC 151
Cdd:COG4886  93 GDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDLP-------EELANLTNLKELDLSNNQLTDLPEPLGNL 158

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308207 152 aPRLQSLNLTGNCLDSFPAELfrpGALPLLSELAAADNCLRELSPDIAHLASLKTLDLSNNQLSEIPAELADCPKLKEIN 231
Cdd:COG4886 159 -TNLKSLDLSNNQLTDLPEEL---GNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLD 234


                ....*...
gi 24308207 232 FRGNKLRD 239
Cdd:COG4886 235 LSNNQLTD 242
pheT_arch TIGR00471
phenylalanyl-tRNA synthetase, beta subunit; Every known example of the phenylalanyl-tRNA ...
 325-515 1.61e-29

phenylalanyl-tRNA synthetase, beta subunit; Every known example of the phenylalanyl-tRNA synthetase, except the monomeric form of mitochondrial, is an alpha 2 beta 2 heterotetramer. The beta subunits break into two subfamilies that are considerably different in sequence, length, and pattern of gaps. This model represents the subfamily that includes the beta subunit from eukaryotic cytosol, the Archaea, and spirochetes. [Protein synthesis, tRNA aminoacylation]


Pssm-ID: 273096 [Multi-domain]  Cd Length: 551  Bit Score: 122.94  E-value: 1.61e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308207   325 VSPEVRDVRPYIVGAVVRGMDLQPgNALKRFLTSQTKLHEDLCEKRTAATLATHELRAVKGPLLYCARPPQDLKIVPLGR 404
Cdd:TIGR00471  89 VDESVLQIRPFITGAVVKGIILND-KVLESLIELQEKLHWNIGRNRRKVAIGIHDLDKVEFPFHYKAVSPNGIKFVPLNS 167

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308207   405 -KEAKAKELVrqlqleaEEQRKQKkrqsvsglhRYLHLLDGNENYPCLVDADGDVISFPPITNSEKTKVKKTTSDLFLEV 483
Cdd:TIGR00471 168 dQEMTPDEIL-------EEHPKGI---------RYAHIIEDSDKFPLILDSKDDVLSMPPIINSELTKLTVNTRNLLIDV 231

                         170       180       190
                  ....*....|....*....|....*....|..
gi 24308207   484 TsATSLQICKDVMDALILKMAEMKKYTLENKE 515
Cdd:TIGR00471 232 T-GTDKTAVEITLNIACTMFADRGDGRITVVE 262
PLN02265 PLN02265
probable phenylalanyl-tRNA synthetase beta chain
 320-512 7.81e-28

probable phenylalanyl-tRNA synthetase beta chain


Pssm-ID: 215149 [Multi-domain]  Cd Length: 597  Bit Score: 117.86  E-value: 7.81e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308207  320 PLTVRVSPEVRDVRPYIVGAVVRGM--DLQPGNAlkrFLTSQTKLHEDLCEKRTAATLATHELRAVKGPLLYCARPPQDL 397
Cdd:PLN02265 110 ILKMHVKPETSLIRPFVVCAVLRGVtfDEARYNS---FIDLQDKLHQNICRRRTLVAIGTHDLDTLQGPFTYEALPPEDI 186

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308207  398 KIVPLGR-KEAKAKELVrqlqleaEEQRKQKKrqsvsgLHRYLHLLDGNENYPCLVDADGDVISFPPITNSEKTKVKKTT 476
Cdd:PLN02265 187 NFVPLKQtKSFRADELM-------EFYKSDMK------LKKFLHIIENSPVFPVIYDSNRTVLSLPPIINGAHSAITLDT 253

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 24308207  477 SDLFLEVTsATSLQICKDVMDALILKMAEM--KKYTLE 512
Cdd:PLN02265 254 KNVFIECT-ATDLTKAKIVLNTMVTMFSEYcaRKFEVE 290
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
42-231 8.70e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 76.51  E-value: 8.70e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308207  42 LPPRLFTLPLLHYLEVSGCgSLRAPGPGLAQgLPQLHSLVLRRNALGPgLSPELGPLPALRVLDLSGNALEALPpgqGLG 121
Cdd:COG4886 174 LPEELGNLTNLKELDLSNN-QITDLPEPLGN-LTNLEELDLSGNQLTD-LPEPLANLTNLETLDLSNNQLTDLP---ELG 247

