|
Name |
Accession |
Description |
Interval |
E-value |
| 2A1904 |
TIGR00927 |
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ... |
90-629 |
6.03e-108 |
|
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273344 [Multi-domain] Cd Length: 1096 Bit Score: 350.83 E-value: 6.03e-108
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31563526 90 PALH---EFPNDIFTNEDRRQGAVVLHVLCAIYMFYALAIVCDDFFVPSLEKICERLHLSEDVAGATFMAAGSSAPELFT 166
Cdd:TIGR00927 434 PDLHpkaEYPPDLFSVEERRQGWVVLHIFGMMYVFVALAIVCDEYFVPALGVITDKLQISEDVAGATFMAAGGSAPELFT 513
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31563526 167 SVIGVFITKGDVGVGTIVGSAVFNILCIIGVCGLFAGQVVALSSWCLLRDSIYYTLSVIALIVFIYDEKVSWWESLVLVL 246
Cdd:TIGR00927 514 SLIGVFISHSNVGIGTIVGSAVFNILFVIGTCALFSREILNLTWWPLFRDVSFYILDLMMLILFFLDSLIAWWESLLLLL 593
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31563526 247 MYLIYIVIMKYNACIH----QCFERR-----------TKGA-------GNMVNGLAN-----NAEIDDSSNCDA------ 293
Cdd:TIGR00927 594 AYALYVFTMKWNKQIElwvkEQLSRRpvakvmalgdlSKGDvaeaehtGERTGEEGErpteaEGENGEESGGEAeqeget 673
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31563526 294 -TVVLLK---------------KANFHRKASVIMVDELLSAYPHQLSFSEAGLRimITSHFPPKTRLSMASRMLINERQ- 356
Cdd:TIGR00927 674 eTKGENEsegeipaerkgeqegEGEIEAKEADHKGETEAEEVEHEGETEAEGTE--DEGEIETGEEGEEVEDEGEGEAEg 751
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31563526 357 RLINSRAYTNGESEVAIKIPIKHTVENGTGPSSAPDRG-VNGTRRDDVVAEAGNETENENEDNENDEEEEEDEDDDEGPY 435
Cdd:TIGR00927 752 KHEVETEGDRKETEHEGETEAEGKEDEDEGEIQAGEDGeMKGDEGAEGKVEHEGETEAGEKDEHEGQSETQADDTEVKDE 831
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31563526 436 T--------------------------------------------------------------PFDTPSGKLETVKWAFT 453
Cdd:TIGR00927 832 TgeqelnaenqgeakqdekgvdggggsdggdseeeeeeeeeeeeeeeeeeeeeeeeeeneeplSLEWPETRQKQAIYLFL 911
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31563526 454 WPLSFVLYFTVPNCNKPRWEKWFMVTFASSTLWIAAFSYMMVWMVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVA 533
Cdd:TIGR00927 912 LPIVFPLWLTVPDVRRQEARKFFVITFLGSIMWIAMFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVA 991
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31563526 534 RQGMGDMAVSNSIGSNVFDILIGLGLPWALQTLaVDYGSYIRLNSRGLIYSVGLLLASVFVTVFGVHLNKWQLDKKLGCG 613
Cdd:TIGR00927 992 RKGLGDMAVSSSVGSNIFDITVGLPVPWLLFSL-INGLQPVPVSSNGLFCAIVLLFLMLLFVISSIASCKWRMNKILGFT 1070
|
650
....*....|....*.
