NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1834395647|ref|NP_065574|]
View 

choline O-acetyltransferase isoform 2 [Homo sapiens]

Protein Classification

choline/carnitine O-acyltransferase( domain architecture ID 10466051)

choline/carnitine O-acyltransferase catalyzes the reversible transfer of acyl moieties from acyl-CoA to carnitine or choline

CATH:  3.30.559.70
EC:  2.3.1.-
Gene Ontology:  GO:0016746
PubMed:  29730527
SCOP:  4003020

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
Carn_acyltransf pfam00755
Choline/Carnitine o-acyltransferase;
134-713 0e+00

Choline/Carnitine o-acyltransferase;


:

Pssm-ID: 459926  Cd Length: 570  Bit Score: 721.28  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1834395647 134 LPVPPLQQTLATYLQCMRHLVSEEQFRKSQAIVQQFGAPGGlgETLQQKLLERQEKTANWVSEYWLNDMYLNNRLALPVN 213
Cdd:pfam00755   1 LPVPPLEDTLDRYLESVKPLLTEEEYERTEKLVEEFLKGGG--PKLQERLLERAKDKKNWLEDWWLDYAYLEYRDPLVLN 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1834395647 214 SSPAVIFAR---QHFPGTDDQLRFAASLISGVLSYKALLDSHSIPTDcakgQLSGQPLCMKQYYGLFSSYRLPGHTQDTL 290
Cdd:pfam00755  79 SNPFFVFPDdpdPLDEPTNTQLKRAANLIYAALKFKRLLDRETLPPD----VEGGVPLCMSQYKRLFNTTRIPGKERDIL 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1834395647 291 VAQNSSImPEPEHVIVACCNQFFVLDVVINFRRLSEGDLFTQLRKIVKMASNEDERLPPIGLLTSDGRSEWAEARTVLVK 370
Cdd:pfam00755 155 QHFPDSG-VEPRHIVVLRKGQFYKVDVLDSGRPLSPAELEAQLQRILDDASASNPPPPPVGVLTTDNRDVWAKAREELLK 233
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1834395647 371 -DSTNRDSLDMIERCICLVCLDapgGVELSDTHRALQLLHGGGYSKNGANRWYDKSLQFVVGRDGTCGVVCEHSPFDGIV 449
Cdd:pfam00755 234 lDPGNAESLEAIESALFVVCLD---DASPEDKTELEGSHGGGSLGGDGTNRWFDKSLQLIVFKNGRAGFNGEHSPADGTP 310
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1834395647 450 LVQCTEHLLKHVtQSSRKLIRADSVSELPAPRRLRWKCSPEIQGHLASSAEKLQRIVKNLDFIVYKFDNYGKTFIKKQKC 529
Cdd:pfam00755 311 VLRLNDYVLKSI-FENKPVSSSSASSLPPPPEKLEFELDPELKSAIEEAETRFDKLISDLDLRVLEFTDYGKNFIKKFKL 389
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1834395647 530 SPDAFIQVALQLAFYRLHRRLVPTYESASIRRFQEGRVDNIRSATPEALAFVRAVTDHKAavPASEKLLLLKDAIRAQTA 609
Cdd:pfam00755 390 SPDAFIQMALQLAYYRLHGKFAPTYESASTRKFRHGRTETIRSVTPESVAFVKAMLDPSA--SDEEKRELLRAAVKAHVK 467
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1834395647 610 YTVMAITGMAIDNHLLALRELARAMcKELPEMFMDETYLMSNRFVLSTSQVPTTTEMFCCYGPVVPNGYGACYNPQPETI 689
Cdd:pfam00755 468 LTKEASTGQGVDRHLFGLKLVAKEG-GLLPPLFSDPAYKKSNHWVLSTSQLGSPALRGGGFGPVVPDGYGIGYNIQDDSI 546
                         570       580
                  ....*....|....*....|....
gi 1834395647 690 LFCISSFHSCKETSSSKFAKAVEE 713
Cdd:pfam00755 547 SFSISSFKSSPETDTERFAKALEE 570
PHA03247 super family cl33720
large tegument protein UL36; Provisional
27-138 2.51e-04