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308207 122 paeppGLPQLQSLNLSGNRLRELPADLArcAPRLQSLNLTGNCLDSFP-AELFRPGALPLLSELAAADNCLRELSPDIAH 200
Cdd:COG4886 248 -----NLTNLEELDLSNNQLTDLPPLAN--LTNLKTLDLSNNQLTDLKlKELELLLGLNSLLLLLLLLNLLELLILLLLL 320

                       170       180       190
                ....*....|....*....|....*....|.
gi 24308207 201 LASLKTLDLSNNQLSEIPAELADCPKLKEIN 231
Cdd:COG4886 321 TTLLLLLLLLKGLLVTLTTLALSLSLLALLT 351
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 93-240 1.55e-14

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 72.90  E-value: 1.55e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308207  93 PELGPLPALRVLDLSGNALEALppgQGLGpaeppGLPQLQSLNLSGNRLRELpADLARCaPRLQSLNLTGNCLDSFPAEL 172
Cdd:cd21340  40 ENLEFLTNLTHLYLQNNQIEKI---ENLE-----NLVNLKKLYLGGNRISVV-EGLENL-TNLEELHIENQRLPPGEKLT 109

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308207 173 FRPGALPLLSE----LAAADNCLRELSPdIAHLASLKTLDLSNNQLSEIpAELAD----CPKLKEINFRGN------KLR 238
Cdd:cd21340 110 FDPRSLAALSNslrvLNISGNNIDSLEP-LAPLRNLEQLDASNNQISDL-EELLDllssWPSLRELDLTGNpvckkpKYR 187


                ..
gi 24308207 239 DK 240
Cdd:cd21340 188 DK 189
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 40-240 3.56e-10

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 62.94  E-value: 3.56e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308207   40 GQLPPRLftlpllhylevSGCGSLRapgpglaqglpqlhSLVLRRNALGPGLSPELGPLPALRVLDLSGNALealppgQG 119
Cdd:PLN00113 394 GEIPKSL-----------GACRSLR--------------RVRLQDNSFSGELPSEFTKLPLVYFLDISNNNL------QG 442

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308207  120 LGPAEPPGLPQLQSLNLSGNR-LRELPaDLARcAPRLQSLNLTGNCLD-SFPAELfrpGALPLLSELAAADNCLRELSPD 197
Cdd:PLN00113 443 RINSRKWDMPSLQMLSLARNKfFGGLP-DSFG-SKRLENLDLSRNQFSgAVPRKL---GSLSELMQLKLSENKLSGEIPD 517

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 24308207  198 -IAHLASLKTLDLSNNQLS-EIPAELADCPKLKEINFRGNKLRDK 240
Cdd:PLN00113 518 eLSSCKKLVSLDLSHNQLSgQIPASFSEMPVLSQLDLSQNQLSGE 562
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
93-237 1.31e-09

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 61.25  E-value: 1.31e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308207   93 PELGPlPALRVLDLSGNALEALppgqglgpaePPGLPQ-LQSLNLSGNRLRELPADLARcapRLQSLNLTGNCLDSFPAE 171
Cdd:PRK15370 257 PERLP-SALQSLDLFHNKISCL----------PENLPEeLRYLSVYDNSIRTLPAHLPS---GITHLNVQSNSLTALPET 322

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 24308207  172 LfrPgalPLLSELAAADNCLRELSPDIAhlASLKTLDLSNNQLSEIPAELAdcPKLKEINFRGNKL 237
Cdd:PRK15370 323 L--P---PGLKTLEAGENALTSLPASLP--PELQVLDVSKNQITVLPETLP--PTITTLDVSRNAL 379
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 69-254 2.68e-09

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 59.42  E-value: 2.68e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308207  69 GLAQGL---PQLHSLVLRRNALGPGLSPELGP----LPALRVLDLSGNAL---------EALPPGQglgpaeppglpQLQ 132
Cdd:COG5238 199 ELAEALtqnTTVTTLWLKRNPIGDEGAEILAEalkgNKSLTTLDLSNNQIgdegvialaEALKNNT-----------TVE 267

