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Conserved domains on  [gi|30794376|ref|NP_065171|]
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dolichyldiphosphatase 1 isoform a [Homo sapiens]

Protein Classification

phosphatase PAP2 family protein( domain architecture ID 10130181)

type 2 phosphatidic acid phosphatase (PAP2) family protein similar to dolichyldiphosphatase, a membrane-associated protein located in the endoplasmic reticulum that hydrolyzes dolichyl pyrophosphate, as well as dolichylmonophosphate at a low rate

CATH:  1.20.144.10
EC:  3.1.3.-
Gene Ontology:  GO:0016791|GO:0016311|GO:0008610
PubMed:  12447906|9260289
SCOP:  4001226

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PAP2_dolichyldiphosphatase cd03382
PAP2_like proteins, dolichyldiphosphatase subfamily. Dolichyldiphosphatase is a ...
 16-180 4.05e-71

PAP2_like proteins, dolichyldiphosphatase subfamily. Dolichyldiphosphatase is a membrane-associated protein located in the endoplasmic reticulum and hydrolyzes dolichyl pyrophosphate, as well as dolichylmonophosphate at a low rate. The enzyme is necessary for maintaining proper levels of dolichol-linked oligosaccharides and protein N-glycosylation, and might play a role in re-utilization of the glycosyl carrier lipid for additional rounds of lipid intermediate biosynthesis after its release during protein N-glycosylation reactions.


:

Pssm-ID: 239477  Cd Length: 159  Bit Score: 214.45  E-value: 4.05e-71
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30794376  16 VTLTHVEYPAGDLSGHLLAYLSLSPVFVIVGFVTLIIFKRELHTISFLGGLALNEGVNWLIKNVIQEPRPCgGPHTAVGT 95
Cdd:cd03382   1 FSLTHVLYDPGDLLSFLLAYLSLLPVAILVGYATLILFRRELEAIYLFIGLLANEALNYVLKRIIKEPRPC-SGAYFVRS 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30794376  96 KYGMPSSHSQFMWFFSVYSFLFLYLRMHQTNnarflDLLWRHVLSLGLLAVAFLVSYSRVYLLYHTWSQVLYGGIAGGLM 175
Cdd:cd03382  80 GYGMPSSHSQFMGFFAVYLLLFIYLRLGRLN-----SLVSRFLLSLGLLLLALLVSYSRVYLGYHTVSQVVVGAIVGILL 154


                ....*
gi 30794376 176 AIAWF 180
Cdd:cd03382 155 GILWF 159
 
Name Accession Description Interval E-value
PAP2_dolichyldiphosphatase cd03382
PAP2_like proteins, dolichyldiphosphatase subfamily. Dolichyldiphosphatase is a ...
 16-180 4.05e-71

PAP2_like proteins, dolichyldiphosphatase subfamily. Dolichyldiphosphatase is a membrane-associated protein located in the endoplasmic reticulum and hydrolyzes dolichyl pyrophosphate, as well as dolichylmonophosphate at a low rate. The enzyme is necessary for maintaining proper levels of dolichol-linked oligosaccharides and protein N-glycosylation, and might play a role in re-utilization of the glycosyl carrier lipid for additional rounds of lipid intermediate biosynthesis after its release during protein N-glycosylation reactions.


Pssm-ID: 239477  Cd Length: 159  Bit Score: 214.45  E-value: 4.05e-71
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30794376  16 VTLTHVEYPAGDLSGHLLAYLSLSPVFVIVGFVTLIIFKRELHTISFLGGLALNEGVNWLIKNVIQEPRPCgGPHTAVGT 95
Cdd:cd03382   1 FSLTHVLYDPGDLLSFLLAYLSLLPVAILVGYATLILFRRELEAIYLFIGLLANEALNYVLKRIIKEPRPC-SGAYFVRS 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30794376  96 KYGMPSSHSQFMWFFSVYSFLFLYLRMHQTNnarflDLLWRHVLSLGLLAVAFLVSYSRVYLLYHTWSQVLYGGIAGGLM 175
Cdd:cd03382  80 GYGMPSSHSQFMGFFAVYLLLFIYLRLGRLN-----SLVSRFLLSLGLLLLALLVSYSRVYLGYHTVSQVVVGAIVGILL 154


                ....*
gi 30794376 176 AIAWF 180
Cdd:cd03382 155 GILWF 159
PAP2 pfam01569
PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), ...
 61-184 6.00e-15

PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), Glucose-6-phosphatase EC:3.1.3.9, Phosphatidylglycerophosphatase B EC:3.1.3.27 and bacterial acid phosphatase EC:3.1.3.2. The family also includes a variety of haloperoxidases that function by oxidising halides in the presence of hydrogen peroxide to form the corresponding hypohalous acids.


