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Conserved domains on  [gi|299782546|ref|NP_065206|]
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phosphatidylinositol N-acetylglucosaminyltransferase subunit A isoform 3 [Homo sapiens]

Protein Classification

glycosyltransferase family protein( domain architecture ID 56)

glycosyltransferase family protein may synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Glycosyltransferase_GTB-type super family cl10013
glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases ...
 5-198 8.73e-113

glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. The structures of the formed glycoconjugates are extremely diverse, reflecting a wide range of biological functions. The members of this family share a common GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.


The actual alignment was detected with superfamily member cd03796:

Pssm-ID: 471961 [Multi-domain]  Cd Length: 398  Bit Score: 329.20  E-value: 8.73e-113
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299782546   5 GIDLLSGIIPELCQKYPDLNFIIGGEGPKRIILEEVRERYQLHDRVRLLGALEHKDVRNVLVQGHIFLNTSLTEAFCMAI 84
Cdd:cd03796  207 GIDLLVGIIPRICKKHPNVRFIIGGDGPKRIELEEMREKYQLQDRVELLGAVPHEEVRDVLVQGHIFLNTSLTEAFCIAI 286

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299782546  85 VEAASCGLQVVSTRVGGIPEVLPENLIILCEPSVKSLCEGLEKAIFQLKSGTlPAPENIHNIVKTFYTWRNVAERTEKVY 164
Cdd:cd03796  287 VEAASCGLLVVSTRVGGIPEVLPPDMILLAEPDPEDIVRKLEEAISILRTGK-HDPWSFHNRVKKMYSWEDVARRTEKVY 365

                        170       180       190
                 ....*....|....*....|....*....|....
gi 299782546 165 DRVSVEAVLPMDKRLdRLISHCGPVTGYIFALLA 198
Cdd:cd03796  366 DRILSTPNRPFLERL-KRYYNCGPIAGKIFCLLA 398
 
Name Accession Description Interval E-value
GT4_PIG-A-like cd03796
phosphatidylinositol N-acetylglucosaminyltransferase subunit A and similar proteins; This ...
 5-198 8.73e-113

phosphatidylinositol N-acetylglucosaminyltransferase subunit A and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Phosphatidylinositol glycan-class A (PIG-A), an X-linked gene in humans, is necessary for the synthesis of N-acetylglucosaminyl-phosphatidylinositol, a very early intermediate in glycosyl phosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is an important cellular structure that facilitates the attachment of many proteins to cell surfaces. Somatic mutations in PIG-A have been associated with Paroxysmal Nocturnal Hemoglobinuria (PNH), an acquired hematological disorder.


Pssm-ID: 340827 [Multi-domain]  Cd Length: 398  Bit Score: 329.20  E-value: 8.73e-113
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299782546   5 GIDLLSGIIPELCQKYPDLNFIIGGEGPKRIILEEVRERYQLHDRVRLLGALEHKDVRNVLVQGHIFLNTSLTEAFCMAI 84
Cdd:cd03796  207 GIDLLVGIIPRICKKHPNVRFIIGGDGPKRIELEEMREKYQLQDRVELLGAVPHEEVRDVLVQGHIFLNTSLTEAFCIAI 286

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299782546  85 VEAASCGLQVVSTRVGGIPEVLPENLIILCEPSVKSLCEGLEKAIFQLKSGTlPAPENIHNIVKTFYTWRNVAERTEKVY 164
Cdd:cd03796  287 VEAASCGLLVVSTRVGGIPEVLPPDMILLAEPDPEDIVRKLEEAISILRTGK-HDPWSFHNRVKKMYSWEDVARRTEKVY 365

                        170       180       190
                 ....*....|....*....|....*....|....
gi 299782546 165 DRVSVEAVLPMDKRLdRLISHCGPVTGYIFALLA 198
Cdd:cd03796  366 DRILSTPNRPFLERL-KRYYNCGPIAGKIFCLLA 398
Glyco_trans_1_4 pfam13692
Glycosyl transferases group 1;
5-129 7.54e-22

Glycosyl transferases group 1;


Pssm-ID: 463957 [Multi-domain]  Cd Length: 138  Bit Score: 87.95  E-value: 7.54e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299782546    5 GIDLLSGIIPELCQKYPDLNFIIGGEGPKRIILEEVREryqLHDRVRLLGALEhkDVRNVLVQGHIFLNTSLTEAFCMAI 84
Cdd:pfam13692  16 GVDYLLEAVPLLRKRDNDVRLVIVGDGPEEELEELAAG---LEDRVIFTGFVE--DLAELLAAADVFVLPSLYEGFGLKL 90

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 299782546   85 VEAASCGLQVVSTRVGGIPEVLPENLIILCEP-SVKSLCEGLEKAI 129
Cdd:pfam13692  91 LEAMAAGLPVVATDVGGIPELVDGENGLLVPPgDPEALAEAILRLL 136
RfaB COG0438
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 69-167 4.78e-15

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440207 [Multi-domain]  Cd Length: 123  Bit Score: 69.25  E-value: 4.78e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299782546  69 HIFLNTSLTEAFCMAIVEAASCGLQVVSTRVGGIPEVLPENLI-ILCEP-SVKSLCEGLEKAifqLKSGTLPA--PENIH 144
Cdd:COG0438   22 DVFVLPSRSEGFGLVLLEAMAAGLPVIATDVGGLPEVIEDGETgLLVPPgDPEALAEAILRL---LEDPELRRrlGEAAR 98

                         90       100
                 ....*....|....*....|...
gi 299782546 145 NIVKTFYTWRNVAERTEKVYDRV 167
Cdd:COG0438   99 ERAEERFSWEAIAERLLALYEEL 121
PRK15484 PRK15484
lipopolysaccharide N-acetylglucosaminyltransferase;
78-163 2.70e-05

lipopolysaccharide N-acetylglucosaminyltransferase;