gi 31563526 614 CLLLYGVFLCFSIMTE 629
Cdd:TIGR00927 1071 MFLLYFVFLIISVMLE 1086
|
|
| ECM27 |
COG0530 |
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; |
130-624 |
5.12e-34 |
|
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
Pssm-ID: 440296 [Multi-domain] Cd Length: 293 Bit Score: 131.41 E-value: 5.12e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31563526 130 DFFVPSLEKICERLHLSEDVAGATFMAAGSSAPELFTSVIGVFITKGDVGVGTIVGSAVFNILCIIGVCGLFAGqvVALS 209
Cdd:COG0530 2 DLLVRGADALARRLGISPLVIGLTIVAFGTSLPELAVSVTAALDGSPDIAVGNVVGSNIANILLILGLAALIRP--LAVD 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31563526 210 SWCLLRDSIYYTLSVIALIVFIYDEKVSWWESLVLVLMYLIYIVimkynacihqcferrtkgagnmvnglannaeiddss 289
Cdd:COG0530 80 RRVLRRDLPFLLLASLLLLALLLDGTLSRIDGVILLLLYVLYLY------------------------------------ 123
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31563526 290 ncdatvvllkkanfhrkasvimvdellsayphqlsfseaglrimitshfppktrlsmasRMLINERQRlinsraytnges 369
Cdd:COG0530 124 -----------------------------------------------------------YLIRRARKE------------ 132
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31563526 370 evaikipikhtvengtgpssapdrgvngtRRDDVVAEagnetenenednendeeeeededddegpytpfDTPSGKLETVK 449
Cdd:COG0530 133 -----------------------------PAWEEVEE--------------------------------ELEEKPKMSLW 151
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31563526 450 WAFTWplsfvlyftvpncnkprwekwfmvtFASSTLWIAAFSYMMVWMVTIIGYTLGIPDVIMGITFLAAGTSVPDCMAS 529
Cdd:COG0530 152 KALLL-------------------------LVLGLALLVVGARLLVDGAVEIARALGVSELVIGLTIVAIGTSLPELATS 206
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31563526 530 LIVARQGMGDMAVSNSIGSNVFDILIGLGLPWALQTLAVDYGSYIRLnsrgliySVGLLLASVFVTVFGvhLNKWQLDKK 609
Cdd:COG0530 207 IVAARKGEDDLAVGNIIGSNIFNILLVLGIGALITPIPVDPAVLSFD-------LPVMLAATLLLLGLL--RTGGRIGRW 277
|
490
....*....|....*
gi 31563526 610 LGCGCLLLYGVFLCF 624
Cdd:COG0530 278 EGLLLLALYLAYLAL 292
|
|
| Na_Ca_ex |
pfam01699 |
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral ... |
113-255 |
9.82e-28 |
|
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.
Pssm-ID: 426387 [Multi-domain] Cd Length: 149 Bit Score: 108.84 E-value: 9.82e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31563526 113 HVLCAIYMFYALAIVCDDFFVPSLEKICERLHLSEDVAGATFMAAGSSAPELFTSVIGVFITKGDVGVGTIVGSAVFNIL 192
Cdd:pfam01699 1 LSLLLFILGLLLISVAADLLVDSAEVLARVLGISGTVLGLTILALGTSLPELVSSIIAALRGEPDLALGNVIGSNIFNIL 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 31563526 193 CIIGVCGLFAGQVVALS----SWCLLRDSIYYTLSVIALIVFIYDEKVSWWESLVLVLMYLIYIVIM 255
Cdd:pfam01699 81 LVLGLSALIGPVKVDSLllklDLGVLLLVALLLLLLLLLLLLPLFGRLSRFEGLVLLLLYIVYLVFQ 147
|
|
| PLN03151 |
PLN03151 |
cation/calcium exchanger; Provisional |
108-638 |
1.39e-17 |
|
cation/calcium exchanger; Provisional
Pssm-ID: 215604 [Multi-domain] Cd Length: 650 Bit Score: 86.74 E-value: 1.39e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31563526 108 GAVVLHVlCAIYMFYALAIVCDDFFVPSLEKICERLHLSEDVAGATFMAAGSSAPELFTSvIGVFITK--GDVGVGTIVG 185
Cdd:PLN03151 139 GYAVLGV-WLVALFYLLGNTAADYFCCSLEKLSKLLRLPPTVAGVTLLPLGNGAPDVFAS-IAAFVGKdaGEVGLNSVLG 216
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31563526 186 SAVFNILCIIGVCGL-FAGQVVALSSWCLLRDSIYYTLSVIALIVFIYDEKVSWWESLVLVLMYLIYIVIMKYNAcIHQC 264
Cdd:PLN03151 217 GAVFVTCVVVGIVSLcVADKEVQIDKRCFIRDLCFFLFTLVSLLVILMVGKVTVGGAIAFVSIYVVYAFLVAANE-ILRK 295
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31563526 265 FERRTKgagnmvnglannaeiddssnCDATVVLLKKANFHRKASvimVDELLSAYPHQL-SFSEAGlrimitshfPPKTR 343
Cdd:PLN03151 296 HARRLK--------------------LDVVTPLLPVQGSIFSPS---VEEDESMYSPLLeSDTESD---------VPRLQ 343
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31563526 344 LSMASRMLinerqrlinsraytngESEVAIKipIKHTVENGTGPSSAPDRGVNgtrrdDVVAEAGNETENENEDNENDEE 423
Cdd:PLN03151 344 TSLPQWMW----------------ASNVAIY--SNHFAKGSVHDEERPPWGWT-----DEGAEVESSLFSCSKLFSLLEM 400
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31563526 424 EEEDEDDDEGPYT-------PFDTPSGKLETVKWAFTW-----------------------PLSFVLY-FTVPNcNKPR- 471
Cdd:PLN03151 401 PLTIPRRLTIPIVeedrwskTYAVASASLAPVLLAFLWssqddvslqariaayfigvaigsTLGFLAYkYTEPD-RPPRr 479
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31563526 472 -WEKWFMVTFASSTLWIAAFSYMMVWMVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGmGD---MAVSNSIG 547
Cdd:PLN03151 480 fLIPWVLGGFIMSIVWFYMIANELVALLVAFGVIFGINPSILGLTVLAWGNSMGDLMSNVALAMNG-GDgvqIAMSGCYA 558
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31563526 548 SNVFDILIGLGLPWALQTLAVDYGSYIRLNSRGLIYSVGLLLASVFVTVFGVHLNKWQLDKKLGCGCLLLYGVFLCFSIM 627
Cdd:PLN03151 559 GPMFNTLVGLGMSMLLGAWSKSPESYMLPEDSSLFYTMGFLVSGLIWALVVLPRNDMRPNKTLGVGLIALYLIFLTFRVS 638
|
570
....*....|.
