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Conserved domains on  [gi|146134355|ref|NP_065614|]
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zinc finger protein 467 isoform a [Mus musculus]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
190-564 1.51e-12

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 70.11  E-value: 1.51e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146134355 190 CPDCGRSFTQRAHMLLHQRSHRGERPFPCS--ECDKRFSKKAHLTRHLRTHTGERPY-PCAECGKRFSQKIHLGSHQKTH 266
Cdd:COG5048   36 CPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDlNSKSLPLSNSKASSSSLSSSSS 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146134355 267 TGERPFPCTECEKRFRKKTHLIRHQRIHTGERPYQCTQCTRSF------THKQHLVRHQRVHDAASRTRSSPDIPVAPHS 340
Cdd:COG5048  116 NSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSvntpqsNSLHPPLPANSLSKDPSSNLSLLISSNVSTS 195

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146134355 341 PTASLTPSPPGPKPFAcSHCGQSFGwKKNLATHQSLHLTEGRPFGCDECALGTNVDPAAEPSACTPHAPDCGPGSGP--A 418
Cdd:COG5048  196 IPSSSENSPLSSSYSI-PSSSSDQN-LENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSqsS 273

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146134355 419 APQRTTSSERSFF-----CPDCGRGFAHGQHLARHRR--VHTGE--RPFAC--AQCGRRFGSRPNLVAHSRAHSGARPFA 487
Cdd:COG5048  274 SPNESDSSSEKGFslpikSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAK 353

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146134355 488 C--AQCGRRFSRKSHLGRHQAVH-----TGSRPHACAV--CARCFSSKTNLVRHQAIHTGSRP--FSCPQCAKSFSRKTH 556
Cdd:COG5048  354 EklLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYN 433


                 ....*...
gi 146134355 557 LVRHQRIH 564
Cdd:COG5048  434 LIPHKKIH 441
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
190-564 1.51e-12

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 70.11  E-value: 1.51e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146134355 190 CPDCGRSFTQRAHMLLHQRSHRGERPFPCS--ECDKRFSKKAHLTRHLRTHTGERPY-PCAECGKRFSQKIHLGSHQKTH 266
Cdd:COG5048   36 CPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDlNSKSLPLSNSKASSSSLSSSSS 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146134355 267 TGERPFPCTECEKRFRKKTHLIRHQRIHTGERPYQCTQCTRSF------THKQHLVRHQRVHDAASRTRSSPDIPVAPHS 340
Cdd:COG5048  116 NSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSvntpqsNSLHPPLPANSLSKDPSSNLSLLISSNVSTS 195

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146134355 341 PTASLTPSPPGPKPFAcSHCGQSFGwKKNLATHQSLHLTEGRPFGCDECALGTNVDPAAEPSACTPHAPDCGPGSGP--A 418
Cdd:COG5048  196 IPSSSENSPLSSSYSI-PSSSSDQN-LENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSqsS 273

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146134355 419 APQRTTSSERSFF-----CPDCGRGFAHGQHLARHRR--VHTGE--RPFAC--AQCGRRFGSRPNLVAHSRAHSGARPFA 487
Cdd:COG5048  274 SPNESDSSSEKGFslpikSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAK 353

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146134355 488 C--AQCGRRFSRKSHLGRHQAVH-----TGSRPHACAV--CARCFSSKTNLVRHQAIHTGSRP--FSCPQCAKSFSRKTH 556
Cdd:COG5048  354 EklLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYN 433


                 ....*...
gi 146134355 557 LVRHQRIH 564
Cdd:COG5048  434 LIPHKKIH 441
zf-H2C2_2 pfam13465
Zinc-finger double domain;
230-255 2.01e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.59  E-value: 2.01e-05
                          10        20
                  ....*....|....*....|....*.
gi 146134355  230 HLTRHLRTHTGERPYPCAECGKRFSQ 255
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
190-564 1.51e-12

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 70.11  E-value: 1.51e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146134355 190 CPDCGRSFTQRAHMLLHQRSHRGERPFPCS--ECDKRFSKKAHLTRHLRTHTGERPY-PCAECGKRFSQKIHLGSHQKTH 266
Cdd:COG5048   36 CPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDlNSKSLPLSNSKASSSSLSSSSS 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146134355 267 TGERPFPCTECEKRFRKKTHLIRHQRIHTGERPYQCTQCTRSF------THKQHLVRHQRVHDAASRTRSSPDIPVAPHS 340
Cdd:COG5048  116 NSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSvntpqsNSLHPPLPANSLSKDPSSNLSLLISSNVSTS 195

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146134355 341 PTASLTPSPPGPKPFAcSHCGQSFGwKKNLATHQSLHLTEGRPFGCDECALGTNVDPAAEPSACTPHAPDCGPGSGP--A 418
Cdd:COG5048  196 IPSSSENSPLSSSYSI-PSSSSDQN-LENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSqsS 273