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308207 133 SLNLSGNRLRE----LPADLARCAPRLQSLNLTGNCLDSfpaelfrPGALPL---------LSELAAADNCLRE-----L 194
Cdd:COG5238 268 TLYLSGNQIGAegaiALAKALQGNTTLTSLDLSVNRIGD-------EGAIALaeglqgnktLHTLNLAYNGIGAqgaiaL 340

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 24308207 195 SPDIAHLASLKTLDLSNNQLSEIPAE-----LADCPKLKEINFRGNKLRDKRLEKMVSGCQTRSI 254
Cdd:COG5238 341 AKALQENTTLHSLDLSDNQIGDEGAIalakyLEGNTTLRELNLGKNNIGKQGAEALIDALQTNRL 405
LRR_8 pfam13855
Leucine rich repeat;
99-163 4.48e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 52.53  E-value: 4.48e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 24308207    99 PALRVLDLSGNALEALPPGQGLGpaeppgLPQLQSLNLSGNRLRELPADLARCAPRLQSLNLTGN 163
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKG------LSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGN 59
LRR_8 pfam13855
Leucine rich repeat;
75-141 8.98e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 51.76  E-value: 8.98e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24308207    75 PQLHSLVLRRNALGpGLSPE-LGPLPALRVLDLSGNALEALPPGQGLGpaeppgLPQLQSLNLSGNRL 141
Cdd:pfam13855   1 PNLRSLDLSNNRLT-SLDDGaFKGLSNLKVLDLSNNLLTTLSPGAFSG------LPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 62-258 1.13e-08

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 56.98  E-value: 1.13e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308207  62 SLRAPGPGLaQGLPQLHSLVLRRNALGPGLSPELGPL---PALRVLDLSGNALEALPpGQGLGPAEPPGLPQLQSLNLSG 138
Cdd:cd00116  69 GLQSLLQGL-TKGCGLQELDLSDNALGPDGCGVLESLlrsSSLQELKLNNNGLGDRG-LRLLAKGLKDLPPALEKLVLGR 146

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308207 139 NRL-----RELpADLARCAPRLQSLNLTGNCLDSFPAELFRPG--ALPLLSELAAADNCLRE-----LSPDIAHLASLKT 206
Cdd:cd00116 147 NRLegascEAL-AKALRANRDLKELNLANNGIGDAGIRALAEGlkANCNLEVLDLNNNGLTDegasaLAETLASLKSLEV 225

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 24308207 207 LDLSNNQLSEIP-AELAD-----CPKLKEINFRGNKLRDKRLEKMVSGCQTRSILEYL 258
Cdd:cd00116 226 LNLGDNNLTDAGaAALASallspNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLEL 283
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 40-237 3.78e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 56.39  E-value: 3.78e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308207   40 GQLPP---RLFTLPLLHYLEVSGCGSLrapgPGLAQGLPQLHSLVLRRNALGPGLSPELGPLPALRVLDLSGNALEALPP 116
Cdd:PLN00113 298 GEIPElviQLQNLEILHLFSNNFTGKI----PVALTSLPRLQVLQLWSNKFSGEIPKNLGKHNNLTVLDLSTNNLTGEIP 373

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308207  117 gQGLGPAeppglPQLQSLNLSGNRLR-ELPADLARCAP----RLQSLNLTGNCLDSF---PAELF--------------R 174
Cdd:PLN00113 374 -EGLCSS-----GNLFKLILFSNSLEgEIPKSLGACRSlrrvRLQDNSFSGELPSEFtklPLVYFldisnnnlqgrinsR 447

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 24308207  175 PGALPLLSELAAADNCLRELSPDIAHLASLKTLDLSNNQLSE-IPAELADCPKLKEINFRGNKL 237
Cdd:PLN00113 448 KWDMPSLQMLSLARNKFFGGLPDSFGSKRLENLDLSRNQFSGaVPRKLGSLSELMQLKLSENKL 511
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
70-245 5.44e-08

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 55.86  E-value: 5.44e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308207   70 LAQGLPQ-LHSLVLRRNALG--PGLSPElgplpALRVLDLSGNALEALPPGQGLGPAE-----------PPGLP-QLQSL 134
Cdd:PRK15370 256 LPERLPSaLQSLDLFHNKISclPENLPE-----ELRYLSVYDNSIRTLPAHLPSGITHlnvqsnsltalPETLPpGLKTL 330

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308207  135 NLSGNRLRELPADLArcaPRLQSLNLTGNCLDSFPAELfrPgalPLLSELAAADNCLRELSPDIAhlASLKTLDLSNNQL 214
Cdd:PRK15370 331 EAGENALTSLPASLP---PELQVLDVSKNQITVLPETL--P---PTITTLDVSRNALTNLPENLP--AALQIMQASRNNL 400

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 24308207  215 SEIPAEL----ADCPKLKEINFRGNKLRDKRLEKM 245
Cdd:PRK15370 401 VRLPESLphfrGEGPQPTRIIVEYNPFSERTIQNM 435
LRR_8 pfam13855
Leucine rich repeat;
129-214 6.00e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.45  E-value: 6.00e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308207   129 PQLQSLNLSGNRLRELPADLARCAPRLQSLNLTGNCLDSFPAELFrpgalpllselaaadnclrelspdiAHLASLKTLD 208
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAF-------------------------SGLPSLRYLD 55


                  ....*.
gi 24308207   209 LSNNQL 214
Cdd:pfam13855  56 LSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 127-237 1.79e-07

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 54.47  E-value: 1.79e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308207  127 GLPQLQSLNLSGNRLR-ELPADLARCAPRLQSLNLTGNcldSFPAELFRpGALPLLSELAAADNCLR-ELSPDIAHLASL 204
Cdd:PLN00113  91 RLPYIQTINLSNNQLSgPIPDDIFTTSSSLRYLNLSNN---NFTGSIPR-GSIPNLETLDLSNNMLSgEIPNDIGSFSSL 166

                         90       100       110
                 ....*....|....*....|....*....|....
gi 24308207  205 KTLDLSNNQLS-EIPAELADCPKLKEINFRGNKL 237
Cdd:PLN00113 167 KVLDLGGNVLVgKIPNSLTNLTSLEFLTLASNQL 200
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 40-237 2.37e-07

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 54.08  E-value: 2.37e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308207   40 GQLPPRLFTLPL-LHYLEVSGcGSLRAPGPGlaQGLPQLHSLVLRRNALGPGLSPELGPLPALRVLDLSGNALealppgQ 118
Cdd:PLN00113 107 GPIPDDIFTTSSsLRYLNLSN-NNFTGSIPR--GSIPNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVL------V 177

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308207  119 GLGPAEPPGLPQLQSLNLSGNRLR-ELPADLArcapRLQSL--------NLTGncldSFPAELfrpGALPLLSELAAADN 189
Cdd:PLN00113 178 GKIPNSLTNLTSLEFLTLASNQLVgQIPRELG----QMKSLkwiylgynNLSG----EIPYEI---GGLTSLNHLDLVYN 246

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 24308207  190 CLR-ELSPDIAHLASLKTLDLSNNQLS-EIPAELADCPKLKEINFRGNKL 237
Cdd:PLN00113 247 NLTgPIPSSLGNLKNLQYLFLYQNKLSgPIPPSIFSLQKLISLDLSDNSL 296
B3_4 smart00873
B3/4 domain; This domain is found in tRNA synthetase beta subunits as well as in some non tRNA ...
 333-506 4.06e-07

B3/4 domain; This domain is found in tRNA synthetase beta subunits as well as in some non tRNA synthetase proteins.


Pssm-ID: 214876 [Multi-domain]  Cd Length: 174  Bit Score: 50.34  E-value: 4.06e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308207    333 RPYIVGAVVRGmdlqPGNALKRFLTSQTKLHEDLCEKRTAATlATHELRAVKGPLLYCARPPQDL--KIVPLGRKEAKAK 410
Cdd:smart00873   1 CPRYLGRVIRG----VKNTRPSPEWLQERLHRAGIRPINNVV-DITNYVSLETGQPLHAFDLDKIkgKDIPLRRAKEGEK 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308207    411 ELVrqlqLEAEEQRKQKKRQSVSGLHRYLHLLDGNENYPCLVDADGDVISFPPITNSEKT-KVKKTTSDLFLEVTSA--- 486
Cdd:smart00873  76 FET----LDGKEYELDEGDLVIADDEGPLALAGVMGGEESEVTENTTVIFLEPAIFSPRTiRITARTLNLFTDASGRfer 151