gi 31563526 628 TEFNVFTFVNL 638
Cdd:PLN03151 639 TAMGFIPWAGL 649
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| 2A1904 |
TIGR00927 |
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ... |
90-629 |
6.03e-108 |
|
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273344 [Multi-domain] Cd Length: 1096 Bit Score: 350.83 E-value: 6.03e-108
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31563526 90 PALH---EFPNDIFTNEDRRQGAVVLHVLCAIYMFYALAIVCDDFFVPSLEKICERLHLSEDVAGATFMAAGSSAPELFT 166
Cdd:TIGR00927 434 PDLHpkaEYPPDLFSVEERRQGWVVLHIFGMMYVFVALAIVCDEYFVPALGVITDKLQISEDVAGATFMAAGGSAPELFT 513
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31563526 167 SVIGVFITKGDVGVGTIVGSAVFNILCIIGVCGLFAGQVVALSSWCLLRDSIYYTLSVIALIVFIYDEKVSWWESLVLVL 246
Cdd:TIGR00927 514 SLIGVFISHSNVGIGTIVGSAVFNILFVIGTCALFSREILNLTWWPLFRDVSFYILDLMMLILFFLDSLIAWWESLLLLL 593
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31563526 247 MYLIYIVIMKYNACIH----QCFERR-----------TKGA-------GNMVNGLAN-----NAEIDDSSNCDA------ 293
Cdd:TIGR00927 594 AYALYVFTMKWNKQIElwvkEQLSRRpvakvmalgdlSKGDvaeaehtGERTGEEGErpteaEGENGEESGGEAeqeget 673
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31563526 294 -TVVLLK---------------KANFHRKASVIMVDELLSAYPHQLSFSEAGLRimITSHFPPKTRLSMASRMLINERQ- 356
Cdd:TIGR00927 674 eTKGENEsegeipaerkgeqegEGEIEAKEADHKGETEAEEVEHEGETEAEGTE--DEGEIETGEEGEEVEDEGEGEAEg 751
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31563526 357 RLINSRAYTNGESEVAIKIPIKHTVENGTGPSSAPDRG-VNGTRRDDVVAEAGNETENENEDNENDEEEEEDEDDDEGPY 435
Cdd:TIGR00927 752 KHEVETEGDRKETEHEGETEAEGKEDEDEGEIQAGEDGeMKGDEGAEGKVEHEGETEAGEKDEHEGQSETQADDTEVKDE 831
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31563526 436 T--------------------------------------------------------------PFDTPSGKLETVKWAFT 453
Cdd:TIGR00927 832 TgeqelnaenqgeakqdekgvdggggsdggdseeeeeeeeeeeeeeeeeeeeeeeeeeneeplSLEWPETRQKQAIYLFL 911
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31563526 454 WPLSFVLYFTVPNCNKPRWEKWFMVTFASSTLWIAAFSYMMVWMVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVA 533
Cdd:TIGR00927 912 LPIVFPLWLTVPDVRRQEARKFFVITFLGSIMWIAMFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVA 991
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31563526 534 RQGMGDMAVSNSIGSNVFDILIGLGLPWALQTLaVDYGSYIRLNSRGLIYSVGLLLASVFVTVFGVHLNKWQLDKKLGCG 613
Cdd:TIGR00927 992 RKGLGDMAVSSSVGSNIFDITVGLPVPWLLFSL-INGLQPVPVSSNGLFCAIVLLFLMLLFVISSIASCKWRMNKILGFT 1070
|
650
....*....|....*.