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.93  E-value: 2.51e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1834395647   27 GRREVRPACFLQSG-GRGDPGDVGGPAGNPGCSPHPRAATRPPPLPAHTPAHTPEWCGAASAEAAEPRRAGPHlciPAPG 105
Cdd:PHA03247  2583 TSRARRPDAPPQSArPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDD---PAPG 2659
                           90       100       110
                   ....*....|....*....|....*....|...
gi 1834395647  106 LTktpileKVPRKMAAKTPSSEESGLPKLPVPP 138
Cdd:PHA03247  2660 RV------SRPRRARRLGRAAQASSPPQRPRRR 2686
 
Name Accession Description Interval E-value
Carn_acyltransf pfam00755
Choline/Carnitine o-acyltransferase;
134-713 0e+00

Choline/Carnitine o-acyltransferase;


Pssm-ID: 459926  Cd Length: 570  Bit Score: 721.28  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1834395647 134 LPVPPLQQTLATYLQCMRHLVSEEQFRKSQAIVQQFGAPGGlgETLQQKLLERQEKTANWVSEYWLNDMYLNNRLALPVN 213
Cdd:pfam00755   1 LPVPPLEDTLDRYLESVKPLLTEEEYERTEKLVEEFLKGGG--PKLQERLLERAKDKKNWLEDWWLDYAYLEYRDPLVLN 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1834395647 214 SSPAVIFAR---QHFPGTDDQLRFAASLISGVLSYKALLDSHSIPTDcakgQLSGQPLCMKQYYGLFSSYRLPGHTQDTL 290
Cdd:pfam00755  79 SNPFFVFPDdpdPLDEPTNTQLKRAANLIYAALKFKRLLDRETLPPD----VEGGVPLCMSQYKRLFNTTRIPGKERDIL 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1834395647 291 VAQNSSImPEPEHVIVACCNQFFVLDVVINFRRLSEGDLFTQLRKIVKMASNEDERLPPIGLLTSDGRSEWAEARTVLVK 370
Cdd:pfam00755 155 QHFPDSG-VEPRHIVVLRKGQFYKVDVLDSGRPLSPAELEAQLQRILDDASASNPPPPPVGVLTTDNRDVWAKAREELLK 233
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1834395647 371 -DSTNRDSLDMIERCICLVCLDapgGVELSDTHRALQLLHGGGYSKNGANRWYDKSLQFVVGRDGTCGVVCEHSPFDGIV 449
Cdd:pfam00755 234 lDPGNAESLEAIESALFVVCLD---DASPEDKTELEGSHGGGSLGGDGTNRWFDKSLQLIVFKNGRAGFNGEHSPADGTP 310
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1834395647 450 LVQCTEHLLKHVtQSSRKLIRADSVSELPAPRRLRWKCSPEIQGHLASSAEKLQRIVKNLDFIVYKFDNYGKTFIKKQKC 529
Cdd:pfam00755 311 VLRLNDYVLKSI-FENKPVSSSSASSLPPPPEKLEFELDPELKSAIEEAETRFDKLISDLDLRVLEFTDYGKNFIKKFKL 389
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1834395647 530 SPDAFIQVALQLAFYRLHRRLVPTYESASIRRFQEGRVDNIRSATPEALAFVRAVTDHKAavPASEKLLLLKDAIRAQTA 609
Cdd:pfam00755 390 SPDAFIQMALQLAYYRLHGKFAPTYESASTRKFRHGRTETIRSVTPESVAFVKAMLDPSA--SDEEKRELLRAAVKAHVK 467
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1834395647 610 YTVMAITGMAIDNHLLALRELARAMcKELPEMFMDETYLMSNRFVLSTSQVPTTTEMFCCYGPVVPNGYGACYNPQPETI 689
Cdd:pfam00755 468 LTKEASTGQGVDRHLFGLKLVAKEG-GLLPPLFSDPAYKKSNHWVLSTSQLGSPALRGGGFGPVVPDGYGIGYNIQDDSI 546
                         570       580
                  ....*....|....*....|....
gi 1834395647 690 LFCISSFHSCKETSSSKFAKAVEE 713
Cdd:pfam00755 547 SFSISSFKSSPETDTERFAKALEE 570
PHA03247 PHA03247
large tegument protein UL36; Provisional
27-138 2.51e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.93  E-value: 2.51e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1834395647   27 GRREVRPACFLQSG-GRGDPGDVGGPAGNPGCSPHPRAATRPPPLPAHTPAHTPEWCGAASAEAAEPRRAGPHlciPAPG 105
Cdd:PHA03247  2583 TSRARRPDAPPQSArPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDD---PAPG 2659
                           90       100       110
                   ....*....|....*....|....*....|...
gi 1834395647  106 LTktpileKVPRKMAAKTPSSEESGLPKLPVPP 138
Cdd:PHA03247  2660 RV------SRPRRARRLGRAAQASSPPQRPRRR 2686
TALPID3 pfam15324
Hedgehog signalling target; TALPID3 is a family of eukaryotic proteins that are targets for ...
45-137 6.61e-04