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146134355 419 APQRTTSSERSFF-----CPDCGRGFAHGQHLARHRR--VHTGE--RPFAC--AQCGRRFGSRPNLVAHSRAHSGARPFA 487
Cdd:COG5048  274 SPNESDSSSEKGFslpikSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAK 353

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146134355 488 C--AQCGRRFSRKSHLGRHQAVH-----TGSRPHACAV--CARCFSSKTNLVRHQAIHTGSRP--FSCPQCAKSFSRKTH 556
Cdd:COG5048  354 EklLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYN 433


                 ....*...
gi 146134355 557 LVRHQRIH 564
Cdd:COG5048  434 LIPHKKIH 441
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
270-591 1.15e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 57.78  E-value: 1.15e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146134355 270 RPFPCTECEKRFRKKTHLIRHQRIHTGERPYQCTQCT----RSFTHKQHlvRHQRVHDAASRTRSSPDIPVAPHSPTASL 345
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGcdksFSRPLELS--RHLRTHHNNPSDLNSKSLPLSNSKASSSS 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146134355 346 TPSPP--GPKPFACSHCGQSFGWKKNLA--THQSLHLTEGRPFGCDECALGTNVDPAAEPSACTPHAPDCGPGSGPAAPQ 421
Cdd:COG5048  110 LSSSSsnSNDNNLLSSHSLPPSSRDPQLpdLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLLIS 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146134355 422 -RTTSSERSFFCPDCGRGFAHGQHLARHRRVHTGERPFACAQCGRRFGSRPNLVAHSRAHSGARPFACAQCGR------R 494
Cdd:COG5048  190 sNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRsslptaS 269

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146134355 495 FSRKSHLGRHQAVHTG-SRPHACAVCARCFSSKTNLVRHQ--AIHTGS--RPFSCP--QCAKSFSRKTHLVRHQRIHGDa 567
Cdd:COG5048  270 SQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPysLCGKLFSRNDALKRHILLHTS- 348

                        330       340
                 ....*....|....*....|....
gi 146134355 568 ALPAPASNLSAPAWSNPSEVVPPP 591
Cdd:COG5048  349 ISPAKEKLLNSSSKFSPLLNNEPP 372
zf-H2C2_2 pfam13465
Zinc-finger double domain;
230-255 2.01e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.59  E-value: 2.01e-05
                          10        20
                  ....*....|....*....|....*.
gi 146134355  230 HLTRHLRTHTGERPYPCAECGKRFSQ 255
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
286-311 1.23e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.23e-04
                          10        20
                  ....*....|....*....|....*.
gi 146134355  286 HLIRHQRIHTGERPYQCTQCTRSFTH 311
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
528-553 6.23e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 6.23e-04
                          10        20
                  ....*....|....*....|....*.
gi 146134355  528 NLVRHQAIHTGSRPFSCPQCAKSFSR 553
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 216-238 7.56e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.89  E-value: 7.56e-04
                          10        20
                  ....*....|....*....|...
gi 146134355  216 FPCSECDKRFSKKAHLTRHLRTH 238
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
261-281 2.88e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.88e-03
                          10        20
                  ....*....|....*....|.
gi 146134355  261 SHQKTHTGERPFPCTECEKRF 281
Cdd:pfam13465   4 RHMRTHTGEKPYKCPECGKSF 24
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 300-322 3.36e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.35  E-value: 3.36e-03
                          10        20
                  ....*....|....*....|...
gi 146134355  300 YQCTQCTRSFTHKQHLVRHQRVH 322
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
202-227 3.37e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.37e-03
                          10        20
                  ....*....|....*....|....*.
gi 146134355  202 HMLLHQRSHRGERPFPCSECDKRFSK 227
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 272-294 3.63e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.97  E-value: 3.63e-03
                          10        20
                  ....*....|....*....|...
gi 146134355  272 FPCTECEKRFRKKTHLIRHQRIH 294
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 542-564 4.05e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.97  E-value: 4.05e-03
                          10        20
                  ....*....|....*....|...
gi 146134355  542 FSCPQCAKSFSRKTHLVRHQRIH 564
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
187-318 4.19e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.06  E-value: 4.19e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146134355 187 PCACPDCGRSFTQRAHMLLHQRS--HRGE--RPFPCSE--CDKRFSKKAHLTRHLRTHTGERPYPC-------------- 246
Cdd:COG5048  289 PIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEkllnssskfsplln 368

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 146134355 247 -----------------------AECGKRFSQKIHLGSHQKTHTGERP--FPCTECEKRFRKKTHLIRHQRIHTGERPYQ 301
Cdd:COG5048  369 neppqslqqykdlkndkksetlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLL 448

                        170
                 ....*....|....*..
gi 146134355 302 CtQCTRSFTHKQHLVRH 318
Cdd:COG5048  449 C-SILKSFRRDLDLSNH 464
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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