gi 31563526 614 CLLLYGVFLCFSIMTE 629
Cdd:TIGR00927 1071 MFLLYFVFLIISVMLE 1086
|
|
| TIGR00367 |
TIGR00367 |
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and ... |
112-605 |
4.63e-43 |
|
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General]
Pssm-ID: 273039 [Multi-domain] Cd Length: 307 Bit Score: 157.10 E-value: 4.63e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31563526 112 LHVLCAIYMFYALAIVCDDFFVPSLEKICERLHLSEDVAGATFMAAGSSAPELFTSVIGVFITKGDVGVGTIVGSAVFNI 191
Cdd:TIGR00367 1 LLLIGYLILGLILLIYGADLFVKSSVRIARHLGISPLIIGVTVVAIGTSLPELFTSLIASLMGQPDIGVGNVIGSNIFNI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31563526 192 LCIIGVCGLFAGQVVAlsSWCLLRDSIYYTLSVIALIVFIYDEKVSWWESLVLVLMYLIYivimkynacihqcferrtkg 271
Cdd:TIGR00367 81 LLILGLSAIFSPIIVD--KDWLRRDILFYLLVSILLLFFGLDGQISRIDGVVLLILYIVY-------------------- 138
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31563526 272 agnmvnglannaeiddssncdaTVVLLKKanfhrkasvimvdellsayphqlsfseaglrimitshfppktrlsmasrml 351
Cdd:TIGR00367 139 ----------------------LLFLVKN--------------------------------------------------- 145
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31563526 352 inerQRLINSRAYTngesevaikipikhtvengtgpssapdrgvngtrrddvvaeagnetenenednendeeeeededdd 431
Cdd:TIGR00367 146 ----ERWVKYDTYT------------------------------------------------------------------ 155
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31563526 432 egpytpfDTPSGKLETVKWAFTWPLSFVLYFTvpncnkprwekwfmvtfasstlWIAAFSYMMVWMVTIIGYTLGIPDVI 511
Cdd:TIGR00367 156 -------EENLDENNRRPQIFFSLVLLIIGLI----------------------GLVVGSRLLVDGAVKIAEILGISEKI 206
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31563526 512 MGITFLAAGTSVPDCMASLIVARQGMGDMAVSNSIGSNVFDILIGLGLPWALQTLAVDYGSYIRLNSRGLIYSVGLLLas 591
Cdd:TIGR00367 207 IGLTLLAIGTSLPELVVSLAAARKGLGDIAVGNVIGSNIFNILVGLGVPSLFMPIPVEPLAYNLDAPVMVIVTLLLML-- 284
|
490
....*....|....
gi 31563526 592 vfVTVFGVHLNKWQ 605
Cdd:TIGR00367 285 --FFKTSMKLGRWE 296
|
|
| ECM27 |
COG0530 |
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; |
130-624 |
5.12e-34 |
|
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
Pssm-ID: 440296 [Multi-domain] Cd Length: 293 Bit Score: 131.41 E-value: 5.12e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31563526 130 DFFVPSLEKICERLHLSEDVAGATFMAAGSSAPELFTSVIGVFITKGDVGVGTIVGSAVFNILCIIGVCGLFAGqvVALS 209
Cdd:COG0530 2 DLLVRGADALARRLGISPLVIGLTIVAFGTSLPELAVSVTAALDGSPDIAVGNVVGSNIANILLILGLAALIRP--LAVD 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31563526 210 SWCLLRDSIYYTLSVIALIVFIYDEKVSWWESLVLVLMYLIYIVimkynacihqcferrtkgagnmvnglannaeiddss 289
Cdd:COG0530 80 RRVLRRDLPFLLLASLLLLALLLDGTLSRIDGVILLLLYVLYLY------------------------------------ 123
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31563526 290 ncdatvvllkkanfhrkasvimvdellsayphqlsfseaglrimitshfppktrlsmasRMLINERQRlinsraytnges 369
Cdd:COG0530 124 -----------------------------------------------------------YLIRRARKE------------ 132
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31563526 370 evaikipikhtvengtgpssapdrgvngtRRDDVVAEagnetenenednendeeeeededddegpytpfDTPSGKLETVK 449
Cdd:COG0530 133 -----------------------------PAWEEVEE--------------------------------ELEEKPKMSLW 151
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31563526 450 WAFTWplsfvlyftvpncnkprwekwfmvtFASSTLWIAAFSYMMVWMVTIIGYTLGIPDVIMGITFLAAGTSVPDCMAS 529
Cdd:COG0530 152 KALLL-------------------------LVLGLALLVVGARLLVDGAVEIARALGVSELVIGLTIVAIGTSLPELATS 206
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31563526 530 LIVARQGMGDMAVSNSIGSNVFDILIGLGLPWALQTLAVDYGSYIRLnsrgliySVGLLLASVFVTVFGvhLNKWQLDKK 609
Cdd:COG0530 207 IVAARKGEDDLAVGNIIGSNIFNILLVLGIGALITPIPVDPAVLSFD-------LPVMLAATLLLLGLL--RTGGRIGRW 277
|
490
....*....|....*
gi 31563526 610 LGCGCLLLYGVFLCF 624
Cdd:COG0530 278 EGLLLLALYLAYLAL 292
|
|
| Na_Ca_ex |
pfam01699 |
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral ... |
113-255 |
9.82e-28 |
|
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.