Pssm-ID: 185381 [Multi-domain]  Cd Length: 380  Bit Score: 44.78  E-value: 2.70e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299782546  78 EAFCMAIVEAASCGLQVVSTRVGGIPEVLPENLI--ILCEP-SVKSLCEGLEKAIfqLKSGTLPAPENIHNIVKTFYTWR 154
Cdd:PRK15484 288 EAFCMVAVEAMAAGKPVLASTKGGITEFVLEGITgyHLAEPmTSDSIISDINRTL--ADPELTQIAEQAKDFVFSKYSWE 365


                 ....*....
gi 299782546 155 NVAERTEKV 163
Cdd:PRK15484 366 GVTQRFEEQ 374
 
Name Accession Description Interval E-value
GT4_PIG-A-like cd03796
phosphatidylinositol N-acetylglucosaminyltransferase subunit A and similar proteins; This ...
 5-198 8.73e-113

phosphatidylinositol N-acetylglucosaminyltransferase subunit A and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Phosphatidylinositol glycan-class A (PIG-A), an X-linked gene in humans, is necessary for the synthesis of N-acetylglucosaminyl-phosphatidylinositol, a very early intermediate in glycosyl phosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is an important cellular structure that facilitates the attachment of many proteins to cell surfaces. Somatic mutations in PIG-A have been associated with Paroxysmal Nocturnal Hemoglobinuria (PNH), an acquired hematological disorder.


Pssm-ID: 340827 [Multi-domain]  Cd Length: 398  Bit Score: 329.20  E-value: 8.73e-113
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299782546   5 GIDLLSGIIPELCQKYPDLNFIIGGEGPKRIILEEVRERYQLHDRVRLLGALEHKDVRNVLVQGHIFLNTSLTEAFCMAI 84
Cdd:cd03796  207 GIDLLVGIIPRICKKHPNVRFIIGGDGPKRIELEEMREKYQLQDRVELLGAVPHEEVRDVLVQGHIFLNTSLTEAFCIAI 286

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299782546  85 VEAASCGLQVVSTRVGGIPEVLPENLIILCEPSVKSLCEGLEKAIFQLKSGTlPAPENIHNIVKTFYTWRNVAERTEKVY 164
Cdd:cd03796  287 VEAASCGLLVVSTRVGGIPEVLPPDMILLAEPDPEDIVRKLEEAISILRTGK-HDPWSFHNRVKKMYSWEDVARRTEKVY 365

                        170       180       190
                 ....*....|....*....|....*....|....
gi 299782546 165 DRVSVEAVLPMDKRLdRLISHCGPVTGYIFALLA 198
Cdd:cd03796  366 DRILSTPNRPFLERL-KRYYNCGPIAGKIFCLLA 398
GT4_PimA-like cd03801
phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 ...
 5-164 5.78e-25

phosphatidyl-myo-inositol mannosyltransferase; This family is most closely related to the GT4 family of glycosyltransferases and named after PimA in Propionibacterium freudenreichii, which is involved in the biosynthesis of phosphatidyl-myo-inositol mannosides (PIM) which are early precursors in the biosynthesis of lipomannans (LM) and lipoarabinomannans (LAM), and catalyzes the addition of a mannosyl residue from GDP-D-mannose (GDP-Man) to the position 2 of the carrier lipid phosphatidyl-myo-inositol (PI) to generate a phosphatidyl-myo-inositol bearing an alpha-1,2-linked mannose residue (PIM1). Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in certain bacteria and archaea.


Pssm-ID: 340831 [Multi-domain]  Cd Length: 366  Bit Score: 101.46  E-value: 5.78e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299782546   5 GIDLLSGIIPELCQKYPDLNF-IIGGEGPKRiilEEVRER-YQLHDRVRLLGALEHKDVRNVLVQGHIFLNTSLTEAFCM 82
Cdd:cd03801  206 GVDLLLEALAKLLRRGPDVRLvIVGGDGPLR---AELEELeLGLGDRVRFLGFVPDEELPALYAAADVFVLPSRYEGFGL 282

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299782546  83 AIVEAASCGLQVVSTRVGGIPEVLP--ENLIILCEPSVKSLCEGLEKAifqLKSGTLPAP--ENIHNIVKTFYTWRNVAE 158
Cdd:cd03801  283 VVLEAMAAGLPVVATDVGGLPEVVEdgEGGLVVPPDDVEALADALLRL---LADPELRARlgRAARERVAERFSWERVAE 359


                 ....*.
gi 299782546 159 RTEKVY 164
Cdd:cd03801  360 RLLDLY 365
Glyco_trans_1_4 pfam13692
Glycosyl transferases group 1;
5-129 7.54e-22

Glycosyl transferases group 1;


Pssm-ID: 463957 [Multi-domain]  Cd Length: 138  Bit Score: 87.95  E-value: 7.54e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299782546    5 GIDLLSGIIPELCQKYPDLNFIIGGEGPKRIILEEVREryqLHDRVRLLGALEhkDVRNVLVQGHIFLNTSLTEAFCMAI 84
Cdd:pfam13692  16 GVDYLLEAVPLLRKRDNDVRLVIVGDGPEEELEELAAG---LEDRVIFTGFVE--DLAELLAAADVFVLPSLYEGFGLKL 90

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 299782546   85 VEAASCGLQVVSTRVGGIPEVLPENLIILCEP-SVKSLCEGLEKAI 129
Cdd:pfam13692  91 LEAMAAGLPVVATDVGGIPELVDGENGLLVPPgDPEALAEAILRLL 136
Glycos_transf_1 pfam00534
Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease ...
 5-129 2.57e-20

Glycosyl transferases group 1; Mutations in this domain of Swiss:P37287 lead to disease (Paroxysmal Nocturnal haemoglobinuria). Members of this family transfer activated sugars to a variety of substrates, including glycogen, Fructose-6-phosphate and lipopolysaccharides. Members of this family transfer UDP, ADP, GDP or CMP linked sugars. The eukaryotic glycogen synthases may be distant members of this family.