Pssm-ID: 426329 [Multi-domain]  Cd Length: 124  Bit Score: 68.99  E-value: 6.00e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30794376    61 SFLGGLALNEGVNWLIKNVIQEPRP-----CGGPHTAVGT----KYGMPSSHSQFMWFFSVYSFLFLylrmhqtnnaRFL 131
Cdd:pfam01569   1 ILLLALALAGLLSSVLKDYFGRPRPfflllEGGLVPAPSTlpglGYSFPSGHSATAFALALLLALLL----------RRL 70

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 30794376   132 DLLWRHVLSLGLLAVAFLVSYSRVYLLYHTWSQVLYGGIAGGLMAIAWFIFTQ 184
Cdd:pfam01569  71 RKIVRVLLALLLLVLALLVGLSRLYLGVHFPSDVLAGALIGILLALLVYRLVP 123
acidPPc smart00014
Acid phosphatase homologues;
65-180 1.51e-12

Acid phosphatase homologues;


Pssm-ID: 214471 [Multi-domain]  Cd Length: 116  Bit Score: 62.36  E-value: 1.51e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30794376     65 GLALNEGVNWLIKNVIQEPRP--------CGGPHTAVGTK--YGMPSSHSQFMWFFSVYSFLFLYLRMHqtnnarfldll 134
Cdd:smart00014   3 LAVVSQLFNGVIKNYFGRPRPfflsigdaCCTPNFLLTLEagYSFPSGHTAFAFAFALFLLLYLPARAG----------- 71

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 30794376    135 wRHVLSLGLLAVAFLVSYSRVYLLYHTWSQVLYGGIAGGLMAIAWF 180
Cdd:smart00014  72 -RKLLIFLLLLLALVVGFSRVYLGAHWPSDVLAGSLLGILIAAVLF 116
PgpB COG0671
Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; ...
 9-184 4.80e-07

Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; Membrane-associated phospholipid phosphatase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 440435 [Multi-domain]  Cd Length: 189  Bit Score: 48.50  E-value: 4.80e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30794376   9 LPASWRPVTLTHVEYPAGDLSGHLLAYLSLSPVFVIVGFVTLIIFKRELHTISFLGGLALNEGVNWLIKNVIQEPRPCGG 88
Cdd:COG0671  25 LALLLLLALLLLLLLLLALLLILLLLLLLLLLLLLLLLLLLRLLALLLLLLLLAALLLLLLLLLLLLLKYLFGRPRPFVV 104

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30794376  89 P----HTAVGTKYGMPSSHSqfMWFFSVYSFLFLylrmhqtnnarfldLLWRHVLSLGLLAVAFLVSYSRVYLLYHTWSQ 164
Cdd:COG0671 105 PdlelLLGTAGGYSFPSGHA--AAAFALALVLAL--------------LLPRRWLAALLLALALLVGLSRVYLGVHYPSD 168

                       170       180
                ....*....|....*....|
gi 30794376 165 VLYGGIAGGLMAIAWFIFTQ 184
Cdd:COG0671 169 VLAGALLGLAIALLLLALLR 188
PLN02525 PLN02525
phosphatidic acid phosphatase family protein
 76-202 3.98e-04

phosphatidic acid phosphatase family protein


Pssm-ID: 215288  Cd Length: 352  Bit Score: 40.88  E-value: 3.98e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30794376   76 IKNVIQEPRPCGGP---HTAVGTK------YGMPSSHSQFMWFFSVYsfLFLYLRMHQTN-NARfldlLWRHVLSLGLLA 145
Cdd:PLN02525  54 IKDVVSAPRPSCPPvrrVTATKDEeenameYGLPSSHTLNTVCLSGY--LLHYVLSYLQNvDAS----VIFAGLALFCLL 127

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 30794376  146 VAfLVSYSRVYLLYHTWSQVlYGGIAGGLMAIA-W---------FIFTQEVLTPLFPRIA-----AWPVSEF 202
Cdd:PLN02525 128 VA-LVGFGRLYLGMHSPIDI-IAGLAIGLVILAfWltvdeyvdaFITSGQNVTPFWAALSflllfAYPTPEF 197
 
Name Accession Description Interval E-value
PAP2_dolichyldiphosphatase cd03382
PAP2_like proteins, dolichyldiphosphatase subfamily. Dolichyldiphosphatase is a ...
 16-180 4.05e-71

PAP2_like proteins, dolichyldiphosphatase subfamily. Dolichyldiphosphatase is a membrane-associated protein located in the endoplasmic reticulum and hydrolyzes dolichyl pyrophosphate, as well as dolichylmonophosphate at a low rate. The enzyme is necessary for maintaining proper levels of dolichol-linked oligosaccharides and protein N-glycosylation, and might play a role in re-utilization of the glycosyl carrier lipid for additional rounds of lipid intermediate biosynthesis after its release during protein N-glycosylation reactions.


Pssm-ID: 239477  Cd Length: 159  Bit Score: 214.45  E-value: 4.05e-71
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30794376  16 VTLTHVEYPAGDLSGHLLAYLSLSPVFVIVGFVTLIIFKRELHTISFLGGLALNEGVNWLIKNVIQEPRPCgGPHTAVGT 95
Cdd:cd03382   1 FSLTHVLYDPGDLLSFLLAYLSLLPVAILVGYATLILFRRELEAIYLFIGLLANEALNYVLKRIIKEPRPC-SGAYFVRS 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30794376  96 KYGMPSSHSQFMWFFSVYSFLFLYLRMHQTNnarflDLLWRHVLSLGLLAVAFLVSYSRVYLLYHTWSQVLYGGIAGGLM 175
Cdd:cd03382  80 GYGMPSSHSQFMGFFAVYLLLFIYLRLGRLN-----SLVSRFLLSLGLLLLALLVSYSRVYLGYHTVSQVVVGAIVGILL 154


                ....*
gi 30794376 176 AIAWF 180
Cdd:cd03382 155 GILWF 159
PAP2_like cd01610
PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, ...
 55-180 4.38e-16

PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid phosphatase, vanadium chloroperoxidases, vanadium bromoperoxidases, and several other mostly uncharacterized subfamilies. Several members of this superfamily have been predicted to be transmembrane proteins.


Pssm-ID: 238813 [Multi-domain]  Cd Length: 122  Bit Score: 71.72  E-value: 4.38e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30794376  55 RELHTISFLGGLALNEGVNWLIKNVIQEPRP--------CGGPHTAVGTKYGMPSSHSQFMWFFSVYSFLFLYLRmhqtn 126
Cdd:cd01610   1 RRLLALLLLLALLAGLLLTGVLKYLFGRPRPyfllrcgpDGDPLLLTEGGYSFPSGHAAFAFALALFLALLLPRR----- 75

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 30794376 127 narfldlLWRHVLSLGLLAVAFLVSYSRVYLLYHTWSQVLYGGIAGGLMAIAWF 180
Cdd:cd01610  76 -------LLRLLLGLLLLLLALLVGLSRVYLGVHYPSDVLAGALLGILVALLVL 122
PAP2 pfam01569
PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), ...
 61-184 6.00e-15

PAP2 superfamily; This family includes the enzyme type 2 phosphatidic acid phosphatase (PAP2), Glucose-6-phosphatase EC:3.1.3.9, Phosphatidylglycerophosphatase B EC:3.1.3.27 and bacterial acid phosphatase EC:3.1.3.2. The family also includes a variety of haloperoxidases that function by oxidising halides in the presence of hydrogen peroxide to form the corresponding hypohalous acids.


Pssm-ID: 426329 [Multi-domain]  Cd Length: 124  Bit Score: 68.99  E-value: 6.00e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30794376    61 SFLGGLALNEGVNWLIKNVIQEPRP-----CGGPHTAVGT----KYGMPSSHSQFMWFFSVYSFLFLylrmhqtnnaRFL 131
Cdd:pfam01569   1 ILLLALALAGLLSSVLKDYFGRPRPfflllEGGLVPAPSTlpglGYSFPSGHSATAFALALLLALLL----------RRL 70

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 30794376   132 DLLWRHVLSLGLLAVAFLVSYSRVYLLYHTWSQVLYGGIAGGLMAIAWFIFTQ 184
Cdd:pfam01569  71 RKIVRVLLALLLLVLALLVGLSRLYLGVHFPSDVLAGALIGILLALLVYRLVP 123
acidPPc smart00014
Acid phosphatase homologues;
65-180 1.51e-12

Acid phosphatase homologues;


Pssm-ID: 214471 [Multi-domain]  Cd Length: 116  Bit Score: 62.36  E-value: 1.51e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30794376     65 GLALNEGVNWLIKNVIQEPRP--------CGGPHTAVGTK--YGMPSSHSQFMWFFSVYSFLFLYLRMHqtnnarfldll 134
Cdd:smart00014   3 LAVVSQLFNGVIKNYFGRPRPfflsigdaCCTPNFLLTLEagYSFPSGHTAFAFAFALFLLLYLPARAG----------- 71

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 30794376    135 wRHVLSLGLLAVAFLVSYSRVYLLYHTWSQVLYGGIAGGLMAIAWF 180
Cdd:smart00014  72 -RKLLIFLLLLLALVVGFSRVYLGAHWPSDVLAGSLLGILIAAVLF 116
PAP2_wunen cd03384
PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid ...
 59-177 7.94e-12

PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the survival of PGCs and is essential in the migration process of these cells towards the somatic gonadal precursors.


Pssm-ID: 239479  Cd Length: 150  Bit Score: 61.11  E-value: 7.94e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30794376  59 TISFLGGLALNEGVNWLIKNVIQEPRP--------------CGGPHTAVGTKYGM--------------PSSHSQFmwff 110
Cdd:cd03384   6 VGVFLFGLFATQLLTDLGKYVTGRLRPhfldvckpnytdltCSLDHQYIADCTCCtgdpdlirearlsfPSGHASL---- 81

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 30794376 111 SVYSFLFLYLRMHQTNNARFLDLLwRHVLSLGLLAVAFLVSYSRVYLLYHTWSQVLYGGIAGGLMAI 177
Cdd:cd03384  82 SMYAAVFLALYLQARLKLRGSRLL-RPLLQFLLLALALYVGLSRISDYKHHWSDVLAGALLGSVIAL 147
PAP2_like_2 cd03392
PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 41-187 5.03e-11

PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239486  Cd Length: 182  Bit Score: 59.54  E-value: 5.03e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30794376  41 VFVIVGFVTLIIFKRELHTISFLGGLALNEGVNWLIKNVIQEPRPCGGPHTAVGTkYGMPSSHSqfMWFFSVYSFLFLYL 120
Cdd:cd03392  46 IIVLLLALLLLLKRRRRAALFLLLALLGGGALNTLLKLLVQRPRPPLHLLVPEGG-YSFPSGHA--MGATVLYGFLAYLL 122

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 30794376 121 RMHQTNNArfldllWRHVLSLGLLAVAFLVSYSRVYLLYHTWSQVLyggiAGGLMAIAWFIFTQEVL 187
Cdd:cd03392 123 ARRLPRRR------VRILLLILAAILILLVGLSRLYLGVHYPSDVL----AGWLLGLAWLALLILLY 179
PAP2_containing_1_like cd03390
PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. ...
 32-180 7.45e-10

PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. Most likely membrane-associated phosphatidic acid phosphatases. Plant members of this group are constitutively expressed in many tissues and exhibit both diacylglycerol pyrophosphate phosphatase activity as well as phosphatidate (PA) phosphatase activity, they may have a more generic housekeeping role in lipid metabolism.


Pssm-ID: 239484 [Multi-domain]  Cd Length: 193  Bit Score: 56.46  E-value: 7.45e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30794376  32 LLAYLSLSPVFVIvgFVTLIIFKRELH-TISFLGGLALNEGVNWLI----KNVIQEPRP--------------------- 85
Cdd:cd03390  18 LVIISVGIPLLVI--ILISLFFRRSLWdLHTSLLGLLLSVSLNGVItnvlKNYAGRPRPdflarcfpdggtpsdtlvgid 95

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30794376  86 --CGGPHTAV--GTKyGMPSSHSQFMwfFSVYSFLFLYL--RMHQTNNARFLdllWRHVLSLGLLAVAFLVSYSRVYLLY 159
Cdd:cd03390  96 icCTGDPGVLkeGRK-SFPSGHSSFA--FAGLGFLSLYLagKLHIFDPRGSS---WRLLLALLPLLLAILVAVSRTRDYR 169

                       170       180
                ....*....|....*....|.
gi 30794376 160 HTWSQVLYGGIAGGLMAIAWF 180
Cdd:cd03390 170 HHFSDVIAGSLIGLIIAYLSY 190
PAP2_like_4 cd03395
PAP2_like_4 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 73-184 2.24e-07

PAP2_like_4 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239489  Cd Length: 177  Bit Score: 49.18  E-value: 2.24e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30794376  73 NWLIKNVIQEPRPCGGPHTAV-------GTKYGMPSSHSQFMwfFSVYSFLFLylrmhqtnnarfldLLWRHVLSLGLLA 145
Cdd:cd03395  73 SGFLKPLVARLRPCNALDGVRlvvlgdqGGSYSFASSHAANS--FALALFIWL--------------FFRRGLFSPVLLL 136

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 30794376 146 VAFLVSYSRVYLLYHTWSQVLYGGIAGGLMA-IAWFIFTQ 184
Cdd:cd03395 137 WALLVGYSRVYVGVHYPGDVIAGALIGIISGlLFYLLFSW 176
PgpB COG0671
Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; ...
 9-184 4.80e-07

Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]; Membrane-associated phospholipid phosphatase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 440435 [Multi-domain]  Cd Length: 189  Bit Score: 48.50  E-value: 4.80e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30794376   9 LPASWRPVTLTHVEYPAGDLSGHLLAYLSLSPVFVIVGFVTLIIFKRELHTISFLGGLALNEGVNWLIKNVIQEPRPCGG 88
Cdd:COG0671  25 LALLLLLALLLLLLLLLALLLILLLLLLLLLLLLLLLLLLLRLLALLLLLLLLAALLLLLLLLLLLLLKYLFGRPRPFVV 104

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30794376  89 P----HTAVGTKYGMPSSHSqfMWFFSVYSFLFLylrmhqtnnarfldLLWRHVLSLGLLAVAFLVSYSRVYLLYHTWSQ 164
Cdd:COG0671 105 PdlelLLGTAGGYSFPSGHA--AAAFALALVLAL--------------LLPRRWLAALLLALALLVGLSRVYLGVHYPSD 168

                       170       180
                ....*....|....*....|
gi 30794376 165 VLYGGIAGGLMAIAWFIFTQ 184
Cdd:COG0671 169 VLAGALLGLAIALLLLALLR 188
PAP2_like_5 cd03394
PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This ...
 65-176 1.17e-06

PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase.


Pssm-ID: 239488 [Multi-domain]  Cd Length: 106  Bit Score: 45.78  E-value: 1.17e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30794376  65 GLALNEGVNWLIKNVIQEPRPCGGPhtavGTKYGMPSSHSQfmWFFSVYSFLflylrmhqtnnARFLDLLWrhvLSLGLL 144
Cdd:cd03394  11 AAALTAAVTEGLKFAVGRARPDGSN----NGYRSFPSGHTA--SAFAAATFL-----------QYRYGWRW---YGIPAY 70

                        90       100       110
                ....*....|....*....|....*....|..
gi 30794376 145 AVAFLVSYSRVYLLYHTWSQVLYGGIAGGLMA 176
Cdd:cd03394  71 ALASLVGASRVVANRHWLSDVLAGAAIGILVG 102
PAP2_SPPase1 cd03388
PAP2_like proteins, sphingosine-1-phosphatase subfamily. Sphingosine-1-phosphatase is an ...
 66-180 2.00e-04

PAP2_like proteins, sphingosine-1-phosphatase subfamily. Sphingosine-1-phosphatase is an intracellular enzyme located in the endoplasmic reticulum, which regulates the level of sphingosine-1-phosphate (S1P), a bioactive lipid. S1P acts as a second messenger in the cell, and extracellularly by binding to G-protein coupled receptors of the endothelial differentiation gene family.