Pssm-ID: 426387 [Multi-domain] Cd Length: 149 Bit Score: 108.84 E-value: 9.82e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31563526 113 HVLCAIYMFYALAIVCDDFFVPSLEKICERLHLSEDVAGATFMAAGSSAPELFTSVIGVFITKGDVGVGTIVGSAVFNIL 192
Cdd:pfam01699 1 LSLLLFILGLLLISVAADLLVDSAEVLARVLGISGTVLGLTILALGTSLPELVSSIIAALRGEPDLALGNVIGSNIFNIL 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 31563526 193 CIIGVCGLFAGQVVALS----SWCLLRDSIYYTLSVIALIVFIYDEKVSWWESLVLVLMYLIYIVIM 255
Cdd:pfam01699 81 LVLGLSALIGPVKVDSLllklDLGVLLLVALLLLLLLLLLLLPLFGRLSRFEGLVLLLLYIVYLVFQ 147
|
|
| Na_Ca_ex |
pfam01699 |
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral ... |
475-627 |
1.34e-26 |
|
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.
Pssm-ID: 426387 [Multi-domain] Cd Length: 149 Bit Score: 105.76 E-value: 1.34e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31563526 475 WFMVTFASSTLWIAAFSYMMVWMVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGMGDMAVSNSIGSNVFDIL 554
Cdd:pfam01699 1 LSLLLFILGLLLISVAADLLVDSAEVLARVLGISGTVLGLTILALGTSLPELVSSIIAALRGEPDLALGNVIGSNIFNIL 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 31563526 555 IGLGLPWALQTLAVDyGSYIRLNSRGLIYSVGLLLASVFVTVFgvhLNKWQLDKKLGCGCLLLYGVFLCFSIM 627
Cdd:pfam01699 81 LVLGLSALIGPVKVD-SLLLKLDLGVLLLVALLLLLLLLLLLL---PLFGRLSRFEGLVLLLLYIVYLVFQIV 149
|
|
| ECM27 |
COG0530 |
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; |
89-255 |
1.82e-23 |
|
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
Pssm-ID: 440296 [Multi-domain] Cd Length: 293 Bit Score: 100.98 E-value: 1.82e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31563526 89 EPALHEFPNDIFTNEDRRQGAVVLHVLCAIymfyALAIVCDDFFVPSLEKICERLHLSEDVAGATFMAAGSSAPELFTSV 168
Cdd:COG0530 132 EPAWEEVEEELEEKPKMSLWKALLLLVLGL----ALLVVGARLLVDGAVEIARALGVSELVIGLTIVAIGTSLPELATSI 207
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31563526 169 IGVFITKGDVGVGTIVGSAVFNILCIIGVCGLFAGqvVALSSWCLLRDSIYYTLSVIALIVFIY-DEKVSWWESLVLVLM 247
Cdd:COG0530 208 VAARKGEDDLAVGNIIGSNIFNILLVLGIGALITP--IPVDPAVLSFDLPVMLAATLLLLGLLRtGGRIGRWEGLLLLAL 285
|
....*...