Pssm-ID: 425737 [Multi-domain]  Cd Length: 158  Bit Score: 84.25  E-value: 2.57e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299782546    5 GIDLLSGIIPELCQKYPDLNFIIGGEGPKRIILEEVRERYQLHDRVRLLGALEHKDVRNVLVQGHIFLNTSLTEAFCMAI 84
Cdd:pfam00534  16 GLDLLIKAFALLKEKNPNLKLVIAGDGEEEKRLKKLAEKLGLGDNVIFLGFVSDEDLPELLKIADVFVLPSRYEGFGIVL 95

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 299782546   85 VEAASCGLQVVSTRVGGIPEVLPENLI-ILCEP-SVKSLCEGLEKAI 129
Cdd:pfam00534  96 LEAMACGLPVIASDVGGPPEVVKDGETgFLVKPnNAEALAEAIDKLL 142
GT4_WlbH-like cd03798
Bordetella parapertussis WlbH and similar proteins; This family is most closely related to the ...
 5-167 2.90e-20

Bordetella parapertussis WlbH and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Staphylococcus aureus CapJ may be involved in capsule polysaccharide biosynthesis. WlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core (band B), generates band A LPS.


Pssm-ID: 340828 [Multi-domain]  Cd Length: 376  Bit Score: 88.59  E-value: 2.90e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299782546   5 GIDLLSGIIPELCQKYPDLNFIIGGEGPKRIILEEVRERYQLHDRVRLLGALEHKDVRNVLVQGHIFLNTSLTEAFCMAI 84
Cdd:cd03798  214 GIDLLLEAFARLAKARPDVVLLIVGDGPLREALRALAEDLGLGDRVTFTGRLPHEQVPAYYRACDVFVLPSRHEGFGLVL 293

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299782546  85 VEAASCGLQVVSTRVGGIPEVL-PENLIILCEP-SVKSLCEGLEKAIfqLKSGTLPAPENIHNIVKTFYTWRNVAERTEK 162
Cdd:cd03798  294 LEAMACGLPVVATDVGGIPEVVgDPETGLLVPPgDADALAAALRRAL--AEPYLRELGEAARARVAERFSWVKAADRIAA 371


                 ....*
gi 299782546 163 VYDRV 167
Cdd:cd03798  372 AYRDV 376
GT4_WbnK-like cd03807
Shigella dysenteriae WbnK and similar proteins; This family is most closely related to the GT4 ...
 16-129 2.76e-18

Shigella dysenteriae WbnK and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis.


Pssm-ID: 340836 [Multi-domain]  Cd Length: 362  Bit Score: 82.75  E-value: 2.76e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299782546  16 LCQKYPDLNFIIGGEGPKRIILEEVRERYQLHDRVRLLGalEHKDVRNVLVQGHIFLNTSLTEAFCMAIVEAASCGLQVV 95
Cdd:cd03807  215 LVETHPDLRLLLVGRGPERPNLERLLLELGLEDRVHLLG--ERSDVPALLPAMDIFVLSSRTEGFPNALLEAMACGLPVV 292

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 299782546  96 STRVGGIPEVLPENLIILCEP-SVKSLCEGLEKAI 129
Cdd:cd03807  293 ATDVGGAAELVDDGTGFLVPAgDPQALADAIRALL 327
Glycosyltransferase_GTB-type cd01635
glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases ...
 5-109 1.09e-17

glycosyltransferase family 1 and related proteins with GTB topology; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. The structures of the formed glycoconjugates are extremely diverse, reflecting a wide range of biological functions. The members of this family share a common GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.


Pssm-ID: 340816 [Multi-domain]  Cd Length: 235  Bit Score: 79.37  E-value: 1.09e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299782546   5 GIDLLSGIIPELCQKYPDLNFIIGGEGPKRIILEEVRERYQLHDRVRLLGALEHKDVRNVLVQG-HIFLNTSLTEAFCMA 83
Cdd:cd01635  124 GIDLLLEALALLKARLPDLVLVLVGGGGEREEEEALAAALGLLERVVIIGGLVDDEVLELLLAAaDVFVLPSRSEGFGLV 203

                         90       100
                 ....*....|....*....|....*.
gi 299782546  84 IVEAASCGLQVVSTRVGGIPEVLPEN 109
Cdd:cd01635  204 LLEAMAAGKPVIATDVGGIPEFVVDG 229
GT4_GT28_WabH-like cd03811
family 4 and family 28 glycosyltransferases similar to Klebsiella WabH; This family is most ...
 5-133 3.41e-16

family 4 and family 28 glycosyltransferases similar to Klebsiella WabH; This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core.


Pssm-ID: 340839 [Multi-domain]  Cd Length: 351  Bit Score: 76.63  E-value: 3.41e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299782546   5 GIDLLSGIIPELCQKYPDLNFIIGGEGPKRIILEEVRERYQLHDRVRLLGalEHKDVRNVLVQGHIFLNTSLTEAFCMAI 84
Cdd:cd03811  202 GHDLLIEAFAKLRKKYPDVKLVILGDGPLREELEKLAKELGLAERVIFLG--FQSNPYPYLKKADLFVLSSRYEGFPNVL 279

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 299782546  85 VEAASCGLQVVSTRVGGIPEVLPENL-IILCEPSVKSLCEGLEKAIFQLK 133
Cdd:cd03811  280 LEAMALGTPVVSTDCPGPREILDDGEnGLLVPDGDAAALAGILAALLQKK 329
RfaB COG0438
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
 69-167 4.78e-15

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440207 [Multi-domain]  Cd Length: 123  Bit Score: 69.25  E-value: 4.78e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299782546  69 HIFLNTSLTEAFCMAIVEAASCGLQVVSTRVGGIPEVLPENLI-ILCEP-SVKSLCEGLEKAifqLKSGTLPA--PENIH 144
Cdd:COG0438   22 DVFVLPSRSEGFGLVLLEAMAAGLPVIATDVGGLPEVIEDGETgLLVPPgDPEALAEAILRL---LEDPELRRrlGEAAR 98

                         90       100
                 ....*....|....*....|...
gi 299782546 145 NIVKTFYTWRNVAERTEKVYDRV 167
Cdd:COG0438   99 ERAEERFSWEAIAERLLALYEEL 121
GT4_CapM-like cd03808
capsular polysaccharide biosynthesis glycosyltransferase CapM and similar proteins; This ...
 5-129 2.79e-14

capsular polysaccharide biosynthesis glycosyltransferase CapM and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. CapM in Staphylococcus aureus is required for the synthesis of type 1 capsular polysaccharides.


Pssm-ID: 340837 [Multi-domain]  Cd Length: 358  Bit Score: 71.09  E-value: 2.79e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299782546   5 GIDLLSGIIPELCQKYPDLNFIIGGEGPKRIILEEVRERYQLHDRVRLLGalEHKDVRNVLVQGHIFLNTSLTEAFCMAI 84
Cdd:cd03808  203 GIDELIEAAKILKKKGPNVRFLLVGDGELENPSEILIEKLGLEGRIEFLG--FRSDVPELLAESDVFVLPSYREGLPRSL 280

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 299782546  85 VEAASCGLQVVSTRVGGIPE-VLPENLIILCEP-SVKSLCEGLEKAI 129
Cdd:cd03808  281 LEAMAAGRPVITTDVPGCRElVIDGVNGFLVPPgDVEALADAIEKLI 327
GT4_AmsD-like cd03820
amylovoran biosynthesis glycosyltransferase AmsD and similar proteins; This family is most ...
 5-96 4.32e-14

amylovoran biosynthesis glycosyltransferase AmsD and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be responsible for the formation of galactose alpha-1,6 linkages in amylovoran.


Pssm-ID: 340847 [Multi-domain]  Cd Length: 351  Bit Score: 70.73  E-value: 4.32e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299782546   5 GIDLLSGIIPELCQKYPDLNFIIGGEGPKRIILEEVRERYQLHDRVRLLGALehKDVRNVLVQGHIFLNTSLTEAFCMAI 84
Cdd:cd03820  195 GFDLLIEAWALIAKKHPDWKLRIYGDGPEREELEKLIDKLGLEDRVKLLGPT--KNIAEEYANSSIFVLSSRYEGFPMVL 272

                         90
                 ....*....|..
gi 299782546  85 VEAASCGLQVVS 96
Cdd:cd03820  273 LEAMAYGLPIIS 284
GT4_WavL-like cd03819
Vibrio cholerae WavL and similar sequences; This family is most closely related to the GT4 ...
 5-116 1.07e-13

Vibrio cholerae WavL and similar sequences; This family is most closely related to the GT4 family of glycosyltransferases. WavL in Vibrio cholerae has been shown to be involved in the biosynthesis of the lipopolysaccharide core.


Pssm-ID: 340846 [Multi-domain]  Cd Length: 345  Bit Score: 69.31  E-value: 1.07e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299782546   5 GIDLLSGIIPELcQKYPDLNFIIGGEGPKRIILEEVRERYQLHDRVRLLGAleHKDVRNVLVQGHIFLNTSLTEAFCMAI 84
Cdd:cd03819  196 GWLLLVDAAAEL-KDEPDFRLLVAGDGPERDEIRRLVERLGLRDRVTFTGF--REDVPAALAASDVVVLPSLHEEFGRVA 272

                         90       100       110
                 ....*....|....*....|....*....|..
gi 299782546  85 VEAASCGLQVVSTRVGGIPEVLPENLIILCEP 116
Cdd:cd03819  273 LEAMACGTPVVATDVGGAREIVVHGRTGLLVP 304
GT4_AmsK-like cd03799
Erwinia amylovora AmsK and similar proteins; This is a family of GT4 glycosyltransferases ...
 16-110 1.70e-13

Erwinia amylovora AmsK and similar proteins; This is a family of GT4 glycosyltransferases found specifically in certain bacteria. AmsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor.


Pssm-ID: 340829 [Multi-domain]  Cd Length: 350  Bit Score: 69.02  E-value: 1.70e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299782546  16 LCQKYPDLNFIIGGEGPKRIILEEVRERYQLHDRVRLLGALEHKDVRNVLVQGHIFLNTSLT------EAFCMAIVEAAS 89
Cdd:cd03799  199 LAQKYPNIEYQIIGDGDLKEQLQQLIQELNIGDCVKLLGWKPQEEIIEILDEADIFIAPSVTaadgdqDGPPNTLKEAMA 278

                         90       100
                 ....*....|....*....|.
gi 299782546  90 CGLQVVSTRVGGIPEVLPENL 110
Cdd:cd03799  279 MGLPVISTEHGGIPELVEDGV 299
GT4_BshA-like cd04962
N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA and similar proteins; This family is most ...
 29-109 1.93e-13

N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria, while some of them are also found in Archaea and eukaryotes.


Pssm-ID: 340859 [Multi-domain]  Cd Length: 370  Bit Score: 68.92  E-value: 1.93e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299782546  29 GEGPKRIILEEVRERYQLHDRVRLLGALEHkdVRNVLVQGHIFLNTSLTEAFCMAIVEAASCGLQVVSTRVGGIPEVLPE 108
Cdd:cd04962  233 GDGPERVPAEELARELGVEDRVLFLGKQDD--VEELLSIADLFLLPSEKESFGLAALEAMACGVPVVSSNAGGIPEVVKH 310


                 .
gi 299782546 109 N 109
Cdd:cd04962  311 G 311
GT4_WbdM_like cd04951
LPS/UnPP-GlcNAc-Gal a-1,4-glucosyltransferase WbdM and similar proteins; This family is most ...
 13-112 3.14e-13

LPS/UnPP-GlcNAc-Gal a-1,4-glucosyltransferase WbdM and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases and is named after WbdM in Escherichia coli. In general glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found in bacteria.


Pssm-ID: 340857 [Multi-domain]  Cd Length: 360  Bit Score: 68.24  E-value: 3.14e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299782546  13 IPELCQKYPDLNFIIGGEGPKRIILEEVRERYQLHDRVRLLGAleHKDVRNVLVQGHIFLNTSLTEAFCMAIVEAASCGL 92
Cdd:cd04951  210 ISELILSKNDFKLLIAGDGPLRNELERLICNLNLVDRVILLGQ--ISNISEYYNAADLFVLSSEWEGFGLVVAEAMACER 287

                         90       100
                 ....*....|....*....|.
gi 299782546  93 QVVSTRVGGIPEVL-PENLII 112
Cdd:cd04951  288 PVVATDAGGVAEVVgDHNYVV 308
GT4_sucrose_synthase cd03800
sucrose-phosphate synthase and similar proteins; This family is most closely related to the ...
 5-161 7.22e-13

sucrose-phosphate synthase and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose 6-phosphate and uridine 5'-diphosphate-glucose, a key regulatory step of sucrose metabolism. The activity of this enzyme is regulated by phosphorylation and moderated by the concentration of various metabolites and light.


Pssm-ID: 340830 [Multi-domain]  Cd Length: 398  Bit Score: 67.27  E-value: 7.22e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299782546   5 GIDLL---SGIIPELCQkypDLNFIIGGeGPKRIILEEVRE-------RYQLHDRVRLLGALEHKDVRNVLVQGHIFLNT 74
Cdd:cd03800  234 GIDTLvraFAQLPELRE---LANLVLVG-GPSDDPLSMDREelaelaeELGLIDRVRFPGRVSRDDLPELYRAADVFVVP 309

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299782546  75 SLTEAFCMAIVEAASCGLQVVSTRVGGIPE-VLPENLIILCEP-SVKSLCEGLEKaIFQLKSGTLPAPENIHNIVKTFYT 152
Cdd:cd03800  310 SLYEPFGLTAIEAMACGTPVVATAVGGLQDiVRDGRTGLLVDPhDPEALAAALRR-LLDDPALWQRLSRAGLERARAHYT 388


                 ....*....
gi 299782546 153 WRNVAERTE 161
Cdd:cd03800  389 WESVADQLL 397
GT4_UGDG-like cd03817
UDP-Glc:1,2-diacylglycerol 3-a-glucosyltransferase and similar proteins; This family is most ...
 6-167 1.06e-12

UDP-Glc:1,2-diacylglycerol 3-a-glucosyltransferase and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (EC 2.4.1.337, UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1,2-diacylglycerol forming 3-D-glucosyl-1,2-diacylglycerol.


Pssm-ID: 340844 [Multi-domain]  Cd Length: 372  Bit Score: 66.53  E-value: 1.06e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299782546   6 IDLLSGIIPELCQKyPDLNFIIGGEGPKRIILEEVRERYQLHDRVRLLGALEHKDVRNVLVQGHIFLNTSLTEAFCMAIV 85
Cdd:cd03817  216 IDFLLRAFAELKKE-PNIKLVIVGDGPEREELKELARELGLADKVIFTGFVPREELPEYYKAADLFVFASTTETQGLVYL 294

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299782546  86 EAASCGLQVVSTRVGGIPEVLpENLI--ILCEPSVKSLCEGLEKAIFQLKSGTLPApENIHNIVKTFytwrNVAERTEKV 163
Cdd:cd03817  295 EAMAAGLPVVAAKDPAASELV-EDGEngFLFEPNDETLAEKLLHLRENLELLRKLS-KNAEISAREF----AFAKSVEKL 368


                 ....
gi 299782546 164 YDRV 167
Cdd:cd03817  369 YEEV 372
GT4-like cd05844
glycosyltransferase family 4 proteins; Glycosyltransferases catalyze the transfer of sugar ...
 2-104 3.28e-12

glycosyltransferase family 4 proteins; Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to glycosyltransferase family 4 (GT4). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility.


Pssm-ID: 340860 [Multi-domain]  Cd Length: 365  Bit Score: 65.17  E-value: 3.28e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299782546   2 ELTGIDLLSGIIPELCQKYPDLNFIIGGEGPKRIILEEVRERYqlhDRVRLLGALEHKDVRNVLVQGHIFLNTSLT---- 77
Cdd:cd05844  200 EKKGCDVLIEAFRRLAARHPTARLVIAGDGPLRPALQALAAAL---GRVRFLGALPHAEVQDWMRRAEIFCLPSVTaasg 276

                         90       100
                 ....*....|....*....|....*....
gi 299782546  78 --EAFCMAIVEAASCGLQVVSTRVGGIPE 104
Cdd:cd05844  277 dsEGLGIVLLEAAACGVPVVSSRHGGIPE 305
GT4_Bme6-like cd03821
Brucella melitensis Bme6 and similar proteins; This family is most closely related to the GT4 ...
 5-161 3.57e-12

Brucella melitensis Bme6 and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide.


Pssm-ID: 340848 [Multi-domain]  Cd Length: 377  Bit Score: 65.08  E-value: 3.57e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299782546   5 GIDLLSGIIPELCQKYPDLNFIIGGEGPKriiLEEVRERYQ----LHDRVRLLGALEHKDVRNVLVQGHIFLNTSLTEAF 80
Cdd:cd03821  218 GLDLLIRAARKLAEQGRDWHLVIAGPDDG---AYPAFLQLQsslgLGDRVTFTGPLYGEAKWALYASADLFVLPSYSENF 294

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299782546  81 CMAIVEAASCGLQVVSTRVGGIPEVLPENLIILCEPSVKSLCEGLEKAIfQLKSGTLPAPENIHNIVKT--FYTWRNVAE 158
Cdd:cd03821  295 GNVVAEALACGLPVVITDKCGLSELVEAGCGVVVDPNVSSLAEALAEAL-RDPADRKRLGEMARRARQVeeNFSWEAVAG 373


                 ...
gi 299782546 159 RTE 161
Cdd:cd03821  374 QLG 376
GT4_MtfB-like cd03809
glycosyltransferases MtfB, WbpX, and similar proteins; This family is most closely related to ...
 19-162 6.62e-12

glycosyltransferases MtfB, WbpX, and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. MtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the previously synthesized polysaccharide.


Pssm-ID: 340838 [Multi-domain]  Cd Length: 362  Bit Score: 64.31  E-value: 6.62e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299782546  19 KYPDLN-FIIGGEGPKRIILEEVRERYQLHDRVRLLGALEHKDVRNVLVQGHIFLNTSLTEAFCMAIVEAASCGLQVVST 97
Cdd:cd03809  220 QGGDLKlVIVGGKGWEDEELLDLVKKLGLGGRVRFLGYVSDEDLPALYRGARAFVFPSLYEGFGLPVLEAMACGTPVIAS 299

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 299782546  98 RVGGIPEVLPENlIILCEP-SVKSLCEGLEKAIFQlKSGTLPAPENIHNIVKTFyTWRNVAERTEK 162
Cdd:cd03809  300 NISVLPEVAGDA-ALYFDPlDPESIADAILRLLED-PSLREELIRKGLERAKKF-SWEKTAEKTLE 362
GT4_AmsK-like cd04946
amylovoran biosynthesis glycosyltransferase AmsK and similar proteins; This family is most ...
 6-129 4.63e-10

amylovoran biosynthesis glycosyltransferase AmsK and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. AmsK is involved in the biosynthesis of amylovoran, which functions as a virulence factor. It functions as a glycosyl transferase which transfers galactose from UDP-galactose to a lipid-linked amylovoran-subunit precursor. The members of this family are found mainly in bacteria and Archaea.


Pssm-ID: 340854 [Multi-domain]  Cd Length: 401  Bit Score: 59.01  E-value: 4.63e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299782546   6 IDLLSGIIPELCQKYPDLNFI---IGGeGPKRIILEEVRERYQLHDRVRLLGALEHKDVRNVLVQG--HIFLNTSLTEAF 80
Cdd:cd04946  239 IDLIIETLNSLCVAHPSICISwthIGG-GPLKERLEKLAENKLENVKVNFTGEVSNKEVKQLYKENdvDVFVNVSESEGI 317

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 299782546  81 CMAIVEAASCGLQVVSTRVGGIPEVLpEN----LIILCEPSVKSLCEGLEKAI 129
Cdd:cd04946  318 PVSIMEAISFGIPVIATNVGGTREIV-ENetngLLLDKDPTPNEIVSSIMKFY 369
GT4-like cd03814
glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family ...
 5-108 1.46e-09

glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family of glycosyltransferases and includes a sequence annotated as alpha-D-mannose-alpha(1-6)phosphatidyl myo-inositol monomannoside transferase from Bacillus halodurans. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria and eukaryotes.


Pssm-ID: 340842 [Multi-domain]  Cd Length: 365  Bit Score: 57.30  E-value: 1.46e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299782546   5 GIDLLSGIIPELCQKYPdLNFIIGGEGPKRiilEEVRERYqlhDRVRLLGALEHKDVRNVLVQGHIFLNTSLTEAFCMAI 84
Cdd:cd03814  212 NLEALLDADLPLAASPP-VRLVVVGDGPAR---AELEARG---PDVIFTGFLTGEELARAYASADVFVFPSRTETFGLVV 284

                         90       100
                 ....*....|....*....|....
gi 299782546  85 VEAASCGLQVVSTRVGGIPEVLPE 108
Cdd:cd03814  285 LEAMASGLPVVAADAGGPRDIVRP 308
GT4_ExpE7-like cd03823
glycosyltransferase ExpE7 and similar proteins; This family is most closely related to the GT4 ...
 5-164 4.06e-08

glycosyltransferase ExpE7 and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II).


Pssm-ID: 340850 [Multi-domain]  Cd Length: 357  Bit Score: 53.10  E-value: 4.06e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299782546   5 GIDLLSgiipELCQKYPDLN--FIIGGEGPKRIIleevrERYQLHDRVRLLGALEHKDVRNVLVQGHIFLNTSL-TEAFC 81
Cdd:cd03823  205 GIDLLV----EAFKRLPREDieLVIAGHGPLSDE-----RQIEGGRRIAFLGRVPTDDIKDFYEKIDVLVVPSIwPEPFG 275

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299782546  82 MAIVEAASCGLQVVSTRVGGIPE-VLPENLIILCEPSVKslcEGLEKAIFQL-KSGTLPAPENIHNIVKTFYTWRnvAER 159
Cdd:cd03823  276 LVVREAIAAGLPVIASDLGGIAElIQPGVNGLLFAPGDA---EDLAAAMRRLlTDPALLERLRAGAEPPRSTESQ--AEE 350


                 ....*
gi 299782546 160 TEKVY 164
Cdd:cd03823  351 YLKLY 355
GT4_WfcD-like cd03795
Escherichia coli alpha-1,3-mannosyltransferase WfcD and similar proteins; This family is most ...
 19-101 4.65e-08

Escherichia coli alpha-1,3-mannosyltransferase WfcD and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP-linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria and eukaryotes.


Pssm-ID: 340826 [Multi-domain]  Cd Length: 355  Bit Score: 53.05  E-value: 4.65e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299782546  19 KYPDLNFIIGGEGPKRIILEEVRErYQLHDRVRLLGALEHKDVRNVLVQGHIFLNTSL--TEAFCMAIVEAASCGLQVVS 96
Cdd:cd03795  214 QYLNYPIVIGGEGPLKPDLEAQIE-LNLLDNVKFLGRVDDEEKVIYLHLCDVFVFPSVlrSEAFGIVLLEAMMCGKPVIS 292


                 ....*
gi 299782546  97 TRVGG 101
Cdd:cd03795  293 TNIGT 297
GT4_GtfA-like cd04949
accessory Sec system glycosyltransferase GtfA and similar proteins; This family is most ...
 6-99 2.64e-07

accessory Sec system glycosyltransferase GtfA and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In general glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found in bacteria.