                          170       180
                   ....*....|....*....|.
gi 24308207    487 -TSLQICKDVMDALILKMAEM 506
Cdd:smart00873 152 gVDPELVELALDRAAALLLEI 172
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 74-240 1.12e-06

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 50.82  E-value: 1.12e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308207  74 LPQLHSLVLRRNALG----PGLSPELGPLPALRVLDLSGNALEALPPGQGLGPAEPPGLPQLQSLNLSGNRL-RELPADL 148
Cdd:cd00116  22 LLCLQVLRLEGNTLGeeaaKALASALRPQPSLKELCLSLNETGRIPRGLQSLLQGLTKGCGLQELDLSDNALgPDGCGVL 101

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308207 149 ARC--APRLQSLNLTGNCLDSFPAELFRPGALPL---LSELAAADN-----CLRELSPDIAHLASLKTLDLSNNQLSE-- 216
Cdd:cd00116 102 ESLlrSSSLQELKLNNNGLGDRGLRLLAKGLKDLppaLEKLVLGRNrlegaSCEALAKALRANRDLKELNLANNGIGDag 181

                       170       180
                ....*....|....*....|....*..
gi 24308207 217 IPA---ELADCPKLKEINFRGNKLRDK 240
Cdd:cd00116 182 IRAlaeGLKANCNLEVLDLNNNGLTDE 208
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
70-254 1.67e-06

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 50.93  E-value: 1.67e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308207   70 LAQGLP-QLHSLVLRRNALG--PGLSPELgplpalRVLDLSGN---ALEALPPG----------QGLGPAEPPGLPQLQs 133
Cdd:PRK15387 216 LPDCLPaHITTLVIPDNNLTslPALPPEL------RTLEVSGNqltSLPVLPPGllelsifsnpLTHLPALPSGLCKLW- 288

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308207  134 lnLSGNRLRELPAdlarCAPRLQSLNLTGNCLDSFPA---ELFRPGAL-PLLSELAAADNCLRELSPDIAHLASLKTLDL 209
Cdd:PRK15387 289 --IFGNQLTSLPV----LPPGLQELSVSDNQLASLPAlpsELCKLWAYnNQLTSLPTLPSGLQELSVSDNQLASLPTLPS 362

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 24308207  210 S-------NNQLSEIPAELADcpkLKEINFRGNKLRDKRL------EKMVSGCQTRSI 254
Cdd:PRK15387 363 ElyklwayNNRLTSLPALPSG---LKELIVSGNRLTSLPVlpselkELMVSGNRLTSL 417
LRR_8 pfam13855
Leucine rich repeat;
153-237 1.89e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.21  E-value: 1.89e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308207   153 PRLQSLNLTGNCLDSFPAELFRpgalpllselaaadnclrelspdiaHLASLKTLDLSNNQLSEI-PAELADCPKLKEIN 231
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFK-------------------------GLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLD 55


                  ....*.
gi 24308207   232 FRGNKL 237
Cdd:pfam13855  56 LSGNRL 61
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 203-240 1.30e-05

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 42.23  E-value: 1.30e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 24308207   203 SLKTLDLSNNQLSEIPAeLADCPKLKEINFRGNKLRDK 240
Cdd:pfam12799   2 NLEVLDLSNNQITDIPP-LAKLPNLETLDLSGNNKITD 38
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 40-237 4.77e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 46.38  E-value: 4.77e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308207   40 GQLPPRLFTLPLLHYLEVSgCGSLRAPGPGLAQGLPQLHSLVLRRNALGPGLSPELGPLPALRVLDLSGNALEALPPG-- 117
Cdd:PLN00113 226 GEIPYEIGGLTSLNHLDLV-YNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLSGEIPElv 304

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308207  118 ----------------QGLGPAEPPGLPQLQSLNLSGNRLR-ELPADLARcAPRLQSLNLTGNCLDS-FPAELFRPGAlp 179
Cdd:PLN00113 305 iqlqnleilhlfsnnfTGKIPVALTSLPRLQVLQLWSNKFSgEIPKNLGK-HNNLTVLDLSTNNLTGeIPEGLCSSGN-- 381