gi 31563526 248 YLIYIVIM 255
Cdd:COG0530 286 YLAYLALL 293
|
|
| PLN03151 |
PLN03151 |
cation/calcium exchanger; Provisional |
108-638 |
1.39e-17 |
|
cation/calcium exchanger; Provisional
Pssm-ID: 215604 [Multi-domain] Cd Length: 650 Bit Score: 86.74 E-value: 1.39e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31563526 108 GAVVLHVlCAIYMFYALAIVCDDFFVPSLEKICERLHLSEDVAGATFMAAGSSAPELFTSvIGVFITK--GDVGVGTIVG 185
Cdd:PLN03151 139 GYAVLGV-WLVALFYLLGNTAADYFCCSLEKLSKLLRLPPTVAGVTLLPLGNGAPDVFAS-IAAFVGKdaGEVGLNSVLG 216
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31563526 186 SAVFNILCIIGVCGL-FAGQVVALSSWCLLRDSIYYTLSVIALIVFIYDEKVSWWESLVLVLMYLIYIVIMKYNAcIHQC 264
Cdd:PLN03151 217 GAVFVTCVVVGIVSLcVADKEVQIDKRCFIRDLCFFLFTLVSLLVILMVGKVTVGGAIAFVSIYVVYAFLVAANE-ILRK 295
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31563526 265 FERRTKgagnmvnglannaeiddssnCDATVVLLKKANFHRKASvimVDELLSAYPHQL-SFSEAGlrimitshfPPKTR 343
Cdd:PLN03151 296 HARRLK--------------------LDVVTPLLPVQGSIFSPS---VEEDESMYSPLLeSDTESD---------VPRLQ 343
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31563526 344 LSMASRMLinerqrlinsraytngESEVAIKipIKHTVENGTGPSSAPDRGVNgtrrdDVVAEAGNETENENEDNENDEE 423
Cdd:PLN03151 344 TSLPQWMW----------------ASNVAIY--SNHFAKGSVHDEERPPWGWT-----DEGAEVESSLFSCSKLFSLLEM 400
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31563526 424 EEEDEDDDEGPYT-------PFDTPSGKLETVKWAFTW-----------------------PLSFVLY-FTVPNcNKPR- 471
Cdd:PLN03151 401 PLTIPRRLTIPIVeedrwskTYAVASASLAPVLLAFLWssqddvslqariaayfigvaigsTLGFLAYkYTEPD-RPPRr 479
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31563526 472 -WEKWFMVTFASSTLWIAAFSYMMVWMVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGmGD---MAVSNSIG 547
Cdd:PLN03151 480 fLIPWVLGGFIMSIVWFYMIANELVALLVAFGVIFGINPSILGLTVLAWGNSMGDLMSNVALAMNG-GDgvqIAMSGCYA 558
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31563526 548 SNVFDILIGLGLPWALQTLAVDYGSYIRLNSRGLIYSVGLLLASVFVTVFGVHLNKWQLDKKLGCGCLLLYGVFLCFSIM 627
Cdd:PLN03151 559 GPMFNTLVGLGMSMLLGAWSKSPESYMLPEDSSLFYTMGFLVSGLIWALVVLPRNDMRPNKTLGVGLIALYLIFLTFRVS 638
|
570
....*....|.
gi 31563526 628 TEFNVFTFVNL 638
Cdd:PLN03151 639 TAMGFIPWAGL 649
|
|
| caca |
TIGR00845 |
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ... |
104-315 |
4.14e-15 |
|
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]
Pssm-ID: 273296 [Multi-domain] Cd Length: 928 Bit Score: 79.07 E-value: 4.14e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31563526 104 DRRQGAVVLHVLcAIYMFYALAIVCDDFFV----------------PSLEKICERLHL-SEDVAGATFMAAGSSAPELFT 166
Cdd:TIGR00845 70 DKIARATVYFVA-MVYMFLGVSIIADRFMAsievitsqekeitikkPNGETTVTTVRIwNETVSNLTLMALGSSAPEILL 148
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31563526 167 SVIGVF---ITKGDVGVGTIVGSAVFNILCIIGVCGLF--AGQVVAL---------SSWcllrdSIY-YTLSVIALIVFI 231
Cdd:TIGR00845 149 SVIEVCghnFEAGDLGPSTIVGSAAFNMFIIIAICVYVipDGETRKIkhlrvffvtAAW-----SVFaYVWLYLILAVFS 223
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31563526 232 YDEkVSWWESLvLVLMYLIYIVIMKYNACIHQCFE-------RRTKGAGNMVNGLANNAEIDDSSNCDATVVLLKKANFH 304
Cdd:TIGR00845 224 PGV-VEVWEGL-LTFFFFPLCVVFAWVADRRLLFYkyvykryRAGKQRGMIIETEGDRPKSKTEIEMDGKMVNSHVDNFL 301
|
250
....*....|.