Hedgehog signalling target; TALPID3 is a family of eukaryotic proteins that are targets for Hedgehog signalling. Mutations in this gene noticed first in chickens lead to multiple abnormalities of development.


Pssm-ID: 434634 [Multi-domain]  Cd Length: 1288  Bit Score: 43.34  E-value: 6.61e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1834395647   45 PGDVGGPAGNPGCSPhpraatrPPPLPAHTPAHTPEWCGAASAEAAEPRR----AGPHLCIPAPGLTKTPILEKV--PRK 118
Cdd:pfam15324  985 PTPVPTPQPTPPCSP-------PSPLKEPSPVKTPDSSPCVSEHDFFPVKeippEKGADTGPAVSLVITPTVTPIatPPP 1057
                           90
                   ....*....|....*....
gi 1834395647  119 MAAKTPSSEESGLPKLPVP 137
Cdd:pfam15324 1058 AATPTPPLSENSIDKLKSP 1076
 
Name Accession Description Interval E-value
Carn_acyltransf pfam00755
Choline/Carnitine o-acyltransferase;
134-713 0e+00

Choline/Carnitine o-acyltransferase;


Pssm-ID: 459926  Cd Length: 570  Bit Score: 721.28  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1834395647 134 LPVPPLQQTLATYLQCMRHLVSEEQFRKSQAIVQQFGAPGGlgETLQQKLLERQEKTANWVSEYWLNDMYLNNRLALPVN 213
Cdd:pfam00755   1 LPVPPLEDTLDRYLESVKPLLTEEEYERTEKLVEEFLKGGG--PKLQERLLERAKDKKNWLEDWWLDYAYLEYRDPLVLN 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1834395647 214 SSPAVIFAR---QHFPGTDDQLRFAASLISGVLSYKALLDSHSIPTDcakgQLSGQPLCMKQYYGLFSSYRLPGHTQDTL 290
Cdd:pfam00755  79 SNPFFVFPDdpdPLDEPTNTQLKRAANLIYAALKFKRLLDRETLPPD----VEGGVPLCMSQYKRLFNTTRIPGKERDIL 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1834395647 291 VAQNSSImPEPEHVIVACCNQFFVLDVVINFRRLSEGDLFTQLRKIVKMASNEDERLPPIGLLTSDGRSEWAEARTVLVK 370
Cdd:pfam00755 155 QHFPDSG-VEPRHIVVLRKGQFYKVDVLDSGRPLSPAELEAQLQRILDDASASNPPPPPVGVLTTDNRDVWAKAREELLK 233
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1834395647 371 -DSTNRDSLDMIERCICLVCLDapgGVELSDTHRALQLLHGGGYSKNGANRWYDKSLQFVVGRDGTCGVVCEHSPFDGIV 449
Cdd:pfam00755 234 lDPGNAESLEAIESALFVVCLD---DASPEDKTELEGSHGGGSLGGDGTNRWFDKSLQLIVFKNGRAGFNGEHSPADGTP 310
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1834395647 450 LVQCTEHLLKHVtQSSRKLIRADSVSELPAPRRLRWKCSPEIQGHLASSAEKLQRIVKNLDFIVYKFDNYGKTFIKKQKC 529
Cdd:pfam00755 311 VLRLNDYVLKSI-FENKPVSSSSASSLPPPPEKLEFELDPELKSAIEEAETRFDKLISDLDLRVLEFTDYGKNFIKKFKL 389
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1834395647 530 SPDAFIQVALQLAFYRLHRRLVPTYESASIRRFQEGRVDNIRSATPEALAFVRAVTDHKAavPASEKLLLLKDAIRAQTA 609
Cdd:pfam00755 390 SPDAFIQMALQLAYYRLHGKFAPTYESASTRKFRHGRTETIRSVTPESVAFVKAMLDPSA--SDEEKRELLRAAVKAHVK 467