Pssm-ID: 239482  Cd Length: 151  Bit Score: 40.29  E-value: 2.00e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30794376  66 LALNEGVNWLIKNVIQEPRPCGGP---HTAVGT--KYGMPSSHSqfMWFFSVySFLFLYLRMHqtnnarfldlLWRHVLS 140
Cdd:cd03388  42 LALGMYIGQFIKDLFCLPRPSSPPvvrLTMSSAalEYGFPSTHA--MNATAI-SFYLLIYLYD----------RYQYPFV 108

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 30794376 141 LGLLAVAF---LVSYSRVYLLYHTWSQVLYGGIAGGLMAIAWF 180
Cdd:cd03388 109 LGLILALFystLVCLSRIYMGMHSVLDVIAGSLIGVLILLFRF 151
PLN02525 PLN02525
phosphatidic acid phosphatase family protein
 76-202 3.98e-04

phosphatidic acid phosphatase family protein


Pssm-ID: 215288  Cd Length: 352  Bit Score: 40.88  E-value: 3.98e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30794376   76 IKNVIQEPRPCGGP---HTAVGTK------YGMPSSHSQFMWFFSVYsfLFLYLRMHQTN-NARfldlLWRHVLSLGLLA 145
Cdd:PLN02525  54 IKDVVSAPRPSCPPvrrVTATKDEeenameYGLPSSHTLNTVCLSGY--LLHYVLSYLQNvDAS----VIFAGLALFCLL 127

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 30794376  146 VAfLVSYSRVYLLYHTWSQVlYGGIAGGLMAIA-W---------FIFTQEVLTPLFPRIA-----AWPVSEF 202
Cdd:PLN02525 128 VA-LVGFGRLYLGMHSPIDI-IAGLAIGLVILAfWltvdeyvdaFITSGQNVTPFWAALSflllfAYPTPEF 197
PAP2_diacylglycerolkinase cd03383
PAP2_like proteins, diacylglycerol_kinase like sub-family. In some prokaryotes, PAP2_like ...
 98-183 3.26e-03

PAP2_like proteins, diacylglycerol_kinase like sub-family. In some prokaryotes, PAP2_like phosphatase domains appear fused to E. coli DAGK-like trans-membrane diacylglycerol kinase domains. The cellular function of these architectures remains to be determined.


Pssm-ID: 239478 [Multi-domain]  Cd Length: 109  Bit Score: 36.15  E-value: 3.26e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30794376  98 GMPSSHSQFMwfFSVYSFLFLylrmhQTNNarfldllwrHVLSLGLLAVAFLVSYSRVYLLYHTWSQVLYGGIAGGLmaI 177
Cdd:cd03383  40 GMPSGHAAIA--FSIATAISL-----ITNN---------PIISILSVLLAVMVAHSRVEMKIHTMWEVVVGAILGAL--I 101


                ....*.
gi 30794376 178 AWFIFT 183
Cdd:cd03383 102 TLLIFK 107
PLN02250 PLN02250
lipid phosphate phosphatase
 100-184 9.91e-03

lipid phosphate phosphatase


Pssm-ID: 215139  Cd Length: 314  Bit Score: 36.44  E-value: 9.91e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30794376  100 PSSHSQfmWFFSVYSFLFLYLrmhqTNNARFLDLLwRHVLSLGL----LAVAFLVSYSRVYLLYHTWSQVLYGGIAGglM 175
Cdd:PLN02250 164 PSGHTS--WSFAGLGFLSLYL----SGKIRVFDRR-GHVAKLCIvflpLLVAALVGVSRVDDYWHHWQDVFAGALIG--L 234


                 ....*....
gi 30794376  176 AIAWFIFTQ 184
Cdd:PLN02250 235 TVASFCYLQ 243
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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