gi 31563526 305 RKASVIMVDEL 315
Cdd:TIGR00845 302 DGALVLEVKEF 312
|
|
| TIGR00367 |
TIGR00367 |
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and ... |
103-251 |
1.88e-13 |
|
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General]
Pssm-ID: 273039 [Multi-domain] Cd Length: 307 Bit Score: 71.59 E-value: 1.88e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31563526 103 EDRRQGAVVLHVLCAIYMFYALAIVCDdFFVPSLEKICERLHLSEDVAGATFMAAGSSAPELFTSVIGVFITKGDVGVGT 182
Cdd:TIGR00367 161 ENNRRPQIFFSLVLLIIGLIGLVVGSR-LLVDGAVKIAEILGISEKIIGLTLLAIGTSLPELVVSLAAARKGLGDIAVGN 239
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 31563526 183 IVGSAVFNILCIIGVCGLFA-GQVVALSswcLLRD-SIYYTLSVIALIVFIYDEKVSWWESLVLVLMYLIY 251
Cdd:TIGR00367 240 VIGSNIFNILVGLGVPSLFMpIPVEPLA---YNLDaPVMVIVTLLLMLFFKTSMKLGRWEGILLLALYIAY 307
|
|
| ECM27 |
COG0530 |
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; |
505-629 |
2.10e-13 |
|
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
Pssm-ID: 440296 [Multi-domain] Cd Length: 293 Bit Score: 71.32 E-value: 2.10e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31563526 505 LGIPDVIMGITFLAAGTSVPDCMASLIVARQGMGDMAVSNSIGSNVFDILIGLGLPWALQTLAVDygsyirlnSRGLIYS 584
Cdd:COG0530 15 LGISPLVIGLTIVAFGTSLPELAVSVTAALDGSPDIAVGNVVGSNIANILLILGLAALIRPLAVD--------RRVLRRD 86
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 31563526 585 VGLLLASVFVTVFGVHLNkwQLDKKLGCGCLLLYGVFLCFSIMTE 629
Cdd:COG0530 87 LPFLLLASLLLLALLLDG--TLSRIDGVILLLLYVLYLYYLIRRA 129
|
|
| PRK10734 |
PRK10734 |
putative calcium/sodium:proton antiporter; Provisional |
493-635 |
2.20e-13 |
|
putative calcium/sodium:proton antiporter; Provisional
Pssm-ID: 182684 [Multi-domain] Cd Length: 325 Bit Score: 71.60 E-value: 2.20e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31563526 493 MMVWMVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGMGDMAVSNSIGSNVFDILIGLGLPWALQTLAVDYGS 572
Cdd:PRK10734 192 MVIDNATVLANYFAISELTIGLTVIAIGTSLPELATAIAGARKGENDIAVGNIIGSNIFNIVIVLGLPALISPGEINPLA 271
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 31563526 573 YIRlnsrglIYSVgLLLASVFVTVFGvhlnkWQLDKKLG--CGCLLLYGVFLCFSIMTEFNVFTF 635
Cdd:PRK10734 272 FSR------DYWV-MLLVSVIFALLC-----WRRKRRIGrgAGALLLGGFIVWLAMLYWLSPILV 324
|
|
| TIGR00367 |
TIGR00367 |
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and ... |
499-626 |
8.59e-12 |
|
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General]
Pssm-ID: 273039 [Multi-domain] Cd Length: 307 Bit Score: 66.58 E-value: 8.59e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31563526 499 TIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGMGDMAVSNSIGSNVFDILIGLGLPWALQTLAVDYgSYIRLNS 578
Cdd:TIGR00367 26 VRIARHLGISPLIIGVTVVAIGTSLPELFTSLIASLMGQPDIGVGNVIGSNIFNILLILGLSAIFSPIIVDK-DWLRRDI 104
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 31563526 579 RGLIYSVGLLLasvFVTVFGvhlnkwQLDKKLGCGCLLLYGVFLCFSI 626
Cdd:TIGR00367 105 LFYLLVSILLL---FFGLDG------QISRIDGVVLLILYIVYLLFLV 143
|
|
| caca |
TIGR00845 |
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ... |
459-596 |
1.52e-10 |
|
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]
Pssm-ID: 273296 [Multi-domain] Cd Length: 928 Bit Score: 64.43 E-value: 1.52e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31563526 459 VLYFTVPNCNkpRWEKWfmVTFASSTLWIAAFSYMMVWMVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGMG 538