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308207  180 lLSELAAADNCLR-ELSPDIAHLASLKTLDLSNNQLS-EIPAELADCPKLKEINFRGNKL 237
Cdd:PLN00113 382 -LFKLILFSNSLEgEIPKSLGACRSLRRVRLQDNSFSgELPSEFTKLPLVYFLDISNNNL 440
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
42-223 1.86e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 44.15  E-value: 1.86e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308207  42 LPPRLFTLPLLHYLEVSGCG--SLrapgPGLAQgLPQLHSLVLRRNALGpGLsPELGPLPALRVLDLSGNALEALppgQG 119
Cdd:COG4886 220 LPEPLANLTNLETLDLSNNQltDL----PELGN-LTNLEELDLSNNQLT-DL-PPLANLTNLKTLDLSNNQLTDL---KL 289

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308207 120 LGPAEPPGLPQLQSLNLSGNRLRELPADLARCAPRLQSLNLTGNCLDSFPAELFRPGALPLLSELAAADNCLRELSPDIA 199
Cdd:COG4886 290 KELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTL 369

                       170       180
                ....*....|....*....|....
gi 24308207 200 HLASLKTLDLSNNQLSEIPAELAD 223
Cdd:COG4886 370 GLLGLLEATLLTLALLLLTLLLLL 393
LRR_8 pfam13855
Leucine rich repeat;
50-111 2.62e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.04  E-value: 2.62e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 24308207    50 PLLHYLEVSgCGSLRAPGPGLAQGLPQLHSLVLRRNALgPGLSPE-LGPLPALRVLDLSGNAL 111
Cdd:pfam13855   1 PNLRSLDLS-NNRLTSLDDGAFKGLSNLKVLDLSNNLL-TTLSPGaFSGLPSLRYLDLSGNRL 61
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
42-245 2.79e-04

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 44.00  E-value: 2.79e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308207   42 LPPRLFTLpllhylEVSG--CGSLRAPGPGLAQ---------GLPQLHSLVLRRNALGPGLSPELGPLPALRVLDLSGNA 110
Cdd:PRK15387 240 LPPELRTL------EVSGnqLTSLPVLPPGLLElsifsnpltHLPALPSGLCKLWIFGNQLTSLPVLPPGLQELSVSDNQ 313

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308207  111 LEALPPGqglgPAEP-------------PGLPQ-LQSLNLSGNRLRELPAdlarCAPRLQSLNLTGNCLDSFPA------ 170
Cdd:PRK15387 314 LASLPAL----PSELcklwaynnqltslPTLPSgLQELSVSDNQLASLPT----LPSELYKLWAYNNRLTSLPAlpsglk 385

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308207  171 ELFRPG----ALPLL----SELAAADNCLRELsPDIAhlASLKTLDLSNNQLSEIPAELADCPKLKEINFRGNKLRDKRL 242
Cdd:PRK15387 386 ELIVSGnrltSLPVLpselKELMVSGNRLTSL-PMLP--SGLLSLSVYRNQLTRLPESLIHLSSETTVNLEGNPLSERTL 462


                 ...
gi 24308207  243 EKM 245
Cdd:PRK15387 463 QAL 465
B3_4 pfam03483
B3/4 domain; This domain is found in tRNA synthetase beta subunits as well as in some non tRNA ...
 439-484 3.09e-04

B3/4 domain; This domain is found in tRNA synthetase beta subunits as well as in some non tRNA synthetase proteins.


Pssm-ID: 427327 [Multi-domain]  Cd Length: 174  Bit Score: 41.76  E-value: 3.09e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 24308207   439 LHLLDG-----NENYPCLVDADGdVISFPPITNSEKTKVKKTTSDLFLEVT 484
Cdd:pfam03483  76 FTTLDGkerelDPGDLVIADDDG-PVALAGIMGGEESEVTEDTTNIFLESA 125
PLN03150 PLN03150
hypothetical protein; Provisional
 118-221 4.39e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 43.27  E-value: 4.39e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308207  118 QGLGPAEPPGLPQLQSLNLSGNRLR-ELPADLARcAPRLQSLNLTGNCLD-SFPAELfrpgalpllselaaadnclrels 195
Cdd:PLN03150 431 RGFIPNDISKLRHLQSINLSGNSIRgNIPPSLGS-ITSLEVLDLSYNSFNgSIPESL----------------------- 486

                         90       100
                 ....*....|....*....|....*..
gi 24308207  196 pdiAHLASLKTLDLSNNQLS-EIPAEL 221
Cdd:PLN03150 487 ---GQLTSLRILNLNGNSLSgRVPAAL 510
PLN03150 PLN03150
hypothetical protein; Provisional
 134-237 5.35e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 42.88  E-value: 5.35e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24308207  134 LNLSGNRLR-ELPADLARCApRLQSLNLTGNCLDsfpaelfrpGALPllselaaadnclrelsPDIAHLASLKTLDLSNN 212
Cdd:PLN03150 423 LGLDNQGLRgFIPNDISKLR-HLQSINLSGNSIR---------GNIP----------------PSLGSITSLEVLDLSYN 476

                         90       100
                 ....*....|....*....|....*.
gi 24308207  213 QLS-EIPAELADCPKLKEINFRGNKL 237
Cdd:PLN03150 477 SFNgSIPESLGQLTSLRILNLNGNSL 502
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 99-141 1.04e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 37.22  E-value: 1.04e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 24308207    99 PALRVLDLSGNALEALPPgqglgpaePPGLPQLQSLNLSGNRL 141
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPP--------LAKLPNLETLDLSGNNK 35
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 129-163 1.31e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 36.84  E-value: 1.31e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 24308207   129 PQLQSLNLSGNRLRELPAdLARCaPRLQSLNLTGN 163
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPP-LAKL-PNLETLDLSGN 33
LRR smart00370
Leucine-rich repeats, outliers;
128-148 2.09e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 35.79  E-value: 2.09e-03
                           10        20
                   ....*....|....*....|.
gi 24308207    128 LPQLQSLNLSGNRLRELPADL 148
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGA 21
LRR_TYP smart00369
Leucine-rich repeats, typical (most populated) subfamily;
128-148 2.09e-03

Leucine-rich repeats, typical (most populated) subfamily;


Pssm-ID: 197687 [Multi-domain]  Cd Length: 24  Bit Score: 35.79  E-value: 2.09e-03
                           10        20
                   ....*....|....*....|.
gi 24308207    128 LPQLQSLNLSGNRLRELPADL 148
Cdd:smart00369   1 LPNLRELDLSNNQLSSLPPGA 21
LRR smart00370
Leucine-rich repeats, outliers;
201-221 2.18e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 35.79  E-value: 2.18e-03
                           10        20
                   ....*....|....*....|.
gi 24308207    201 LASLKTLDLSNNQLSEIPAEL 221
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGA 21
LRR_TYP smart00369
Leucine-rich repeats, typical (most populated) subfamily;
201-221 2.18e-03

Leucine-rich repeats, typical (most populated) subfamily;


Pssm-ID: 197687 [Multi-domain]  Cd Length: 24  Bit Score: 35.79  E-value: 2.18e-03
                           10        20
                   ....*....|....*....|.
gi 24308207    201 LASLKTLDLSNNQLSEIPAEL 221
Cdd:smart00369   1 LPNLRELDLSNNQLSSLPPGA 21
LRR smart00370
Leucine-rich repeats, outliers;
98-117 5.16e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 34.63  E-value: 5.16e-03
                           10        20
                   ....*....|....*....|
gi 24308207     98 LPALRVLDLSGNALEALPPG 117
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPG 20
LRR_TYP smart00369
Leucine-rich repeats, typical (most populated) subfamily;
98-117 5.16e-03

Leucine-rich repeats, typical (most populated) subfamily;


Pssm-ID: 197687 [Multi-domain]  Cd Length: 24  Bit Score: 34.63  E-value: 5.16e-03
                           10        20
                   ....*....|....*....|
gi 24308207     98 LPALRVLDLSGNALEALPPG 117
Cdd:smart00369   1 LPNLRELDLSNNQLSSLPPG 20
LRR_8 pfam13855
Leucine rich repeat;
203-238 9.91e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 34.81  E-value: 9.91e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 24308207   203 SLKTLDLSNNQLSEIPAE-LADCPKLKEINFRGNKLR 238
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGaFKGLSNLKVLDLSNNLLT 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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