Pssm-ID: 340855 [Multi-domain]  Cd Length: 328  Bit Score: 50.38  E-value: 2.64e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299782546   6 IDLLSGIIPELCQKYPDLNFIIGGEGPKRIILEEVRERYQLHDRVRLLGAleHKDVRNVLVQGHIFLNTSLTEAFCMAIV 85
Cdd:cd04949  175 LDHLIEAVAKAVKKVPEITLDIYGYGEEREKLKKLIEELHLEDNVFLKGY--HSNLDQEYQDAYLSLLTSQMEGFGLTLM 252

                         90
                 ....*....|....
gi 299782546  86 EAASCGLQVVSTRV 99
Cdd:cd04949  253 EAIGHGLPVVSYDV 266
GT4-like cd03813
glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family ...
 21-106 3.31e-07

glycosyltransferase family 4 proteins; This family is most closely related to the GT4 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate residue. This group of glycosyltransferases is most closely related to the previously defined glycosyltransferase family 1 (GT1). The members of this family may transfer UDP, ADP, GDP, or CMP linked sugars. The diverse enzymatic activities among members of this family reflect a wide range of biological functions. The protein structure available for this family has the GTB topology, one of the two protein topologies observed for nucleotide-sugar-dependent glycosyltransferases. GTB proteins have distinct N- and C- terminal domains each containing a typical Rossmann fold. The two domains have high structural homology despite minimal sequence homology. The large cleft that separates the two domains includes the catalytic center and permits a high degree of flexibility. The members of this family are found mainly in bacteria, while some of them are also found in Archaea and eukaryotes.


Pssm-ID: 340841 [Multi-domain]  Cd Length: 474  Bit Score: 50.41  E-value: 3.31e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299782546  21 PDLNF-IIGGEGPKRIILEEVRERYQ---LHDRVRLLGaleHKDVRNVLVQGHIFLNTSLTEAFCMAIVEAASCGLQVVS 96
Cdd:cd03813  323 PDAEGwLIGPEDEDPEYAQECKRLVAslgLENKVKFLG---FQNIKEYYPKLGLLVLTSISEGQPLVILEAMASGVPVVA 399

                         90
                 ....*....|
gi 299782546  97 TRVGGIPEVL 106
Cdd:cd03813  400 TDVGSCRELI 409
PRK15484 PRK15484
lipopolysaccharide N-acetylglucosaminyltransferase;
78-163 2.70e-05

lipopolysaccharide N-acetylglucosaminyltransferase;


Pssm-ID: 185381 [Multi-domain]  Cd Length: 380  Bit Score: 44.78  E-value: 2.70e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299782546  78 EAFCMAIVEAASCGLQVVSTRVGGIPEVLPENLI--ILCEP-SVKSLCEGLEKAIfqLKSGTLPAPENIHNIVKTFYTWR 154
Cdd:PRK15484 288 EAFCMVAVEAMAAGKPVLASTKGGITEFVLEGITgyHLAEPmTSDSIISDINRTL--ADPELTQIAEQAKDFVFSKYSWE 365


                 ....*....
gi 299782546 155 NVAERTEKV 163
Cdd:PRK15484 366 GVTQRFEEQ 374
PLN02871 PLN02871
UDP-sulfoquinovose:DAG sulfoquinovosyltransferase
 15-108 9.29e-05

UDP-sulfoquinovose:DAG sulfoquinovosyltransferase


Pssm-ID: 215469 [Multi-domain]  Cd Length: 465  Bit Score: 43.16  E-value: 9.29e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299782546  15 ELCQKYPDLNFIIGGEGPKRIILEEVRERYQLHdrvrLLGALEHKDVRNVLVQGHIFLNTSLTEAFCMAIVEAASCGLQV 94
Cdd:PLN02871 283 RVMERLPGARLAFVGDGPYREELEKMFAGTPTV----FTGMLQGDELSQAYASGDVFVMPSESETLGFVVLEAMASGVPV 358

                         90
                 ....*....|....
gi 299782546  95 VSTRVGGIPEVLPE 108
Cdd:PLN02871 359 VAARAGGIPDIIPP 372
GT4_WcaC-like cd03825
putative colanic acid biosynthesis glycosyl transferase WcaC and similar proteins; This family ...
 26-126 1.25e-04

putative colanic acid biosynthesis glycosyl transferase WcaC and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. Escherichia coli WcaC has been predicted to function in colanic acid biosynthesis. WcfI in Bacteroides fragilis has been shown to be involved in the capsular polysaccharide biosynthesis.


Pssm-ID: 340851 [Multi-domain]  Cd Length: 364  Bit Score: 42.70  E-value: 1.25e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299782546  26 IIGGEGPKRIILE-EVRERYQLHDRVRLlgalehkdvRNVLVQGHIFLNTSLTEAFCMAIVEAASCGLQVVSTRVGGIPE 104
Cdd:cd03825  230 VFGKNDPQIVILPfDIISLGYIDDDEQL---------VDIYSAADLFVHPSLADNLPNTLLEAMACGTPVVAFDTGGSPE 300

                         90       100
                 ....*....|....*....|....
gi 299782546 105 VL--PENLIILCEPSVKSLCEGLE 126
Cdd:cd03825  301 IVqhGVTGYLVPPGDVQALAEAIE 324
GT4_AviGT4-like cd03802
UDP-Glc:tetrahydrobiopterin alpha-glucosyltransferase and similar proteins; This family is ...
 48-167 1.50e-04

UDP-Glc:tetrahydrobiopterin alpha-glucosyltransferase and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant that accumulated a novel avilamycin derivative lacking the terminal eurekanate residue.


Pssm-ID: 340832 [Multi-domain]  Cd Length: 333  Bit Score: 42.27  E-value: 1.50e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299782546  48 DRVRLLGALEHKDVRNVLVQGHIFLNTSL-TEAFCMAIVEAASCGLQVVSTRVGGIPEVLPENLI-ILCEPSvkslcEGL 125
Cdd:cd03802  220 PRIEFIGEVGHDEKQELLGGARALLFPINwDEPFGLVMIEAMACGTPVIAYRRGGLPEVIQHGETgFLVDSV-----EEM 294

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 299782546 126 EKAIfqLKSGTLPaPENIHNIVKTFYTWRNVAERTEKVYDRV 167
Cdd:cd03802  295 AEAI--ANIDRID-RAACRRYAEDRFSAARMADRYEALYRKV 333
PRK15179 PRK15179
Vi polysaccharide biosynthesis protein TviE; Provisional
 15-110 2.17e-04

Vi polysaccharide biosynthesis protein TviE; Provisional


Pssm-ID: 185101 [Multi-domain]  Cd Length: 694  Bit Score: 42.33  E-value: 2.17e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299782546  15 ELCQKY----PDLNFIIGGEGPkriILEEVRE---RYQLHDRVRLLGALEHkdVRNVLVQGHIFLNTSLTEAFCMAIVEA 87
Cdd:PRK15179 537 EAAQRFaashPKVRFIMVGGGP---LLESVREfaqRLGMGERILFTGLSRR--VGYWLTQFNAFLLLSRFEGLPNVLIEA 611

                         90       100
                 ....*....|....*....|...
gi 299782546  88 ASCGLQVVSTRVGGIPEVLPENL 110
Cdd:PRK15179 612 QFSGVPVVTTLAGGAGEAVQEGV 634
GT4_CapH-like cd03812
capsular polysaccharide biosynthesis glycosyltransferase CapH and similar proteins; This ...
 12-95 9.06e-04

capsular polysaccharide biosynthesis glycosyltransferase CapH and similar proteins; This family is most closely related to the GT4 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1).


Pssm-ID: 340840 [Multi-domain]  Cd Length: 357  Bit Score: 39.97  E-value: 9.06e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299782546  12 IIPELCQKYPDLNFIIGGEGPKRI-ILEEVRERyQLHDRVRLLGalEHKDVRNVLVQGHIFLNTSLTEAFCMAIVEAASC 90
Cdd:cd03812  212 IFEELKKKNPNVKLVLVGEGELKEkIKEKVKEL-GLEDKVIFLG--FRNDVSEILSAMDVFLFPSLYEGLPLVAVEAQAS 288


                 ....*
gi 299782546  91 GLQVV 95
Cdd:cd03812  289 GLPCL 293
GT4_WbuB-like cd03794
Escherichia coli WbuB and similar proteins; This family is most closely related to the GT1 ...
 5-161 2.27e-03

Escherichia coli WbuB and similar proteins; This family is most closely related to the GT1 family of glycosyltransferases. WbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase.


Pssm-ID: 340825 [Multi-domain]  Cd Length: 391  Bit Score: 38.86  E-value: 2.27e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299782546   5 GIDLLSGIIPELcQKYPDLNFIIGGEGPKRIILEEVRERYQLhDRVRLLGALEHKDVRNVLVQGHIFLNTSLTEAFCMAI 84
Cdd:cd03794  231 GLETLLEAAERL-KRRPDIRFLFVGDGDEKERLKELAKARGL-DNVTFLGRVPKEEVPELLSAADVGLVPLKDNPANRGS 308

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299782546  85 V-----EAASCGLQVVSTRVGGIPE-VLPENLIILCEP-SVkslcEGLEKAIFQLKS--------GtlpapENIHNIVKT 149
Cdd:cd03794  309 SpsklfEYMAAGKPILASDDGGSDLaVEINGCGLVVEPgDP----EALADAILELLDdpelrramG-----ENGRELAEE 379

                        170
                 ....*....|..
gi 299782546 150 FYTWRNVAERTE 161
Cdd:cd03794  380 KFSREKLADRLL 391
GT4_trehalose_phosphorylase cd03792
trehalose phosphorylase and similar proteins; Trehalose phosphorylase (TP) reversibly ...
 15-103 4.42e-03

trehalose phosphorylase and similar proteins; Trehalose phosphorylase (TP) reversibly catalyzes trehalose synthesis and degradation from alpha-glucose-1-phosphate (alpha-Glc-1-P) and glucose. The catalyzing activity includes the phosphorolysis of trehalose, which produce alpha-Glc-1-P and glucose, and the subsequent synthesis of trehalose. This family is most closely related to the GT4 family of glycosyltransferases.


Pssm-ID: 340823 [Multi-domain]  Cd Length: 378  Bit Score: 37.69  E-value: 4.42e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299782546  15 ELCQKYPDLNFIIGGEGPKR-----IILEEVRERYQLHDRVRLLGALEHKDVRNVLVQG-HIFLNTSLTEAFCMAIVEAA 88
Cdd:cd03792  221 LFKRRAEEPQLVICGHGAVDdpegsVVYEEVMEYAGDDHDIHVLRLPPSDQEINALQRAaTVVLQLSTREGFGLTVSEAL 300

                         90
                 ....*....|....*
gi 299782546  89 SCGLQVVSTRVGGIP 103
Cdd:cd03792  301 WKGKPVIATPAGGIP 315
PRK15490 PRK15490
Vi polysaccharide biosynthesis glycosyltransferase TviE;
18-110 6.87e-03

Vi polysaccharide biosynthesis glycosyltransferase TviE;


Pssm-ID: 185387 [Multi-domain]  Cd Length: 578  Bit Score: 37.37  E-value: 6.87e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 299782546  18 QKYPDLNFIIGGEGPKRIILEEVRERYQLHDRVRLLGAleHKDVRNVLVQGHIFLNTSLTEAFCMAIVEAASCGLQVVST 97
Cdd:PRK15490 425 QHHPATRFVLVGDGDLRAEAQKRAEQLGILERILFVGA--SRDVGYWLQKMNVFILFSRYEGLPNVLIEAQMVGVPVIST 502

                         90
                 ....*....|...
gi 299782546  98 RVGGIPEVLPENL 110
Cdd:PRK15490 503 PAGGSAECFIEGV 515
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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