Cdd:TIGR00845 742 VLFAFVPPTE--YWGGW--ACFVVSILMIGVLTAFIGDLASHFGCTIGLKDSVTAVVFVALGTSVPDTFASKVAATQDQY 817
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 31563526 539 -DMAVSNSIGSNVFDILIGLGLPWalqTLAVDY----GSYIRLNSRGLIYSVGLLLASVFVTV 596
Cdd:TIGR00845 818 aDASIGNVTGSNAVNVFLGIGVAW---SIAAIYhaanGTQFKVSPGTLAFSVTLFTIFAFICI 877
|
|
| PRK10734 |
PRK10734 |
putative calcium/sodium:proton antiporter; Provisional |
494-626 |
1.95e-10 |
|
putative calcium/sodium:proton antiporter; Provisional
Pssm-ID: 182684 [Multi-domain] Cd Length: 325 Bit Score: 62.74 E-value: 1.95e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31563526 494 MVWMVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGMGDMAVSNSIGSNVFDILIGLGLPWALQTLAVdYGSY 573
Cdd:PRK10734 22 LVFAASILCRTFGIPPLIIGMTVVGIGTSLPEIIVSVAASLHGQRDLAVGTALGSNITNILLILGLAALIRPFTV-HSDV 100
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 31563526 574 IRLNsrgliysvglLLASVFVTVF-GVHLNKWQLDKKLGCGCLLLYGVFLCFSI 626
Cdd:PRK10734 101 LRRE----------LPLMLLVSVLaGSVLYDGQLSRSDGIFLLLLAVLWLLFIV 144
|
|
| PRK10734 |
PRK10734 |
putative calcium/sodium:proton antiporter; Provisional |
111-255 |
5.29e-07 |
|
putative calcium/sodium:proton antiporter; Provisional
Pssm-ID: 182684 [Multi-domain] Cd Length: 325 Bit Score: 51.96 E-value: 5.29e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31563526 111 VLHVLCAIYMFYALAIVCDDFFVPSLekicerlhlsedVAGATFMAAGSSAPELFTSVIGVFITKGDVGVGTIVGSAVFN 190
Cdd:PRK10734 13 LLLVYGADRLVFAASILCRTFGIPPL------------IIGMTVVGIGTSLPEIIVSVAASLHGQRDLAVGTALGSNITN 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 31563526 191 ILCIIGVCGLFAGQVVALSswcLLRDSIYYTLSVIALI-VFIYDEKVSWWESLVLVLMYLIYIVIM 255
Cdd:PRK10734 81 ILLILGLAALIRPFTVHSD---VLRRELPLMLLVSVLAgSVLYDGQLSRSDGIFLLLLAVLWLLFI 143
|
|
| PRK10734 |
PRK10734 |
putative calcium/sodium:proton antiporter; Provisional |
145-222 |
5.89e-07 |
|
putative calcium/sodium:proton antiporter; Provisional
Pssm-ID: 182684 [Multi-domain] Cd Length: 325 Bit Score: 51.96 E-value: 5.89e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31563526 145 LSEDVAGATFMAAGSSAPELFTSVIGVFITKGDVGVGTIVGSAVFNILCIIGVCGL-----FAGQVVALSSWCLLRDSIY 219
Cdd:PRK10734 206 ISELTIGLTVIAIGTSLPELATAIAGARKGENDIAVGNIIGSNIFNIVIVLGLPALispgeINPLAFSRDYWVMLLVSVI 285
|
...
gi 31563526 220 YTL 222
Cdd:PRK10734 286 FAL 288
|
|
| caca2 |
TIGR00846 |
calcium/proton exchanger; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the ... |
126-251 |
1.64e-03 |
|
calcium/proton exchanger; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is generated from the calcium ion/proton exchangers of the CacA family. [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273297 [Multi-domain] Cd Length: 363 Bit Score: 41.29 E-value: 1.64e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31563526 126 IVCDDFFVPSLEKICERLHLSEDVAGATFMAAGSSAPELFTSVIGVFITKGDVGVGTIVGSAVFNILCIIgvcglfagQV 205
Cdd:TIGR00846 232 ILLADYLVDTIDDAVDSWGLSVAFIGLILAPIVGNAAEHVTAVKAALKNKLDLALGVALGSALQIILFVV--------PL 303
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 31563526 206 VALSSWCLLRD---------SIYYTLSVIALIVFIYDEKVSWWESLVLVLMYLIY 251
Cdd:TIGR00846 304 VVLVAWMLGIPmdlnfgtfeTIVLALSLFLTTITLQDGRSNYLEGAVLLALYIII 358
|
|
| |