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1834395647 610 YTVMAITGMAIDNHLLALRELARAMcKELPEMFMDETYLMSNRFVLSTSQVPTTTEMFCCYGPVVPNGYGACYNPQPETI 689
Cdd:pfam00755 468 LTKEASTGQGVDRHLFGLKLVAKEG-GLLPPLFSDPAYKKSNHWVLSTSQLGSPALRGGGFGPVVPDGYGIGYNIQDDSI 546
                         570       580
                  ....*....|....*....|....
gi 1834395647 690 LFCISSFHSCKETSSSKFAKAVEE 713
Cdd:pfam00755 547 SFSISSFKSSPETDTERFAKALEE 570
PHA03247 PHA03247
large tegument protein UL36; Provisional
27-138 2.51e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.93  E-value: 2.51e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1834395647   27 GRREVRPACFLQSG-GRGDPGDVGGPAGNPGCSPHPRAATRPPPLPAHTPAHTPEWCGAASAEAAEPRRAGPHlciPAPG 105
Cdd:PHA03247  2583 TSRARRPDAPPQSArPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDD---PAPG 2659
                           90       100       110
                   ....*....|....*....|....*....|...
gi 1834395647  106 LTktpileKVPRKMAAKTPSSEESGLPKLPVPP 138
Cdd:PHA03247  2660 RV------SRPRRARRLGRAAQASSPPQRPRRR 2686
PHA03378 PHA03378
EBNA-3B; Provisional
43-141 4.71e-04

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 43.90  E-value: 4.71e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1834395647  43 GDPGDVGGPAGNPGCSPHPRAA---TRPP---PLPAHTPAHTPewcGAASAEAAEPRRAGPHLCIP-APGLTKTPILEKV 115
Cdd:PHA03378  709 APPGRAQRPAAATGRARPPAAApgrARPPaaaPGRARPPAAAP---GRARPPAAAPGRARPPAAAPgAPTPQPPPQAPPA 785
                          90       100       110
                  ....*....|....*....|....*....|...
gi 1834395647 116 PRK--MAAKTPSSEESGLPK-----LPVPPLQQ 141
Cdd:PHA03378  786 PQQrpRGAPTPQPPPQAGPTsmqlmPRAAPGQQ 818
TALPID3 pfam15324
Hedgehog signalling target; TALPID3 is a family of eukaryotic proteins that are targets for ...
45-137 6.61e-04

Hedgehog signalling target; TALPID3 is a family of eukaryotic proteins that are targets for Hedgehog signalling. Mutations in this gene noticed first in chickens lead to multiple abnormalities of development.


Pssm-ID: 434634 [Multi-domain]  Cd Length: 1288  Bit Score: 43.34  E-value: 6.61e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1834395647   45 PGDVGGPAGNPGCSPhpraatrPPPLPAHTPAHTPEWCGAASAEAAEPRR----AGPHLCIPAPGLTKTPILEKV--PRK 118
Cdd:pfam15324  985 PTPVPTPQPTPPCSP-------PSPLKEPSPVKTPDSSPCVSEHDFFPVKeippEKGADTGPAVSLVITPTVTPIatPPP 1057
                           90
                   ....*....|....*....
gi 1834395647  119 MAAKTPSSEESGLPKLPVP 137
Cdd:pfam15324 1058 AATPTPPLSENSIDKLKSP 1076
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH