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Conserved domains on  [gi|31083344|ref|NP_064707|]
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atypical chemokine receptor 3 [Homo sapiens]

Protein Classification

G protein-coupled receptor family protein; olfactory receptor( domain architecture ID 11606590)

G protein-coupled receptor family protein is a seven-transmembrane G protein-coupled receptor (7TM-GPCR) family protein which typically transmits an extracellular signal into the cell by the conformational rearrangement of the 7TM helices and by the subsequent binding and activation of an intracellular heterotrimeric G protein; GPCR ligands include light-sensitive compounds, odors, pheromones, hormones, and neurotransmitters; olfactory receptor plays a central role in olfaction or the sense of smell, similar to human family 6 olfactory receptors; belongs to the class A rhodopsin-like family of G protein-coupled receptors; binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf)

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
7tmA_ACKR3_CXCR7 cd14987
CXC chemokine receptor 7, member of the class A family of seven-transmembrane G ...
45-326 0e+00

CXC chemokine receptor 7, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR3, also known as CXCR7, is an atypical chemokine receptor for CXCL12 and CXCR11. Unlike the classical chemokine receptors, ACKR3 contains a DRYLSIT-sequence instead of the conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. Thus, ACKR3 does not activate classical GPCR signaling, instead induces beta-arrestin recruitment which is leading to ligand internalization and MAP-kinase activation. It is acting as a scavenger for CXCL12 and, to a lesser degree, for CXCL11. ACKR3 is highly expressed by blood vascular endothelial cells in brain, in numerous embryonic and neonatal tissues, in inflamed tissues and in a variety of cancers such as lymphomas, sarcomas, prostate and breast cancers, and gliomas. Five receptors have been identified for the ACKR family, including CC-Chemokine Receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, DARC, and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


:

Pssm-ID: 320118 [Multi-domain]  Cd Length: 282  Bit Score: 507.37  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  45 YTLSFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVTHLIF 124
Cdd:cd14987   1 YTLSFFYIFIFVIGLLANSVVVWVNLQAKRTGYETHLYILNLAIADLCVVATLPVWVVSLVQHNQWPMGEFTCKITHLIF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 125 SINLFGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDTYYLKTVTSASNNETYCRSFYPEHS 204
Cdd:cd14987  81 SINLFGSIFFLTCMSVDRYLSVTLFGNTSSRRKKIVRRIICVLVWLLAFVASLPDTYFLKTVTSPSNNETYCRSFYPEES 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 205 IKEWLIGMELVSVVLGFAVPFSIIAVFYFLLARAISASSDQEKHSSRKIIFSYVVVFLVCWLPYHVAVLLDIFSILHYIP 284
Cdd:cd14987 161 FKEWLIGMELVSIVLGFVIPFPIIAVFYFLLARAISASSDQERKSSRKIIFSYVVVFLVCWLPYHTVVLLDILSFLHLIP 240
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 31083344 285 FTCRLEHALFTALHVTQCLSLVHCCVNPVLYSFINRNYRYEL 326
Cdd:cd14987 241 FSCQLENFLYAALHVTQCFSLVHCCVNPILYSFINRNYRYEL 282
 
Name Accession Description Interval E-value
7tmA_ACKR3_CXCR7 cd14987
CXC chemokine receptor 7, member of the class A family of seven-transmembrane G ...
45-326 0e+00

CXC chemokine receptor 7, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR3, also known as CXCR7, is an atypical chemokine receptor for CXCL12 and CXCR11. Unlike the classical chemokine receptors, ACKR3 contains a DRYLSIT-sequence instead of the conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. Thus, ACKR3 does not activate classical GPCR signaling, instead induces beta-arrestin recruitment which is leading to ligand internalization and MAP-kinase activation. It is acting as a scavenger for CXCL12 and, to a lesser degree, for CXCL11. ACKR3 is highly expressed by blood vascular endothelial cells in brain, in numerous embryonic and neonatal tissues, in inflamed tissues and in a variety of cancers such as lymphomas, sarcomas, prostate and breast cancers, and gliomas. Five receptors have been identified for the ACKR family, including CC-Chemokine Receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, DARC, and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320118 [Multi-domain]  Cd Length: 282  Bit Score: 507.37  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  45 YTLSFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVTHLIF 124
Cdd:cd14987   1 YTLSFFYIFIFVIGLLANSVVVWVNLQAKRTGYETHLYILNLAIADLCVVATLPVWVVSLVQHNQWPMGEFTCKITHLIF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 125 SINLFGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDTYYLKTVTSASNNETYCRSFYPEHS 204
Cdd:cd14987  81 SINLFGSIFFLTCMSVDRYLSVTLFGNTSSRRKKIVRRIICVLVWLLAFVASLPDTYFLKTVTSPSNNETYCRSFYPEES 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 205 IKEWLIGMELVSVVLGFAVPFSIIAVFYFLLARAISASSDQEKHSSRKIIFSYVVVFLVCWLPYHVAVLLDIFSILHYIP 284
Cdd:cd14987 161 FKEWLIGMELVSIVLGFVIPFPIIAVFYFLLARAISASSDQERKSSRKIIFSYVVVFLVCWLPYHTVVLLDILSFLHLIP 240
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 31083344 285 FTCRLEHALFTALHVTQCLSLVHCCVNPVLYSFINRNYRYEL 326
Cdd:cd14987 241 FSCQLENFLYAALHVTQCFSLVHCCVNPILYSFINRNYRYEL 282
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
62-315 8.80e-65

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 206.38  E-value: 8.80e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344    62 NSVVVWVNIQAKTTGYDTHCYILNLAIADLWV-VLTIPVWVVSLVQHNQWPMGELTCKVTHLIFSINLFGSIFFLTCMSV 140
Cdd:pfam00001   2 NLLVILVILRNKKLRTPTNIFLLNLAVADLLFsLLTLPFWLVYYLNHGDWPFGSALCKIVGALFVVNGYASILLLTAISI 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344   141 DRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDTYYLKTVTSASNNETYCRSFYPEHSIKEWLIGmeLVSVVLG 220
Cdd:pfam00001  82 DRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPPLLFGWTLTVPEGNVTVCFIDFPEDLSKPVSYT--LLISVLG 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344   221 FAVPFSIIAVFYFLLARAISASSDQEKHSSR--------KIIFSYVVVFLVCWLPYHVAVLLDIFSIlhyipfTCRLEHA 292
Cdd:pfam00001 160 FLLPLLVILVCYTLIIRTLRKSASKQKSSERtqrrrkalKTLAVVVVVFILCWLPYHIVNLLDSLAL------DCELSRL 233
                         250       260
                  ....*....|....*....|...
gi 31083344   293 LFTALHVTQCLSLVHCCVNPVLY 315
Cdd:pfam00001 234 LDKALSVTLWLAYVNSCLNPIIY 256
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
46-339 7.51e-39

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 141.07  E-value: 7.51e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344   46 TLSFIYIFIFVIGMIANSVVVWVNIQAKTTGYdTHCYILNLAIADLWVVLTIPVWVVSlVQHNQWPMGELTCKVTHLIFS 125
Cdd:PHA03087  42 ILIVVYSTIFFFGLVGNIIVIYVLTKTKIKTP-MDIYLLNLAVSDLLFVMTLPFQIYY-YILFQWSFGEFACKIVSGLYY 119
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  126 INLFGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPdtYYLKTVTSASNNETYCRSFYPEHSi 205
Cdd:PHA03087 120 IGFYNSMNFITVMSVDRYIAIVHPVKSNKINTVKYGYIVSLVIWIISIIETTP--ILFVYTTKKDHETLICCMFYNNKT- 196
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  206 KEWLIGMELVSVVLGFAVPFSIIAVFYF-LLARAISASSDQEKHSSRKIIFSYVVVFLVCWLPYHVAVLLDIFSILHYIP 284
Cdd:PHA03087 197 MNWKLFINFEINIIGMLIPLTILLYCYSkILITLKGINKSKKNKKAIKLVLIIVILFVIFWLPFNVSVFVYSLHILHFKS 276
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 31083344  285 fTCRLEHALFTALHVTQCLSLVHCCVNPVLYSFINRNYRYELMKAFIFKYSAKTG 339
Cdd:PHA03087 277 -GCKAVKYIQYALHVTEIISLSHCCINPLIYAFVSEFFNKHKKKSLKLMFTSSGK 330
 
Name Accession Description Interval E-value
7tmA_ACKR3_CXCR7 cd14987
CXC chemokine receptor 7, member of the class A family of seven-transmembrane G ...
45-326 0e+00

CXC chemokine receptor 7, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR3, also known as CXCR7, is an atypical chemokine receptor for CXCL12 and CXCR11. Unlike the classical chemokine receptors, ACKR3 contains a DRYLSIT-sequence instead of the conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. Thus, ACKR3 does not activate classical GPCR signaling, instead induces beta-arrestin recruitment which is leading to ligand internalization and MAP-kinase activation. It is acting as a scavenger for CXCL12 and, to a lesser degree, for CXCL11. ACKR3 is highly expressed by blood vascular endothelial cells in brain, in numerous embryonic and neonatal tissues, in inflamed tissues and in a variety of cancers such as lymphomas, sarcomas, prostate and breast cancers, and gliomas. Five receptors have been identified for the ACKR family, including CC-Chemokine Receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, DARC, and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320118 [Multi-domain]  Cd Length: 282  Bit Score: 507.37  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  45 YTLSFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVTHLIF 124
Cdd:cd14987   1 YTLSFFYIFIFVIGLLANSVVVWVNLQAKRTGYETHLYILNLAIADLCVVATLPVWVVSLVQHNQWPMGEFTCKITHLIF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 125 SINLFGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDTYYLKTVTSASNNETYCRSFYPEHS 204
Cdd:cd14987  81 SINLFGSIFFLTCMSVDRYLSVTLFGNTSSRRKKIVRRIICVLVWLLAFVASLPDTYFLKTVTSPSNNETYCRSFYPEES 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 205 IKEWLIGMELVSVVLGFAVPFSIIAVFYFLLARAISASSDQEKHSSRKIIFSYVVVFLVCWLPYHVAVLLDIFSILHYIP 284
Cdd:cd14987 161 FKEWLIGMELVSIVLGFVIPFPIIAVFYFLLARAISASSDQERKSSRKIIFSYVVVFLVCWLPYHTVVLLDILSFLHLIP 240
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 31083344 285 FTCRLEHALFTALHVTQCLSLVHCCVNPVLYSFINRNYRYEL 326
Cdd:cd14987 241 FSCQLENFLYAALHVTQCFSLVHCCVNPILYSFINRNYRYEL 282
7tmA_Chemokine_R cd14984
classical and atypical chemokine receptors, member of the class A family of ...
47-326 1.33e-76

classical and atypical chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. In addition to these classical chemokine receptors, there exists a subfamily of atypical chemokine receptors (ACKRs) that are unable to couple to G-proteins and, instead, they preferentially mediate beta-arrestin dependent processes, such as receptor internalization, after ligand binding. The classical chemokine receptors contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. However, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 341319 [Multi-domain]  Cd Length: 278  Bit Score: 237.11  E-value: 1.33e-76
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  47 LSFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVQHnqWPMGELTCKVTHLIFSI 126
Cdd:cd14984   3 LPVLYSLVFLLGLVGNSLVLLVLLYYRKLRSMTDVYLLNLALADLLFVLTLPFWAVYAADG--WVFGSFLCKLVSALYTI 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 127 NLFGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDTYYLKTVTSasNNETYCRSFYPEHSIK 206
Cdd:cd14984  81 NFYSGILFLACISIDRYLAIVHAVSALRARTLLHGKLTCLGVWALALLLSLPEFIFSQVSEE--NGSSICSYDYPEDTAT 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 207 EWLIGMELVSVVLGFAVPFSIIAVFYFLLARAISASSDQEKHSSRKIIFSYVVVFLVCWLPYHVAVLLDIFSILHYIPFT 286
Cdd:cd14984 159 TWKTLLRLLQNILGFLLPLLVMLFCYSRIIRTLLRARNHKKHRALRVIFAVVVVFFLCWLPYNIVLLLDTLQLLGIISRS 238
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 31083344 287 CRLEHALFTALHVTQCLSLVHCCVNPVLYSFINRNYRYEL 326
Cdd:cd14984 239 CELSKSLDYALQVTESLAFSHCCLNPVLYAFVGVKFRKYL 278
7tmA_CXCR1_2 cd15178
CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G ...
45-326 9.84e-68

CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR1 and CXCR2 are closely related chemotactic receptors for a group of CXC chemokines distinguished by the presence of the amino acid motif ELR immediately adjacent to their CXC motif. Expression of CXCR1 and CXCR2 is strictly controlled in neutrophils by external stimuli such as lipopolysaccharide (LPS), tumor necrosis factor (TNF)-alpha, Toll-like receptor agonists, and nitric oxide. CXCL8 (formerly known as interleukin-8) binds with high-affinity and activates both receptors. CXCR1 also binds CXCL7 (neutrophil-activating protein-2), whereas CXCR2 non-selectively binds to all seven ELR-positive chemokines (CXCL1-7). Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341333 [Multi-domain]  Cd Length: 279  Bit Score: 214.45  E-value: 9.84e-68
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  45 YTLSFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSlvQHNQWPMGELTCKVTHLIF 124
Cdd:cd15178   1 LALCVIYVLVFLLSLPGNSLVVLVILYNRRSRSSTDVYLLHLAIADLLFALTLPFWAVS--VVKGWIFGTFMCKLVSLLQ 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 125 SINLFGSIFFLTCMSVDRYLSITYFTNTPSSrKKMVRRVVCILVWLLAFCVSLPDTYYLKTVTSASNNETYCRSFYPEHS 204
Cdd:cd15178  79 EANFYSGILLLACISVDRYLAIVHATRALTQ-KRHLVKFVCAGVWLLSLLLSLPALLNRDAFKPPNSGRTVCYENLGNES 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 205 IKEWLIGMELVSVVLGFAVPFSIIAVFY-FLLARAISASSDQeKHSSRKIIFSYVVVFLVCWLPYHVAVLLDIFSILHYI 283
Cdd:cd15178 158 ADKWRVVLRILRHTLGFLLPLVVMLFCYgFTIKTLLQTRSFQ-KHRAMRVIFAVVLAFLLCWLPYNVTVLIDTLMRTKLI 236
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 31083344 284 PFTCRLEHALFTALHVTQCLSLVHCCVNPVLYSFINRNYRYEL 326
Cdd:cd15178 237 TETCELRNHVDVALYVTQILGFLHSCINPVLYAFIGQKFRNNL 279
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
62-315 8.80e-65

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 206.38  E-value: 8.80e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344    62 NSVVVWVNIQAKTTGYDTHCYILNLAIADLWV-VLTIPVWVVSLVQHNQWPMGELTCKVTHLIFSINLFGSIFFLTCMSV 140
Cdd:pfam00001   2 NLLVILVILRNKKLRTPTNIFLLNLAVADLLFsLLTLPFWLVYYLNHGDWPFGSALCKIVGALFVVNGYASILLLTAISI 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344   141 DRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDTYYLKTVTSASNNETYCRSFYPEHSIKEWLIGmeLVSVVLG 220
Cdd:pfam00001  82 DRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPPLLFGWTLTVPEGNVTVCFIDFPEDLSKPVSYT--LLISVLG 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344   221 FAVPFSIIAVFYFLLARAISASSDQEKHSSR--------KIIFSYVVVFLVCWLPYHVAVLLDIFSIlhyipfTCRLEHA 292
Cdd:pfam00001 160 FLLPLLVILVCYTLIIRTLRKSASKQKSSERtqrrrkalKTLAVVVVVFILCWLPYHIVNLLDSLAL------DCELSRL 233
                         250       260
                  ....*....|....*....|...
gi 31083344   293 LFTALHVTQCLSLVHCCVNPVLY 315
Cdd:pfam00001 234 LDKALSVTLWLAYVNSCLNPIIY 256
7tmA_GPR182 cd14988
G protein-coupled receptor 182, member of the class A family of seven-transmembrane G ...
47-326 1.29e-64

G protein-coupled receptor 182, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR182 is an orphan G-protein coupled receptor that belongs to the class A of seven-transmembrane GPCR superfamily. When GPR182 gene was first cloned, it was proposed to encode an adrenomedullin receptor. However when the corresponding protein was expressed, it was found not to respond to adrenomedullin (ADM). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320119 [Multi-domain]  Cd Length: 278  Bit Score: 206.55  E-value: 1.29e-64
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  47 LSFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVTHLIFSI 126
Cdd:cd14988   3 LFILYLVIFVVGLVENVLVIWVNWHRWGSKNLVNLYILNMAIADLGVVLTLPVWMLEVMLDYTWLWGSFLCKFTHYFYFA 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 127 NLFGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDTYYLKTVTSAsnnETYCRSFYPEHSIK 206
Cdd:cd14988  83 NMYSSIFFLTCLSVDRYLTLTSSSPFWQQHQHRIRRALCAGIWVLSAIIPLPEVVHMQLLDGV---EPMCLFLAPFETYD 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 207 EWLIGMELVSVVLGFAVPFSIIAVFYFLLARAISASSDQEKHSSRKIIFSYVVVFLVCWLPYHVAVLLDIFSILHYIpFT 286
Cdd:cd14988 160 EWALAVSLLTLIIGFLIPFSIIAVFNVLTARYIRTAGRPESRRHCLLIYAYILVFVVCWLPYHVTLLLLTLHGSHIS-LH 238
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 31083344 287 CRLEHALFTALHVTQCLSLVHCCVNPVLYSFINRNYRYEL 326
Cdd:cd14988 239 CNLVHFLYFFYDVIDCFSLLHCVANPILYNFLSKSFRGKL 278
7tmA_CXCR3 cd15180
CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G ...
47-323 3.01e-59

CXC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR3 is an inflammatory chemotactic receptor for a group of CXC chemokines distinguished by the presence of the amino acid motif ELR immediately adjacent to their CXC motif. CXCR3 specifically binds three chemokines CXCL9 (monokine induced by gamma-interferon), CXCL10 (interferon induced protein of 10 kDa), and CXCL11 (interferon inducible T-cell alpha-chemoattractant, I-TAC). CXC3R is expressed on CD4+ Th1 and CD8+ cytotoxic T lymphocytes as well as highly on innate lymphocytes, such as NK cells and NK T cells, where it may mediate the recruitment of these cells to the sites of infection and inflammation. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341335 [Multi-domain]  Cd Length: 280  Bit Score: 192.60  E-value: 3.01e-59
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  47 LSFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVQhnQWPMGELTCKVTHLIFSI 126
Cdd:cd15180   3 LPVLYSLVFLLGLLGNGLVLAVLLQKRRNLSVTDTFILHLALADILLLVTLPFWAVQAVH--GWIFGTGLCKLAGAVFKI 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 127 NLFGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDTYYLKTVTSASNNETYCRSFYPeHSIK 206
Cdd:cd15180  81 NFYCGIFLLACISFDRYLSIVHAVQMYSRKKPMLVHLSCLIVWLFCLLLSIPDFIFLEATKDPRQNKTECVHNFP-QSDT 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 207 EWLIGMELVSVVLGFAVPFSIIAVFYFLLARAISASSDQ-EKHSSRKIIFSYVVVFLVCWLPYHVAVLLDIFSILHYIPF 285
Cdd:cd15180 160 YWWLALRLLYHIVGFLLPLAVMVYCYTSILLRLLRSSQGfQKQRAIRVIVAVVVVFFLCWTPYNIALLVDTLIDLSVLDR 239
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 31083344 286 TCRLEHALFTALHVTQCLSLVHCCVNPVLYSFINRNYR 323
Cdd:cd15180 240 NCGTESRLDIALSVTSSLGYFHCCLNPLLYAFVGVKFR 277
7tmA_CXCR4 cd15179
CXC chemokine receptor type 4, member of the class A family of seven-transmembrane G ...
47-323 6.81e-58

CXC chemokine receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR4 is the only known G protein-coupled chemokine receptor for the key homeostatic ligand CXCL12, which is constitutively secreted by bone marrow stromal cells. Atypical chemokine receptor CXCR7 (ACKR3) also binds CXCL12, but activates signaling in a G protein-independent manner. CXCR4 is also a co-receptor for HIV infection and plays critical roles in the development of immune system during both lymphopoiesis and myelopoiesis. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341334 [Multi-domain]  Cd Length: 278  Bit Score: 189.21  E-value: 6.81e-58
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  47 LSFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVQhnQWPMGELTCKVTHLIFSI 126
Cdd:cd15179   3 LPTVYSIIFLLGIVGNGLVILVMGYQKKSRTMTDKYRLHLSVADLLFVLTLPFWAVDAAA--NWYFGNFLCKAVHVIYTV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 127 NLFGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDTYYLKTvtSASNNETYCRSFYPEHSIK 206
Cdd:cd15179  81 NLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWLPALLLTVPDLVFAKV--SELDDRYICDRIYPEDTFE 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 207 EWLIGMELVSVVLGFAVPFSIIAVFYFLLARAISASSDQEKHSSRKIIFSYVVVFLVCWLPYHVAVLLDIFSILHYIPFT 286
Cdd:cd15179 159 LWVVAFRFQHILVGLVLPGLVILTCYCIIISKLSHSKGHQKRKALKTTVILILAFFACWLPYYIGISIDTFMLLEIIKQS 238
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 31083344 287 CRLEHALFTALHVTQCLSLVHCCVNPVLYSFINRNYR 323
Cdd:cd15179 239 CEMEQTVHKWISITEALAFFHCCLNPILYAFLGAKFK 275
7tmA_AT1R cd15192
type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G ...
50-323 8.60e-58

type 1 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2R, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Moreover, AT1R promotes cell proliferation, whereas AT2R inhibits proliferation and stimulates cell differentiation. The AT2R is highly expressed during fetal development, however it is scarcely present in adult tissues and is induced in pathological conditions. Generally, the AT1R mediates many actions of Ang II, while the AT2R is involved in the regulation of blood pressure and renal function.


Pssm-ID: 320320 [Multi-domain]  Cd Length: 285  Bit Score: 189.18  E-value: 8.60e-58
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  50 IYIFIFVIGMIANSVVVWV---NIQAKTTGydtHCYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVTHLIFSI 126
Cdd:cd15192   6 VYSIIFVVGIFGNSLVVIViycYMKLKTVA---NIFLLNLALADLCFLITLPLWAAYTAMEYHWPFGNFLCKIASALVSF 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 127 NLFGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDTYYLKTVTSASNNETYCRSFYPEHSiK 206
Cdd:cd15192  83 NLYASVFLLTCLSIDRYLAIVHPMKSRLRRTLVVARVTCIVIWLLAGVASLPAIIHRDVFFIENTNITVCAFHYPSQN-S 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 207 EWLIGMELVSVVLGFAVPFSIIAVFYFLLARAISASSDQEKHSSR-----KIIFSYVVVFLVCWLPYHVAVLLDIFSILH 281
Cdd:cd15192 162 TLLVGLGLMKNLLGFLIPFLIILTCYTLIGKALKKAYEIQRNKPRndeifKMIMAVVLFFFFCWIPHQIFTFLDVLIQLK 241
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 31083344 282 YIPfTCRLEHALFTALHVTQCLSLVHCCVNPVLYSFINRNYR 323
Cdd:cd15192 242 VIQ-DCHIADIVDTAMPFTICIAYFNSCLNPILYGFVGKNFR 282
7tmA_Angiotensin_R-like cd14985
angiotesin receptor family and its related G protein-coupled receptors, member of the class A ...
50-323 2.23e-56

angiotesin receptor family and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the angiotensin receptors, the bradykinin receptors, apelin receptor as well as putative G-protein coupled receptors (GPR15 and GPR25). Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2 receptor, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Bradykinins (BK) are pro-inflammatory peptides that mediate various vascular and pain responses to tissue injury through its B1 and B2 receptors. Apelin (APJ) receptor binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body, and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake. Orphan receptors, GPR15 and GPR25, share strong sequence homology to the angiotensin II type AT1 and AT2 receptors.


Pssm-ID: 341320 [Multi-domain]  Cd Length: 284  Bit Score: 185.66  E-value: 2.23e-56
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  50 IYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVTHLIFSINLF 129
Cdd:cd14985   6 LYIAIFLVGLLGNLFVVWVFLFPRGPKRVADIFIANLAAADLVFVLTLPLWATYTANQYDWPFGAFLCKVSSYVISVNMF 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 130 GSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPdTYYLKTVTSASN-NETYCrsfYPEHSIKEW 208
Cdd:cd14985  86 ASIFLLTCMSVDRYLAIVHPVASRRLRRRRQARVTCALIWVVACLLSLP-TFLLRSLQAIENlNKTAC---IMLYPHEAW 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 209 LIGMELVSVVLGFAVPFSIIAVFYFLLARAISASSDQEKHSSR------KIIFSYVVVFLVCWLPYHVAVLLDI-FSILH 281
Cdd:cd14985 162 HFGLSLELNILGFVLPLLIILTCYFHIARSLRKRYERTGKNGRkrrkslKIIFALVVAFLVCWLPFHFFKFLDFlAQLGA 241
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 31083344 282 YIPftCRLEHALFTALHVTQCLSLVHCCVNPVLYSFINRNYR 323
Cdd:cd14985 242 IRP--CFWELFLDLGLPIATCLAFTNSCLNPFIYVFVDRRFR 281
7tmA_purinoceptor-like cd14982
purinoceptor and its related proteins, member of the class A family of seven-transmembrane G ...
51-326 3.74e-54

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this subfamily include lysophosphatidic acid receptor, P2 purinoceptor, protease-activated receptor, platelet-activating factor receptor, Epstein-Barr virus induced gene 2, proton-sensing G protein-coupled receptors, GPR35, and GPR55, among others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341318 [Multi-domain]  Cd Length: 283  Bit Score: 179.77  E-value: 3.74e-54
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  51 YIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVTHLIFSINLFG 130
Cdd:cd14982   7 YSLIFILGLLGNILALWVFLRKMKKRSPTTIYMINLALADLLFVLTLPFRIYYYLNGGWWPFGDFLCRLTGLLFYINMYG 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 131 SIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDTYYLKTVTSASNNETyCRSFYPEHsiKEWLI 210
Cdd:cd14982  87 SILFLTCISVDRYLAVVHPLKSRRLRRKRYAVGVCAGVWILVLVASVPLLLLRSTIAKENNSTT-CFEFLSEW--LASAA 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 211 GMELVSVVLGFAVPFSIIAVFYFLLARAISASSDQEKHSSRK-----IIFSYVVVFLVCWLPYHVAVLLDIFSILHYIpF 285
Cdd:cd14982 164 PIVLIALVVGFLIPLLIILVCYSLIIRALRRRSKQSQKSVRKrkalrMILIVLAVFLVCFLPYHVTRILYLLVRLSFI-A 242
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 31083344 286 TCRLEHALFTALHVTQCLSLVHCCVNPVLYSFINRNYRYEL 326
Cdd:cd14982 243 DCSARNSLYKAYRITLCLASLNSCLDPLIYYFLSKTFRKRL 283
7tmA_Apelin_R cd15190
apelin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
50-323 4.28e-54

apelin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Apelin (APJ) receptor is a G protein-coupled receptor that binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake.


Pssm-ID: 341340 [Multi-domain]  Cd Length: 304  Bit Score: 180.34  E-value: 4.28e-54
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  50 IYIFIFVIGMIANSVVVWVNIQAKTTGY-DTHCYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVTHLIFSINL 128
Cdd:cd15190  16 IYMLVFVLGLSGNGLVLWTVFRSKRKRRrSADTFIANLALADLTFVVTLPLWAVYTALGYHWPFGSFLCKLSSYLVFVNM 95
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 129 FGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDTYYLKTVTSASNNETYCRSFYPEHSIKE- 207
Cdd:cd15190  96 YASVFCLTGLSFDRYLAIVRSLASAKLRSRTSGIVALGVIWLLAALLALPALILRTTSDLEGTNKVICDMDYSGVVSNEs 175
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 208 ---WLIGMELVSVVLGFAVPFSIIAVFYFLLARAIS-------ASSDQEKHSSRKIIFSYVVVFLVCWLPYHVAVLLDIF 277
Cdd:cd15190 176 ewaWIAGLGLSSTVLGFLLPFLIMLTCYFFIGRTVArhfsklrRKEDKKKRRLLKIIITLVVTFALCWLPFHLVKTLYAL 255
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 31083344 278 SILHYIPFTCRLEHALFTALHVTQCLSLVHCCVNPVLYSFINRNYR 323
Cdd:cd15190 256 MYLGILPFSCGFDLFLMNAHPYATCLAYVNSCLNPFLYAFFDPRFR 301
7tmA_ACKR4_CCR11 cd15176
atypical chemokine receptor 4, member of the class A family of seven-transmembrane G ...
47-323 5.05e-53

atypical chemokine receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR4 was first reported to bind several CC chemokines including CCL19, CCL21, and CCL25 and was originally designated CCR11. AKCR4 is unable to couple to G-protein and, instead, it preferentially mediates beta-arrestin dependent processes, such as receptor internalization, after ligand binding. Thus, ACKR4 may act as a scavenger receptor to suppress the effects of proinflammatory chemokines. Unlike the classical chemokine receptors that contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320304 [Multi-domain]  Cd Length: 276  Bit Score: 176.47  E-value: 5.05e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  47 LSFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVqhNQWPMGELTCKVTHLIFSI 126
Cdd:cd15176   3 LPVFYTIALVVGLAGNSLVVAIYAYYKKLKTKTDVYILNLAVADLLLLFTLPFWAADAV--NGWVLGTAMCKITSALYTM 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 127 NLFGSIFFLTCMSVDRYLSITYFTNTPSSRKKmvRRVVCILVWLLAFCVSLPDTYYlKTVTSASNNETyCRSFYPEHSIK 206
Cdd:cd15176  81 NFSCGMQFLACISVDRYVAITKATSRQFTGKH--CWIVCLCVWLLAILLSIPDLVF-STVRENSDRYR-CLPVFPPSLVT 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 207 EWLIGMELVSVVLGFAVPFSIIAVFYFLLARAISASSDQEKHSSRKIIFSYVVVFLVCWLPYHVAVLLDIFSILHYIPFT 286
Cdd:cd15176 157 SAKATIQILEVLLGFVLPFLVMVFCYSRVARALSRTPNVKKSRALKVLLAVVGVFIVTQLPYNVVKFYRAIDVIYLLITD 236
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 31083344 287 CRLEHALFTALHVTQCLSLVHCCVNPVLYSFINRNYR 323
Cdd:cd15176 237 CSMSKTLDIAIQVTESIALFHSCLNPVLYVFMGASFK 273
7tmA_AT2R cd15191
type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G ...
50-326 2.41e-52

type 2 angiotensin II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2R, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Moreover, AT1R promotes cell proliferation, whereas AT2R inhibits proliferation and stimulates cell differentiation. The AT2R is highly expressed during fetal development, however it is scarcely present in adult tissues and is induced in pathological conditions. Generally, the AT1R mediates many actions of Ang II, while the AT2R is involved in the regulation of blood pressure and renal function.


Pssm-ID: 341341 [Multi-domain]  Cd Length: 285  Bit Score: 174.94  E-value: 2.41e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  50 IYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVTHLIFSINLF 129
Cdd:cd15191   6 LYSIIFILGFLGNSLVVCVFCHQSGPKTVASIYIFNLAVADLLFLATLPLWATYYSYGYNWLFGSVMCKICGSLLTLNLF 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 130 GSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRrVVCILVWLLAFCVSLPDTYYLKTVTSASNNETYCRSFYPEHSIKEWL 209
Cdd:cd15191  86 ASIFFITCMSVDRYLAVVYPLRSQRRRSWQAR-LVCLLVWVLACLSSLPTFYFRDTYYIEELGVNACIMAFPNEKYAQWS 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 210 IGMELVSVVLGFAVPFSIIAVFYFLLARAISASSDQEKHSSR-----KIIFSYVVVFLVCWLPYHVAVLLDIFSILHYIP 284
Cdd:cd15191 165 AGLALMKNTLGFLIPLIVIATCYFGIGRHLLKTKGFGKNKQRrdkvlKMVAAVVLAFLICWFPFHVLTFLDALARMGVIN 244
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 31083344 285 fTCRLEHALFTALHVTQCLSLVHCCVNPVLYSFINRNYRYEL 326
Cdd:cd15191 245 -NCWVITVIDKALPFAICLGFSNSCINPFLYCFVGNHFREKL 285
7tmA_CCR10 cd15177
CC chemokine receptor type 10, member of the class A family of seven-transmembrane G ...
50-326 2.13e-49

CC chemokine receptor type 10, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR10 is a homeostatic receptor specific for two C-C motif chemokines, CCL27 and CCL28. Activation of CCR10 by its two ligands mediates diverse activities, ranging from leukocyte trafficking to skin cancer. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341332 [Multi-domain]  Cd Length: 280  Bit Score: 167.26  E-value: 2.13e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  50 IYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVQhnQWPMGELTCKVTHLIFSINLF 129
Cdd:cd15177   6 VYLVVFVLGLVGNGLVLATHTRYRRLRSMTDVYLLNLALADLLLLLTLPFAAAETLQ--GWIFGNAMCKLIQGLYAINFY 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 130 GSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRR--VVCILVWLLAFCVSLPDTYYLKTvtSASNNETYCRSFYPEHSIKE 207
Cdd:cd15177  84 SGFLFLTCISVDRYVVIVRATSAHRLRPKTLFYsvLTSLIVWLLSILFALPQLIYSRV--ENRSELSSCRMIFPEVVSRT 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 208 WLIGMELVSVVLGFAVPFSIIAVFYFLLARAISASSDQEKHSSRKIIFSYVVVFLVCWLPYHVAVLLDIFSILHYIPFTC 287
Cdd:cd15177 162 VKGATALTQVVLGFAIPLIVMAVCYAAIGRTLLAARGWERHRALRVIAALVVAFVLFQLPYSVVLLLDTADLLATLELSC 241
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 31083344 288 RLEHALFTALHVTQCLSLVHCCVNPVLYSFINRNYRYEL 326
Cdd:cd15177 242 SQSKRKDIALLVTSGLAYVRCCLNPLLYAFVGVRFRRDI 280
7tmA_Proton-sensing_R cd15160
proton-sensing G protein-coupled receptors, member of the class A family of ...
45-326 3.14e-49

proton-sensing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Proton/pH-sensing G-protein coupled receptors sense pH of 7.6 to 6.0. They mediate a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. The proton/pH-sensing receptor family includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 (TDAG8, GPR65) receptor, ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4).


Pssm-ID: 320288 [Multi-domain]  Cd Length: 280  Bit Score: 166.79  E-value: 3.14e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  45 YTLSFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVTHLIF 124
Cdd:cd15160   1 IFLPVVYSFVFVVGLPANCLALWVLYLQIKKENVLGVYLLNLSLSDLLYILTLPLWIDYTANHHNWTFGPLSCKVVGFFF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 125 SINLFGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDTYYLKTVTSaSNNETYCRSFYPehs 204
Cdd:cd15160  81 YTNIYASIGFLCCIAVDRYLAVVHPLRFRGLRTRRFALKVSASIWVLELGTHSVFLGHDELFRD-EPNHTLCYEKYP--- 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 205 IKEWLIGMELVSVVLGFAVPFSIIAVFYFLLARAISASSDQEKHSSRKII---FSYVVVFLVCWLPYHVaVLLDIFSILH 281
Cdd:cd15160 157 MEGWQASYNYARFLVGFLIPLSLILFFYRRVLRAVRQSPSLEREEKRKIIgllLSIVVIFLLCFLPYHV-VLLVRSVIEL 235
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 31083344 282 YIPFTCRLEHALFTALHVTQCLSLVHCCVNPVLYSFINRNYRYEL 326
Cdd:cd15160 236 VQNGLCGFEKRVFTAYQISLCLTSLNCVADPILYIFVTEDVRQDL 280
7tmA_GPR25 cd15193
G protein-coupled receptor 25, member of the class A family of seven-transmembrane G ...
47-323 6.72e-49

G protein-coupled receptor 25, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR25 is an orphan G-protein coupled receptor that shares strong sequence homology to GPR15 and the angiotensin II receptors. These closely related receptors form a group within the class A G-protein coupled receptors (GPCRs). GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation. Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors.


Pssm-ID: 320321 [Multi-domain]  Cd Length: 279  Bit Score: 166.08  E-value: 6.72e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  47 LSFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVTHLIFSI 126
Cdd:cd15193   3 IPILYLIIFFTGLLGNLFVIALMSKRSTTKRLVDTFVLNLAVADLVFVLTLPFWAASTALGGQWLFGEGLCKLSSFIIAV 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 127 NLFGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDTYYLKTVtsasnNETYCRsfypEHSIK 206
Cdd:cd15193  83 NRCSSILFLTGMSVDRYLAVVKLLDSRPLRTRRCALITCCIIWAVSLVLGIPSLVYRNLI-----NESVCV----EDSSS 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 207 EWLIGMELVSVVLGFAVPFSIIAVFYFLLARAI------SASSDQEKHSSRKIIFSYVVVFLVCWLPYHVAVLLDIFSIL 280
Cdd:cd15193 154 RFFQGISLATLFLTFVLPLIVILFCYCSILVRLrrhfhgAKRTGRRRRNSLRIVFAIVTAFVLSWLPFNTLKAVRLLLEL 233
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 31083344 281 HYIPFTCRLEHALFTALHVTQCLSLVHCCVNPVLYSFINRNYR 323
Cdd:cd15193 234 GGGVLPCHTTVAIRQGLTITACLAFVNSCVNPLIYSLLDRHFR 276
7tmA_CCR6 cd15172
CC chemokine receptor type 6, member of the class A family of seven-transmembrane G ...
49-323 1.48e-48

CC chemokine receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR6 is the only known receptor identified for the chemokine CCL20 (also known as macrophage inflammatory protein-3alpha, MIP-3alpha). CCR6 is expressed by all mature human B cells, effector memory T-cells, and dendritic cells found in the gut mucosal immune system. CCL20 contributes to recruitment of CCR6-expressing cells to Peyer's patches and isolated lymphoid follicles in the intestine, thereby promoting the assembly and maintenance of organized lymphoid structures. Also, CCL20 expression is highly inducible in response to inflammatory signals. Thus, CCL20 is involved in both inflammatory and homeostatic functions in the immune system. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341330 [Multi-domain]  Cd Length: 281  Bit Score: 164.93  E-value: 1.48e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  49 FIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSlvQHNQWPMGELTCKVTHLIFSINL 128
Cdd:cd15172   5 VIYSLICVVGLIGNSLVVITYAFYKRTKSMTDVYLLNMAIADILFVLTLPFWAVY--EAHQWIFGNFSCKLLRGIYAINF 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 129 FGSIFFLTCMSVDRYLSITYFTNTPSSRKKMV--RRVVCILVWLLAFCVSLPDTYYLKTVTSASNNETYCRSFYPEHS-I 205
Cdd:cd15172  83 YSGMLLLACISVDRYIAIVQATKSFRLRSRTLaySKLICAAVWLLAILISLPTFIFSEVYDFGLEEQYVCEPKYPKNStA 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 206 KEWLIGMELVSVVLGFAVPFSIIAVFYFLLARAISASSDQEKHSSRKIIFSYVVVFLVCWLPYHVAVLldIFSILHYIPF 285
Cdd:cd15172 163 IMWKLLVLSLQVSLGFFIPLLVMIFCYSFIIKTLLQAQNSQRHKAVRVVVAVVLVFLVCQVPYNIVLL--IEAINLGEQQ 240
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 31083344 286 TCRLEHALFTALHVTQCLSLVHCCVNPVLYSFINRNYR 323
Cdd:cd15172 241 SCSSEKAVAYAKTITECLAFFHCCLNPVLYAFIGVKFR 278
7tmA_Opioid_R-like cd14970
opioid receptors and related proteins, member of the class A family of seven-transmembrane G ...
46-323 5.49e-48

opioid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes opioid receptors, somatostatin receptors, melanin-concentrating hormone receptors (MCHRs), and neuropeptides B/W receptors. Together they constitute the opioid receptor-like family, members of the class A G-protein coupled receptors. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and are involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others. G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. MCHR binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Neuropeptides B/W receptors are primarily expressed in the CNS and stimulate the cortisol secretion by activating the adenylate cyclase- and the phospholipase C-dependent signaling pathways.


Pssm-ID: 320101 [Multi-domain]  Cd Length: 282  Bit Score: 163.62  E-value: 5.49e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  46 TLSFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVQHNqWPMGELTCKVTHLIFS 125
Cdd:cd14970   2 VIPAVYSVVCVVGLTGNSLVIYVILRYSKMKTVTNIYILNLAVADELFLLGLPFLATSYLLGY-WPFGEVMCKIVLSVDA 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 126 INLFGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDTYYLKTVTSASNNETyCRSFYPEHSi 205
Cdd:cd14970  81 YNMFTSIFCLTVMSVDRYLAVVHPVKSLRFRTPRKAKLVSLCVWALSLVLGLPVIIFARTLQEEGGTIS-CNLQWPDPP- 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 206 KEWLIGMELVSVVLGFAVPFSIIAVFYFLLAR------AISASSDQEKHSSRK----IIFSYVVVFLVCWLPYHVAVLld 275
Cdd:cd14970 159 DYWGRVFTIYTFVLGFAVPLLVITVCYSLIIRrlrssrNLSTSGAREKRRARRkvtrLVLVVVAVFVVCWLPFHVFQI-- 236
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 31083344 276 ifSILHYIPFTCRLEHALFtalHVTQCLSLVHCCVNPVLYSFINRNYR 323
Cdd:cd14970 237 --VRLLIDPPETLTVVGVF---LFCIALSYANSCLNPILYAFLDENFR 279
7tmA_CXCR5 cd15181
CXC chemokine receptor type 5, member of the class A family of seven-transmembrane G ...
49-326 1.71e-47

CXC chemokine receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR5 is a B-cell selective receptor that binds specifically to the homeostatic chemokine CXCL13 and regulates adaptive immunity. The receptor is found on all peripheral blood and tonsillar B cells and is involved in lymphocyte migration (homing) to specific tissues and development of normal lymphoid tissue. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341336 [Multi-domain]  Cd Length: 281  Bit Score: 162.22  E-value: 1.71e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  49 FIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVQhnQWPMGELTCKVTHLIFSINL 128
Cdd:cd15181   5 LAYSLVFLLGVVGNGLVLTILLRRRRSRRTTENYLLHLALADLLLLLTFPFSVVESIA--GWVFGTFLCKLVGAIHKLNF 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 129 FGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDTYYLKTVTSASNNETYCrSFYPEH-SIKE 207
Cdd:cd15181  83 YCSSLLLACISVDRYLAIVHAIHSYRHRRLRSVHLTCGSIWLVCFLLSLPNLVFLEVETSTNANRTSC-SFHQYGiHESN 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 208 WLIGMELVSVVLGFAVPFSIIAVFYFLLARAISASSDQ-EKHSSRKIIFSYVVVFLVCWLPYHVAVLLDIFSILHYIPFT 286
Cdd:cd15181 162 WWLTSRFLYHVVGFFLPLLIMGYCYATIVVTLCQSSRRlQKQKAIRVAILVTLVFCLCWLPYNIVIFLDTLDDLKAVVKN 241
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 31083344 287 CRLEHALFTALHVTQCLSLVHCCVNPVLYSFINRNYRYEL 326
Cdd:cd15181 242 CKLNDLLDAAITVTESLGFSHCCLNPILYAFIGVKFRNDL 281
7tmA_P2Y1-like cd15168
P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of ...
45-323 2.99e-47

P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14). This cluster only includes P2Y1-like receptors as well as other closely related orphan receptors, such as GPR91 (a succinate receptor) and GPR80/GPR99 (an alpha-ketoglutarate receptor).


Pssm-ID: 341329 [Multi-domain]  Cd Length: 284  Bit Score: 161.72  E-value: 2.99e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  45 YTLSFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVTHLIF 124
Cdd:cd15168   1 IFLPIVYGVVFLVGLLLNSVVLYRFIFHLKPWNSSAIYMFNLAVSDLLYLLSLPFLIYYYANGDHWIFGDFMCKLVRFLF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 125 SINLFGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDTYYLKtvTSASNNETYCRSFYPEHS 204
Cdd:cd15168  81 YFNLYGSILFLTCISVHRYLGICHPLRSLGKLKKRHAVAISVAVWILVLLQLLPILFFAT--TGRKNNRTTCYDTTSPEE 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 205 IKEWLIgMELVSVVLGFAVPFSIIAVFYFLLARAISASSDQ-----EKHSSRKIIFSYVVVFLVCWLPYHVAVLLDIFSI 279
Cdd:cd15168 159 LNDYVI-YSMVLTGLGFLLPLLIILACYGLIVRALIRKLGEgvtsaLRRKSIRLVIIVLALFAVCFLPFHVTRTINLAAR 237
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 31083344 280 LHYIPFTCRLEHALFTALHVTQCLSLVHCCVNPVLYSFINRNYR 323
Cdd:cd15168 238 LLSGTASCATLNGIYVAYKVTRPLASLNSCLNPLLYFLAGDKFR 281
7tmA_GPR17 cd15161
G protein-coupled receptor 17, member of the class A family of seven-transmembrane G ...
47-326 3.91e-46

G protein-coupled receptor 17, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR17 is a Forkhead box protein O1 (FOXO1) target and abundantly expressed in agouti-related peptide (AGRP) neurons. FOXO1 is a transcription factor that plays key roles in regulation of gluconeogenesis and glycogenolysis by insulin signaling. For instance, food intake and body weight increase when hypothalamic FOXO1 is activated, whereas they both decrease when FOXO1 is inhibited. However, a recent study has been reported that GPR17 deficiency in mice did not affect food intake or glucose homeostasis. Thus, GPR17 may not play a role in the control of food intake, body weight, or glycemic control. GPR17 is phylogenetically closely related to purinergic P2Y and cysteinyl-leukotriene receptors.


Pssm-ID: 320289 [Multi-domain]  Cd Length: 277  Bit Score: 158.72  E-value: 3.91e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  47 LSFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVTHLIFSI 126
Cdd:cd15161   3 FALFYILVFILAFPGNTLALWLFIHDRKSGTPSNVFLMHLAVADLSYVLILPMRLVYHLSGNHWPFGEVPCRLAGFLFYL 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 127 NLFGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDTYYLKTVTsaSNNETYCRSFYPEHSIK 206
Cdd:cd15161  83 NMYASLYFLACISVDRFLAIVHPVKSMKIRKPLYAHVVCGFLWVIVTVAMAPLLVSPQTVE--VNNTTVCLQLYREKASR 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 207 EwligmELVSVVLGFAVPFSIIAVFYFLLARAISASSDQEKHSSRK---IIFSYVVVFLVCWLPYHVAvllDIFSILHY- 282
Cdd:cd15161 161 G-----ALVSLAVAFTIPFVTTVTCYLLIIRSLRTGKREEKPLKDKaikMIILVLTIFLICFVPYHIS---RYIYILSHn 232
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 31083344 283 -IPFTCRLEHALFTALHVTQCLSLVHCCVNPVLYSFINRNYRYEL 326
Cdd:cd15161 233 gAGASCSSRRGLALANRITSCLTCLNGALDPVMYFFVAEKFRETL 277
7tmA_CCR7 cd15175
CC chemokine receptor type 7, member of the class A family of seven-transmembrane G ...
47-326 5.80e-44

CC chemokine receptor type 7, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR7 is a major homeostatic receptor responsible for lymph node development and effective adaptive immune responses and plays a critical role in trafficking of dendritic cells and B and T lymphocytes. Its only two ligands, CCL and CCl21, are primarily produced by stromal cells in the T cell zones of lymph nodes and spleen. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 341331 [Multi-domain]  Cd Length: 278  Bit Score: 153.00  E-value: 5.80e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  47 LSFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVQhnQWPMGELTCKVTHLIFSI 126
Cdd:cd15175   3 LPAMYSVICFLGLLGNGLVILTYIYFKRLKTMTDIYLLNLALADILFLLTLPFWAASAAK--KWVFGEEMCKAVYCLYKM 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 127 NLFGSIFFLTCMSVDRYLSITYFTNTPSSRKKMV--RRVVCILVWLLAFCVSLPDTYYLKTVTSASNNETYCRSfypeHS 204
Cdd:cd15175  81 SFFSGMLLLMCISIDRYFAIVQAASAHRHRSRAVfiSKVSSLGVWVLAFILSIPELLYSGVNNNDGNGTCSIFT----NN 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 205 IKEWLIGMELVSVVLGFAVPFSIIAVFYFLLARAISASSDQEKHSSRKIIFSYVVVFLVCWLPYHVAVLLDIFSILHYIP 284
Cdd:cd15175 157 KQTLSVKIQISQMVLGFLVPLVVMSFCYSVIIKTLLQARNFEKNKAIKVIIAVVVVFVVFQLPYNSVMLVSTLSSFKGNT 236
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 31083344 285 FTCRLEHALFTALHVTQCLSLVHCCVNPVLYSFINRNYRYEL 326
Cdd:cd15175 237 TDCDYSKNLDFALDVTYSLACFRCCLNPFLYAFIGVKFRNDL 278
7tmA_Anaphylatoxin_R-like cd14974
anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class ...
50-323 1.61e-43

anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes anaphylatoxin receptors, formyl peptide receptors (FPR), prostaglandin D2 receptor 2, GPR1, and related chemokine receptors. The anaphylatoxin receptors are a group of G-protein coupled receptors that bind anaphylatoxins. The members of this group include C3a and C5a receptors. The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed mainly on polymorphonuclear and mononuclear phagocytes and bind N-formyl-methionyl peptides (FMLP), which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Chemokine receptor-like 1 (also known as chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. Prostaglandin D2 receptor, also known as CRTH2, is a chemoattractant G-protein coupled receptor expressed on T helper type 2 cells that binds prostaglandin D2 (PGD2). PGD2 functions as a mast cell-derived mediator to trigger asthmatic responses and also causes vasodilation. PGD2 exerts its inflammatory effects by binding to two G-protein coupled receptors, the D-type prostanoid receptor (DP) and PD2R2 (CRTH2). PD2R2 couples to the G protein G(i/o) type which leads to a reduction in intracellular cAMP levels and an increase in intracellular calcium. GPR1 is an orphan receptor that can be activated by the leukocyte chemoattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1.


Pssm-ID: 320105 [Multi-domain]  Cd Length: 274  Bit Score: 151.68  E-value: 1.61e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  50 IYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYiLNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVTHLIFSINLF 129
Cdd:cd14974   6 LYALIFLLGLPGNGLVIWVAGFKMKRTVNTVWF-LNLALADFLFCLFLPFLIVYIAMGHHWPFGSVLCKLNSFVISLNMF 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 130 GSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDTYYLKTVTsaSNNETYCRSFYPEH-----S 204
Cdd:cd14974  85 ASVFLLTAISLDRCLLVLHPVWAQNHRTVRLASVVCVGIWILALVLSVPYFVFRDTVT--HHNGRSCNLTCVEDydlrrS 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 205 IKEWLIGMELvsvVLGFAVPFSIIAVFYFLLARAISASSDQEKHSSRKIIFSYVVVFLVCWLPYHVAVLLDIfSILHYIP 284
Cdd:cd14974 163 RHKALTVIRF---LCGFLLPLLIIAICYSVIAVKLRRKRLAKSSKPLRVLLAVVVAFFLCWLPYHVFALLEL-VAAAGLP 238
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 31083344 285 ftcrleHALFTALHVTQCLSLVHCCVNPVLYSFINRNYR 323
Cdd:cd14974 239 ------EVVLLGLPLATGLAYFNSCLNPILYVFMGQDFR 271
7tmA_CCR9 cd15174
CC chemokine receptor type 9, member of the class A family of seven-transmembrane G ...
45-326 3.69e-43

CC chemokine receptor type 9, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR9 is a homeostatic receptor specific for CCL25 (formerly known as thymus expressed chemokine) and is highly expressed on both immature and mature thymocytes as well as on intestinal homing T Lymphocytes and mucosal Lymphocytes. In cutaneous melanoma, activation of CCR9-CCL25 has been shown to stimulate metastasis to the small intestine. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. The CC chemokine receptors are all activating the G protein Gi.


Pssm-ID: 320302 [Multi-domain]  Cd Length: 280  Bit Score: 151.06  E-value: 3.69e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  45 YTLSFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVQhnQWPMGELTCKVTHLIF 124
Cdd:cd15174   1 YFLPPLYWLIFLVGAVGNSLVVLIYTYYRRRKTMTDVYLLNLAIADLLFLCTLPFWATAASS--GWVFGTFLCKVVNSMY 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 125 SINLFGSIFFLTCMSVDRYLSITYFTNTPSSRKK--MVRRVVCILVWLLAFCVSLPDTYYLKTVTSASNneTYCRSFYPE 202
Cdd:cd15174  79 KINFYSCMLLLTCISVDRYIAIVQATKAHNSKNKrlLYSKLVCFFVWLLSTILSLPEILFSQSKEEESV--TTCTMVYPS 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 203 HSIKEWLIGMELVSVVLGFAVPFSIIAVFYFLLARAISASSDQEKHSSRKIIFSYVVVFLVCWLPYHVAVLLDIFSILHY 282
Cdd:cd15174 157 NESNRFKVAVLALKVTVGFFLPFVVMVICYTLIIHTLLQAKRFQKHKALKVIIAVVTVFVLSQLPYNSILLIKTINAYNI 236
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 31083344 283 IPFTCRLEHALFTALHVTQCLSLVHCCVNPVLYSFINRNYRYEL 326
Cdd:cd15174 237 TITDCATSQNLDIAGQVTQSIAFLHSCLNPFLYVFVGVRFRKDL 280
7tmA_RNL3R cd14976
relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G ...
47-323 2.53e-42

relaxin-3 like peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This G protein-coupled receptor subfamily is composed of the relaxin-3 like peptide receptors, RNL3R1 and RNL3R2, and similar proteins. The relaxin-3 like peptide family includes relaxin-1, -2, -3, as well as insulin-like (INSL) peptides 3 to 6. RNL3/relaxin-3 and INSL5 are the endogenous ligands for RNL3R1 and RNL3R2, respectively. RNL3R1, also called GPCR135 or RXFP3, is predominantly expressed in the brain and is implicated in stress, anxiety, feeding, and metabolism. Insulin-like peptide 5 (INSL5), the endogenous ligand for RNL3R2 (also called GPCR142 or RXFP4), plays a role in fat and glucose metabolism. INSL5 is highly expressed in human rectal and colon tissues. Both RNL3R1 and RNL3R2 signal through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation. RNL3R1 is shown to activate Erk1/2 signaling pathway.


Pssm-ID: 320107 [Multi-domain]  Cd Length: 290  Bit Score: 149.19  E-value: 2.53e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  47 LSFIYIFIFVIGMIANSVVVWV--NIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVTHLIF 124
Cdd:cd14976   3 VSVVYMVVFTVGLLGNLLVLYLlkSNKKLRQQSESNKFVFNLALTDLIFVLTLPFWAVEYALDFVWPFGTAMCKVVRYVT 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 125 SINLFGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDTYYlKTVTSASNNETYCRSFYPEHS 204
Cdd:cd14976  83 KLNMYSSIFFLTALSVTRYIAVARALKHGWIRKAFGAFATTIAIWAAAALAAIPEAIF-STDTWSSVNHTLCLLRFPKNS 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 205 IKE----WLIGMELVSVVLGFAVPFSIIAVFYFLLARAIS---ASSDQEKHSSRKIIFSYVVVFLVCWLPYHVAVLLDIF 277
Cdd:cd14976 162 SVTrwynWLGMYQLQKVVLGFFLPLGIITLSYLLLLRFLQrkrGGSKRRKSRVTKSVFIVVLSFFICWLPNQALSLWSAL 241
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 31083344 278 SILHYIPFTCRLEHALFTALHVTQCLSLVHCCVNPVLYSFINRNYR 323
Cdd:cd14976 242 IKFDDVPFSDAFFAFQTYAFPVAICLAHSNSCLNPVLYCLVRREFR 287
7tmA_CCR8 cd15187
CC chemokine receptor type 8, member of the class A family of seven-transmembrane G ...
47-326 4.56e-42

CC chemokine receptor type 8, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR8, the receptor for the CC chemokines CCL1 and CC16, is highly expressed on allergen-specific T-helper type 2 cells, and is implicated in the pathogenesis of human asthma. CCL1- and CCR8-expressing CD4+ effector T lymphocytes are shown to have a critical role in lung mucosal inflammatory responses. CCR8 is also a functional receptor for CCL16, a liver-expressed CC chemokine that involved in attracting lymphocytes, dendritic cells, and monocytes. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320315 [Multi-domain]  Cd Length: 276  Bit Score: 148.02  E-value: 4.56e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  47 LSFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVqhNQWPMGELTCKVTHLIFSI 126
Cdd:cd15187   3 LPVLYCLLFVFGLLGNSLVIWVLVACKKLRSMTDVYLLNLAASDLLFVFSLPFQAYYLL--DQWVFGNAMCKIVSGAYYI 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 127 NLFGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDTYYLKTVTsaSNNETYCRSFYPEHSIK 206
Cdd:cd15187  81 GFYSSMFFITLMSIDRYLAIVHAVYALKVRTASHGTILSLALWLVAILASVPLLVFYQVAS--EDGRLQCIPFYPGQGNS 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 207 eWLIGMELVSVVLGFAVPFSIIAVFYFLLARAISASSDQEKHSSRKIIFSYVVVFLVCWLPYHVAVLLDIFSILHYIPfT 286
Cdd:cd15187 159 -WKVFTNFEVNILGLLIPFSILIFCYHNILRNLRRCHNQNKTKAIKLVFIVVIVFFLFWTPFNVVLFLDSLHSLHIID-G 236
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 31083344 287 CRLEHALFTALHVTQCLSLVHCCVNPVLYSFINRNYRYEL 326
Cdd:cd15187 237 CQNSQRLTLALHLTETISFTHCCLNPVIYAFVGEKFKKHL 276
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
47-319 4.85e-42

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 147.82  E-value: 4.85e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  47 LSFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVTHLIFSI 126
Cdd:cd00637   1 LAVLYILIFVVGLVGNLLVILVILRNRRLRTVTNYFILNLAVADLLVGLLVIPFSLVSLLLGRWWFGDALCKLLGFLQSV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 127 NLFGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDTYYLKTVTsaSNNETYCRSFYPEHSIK 206
Cdd:cd00637  81 SLLASILTLTAISVDRYLAIVHPLRYRRRFTRRRAKLLIALIWLLSLLLALPPLLGWGVYD--YGGYCCCCLCWPDLTLS 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 207 EWLIgmeLVSVVLGFAVPFSIIAVFYFLLARAISASSDQEKHSSR---------------KIIFSYVVVFLVCWLPYHVA 271
Cdd:cd00637 159 KAYT---IFLFVLLFLLPLLVIIVCYVRIFRKLRRHRRRIRSSSSnssrrrrrrrerkvtKTLLIVVVVFLLCWLPYFIL 235
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 31083344 272 VLLDIFSILHYipftcrleHALFTALHVTQCLSLVHCCVNPVLYSFIN 319
Cdd:cd00637 236 LLLDVFGPDPS--------PLPRILYFLALLLAYLNSAINPIIYAFFN 275
7tmA_EBI2 cd15159
Epstein-Barr virus (EBV)-induced gene 2, member of the class A family of seven-transmembrane G ...
45-323 1.94e-41

Epstein-Barr virus (EBV)-induced gene 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Epstein-Barr virus-induced G-protein coupled receptor 2 (EBI2), also called GPR183, is activated by 7alpha, 25-dihydroxyxcholesterol (7alpha, 25-OHC), an oxysterol. EBI2 was originally identified as one of major genes induced in the Burkitt's lymphoma cell line BL41by EBV infection. EBI2 is involved in regulating B cell migration and responses, and is also implicated in human diseases such as type I diabetes, multiple sclerosis, and cancers.


Pssm-ID: 320287 [Multi-domain]  Cd Length: 286  Bit Score: 146.73  E-value: 1.94e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  45 YTLSFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVTHLIF 124
Cdd:cd15159   1 VLLPLFYSLILVFGLLGNTLALHVICQKRKKINSTTLYLINLAVSDILFTLALPGRIAYYALGFDWPFGDWLCRLTALLF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 125 SINLFGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPdtYYLKTVTSASNNETYCRSFYPEHS 204
Cdd:cd15159  81 YINTYAGVNFMTCLSVDRYIAVVHPLRRHRLRKVKVVRYICVFVWVLVFLQTLP--LLFMPMTKEMGGRITCMEYPNFEK 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 205 IKEwLIGMELVSVVLGFAVPFSIIAVFY-------FLLARAISASSDQEKHS-SRKIIFSYVVVFLVCWLPYHVAVLLDI 276
Cdd:cd15159 159 IKR-LPLILLGACVIGFGVPVGIILFCYsqitlklCRTAKENPLTEKSGHHKkACNVILLVLLVFVVCFSPYHLNIIQFM 237
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 31083344 277 FSILHYIPfTCRLEHALFTALHVTQCLSLVHCCVNPVLYSFINRNYR 323
Cdd:cd15159 238 IRKLLYQP-SCSELKAFKISLQITVCLMNLNCCLDPFIYFFACKGYK 283
7tmA_XCR1 cd15182
XC chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
47-326 2.30e-41

XC chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; XCR1 is a chemokine receptor specific for XCL1 and XCL2 (previously called lymphotactin alpha/beta), which differ in only two amino acids. XCL1/2 is the only member of the C chemokine subfamily, which is unique as containing only two of the four cysteines that are found in other chemokine families. Human XCL1/2 has been shown to be secreted by activated CD8+ T cells and upon activation of the innate immune system. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling.


Pssm-ID: 341337 [Multi-domain]  Cd Length: 271  Bit Score: 145.97  E-value: 2.30e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  47 LSFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSlvQHNQWPMGELTCKVTHLIFSI 126
Cdd:cd15182   3 LPVFYYLVFLLSLLGNGLVLWILVKYEKLKTLTNIFILNLAISDLLFTFTLPFWASY--HSSGWIFGEILCKAVTSIFYI 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 127 NLFGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDTYYLKTVTSASNNeTYCrsfypEHSIK 206
Cdd:cd15182  81 GFYSSILFLTLMTIDRYLAVVHPLSALRSRKLRYASLVSVAVWVISILASLPELILSTVMKSDEDG-SLC-----EYSSI 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 207 EWLIGMELVSVVLgFAVPFSIIAVFYFLLARAISASSDQEKHSSRKIIFSYVVVFLVCWLPYHVAVLLDIFSILHYipFT 286
Cdd:cd15182 155 KWKLGYYYQQNLF-FLIPLGIIVYCYVRILQTLMRTRTMRKHRTVKLIFVIVLVFFLSWAPYNIVIFLRSLKDLTI--PI 231
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 31083344 287 CRLEHALFTALHVTQCLSLVHCCVNPVLYSFINRNYRYEL 326
Cdd:cd15182 232 CECSKQLDYAFYICRNIAFSHCCLNPVFYVFVGVKFRNHL 271
7tmA_SSTR cd15093
somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
47-323 3.20e-41

somatostatin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. They share common signaling cascades such as inhibition of adenylyl cyclase, activation of phosphotyrosine phosphatase activity, and G-protein-dependent regulation of MAPKs.


Pssm-ID: 320221 [Multi-domain]  Cd Length: 280  Bit Score: 146.07  E-value: 3.20e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  47 LSFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPvWVVSLVQHNQWPMGELTCKVTHLIFSI 126
Cdd:cd15093   3 IPCIYAVVCLVGLCGNSLVIYVVLRYAKMKTVTNIYILNLAIADELFMLGLP-FLAASNALRHWPFGSVLCRLVLSVDGI 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 127 NLFGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDTYYLKTvTSASNNETYCRSFYPEhSIK 206
Cdd:cd15093  82 NMFTSIFCLTVMSVDRYLAVVHPIKSARWRRPRVAKVVNLAVWVASLLVILPVVVFAGT-RENQDGSSACNMQWPE-PAA 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 207 EWLIGMELVSVVLGFAVPFSIIAVFYFLLAR-----AISASSDQEKHSSRKI---IFSYVVVFLVCWLPYHVAVLLDIFS 278
Cdd:cd15093 160 AWSAGFIIYTFVLGFLLPLLIICLCYLLIVIkvksaGLRAGWQQRKRSERKVtrmVVMVVVVFVICWLPFYVLQLVNVFV 239
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 31083344 279 ILHYIPFtcrlehaLFTALHVTQCLSLVHCCVNPVLYSFINRNYR 323
Cdd:cd15093 240 QLPETPA-------LVGVYHFVVILSYANSCANPILYGFLSDNFK 277
7tmA_GPR4 cd15366
proton-sensing G protein-coupled receptor 4, member of the class A family of ...
50-326 5.55e-41

proton-sensing G protein-coupled receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein-coupled receptor 4 (GPR4) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 receptor (TDAG8, GPR65), ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. GPR4 overexpression in melanoma cells was shown to reduce cell migration, membrane ruffling, and cell spreading under acidic pH conditions. Activation of GPR4 via extracellular acidosis is coupled to the G(s), G(q), and G(12/13) pathways.


Pssm-ID: 320488 [Multi-domain]  Cd Length: 280  Bit Score: 145.32  E-value: 5.55e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  50 IYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVTHLIFSINLF 129
Cdd:cd15366   6 LYIIVIVLGLPTNCLALWAAYLQVRQRNELGVYLLNLSVSDLLYIATLPLWIDYFLHRDNWIHGPESCKLFGFIFYTNIY 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 130 GSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDTYYlKTVTSASNNETYCRSFYPehsIKEWL 209
Cdd:cd15366  86 ISIAFLCCISVDRYLAVAHPLRFAKVRRVKTAVAVSAVVWAIEIGANSAPLFH-DELFRDRYNHTFCFEKYP---MEDWV 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 210 IGMELVSVVLGFAVPFSIIAVFYFLLARAISASSDQEKHSSRKI---IFSYVVVFLVCWLPYHVaVLLDIFSILHYIPFT 286
Cdd:cd15366 162 AWMNLYRVFVGFLFPWVLMLFSYRGILRAVRGNVSTEQQEKAKIkrlALSLIAIVLLCFAPYHV-LLLSRSVVYLGKPCD 240
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 31083344 287 CRLEHALFTALHVTQCLSLVHCCVNPVLYSFINRNYRYEL 326
Cdd:cd15366 241 CGFEERVFTAYHVSLALTSLNCVADPILYCLVNEGARSDV 280
7tmA_CXCR6 cd15173
CXC chemokine receptor type 6, member of the class A family of seven-transmembrane G ...
45-323 1.11e-40

CXC chemokine receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR6 binds specifically to the chemokine CXCL16, which is expressed on dendritic cells, monocyte/macrophages, activated T cells, fibroblastic reticular cells, and cancer cells. CXCR6 is phylogenetically more closely related to CC-type chemokine receptors (CCR6 and CCR9) than other CXC receptors. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320301 [Multi-domain]  Cd Length: 270  Bit Score: 144.14  E-value: 1.11e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  45 YTLSFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVQhnQWPMGELTCKVTHLIF 124
Cdd:cd15173   1 YFLPCMYSVMFVTGLVGNSLVIVIYIFYEKLRTLTDIFLVNLAVADLLFLCTLPFWAYSAAH--EWIFGTVMCKITNGLY 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 125 SINLFGSIFFLTCMSVDRYLSITYFT--NTPSSRKKMVRRVVCILVWLLAFCVSLPDTYYLKTVTSASnneTYCRSFYPE 202
Cdd:cd15173  79 TINLYSSMLILTCITVDRFIVIVQATkaHNCHAKKMRWGKVVCTLVWVISLLLSLPQFIYSEVRNLSS---KICSMVYPP 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 203 HSIKEWLIGMELvsvVLGFAVPFSIIAVFYFLLARAISASSDQEKHSSRKIIFSYVVVFLVCWLPYHVAVLLDIFSILHY 282
Cdd:cd15173 156 DAIEVVVNIIQM---TVGFFLPLLAMIICYSVIIKTLLHAKGFQKHKSLKIIFVVVAVFILTQLPYNIMKLIRTLHIENT 232
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 31083344 283 ipftcrLEHALFTALHVTQCLSLVHCCVNPVLYSFINRNYR 323
Cdd:cd15173 233 ------DSTNFKYAILITEAIAYLHACLNPILYAFVGVKFR 267
7tmA_CX3CR1 cd15186
CX3C chemokine receptor 1, member of the class A family of seven-transmembrane G ...
47-323 1.13e-40

CX3C chemokine receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; CX3CR1 is an inflammatory receptor specific for CX3CL1 (also known as fractalkine in human), which is involved in the adhesion and migration of leukocytes. The CX3C chemokine subfamily is only represented by CX3CL1, which exists in both soluble and membrane-anchored forms. Membrane-anchored form promotes strong adhesion of receptor-bearing leukocytes to CX3CL1-expressing endothelial cells. On the other hand, soluble CX3CL1, which is released by the proteolytic cleavage of membrane-anchored CX3CL1, is a potent chemoattractant for CX3CR1-expressing T cells and monocytes. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling.


Pssm-ID: 320314 [Multi-domain]  Cd Length: 273  Bit Score: 144.21  E-value: 1.13e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  47 LSFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVqhNQWPMGELTCKVTHLIFSI 126
Cdd:cd15186   3 LSIFYSLVFAFGLVGNLLVVLALTNSGKSKSITDIYLLNLALSDLLFVATLPFWTHYLI--NEWGLHNAMCKLTTAFFFI 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 127 NLFGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDTYYLKtvtsasNNETYCRSFYPEHSIK 206
Cdd:cd15186  81 GFFGGIFFITVISIDRYLAIVLAANSMNNRTVQHGVTISLGVWAAAILVAVPQFMFTK------MKENECLGDYPEVLQE 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 207 EWLIGMELVSVVLGFAVPFSIIAVFYFLLARAISASSDQEKHSSRKIIFSYVVVFLVCWLPYHVAVLLDIFSILHYIPfT 286
Cdd:cd15186 155 IWPVLRNVELNFLGFLLPLLIMSYCYFRIIQTLFSCKNHKKARAIKLILLVVIVFFLFWTPYNVMIFLETLKLYDFFP-S 233
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 31083344 287 CRLEHALFTALHVTQCLSLVHCCVNPVLYSFINRNYR 323
Cdd:cd15186 234 CDMKKDLRLALSVTETIAFSHCCLNPLIYAFAGEKFR 270
7tmA_ACKR2_D6 cd15188
atypical chemokine receptor 2, member of the class A family of seven-transmembrane G ...
47-326 2.53e-40

atypical chemokine receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; ACKR2 (also known as D6) binds non-selectively to all inflammatory CC-chemokines, but not to homeostatic CC-chemokines involved in controlling the migration of cells. Unlike the classical chemokine receptors that contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 320316 [Multi-domain]  Cd Length: 278  Bit Score: 143.39  E-value: 2.53e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  47 LSFIYIFIFVIGMIANSVVVWVNIQ-AKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVQHnqWPMGELTCKVTHLIFS 125
Cdd:cd15188   3 LPVFYTLVFLLGLAGNLLLFVVLLLyVPKKKKMTEVYLLNLAVSDLLFLVTLPFWAMYVAWH--WVFGSFLCKFVSTLYT 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 126 INLFGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDTYYLKTVTSASNNETYCRSFYPEHSI 205
Cdd:cd15188  81 INFYSGIFFVSCMSLDKYLEIVHAQSPHRLRTRRKSLLVLVAVWVLSIALSVPDMVFVQTHHTNNGVWVCHADYGGHHTI 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 206 keWLIGMELVSVVLGFAVPFSIIAVFYFLLARAISASSDQEKHSSRKIIFSYVVVFLVCWLPYHVAVLLDIFSILHYIPf 285
Cdd:cd15188 161 --WKLVFQFQQNLLGFLFPLLAMVFFYSRIACVLTRLRPPGQGRALRFVAALVVVFFVLWFPYNLTLFLHSLQDLHVIG- 237
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 31083344 286 TCRLEHALFTALHVTQCLSLVHCCVNPVLYSFINRNYRYEL 326
Cdd:cd15188 238 NCERSRHLDYALQVTESLAFVHCCLNPLLYAFVSKRFRLYL 278
7tmA_SSTR1 cd15970
somatostatin receptor type 1, member of the class A family of seven-transmembrane G ...
47-323 2.01e-39

somatostatin receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR1 is coupled to a Na/H exchanger, voltage-dependent calcium channels, and AMPA/kainate glutamate channels. SSTR1 is expressed in the normal human pituitary and in nearly half of all pituitary adenoma subtypes.


Pssm-ID: 320636 [Multi-domain]  Cd Length: 276  Bit Score: 141.20  E-value: 2.01e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  47 LSFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVQHnQWPMGELTCKVTHLIFSI 126
Cdd:cd15970   3 ISFIYSVVCLVGLCGNSMVIYVILRYAKMKTATNIYILNLAIADELLMLSVPFLVTSTLLR-HWPFGSLLCRLVLSVDAI 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 127 NLFGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDTYYLKTVTsASNNETYCRSFYPEHSiK 206
Cdd:cd15970  82 NMFTSIYCLTVLSIDRYIAVVHPIKAARYRRPTVAKMVNLGVWVFSILVILPIIIFSNTAP-NSDGSVACNMQMPEPS-Q 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 207 EWLIGMELVSVVLGFAVPFSIIAVFYFLL-----ARAISASSDQEKHSSRKI---IFSYVVVFLVCWLPYHVAVLLDIFs 278
Cdd:cd15970 160 RWLAVFVVYTFLMGFLLPVIAICLCYILIivkmrVVALKAGWQQRKRSERKItlmVMMVVTVFVICWMPFYVVQLVSVF- 238
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 31083344 279 ilhyipftcrLEHALFTALHVTQCLSLVHCCVNPVLYSFINRNYR 323
Cdd:cd15970 239 ----------VGQHDATVSQLSVILGYANSCANPILYGFLSDNFK 273
7tmA_C5aR cd15114
complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of ...
49-326 3.44e-39

complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The anaphylatoxin receptors are a group of G-protein coupled receptors which bind anaphylatoxins; members of this group include C3a receptors and C5a receptors. Anaphylatoxins are also known as complement peptides (C3a, C4a and C5a) that are produced from the activation of the complement system cascade. These complement anaphylatoxins can trigger degranulation of endothelial cells, mast cells, or phagocytes, which induce a local inflammatory response and stimulate smooth muscle cell contraction, histamine release, and increased vascular permeability. They are potent mediators involved in chemotaxis, inflammation, and generation of cytotoxic oxygen-derived free radicals. In humans, a single receptor for C3a (C3AR1) and two receptors for C5a (C5AR1 and C5AR2, also known as C5L2 or GPR77) have been identified, but there is no known receptor for C4a.


Pssm-ID: 320242 [Multi-domain]  Cd Length: 274  Bit Score: 140.23  E-value: 3.44e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  49 FIYIFIFVIGMIANSVVVWVniqaktTGYDTH-----CYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVTHLI 123
Cdd:cd15114   5 VLYAVVFLVGVPGNALVAWV------TGFEAKrsvnaVWFLNLAVADLLCCLSLPILAVPIAQDGHWPFGAAACKLLPSL 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 124 FSINLFGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDTYYLKTVTSASNNETYCRSFYPEH 203
Cdd:cd15114  79 ILLNMYASVLLLTAISADRCLLVLRPVWCQNHRRARLAWIACGAAWLLALLLTVPSFIYRRIHQEHFPEKTVCVVDYGGS 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 204 SIKEWLIGmeLVSVVLGFAVPFSIIAVFYFLLARAISASSDQEKHSSRKIIFSYVVVFLVCWLPYHVAVLLDIFSILHyi 283
Cdd:cd15114 159 TGVEWAVA--IIRFLLGFLGPLVVIASCHGVLLVRTWSRRRQKSRRTLKVVTAVVVGFFLCWTPYHVVGLIIAASAPN-- 234
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 31083344 284 pftCRLEHALFTALHVTQCLSLVHCCVNPVLYSFINRNYRYEL 326
Cdd:cd15114 235 ---SRLLANALKADPLTVSLAYINSCLNPIIYVVAGRGFRKSL 274
PHA03087 PHA03087
G protein-coupled chemokine receptor-like protein; Provisional
46-339 7.51e-39

G protein-coupled chemokine receptor-like protein; Provisional


Pssm-ID: 222976 [Multi-domain]  Cd Length: 335  Bit Score: 141.07  E-value: 7.51e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344   46 TLSFIYIFIFVIGMIANSVVVWVNIQAKTTGYdTHCYILNLAIADLWVVLTIPVWVVSlVQHNQWPMGELTCKVTHLIFS 125
Cdd:PHA03087  42 ILIVVYSTIFFFGLVGNIIVIYVLTKTKIKTP-MDIYLLNLAVSDLLFVMTLPFQIYY-YILFQWSFGEFACKIVSGLYY 119
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  126 INLFGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPdtYYLKTVTSASNNETYCRSFYPEHSi 205
Cdd:PHA03087 120 IGFYNSMNFITVMSVDRYIAIVHPVKSNKINTVKYGYIVSLVIWIISIIETTP--ILFVYTTKKDHETLICCMFYNNKT- 196
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  206 KEWLIGMELVSVVLGFAVPFSIIAVFYF-LLARAISASSDQEKHSSRKIIFSYVVVFLVCWLPYHVAVLLDIFSILHYIP 284
Cdd:PHA03087 197 MNWKLFINFEINIIGMLIPLTILLYCYSkILITLKGINKSKKNKKAIKLVLIIVILFVIFWLPFNVSVFVYSLHILHFKS 276
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 31083344  285 fTCRLEHALFTALHVTQCLSLVHCCVNPVLYSFINRNYRYELMKAFIFKYSAKTG 339
Cdd:PHA03087 277 -GCKAVKYIQYALHVTEIISLSHCCINPLIYAFVSEFFNKHKKKSLKLMFTSSGK 330
7tmA_AstC_insect cd15094
somatostatin-like receptor for allatostatin C, member of the class A family of ...
50-323 1.55e-38

somatostatin-like receptor for allatostatin C, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. In Drosophila melanogaster and other insects, a 15-amino-acid peptide named allatostatin C(AstC) binds the somatostatin-like receptors. Two AstC receptors have been identified in Drosophila with strong sequence homology to human somatostatin and opioid receptors.


Pssm-ID: 320222 [Multi-domain]  Cd Length: 282  Bit Score: 138.76  E-value: 1.55e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  50 IYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVQhNQWPMGELTCKVTHLIFSINLF 129
Cdd:cd15094   6 LYGLICIVGLVGNGLVIYVVLRYAKMKTVTNLYILNLAVADECFLIGLPFLIVTMIL-KYWPFGAAMCKIYMVLTSINQF 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 130 GSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDTYYLKTVTSASNNEtyCRSFYPEHSIKEWL 209
Cdd:cd15094  85 TSSFTLTVMSADRYLAVCHPIRSMRYRTPFIAKVVCATTWSISFLVMLPIILYASTVPDSGRYS--CTIVWPDSSAVNGQ 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 210 IGMELVSVVLGFAVPFSIIAVFYFLLARAISA-----SSDQEKHSSRKI---IFSYVVVFLVCWLPYHVAVLLDIFSilh 281
Cdd:cd15094 163 KAFTLYTFLLGFAIPLLLISVFYTLVILRLRTvgpknKSKEKRRSHRKVtrlVLTVISVYIICWLPYWAFQVHLIFL--- 239
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 31083344 282 yiPFTCRLEHALFTALHVTQCLSLVHCCVNPVLYSFINRNYR 323
Cdd:cd15094 240 --PPGTDMPKWEILMFLLLTVLSYANSMVNPLLYAFLSENFR 279
7tmA_CCR1 cd15183
CC chemokine receptor type 1, member of the class A family of seven-transmembrane G ...
47-323 6.30e-38

CC chemokine receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR1 is widely expressed on both hematopoietic and non-hematopoietic cells and binds to the inflammatory CC chemokines CCL3, CCL5, CCL6, CCL9, CCL15, and CCL23. CCR1 activates the typical chemokine signaling pathway through the G(i/o) type of G proteins, causing inhibition of adenylate cyclase and stimulation of phospholipase C, PKC, calcium flux, and PLA2. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 320311 [Multi-domain]  Cd Length: 278  Bit Score: 137.31  E-value: 6.30e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  47 LSFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWvVSLVQHNQWPMGELTCKVTHLIFSI 126
Cdd:cd15183   3 LPPLYSLVFIIGVVGNVLVVLVLIQHKRLRNMTSIYLFNLAISDLVFLFTLPFW-IDYKLKDDWIFGDAMCKFLSGFYYL 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 127 NLFGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDTYYLKTVTSASNNEtyCRSFYPEHSIK 206
Cdd:cd15183  82 GLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGIITSIITWALAILASMPCLYFFKSQWEFTHHT--CSAHFPRKSLI 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 207 EWLIGMELVSVVLGFAVPFSIIAVFYFLLARAISASSDQEKHSSRKIIFSYVVVFLVCWLPYHVAVLLDIFSILHYIPfT 286
Cdd:cd15183 160 RWKRFQALKLNLLGLILPLLVMIICYTGIINILLRRPNEKKAKAVRLIFVITLLFFLLWTPYNLAAFVSAFQDVLFTP-S 238
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 31083344 287 CRLEHALFTALHVTQCLSLVHCCVNPVLYSFINRNYR 323
Cdd:cd15183 239 CEQSQQLDLALQVTEVIAYTHCCVNPVIYVFVGERFR 275
7tmA_LTB4R cd14975
leukotriene B4 receptors, member of the class A family of seven-transmembrane G ...
55-320 1.45e-37

leukotriene B4 receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the G(q)-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320106 [Multi-domain]  Cd Length: 278  Bit Score: 136.07  E-value: 1.45e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  55 FVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVqHNQWPMGELTCKVTHLIFSINLFGSIFF 134
Cdd:cd14975  11 FAIGLPGNSFVIWSILIKVKQRSVTMLLVLNLALADLAVLLTLPVWIYFLA-TGTWDFGLAACKGCVYVCAVSMYASVFL 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 135 LTCMSVDRYLSITY-FTNTPSSRKKMVRRVVCILvWLLAFCVSLPDTYYLKTVTSAsnNETYCrsfYPEHSIKEWLIGME 213
Cdd:cd14975  90 ITLMSLERFLAVSRpFVSQGWRAKALAHKVLAII-WLLAVLLATPVIAFRHVEETV--ENGMC---KYRHYSDGQLVFHL 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 214 LVSVVLGFAVPFSIIAVFYFLLARAISASSDQEKHSSRKIIFSYVVVFLVCWLPYHVAVLLDIFSILHY-IPFTCRLEHA 292
Cdd:cd14975 164 LLETVVGFAVPFTAVVLCYSCLLRRLRRRRFRRRRRTGRLIASVVVAFAACWLPYHVGNLLEVVSELIGgSKMAGTLGKV 243
                       250       260
                ....*....|....*....|....*...
gi 31083344 293 LFTALHVTQCLSLVHCCVNPVLYSFINR 320
Cdd:cd14975 244 AEAGRPIAGALAFLSSSINPLLYAFAAR 271
7tmA_CCR3 cd15185
CC chemokine receptor type 3, member of the class A family of seven-transmembrane G ...
50-326 1.62e-37

CC chemokine receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR3 is a highly promiscuous receptor that binds a variety of inflammatory CC-type chemokines, including CCL11 (eotaxin-1), CCL3L1, CCL5 (regulated on activation, normal T cell expressed and secreted; RANTES), CCL7 (monocyte-specific chemokine 3 or MCP-3), CCL8 (MCP-2), CCL11, CCL13 (MCP-4), CCL15, CCL24 (eotaxin-2), CCL26 (eotaxin-3), and CCL28. Among these, the eosinophil chemotactic chemokines (CCL11, CCL24, and CCL26) are the most potent and specific ligands. In addition to eosinophil, CCR3 is expressed on cells involved in allergic responses, such as basophils, Th2 lymphocytes, and mast cells. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341339 [Multi-domain]  Cd Length: 278  Bit Score: 136.11  E-value: 1.62e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  50 IYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWvVSLVQHNQWPMGELTCKVTHLIFSINLF 129
Cdd:cd15185   6 LYSLVFIVGLLGNVVVVVILIKYRRLRIMTNIYLLNLAISDLLFLFTLPFW-IHYVRWNNWVFGHGMCKLLSGFYYLGLY 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 130 GSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDTYYLKtvTSASNNETYCRSFYPEHSIKEWL 209
Cdd:cd15185  85 SEIFFIILLTIDRYLAIVHAVFALRARTVTFGIITSIITWGLAVLAALPEFIFYE--TQELFEEFLCSPLYPEDTEDSWK 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 210 IGMELVSVVLGFAVPFSIIAVFYFLLARAISASSDQEKHSSRKIIFSYVVVFLVCWLPYHVAVLLDIFSILhYIPFTCRL 289
Cdd:cd15185 163 RFHALRMNIFGLALPLLIMVICYTGIIKTLLRCPSKKKYKAIRLIFVIMVVFFIFWTPYNLVLLLSAFQSI-FFETDCER 241
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 31083344 290 EHALFTALHVTQCLSLVHCCVNPVLYSFINRNYRYEL 326
Cdd:cd15185 242 SKHLDLAMQVTEVIAYTHCCINPVIYAFVGERFRKYL 278
7tmA_NPYR-like cd15203
neuropeptide Y receptors and related proteins, member of the class A family of ...
45-326 5.51e-37

neuropeptide Y receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to Gi or Go proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. Also included in this subgroup is prolactin-releasing peptide (PrRP) receptor (previously known as GPR10), which is activated by its endogenous ligand PrRP, a neuropeptide possessing C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acid residues (PrRP-20) and the other consists of 31 amino acid residues (PrRP-31). PrRP receptor shows significant sequence homology to the NPY receptors, and a micromolar level of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors.


Pssm-ID: 320331 [Multi-domain]  Cd Length: 293  Bit Score: 135.04  E-value: 5.51e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  45 YTLSFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWV-VLTIPVWVVSLVQHNqWPMGELTCKVTHLI 123
Cdd:cd15203   1 IILILLYGLIIVLGVVGNLLVIYVVLRNKSMQTVTNIFILNLAVSDLLLcLVSLPFTLIYTLTKN-WPFGSILCKLVPSL 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 124 FSINLFGSIFFLTCMSVDRYLSITYftntPSSRKKMVRRVVCI--LVWLLAFCVSLPDTYYLKTVTSASNNETYCRSFYP 201
Cdd:cd15203  80 QGVSIFVSTLTLTAIAIDRYQLIVY----PTRPRMSKRHALLIiaLIWILSLLLSLPLAIFQELSDVPIEILPYCGYFCT 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 202 EH-SIKEWLIGMELVSVVLGFAVPFSIIAVFYFLLARAI------------SASSDQEKHSSRK-----IIFSYVVVFLV 263
Cdd:cd15203 156 ESwPSSSSRLIYTISVLVLQFVIPLLIISFCYFRISLKLrkrvkkkrgkrtLSSRRRRSELRRKrrtnrLLIAMVVVFAV 235
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 31083344 264 CWLPYHVAVLLDIFSilHYIPFTCRLEHALFTALHvtqCLSLVHCCVNPVLYSFINRNYRYEL 326
Cdd:cd15203 236 CWLPLNLFNLLRDFE--PLPQIDGRHFYLIFLICH---LIAMSSACVNPLLYGWLNDNFRKEF 293
7tmA_CCR5_CCR2 cd15184
CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G ...
50-323 1.24e-36

CC chemokine receptor types 5 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors; CCR2 and CCR5 share very high amino acid sequence identity. Both receptors play important roles in the trafficking of monocytes/macrophages and are implicated in the pathogenesis of immunologic diseases (rheumatoid arthritis, celiac disease, and transplant rejection) and cardiovascular diseases (atherosclerosis and autoimmune hepatitis). CCR2 is a receptor specific for members of the monocyte chemotactic protein family, including CCL2, CCL7, and CCL13. Conversely, CCR5 is a major co-receptor for HIV infection and binds many CC chemokine ligands, including CC chemokine ligands including CCL2, CCL3, CCL4, CCL5, CCL11, CCL13, CCL14, and CCL16. CCR2 is expressed primarily on blood monocytes and memory T cells, whereas CCR5 is expressed on antigen-presenting cells (macrophages and dendritic cells) and activated T effector cells. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341338 [Multi-domain]  Cd Length: 278  Bit Score: 133.73  E-value: 1.24e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  50 IYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVqhNQWPMGELTCKVTHLIFSINLF 129
Cdd:cd15184   6 LYSLVFIFGFVGNMLVVLILINCKKLKSMTDIYLLNLAISDLLFLLTLPFWAHYAA--NEWVFGNAMCKLLTGLYHIGFF 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 130 GSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDTYYLKtvTSASNNETYCRSFYPEHSIKEWL 209
Cdd:cd15184  84 SGIFFIILLTIDRYLAIVHAVFALKARTVTFGVVTSVVTWVVAVFASLPGIIFTK--SQKEGSHYTCSPHFPPSQYQFWK 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 210 IGMELVSVVLGFAVPFSIIAVFYF-LLARAISASSDQEKHSSRKIIFSYVVVFLVCWLPYHVAVLLDIFSILHYIPfTCR 288
Cdd:cd15184 162 NFQTLKMNILGLVLPLLVMIICYSgILKTLLRCRNEKKRHKAVRLIFTIMIVYFLFWAPYNIVLLLNTFQEFFGLN-NCS 240
                       250       260       270
                ....*....|....*....|....*....|....*
gi 31083344 289 LEHALFTALHVTQCLSLVHCCVNPVLYSFINRNYR 323
Cdd:cd15184 241 SSNRLDQAMQVTETLGMTHCCINPVIYAFVGEKFR 275
7tmA_Gal1_R cd15098
galanin receptor subtype 1, member of the class A family of seven-transmembrane G ...
50-323 1.79e-36

galanin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320226 [Multi-domain]  Cd Length: 282  Bit Score: 133.31  E-value: 1.79e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  50 IYIFIFVIGMIANSVVVWVNIQAKTTG--YDTHCYILNLAIADL-WVVLTIPVW--VVSLvqhNQWPMGELTCKVTHLIF 124
Cdd:cd15098   6 VFGLIFCLGVLGNSLVITVLARVKPGKrrSTTNVFILNLSIADLfFLLFCVPFQatIYSL---PEWVFGAFMCKFVHYFF 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 125 SINLFGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDTYYLKTVTSAS-NNETYCrsfYPEH 203
Cdd:cd15098  83 TVSMLVSIFTLVAMSVDRYIAVVHSRTSSSLRTRRNALLGVLVIWVLSLAMASPVAVHQDLVHHWTaSNQTFC---WENW 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 204 SIKEWLIGMELVSVVLGFAVPFSIIAVFYFLL-------ARAISASSDQEKHSSRKIIFSYVVVFLVCWLPYHVAVLLDI 276
Cdd:cd15098 160 PEKQQKPVYVVCTFVFGYLLPLLLITFCYAKVlnhlhkkLKNMSKKSERSKKKTAQTVLVVVVVFGISWLPHHIIHLWVE 239
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 31083344 277 FSILhyiPFTcrleHALFTALHVTQCLSLVHCCVNPVLYSFINRNYR 323
Cdd:cd15098 240 FGDF---PLT----QASFVLRITAHCLAYANSCVNPIIYAFLSENFR 279
7tmA_C3aR cd15115
complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of ...
50-323 2.42e-36

complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The anaphylatoxin receptors are a group of G-protein coupled receptors which bind anaphylatoxins; members of this group include C3a receptors and C5a receptors. Anaphylatoxins are also known as complement peptides (C3a, C4a and C5a) that are produced from the activation of the complement system cascade. These complement anaphylatoxins can trigger degranulation of endothelial cells, mast cells, or phagocytes, which induce a local inflammatory response and stimulate smooth muscle cell contraction, histamine release, and increased vascular permeability. They are potent mediators involved in chemotaxis, inflammation, and generation of cytotoxic oxygen-derived free radicals. In humans, a single receptor for C3a (C3AR1) and two receptors for C5a (C5AR1 and C5AR2, also known as C5L2 or GPR77) have been identified, but there is no known receptor for C4a.


Pssm-ID: 320243 [Multi-domain]  Cd Length: 265  Bit Score: 132.59  E-value: 2.42e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  50 IYIFIFVIGMIANSVVVWV-NIQAKTTGydTHCYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVTHLIFSINL 128
Cdd:cd15115   6 VLSLTFLLGVPGNGLVIWVaGLKMKRTV--NTIWFLNLAVADLLCCLSLPFSIAHLLLNGHWPYGRFLCKLLPSIIVLNM 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 129 FGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDTYYLKTVTsaSNNETYCrsfypehsIKEW 208
Cdd:cd15115  84 FASVFTLTAISLDRFLLVIKPVWAQNHRSVLLACLLCGCIWILALLLCLPVFIYRTTVT--DGNHTRC--------GYDF 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 209 LIGMELVSVVLGFAVPFSIIAVFYFLLARAISASSDQEKHS-SRKIIFSYVVVFLVCWLPYHVAVLLDIFSilhyipfTC 287
Cdd:cd15115 154 LVAITITRAVFGFLLPLLIIAACYSFIAFRMQRGRFAKSQSkTFRVIIAVVVAFFVCWAPYHIIGILSLYG-------DP 226
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 31083344 288 RLEHALFTALHVTQCLSLVHCCVNPVLYSFINRNYR 323
Cdd:cd15115 227 PLSKVLMSWDHLSIALAYANSCLNPVLYVFMGKDFK 262
7tmA_CysLTR cd15921
cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G ...
48-326 4.26e-36

cysteinyl leukotriene receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320587 [Multi-domain]  Cd Length: 283  Bit Score: 132.62  E-value: 4.26e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  48 SFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVTHLIFSIN 127
Cdd:cd15921   4 PTAYILIFILGLTGNSISVYVFLSQYRSQTPVSVLMVNLAISDLLLVCTLPLRLTYYVLNSHWPFGDIACRIILYVLYVN 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 128 LFGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDTYYlktvTSASNNETYCRSFYPEHSIKE 207
Cdd:cd15921  84 MYSSIYFLTALSVFRYLALVWPYLYLRVQTHSVAGIICGLIWILMGLASSPLLFA----KSKQHDEGSTRCLELAHDAVD 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 208 WLIGMELVSVVLGFAVPFSIIAVFYFLLARAISASSDQEKH---SSRKIIFSYVVV---FLVCWLPYHVAVLLDIfSILH 281
Cdd:cd15921 160 KLLLINYVTLPVGFVVPFMTVIFCYIFIIKNLLKPSPALGRtrpSRRKACALIIISlgiFLVCFLPYHIVRTIHL-ITER 238
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 31083344 282 YIPFTCRLEHALFTALHVTQCLSLVHCCVNPVLYSFINRNYRYEL 326
Cdd:cd15921 239 QIKESCGYILRVRKAAVITLCLAASNSCFDPLLYFFVGENFRSRL 283
7tmA_CysLTR1 cd15158
cysteinyl leukotriene receptor 1, member of the class A family of seven-transmembrane G ...
48-326 4.97e-36

cysteinyl leukotriene receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320286 [Multi-domain]  Cd Length: 285  Bit Score: 132.18  E-value: 4.97e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  48 SFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVTHLIFSIN 127
Cdd:cd15158   4 STLYSVITVFGLVGNGFALYVLIKTYRQKSAFHIYMLNLAVSDLLCVCTLPLRVVYYVHKGQWLFGDFLCRISSYALYVN 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 128 LFGSIFFLTCMSVDRYLSITYftntPSSRKKMVR----RVVCILVWLLAFCVSLPdtYYLKTVTSASNNETYCRSFYPEH 203
Cdd:cd15158  84 LYCSIYFMTAMSFTRFLAIVF----PVQNLNLVTvkkaRIVCVGIWIFVTLTSSP--FLMSGSHDTETNKTKCFEPPQSN 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 204 SIKEWLIGMELVSVVLGFAVPFSIIAVFYFLLARAI---SASSDQEKHSSRKIIFSYVVV---FLVCWLPYHVAVLLDIF 277
Cdd:cd15158 158 QQLTKLLVLNYISLVVGFIIPFLVILICYAMIIRTLlknTMKARKQQSSRKKAIRMIIIVllaFLVSFMPYHIQRTIHLH 237
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 31083344 278 SiLHYIPFTCRLEHALFTALHVTQCLSLVHCCVNPVLYSFINRNYRYEL 326
Cdd:cd15158 238 F-LSRKDSTCEEVLYMQKSVVITLCLAAANCCFDPLLYFFSGENFRRRL 285
7tmA_LPAR6_P2Y5 cd15156
lysophosphatidic acid receptor 6, member of the class A family of seven-transmembrane G ...
48-317 6.18e-36

lysophosphatidic acid receptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 6 (LPAR6), also known as P2Y5, is a G(i), G(12/13) G protein-coupled receptor that is activated by the bioactive lipid lysophosphatidic acid (LPA), which is released by activated platelets and constitutively present in serum. LPAR6 plays an important role in maintenance of human hair growth. Thus, mutations in the receptor are responsible for both autosomal recessive wooly hair and hypotrichosis. Phylogenetic analysis of the class A GPCRs shows that LAPR6 (P2Y5) is classified into the cluster consisting of receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production.


Pssm-ID: 320284 [Multi-domain]  Cd Length: 285  Bit Score: 131.90  E-value: 6.18e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  48 SFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVQHNqWPMGELTCKVTHLIFSIN 127
Cdd:cd15156   4 GCVFSMVFVLGLIANCVAIYIFMCTLKVRNETTTYMINLAISDLLFVFTLPFRIFYFVQRN-WPFGDLLCKISVTLFYTN 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 128 LFGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDTYYLKTVTSASNNETYCRSFYPEHSIKE 207
Cdd:cd15156  83 MYGSILFLTCISVDRFLAIVYPFRSKTLRTKRNAKIVCAAVWLTVLAGSLPASFFQSTNNQLNNNSETCFENFSSKTWKT 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 208 WLIGMELVSVVLGFAVPFSI----IAVFYFLLARAISASSDQ-EKHSSRKIIFSYVVVFLVCWLPYHVAVLLdiFSILHY 282
Cdd:cd15156 163 YLSKIVIFIEIVGFFIPLILnvtcSTMVLKTLRRPNTLSRSKlNKKKVLKMIFVHLFIFCFCFIPYNVNLVL--YSLVRT 240
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 31083344 283 IPFT-CRLEHALFTALHVTQCLSLVHCCVNPVLYSF 317
Cdd:cd15156 241 QTFKnCSVVAAVRTMYPITLCIAVSNCCFDPIVYYF 276
7tmA_FPR-like cd15117
N-formyl peptide receptors, member of the class A family of seven-transmembrane G ...
50-326 2.19e-35

N-formyl peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed at elevated levels on polymorphonuclear and mononuclear phagocytes. FPRs bind N-formyl peptides, which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Activation of FPRs by N-formyl peptides such as N-formyl-Met-Leu-Phe (FMLP) triggers a signaling cascade that stimulates neutrophil accumulation, phagocytosis and superoxide production. These responses are mediated through a pertussis toxin-sensitive G(i) protein that activates a PLC-IP3-calcium signaling pathway. While FPRs are involved in host defense responses to bacterial infection, they can also suppress the immune system under certain conditions. Yet, the physiological role of the FPR family is not fully understood.


Pssm-ID: 320245 [Multi-domain]  Cd Length: 288  Bit Score: 130.62  E-value: 2.19e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  50 IYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYiLNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVTHLIFSINLF 129
Cdd:cd15117   6 IYSSAFVLGTLGNGLVIWVTGFRMTRTVTTVCF-LNLAVADFAFCLFLPFSVVYTALGFHWPFGWFLCKLYSTLVVFNLF 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 130 GSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDTYYLKTVTsaSNNETYCRSFY--PEHSIKE 207
Cdd:cd15117  85 ASVFLLTLISLDRCVSVLWPVWARNHRTPARAALVAVGAWLLALALSGPHLVFRDTRK--ENGCTHCYLNFdpWNETAED 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 208 WLIGMELVS----------VVLGFAVPFSIIAVFYFLLARAIsaSSDQEKHSSR--KIIFSYVVVFLVCWLPYHVAVLLD 275
Cdd:cd15117 163 PVLWLETVVqrlsaqvitrFVLGFLVPLVIIGGCYGLIAARL--WREGWVHSSRpfRVLTAVVAAFFLCWFPFHLVSLLE 240
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 31083344 276 IFSILHYIPftcRLEHALFTALHVTQCLSLVHCCVNPVLYSFINRNYRYEL 326
Cdd:cd15117 241 LVVILNQKE---DLNPLLILLLPLSSSLACVNSCLNPLLYVFVGRDFRERL 288
7tmA_Bradykinin_R cd15189
bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
51-323 2.44e-35

bradykinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320317 [Multi-domain]  Cd Length: 284  Bit Score: 130.28  E-value: 2.44e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  51 YIF-IFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVTHLIFSINLF 129
Cdd:cd15189   6 FIFsLCLFGLLGNLFVLLVFLLHRRRLTVAEIYLGNLAAADLVFVSGLPFWAMNILNQFNWPFGELLCRVVNGVIKVNLY 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 130 GSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDTYYLKTVTSASNNETYCRSFYPEHSikeWL 209
Cdd:cd15189  86 TSIYLLVMISQDRYLALVKTMAARRLRRRRYAKLICVLIWVVGLLLSIPTFLLRKIKAIPDLNITACVLLYPHEA---WH 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 210 IGMELVSVVLGFAVPFSIIAVFYFLLARAISASSDQEKHSSRK------IIFSYVVVFLVCWLPYHVAVLLDIFSILHYI 283
Cdd:cd15189 163 FAHIVLLNIVGFLLPLLVITFCNYNILQALRTREESTRCEDRNdskataLVLAVTLLFLVCWGPYHFFTFLDFLFDVGVL 242
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 31083344 284 PfTCRLEHALFTALHVTQCLSLVHCCVNPVLYSFINRNYR 323
Cdd:cd15189 243 D-ECFWEHFIDIGLQLAVFLAFSNSCLNPVLYVFVGRYFR 281
7tmA_SSTR4 cd15973
somatostatin receptor type 4, member of the class A family of seven-transmembrane G ...
47-323 6.12e-35

somatostatin receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR4 plays a critical role in mediating inflammation. Unlike other SSTRs, SSTR4 subtype is not detected in all pituitary adenomas while it is expressed in the normal human pituitary.


Pssm-ID: 320639 [Multi-domain]  Cd Length: 274  Bit Score: 129.21  E-value: 6.12e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  47 LSFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVQHnQWPMGELTCKVTHLIFSI 126
Cdd:cd15973   3 IQFIYALVCLVGLIGNSMVIFVILRYAKMKTATNIYILNLAIADELFMLSVPFLAASAALQ-HWPFGSAMCRTVLSVDGI 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 127 NLFGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDTYYLKTVTSaSNNETYCRSFYPEHSik 206
Cdd:cd15973  82 NMFTSVFCLTVLSVDRYIAVVHPLRAARYRRPTVAKMINICVWILSLLVISPIIIFADTATR-KGQAVACNLIWPHPA-- 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 207 eWLIGMELVSVVLGFAVPFSIIAVFYFLL-----ARAISASSDQEKHSSRKI---IFSYVVVFLVCWLPYHVAVLLDIFs 278
Cdd:cd15973 159 -WSAAFVIYTFLLGFLLPVLAIGLCYILIigkmrAVALKAGWQQRRKSEKKItrmVLMVVTVFVICWMPFYVVQLLNLF- 236
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 31083344 279 ilhyipftcrLEHALFTALHVTQCLSLVHCCVNPVLYSFINRNYR 323
Cdd:cd15973 237 ----------LPRLDATVNHASLILSYANSCANPILYGFLSDNFR 271
7tmA_Kappa_opioid_R cd15091
opioid receptor subtype kappa, member of the class A family of seven-transmembrane G ...
47-323 2.08e-34

opioid receptor subtype kappa, member of the class A family of seven-transmembrane G protein-coupled receptors; The kappa-opioid receptor binds the opioid peptide dynorphin as the primary endogenous ligand. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320219 [Multi-domain]  Cd Length: 282  Bit Score: 127.76  E-value: 2.08e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  47 LSFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVQhNQWPMGELTCKVTHLIFSI 126
Cdd:cd15091   3 ITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLM-NSWPFGDVLCKIVISIDYY 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 127 NLFGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDTYYLKTVTSASNNETYCRSFYPEHSIK 206
Cdd:cd15091  82 NMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDSTECSLQFPDDDYS 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 207 EWLIGMELVSVVLGFAVPFSIIAVFYFLL------ARAISASSDQEKHSSR--KIIFSYVVVFLVCWLPYHVAVLLD-IF 277
Cdd:cd15091 162 WWDTFMKICVFIFAFVIPVLIIIVCYTLMilrlksVRLLSGSREKDRNLRRitRLVLVVVAVFVVCWTPIHIFILVEaLG 241
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 31083344 278 SILHYIpftcrlehALFTALHVTQCLSLVHCCVNPVLYSFINRNYR 323
Cdd:cd15091 242 SVSHST--------AAVSSYYFCIALGYTNSSLNPILYAFLDENFK 279
7tmA_P2Y1 cd15377
P2Y purinoceptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
45-326 2.73e-34

P2Y purinoceptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y1 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. This family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 341350 [Multi-domain]  Cd Length: 289  Bit Score: 127.72  E-value: 2.73e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  45 YTLSFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVTHLIF 124
Cdd:cd15377   1 YYLPAVYILVFITGFLGNSVAIWMFVFHMKPWSGISVYMFNLALADFLYVLTLPALIFYYFNKTDWIFGDAMCKLQRFIF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 125 SINLFGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDTYYLKTVTSaSNNETYCRSFYPEHS 204
Cdd:cd15377  81 HVNLYGSILFLTCISVHRYTGVVHPLKSLGRLKKKNAICISVLVWLIVVVAISPILFYSGTGVR-KNKTITCYDTTSDEY 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 205 IKEWLIgMELVSVVLGFAVPFSIIAVFYFLLARAI-----SASSDQEKHSSRKIIFSYVV---VFLVCWLPYHVAVLLDI 276
Cdd:cd15377 160 LRSYFI-YSMCTTVAMFCVPFILILGCYGLIVRALiykdmKYTEENNAPLRRKSIYLVIIvltVFAVSYLPFHVMKTLNL 238
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 31083344 277 FSILHY-IPFTCRLEHALFTALHVTQCLSLVHCCVNPVLYSFINRNYRYEL 326
Cdd:cd15377 239 RARLDFqTPAMCAFNDRVYATYQVTRGLASLNSCVDPILYFLAGDTFRRRL 289
7tmA_LTB4R2 cd15122
leukotriene B4 receptor subtype 2 (LTB4R2 or BLT2), member of the class A family of ...
57-317 3.32e-34

leukotriene B4 receptor subtype 2 (LTB4R2 or BLT2), member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the Gq-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320250 [Multi-domain]  Cd Length: 281  Bit Score: 127.23  E-value: 3.32e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  57 IGMIANSVVVWvNIQAKTTGYD---THCYILNLAIADLWVVLTIPVWVVSLVQHNqWPMGELTCKVTHLIFSINLFGSIF 133
Cdd:cd15122  13 LGLPGNGFIIW-SILWKMKARGrsvTCILILNLAVADGAVLLLTPFFITFLTRKT-WPFGQAVCKAVYYLCCLSMYASIF 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 134 FLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDTYYLKTVTSASNNETYCRSFYPEHSIKEWLIGME 213
Cdd:cd15122  91 IIGLMSLDRCLAVTRPYLAQSLRKKALVRKILLAIWLLALLLALPAFVYRHVWKDEGMNDRICEPCHASRGHAIFHYTFE 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 214 lvsVVLGFAVPFSIIAVFYFLLARAISASSDQEKHSSRKIIFSYVVVFLVCWLPYHVAVLLDIFSILHYIPFTCRLEHAL 293
Cdd:cd15122 171 ---TLVAFVLPFGVILFSYSVILVRLKGARFRRRARVEKLIAAIVVAFALLWVPYHVVNLLQVVANLAPGEVLEKLGGAA 247
                       250       260
                ....*....|....*....|....
gi 31083344 294 FTALHVTQCLSLVHCCVNPVLYSF 317
Cdd:cd15122 248 KAARAGATALAFFSSSVNPLLYVF 271
7tmA_P2Y-like cd15922
P2Y purinoceptor-like proteins, member of the class A family of seven-transmembrane G ...
52-323 6.30e-34

P2Y purinoceptor-like proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y-like proteins are an uncharacterized group that is phylogenetically related to a family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320588 [Multi-domain]  Cd Length: 284  Bit Score: 126.75  E-value: 6.30e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  52 IFIFVIGMIANSVVVWV---NIQAKTTGYdthcyIL--NLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVTHLIFSI 126
Cdd:cd15922   8 SLVFLGGFLLNSFSLWIfwfRIKQWSSGT-----ILqfNLALSDAIITPAAPLLIAYFSLGSHWPFGQFLCQLKVFLLST 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 127 NLFGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDTYYLKtvTSASNNETYCRSFYpEHSIK 206
Cdd:cd15922  83 HMYGSIYFLMLISIHRYVTVVHYNWKSLWKKKSFMKKLCLGVWLLLFVQGLPFFFVLK--TSVIDGKTKCLSIH-QSELS 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 207 EWLIGMELVSVVLGFAVPFSIIAVFYFLLARAIS------ASSDQEKHSSRKIIFSYVVVFLVCWLPYHVAVLLDIFSIL 280
Cdd:cd15922 160 LLYFVWNFVLLILGFLLPFGVSLTCYALLGASIAkmnsnnARGRAMKAKSLQMIGISLVIFIICFVPLHVTRTVGVVVKL 239
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 31083344 281 HYiPFTCRLEHALFTALHVTQCLSLVHCCVNPVLYSFINRNYR 323
Cdd:cd15922 240 FY-PESCTLLHKVEVAYYISWVLTGVNCCLDPLLYCFASEKFR 281
7tmA_CCKR-like cd14993
cholecystokinin receptors and related proteins, member of the class A family of ...
45-323 8.93e-34

cholecystokinin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents four G-protein coupled receptors that are members of the RFamide receptor family, including cholecystokinin receptors (CCK-AR and CCK-BR), orexin receptors (OXR), neuropeptide FF receptors (NPFFR), and pyroglutamylated RFamide peptide receptor (QRFPR). These RFamide receptors are activated by their endogenous peptide ligands that share a common C-terminal arginine (R) and an amidated phenylanine (F) motif. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors. Orexins (OXs; also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. The 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103. Neuropeptide FF (NPFF) is a mammalian octapeptide that has been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of NPFF are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R.


Pssm-ID: 320124 [Multi-domain]  Cd Length: 296  Bit Score: 126.56  E-value: 8.93e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  45 YTLSFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLT-IPVWVVSLVQHNqWPMGELTCKVTHLI 123
Cdd:cd14993   1 IVLIVLYVVVFLLALVGNSLVIAVVLRNKHMRTVTNYFLVNLAVADLLVSLFcMPLTLLENVYRP-WVFGEVLCKAVPYL 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 124 FSINLFGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDTYYLKTVTSASNNE-----TYCRS 198
Cdd:cd14993  80 QGVSVSASVLTLVAISIDRYLAICYPLKARRVSTKRRARIIIVAIWVIAIIIMLPLLVVYELEEIISSEPgtitiYICTE 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 199 FYPEHSIKEWLIgmeLVSVVLGFAVPFSIIAVFYFLLAR----------AISASSDQEKHSSR------KIIFSYVVVFL 262
Cdd:cd14993 160 DWPSPELRKAYN---VALFVVLYVLPLLIISVAYSLIGRrlwrrkppgdRGSANSTSSRRILRskkkvaRMLIVVVVLFA 236
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 31083344 263 VCWLPYHVAVLLDIFSilhyiPFTCRLEHALFTALH-VTQCLSLVHCCVNPVLYSFINRNYR 323
Cdd:cd14993 237 LSWLPYYVLSILLDFG-----PLSSEESDENFLLILpFAQLLGYSNSAINPIIYCFMSKKFR 293
7tmA_BK-2 cd15381
bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled ...
46-323 9.57e-34

bradykinin receptor B2, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320503 [Multi-domain]  Cd Length: 284  Bit Score: 126.04  E-value: 9.57e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  46 TLSFIYIF-IFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVTHLIF 124
Cdd:cd15381   1 TFQPIYLWiIFVLGTIENAFVLIVFCLHKSSCTVAEIYLGNLAAADLLLVCCLPFWAINISNGFNWPFGEFLCKSVNAVI 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 125 SINLFGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDTYYLKTVTSASNNETYCRSFYPEHS 204
Cdd:cd15381  81 YMNLYSSIYFLMMVSIDRYLALVKTMSSGRMRRPACAKLNCLIIWMFGLLMSTPMIVFRTVMYFPEYNITACVLDYPSEG 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 205 ikeWLIGMELVSVVLGFAVPFSIIAVFYFLLARAISASSDQE------KHSSRKIIFSYVVVFLVCWLPYHVAVLLDIFS 278
Cdd:cd15381 161 ---WHVALNILLNVVGFLIPLSIITFCSTQIIQVLRNNKMQKfkeiqtERKATVLVLAVLLMFFICWLPFHIFTFLDTLH 237
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 31083344 279 ILHYIPfTCRLEHALFTALHVTQCLSLVHCCVNPVLYSFINRNYR 323
Cdd:cd15381 238 KLGLIS-GCRWEDILDIGTQIATFLAYSNSCLNPLLYVIVGKHFR 281
7tmA_Galanin_R-like cd14971
galanin receptor and related proteins, member of the class A family of seven-transmembrane G ...
45-323 1.04e-33

galanin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled galanin receptors, kisspeptin receptor and allatostatin-A receptor (AstA-R) in insects. These receptors, which are members of the class A of seven transmembrane GPCRs, share a high degree of sequence homology among themselves. The galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, eating disorders, and epilepsy, among many others. KiSS1-derived peptide receptor (also known as GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. AstA-R is a G-protein coupled receptor that binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320102 [Multi-domain]  Cd Length: 281  Bit Score: 126.04  E-value: 1.04e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  45 YTLSFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVTHLIF 124
Cdd:cd14971   1 WIVPLFFALIFLLGLVGNSLVILVVARNKPMRSTTNLFILNLAVADLTFLLFCVPFTATIYPLPGWVFGDFMCKFVHYFQ 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 125 SINLFGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDTYYLKTVTSASNNETYCRSFYPEHS 204
Cdd:cd14971  81 QVSMHASIFTLVAMSLDRFLAVVYPLRSLHIRTPRNALAASGCIWVVSLAVAAPVLALHRLRNYTPGNRTVCSEAWPSRA 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 205 IKEwliGMELVSVVLGFAVPFSIIAVFYFLLAR---------AISASSDQEKHSSRKIIFSYVVVFLVCWLPYHVAVLLD 275
Cdd:cd14971 161 HRR---AFALCTFLFGYLLPLLLICVCYAAMLRhlwrvavrpVLSEGSRRAKRKVTRLVLVVVVLFAACWGPIHAILLLV 237
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 31083344 276 IFSILHYIPFTcrlehalFTALHVTQCLSLVHCCVNPVLYSFINRNYR 323
Cdd:cd14971 238 ALGPFPLTYAT-------YALRIWAHCLAYSNSAVNPVLYAFLSEHFR 278
7tmA_LTB4R1 cd15121
leukotriene B4 receptor subtype 1 (LTB4R1 or BLT1), member of the class A family of ...
55-317 1.43e-33

leukotriene B4 receptor subtype 1 (LTB4R1 or BLT1), member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the Gq-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320249 [Multi-domain]  Cd Length: 278  Bit Score: 125.70  E-value: 1.43e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  55 FVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVQHNqWPMGELTCKVTHLIFSINLFGSIFF 134
Cdd:cd15121  11 FILGFPGNLFVVWSVLCRMKKRSVTCILVLNLALADAAVLLTAPFFLHFLSGGG-WEFGSVVCKLCHYVCGVSMYASIFL 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 135 LTCMSVDRYLSITY-FTNTPSSRKKMVRRVVcILVWLLAFCVSLPDTYYlKTVTSASNNETYCrsfYPEHSIKEWLIGME 213
Cdd:cd15121  90 ITLMSMDRCLAVAKpFLSQKMRTKRSVRALL-LAIWIVAFLLSLPMPFY-RTVLKKNINMKLC---IPYHPSVGHEAFQY 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 214 LVSVVLGFAVPFSIIAVFYFLLARAISASSDQEKHSSRKIIFSYVVVFLVCWLPYHVAVLLDIFSILHYIPFTCRLEHAL 293
Cdd:cd15121 165 LFETITGFLLPFTAIVTCYSTIGRRLRSARFRRKRRTNRLVVLIIATFALFWLPYHVVNLIQVAGALQNQAGNASVLKAA 244
                       250       260
                ....*....|....*....|....
gi 31083344 294 FTALHVTQCLSLVHCCVNPVLYSF 317
Cdd:cd15121 245 KLARPNVTALAFLSSSVNPVLYAF 268
7tmA_P2Y1-like cd15967
P2Y purinoceptor 1-like; P2Y1-like is an uncharacterized group that is phylogenetically ...
50-321 1.44e-33

P2Y purinoceptor 1-like; P2Y1-like is an uncharacterized group that is phylogenetically related to a family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320633 [Multi-domain]  Cd Length: 281  Bit Score: 125.57  E-value: 1.44e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  50 IYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVTHLIFSINLF 129
Cdd:cd15967   6 VYILVFVVGLVGNVWGLKSLLANWKKLGNINVFVLNLGLADLLYLLTLPFLVVYYLKGRKWIFGQVFCKITRFCFNLNLY 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 130 GSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDTYYLKTvtsaSNNETYCRSFYPEHSIKEWL 209
Cdd:cd15967  86 GSIGFLTCISVYRYLAIVHPMRVMGRITTTHSVVISALVWLLVVIQSLPDLFFSKT----NSNGTKCFDTTFNDYLESYL 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 210 iGMELVSVVLGFAVPFSIIAVFYFLLARAISASSDQE---KHSSRKIIFSYVVVFLVCWLPYHVAVLLDIFSILHYIPFT 286
Cdd:cd15967 162 -TYSLGWTVTGFVIPLLIILGCYGHVVVVLCRNNNVDkglKQRCLKLVIILIVLFSVCYIPYHVFRNLNLLSRILQKQGS 240
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 31083344 287 C-RLEHALFTALHVTQCLSLVHCCVNPVLYSFINRN 321
Cdd:cd15967 241 CtQWFRGIYIAHQVSRGLVCLNSALNPLVYLMGSED 276
7tmA_GPR132_G2A cd15364
proton-sensing G protein-coupled receptor 132, member of the class A family of ...
47-326 1.60e-33

proton-sensing G protein-coupled receptor 132, member of the class A family of seven-transmembrane G protein-coupled receptors; The G2 accumulation receptor (G2A, also known as GPR132) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the T cell death associated gene-8 (TDAG8, GPR65) receptor, ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. G2A was originally identified as a stress-inducible receptor that causes the cell cycle arrest at G2/M phase when serum is deprived. Lysophosphatidylcholine was identified as a ligand for G2A, and whose overexpression was shown to induce cell proliferation, oncogenic transformation, and apoptosis.


Pssm-ID: 320486 [Multi-domain]  Cd Length: 279  Bit Score: 125.66  E-value: 1.60e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  47 LSFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVTHLIFSI 126
Cdd:cd15364   3 LVVVYSVVFALGFPANCLTLWLTLLQVRRKNVLAVYLFSLSLCELLYLGTLPLWTIYVSNNHKWPWGSLACKITGYIFFC 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 127 NLFGSIFFLTCMSVDRYLSITYFTNTPSSRKkmvRRVVCILVWLLAFCVSLPDTYYLKTVTSASNNETYCRSFYPEHSIk 206
Cdd:cd15364  83 NIYISILLLCCISIDRFVAVVYALESRGRRR---QRIAAFISFLIFIVVGLVHSPVFIMREGQTEGSHTCFETLQMDTQ- 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 207 ewLIGMELVSVVLGFAVPFSIIAVFYFLLARAISASSDQEKHSSRKIIFS---YVVVFLVCWLPYHVAVLLDIFSILHYI 283
Cdd:cd15364 159 --VAGFYYARFCIGFAIPLAILIFTNYRIFRSIQTSTSLTPHQKAKVKYLaiaVIVIFLICFAPYHLVLLVRAIAFSLYP 236
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 31083344 284 PFTCRLEHALFTALHVTQCLSLVHCCVNPVLYSFINRNYRYEL 326
Cdd:cd15364 237 NGMCGFEERIYTPSVIFLCLSTVNSVADPIIYVLVSENVRQDI 279
7tmA_GPR1 cd15119
G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane ...
50-326 2.75e-33

G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 1 (GPR1) belongs to the class A of the seven transmembrane domain receptors. This is an orphan receptor that can be activated by the leukocyte chemoattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1. GPR1 is most closely related to another chemerin receptor CMKLR1. In an in-vitro study, GPR1 has been shown to act as a co-receptor to allow replication of HIV viruses.


Pssm-ID: 320247 [Multi-domain]  Cd Length: 278  Bit Score: 124.86  E-value: 2.75e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  50 IYIFIFVIGMIANSVVVWVniqaktTGYD-----THCYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVTHLIF 124
Cdd:cd15119   6 IYIVAFVLGVPGNAIVIWV------TGFKwkktvNTLWFLNLAIADFVFVLFLPLHITYVALDFHWPFGVWLCKINSFVA 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 125 SINLFGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDTYYLKTVTsASNNETYCRSFYPEHS 204
Cdd:cd15119  80 VLNMFASVLFLTVISLDRYISLAHPVWSHRYRTLKSALILCGIVWLSAAAISGPALYFRDTME-LSINVTICFNNFHKHD 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 205 ---IKEWLIGMELVSVVLGFAVPFSIIAVFYFLLARAISASSDQEKHSSRKIIFSYVVVFLVCWLPYHvavlldIFSILH 281
Cdd:cd15119 159 gdlIVMRHTILVWVRFFFGFLFPLLTMVVCYSLLAIKVKRRTLLISSKFFWTISAVIVAFFVCWTPYH------IFSILE 232
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 31083344 282 Y-IPFTCRLEHALFTALHVTQCLSLVHCCVNPVLYSFINRNYRYEL 326
Cdd:cd15119 233 LsIHHSSYLHNVLRAGIPLATSLAFINSCLNPILYVLIGKKFKAHL 278
7tmA_RNL3R1 cd15926
relaxin 3 receptor 1 (RNL3R1), member of the class A family of seven-transmembrane G ...
47-326 3.77e-33

relaxin 3 receptor 1 (RNL3R1), member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled receptor RNL3R1 is also known as GPCR135, relaxin family peptide receptor 3 (RXFP3), and somatostatin- and angiotensin-like peptide receptor (SALPR). RNL3/relaxin-3, a member of the insulin superfamily, is an endogenous neuropeptide ligand for RNL3R1. RNL3R1 is predominantly expressed in brain regions and implicated in stress, anxiety, and feeding, and metabolism. RNL3R1 signals through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation, and also activates Erk1/2 signaling pathway.


Pssm-ID: 320592 [Multi-domain]  Cd Length: 288  Bit Score: 124.62  E-value: 3.77e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  47 LSFIYIFIFVIGMIANSVVVWV-NIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVTHLIFS 125
Cdd:cd15926   3 ISIVYSVVCALGLVGNLLVLYLmKSKQGWKKSSINLFVTSLAVTDFQFVLTLPFWAVENALDFTWLFGKAMCKIVSYVTA 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 126 INLFGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDTYYLKTVTSAsnNETYCRSFYPEHSI 205
Cdd:cd15926  83 MNMYASVFFLTAMSVARYHSVASALKSKRRRGCCSAKWLCVLIWVLAILASLPNAIFSTTATVS--NEELCLVKFPDNRG 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 206 KE--WLIGMELVSVVLGFAVPFSIIAVFYFLLARAI-----SASSDQEKHSSRKIIFSYVVVFLVCWLPYHVAVLLDIFS 278
Cdd:cd15926 161 NAqfWLGLYHAQKVLLGFLIPLGIISLCYLLLVRFItdkniTGSSTKRRSKVTKSVTIVVLSFFLCWLPNQALTTWGILI 240
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 31083344 279 ILHYIPFTCRLEHALFTALHVTQCLSLVHCCVNPVLYSFINRNYRYEL 326
Cdd:cd15926 241 KLNVVHFSYEYFTTQVYIFPITVCLAHSNSCLNPILYCLMRREFRKAL 288
7tmA_P2Y6_P2Y3-like cd15968
P2Y purinoceptors 6 and 3, and similar proteins, member of the class A family of ...
47-317 5.80e-33

P2Y purinoceptors 6 and 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes P2Y receptor 6 (P2Y6), P2Y3, and P2Y3-like proteins. These receptors belong to the G(i) class of a family of purinergic G-protein coupled receptors. In the CNS, P2Y6 plays a role in microglia activation and phagocytosis, and is involved in the secretion of interleukin from monocytes and macrophages in the immune system. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320634 [Multi-domain]  Cd Length: 285  Bit Score: 124.12  E-value: 5.80e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  47 LSFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVTHLIFSI 126
Cdd:cd15968   3 LPICYSFVFLLGLPLNSVVLTRCCRHTKAWTRTAIYMVNLALADLLYALSLPLLIYNYAMRDRWLFGDFMCRLVRFLFYF 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 127 NLFGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDTYYLKtvTSASNNETYCRSF-YPEHSI 205
Cdd:cd15968  83 NLYGSILFLTCISVHRYLGICHPMRPWHKETRRAAWLTCVLVWILVFAQTLPILIFAR--TGIIRNRTVCYDLaPPALFP 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 206 KEWLIGMELvsVVLGFAVPFSIIAVFYFLLARAI-------SASSDQEKHSSRKIIFSYVVVFLVCWLPYHVAvlLDIFS 278
Cdd:cd15968 161 HYVPYGMAL--TVSGFLLPFSIILWCYCLVVRTLcrtlgpaEPPAQARRRKSIRTIVTVTLLFALCFLPFHIT--RTIYL 236
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 31083344 279 ILHYIP-FTCRLEHALFTALHVTQCLSLVHCCVNPVLYSF 317
Cdd:cd15968 237 AVRVTPgVPCHVLEAVAACYKITRPLASANSVLNPLLYFL 276
7tmA_NPFFR cd15207
neuropeptide FF receptors, member of the class A family of seven-transmembrane G ...
51-323 2.33e-32

neuropeptide FF receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320335 [Multi-domain]  Cd Length: 291  Bit Score: 122.73  E-value: 2.33e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  51 YIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWV-VLTIPVwvvSLVQH--NQWPMGELTCKVTHLIFSIN 127
Cdd:cd15207   7 YSLIFLLCVVGNVLVCLVVAKNPRMRTVTNYFILNLAVSDLLVgVFCMPF---TLVDNilTGWPFGDVMCKLSPLVQGVS 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 128 LFGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVrrVVCILVWLLAFCVSLPDTYYLKTVTSASNNE---TYCRSFYPEhs 204
Cdd:cd15207  84 VAASVFTLVAIAVDRYRAVVHPTEPKLTNRQAF--VIIVAIWVLALAIMIPQALVLEVKEYQFFRGqtvHICVEFWPS-- 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 205 iKEWLIGMELVSVVLGFAVPFSIIAVFYFLLARAI---------SASSDQEKHSSR------KIIFSYVVVFLVCWLPYH 269
Cdd:cd15207 160 -DEYRKAYTTSLFVLCYVAPLLIIAVLYVRIGYRLwfkpvpgggSASREAQAAVSKkkvrviKMLIVVVVLFALSWLPLH 238
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 31083344 270 VAVLLDIFS---------ILHYI-PftcrlehalftalhVTQCLSLVHCCVNPVLYSFINRNYR 323
Cdd:cd15207 239 TVTMLDDFGnlspnqrevLYVYIyP--------------IAHWLAYFNSCVNPIVYGYFNRNFR 288
7tmA_OXGR1 cd15375
2-oxoglutarate receptor 1, member of the class A family of seven-transmembrane G ...
45-323 3.10e-32

2-oxoglutarate receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; 2-oxoglutarate receptor 1 (OXGR1) is also known as GPR80, GPR99, or P2Y15. OXGR1 functions as a receptor for alpha-ketoglutarate, a citric acid cycle intermediate, and acts exclusively through a G(q)-dependent pathway. OXGR1 belongs to the class A GPCR superfamily and is phylogenetically related to the purinergic P2Y1-like receptor subfamily, whose members are coupled to G(q) protein to activate phospholipase C (PLC). OXGR1 has also been reported as a potential third cysteinyl leukotriene receptor with specificity for leukotriene E4.


Pssm-ID: 320497 [Multi-domain]  Cd Length: 280  Bit Score: 122.11  E-value: 3.10e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  45 YTLSFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVTHLIF 124
Cdd:cd15375   1 YYLPVMYSIIFIVGFPGNIIAIFVYLFKMRPWKSSTIIMLNLALTDLLYVTSLPFLIYYYINGESWIFGEFMCKFIRFIF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 125 SINLFGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDTYYLKTVTsaSNNETYCRSFYPEHS 204
Cdd:cd15375  81 HFNLYGSILFLTCFSIFRYVVIVHPLRAFQVQKRRWAIVACAVVWVISLAEVSPMTFLITTKE--KNNRTICLDFTSSDN 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 205 IkEWLIGMELVSVVLGFAVPFSIIAVFYFLLARAISA---SSDQEKHSSRKIIFSYVVVFLVCWLPYHVAVLLDIFSILH 281
Cdd:cd15375 159 L-NTIWWYNWILTVLGFLLPLVIVTLCYTRIIYTLAKgphTGSASKQKARRLIILILLVFYVCFLPFHILRVVRIETRLP 237
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 31083344 282 YIpfTCRLEHALFTALHVTQCLSLVHCCVNPVLYSFINRNYR 323
Cdd:cd15375 238 PV--SCCLKHQVHAIYIITRPLAALNTFGNLLLYVVSGDNFQ 277
7tmA_NPBWR cd15087
neuropeptide B/W receptors, member of the class A family of seven-transmembrane G ...
47-326 8.47e-32

neuropeptide B/W receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide B/W receptor 1 and 2 are members of the class A G-protein coupled receptors that bind the neuropeptides B and W, respectively. NPBWR1 (previously known as GPR7) is expressed predominantly in cerebellum and frontal cortex, while NPBWR2 (previously known as GPR8) is located mostly in the frontal cortex and is present in human, but not in rat and mice. These receptors are suggested to be involved in the regulation of food intake, neuroendocrine function, and modulation of inflammatory pain, among many others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320215 [Multi-domain]  Cd Length: 282  Bit Score: 121.00  E-value: 8.47e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  47 LSFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVQHnQWPMGELTCKVTHLIFSI 126
Cdd:cd15087   3 LPVIYSVICAVGLTGNTAVIYVILRAPKMKTVTNVFILNLAIADDLFTLVLPINIAEHLLQ-QWPFGELLCKLILSIDHY 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 127 NLFGSIFFLTCMSVDRYLSI--TYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDTYYLKtVTSASNNETYCRSFYPeHS 204
Cdd:cd15087  82 NIFSSIYFLTVMSVDRYLVVlaTVRSRRMPYRTYRAAKIVSLCVWLLVTIIVLPFTVFAG-VYSNELGRKSCVLSFP-SP 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 205 IKEWLIGMELVSVVLGFAVPFSIIAVFYFLLARAISASS--------DQEKHSSRKIIFSYVVVFLVCWLPYHVAVLLDI 276
Cdd:cd15087 160 ESLWFKASRIYTLVLGFAIPVSTICILYTMMLYKLRNMRlnsnakalDKAKKKVTLMVLVVLAVCLFCWTPFHLSTVVAL 239
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 31083344 277 FSILHYIPFTCRLEHALftalhvtQCLSLVHCCVNPVLYSFINRNYRYEL 326
Cdd:cd15087 240 TTDLPQTPLVIGISYFI-------TSLSYANSCLNPFLYAFLDDSFRKSF 282
7tmA_GPR15 cd15194
G protein-coupled receptor 15, member of the class A family of seven-transmembrane G ...
47-323 1.11e-31

G protein-coupled receptor 15, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR15, also called as Brother of Bonzo (BOB), is an orphan G-protein coupled receptor that was originally identified as a co-receptor for human immunodeficiency virus. GPR15 is upregulated in patients with rheumatoid arthritis and shares high sequence homology with angiotensin II type AT1 and AT2 receptors; however, its endogenous ligand is unknown. GPR15 controls homing of T cells, especially FOXP3(+) regulatory T cells, to the large intestine mucosa and thereby mediates local immune homeostasis. Moreover, GRP15-deficient mice were shown to be prone to develop more severe large intestine inflammation.


Pssm-ID: 320322 [Multi-domain]  Cd Length: 281  Bit Score: 120.73  E-value: 1.11e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  47 LSFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVTHLIFSI 126
Cdd:cd15194   3 LPILYCLVFLVGAVGNAILMGALVFKRGVRRLIDIFISNLAASDFIFLVTLPLWVDKEVVLGPWRSGSFLCKGSSYIISV 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 127 NLFGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPdtYYLKTVTSASNNETYCRSFYPEHSIK 206
Cdd:cd15194  83 NMYCSVFLLTCMSLDRYLAIVLPLVSRKFRTKHNAKVCCTCVWMLSCLLGLP--TLLSRELKKYEEKEYCNEDAGTPSKV 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 207 EWligmELVSVVLGFAVPFSIIAVFYFLLARAI------SASSDQEKHSSRKIIFSYVVVFLVCWLPYHVAVLLDIFSIL 280
Cdd:cd15194 161 IF----SLVSLIVAFFLPLLSILTCYCTIIWKLchhyqkSGKHQKKLRKSIKIVFIVVAAFVFSWMPFNLFKALAIASGL 236
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 31083344 281 HyIPFTCRLEHALFTALHVTQCLSLVHCCVNPVLYSFINRNYR 323
Cdd:cd15194 237 Q-VEVTCLPYTLAQLGMEVSAPLAFANSCANPFIYYFFDRYIR 278
7tmA_Bombesin_R-like cd15927
bombesin receptor subfamily, member of the class A family of seven-transmembrane G ...
45-323 1.14e-31

bombesin receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; This bombesin subfamily of G-protein coupled receptors consists of neuromedin B receptor (NMBR), gastrin-releasing peptide receptor (GRPR), and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple mainly to the G proteins of G(q/11) family. NMBR functions as the receptor for the neuropeptide neuromedin B, a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. Gastrin-releasing peptide is an endogenous ligand for GRPR and shares high sequence homology with NMB in the C-terminal region. Both NMB and GRP possess bombesin-like biochemical properties. BRS-3 is classified as an orphan receptor and suggested to play a role in sperm cell division and maturation. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. The bombesin receptor family belongs to the seven transmembrane rhodopsin-like G-protein coupled receptors (class A GPCRs), which perceive extracellular signals and transduce them to guanine nucleotide-binding (G) proteins.


Pssm-ID: 320593 [Multi-domain]  Cd Length: 294  Bit Score: 120.83  E-value: 1.14e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  45 YTLSFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVTHLIF 124
Cdd:cd15927   1 YVVPILFALIFLVGVLGNGTLILIFLRNKSMRNVPNIFILSLALGDLLLLLTCVPFTSTIYTLDSWPFGEFLCKLSEFLK 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 125 SINLFGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDTYYLKTVTSASNNE---TYCRSfYP 201
Cdd:cd15927  81 DTSIGVSVFTLTALSADRYFAIVNPMRKHRSQATRRTLVTAASIWIVSILLAIPEAIFSHVVTFTLTDNqtiQICYP-YP 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 202 EHSIKEWLIGMELVSVVLGFAVPFSIIAVFYFLLARAISASS-----DQEKHSSR---------KIIFSYVVVFLVCWLP 267
Cdd:cd15927 160 QELGPNYPKIMVLLRFLVYYLIPLLIIGVFYVLMARHLIRSTrnigsGQNQAAQRqiearkkvaKTVLAFVVLFAVCWLP 239
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 268 YHVavlldiFSILHYIPFTCRLEHALFTalHVT----QCLSLVHCCVNPVLYSFINRNYR 323
Cdd:cd15927 240 RHV------FMLWFHFAPNGLVDYNAFW--HVLkivgFCLSFINSCVNPVALYLLSGSFR 291
7tmA_P2Y4 cd15374
P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled ...
51-326 2.17e-31

P2Y purinoceptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y4 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. This family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320496 [Multi-domain]  Cd Length: 285  Bit Score: 119.91  E-value: 2.17e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  51 YIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVTHLIFSINLFG 130
Cdd:cd15374   7 YGLVFVVGLPLNATALWLFIKRMRPWNPTTVYMFHLALSDTLYVLSLPTLIYYYADHNHWPFGVVACKIVRFLFYANLYC 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 131 SIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDTYYLktVTSASNNETYCrsfYPEHSIKEWLI 210
Cdd:cd15374  87 SILFLTCISVHRYVGICHPIRALRWVKPRHAYLICASVWLVVTVCLVPNLIFV--TTSRKDNITLC---HDTTRPEEFDH 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 211 GMELVSVVLG--FAVPFSIIAVFYFLLARA----ISASSDQEKHSSR----KIIFSYVVVFLVCWLPYHVAVLLdiFSIL 280
Cdd:cd15374 162 YVHYSSAVMVllFGIPCLVIVVCYGLMARRlckpRVGSSRQQGPSSKkrslKTIIMVLTVFAICFVPFHITRTL--YYVA 239
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 31083344 281 HYIPFTCRLEHALFTALHVTQCLSLVHCCVNPVLYSFINRNYRYEL 326
Cdd:cd15374 240 RLLKADCDTLNIINVTYKVTRPLASANSCLDPILYFLAGDKYRRRL 285
7tmA_GPR68_OGR1 cd15367
G protein-coupled receptor 68, member of the class A family of seven-transmembrane G ...
45-321 2.27e-31

G protein-coupled receptor 68, member of the class A family of seven-transmembrane G protein-coupled receptors; The ovarian cancer G-protein receptor 1 (OGR1, also known as GPR68) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), the T cell death associated gene-8 receptor (TDAG8, GPR65), and the G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. Knock-out mice studies have suggested that OGR1 plays a role in the regulation of insulin secretion and glucose metabolism. OGR1 couples to G(q/11) proteins and activates phospholipase C and Ca2+ signaling pathways.


Pssm-ID: 320489 [Multi-domain]  Cd Length: 276  Bit Score: 119.48  E-value: 2.27e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  45 YTLSFIYIFIFVIGMIANSVVV---WVNIQAKTtgyDTHCYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVTH 121
Cdd:cd15367   1 TLFPVVYILVLVVGLPANCLSLyygYLQIKAKN---ELGIYLCNLTVADLLYIFSLPFWLQYVLQHDNWTYSELLCKICG 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 122 LIFSINLFGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLpDTYYLKTVTSASNNETYCRSFYP 201
Cdd:cd15367  78 ILLYENIYISIGFLCCISVDRYLAVVHPFRFHAFRTMKAATLVSTVIWLKELMTCV-FFFLHGEISKDKENHSVCFEHYP 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 202 ehsIKEWLIGMELVSVVLGFAVPFSIIAVFYFLLARAISASSDQEKHSS---RKIIFSYVVVFLVCWLPYHvaVLLDIFS 278
Cdd:cd15367 157 ---IKAWEHNINYYRFYAGFLFPIFLLSFSYCRILRAVRKSHGTQKSQKiqiKRLVLSTVVIFLVCFGPYH--ILLLVRS 231
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 31083344 279 ILHYipfTCRLEHALFTALHVTQCLSLVHCCVNPVLYSFINRN 321
Cdd:cd15367 232 VFER---DCNFAEGIFNYYHFSLLLTSFNCVADPVLYCFASES 271
7tmA_SSTR2 cd15971
somatostatin receptor type 2, member of the class A family of seven-transmembrane G ...
47-323 3.69e-31

somatostatin receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs), which display strong sequence similarity with opioid receptors, binds somatostatin, a polypeptide hormone that regulates a wide variety of physiological such as neurotransmission, endocrine secretion, cell proliferation, and smooth muscle contractility. SSTRs are composed of five distinct subtypes (SSTR1-5) which are encoded by separate genes on different chromosomes. SSTR2 plays critical roles in growth hormone secretion, glucagon secretion, and immune responses. SSTR2 is expressed in the normal human pituitary and in nearly all pituitary growth hormone adenomas.


Pssm-ID: 320637 [Multi-domain]  Cd Length: 279  Bit Score: 119.18  E-value: 3.69e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  47 LSFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSlVQHNQWPMGELTCKVTHLIFSI 126
Cdd:cd15971   3 LTFIYFVVCIIGLCGNTLVIYVILRYAKMKTVTNIYILNLAIADELFMLGLPFLAIQ-VALVHWPFGKAICRVVMTVDGI 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 127 NLFGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDTYYLKTVTsaSNNETYCRSFYPEHSiK 206
Cdd:cd15971  82 NQFTSIFCLTVMSIDRYLAVVHPIKSAKWRKPRTAKMINMAVWGVSLLVILPIMIYAGVQT--KHGRSSCTIIWPGES-S 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 207 EWLIGMELVSVVLGFAVPFSIIAVFYFLL-----ARAISASSDQEKHSSRKI---IFSYVVVFLVCWLPYHVAVLLDIFS 278
Cdd:cd15971 159 AWYTGFIIYTFILGFFVPLTIICLCYLFIiikvkSSGIRVGSSKRKKSEKKVtrmVSIVVAVFVFCWLPFYIFNVSSVSV 238
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 31083344 279 ILHYIPftcrlehALFTALHVTQCLSLVHCCVNPVLYSFINRNYR 323
Cdd:cd15971 239 SISPTP-------GLKGMFDFVVVLSYANSCANPILYAFLSDNFK 276
7tmA_MCHR-like cd15088
melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G ...
46-326 5.79e-31

melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320216 [Multi-domain]  Cd Length: 278  Bit Score: 118.71  E-value: 5.79e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  46 TLSFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVTHLIFS 125
Cdd:cd15088   2 IMPSVFGCICVVGLVGNGIVLYVLVRCSKLRTAPDIFIFNLAVADLLFMLGMPFLIHQFAIDGQWYFGEVMCKIITALDA 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 126 INLFGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDTYYLKTVTSASNNETYCRSFYPEHSI 205
Cdd:cd15088  82 NNQFTSTYILTAMSVDRYLAVVHPIRSTKYRTRFVAKLVNVGLWAASFLSILPVWVYSSLIYFPDGTTFCYVSLPSPDDL 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 206 KEWLIgmelVSVVLGFAVPFSIIAVFYFL----LARAISASSDQEKHSS----RKIIFSYVVVFLVCWLPYHVAVLLDIf 277
Cdd:cd15088 162 YWFTI----YHFILGFAVPLVVITVCYILilhrLARGVAPGNQSHGSSRtkrvTKMVILIVVVFIVCWLPFHVVQLVNL- 236
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 31083344 278 silhyipFTCRLEHALFTALHVTQCLSLVHCCVNPVLYSFINRNYRYEL 326
Cdd:cd15088 237 -------AMNRPTLAFEVAYFLSICLGYANSCLNPFVYILVSENFRKRL 278
7tmA_SSTR3 cd15972
somatostatin receptor type 3, member of the class A family of seven-transmembrane G ...
50-323 7.28e-31

somatostatin receptor type 3, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR3 is coupled to inward rectifying potassium channels. SSTR3 plays critical roles in growth hormone secretion, endothelial cell cycle arrest and apoptosis. Furthermore, SSTR3 is expressed in the normal human pituitary and in nearly half of pituitary growth hormone adenomas.


Pssm-ID: 320638 [Multi-domain]  Cd Length: 279  Bit Score: 118.37  E-value: 7.28e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  50 IYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVQHnQWPMGELTCKVTHLIFSINLF 129
Cdd:cd15972   6 VYLVVCVVGLGGNTLVIYVVLRYSASESVTNIYILNLALADELFMLGLPFLAAQNALS-YWPFGSFMCRLVMTVDAINQF 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 130 GSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDTYYLKTVTSASNnetyCRSFYPEHSiKEWL 209
Cdd:cd15972  85 TSIFCLTVMSVDRYLAVVHPIRSSKWRKPPVAKTVNATVWALSFLVVLPVVIFSGVPGGMGT----CHIAWPEPA-QVWR 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 210 IGMELVSVVLGFAVPFSIIAVFYFLL-------ARAISASSDQEKHSSRKI---IFSYVVVFLVCWLPYHVavlLDIFSI 279
Cdd:cd15972 160 AGFIIYTATLGFFCPLLVICLCYLLIvvkvrssGRRVRATSTKRRGSERKVtrmVVIVVAAFVLCWLPFYA---LNIVNL 236
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 31083344 280 LHYIPftcrLEHALFTALHVTQCLSLVHCCVNPVLYSFINRNYR 323
Cdd:cd15972 237 VCPLP----EEPSLFGLYFFVVVLSYANSCANPIIYGFLSDNFK 276
7tmA_BK-1 cd15380
bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled ...
52-323 9.71e-31

bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320502 [Multi-domain]  Cd Length: 286  Bit Score: 118.36  E-value: 9.71e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  52 IFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVTHLIFSINLFGS 131
Cdd:cd15380   8 IAICFFGLLGNLFVLFVFLLPRRRLTIAEIYLANLAASDLVFVLGLPFWAENIRNQFNWPFGNFLCRVISGVIKANLFIS 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 132 IFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPdTYYLKTVTSASN-NETYCRSFYPEHSikeWLI 210
Cdd:cd15380  88 IFLVVAISQDRYRTLVHTMTSRRQRSRRQAQVICLLIWVFGGLLSIP-TFLFRSVKHVPDlNISACILLFPHEA---WHF 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 211 GMELVSVVLGFAVPFSIIAVFYFLLARAISASSDQEKHSSRKI--------IFSYVVVFLVCWLPYHVAVLLDIFSILHY 282
Cdd:cd15380 164 ARRVELNIVGFLLPLAAIVFFNFHIIASLRERTEESRKRCGGLkdtkatrlILTLVLMFLVCWTPYHFFAFLDFLFQVEV 243
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 31083344 283 IPfTCRLEHALFTALHVTQCLSLVHCCVNPVLYSFINRNYR 323
Cdd:cd15380 244 IQ-GCFWEEFIDLGLQLANFFAFANSCLNPVIYVFAGKLFR 283
7tmA_P2Y2 cd15373
P2Y purinoceptor 2, member of the class A family of seven-transmembrane G protein-coupled ...
51-323 1.36e-30

P2Y purinoceptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y2 belongs to the P2Y receptor family of purinergic G-protein coupled receptors and is implicated to play a role in the control of the cell cycle of endometrial carcinoma cells. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320495 [Multi-domain]  Cd Length: 283  Bit Score: 117.55  E-value: 1.36e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  51 YIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVTHLIFSINLFG 130
Cdd:cd15373   7 YGIVFVVGLVLNILALYVFLFRTKPWNASTTYMFNLAISDTLYVLSLPLLVYYYADENDWPFSEALCKIVRFLFYTNLYC 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 131 SIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDTYYLKtvTSASNNETYCRSFYPEHSIKEWLI 210
Cdd:cd15373  87 SILFLLCISVHRFLGVCYPVRSLRWLKVRYARIVSVVVWVIVLACQSPVLYFVT--TSDKGGNITCHDTSSPELFDQFVV 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 211 gMELVSVVLGFAVPFSIIAVFYFLLARAI------SASSDQEKHSSRKIIFSYVVVFLVCWLPYHVAVLLdiFSILHYIP 284
Cdd:cd15373 165 -YSSVMLVLLFCVPFVVILVCYALMVRKLlkpsagTSTNSRSKKKSVKMIIIVLAVFILCFLPFHVTRTL--YYSFRSMD 241
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 31083344 285 FTCRLEHALFTALHVTQCLSLVHCCVNPVLYSFINRNYR 323
Cdd:cd15373 242 LSCGTLNAINLAYKVTRPLASANSCLDPILYFLAGQSFR 280
7tmA_P2Y3-like cd16001
P2Y purinoceptor 3-like proteins, member of the class A family of seven-transmembrane G ...
45-326 1.38e-30

P2Y purinoceptor 3-like proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y3-like proteins are an uncharacterized group that belongs to the G(i) class of a family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320667 [Multi-domain]  Cd Length: 284  Bit Score: 117.55  E-value: 1.38e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  45 YTLSFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVTHLIF 124
Cdd:cd16001   1 ILLPVTYSVVFVLGLPLNGTVLWLSWCRTKRWTCSTIYLVNLAVADLLYVCSLPLLIVNYAMRDRWPFGDFLCKLVRFLF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 125 SINLFGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDTYYLKTVTsaSNNETYCRSFY-PEH 203
Cdd:cd16001  81 YTNLYGSILFLTCISVHRFLGVCYPIRSLAYRTRRLAVIGSAATWILVVLQLLPTLVYARTGS--INNRTVCYDLTsPDN 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 204 SIKEWLIGMELvsVVLGFAVPFSIIAVFYFLLARAISASSDQ---EKHSSRKIIFSYVVV---FLVCWLPYHVAVLLDIF 277
Cdd:cd16001 159 FGNYFPYGMVL--TVTGFLIPFLIILLCYCLMIKSLIRSEEAagvGKAARAKSIRTILLVcglFALCFVPFHITRTIYLF 236
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 31083344 278 SILHYIPfTCRLEHALFTALHVTQCLSLVHCCVNPVLYSFINRNYRYEL 326
Cdd:cd16001 237 VRVYLVQ-DCPLLQFVSLAYKIWRPLVSFNSCINPLLYFLSGDSNRLRL 284
7tmA_GPR65_TDAG8 cd15365
proton-sensing G protein-coupled receptor 65, member of the class A family of ...
45-326 3.16e-30

proton-sensing G protein-coupled receptor 65, member of the class A family of seven-transmembrane G protein-coupled receptors; The T cell death associated gene-8 receptor (TDAG8, also known as GPR65) is a member of the proton-sensing G-protein-coupled receptor (GPCR) family which also includes the G2 accumulation receptor (G2A, also known as GPR132), ovarian cancer G-protein receptor 1 (OGR-1, GPR68), and G-protein-coupled receptor 4 (GPR4). Proton-sensing G-protein coupled receptors sense pH of 7.6 to 6.0 and mediates a variety of biological activities in neutral and mildly acidic pH conditions, whereas the acid-sensing ionotropic ion channels typically sense strong acidic pH. Activation of TDAG8 by extracellular acidosis increases the cAMP production, stimulates Rho, and induces stress fiber formation. TDAG8 has also been shown to regulate the extracellular acidosis-induced inhibition of pro-inflammatory cytokine production in peritoneal macrophages.


Pssm-ID: 320487 [Multi-domain]  Cd Length: 277  Bit Score: 116.42  E-value: 3.16e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  45 YTLSFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVTHLIF 124
Cdd:cd15365   1 YLFPFVYIFVIVISIPSNCISLYVSCLQIRKKNELGVYLFNLSLSDLLYIVILPLWIDYLWNGDNWTLSGFVCIFSAFLL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 125 SINLFGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSlPDTYYLKTVTSASNNETYCRSFYPehs 204
Cdd:cd15365  81 YTNFYTSTALLTCIALDRYLAVVHPLKFMHLRTIRTALSVSVAIWLLEICFN-AVILTWEDSFHESSSHTLCYDKFP--- 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 205 IKEWLIGMELVSVVLGFAVPFSIIAVFYFLLARAI---SASSDQEKHSSRKIIFSYVVVFLVCWLPYHVAVLldIFSILH 281
Cdd:cd15365 157 LEDWQARLNLFRICLGYLLPLLIILFCYWKIYQAVrsnQATEDQEKKKIFKLLLLITVTFVICFTPYHVVLL--IRSIVE 234
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 31083344 282 yiPFTCRLEHALFTALHVTQCLSLVHCCVNPVLYSFINRNYRYEL 326
Cdd:cd15365 235 --PCDCRNAKWLYTLYKITVALTSLNCIADPFLYCFVTESGRADI 277
7tmA_UII-R cd14999
urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled ...
46-323 3.52e-30

urotensin-II receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The urotensin-II receptor (UII-R, also known as the hypocretin receptor) is a member of the class A rhodopsin-like G-protein coupled receptors, which binds the peptide hormone urotensin-II. Urotensin II (UII) is a vasoactive somatostatin-like or cortistatin-like peptide hormone. However, despite the apparent structural similarity to these peptide hormones, they are not homologous to UII. Urotensin II was first identified in fish spinal cord, but later found in humans and other mammals. In fish, UII is secreted at the back part of the spinal cord, in a neurosecretory centre called uroneurapophysa, and is involved in the regulation of the renal and cardiovascular systems. In mammals, urotensin II is the most potent mammalian vasoconstrictor identified to date and causes contraction of arterial blood vessels, including the thoracic aorta. The urotensin II receptor is a rhodopsin-like G-protein coupled receptor, which binds urotensin-II. The receptor was previously known as GPR14, or sensory epithelial neuropeptide-like receptor (SENR). The UII receptor is expressed in the CNS (cerebellum and spinal cord), skeletal muscle, pancreas, heart, endothelium and vascular smooth muscle. It is involved in the pathophysiological control of cardiovascular function and may also influence CNS and endocrine functions. Binding of urotensin II to the receptor leads to activation of phospholipase C, through coupling to G(q/11) family proteins. The resulting increase in intracellular calcium may cause the contraction of vascular smooth muscle.


Pssm-ID: 320130 [Multi-domain]  Cd Length: 282  Bit Score: 116.77  E-value: 3.52e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  46 TLSFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPvWVVSLVQHNQWPMGELTCKvthLIFS 125
Cdd:cd14999   1 AIGTVLSLMCVVGVAGNVYTLVVMCLSMRPRASMYVYILNLALADLLYLLTIP-FYVSTYFLKKWYFGDVGCR---LLFS 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 126 INLF---GSIFFLTCMSVDRYLSITYFTNTpSSRKKMVRRVVCILVWLLAFCVSLPDTYYLKTVT---SASNNETYCRSF 199
Cdd:cd14999  77 LDFLtmhASIFTLTVMSTERYLAVVKPLDT-VKRSKSYRKLLAGVIWLLSLLLTLPMAIMIRLVTvedKSGGSKRICLPT 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 200 YPEHSIKEWLIgmelVSVVLGFAVPFSIIAVFYFLLARAI-----SASSDQEKHSSR----KIIFSYVVVFLVCWLPYHV 270
Cdd:cd14999 156 WSEESYKVYLT----LLFSTSIVIPGLVIGYLYIRLARKYwlsqaAASNSSRKRLPKqkvlKMIFTIVLVFWACFLPFWI 231
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 31083344 271 AVLLDIFSilhyiPFTCRLEHALFTALHVTQCLSLVHCCVNPVLYSFINRNYR 323
Cdd:cd14999 232 WQLLYLYS-----PSLSLSPRTTTYVNYLLTCLTYSNSCINPFLYTLLTKNYK 279
7tmA_GPR55-like cd15165
G protein-coupled receptor 55 and similar proteins, member of the class A family of ...
50-323 5.08e-30

G protein-coupled receptor 55 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR55 shares closest homology with GPR35, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. GPR55 has been reported to couple to G(13), G(12), or G(q) proteins. Activation of GPR55 leads to activation of phospholipase C, RhoA, ROCK, ERK, p38MAPK, and calcium release. Lysophosphatidylinositol (LPI) is currently considered as the endogenous ligand for GPR55, although the receptor was initially de-orphanized as a cannabinoid receptor and binds many cannabinoid ligands.


Pssm-ID: 320293 [Multi-domain]  Cd Length: 277  Bit Score: 115.89  E-value: 5.08e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  50 IYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSlvQHNQWPMGELTCKVTHLIFSINLF 129
Cdd:cd15165   6 VYIPTFVLGLLLNLMALWVFLFKIKKWTESTIYMINLALNDLLLLLSLPFKMHS--SKKQWPLGRTLCSFLESLYFVNMY 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 130 GSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPdTYYLKtvtSASNNETYCrsfYPEHSIKEWL 209
Cdd:cd15165  84 GSILIIVCISVDRYIAIRHPFLAKRLRSPRKAAIVCLTIWVFVWAGSIP-IYSFH---DKPTNNTRC---FHGFSNKTWS 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 210 IGMELVSVVLGFAVPFSIIAVFYF-----LLARAISASSDQEKHSSRKIIFSYVVVFLVCWLPYHVAVLLDIFSILHYIP 284
Cdd:cd15165 157 KKVIVVVEEFGFLIPMAVMVFCSVqiirtLLDMRRPEQPKVKQNKSVKIVLSNLVVFLVCFTPYHLGIFLQFLVKNDIIN 236
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 31083344 285 fTCRLEHALFTALHVTQCLSLVHCCVNPVLYSFINRNYR 323
Cdd:cd15165 237 -DCSTKQSIRLFVQVSMCLANVNCCLDAICYYFILKEFR 274
7tmA_PAR cd15162
protease-activated receptors, member of the class A family of seven-transmembrane G ...
46-323 7.97e-30

protease-activated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes purinergic receptor P2Y8 and protease-activated receptors. P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PAR3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 341328 [Multi-domain]  Cd Length: 280  Bit Score: 115.62  E-value: 7.97e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  46 TLSFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVTHLIFS 125
Cdd:cd15162   2 FLPAVYTLVFVVGLPANGMALWVLLFRTKKKAPAVIYMANLAIADLLLVIWLPFKIAYHIHGNNWIFGEALCRLVTVAFY 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 126 INLFGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDTYYLKTVTSASNNETYCRSFYPEHSI 205
Cdd:cd15162  82 GNMYCSILLLTCISIDRYLAIVHPMGHRRLRARRYALGTCLAIWLLALLVTLPLYLVKQTIFLPALDITTCHDVLPEQLL 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 206 KEWLIGMELVSVVLGFAVPFSIIAVFYFLLARAISASSDQ--EKHSSRKIIFSYVV--VFLVCWLPYHVAVlldifsILH 281
Cdd:cd15162 162 VGDWFYYFLSLAIVGFLIPFILTASCYVATIRTLAALEDEnsEKKKKRAIKLAATVlaIFIICFAPSNLLL------LAH 235
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 31083344 282 YIPFTCRLEHALFTALHVTQCLSLVHCCVNPVLYSFINRNYR 323
Cdd:cd15162 236 YSLISSSGTGHLYFAYLLALCLSTLNSCIDPFIYYFVSKEFR 277
7tmA_SSTR5 cd15974
somatostatin receptor type 5, member of the class A family of seven-transmembrane G ...
47-323 1.22e-29

somatostatin receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR5 is coupled to inward rectifying K channels and phospholipase C, and plays critical roles in growth hormone and insulin secretion. SSTR5 acts as a negative regulator of PDX-1 (pancreatic and duodenal homeobox-1) expression, which is a conserved homeodomain-containing beta cell-specific transcription factor essentially involved in pancreatic development, among many other functions.


Pssm-ID: 320640 [Multi-domain]  Cd Length: 277  Bit Score: 114.90  E-value: 1.22e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  47 LSFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPvWVVSLVQHNQWPMGELTCKVTHLIFSI 126
Cdd:cd15974   3 IPVIYLLVCAIGLSGNTLVIYVVLRYAKMKTVTNIYILNLAVADELFMLGLP-FLATQNAISYWPFGSFLCRLVMTVDGV 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 127 NLFGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDTYYlktvTSASNNETYCRSFYPEhSIK 206
Cdd:cd15974  82 NQFTSIFCLTVMSIDRYLAVVHPIKSTKWRRPRVAKLINATVWTLSFLVVLPVIIF----SDVQPDLNTCNISWPE-PVS 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 207 EWLIGMELVSVVLGFAVPFSIIAVFYFLLARAISAS-----SDQEKHSSRKI---IFSYVVVFLVCWLPYHVavlLDIFS 278
Cdd:cd15974 157 VWSTAFIIYTAVLGFFGPLLVICLCYLLIVIKVKSSglrvgSTKRRKSERKVtrmVVIIVVVFVFCWLPFYM---LNIVN 233
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 31083344 279 ILHYIPftcrlEHALFTALH-VTQCLSLVHCCVNPVLYSFINRNYR 323
Cdd:cd15974 234 LIVILP-----EEPAFVGVYfFVVVLSYANSCANPILYGFLSDNFK 274
7tmA_CCRL2 cd15171
CC chemokine receptor-like 2, member of the class A family of seven-transmembrane G ...
50-326 1.83e-29

CC chemokine receptor-like 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokine (CC-motif) receptor-like 2 (CCRL2) is a member of the atypical chemokine receptor family. CCRL2, like other atypical receptors, has an alteration in the conserved DRYLAIV motif in the third intracellular loop, which is essential for GPCR coupling and signaling. CCR2L is expressed in most hematopoietic cells and many lymphoid organs as well as in heart and lung. CCRL2 was initially reported to promote chemotaxis and calcium fluxes in responses to chemokines (CCL2, CCL5, CCL7, and CCL8); however, these results are still controversial. More recently, chemerin, a chemotactic agonist of CMKLR1 (chemokine-like receptor-1) and GPR1, was identified as a novel non-signaling ligand for both human and mouse CCRL2. Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C).


Pssm-ID: 320299  Cd Length: 279  Bit Score: 114.54  E-value: 1.83e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  50 IYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVvslvqHNQWPMGEL---TCKVTHLIFSI 126
Cdd:cd15171   6 LCSAVFLVGLLDNGLVVFILVKYKGLKHVENIYFLNLAVSNLCFLLTLPFWA-----HAAWHGGSLgnpTCKVLVALSSV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 127 NLFGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVV-CILVWLLAFCVSLPDTYYLKTVTSASNNETYCRS--FYPEH 203
Cdd:cd15171  81 GLHSEALFNVLLTVQASRVFFHGRLASSARRVAPCGIIaSVLAWLTAFLVTLPEFVFYKPQMDSQKSKCAFSRphFLPAE 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 204 SiKEWLIGMELVSVVLGFAVPFSIIAVFYFLLARaiSASSDQEKHSSRKIIFSYVVVFLVCWLPYHVAVLLDIFSiLHYI 283
Cdd:cd15171 161 E-TFWKYFLTLKMNIVVLVFPLLVFIICCVQLRK--TQRFRERQRDLSKLVFAIMVVFLLMWAPYNIALFLSAFK-EHFS 236
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 31083344 284 PFTCRLEHALFTALHVTQCLSLVHCCVNPVLYSFINRNYRYEL 326
Cdd:cd15171 237 LRDCKSSYHLDASVQVTKLIATTHCCVNPLLYALLDPAFRRRL 279
7tmA_PAFR cd15147
platelet-activating factor receptor, member of the class A family of seven-transmembrane G ...
50-326 3.34e-29

platelet-activating factor receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The platelet-activating factor receptor is a G(q/11)-protein coupled receptor, which is linked to p38 MAPK and PI3K signaling pathways. PAF is a phospholipid (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) which is synthesized by cells especially involved in host defense such as platelets, macrophages, neutrophils, and monocytes. PAF is well-known for its ability to induce platelet aggregation and anaphylaxis, and also plays important roles in allergy, asthma, and inflammatory responses, among many others.


Pssm-ID: 320275 [Multi-domain]  Cd Length: 291  Bit Score: 114.08  E-value: 3.34e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  50 IYIFIFVIGMIANSVVVWV--NIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVTHLIFSIN 127
Cdd:cd15147   6 VYSIIFVLGLIANCYVLWVfaRLYPSKKLNEIKIFMVNLTIADLLFLITLPFWIVYYHNEGNWILPKFLCNVAGCLFFIN 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 128 LFGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLpdtYYL-----KTVTSASNNETYCRSFYPE 202
Cdd:cd15147  86 TYCSVAFLGVISYNRYQAVTRPIKTAQSTTRKRGIIISVAIWVIIVASAS---YFLfmdstNTVKIDSGNFTRCFEGYEK 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 203 HSIKEWLIGMelVSVVLGFAVPFSIIAVFYFLLARAISASSDQE------KHSSRKIIFSYVVVFLVCWLPYHVAVLLDI 276
Cdd:cd15147 163 DNSKPVLIIH--FIIIGLFFLVFLLILVCNLVIARTLLSQPVQGqrnagvKRRALWMVCTVLAVFVICFVPHHVVQGPWT 240
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 31083344 277 FSILHYIPFT-CRLEHALFTALHVTQCLSLVHCCVNPVLYSFINRNYRYEL 326
Cdd:cd15147 241 LAVLQQWRYWdCQFRQALNDAHQITLCLMSTNCVLDPVIYCFLTKKFRKHL 291
7tmA_CysLTR2 cd15157
cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G ...
50-326 3.56e-29

cysteinyl leukotriene receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Cysteinyl leukotrienes (LTC4, LTD4, and LTE4) are the most potent inflammatory lipid mediators that play an important role in human asthma. They are synthesized in the leucocytes (cells of immune system) from arachidonic acid by the actions of 5-lipoxygenase and induce bronchial constriction through G protein-coupled receptors, CysLTR1 and CysLTR2. Activation of CysLTR1 by LTD4 induces airway smooth muscle contraction and proliferation, eosinophil migration, and damage to the lung tissue. They belong to the class A GPCR superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320285 [Multi-domain]  Cd Length: 278  Bit Score: 113.65  E-value: 3.56e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  50 IYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVTHLIFSINLF 129
Cdd:cd15157   6 VYLIIFVLGVVGNGLSIYVFLQPSKKKTSVNIFMLNLAVSDLMFVSTLPFRADYYLMGSHWVFGDIACRIMSYSLYVNMY 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 130 GSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPdtyYLKTVTSASNNETYCRSFYPEHSIKewL 209
Cdd:cd15157  86 CSIYFLTVLSIVRFLAIVHPFKLWKVTSIKYARILCAVIWIFVMAASSP---LLSKGTSKYNSQTKCLDLHPSKIDK--L 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 210 IGMELVSVVLGFAVPFSIIAVFYFLLARAISAS---SDQEKHSSRKIIFSYVV---VFLVCWLPYHVavlLDIFSILHYI 283
Cdd:cd15157 161 LILNYIVLVVGFILPFCTLSICYILIIKALLKPrvpQSKLRVSHKKALLTIIItliLFLLCFLPYHI---LRTVHLMQWS 237
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 31083344 284 PFTCRLehALFTALHVTQCLSLVHCCVNPVLYSFINRNYRYEL 326
Cdd:cd15157 238 EGQCNL--RLHKAVVITLCLAAANSCLDPLLYYFAGENFKERL 278
7tmA_TACR cd15390
neurokinin receptors (or tachykinin receptors), member of the class A family of ...
48-324 5.03e-29

neurokinin receptors (or tachykinin receptors), member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320512 [Multi-domain]  Cd Length: 289  Bit Score: 113.54  E-value: 5.03e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  48 SFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVL--TIPVWVVSLvqHNQWPMGELTCKVTHLIFS 125
Cdd:cd15390   4 SIVFVVMVLVAIGGNLIVIWIVLAHKRMRTVTNYFLVNLAVADLLISAfnTVFNFTYLL--YNDWPFGLFYCKFSNFVAI 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 126 INLFGSIFFLTCMSVDRYLSITYFTNTPSSRKkmVRRVVCILVWLLAFCVSLPDTYYLKTVT---SASNNETYCRSFYPE 202
Cdd:cd15390  82 TTVAASVFTLMAISIDRYIAIVHPLRPRLSRR--TTKIAIAVIWLASFLLALPQLLYSTTETyyyYTGSERTVCFIAWPD 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 203 HSIKEWLIGMELVSVVLGFAVPFSIIAVFYFLLARAISASSDQEKHSSR------------KIIFSYVVVFLVCWLPYHV 270
Cdd:cd15390 160 GPNSLQDFVYNIVLFVVTYFLPLIIMAVAYTRVGVELWGSKTIGENTPRqlesvrakrkvvKMMIVVVVIFAICWLPYHL 239
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 31083344 271 avlldIFSILHYIPFTCRLEHALFTALhVTQCLSLVHCCVNPVLYSFINRNYRY 324
Cdd:cd15390 240 -----YFILTYLYPDINSWKYIQQIYL-AIYWLAMSNSMYNPIIYCWMNKRFRY 287
7tmA_PR4-like cd15392
neuropeptide Y receptor-like found in insect and related proteins, member of the class A ...
49-323 1.08e-28

neuropeptide Y receptor-like found in insect and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a novel G protein-coupled receptor (also known as PR4 receptor) from Drosophila melanogaster, which can be activated by the members of the neuropeptide Y (NPY) family, including NPY, peptide YY (PYY) and pancreatic polypeptide (PP), when expressed in Xenopus oocytes. These homologous peptides of 36-amino acids in length contain a hairpin-like structural motif, which referred to as the pancreatic polypeptide fold, and function as gastrointestinal hormones and neurotransmitters. The PR4 receptor also shares strong sequence homology to the mammalian tachykinin receptors (NK1R, NK2R, and NK3R), whose endogenous ligands are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB), respectively. The tachykinins function as excitatory transmitters on neurons and cells in the gastrointestinal tract.


Pssm-ID: 320514 [Multi-domain]  Cd Length: 287  Bit Score: 112.84  E-value: 1.08e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  49 FIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIAD-LWVVLTIPVWVVSLVQHNQWPMGELTCKVTHLIFSIN 127
Cdd:cd15392   5 LMYSTIFVLAVGGNGLVCYIVVSYPRMRTVTNYFIVNLALSDiLMAVFCVPFSFIALLILQYWPFGEFMCPVVNYLQAVS 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 128 LFGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVrrVVCILVWLLAFCVSLPDTYYLKTV--TSASNNETYCRSFYPEHSI 205
Cdd:cd15392  85 VFVSAFTLVAISIDRYVAIMWPLRPRMTKRQAL--LLIAVIWIFALATALPIAITSRLFedSNASCGQYICTESWPSDTN 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 206 KEWligMELVSVVLGFAVPFSIIAVFYFLLARAI---------SASSDQEKHSSR----KIIFSYVVVFLVCWLPYHVAV 272
Cdd:cd15392 163 RYI---YSLVLMILQYFVPLAVLVFTYTRIGIVVwakrtpgeaENNRDQRMAESKrklvKMMITVVAIFALCWLPLNILN 239
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 31083344 273 LL--DIFSILH--YIPFtcrlehaLFTALHVtqcLSLVHCCVNPVLYSFINRNYR 323
Cdd:cd15392 240 LVgdHDESIYSwpYIPY-------LWLAAHW---LAMSHCCYNPFIYCWMNAKFR 284
7tmA_PAR4 cd15372
protease-activated receptor 4, member of the class A family of seven-transmembrane G ...
50-323 1.29e-28

protease-activated receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320494 [Multi-domain]  Cd Length: 274  Bit Score: 112.15  E-value: 1.29e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  50 IYIFIFVIGMIANSVVVWVnIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVTHLIFSINLF 129
Cdd:cd15372   6 LYTLVFLVGLPANGLALWV-LATQVKRLPSTIFLINLAVADLLLILVLPFKISYHFLGNNWPFGEGLCRVVTAFFYGNMY 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 130 GSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDTYYLKTVTSASNNETYCRSFYPEHSIKEWL 209
Cdd:cd15372  85 CSVLLLMCISLDRYLAVVHPFFARTLRSRRFALCMCTAIWLIAAALTLPLTLQRQSYPLERLNITLCHDVLPLDEQDTYL 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 210 IGMELVSVVLGFAVPFSIIAVFYFLLARAISASSDQEKHSSRKIIFsYVVVFLVCWLPYHVAVLldifsiLHYIPFTCRL 289
Cdd:cd15372 165 FYYFACLAVLGFLLPLVVILFCYGSVLHTLLRSGQRYGHAMKLTVL-VLVSFVLCFTPSNLLLL------LHYSDPTLDD 237
                       250       260       270
                ....*....|....*....|....*....|....
gi 31083344 290 EHALFTALHVTQCLSLVHCCVNPVLYSFINRNYR 323
Cdd:cd15372 238 GGNLYIVYMVSLAISTLNSCVDPFIYYYVSEEFR 271
7tmA_LPAR4 cd15155
lysophosphatidic acid receptor 4, member of the class A family of seven-transmembrane G ...
50-323 1.41e-28

lysophosphatidic acid receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 4 (LPAR4) is a G protein-coupled receptor that binds and is activated by the bioactive lipid lysophosphatidic acid (LPA), which is released by activated platelets and constitutively found in serum. Phylogenetic analysis of the class A GPCRs shows that LAPR4 is classified into the cluster consisting receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production. Activation of LPAR5 is coupled to G(12/13) proteins, leading to neurite retraction and stress fiber formation, whereas coupling to G(q) protein leads to increases in calcium levels.


Pssm-ID: 320283 [Multi-domain]  Cd Length: 283  Bit Score: 112.32  E-value: 1.41e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  50 IYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVqHNQWPMGELTCKVTHLIFSINLF 129
Cdd:cd15155   6 VYSVVFILGLITNCASLFVFCFRMKMRNETAIFMTNLAVSDLLFVFTLPFKIFYNF-NRHWPFGDSLCKISGTAFLTNIY 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 130 GSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDTYYlkTVTSASNNETYCRSFYPEHSIKEWL 209
Cdd:cd15155  85 GSMLFLTCISVDRFLAIVYPFRSRTIRTRRNSAIVCAGVWILVLSGGISASLF--STTNVSNTSTTCFEGFSKSIWKTYL 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 210 IGMELVSVVLGFAVPFSIIAVFYFLLAR-----AISASSDQEKHSSRKIIFSYVVVFLVCWLPYHVAVLLDIFSILHYIP 284
Cdd:cd15155 163 SKITIFIEVVGFIIPLLLNLTCSSLVLRtlrkpATLSQIGTNKEKVLKMILVHVAIFVVCFVPYNSILFLYALVRSQAIA 242
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 31083344 285 fTCRLEHALFTALHVTQCLSLVHCCVNPVLYSFINRNYR 323
Cdd:cd15155 243 -NCGVERFARTMYPITLCLATLNCCFDPFVYYFTSESFQ 280
7tmA_CMKLR1 cd15116
chemokine-like receptor 1, member of the class A family of seven-transmembrane G ...
50-326 2.57e-28

chemokine-like receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokine receptor-like 1 (also known as Chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. CMKLR1 is prominently expressed in dendritic cells and macrophages.


Pssm-ID: 320244 [Multi-domain]  Cd Length: 284  Bit Score: 111.78  E-value: 2.57e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  50 IYIFIFVIGMIANSVVVWVnIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVTHLIFSINLF 129
Cdd:cd15116   6 IYSVVFVLGVLGNGLVIFI-TGFKMKKTVNTVWFLNLAVADFLFTFFLPFSIAYTAMDFHWPFGRFMCKLNSFLLFLNMF 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 130 GSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDTYYLKTVTSASNNETYCRSFYP-----EHS 204
Cdd:cd15116  85 TSVFLLTVISIDRCISVVFPVWSQNHRSVRLASLVSLAVWVVAFFLSSPSFIFRDTAPSQNNNKIICFNNFSlsgdnSSP 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 205 IKEWLIGMELVSVV-----LGFAVPFSIIAVFYFLLARAISASSDQEKHSSRKIIFSYVVVFLVCWLPYHVAVLLDIFSi 279
Cdd:cd15116 165 EVNQLRNMRHQVMTitrflLGFLIPFTIIICCYAAIVLKLKRNRLAKSSKPFKIIAAVIVTFFLCWAPYHILNLLEMEA- 243
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 31083344 280 lhyipfTCRLEHALFTALHVTQCLSLVHCCVNPVLYSFINRNYRYEL 326
Cdd:cd15116 244 ------TRSPASVFKIGLPITSSLAFINSCLNPILYVFMGQDFKKFK 284
7tmA_RNL3R2 cd15925
relaxin-3 receptor 2 (RNL3R2), member of the class A family of seven-transmembrane G ...
47-326 2.66e-28

relaxin-3 receptor 2 (RNL3R2), member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled receptor RNL3R2 is also known as GPR100, GPR142, and relaxin family peptide receptor 4 (RXFP4). Insulin-like peptide 5 (INSL5) is an endogenous ligand for RNL3R2 and plays a role in fat and glucose metabolism. INSL5 is highly expressed in human rectal and colon tissues. RNL3R2 signals through G(i) protein and inhibit adenylate cyclase, thereby inhibit cAMP accumulation.


Pssm-ID: 320591 [Multi-domain]  Cd Length: 283  Bit Score: 111.50  E-value: 2.66e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  47 LSFIYIFIFVIGMIANSVVVW-VNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVTHLIFS 125
Cdd:cd15925   3 VALAYGLVCAIGLLGNLAVMYlLRNCARRAPPPIDVFVFNLALADFGFALTLPFWAVESALDFHWPFGGAMCKMVLTATV 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 126 INLFGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDTYYlkTVTSASNNETYCRSFYPEhsi 205
Cdd:cd15925  83 LNVYASVFLLTAMSVTRYWVVASAAGPGTHLSTFWAKIITLALWAAALLATVPTAIF--ATEGEVCGVELCLLKFPS--- 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 206 KEWLIGMELVSVVLGFAVPFSIIAVFY-----FLLARAISASSDQEKHSSRKIIFSYVVVFLVCWLPYHVAVLLDIFSIL 280
Cdd:cd15925 158 NYWLGAYHLQRVVVAFVVPLGVITTSYllllsFLQQHKVNQNNRQRQSVIARSVRLVVASFFLCWFPNHVVTFWGVLVKF 237
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 31083344 281 HYIPFTCRLEHALFTALHVTQCLSLVHCCVNPVLYSFINRNYRYEL 326
Cdd:cd15925 238 RAVPWNSTFYFIHTYVFPVTTCLAHSNSCLNPVLYCLMRREFRQAL 283
7tmA_KiSS1R cd15095
KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of ...
50-323 5.45e-28

KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled KiSS1-derived peptide receptor (GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (previously known as metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. The KiSS1 receptor is coupled to G proteins of the G(q/11) family, which lead to activation of phospholipase C and increase of intracellular calcium. This signaling cascade plays an important role in reproduction by regulating the secretion of gonadotropin-releasing hormone.


Pssm-ID: 320223 [Multi-domain]  Cd Length: 288  Bit Score: 110.83  E-value: 5.45e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  50 IYIFIFVIGMIANSVVVWV---NIQAKTTgydTHCYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVTHLIFSI 126
Cdd:cd15095   6 IFAIIFLVGLAGNSLVIYVvsrHREMRTV---TNYYIVNLAVTDLAFLVCCVPFTAALYATPSWVFGDFMCKFVNYMMQV 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 127 NLFGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDTYYLKTVTSASN-NETYCRSFYPEHSI 205
Cdd:cd15095  83 TVQATCLTLTALSVDRYYAIVHPIRSLRFRTPRVAVVVSACIWIVSFLLSIPVAIYYRLEEGYWYgPQTYCREVWPSKAF 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 206 KewlIGMELVSVVLGFAVPFSIIAVFYFL----LARAISASSDQEKHSSR----------KIIFSYVVVFLVCWLPYHVA 271
Cdd:cd15095 163 Q---KAYMIYTVLLTYVIPLAIIAVCYGLilrrLWRRSVDGNNQSEQLSEralrqkrkvtRMVIVVVVLFAICWLPNHVL 239
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 31083344 272 VLLDIFSILHyiPFTCRLEHALFTALhvtqCLSLVHCCVNPVLYSFINRNYR 323
Cdd:cd15095 240 NLWQRFDPNF--PETYATYALKIAAL----CLSYANSAVNPFVYAFMGENFR 285
7tmA_P2Y6 cd15379
P2Y purinoceptor 6, member of the class A family of seven-transmembrane G protein-coupled ...
47-323 7.15e-28

P2Y purinoceptor 6, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes mammalian P2Y6, avian P2Y3, and similar proteins. P2Y3 is the avian homolog of mammalian P2Y6. They belong to the G(i) class of a family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320501 [Multi-domain]  Cd Length: 288  Bit Score: 110.35  E-value: 7.15e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  47 LSFIYIFIFVIGMIANSVVV---WVNIQAKTTgydTHCYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVTHLI 123
Cdd:cd15379   3 LPLVYSVVFLLGLPLNAVVIgqiWATRQALSR---TTIYMLNLATADLLYVCSLPLLIYNYTQKDYWPFGDFTCRLVRFQ 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 124 FSINLFGSIFFLTCMSVDRYLSITYFTNTPSSRK-KMVRRVVCILVWLLAFCVSLPDTYYLKTVTsaSNNETYCRSFY-P 201
Cdd:cd15379  80 FYTNLHGSILFLTCISVQRYLGICHPLASWHKKKgKKLTWLVCGAVWLVVIAQCLPTFVFASTGT--QRNRTVCYDLSpP 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 202 EHSIKEWLIGMELvsVVLGFAVPFSIIAVFYFLLAR---------AISASSDQEKHSSRKIIFSYVVVFLVCWLPYHVAV 272
Cdd:cd15379 158 ARSTAYFPYGITL--TRTGFLLPFAARLACYCSMATilcrvviavAVVAAPGEKRGKAARMIIVVAAVFLISFLPFHYTK 235
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 31083344 273 LldIFSILHYIP-FTCRLEHALFTALHVTQCLSLVHCCVNPVLYSFINRNYR 323
Cdd:cd15379 236 T--RYLQVRSWDgGPCTTRQAFAEAYKRTRPFASMNSVLDPILFYFTQSKFR 285
7tmA_TACR-like cd15202
tachykinin receptors and related receptors, member of the class A family of ...
47-326 1.59e-27

tachykinin receptors and related receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the neurokinin/tachykinin receptors and its closely related receptors such as orphan GPR83 and leucokinin-like peptide receptor. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320330 [Multi-domain]  Cd Length: 288  Bit Score: 109.52  E-value: 1.59e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  47 LSFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWV-VLTIPVWVVSLVqHNQWPMGELTCKVTHLIFS 125
Cdd:cd15202   3 LIVAYSFIIVFSLFGNVLVCWIIFKNQRMRTVTNYFIVNLAVADIMItLFNTPFTFVRAV-NNTWIFGLFMCHFSNFAQY 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 126 INLFGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVrrVVCILVWLLAFCVSLPDTYYLKTVTSASNNE---TYCRSFYPE 202
Cdd:cd15202  82 CSVHVSAYTLTAIAVDRYQAIMHPLKPRISKTKAK--FIIAVIWTLALAFALPHAICSKLETFKYSEDivrSLCLEDWPE 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 203 HSIKEWLIgMELVSVVLGFAVPFSIIAVFYFLLARAISASS---------DQEKHSSR----KIIFSYVVVFLVCWLPYH 269
Cdd:cd15202 160 RADLFWKY-YDLALFILQYFLPLLVISFAYARVGIKLWASNmpgdatterYFALRRKKkkviKMLMVVVVLFALCWLPFN 238
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 31083344 270 VAVLL-DIFSILHYIPFtcrleHALFTALHvtqCLSLVHCCVNPVLYSFINRNYRYEL 326
Cdd:cd15202 239 IYVLLlSSKPDYLIKTI-----NAVYFAFH---WLAMSSTCYNPFIYCWLNERFRIEF 288
7tmA_amine_R-like cd14967
amine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
46-323 1.61e-27

amine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Amine receptors of the class A family of GPCRs include adrenoceptors, 5-HT (serotonin) receptors, muscarinic cholinergic receptors, dopamine receptors, histamine receptors, and trace amine receptors. The receptors of amine subfamily are major therapeutic targets for the treatment of neurological disorders and psychiatric diseases. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320098 [Multi-domain]  Cd Length: 259  Bit Score: 108.80  E-value: 1.61e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  46 TLSFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLT-IPVWVVSLVQHNqWPMGELTCKVTHLIF 124
Cdd:cd14967   1 LLAVFLSLIILVTVFGNLLVILAVYRNRRLRTVTNYFIVSLAVADLLVALLvMPFSAVYTLLGY-WPFGPVLCRFWIALD 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 125 SINLFGSIFFLTCMSVDRYLSITY-FTNTPSSRKKMVRRVVCIlVWLLAFCVSLPdTYYLKTVTSASNNETYCRSFYPEh 203
Cdd:cd14967  80 VLCCTASILNLCAISLDRYLAITRpLRYRQLMTKKRALIMIAA-VWVYSLLISLP-PLVGWRDETQPSVVDCECEFTPN- 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 204 sikewlIGMELVSVVLGFAVPFSIIAVFYFLLARAISassdQEKHSSRKIIFsYVVVFLVCWLPYHVAVLLDIFSILHYI 283
Cdd:cd14967 157 ------KIYVLVSSVISFFIPLLIMIVLYARIFRVAR----RELKAAKTLAI-IVGAFLLCWLPFFIIYLVSAFCPPDCV 225
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 31083344 284 PFTCrleHALFTALHVtqclslVHCCVNPVLYSFINRNYR 323
Cdd:cd14967 226 PPIL---YAVFFWLGY------LNSALNPIIYALFNRDFR 256
7tmA_Mu_opioid_R cd15090
opioid receptor subtype mu, member of the class A family of seven-transmembrane G ...
46-323 1.62e-27

opioid receptor subtype mu, member of the class A family of seven-transmembrane G protein-coupled receptors; The mu-opioid receptor binds endogenous opioids such as beta-endorphin and endomorphin. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320218 [Multi-domain]  Cd Length: 279  Bit Score: 109.31  E-value: 1.62e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  46 TLSFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVQhNQWPMGELTCKVTHLIFS 125
Cdd:cd15090   2 TIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLM-GTWPFGNILCKIVISIDY 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 126 INLFGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDTYYlkTVTSASNNETYCRSFYPeHSI 205
Cdd:cd15090  81 YNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVMFM--ATTKYRQGSIDCTLTFS-HPS 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 206 KEWLIGMELVSVVLGFAVPFSIIAVFYFLL------ARAISASSDQEKHSSR--KIIFSYVVVFLVCWLPYHVAVlldIF 277
Cdd:cd15090 158 WYWENLLKICVFIFAFIMPVLIITVCYGLMilrlksVRMLSGSKEKDRNLRRitRMVLVVVAVFIVCWTPIHIYV---II 234
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 31083344 278 SILHYIPftcrleHALFTAL--HVTQCLSLVHCCVNPVLYSFINRNYR 323
Cdd:cd15090 235 KALVTIP------ETTFQTVswHFCIALGYTNSCLNPVLYAFLDENFK 276
7tmA_P2Y10 cd15153
P2Y purinoceptor 10, member of the class A family of seven-transmembrane G protein-coupled ...
48-326 1.73e-27

P2Y purinoceptor 10, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y10 receptor is a G-protein coupled receptor that is activated by both sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA). Phylogenetic analysis of the class A GPCRs shows that P2Y10 is grouped into the cluster comprising nucleotide and lipid receptors. Although the mouse P2Y10 was found to be expressed in brain, lung, reproductive organs, and skeletal muscle, the physiological function of this receptor is not yet known. S1P and LPA are bioactive lipid molecules that induce a variety of cellular responses through G proteins: adhesion, invasion, cell migration and proliferation, among many others.


Pssm-ID: 320281 [Multi-domain]  Cd Length: 283  Bit Score: 109.50  E-value: 1.73e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  48 SFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVQHNqWPMGELTCKVTHLIFSIN 127
Cdd:cd15153   4 ATTYIIIFIPGLLANSAALWVLCRFISKKNKAIIFMINLAVADLAHVLSLPLRIHYYIQHT-WPFGRFLCLLCFYLKYLN 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 128 LFGSIFFLTCMSVDRYLsityFTNTPSSRKKMVRRV-VCI--LVWLLAFCVSLPdtYYLKTVTSASNNETYCRSFYPEHS 204
Cdd:cd15153  83 MYASICFLTCISIQRCF----FLLHPFKARDWKRRYdVGIsaAVWIVVGLACLP--FPLLRSKSLSNNNRSCFADLGMKK 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 205 IK-EWLIGMELVSVVLGFAVPFSIIAVFYFLLARAISASSDQ-----EKHSSRKIIFSYVVVFLVCWLPYHVAVLLDIFS 278
Cdd:cd15153 157 LNfGAAIAMMTVAELFGFVIPLFIIAWCTWKTENSLRQRNKQqqstsEKQKALRMVRMCAAVFFICFAPYHINFLFYLMV 236
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 31083344 279 ILHYIPfTCRLEHALFTALHVTQCLSLVHCCVNPVLYSFINRNYRYEL 326
Cdd:cd15153 237 SESIIT-NCEVSQVILQFHPISLCLASLNCCLDPILYYFMTSEFQDQL 283
7tmA_AstA_R_insect cd15096
allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G ...
45-330 2.10e-27

allatostatin-A receptor in insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled AstA receptor binds allatostatin A. Three distinct types of allatostatin have been identified in the insects and crustaceans: AstA, AstB, and AstC. They both inhibit the biosynthesis of juvenile hormone and exert an inhibitory influence on food intake. Therefore, allatostatins are considered as potential targets for insect control.


Pssm-ID: 320224 [Multi-domain]  Cd Length: 284  Bit Score: 108.92  E-value: 2.10e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  45 YTLSFIYIFIFVIGMIANSVVVWV---NIQAKTTgydTHCYILNLAIADL-WVVLTIPVWVVSLVQhNQWPMGELTCKVT 120
Cdd:cd15096   1 IVVPVIFGLIFIVGLIGNSLVILVvlsNQQMRST---TNILILNLAVADLlFVVFCVPFTATDYVL-PTWPFGDVWCKIV 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 121 HLIFSINLFGSIFFLTCMSVDRYLSITYFTNTPSSRKK--MVRRVVCILVWLLAFCVSLPDTYYLKTVTSASNNETYCRS 198
Cdd:cd15096  77 QYLVYVTAYASVYTLVLMSLDRYLAVVHPITSMSIRTErnTLIAIVGIWIVILVANIPVLFLHGVVSYGFSSEAYSYCTF 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 199 FYPEHSIKEwliGMELVSVVLGFAVPFSIIAVFYFLLARAI----------SASSDQEKHSSRKIIFSYVVVFLVCWLPY 268
Cdd:cd15096 157 LTEVGTAAQ---TFFTSFFLFSYLIPLTLICVLYMLMLRRLrrqkspggrrSAESQRGKRRVTRLVVVVVVVFAICWLPI 233
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 31083344 269 HVAVLLDIFSILHYIPFTcrlehalFTALHVTQCLSLVHCCVNPVLYSFINRNYRyelmKAF 330
Cdd:cd15096 234 HIILLLKYYGVLPETVLY-------VVIQILSNCLAYGNSCVNPILYAFLSQNFR----KAF 284
7tmA_P2Y11 cd15376
P2Y purinoceptor 11, member of the class A family of seven-transmembrane G protein-coupled ...
50-315 4.36e-27

P2Y purinoceptor 11, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y11 belongs to the P2Y receptor family of purinergic G-protein coupled receptors. The activation of P2Y11 is a major pathway of macrophage activation that leads to the release of cytokines. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320498 [Multi-domain]  Cd Length: 284  Bit Score: 108.24  E-value: 4.36e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  50 IYIFIFVIGMIANSVVVWVNIQAKTTGYDTH-CYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVTHLIFSINL 128
Cdd:cd15376   6 ILGVEFLVAVLGNGLALWLFVTRERRPWHTGvVFSFNLAVSDLLYALSLPLLAAYYYPPKNWRFGEAACKLERFLFTCNL 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 129 FGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPdTYYLKTVTSASNNETYCRSFYPEHSIKEW 208
Cdd:cd15376  86 YGSIFFITCISLNRYLGIVHPFFTRSHVRPKHAKLVSLAVWLLVAALSAP-VLSFSHLEVERHNKTECLGTAVDSRLPTY 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 209 LiGMELVSVVLGFAVPFSIIAVFYFLLARAISAS---SDQEKHSSRKIIFSYVVVFLVCWLPYHVAVLLDIFSILHYipF 285
Cdd:cd15376 165 L-PYSLFLAVVGCGLPFLLTLASYLAIVWAVLRSpgiTTLEKRKVAALVAVVVALYAVSFVPYHILRNLNLYRRLQW--L 241
                       250       260       270
                ....*....|....*....|....*....|
gi 31083344 286 TCRLEHALFTALHVTQCLSLVHCCVNPVLY 315
Cdd:cd15376 242 KAAASLRIYFAYQVTKGLVTLNMCIHPLLY 271
7tmA_PAR2 cd15370
protease-activated receptor 2, member of the class A family of seven-transmembrane G ...
47-323 5.76e-27

protease-activated receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 341349 [Multi-domain]  Cd Length: 280  Bit Score: 107.96  E-value: 5.76e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  47 LSFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVTHLIFSI 126
Cdd:cd15370   3 LPIVYIIVFVVGLPSNAMALWVFLFRTKKKHPAVIYMANLALADLLFVIWFPLKIAYHINGNNWIYGEALCKVLIGFFYG 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 127 NLFGSIFFLTCMSVDRYLSItyfTNTPSSRKKMVRRVVCI--LVWLLAFCVSLPDTYYLKTVTSASNNETYCRSFYPEHS 204
Cdd:cd15370  83 NMYCSILFMTCLSVQRYWVI---VNPMSHSRKKANIAIGIslAIWLLILLVTIPLYLVKQTVFIPALDITTCHDVLPEQL 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 205 IKEWLIGMELVSVVLGFAVPFSIIAVFYFLLARAISASSD-----QEKHSSRKIIFSYVVVFLVCWLPYHVAVlldifsI 279
Cdd:cd15370 160 LVGDMFNYFLSLAIGVFLFPAFLTAVAYVLMIRALKSSINdesieKKRKRAIKLIVTVLVMYLICFTPSNLLL------V 233
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 31083344 280 LHYIPFTCRLEHALFTALHVTQCLSLVHCCVNPVLYSFINRNYR 323
Cdd:cd15370 234 VHYFLLKNQGQSSVYAFYITALCLSTLNSCIDPFVYYFVSHDFR 277
7tmA_GPR31 cd15199
G protein-coupled receptor 31, member of the class A family of seven-transmembrane G ...
52-324 8.17e-27

G protein-coupled receptor 31, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR31, also known as 12-(S)-HETE receptor, is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid. Phylogenetic analysis showed that GPR31 and oxoeicosanoid receptor 1 (OXER1, GPR170) are the most closely related receptors to the hydroxycarboxylic acid receptor family (HCARs). GPR31, like OXER1, activates the ERK1/2 (MAPK3/MAPK1) pathway of intracellular signaling, but unlike the OXER1, does not cause increase in the cytosolic calcium level. GPR31 is also shown to activate NFkB. 12-(S)-HETE is a 12-lipoxygenase metabolite of arachidonic acid produced by mammalian platelets and tumor cells. It promotes tumor cells adhesion to endothelial cells and sub-endothelial matrix, which is a critical step for metastasis.


Pssm-ID: 320327 [Multi-domain]  Cd Length: 278  Bit Score: 107.57  E-value: 8.17e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  52 IFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVTHLIFSINLFGS 131
Cdd:cd15199   8 ILEFGLGLPGNAIALWTFIFRLKVWKPYAVYLLNLVLADVLLLICLPFKAYFYLNGNRWSLGGGTCKALLFMLSLSRGVS 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 132 IFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPdtyylKTVTSASNNETYCRSFYPEHSIKEWLIG 211
Cdd:cd15199  88 IAFLTAVALDRYFRVVHPRGKKNSLSLQAAPYISFLVWLLLVGLTIP-----TLLASQPKNFTECNSFSPKDDEDFSDTW 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 212 MELVSvVLGFAVPFSIIAVFYFLLARAISAS----SDQEK-HSSRKIIFSYVVVFLVCWLPYHVA-VLLDIFSILHyipf 285
Cdd:cd15199 163 QEAVF-FLQFLLPFGLIVFCTVRIIRRLKKRlrdvGKQPKlQRAMALVTSVVVVFGFCFLPCFLArVLMLIFQNKE---- 237
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 31083344 286 TCRLEHALFTALHVTQCLSLVHCCVNPVLYSFINRNYRY 324
Cdd:cd15199 238 SCNALNIAVHTYDVTMCLTYLNSVLDPIVYCFSSPTFRS 276
PHA02638 PHA02638
CC chemokine receptor-like protein; Provisional
51-330 1.78e-26

CC chemokine receptor-like protein; Provisional


Pssm-ID: 165021 [Multi-domain]  Cd Length: 417  Bit Score: 108.95  E-value: 1.78e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344   51 YIFIFVIGMIANSVVVWVNIQAKTTGYdTHCYILNLAIADLWVVLTIPVWVVSlvQHNQWPMGELTCKVTHLIFSINLFG 130
Cdd:PHA02638 105 YIIIFILGLFGNAAIIMILFCKKIKTI-TDIYIFNLAISDLIFVIDFPFIIYN--EFDQWIFGDFMCKVISASYYIGFFS 181
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  131 SIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDTYYLKT----VTSASNNETY----CRSFYPE 202
Cdd:PHA02638 182 NMFLITLMSIDRYFAILYPISFQKYRTFNIGIILCIISWILSLIITSPAYFIFEAsniiFSAQDSNETIsnyqCTLIEDN 261
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  203 HSIKEWLIG--MELVSVVLGFAVPFSIIAVFYFLLARAISASSDQEKHSSRKIIFSYVVVFLVCWLPYHVAVLldIFSIL 280
Cdd:PHA02638 262 EKNNISFLGriLQFEINILGMFIPIIIFAFCYIKIILKLKQLKKSKKTKSIIIVSIIIICSLICWIPLNIVIL--FATMY 339
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 31083344  281 HYIPFTCRL-EH-----ALFTALHVTQCLSLVHCCVNPVLYSFINRNYRYELMKAF 330
Cdd:PHA02638 340 SFKGFNSIIsEHicgfiKLGYAMMLAEAISLTHCCINPLIYTLIGENFRMHLLMIF 395
7tmA_GPR83 cd15389
G protein-coupled receptor 83, member of the class A family of seven-transmembrane G ...
47-326 1.93e-26

G protein-coupled receptor 83, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR83, also known as GPR72, is widely expressed in the brain, including hypothalamic nuclei which is involved in regulating energy balance and food intake. The hypothalamic expression of GPR83 is tightly regulated in response to nutrient availability and is decreased in obese mice. A recent study suggests that GPR83 has a critical role in the regulation of systemic energy metabolism via ghrelin-dependent and ghrelin-independent mechanisms. GPR83 shares a significant amino acid sequence identity with the tachykinin receptors, however its endogenous ligand is unknown.


Pssm-ID: 320511 [Multi-domain]  Cd Length: 285  Bit Score: 106.65  E-value: 1.93e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  47 LSFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVV-LTIPVWVVSLVQhNQWPMGELTCKVTHLIFS 125
Cdd:cd15389   3 LIVAYSIIIVISLFGNSLVCHVIFKNKRMHTATNLFIVNLAVSDILITlLNTPFTLVRFVN-STWVFGKIMCHLSRFAQY 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 126 INLFGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCIlvWLLAFCVSLPDTYYLKTVT---SASNNETYCRSFYPE 202
Cdd:cd15389  82 CSVYVSTLTLTAIALDRHRVILHPLKPRITPCQGVVVIAII--WIMASCLSLPHAIYQKLVEfeySNERTRSRCLPSFPE 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 203 HSIKEWLIgMELVSVVLGFAVPFSIIAVFYFLLAR------AISASSD-------QEKHSSRKIIFSYVVVFLVCWLPYH 269
Cdd:cd15389 160 PSDLFWKY-LDLATFILQYVLPLLIIGVAYTRVAKklwlrnAIGDVTTeqyvaqrRKKKKTIKMLMLVVLLFAICWLPLN 238
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 31083344 270 VAVLLdifsiLHYIPFtcRLEHALFTALHvtqCLSLVHCCVNPVLYSFINRNYRYEL 326
Cdd:cd15389 239 CYHVL-----LSSHPI--RSNSALFFAFH---WLAMSSTCYNPFIYCWLNDSFRSEL 285
7tmA_LPAR5 cd15154
lysophosphatidic acid receptor 5, member of the class A family of seven-transmembrane G ...
51-323 1.02e-25

lysophosphatidic acid receptor 5, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 5 (LPAR5) is a G protein-coupled receptor that binds the bioactive lipid lysophosphatidic acid (LPA) and is involved in maintenance of human hair growth. Phylogenetic analysis of the class A GPCRs shows that LAPR5 is classified into the cluster consisting receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production. Activation of LPAR5 is coupled to G(q) and G(12/13) proteins.


Pssm-ID: 320282 [Multi-domain]  Cd Length: 285  Bit Score: 104.46  E-value: 1.02e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  51 YIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVQHnQWPMGELTCKVTHLIFSINLFG 130
Cdd:cd15154   7 YSLLFPVGLLLNAVALWVFVRYLRLHSVVSIYMCNLALSDLLFTLSLPLRIYYYANH-YWPFGNFLCQFSGSIFQMNMYG 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 131 SIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDTYYLKTVTSASNNETYCRSFYP-EHSIKEWL 209
Cdd:cd15154  86 SCLFLMCINVDRYLAIVHPLRFRHLRRPKVARLLCLAVWALILGGSVPAAIVHSSSDCLLHGEKVYRCFESfSDNDWKGL 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 210 IGMELVSVVLGFAVPFSiiAVFY------FLLARAISASSdQEKHSSRKIIFSYVVVFLVCWLPYHVAVLLDIFSILHYI 283
Cdd:cd15154 166 LPLVVLAEILGFLLPLA--AVLYcscrifVELCRTQEPQQ-GRRRKTVRLLLVNLVIFLICFVPYNTTLAVYGLLRANLV 242
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 31083344 284 PFTCRLEHALFTALHVTQCLSLVHCCVNPVLYSFINRNYR 323
Cdd:cd15154 243 EDTWNIKDTLRKVLSVTVLLASTNCALDPLVYYFSTEGFR 282
7tmA_SUCNR1_GPR91 cd15378
succinate receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
45-323 2.10e-25

succinate receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Succinate receptor (SUCNR1) GPR91 exclusively couples to G(i) protein to inhibit cAMP production and also activates PLC-beta to increase intracellular calcium concentrations in an inositol phosphate dependent mechanism. Succinate, an intermediate molecule of the citric cycle, is shown to cause cardiac hypertrophy via GPR91 activation. Furthermore, succinate-induced GPR91 activation is involved in the regulation of renin-angiotensin system and is suggested to play an important role in the development of renovascular hypertension and diabetic nephropathy. SUCNR1 belongs to the class A GPCR superfamily and is phylogenetically related to the purinergic P2Y1-like receptor subfamily, whose members are coupled to G(q) protein to activate phospholipase C (PLC).


Pssm-ID: 320500 [Multi-domain]  Cd Length: 283  Bit Score: 103.64  E-value: 2.10e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  45 YTLSFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVqHNQWPMGELTCKVTHLIF 124
Cdd:cd15378   1 YYLPTMYSIEFVLGFIGNTIVILGYIFCLKNWKSSNIYLFNLSVSDLAFLCTLPMLVYSYS-NGQWLFGDFLCKSNRYLL 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 125 SINLFGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDTYYLKTVTsaSNNETYCRSFYPEHS 204
Cdd:cd15378  80 HANLYSSILFLTFISIDRYLLIKYPFREHILQKKRSAVAISLAIWVLVTLELLPILTFIGPNL--KDNVTKCKDYASSGD 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 205 IKEWLIgMELVSVVLGFAVPFSIIAVFYFLLARAISASSDQEKHSSR-----KIIFSYVVVFLVCWLPYHVAVLLDIFSI 279
Cdd:cd15378 158 ATNSLI-YSLFLTVTGFLIPLCVMCFFYYKIALFLKNRNRQLANATSfekplTLVILAVVIFSVLFTPYHVMRNVRIASR 236
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 31083344 280 LHYIPFTCRLEHALFTALHVTQCLSLVHCCVNPVLYSFINRNYR 323
Cdd:cd15378 237 LDSIGVSECTLIIIKSLYIVTRPIAFLNSVINPVFYFLMGDHFR 280
7tmA_GPR35_55-like cd15923
G protein-coupled receptor 35, GPR55, and similar proteins, member of the class A family of ...
50-323 3.62e-25

G protein-coupled receptor 35, GPR55, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily is composed of GPR35, GPR55, and similar proteins. GPR35 shares closest homology with GPR55, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A number of studies have suggested that GPR35 may play important physiological roles in hypertension, atherosclerosis, nociception, asthma, glucose homeostasis and diabetes, and inflammatory bowel disease. GPR35 is thought to be responsible for brachydactyly mental retardation syndrome, which is associated with a deletion comprising chromosome 2q37 in human, and is also implicated as a potential oncogene in stomach cancer. GPR35 couples to G(13) and G(i/o) proteins, whereas GPR55 has been reported to couple to G(13), G(12), or G(q) proteins. Activation of GPR55 leads to activation of phospholipase C, RhoA, ROCK, ERK, p38MAPK, and calcium release. Recently, lysophosphatidylinositol (LPI) has been identified as an endogenous ligand for GPR55, while several endogenous ligands for GPR35 have been identified including kynurenic acid, 2-oleoyl lysophosphatidic acid, and zaprinast.


Pssm-ID: 320589 [Multi-domain]  Cd Length: 273  Bit Score: 102.92  E-value: 3.62e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  50 IYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVQhnQWPMGELTCKVTHLIFSINLF 129
Cdd:cd15923   6 IYIPTFVLGLLLNILALWVFCWRLKKWTETNIYMTNLAVADLLLLISLPFKMHSYRR--ESAGLQKLCNFVLSLYYINMY 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 130 GSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPdtYYLktvTSASNNETYCRsfypEHSIKEWL 209
Cdd:cd15923  84 VSIFTITAISVDRYVAIRYPLRARELRSPRKAAVVCAVIWVLVVTISIP--YFL---LDSSNEKTMCF----QRTKQTES 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 210 IGMELVSVVLGFAVPFSIIA-----VFYFLLARAISASSDQEKHSSRKIIFSYVVVFLVCWLPYHVAVLLDIFSILHYip 284
Cdd:cd15923 155 LKVFLLLEIFGFLLPLIIMTfcsarVIHTLQKRLDDVGSRSETKQCIRVIMANLIVFIVCFLPVHVGFFVKFIVGKSY-- 232
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 31083344 285 fTCRLEHALFTALHVTQCLSLVHCCVNPVLYSFINRNYR 323
Cdd:cd15923 233 -SCDSKLIIHFFLQSAFCLSDMNCCLDAFCYYFATKEFR 270
7tmA_capaR cd15134
neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of ...
47-323 3.91e-25

neuropeptide capa receptor and similar invertebrate proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; CapaR is a G-protein coupled receptor for the Drosophila melanogaster capa neuropeptides (Drm-capa-1 and -2), which act on the Malpighian tubules to increase fluid transport. The capa peptides are evolutionarily related to vertebrate Neuromedin U neuropeptide and contain a C-terminal FPRXamide motif. CapaR regulates fluid homeostasis through its ligands, thereby acts as a desiccation stress-responsive receptor. CapaR undergoes desensitization, with internalization mediated by beta-arrestin-2.


Pssm-ID: 320262 [Multi-domain]  Cd Length: 298  Bit Score: 103.18  E-value: 3.91e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  47 LSFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADL-WVVLTIPVWVVSLVQHNQWPMGELTCKVTHLIFS 125
Cdd:cd15134   3 ITIIYGIIFVTGVVGNLCTCIVIARNRSMHTATNYYLFSLAVSDLlLLILGLPFELYTIWQQYPWVFGEVFCKLRAFLSE 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 126 INLFGSIFFLTCMSVDRYLSITY--FTNTPSSRKKMVRRVVCIlvWLLAFCVSLP-----DTYYLK---TVTSASNNETY 195
Cdd:cd15134  83 MSSYASVLTITAFSVERYLAICHplRSHTMSKLSRAIRIIIAI--WIIAFVCALPfaiqtRIVYLEyppTSGEALEESAF 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 196 CRSFYPEHSIKEWLIgmelVSVVLGFAVPFSIIAVFYFLLARAISASSDQEK-----------HSSRKIIF----SYVVV 260
Cdd:cd15134 161 CAMLNEIPPITPVFQ----LSTFLFFIIPMIAIIVLYVLIGLQLRRSTLLRRgqrsvsggrrsSQSRRTVLrmlvAVVVA 236
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 31083344 261 FLVCWLPYHVAVLLDIFsILHYIPFTCRLEHALFtalHVTQCLSLVHCCVNPVLYSFINRNYR 323
Cdd:cd15134 237 FFICWAPFHAQRLLTVY-AKNMTPPYLFINRILF---YISGVLYYVSSTVNPILYNVMSAKYR 295
7tmA_Delta_opioid_R cd15089
opioid receptor subtype delta, member of the class A family of seven-transmembrane G ...
46-323 4.14e-25

opioid receptor subtype delta, member of the class A family of seven-transmembrane G protein-coupled receptors; The delta-opioid receptor binds the endogenous pentapeptide ligands such as enkephalins and produces antidepressant-like effects. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320217 [Multi-domain]  Cd Length: 281  Bit Score: 102.72  E-value: 4.14e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  46 TLSFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVQHNqWPMGELTCKVTHLIFS 125
Cdd:cd15089   2 AITALYSVVCVVGLLGNVLVMYGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMET-WPFGELLCKAVLSIDY 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 126 INLFGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDTYYLKTVTSASnNETYCRSFYPEHSI 205
Cdd:cd15089  81 YNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLSSGVGVPIMVMAVTKTPRD-GAVVCMLQFPSPSW 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 206 KeWLIGMELVSVVLGFAVPFSIIAVFYFLL------ARAISASSDQEKHSSR--KIIFSYVVVFLVCWLPYHvavlldIF 277
Cdd:cd15089 160 Y-WDTVTKICVFIFAFVVPILVITVCYGLMilrlrsVRLLSGSKEKDRNLRRitRMVLVVVAAFIICWTPIH------IF 232
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 31083344 278 SILHYIPFTCRLEHALFTALHVTQCLSLVHCCVNPVLYSFINRNYR 323
Cdd:cd15089 233 VIVWTLVDIDRRNPLVVAALHLCIALGYANSSLNPVLYAFLDENFK 278
7tmA_NTSR-like cd14979
neurotensin receptors and related G protein-coupled receptors, member of the class A family of ...
45-323 5.39e-25

neurotensin receptors and related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the neurotensin receptors and related G-protein coupled receptors, including neuromedin U receptors, growth hormone secretagogue receptor, motilin receptor, the putative GPR39 and the capa receptors from insects. These receptors all bind peptide hormones with diverse physiological effects. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320110 [Multi-domain]  Cd Length: 300  Bit Score: 102.82  E-value: 5.39e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  45 YTLSFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWV-VLTIPVWVVSLVQHNQWPMGELTCKVTHLI 123
Cdd:cd14979   1 VLVTAIYVAIFVVGIVGNLLTCIVIARHKSLRTTTNYYLFSLAVSDLLIlLVGLPVELYNFWWQYPWAFGDGGCKLYYFL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 124 FSINLFGSIFFLTCMSVDRYLSITY-FTNTPSSRKKMVRRVVcILVWLLAFCVSLPDTYYLKTVT-SASNNET-----YC 196
Cdd:cd14979  81 FEACTYATVLTIVALSVERYVAICHpLKAKTLVTKRRVKRFI-LAIWLVSILCAIPILFLMGIQYlNGPLPGPvpdsaVC 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 197 RSFYPEHSIKewlIGMElVSVVLGFAVPFSIIAVFYFLLARAI-------------------SASSDQEKHSSRKIIFSY 257
Cdd:cd14979 160 TLVVDRSTFK---YVFQ-VSTFIFFVLPMFVISILYFRIGVKLrsmrnikkgtraqgtrnveLSLSQQARRQVVKMLGAV 235
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 31083344 258 VVVFLVCWLPYHVAVLldIFSilhYIPFTCRLEHALFTALH-VTQCLSLVHCCVNPVLYSFINRNYR 323
Cdd:cd14979 236 VIAFFVCWLPFHAQRL--MFS---YASKEDTFLFDFYQYLYpISGILFYLSSAINPILYNLMSSRFR 297
7tmA_PAR3 cd15371
protease-activated receptor 3, member of the class A family of seven-transmembrane G ...
50-320 7.79e-25

protease-activated receptor 3, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320493 [Multi-domain]  Cd Length: 274  Bit Score: 101.80  E-value: 7.79e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  50 IYIFIFVIGMIANSVVVWVnIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVTHLIFSINLF 129
Cdd:cd15371   6 VYIIVVVLGVPSNAIILWM-LFFRLRSVCTAIFYANLAISDLLFCITLPFKIVYHLNGNNWVFGETMCRIITITFYGNMY 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 130 GSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLP-----DTYYLKTVtsasnNETYCRSFYPEHS 204
Cdd:cd15371  85 CSILLLTCISINRYLAIVHPFIYRSLPKKTYAVLICALVWTIVFLYMLPffilkQTYYLKEL-----NITTCHDVLPECE 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 205 IKEWLIGMELVS-VVLGFAVPFSIIAVFYFLLARAISAsSDQEKHSSRKIIFSYVVVFLVCWLPYHVAVlldifsILHYI 283
Cdd:cd15371 160 QNSNFQFYYFISmAVFGFLIPLVITIFCYISIIRTLNA-YEHKWFWYVKITALVLIIFTICFAPSNVIL------IIHHF 232
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 31083344 284 PFTCRLEHALFTALHVTQCLSLVHCCVNPVLYSFINR 320
Cdd:cd15371 233 NYYYFNNDNLYSIYLIALCLGSLNSCLDPFLYFLMSK 269
7tmA_TACR_family cd14992
tachykinin receptor and closely related proteins, member of the class A family of ...
51-323 1.41e-24

tachykinin receptor and closely related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes G-protein coupled receptors for a variety of neuropeptides of the tachykinin (TK) family as well as closely related receptors. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320123 [Multi-domain]  Cd Length: 291  Bit Score: 101.36  E-value: 1.41e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  51 YIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVTHLIFSINLFG 130
Cdd:cd14992   7 LVVIILVSVVGNFIVIAALARHKNLRGATNYFIASLAISDLLMALFCTPFNFTYVVSLSWEYGHFLCKIVNYLRTVSVYA 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 131 SIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDTYYLKTVTSASN---NETYCRSFyPEHSIKE 207
Cdd:cd14992  87 SSLTLTAIAFDRYFAIIHPLKPRHRQSYTTTVIIIITIWVVSLLLAIPQLYYATTEVLFSVknqEKIFCCQI-PPVDNKT 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 208 WLIGMELVSVVLGFAVPFSIIAVFYFLLAR----------AISASSDQEKHSSRKIIFSYVVV---FLVCWLPYHvavll 274
Cdd:cd14992 166 YEKVYFLLIFVVIFVLPLIVMTLAYARISRelwfrkvpgfSIKEVERKRLKCKRRVIKMLVCVvvlFVICWLPFH----- 240
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 31083344 275 dIFSILHYIPFTCRLEHALFTALHVTQCLSLVHCCVNPVLYSFINRNYR 323
Cdd:cd14992 241 -LFFLLRDFFPLIMKEKHTLQVYYFLHWIAMSNSMYNPIIYVTLNNNFR 288
7tmA_NOFQ_opioid_R cd15092
nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G ...
46-323 1.52e-24

nociceptin/orphanin FQ peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The nociceptin (NOP) receptor binds nociceptin or orphanin FQ, a 17 amino acid endogenous neuropeptide. The NOP receptor is involved in the modulation of various brain activities including instinctive and emotional behaviors. The opioid receptor family is composed of four major subtypes: mu (MOP), delta (DOP), kappa (KOP) opioid receptors, and the nociceptin/orphanin FQ peptide receptor (NOP). They are distributed widely in the central nervous system and respond to classic alkaloid opiates, such as morphine and heroin, as well as to endogenous peptide ligands, which include dynorphins, enkephalins, endorphins, endomorphins, and nociceptin. Opioid receptors are coupled to inhibitory G proteins of the G(i/o) family and involved in regulating a variety of physiological functions such as pain, addiction, mood, stress, epileptic seizure, and obesity, among many others.


Pssm-ID: 320220 [Multi-domain]  Cd Length: 279  Bit Score: 101.10  E-value: 1.52e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  46 TLSFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVQhNQWPMGELTCKVTHLIFS 125
Cdd:cd15092   2 TIVVVYLIVCVVGLVGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDIFL-GFWPFGNALCKTVIAIDY 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 126 INLFGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPdtYYLKTVTSASNNETYCRSFYPEhSI 205
Cdd:cd15092  81 YNMFTSTFTLTAMSVDRYVAICHPIKALDVRTPHKAKVVNVCIWALASVVGVP--VMVMGSAQVEDEEIECLVEIPT-PQ 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 206 KEWLIGMELVSVVLGFAVPFSIIAVFYFLL------ARAISASSDQEKHSSR--KIIFSYVVVFLVCWLPyhvavlLDIF 277
Cdd:cd15092 158 DYWDPVFGICVFLFSFIIPVLIISVCYSLMirrlrgVRLLSGSKEKDRNLRRitRLVLVVVAVFVGCWTP------IQIF 231
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 31083344 278 SILHYIPFTCRLEHALfTALHVTQCLSLVHCCVNPVLYSFINRNYR 323
Cdd:cd15092 232 VLAQGLGVQPSSETAV-AILRFCTALGYVNSSLNPVLYAFLDENFK 276
7tmA_GPER1 cd14989
G protein-coupled estrogen receptor 1, member of the class A family of seven-transmembrane G ...
47-326 5.56e-24

G protein-coupled estrogen receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled estrogen receptor 1 (GPER1), also known as the G-protein coupled receptor 30 (GPR30), is a high affinity receptor for estrogen. This receptor is a member of the class A of seven-transmembrane GPCRs. Estrogen binding results in intracellular calcium mobilization and synthesis of phosphatidylinositol (3,4,5)-trisphosphate in the nucleus. GPR30 plays an important role in development of tamoxifen resistance in breast cancer cells. The distribution of GPR30 is well established in the rodent, with high expression observed in the hypothalamus, pituitary gland, adrenal medulla, kidney medulla and developing follicles of the ovary. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320120 [Multi-domain]  Cd Length: 276  Bit Score: 99.51  E-value: 5.56e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  47 LSFIY-IFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLvqHNQWPMGELTCKVTHLIFS 125
Cdd:cd14989   2 LSCLYtIFLFPIGFIGNILILVVNLSFREKMTIPDLYFVNLAVADLILVADSLIEVFNL--NEKYYDIAVLCTFMSLFLQ 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 126 INLFGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLpdTYYLKTVTSASNNETYCRSFYPEhsi 205
Cdd:cd14989  80 INMYSSIFFLTWMSFDRYIALAKVMKSSPLRTMQHARLSCGLIWMASISATL--LPFTAVQAQHTGEVHFCFADVRE--- 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 206 KEWLigmelvSVVLGFAVPFSIIAVFYFLLARAISASSDQEKHSSR-----KIIFSYVVVFLVCWLPYHVAV----LLDI 276
Cdd:cd14989 155 IQWL------EVTLGFIIPFSIIGLCYSLIVRVLVRAQKHRRLRPRrqkalRMILVVVLVFFICWLPENVFIsiqlLQGT 228
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 31083344 277 FSILHYIPFTCRLEHALFTalHVTQCLSLVHCCVNPVLYSFINRNYRYEL 326
Cdd:cd14989 229 QEPSESYDESFRHNHPLTG--HIVNLAAFSNSCLNPLIYSFLGETFRDKL 276
7tmA_Gal2_Gal3_R cd15097
galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G ...
47-323 1.22e-23

galanin receptor subtypes 2 and 3, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled galanin receptors bind galanin, a neuropeptide that is widely expressed in the brain, peripheral tissues, and endocrine glands. Three receptors subtypes have been so far identified: GAL1, GAL2, and GAL3. The specific functions of each subtype remains mostly unknown, although galanin is thought to be involved in a variety of neuronal functions such as hormone release and food intake. Galanin is implicated in numerous neurological and psychiatric diseases including Alzheimer's disease, depression, eating disorders, epilepsy and stroke, among many others.


Pssm-ID: 320225 [Multi-domain]  Cd Length: 279  Bit Score: 98.74  E-value: 1.22e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  47 LSFIYIFIFVIGMIANSVVVWVNIQAKTTGYDT-HCYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVTHLIFS 125
Cdd:cd15097   3 VPVVFSLIFLLGTVGNSLVLAVLLRSGQSGHNTtNLFILNLSVADLCFILFCVPFQATIYSLEGWVFGSFLCKAVHFFIY 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 126 INLFGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDTYYLKTVTSAsnNETYCRSFYPEHSI 205
Cdd:cd15097  83 LTMYASSFTLAAVSVDRYLAIRYPLRSRELRTPRNAVAAIALIWGLSLLFAGPYLSYYDLIDYA--NSTVCMPGWEEARR 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 206 KewliGMELVSVVLGFAVPFSIIAVFYF----LLARAISASSDQE-----KHSSRKIIFSYVVVFLVCWLPYHVAVLLDI 276
Cdd:cd15097 161 K----AMDTCTFAFGYLIPVLVVSLSYTrtikYLWTAVDPLEAMSeskraKRKVTKMIIIVTALFCLCWLPHHVVILCYL 236
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 31083344 277 FSILHYIPFT--CRLehalftalhVTQCLSLVHCCVNPVLYSFINRNYR 323
Cdd:cd15097 237 YGDFPFNQATyaFRL---------LSHCMAYANSCLNPIVYALVSKHFR 276
7tmA_PD2R2_CRTH2 cd15118
prostaglandin D2 receptor, member of the class A family of seven-transmembrane G ...
56-317 1.50e-23

prostaglandin D2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin D2 receptor, also known as CRTH2, is a chemoattractant G-protein coupled receptor expressed on T helper type 2 cells that binds prostaglandin D2 (PGD2). PGD2 functions as a mast cell-derived mediator to trigger asthmatic responses and also causes vasodilation. PGD2 exerts its inflammatory effects by binding to two G-protein coupled receptors, the D-type prostanoid receptor (DP) and PD2R2 (CRTH2). PD2R2 couples to the G protein G(i/o) type which leads to a reduction in intracellular cAMP levels and an increase in intracellular calcium. PD2R2 is involved in mediating chemotaxis of Th2 cells, eosinophils, and basophils generated during allergic inflammatory processes. CRTH2 (PD2R2), but not DP receptor, undergoes agonist-induced internalization which is one of key processes that regulates the signaling of the GPCR.


Pssm-ID: 320246 [Multi-domain]  Cd Length: 284  Bit Score: 98.72  E-value: 1.50e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  56 VIGMIANSVVVWVnIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVTHLIFSINLFGSIFFL 135
Cdd:cd15118  12 TLGIVENLLILWV-VGFRLRRTVISIWILNLALSDLLATLSLPFFTYYLASGHTWELGTTFCRIHSSIFFLNMFVSGFLL 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 136 TCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPdTYYLKTVTSASNNETYCRSFYPEHS---------IK 206
Cdd:cd15118  91 AAISLDRCLLVVKPVWAQNHRNVAAAKKICGVIWAMALINTIP-YFVFRDVIERKDGRKLCYYNFALFSpspdnnhpiCK 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 207 EWLIGMELVSVVLGFAVPFSIIAVFYFLLARAISASSDQEKHSSRKIIFSYVVVFLVCWLPYHVAVLLDIFSilhyiPFT 286
Cdd:cd15118 170 QRQEGLAISKLLLAFLIPLVIIAVSYAVVSLIIRHRCRRRPGRFVRLVVSVVVSFALCWAPYHIFSIIEVMA-----HNQ 244
                       250       260       270
                ....*....|....*....|....*....|.
gi 31083344 287 CRLEHALFTALHVTQCLSLVHCCVNPVLYSF 317
Cdd:cd15118 245 HSLRPLVIQGLPFATTLAFLNSVLNPVLYVF 275
7tmA_Opsins_type2_animals cd14969
type 2 opsins in animals, member of the class A family of seven-transmembrane G ...
45-323 1.75e-23

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.


Pssm-ID: 381741 [Multi-domain]  Cd Length: 284  Bit Score: 98.43  E-value: 1.75e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  45 YTLSFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWV-VLTIPVWVVSLVqHNQWPMGELTCKVTHLI 123
Cdd:cd14969   1 YVLAVYLSLIGVLGVVLNGLVIIVFLKKKKLRTPLNLFLLNLALADLLMsVVGYPLSFYSNL-SGRWSFGDPGCVIYGFA 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 124 FSINLFGSIFFLTCMSVDRYLSITY-FTNTPSSRKKMVrrVVCILVWLLAFCVSLP-----DTYYLktvtsasnnETYCR 197
Cdd:cd14969  80 VTFLGLVSISTLAALAFERYLVIVRpLKAFRLSKRRAL--ILIAFIWLYGLFWALPplfgwSSYVP---------EGGGT 148
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 198 SFYPEHSIKEW-----LIGMelvsVVLGFAVPFSIIAVFYFLLARAISASSDQEKHSSR---------------KIIFSY 257
Cdd:cd14969 149 SCSVDWYSKDPnslsyIVSL----FVFCFFLPLAIIIFCYYKIYRTLRKMSKRAARRKNsaitkrtkkaekkvaKMVLVM 224
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 31083344 258 VVVFLVCWLPYHVAVLLDIFSILHYIPftcrlehalFTALHVTQCLSLVHCCVNPVLYSFINRNYR 323
Cdd:cd14969 225 IVAFLIAWTPYAVVSLYVSFGGESTIP---------PLLATIPALFAKSSTIYNPIIYVFMNKQFR 281
7tmA_GPR174-like cd15152
putative purinergic receptor GPR174, member of the class A family of seven-transmembrane G ...
51-326 2.97e-23

putative purinergic receptor GPR174, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR174 has been recently identified as a lysophosphatidylserine receptor that enhances intracellular cAMP formation by coupling to a G(s) protein. GPR174 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320280 [Multi-domain]  Cd Length: 282  Bit Score: 97.87  E-value: 2.97e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  51 YIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVqHNQWPMGELTCKVTHLIFSINLFG 130
Cdd:cd15152   7 YTVILIPGLIGNVLALWVFYAYVKETKRAVIFMINLAIADLLQVLSLPLRIFYYL-NKSWPFGKFLCMFCFYLKYVNMYA 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 131 SIFFLTCMSVDRYLSITYFTNTpSSRKKMVRRVVCILVWLLAFCVSLPdtyYLKTVTSASNNETYCRSFYPEHSIKEWL- 209
Cdd:cd15152  86 SIYFLVCISVRRCLYLIYPFRY-NDCKRKCDVYISIAGWLVVCVGCLP---FPLLRQSQDTNPTCCFADLPLRNVGLTTs 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 210 IGMELVSVVLGFAVPFSIIAVFYFLLARAI----SASSDQ-EKHSSRKIIFSYVVVFLVCWLPYHVAVLLDIFSILHYIP 284
Cdd:cd15152 162 VIMLTIAELTGFVTPLLIVLYCSWKTVMSLrektPVLQDLgEKKKALKMILTCAVVFLICFAPYHISFPLDFLVKSNKIK 241
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 31083344 285 fTCRLEHALFTALHVTQCLSLVHCCVNPVLYSFINRNYRYEL 326
Cdd:cd15152 242 -SCTARKVILIFHPVALCLASLNSCLDPVIYYFTTDEFKRRL 282
7tmA_GHSR-like cd15928
growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the ...
50-326 4.03e-23

growth hormone secretagogue receptor, motilin receptor, and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes growth hormone secretagogue receptor (GHSR or ghrelin receptor), motilin receptor (also called GPR38), and related proteins. Both GHSR and GPR38 bind peptide hormones. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin is also called the hunger hormone and is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. Motilin, the ligand for GPR38, is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. It is involved in the regulation of digestive tract motility.


Pssm-ID: 320594 [Multi-domain]  Cd Length: 288  Bit Score: 97.56  E-value: 4.03e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  50 IYIFIFVIGMIANSV---VVWVNIQAKTTgydTHCYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVTHLIFSI 126
Cdd:cd15928   6 VCSVLMLVGASGNLLtvlVIGRSRDMRTT---TNLYLSSLAVSDLLIFLVLPLDLYRLWRYRPWRFGDLLCRLMYFFSET 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 127 NLFGSIFFLTCMSVDRYLSITYftntPSSRKKMVRR----VVCILVWLLAFCVSLPDTYYLKTVTSASNNETYCRSFYPE 202
Cdd:cd15928  83 CTYASILHITALSVERYLAICH----PLRAKVLVTRgrvkLLIAVIWAVAIVSAGPALVLVGVEHIQGQQTPRGFECTVV 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 203 HSIKEWLIGMELVSVVLgFAVPFSIIAVFYFLLARAISASS-----------DQEKHSSRKIIFSYVVVFLVCWLPYHVA 271
Cdd:cd15928 159 NVSSGLLSVMLWVSTSF-FFVPMVCLSLLYGLIGRALWDRRqrsrtagasrrDNNHRQTVRMLAVIVLAFVLCWLPFHVG 237
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 272 VLLDIFSI-----LHYIPFTCRLehalftalhVTQCLSLVHCCVNPVLYSFINRNYRYEL 326
Cdd:cd15928 238 RVIFNHSRastkhLHYVSQYFNL---------VSFVLFYLSAAINPILYNLMSKRYRYAV 288
7tmA_GPR33 cd15120
orphan receptor GPR33, member of the class A family of seven-transmembrane G protein-coupled ...
55-323 7.32e-23

orphan receptor GPR33, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor GPR33, an orphan member of the chemokine-like receptor family, was originally identified as a pseudogene in humans as well as in several apes and rodent species. Although the intact GPR33 allele is still present in a small fraction of the human population, the human GPR33 contains a premature stop codon. The amino acid sequence of GPR33 shares a high degree of sequence identity with the members of the chemokine and chemoattractant receptors that control leukocyte chemotaxis. The human GPR33 is expressed in spleen, lung, heart, kidney, pancreas, thymus, gonads, and leukocytes.


Pssm-ID: 320248 [Multi-domain]  Cd Length: 282  Bit Score: 96.77  E-value: 7.32e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  55 FVIGMIANSVVVWVnIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVTHLIFSINLFGSIFF 134
Cdd:cd15120  11 FLVGLVVNGLYLWV-LGFKMRRTVNTLWFLHLILSNLIFTLILPFMAVHVLMDNHWAFGTVLCKVLNSTLSVGMFTSVFL 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 135 LTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDTYYLKTvTSASNNETYCRSFY---------PEHSI 205
Cdd:cd15120  90 LTAISLDRYLLTLHPVWSRQHRTNRWASAIVLGVWISAILLSIPYLAFRET-RLDEKGKTICQNNYalstnwesaEVQAS 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 206 KEWL-IGMELVSVVLGFAVPFSIIAVFYFLLARAISASSDQEKHSSRKIIFSYVVVFLVCWLPYHVAVLLDIFSILHYIP 284
Cdd:cd15120 169 RQWIhVAMFVFRFLLGFLLPFLIITFCYVRMALKMKERGLARSSKPFKVMFTAVVSFFVCWLPYHLHSGLVLTRGRPPSL 248
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 31083344 285 ftcrlehaLFTALHVTQCLSLVHCCVNPVLYSFINRNYR 323
Cdd:cd15120 249 --------TDITLLLTVGTTCFNTCFTPVLYLFVGENFK 279
7tmA_GPRnna14-like cd15001
GPRnna14 and related proteins, member of the class A family of seven-transmembrane G ...
49-323 8.24e-23

GPRnna14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the orphan G-protein coupled receptor GPRnna14 found in body louse (Pediculus humanus humanus) as well as its closely related proteins of unknown function. These receptors are members of the class A rhodopsin-like G-protein coupled receptors. As an obligatory parasite of humans, the body louse is an important vector for human diseases, including epidemic typhus, relapsing fever, and trench fever. GPRnna14 shares significant sequence similarity with the members of the neurotensin receptor family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320132 [Multi-domain]  Cd Length: 266  Bit Score: 96.19  E-value: 8.24e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  49 FIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLT-IPVWVVSLVQHNqWPMGELTCKVTHLIFSIN 127
Cdd:cd15001   4 IVYVITFVLGLIGNSLVIFVVARFRRMRSVTNVFLASLATADLLLLVFcVPLKTAEYFSPT-WSLGAFLCKAVAYLQLLS 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 128 LFGSIFFLTCMSVDRYLSITYFTNTPS-SRKKMVRRVVcILVWLLAFCVSLPDTYYLKTVTSASNNETYCRSFYPEHSIK 206
Cdd:cd15001  83 FICSVLTLTAISIERYYVILHPMKAKSfCTIGRARKVA-LLIWILSAILASPVLFGQGLVRYESENGVTVYHCQKAWPST 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 207 EWLIGMELVSVVLGFAVPFSIIAVFYfllaraisaSSDQEKhSSRKIIFSYVVVFLVCWLP---YHVAVLLDIFSILHYi 283
Cdd:cd15001 162 LYSRLYVVYLAIVIFFIPLIVMTFAY---------ARDTRK-QVIKMLISVVVLFAVCWGPlliDNLLVSFDVISTLHT- 230
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 31083344 284 pftcRLEHALFTALHvtqCLSLVHCCVNPVLYSFINRNYR 323
Cdd:cd15001 231 ----QALKYMRIAFH---LLSYANSCINPIIYAFMSKNFR 263
7tmA_GnRHR-like cd15195
gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A ...
50-323 1.23e-22

gonadotropin-releasing hormone and adipokinetic hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Gonadotropin-releasing hormone (GnRH) and adipokinetic hormone (AKH) receptors share strong sequence homology to each other, suggesting that they have a common evolutionary origin. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flying, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320323 [Multi-domain]  Cd Length: 293  Bit Score: 96.31  E-value: 1.23e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  50 IYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVL-TIP---VWVVSLvqhnQWPMGELTCKVTHLIFS 125
Cdd:cd15195   6 VTWVLFVISAAGNLTVLIQLFRRRRAKSHIQILIMHLALADLMVTFfNMPmdaVWNYTV----EWLAGDLMCRVMMFLKQ 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 126 INLFGSIFFLTCMSVDRYLSITyftnTPSSRKKMVRRVVCILV--WLLAFCVSLPDTYYLKTVTSASNNETY--CRSFYP 201
Cdd:cd15195  82 FGMYLSSFMLVVIALDRVFAIL----SPLSANQARKRVKIMLTvaWVLSALCSIPQSFIFSVLRKMPEQPGFhqCVDFGS 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 202 EHSIKEWLIgMELVSVVLGFAVPFSIIAVFYFLLARAISASSDQEKHSS-----------------RKIIFSYVVV--FL 262
Cdd:cd15195 158 APTKKQERL-YYFFTMILSFVIPLIITVTCYLLILFEISKMAKRARDTPisnrrrsrtnslerarmRTLRMTALIVltFI 236
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 31083344 263 VCWLPYHVAVLLDIFSILHYIPFTCRLEHALFTalhvtqcLSLVHCCVNPVLYSFINRNYR 323
Cdd:cd15195 237 VCWGPYYVLGLWYWFDKESIKNLPPALSHIMFL-------LGYLNPCLHPIIYGVFMKEIR 290
7tmA_GPR35-like cd15164
G protein-coupled receptor 35 and similar proteins, member of the class A family of ...
49-320 1.84e-22

G protein-coupled receptor 35 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR35 shares closest homology with GPR55, and they belong to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A number of studies have suggested that GPR35 may play important physiological roles in hypertension, atherosclerosis, nociception, asthma, glucose homeostasis and diabetes, and inflammatory bowel disease. GPR35 is thought to be responsible for brachydactyly mental retardation syndrome, which is associated with a deletion comprising chromosome 2q37 in human, and is also implicated as a potential oncogene in stomach cancer. Several endogenous ligands for GPR35 have been identified including kynurenic acid, 2-oleoyl lysophosphatidic acid, and zaprinast. GPR35 couples to G(13) and G(i/o) proteins.


Pssm-ID: 320292 [Multi-domain]  Cd Length: 272  Bit Score: 95.41  E-value: 1.84e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  49 FIYIFIFVIGMIANSVVVWV---NIQAKTtgyDTHCYILNLAIADLWVVLTIPVwvVSLVQHNQWPMGELtCKVTHLIFS 125
Cdd:cd15164   5 IIYIPILFFGLLFNVLALWVfccKMKKWT---ETRVYMINLAVADCCLLFSLPF--VLYFLKHSWPDDEL-CLVLQSIYF 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 126 INLFGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFC-VSLPdtyylktVTSASNNETYC-RSFYPEH 203
Cdd:cd15164  79 INRYMSIYIITAIAVDRYIAIKYPLKAKSLRSPRKAALTCGLLWVLVIIsVSLR-------LAWEEQEENFCfGKTSTRP 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 204 SIKewligmELVSVVLGFAVPFSI-----IAVFYFLLARAISASSDQEK-HSSRKIIFSYVVVFLVCWLPYHVAVLLDIf 277
Cdd:cd15164 152 SKR------TLIFSLLGFFIPLIIlsfcsIQVIRSLKKKKKTNPHEEKLiQKAIYIVSANLIVFIVCFLPLHIGLLVRF- 224
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 31083344 278 sILHYIPFTCRLEHALFTALHVTQCLSLVHCCVNPVLYSFINR 320
Cdd:cd15164 225 -VMESNKASCSLIQNIRNFIYVASCLANANCCLDAICYYFVAK 266
PHA02834 PHA02834
chemokine receptor-like protein; Provisional
45-323 1.89e-22

chemokine receptor-like protein; Provisional


Pssm-ID: 165177  Cd Length: 323  Bit Score: 96.13  E-value: 1.89e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344   45 YTLSFIYIFIFVIGMIANSVVVWVNIqAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVqhNQWPMGELTCKVTHLIF 124
Cdd:PHA02834  29 YFVIVFYILLFIFGLIGNVLVIAVLI-VKRFMFVVDVYLFNIAMSDLMLVFSFPFIIHNDL--NEWIFGEFMCKLVLGVY 105
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  125 SINLFGSIFFLTCMSVDRYLSITYFTNTpSSRKKMVRRVVCILVWLLAFCVSLPdTYYLKTVTSASNNETYCrsFYPEHS 204
Cdd:PHA02834 106 FVGFFSNMFFVTLISIDRYILVVNATKI-KNKSISLSVLLSVAAWVCSVILSMP-AMVLYYVDNTDNLKQCI--FNDYHE 181
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  205 IKEWLIGMELVSVVLGFAVPFSIIAVFYFLLARAISASSDQEKHSSRKIIFSYVVVFLVCWLPYHVAVLLDIFSILHYIP 284
Cdd:PHA02834 182 NFSWSAFFNFEINIFGIVIPLIILIYCYSKILYTLKNCKNKNKTRSIKIILTVVTFTVVFWVPFNIVLFINSLQSVGLID 261
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 31083344  285 FTCRLEHALFTALHVTQCLSLVHCCVNPVLYSFINRNYR 323
Cdd:PHA02834 262 IGCYHFKKIVYSIDIAELISFVHCCVNPIIYAFVGKNFK 300
7tmA_Vasopressin-like cd14986
vasopressin receptors and its related G protein-coupled receptors, member of the class A ...
54-326 2.47e-22

vasopressin receptors and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this group form a subfamily within the class A G-protein coupled receptors (GPCRs), which includes the vasopressin and oxytocin receptors, the gonadotropin-releasing hormone receptors (GnRHRs), the neuropeptide S receptor (NPSR), and orphan GPR150. These receptors share significant sequence homology with each other, suggesting that they have a common evolutionary origin. Vasopressin, also known as arginine vasopressin or anti-diuretic hormone, is a neuropeptide synthesized in the hypothalamus. The actions of vasopressin are mediated by the interaction of this hormone with three tissue-specific subtypes: V1AR, V1BR, and V2R. Although vasopressin differs from oxytocin by only two amino acids, they have divergent physiological functions. Vasopressin is involved in regulating osmotic and cardiovascular homeostasis, whereas oxytocin plays an important role in the uterus during childbirth and in lactation. GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR has also been associated with asthma and allergy. GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors.


Pssm-ID: 320117 [Multi-domain]  Cd Length: 295  Bit Score: 95.52  E-value: 2.47e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  54 IFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWV----VLTIPVWVVSlvqhNQWPMGELTCKVTHLIFSINLF 129
Cdd:cd14986  10 LFVFTLVGNGLVILVLRRKRKKRSRVNIFILNLAIADLVVafftVLTQIIWEAT----GEWVAGDVLCRIVKYLQVVGLF 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 130 GSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVciLVWLLAFCVSLPdTYYLKTVTSASNNETYCRSFYPEHSIKEWL 209
Cdd:cd14986  86 ASTYILVSMSLDRYQAIVKPMSSLKPRKRARLMIV--VAWVLSFLFSIP-QLVIFVERELGDGVHQCWSSFYTPWQRKVY 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 210 IGMELVSVvlgFAVPFSIIAVFYFLLARAI---------------SASSDQEKHSSR-------------KIIFSYVVVF 261
Cdd:cd14986 163 ITWLATYV---FVIPLIILSYCYGRILRTIwirsrqktdrpiaptAMSCRSVSCVSSrvslisrakiktiKMTLVIILAF 239
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 31083344 262 LVCWLPYHVAVLLDIFSILHYIPftcrlehalFTALHVTQCLSLVHCCVNPVLYSFINRNYRYEL 326
Cdd:cd14986 240 ILCWTPYFIVQLLDVYAGMQQLE---------NDAYVVSETLASLNSALNPLIYGFFSSHLSFEH 295
7tmA_P2Y12-like cd15924
P2Y purinoceptors 12, 13, 14, and similar proteins, member of the class A family of ...
47-326 3.38e-22

P2Y purinoceptors 12, 13, 14, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14). This cluster only includes P2Y12-like receptors as well as closely related orphan receptor, GPR87.


Pssm-ID: 341352 [Multi-domain]  Cd Length: 284  Bit Score: 94.82  E-value: 3.38e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  47 LSFIYIFIFVIGMIANSVVVWVNIQAKTTGyDTHCYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVTHLIFSI 126
Cdd:cd15924   3 FPVLYTVIFFAGILLNGLAMWIFFHIPSKS-SFIIYLKNTVVADLLMILTFPFKILSDAGLGPWQLRTFVCRVTSVLFYF 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 127 NLFGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDTYYLKTVTSASNNETyCRSFYPEHSIK 206
Cdd:cd15924  82 TMYTSIVFLGLISIDRYLKIVRPFKTSFPKSVSFAKILSVVVWALMFLLSLPNMILTNQQPREKNVKK-CSFLKSELGLK 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 207 eWLIGMELVSVVLgFAVPFSIIAVFYFLLARAI-------SASSDQEKHSSRKIIFSYVVVFLVCWLPYHVAVLLDIFSI 279
Cdd:cd15924 161 -WHEIVNYICQVI-FWIVFLLMIVCYTAITKKVyrsyrrvFRSSSSRRKKSNVKIFIIVAVFFVCFVPYHFARIPYTLSQ 238
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 31083344 280 LHYIpFTCRLEHALFTALHVTQCLSLVHCCVNPVLYSFINRNYRYEL 326
Cdd:cd15924 239 TRDV-FDCTAENILFYVKEATLFLSALNVCLDPIIYFFLCKSFRESL 284
7tmA_PAR1 cd15369
protease-activated receptor 1, member of the class A family of seven-transmembrane G ...
50-326 9.45e-22

protease-activated receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320491  Cd Length: 281  Bit Score: 93.68  E-value: 9.45e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  50 IYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVTHLIFSINLF 129
Cdd:cd15369   6 VYTIVFVISLPLNILALVVFLRKMRVKKPAVIYMLNLACADLLFVLLLPFKIAYHFSGNDWLFGEAMCRVVTAAFYCNMY 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 130 GSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDTYYLKTVTSASNNETYCRSFYPEHSIKEWL 209
Cdd:cd15369  86 CSILLMTCISVDRFLAVVYPMQSLSWRTLRRASFTCAAIWLLSIAGVVPLLLSEQTIQIPDLGITTCHDVLNEQLLMGYY 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 210 IGMELVSVVLGFAVPFSIIAVFYFLLARAISASSDQEKHS--SRKIIFSYVV--VFLVCWLPYHVAVLldifsiLHYIPF 285
Cdd:cd15369 166 VYYFSIFSCLFFFVPLIITTVCYVSIIRCLSSSSDVANSSkkTRALFMAVAVfcVFVICFGPTNVLLL------AHYVRF 239
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 31083344 286 TCRLE-HALFTALHVTQCLSLVHCCVNPVLYSFINRNYRYEL 326
Cdd:cd15369 240 AYTSTnDASYFAYLLCVCVGSISCCLDPLIYYYGSSQCQKQL 281
7tmA_HCAR-like cd14991
hydroxycarboxylic acid receptors and related proteins, member of the class A family of ...
50-323 9.56e-22

hydroxycarboxylic acid receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the hydroxycarboxylic acid receptors (HCARs) as well as their closely related receptors, GPR31 and oxoeicosanoid receptor 1 (OXER1). HCARs are members of the class A family of G-protein coupled receptors (GPCRs). HCAR subfamily contain three receptor subtypes: HCAR1, HCAR2, and HCAR3. The endogenous ligand of HCAR1 (also known as lactate receptor 1, GPR104, or GPR81) is L-lactic acid. The endogenous ligands of HCAR2 (also known as niacin receptor 1, GPR109A, nicotinic acid receptor) and HCAR3 (also known as niacin receptor 2, orGPR109B) are 3-hydroxybutyric acid and 3-hydroxyoctanoic acid, respectively. All three HCA receptors are expressed in adipocytes, and are coupled to G(i)-proteins mediating anti-lipolytic effects in fat cells. OXER1 is a receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid, whereas GPR31 is a high-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid (12-S-HETE).


Pssm-ID: 320122 [Multi-domain]  Cd Length: 280  Bit Score: 93.67  E-value: 9.56e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  50 IYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVTHLIFSINLF 129
Cdd:cd14991   6 LLILEFVLGLPGNVVALWIFCFHSRTWKANTVYLFNLVLADFLLLICLPFRIDYYLRGEHWIFGEAWCRVNLFMLSVNRS 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 130 GSIFFLTCMSVDRYLSITY---FTNTPSSRKkmVRRVVCiLVWLLAFCVSLPdtYYLKTVTSASNNETYCRSFYPEHSIK 206
Cdd:cd14991  86 ASIAFLTAVALDRYFKVVHphhRVNRMSVKA--AAGVAG-LLWALVLLLTLP--LLLSTLLTVNSNKSSCHSFSSYTKPS 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 207 EWLIGMELVSvVLGFAVPFSIIAVFYFLLARAISASSDQEKHSSRK----IIFSYVVVFLVCWLPyhvAVLLDIFSILHY 282
Cdd:cd14991 161 LSIRWHNALF-LLEFFLPLGLIVFCSVRIACNLRIRQSLGKQARVQrairLVFLVVIVFVLCFLP---SIIAGLLALVFK 236
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 31083344 283 IPFTCRLEHALFTALHVTQCLSLVHCCVNPVLYSFINRNYR 323
Cdd:cd14991 237 NLGSCRCLNSVAQLFHISLAFTYLNSALDPVIYCFSSPWFR 277
7tmA_ETH-R cd14997
ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G ...
46-278 1.07e-21

ecdysis-triggering hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the ecdysis-triggering hormone receptors found in insects, which are members of the class A family of seven-transmembrane G-protein coupled receptors. Ecdysis-triggering hormones are vital regulatory signals that govern the stereotypic physiological sequence leading to cuticle shedding in insects. Thus, the ETH signaling system has been a target for the design of more sophisticated insect-selective pest control strategies. Two subtypes of ecdysis-triggering hormone receptor were identified in Drosophila melanogaster. Blood-borne ecdysis-triggering hormone (ETH) activates the behavioral sequence through direct actions on the central nervous system. In insects, ecdysis is thought to be controlled by the interaction between peptide hormones; in particular between ecdysis-triggering hormone (ETH) from the periphery and eclosion hormone (EH) and crustacean cardioactive peptide (CCAP) from the central nervous system. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320128 [Multi-domain]  Cd Length: 294  Bit Score: 93.51  E-value: 1.07e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  46 TLSFIYIFIFVIGMIAN---SVVVWVNIQAKTTgydTHCYILNLAIADLWVVLT-IPVWVVSLVQHNQWPMGELTCKVTH 121
Cdd:cd14997   2 LVSVVYGVIFVVGVLGNvlvGIVVWKNKDMRTP---TNIFLVNLSVADLLVLLVcMPVALVETWAREPWLLGEFMCKLVP 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 122 LIFSINLFGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDTYYLKTVTSASNNET---YCRS 198
Cdd:cd14997  79 FVELTVAHASVLTILAISFERYYAICHPLQAKYVCTKRRALVIIALIWLLALLTSSPVLFITEFKEEDFNDGTpvaVCRT 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 199 fypeHSIKEWLIGMELVSVVLGFAVPFSIIAVFYFLLAR---------AISASSDQEK--HSSRKIIF---SYVVVFLVC 264
Cdd:cd14997 159 ----PADTFWKVAYILSTIVVFFVVPLAILSGLYSVICRrlvghpaleSRRADAANRHtlRSRRQVVYmliTVVVLFFVC 234
                       250
                ....*....|....
gi 31083344 265 WLPYHVAVLLDIFS 278
Cdd:cd14997 235 LLPFRVVTLWIIFA 248
7tmA_OXR cd15208
orexin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
51-325 1.96e-21

orexin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Orexins (OXs, also referred to as hypocretins) are neuropeptide hormones that regulate the sleep-wake cycle and potently influence homeostatic systems regulating appetite and feeding behavior or modulating emotional responses such as anxiety or panic. OXs are synthesized as prepro-orexin (PPO) in the hypothalamus and then proteolytically cleaved into two forms of isoforms: orexin-A (OX-A) and orexin-B (OX-B). OXA is a 33 amino-acid peptide with N-terminal pyroglutamyl residue and two intramolecular disulfide bonds, whereas OXB is a 28 amino-acid linear peptide with no disulfide bonds. OX-A binds orexin receptor 1 (OX1R) with high-affinity, but also binds with somewhat low-affinity to OX2R, and signals primarily to Gq coupling, whereas OX-B shows a strong preference for the orexin receptor 2 (OX2R) and signals through Gq or Gi/o coupling. Thus, activation of OX1R or OX2R will activate phospholipase activity and the phosphatidylinositol and calcium signaling pathways. Additionally, OX2R activation can also lead to inhibition of adenylate cyclase.


Pssm-ID: 320336 [Multi-domain]  Cd Length: 303  Bit Score: 93.22  E-value: 1.96e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  51 YIFIFVIGMIANSVV---VWVNIQAKTTgydTHCYILNLAIADLWVVLT-IPVWVVSLVQHNqWPMGELTCKVTHLIFSI 126
Cdd:cd15208   7 YILVFIVGLVGNVLVcfaVWRNHHMRTV---TNYFIVNLSLADFLVIIIcLPATLLVDVTET-WFFGQVLCKIIPYLQTV 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 127 NLFGSIFFLTCMSVDRYLSITYFTNTPSSRKKMvrRVVCILVWLLAFCVSLPDTYYLKTVT--SASNNETYCRSFYPEHS 204
Cdd:cd15208  83 SVSVSVLTLSCIALDRWYAICHPLMFKSTAKRA--RVSILIIWIVSLLIMIPQAIVMECSRvvPLANKTILLTVCDERWS 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 205 IKEWLIGMELVSVVLGFAVPFSIIAVFYFLLARAI-------SASSDQEK----------------HSSR---KIIFSYV 258
Cdd:cd15208 161 DSIYQKVYHICFFLVTYLLPLCLMILAYFQIFRKLwcrqipgTSSVVQRKwnkprksavaaeekqlRSRRktaKMLIVVV 240
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 31083344 259 VVFLVCWLPYHvavlldIFSILHYIPFTCRLEHALFTALH-VTQCLSLVHCCVNPVLYSFINRNYRYE 325
Cdd:cd15208 241 IMFAICYLPVH------LLNILRYVFGLFTVDRETIYAWFlFSHWLVYANSAINPIIYNFMSGKFREE 302
7tmA_GPR171 cd15167
orphan G protein-coupled receptor 171, member of the class A family of seven-transmembrane G ...
48-326 2.31e-21

orphan G protein-coupled receptor 171, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR171 is phylogenetically related to the P2Y family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. A recent study has been reported that the peptide LENSSPQAPARRLLPP (BigLEN) activates GPR17 to regulate body weight in mice; however the biological role of the receptor remains unknown. GPR171 is a member of the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A common feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320295 [Multi-domain]  Cd Length: 282  Bit Score: 92.52  E-value: 2.31e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  48 SFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVTHLIFSIN 127
Cdd:cd15167   4 TYFYYLIFLIGFIGSCFALWAFIQKRSSRKCINIYLINLLTADFLLTLALPVKIAVDLGIAPWKLKIFHCQVTACLIYIN 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 128 LFGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDTyYLKTVTSASNNETYCRSFYPEHSiKE 207
Cdd:cd15167  84 MYLSIIFLGFVSIDRYLQLTHSSKLYRIQEPGFAKMISAVVWTLVLFIMVPNM-AIPIKTIEEKPGVGCADFKTEFG-RH 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 208 WligmELVSVVLGFAVPFS---IIAVFYFLLARAISASSDQEKHSSRKI----IFSYVVVFLVCWLPYHVAVLLDIFSIL 280
Cdd:cd15167 162 W----HVLTNFICMAIFLNfsaIILISNFLVIRKLYRNKDSEEYRNARQalvnILLVTAGYVICFVPYHIVRIPYTLSQS 237
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 31083344 281 HYIPfTCRLEHALFTALHVTQCLSLVHCCVNPVLYSFINRNYRYEL 326
Cdd:cd15167 238 EVIT-DCSLKRSLFLAKESTLLLAVLNLCFDPILYFHLSKAFRSKI 282
7tmA_MCHR2 cd15339
melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane ...
50-326 5.32e-21

melanin concentrating hormone receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320461 [Multi-domain]  Cd Length: 283  Bit Score: 91.41  E-value: 5.32e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  50 IYIFIFVIGMIANSVVVWVNIQ-AKTTGYDThcYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVTHLIFSINL 128
Cdd:cd15339   6 FIGILCSTGLVGNILVLFTIIRsRKKTVPDI--YVCNLAVADLVHIIVMPFLIHQWARGGEWVFGSPLCTIITSLDTCNQ 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 129 FGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDTYYLKTVTSASNNETYCRSFypehSIKEW 208
Cdd:cd15339  84 FACSAIMTAMSLDRYIALVHPFRLTSLRTRSKTIRINLLVWAASFILVLPVWVYAKVIKFRDGLESCAFNL----TSPDD 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 209 LIGMELVSVVLGFAVPFSIIAVFYFLLARAISASSDQEKHSSR--------------KIIFSYVVVFLVCWLPYHVAVLL 274
Cdd:cd15339 160 VLWYTLYQTITTFFFPLPLILICYILILCYTWEMYRKNKKAGRyntsiprqrvmrltKMVLVLVGVFLVSAAPYHVIQLV 239
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 31083344 275 DIFSILHYIPFtcrlehalFTALHVTQCLSLVHCCVNPVLYSFINRNYRYEL 326
Cdd:cd15339 240 NLSVSQPTLAF--------YVSYYLSICLSYASSSINPFLYILLSGNFRKRL 283
7tmA_NPSR cd15197
neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled ...
54-319 8.25e-21

neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR is widely expressed in the brain, and its activation induces an elevation of intracellular calcium and cAMP concentrations, presumably by coupling to G(s) and G(q) proteins. Mutations in NPSR have been associated with an increased susceptibility to asthma. NPSR was originally identified as an orphan receptor GPR154 and is also known as G protein receptor for asthma susceptibility (GPRA) or vasopressin receptor-related receptor 1 (VRR1).


Pssm-ID: 320325 [Multi-domain]  Cd Length: 294  Bit Score: 90.95  E-value: 8.25e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  54 IFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWV----VLTIPVWVVSLvqhnQWPMGELTCKVTHLIFSINLF 129
Cdd:cd15197  10 LFVFIVVGNSSVLFALWMRKAKKSRMNFFITQLAIADLCVglinVLTDIIWRITV----EWRAGDFACKVIRYLQVVVTY 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 130 GSIFFLTCMSVDRYLSITYFTNTPSSRKKmVRRVVCIlVWLLAFCVSLPdTYYLKTVTSASNNETYCRSFYPEHSikEWL 209
Cdd:cd15197  86 ASTYVLVALSIDRYDAICHPMNFSQSGRQ-ARVLICV-AWILSALFSIP-MLIIFEKTGLSNGEVQCWILWPEPW--YWK 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 210 IGMELVSVVLgFAVPFSIIAVFYFLLARAISASSD--------------QEKHSSRKII-----------FSYVVVFLVC 264
Cdd:cd15197 161 VYMTIVAFLV-FFIPATIISICYIIIVRTIWKKSKiqvtinkaglhdgsSRRSSSRGIIprakiktikmtFVIVTVFIIC 239
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 31083344 265 WLPYHVAVLLDIFSILHyipftcRLEHALFTALhVTQCLSLVHCCVNPVLYSFIN 319
Cdd:cd15197 240 WSPYFVFDLLDVFGLLP------RSKTKIAAAT-FIQSLAPLNSAINPLIYCLFS 287
7tmA_P2Y14 cd15149
P2Y purinoceptor 14, member of the class A family of seven-transmembrane G protein-coupled ...
47-326 8.58e-21

P2Y purinoceptor 14, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y14 receptor is activated by UDP-sugars and belongs to the G(i) class of the P2Y family of purinergic G-protein coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-sugars (P2Y14). P2Y14 receptor has been reported to be involved in a diverse set of physiological responses in many epithelia as well as in immune and inflammatory cells.


Pssm-ID: 320277 [Multi-domain]  Cd Length: 284  Bit Score: 91.06  E-value: 8.58e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  47 LSFIYIFIFVIGMIANSVVVWVNIQAKTTGyDTHCYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVTHLIFSI 126
Cdd:cd15149   3 IPVFYSLVFIVGILLNGVNFWIFFYVPSNK-SFIVYLKNIVFADLLMSLTFPFKILSDVELGPWQLNVIVCRYSAVIFYL 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 127 NLFGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDTyYLKTVTSASNNETYCRSFYPEHSIK 206
Cdd:cd15149  82 NMYVGIIFFGLIGFDRYYKIVKPLHTSFVQNVGYSKALSVVVWMLMAVLSVPNI-ILTNQSFHEANYTKCARLKSELGIQ 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 207 eWLIGMELVSVVLgFAVPFSIIAVFYFLLARAISAS-------SDQEKHSSRKIIFSYVVVFLVCWLPYHVAVLLDIFSI 279
Cdd:cd15149 161 -WHKASNYICVSI-FWVVFLLLIIFYVAISRKIYKSnqkfrrnSTNMKAKSSRNIFSILFVFFVCFVPYHALRIPYTLSQ 238
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 31083344 280 LHyIPFTCRLEHALFTALHVTQCLSLVHCCVNPVLYSFINRNYRYEL 326
Cdd:cd15149 239 TG-ADYSCQSKTILYYMKEFTLLLSAANVCLDPIIYFFLCQPFREML 284
7tmA_photoreceptors_insect cd15079
insect photoreceptors R1-R6 and similar proteins, member of the class A family of ...
45-326 2.45e-20

insect photoreceptors R1-R6 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the insect photoreceptors and their closely related proteins. The Drosophila eye is composed of about 800 unit eyes called ommatidia, each of which contains eight photoreceptor cells (R1-R8). The six outer photoreceptors (R1-R6) function like the vertebrate rods and are responsible for motion detection in dim light and image formation. The R1-R6 photoreceptors express a blue-absorbing pigment, Rhodopsin 1(Rh1). The inner photoreceptors (R7 and R8) are considered the equivalent of the color-sensitive vertebrate cone cells, which express a range of different pigments. The R7 photoreceptors express one of two different UV absorbing pigments, either Rh3 or Rh4. Likewise, the R8 photoreceptors express either the blue absorbing pigment Rh5 or green absorbing pigment Rh6. These photoreceptors belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320207 [Multi-domain]  Cd Length: 292  Bit Score: 89.56  E-value: 2.45e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  45 YTLSFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVqHNQWPMGELTCKVTHLIF 124
Cdd:cd15079   1 YLLGFIYIFLGIVSLLGNGLVIYIFSTTKSLRTPSNMLVVNLAISDFLMMIKMPIFIYNSF-YEGWALGPLGCQIYAFLG 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 125 SINLFGSIFFLTCMSVDRYLSITY-FTNTPSSRKKMVRRVVCILVWLLAFCVsLPDTY---------YLKT-----VTSA 189
Cdd:cd15079  80 SLSGIGSIWTNAAIAYDRYNVIVKpLNGNPLTRGKALLLILFIWLYALPWAL-LPLLFgwgryvpegFLTScsfdyLTRD 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 190 SNNETYCRSFYpehsikewligmelvsvVLGFAVPFSIIAVFYFLLARAISA-------------------SSDQEKHSS 250
Cdd:cd15079 159 WNTRSFVATIF-----------------VFAYVIPLIIIIYCYSFIVKAVFAhekalreqakkmnvvslrsNADANKQSA 221
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 251 R----KIIFSYVVVFLVCWLPYHVAVLLDIFSILHYI-PftcrlehaLFTALHVtqCLSLVHCCVNPVLYSFINRNYRYE 325
Cdd:cd15079 222 EiriaKVALTNVFLWFIAWTPYAVVALIGAFGNQSLLtP--------LVSMIPA--LFAKTAACYNPIVYAISHPKYRLE 291

                .
gi 31083344 326 L 326
Cdd:cd15079 292 L 292
7tmA_prokineticin-R cd15204
prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
47-323 1.84e-19

prokineticin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Prokineticins 1 (PROK1) and 2 (PROK2), also known as endocrine gland vascular endothelial factor and Bombina varigata 8, respectively, are multifunctional chemokine-like peptides that are highly conserved across species. Prokineticins can bind with similar affinities to two closely homologous 7-transmembrane G protein coupled receptors, PROKR1 and PROKR2, which are phylogenetically related to the tachykinin receptors. Prokineticins and their GPCRs are widely distributed in human tissues and are involved in numerous physiological roles, including gastrointestinal motility, generation of circadian rhythms, neuron migration and survival, pain sensation, angiogenesis, inflammation, and reproduction. Moreover, different point mutations in genes encoding PROK2 or its receptor (PROKR2) can lead to Kallmann syndrome, a disease characterized by delayed or absent puberty and impaired olfactory function.


Pssm-ID: 320332 [Multi-domain]  Cd Length: 288  Bit Score: 87.33  E-value: 1.84e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  47 LSFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWV-VLTIPVWVVSLVQHNQ-WPMGELTCKVTHLIF 124
Cdd:cd15204   3 LGVVYVLIMLVCGVGNLLLIAVLARYKKLRTLTNLLIANLALSDFLVaVFCLPFEMDYYVVRQRsWTHGDVLCAVVNYLR 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 125 SINLFGSIFFLTCMSVDRYLSITYftntpSSRKKMVRRVVCI---LVWLLAFCVSLPDTYYLKTVTSASNNETYCRSFYP 201
Cdd:cd15204  83 TVSLYVSTNALLVIAIDRYLVIVH-----PLKPRMKRRTACVviaLVWVVSLLLAIPSAVYSKTTPYANQGKIFCGQIWP 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 202 EH---SIKEWLIGMelvsVVLGFAVPFSIIAVFYFLLARAI---------SASSDQEKHSSRK---IIFSYVVVFLVCWL 266
Cdd:cd15204 158 VDqqaYYKAYYLFL----FVLEFVLPVLIMTLCYLRIVRKVwfrrvpgqqTEQIRRRLRRRRRkvrLLVVILTAFVLCWA 233
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 31083344 267 PYHV-AVLLDIFsilhyiPFTCRLEHALFTALHVTQCLSLVHCCVNPVLYSFINRNYR 323
Cdd:cd15204 234 PYYGyAIVRDFF------PTLLSKEKLNTTIFYIVEALAMSNSMINTVVYVAFNNNIR 285
7tmA_GPR87 cd15969
G protein-coupled receptor 87, member of the class A family of seven-transmembrane G ...
50-322 2.43e-19

G protein-coupled receptor 87, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR87 acts as one of multiple receptors for lysophosphatidic acid (LPA). This orphan receptor has been shown to be over-expressed in several malignant tumors including lung squamous cell carcinoma and regulated by p53. GPR87 is phylogenetically closely related to the G(i) class of the P2Y family of purinergic G protein-coupled receptors. P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase.


Pssm-ID: 320635 [Multi-domain]  Cd Length: 283  Bit Score: 86.77  E-value: 2.43e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  50 IYIFIFVIGMIANSVVVWV--NIQAKTTGYdthCYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVTHLIFSIN 127
Cdd:cd15969   6 LYLIIFIGSILLNGLAVWIffHIRNKTSFI---FYLKNIVIADLLMTLTFPFKIIQDSGLGPWNFNFFLCRYTSVLFYAS 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 128 LFGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDTyYLKTVTSASNNETYCRSFYPEHSIKe 207
Cdd:cd15969  83 MYTSIVFLGLISLDRYLKVVKPFGDSRMYSITFTKVLSACVWLIMAFLSLPNI-ILTNGQPTEDNIHDCSKLKSPLGVK- 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 208 WLIGMELVSVVLGFAVpFSIIAVFYFLLARAISASSDQEKHSSRKI------IFSYVVVFLVCWLPYHVAVLLDIFSILH 281
Cdd:cd15969 161 WHTAVSYINICIFVAV-LVILIVCYISISRYIYKSSKQFISSSSRTrkhnqsIRVVVAVFFVCFLPYHLCRIPFTFSQLD 239
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 31083344 282 YIpFTCRLEHALFTALHVTQCLSLVHCCVNPVLYSFINRNY 322
Cdd:cd15969 240 KI-LDCTIKTILYYCKEATLFLSACNVCLDPIIYFFMCRSF 279
7tmA_SKR_NK2R cd16004
substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
51-311 3.72e-19

substance-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The substance-K receptor (SKR), also known as tachykinin receptor 2 (TACR2) or neurokinin A receptor or NK2R, is a G-protein coupled receptor that specifically binds to neurokinin A. The tachykinins are widely distributed throughout the mammalian central and peripheral nervous systems and act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320670 [Multi-domain]  Cd Length: 285  Bit Score: 86.44  E-value: 3.72e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  51 YIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVTHLIFSINLFG 130
Cdd:cd16004   7 YSLIVLVAVTGNATVIWIILAHRRMRTVTNYFIVNLALADLSMAAFNTAFNFVYASHNDWYFGLEFCRFQNFFPITAMFV 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 131 SIFFLTCMSVDRYLSITY-FTNTPSSRKKmvrRVVCILVWLLAFCVSLPDTYYlkTVTSASNNETYCRSFYPEHSIKEWL 209
Cdd:cd16004  87 SIYSMTAIAADRYMAIIHpFKPRLSAGST---KVVIAGIWLVALALAFPQCFY--STVTMDQGRTKCIVAWPGDSGGKHQ 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 210 IGMELVSVVLGFAVPFSIIAVFY-----FLLARAISASSDQEKHSSR--------KIIFSYVVVFLVCWLPYHVAVLLDI 276
Cdd:cd16004 162 LTYHLAVIVLIYLLPLAVMFVTYsiigiTLWRSAVPGHQAHGAYHRQlqakkkfvKTMVVVVVTFAICWLPYHLYFILGS 241
                       250       260       270
                ....*....|....*....|....*....|....*..
gi 31083344 277 FSI-LHYIPFTCRLEHALF-TALHVTQCLSLVHCCVN 311
Cdd:cd16004 242 FNEdIYCQKYIQQVYLAIFwLAMSSTMYNPIIYCCLN 278
7tmA_Opsin_Gq_invertebrates cd15337
invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled ...
50-326 4.29e-19

invertebrate Gq opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The invertebrate Gq-coupled opsin subfamily includes the arthropod and mollusc visual opsins. Like the vertebrate visual opsins, arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. The invertebrate Gq opsins are closely related to the vertebrate melanopsins, the primary photoreceptor molecules for non-visual responses to light, and the R1-R6 photoreceptors, which are the fly equivalent to the vertebrate rods. The Gq opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320459 [Multi-domain]  Cd Length: 292  Bit Score: 86.22  E-value: 4.29e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  50 IYIFIF-VIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTI--PVWVVSLVqHNQWPMGELTCKVTHLIFSI 126
Cdd:cd15337   5 IYIAIVgILGVIGNLLVIYLFSKTKSLRTPSNMFIINLAISDFGFSAVNgfPLKTISSF-NKKWIWGKVACELYGFAGGI 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 127 NLFGSIFFLTCMSVDRYLSITyfTNTPSSRKKMVRR--VVCILVWLLAFCVSLP-----DTYYLKTVtsasnnETYCRSF 199
Cdd:cd15337  84 FGFMSITTLAAISIDRYLVIA--KPLEAMKKMTFKRafIMIIIIWLWSLLWSIPpffgwGRYVPEGF------QTSCTFD 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 200 YPEHSIKEWLIGMELvsVVLGFAVPFSIIAVFYFLLARAISAS-------------SDQEKHSSR--------KIIFSYV 258
Cdd:cd15337 156 YLSRDLNNRLFILGL--FIFGFLCPLLIIIFCYVNIIRAVRNHekemtqtaksgmgKDTEKNDARkkaeiriaKVAIILI 233
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 31083344 259 VVFLVCWLPYHVAVLLDIFSILHYI-PFTCRLEHALFTAlhvtqclSLVHccvNPVLYSFINRNYRYEL 326
Cdd:cd15337 234 SLFLLSWTPYAVVALLGQFGPAYWItPYVSELPVMFAKA-------SAIY---NPIIYALSHPKFRAAL 292
7tmA_GPR34-like cd15920
P2Y-like receptor and similar proteins, member of the class A family of seven-transmembrane G ...
46-323 7.42e-19

P2Y-like receptor and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR34 is phylogenetically related to the P2Y family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. GPR34 is shown to couple to G(i/o) protein and is highly expressed in microglia. Recently, lysophosphatidylserine has been identified as a ligand for GPR34. This group belongs to the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320586 [Multi-domain]  Cd Length: 278  Bit Score: 85.24  E-value: 7.42e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  46 TLSFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVvsLVQHNQWPMgeLTCKVTHLIFS 125
Cdd:cd15920   2 TLPVMYSIICIVGLLSNTLALWVFFLRQQRETSISVYMRNLALADLLLVLCLPFRV--AYQNTAGPL--SFCKIVGAFFY 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 126 INLFGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDTYYLKTVTSASNNetyCRSFypeHSI 205
Cdd:cd15920  78 LNMYASILFLSLISLDRYLKIIKPLQQFKIHTVPWSSAASGGVWLLLLACMIPFLFESRNEGPCDNK---CFHF---RSK 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 206 KEWLIGMELVSVVLGFAvpFSIIAVFYFL-----LARAISASSDQE--KHSSRKIIFSYVV--VFLVCWLPYHVAVLLDI 276
Cdd:cd15920 152 GLTAGGINLTAVVIFYI--LSLLFLYFYAkishkLYKVSLGNAQQQikKASKRAIIKTFIVlaIFIVCFVPYHIVRVPYV 229
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 31083344 277 FSILHYIPfTCRLEHALFTALHVTQCLSLVHCCVNPVLYSFINRNYR 323
Cdd:cd15920 230 LAQIDVIS-SLPWKQTLHIANELVLCLSALNSCLDPIIYFFLSSSFR 275
7tmA_P2Y8 cd15368
purinergic receptor P2Y8, member of the class A family of seven-transmembrane G ...
46-326 1.16e-18

purinergic receptor P2Y8, member of the class A family of seven-transmembrane G protein-coupled receptors; P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320490 [Multi-domain]  Cd Length: 281  Bit Score: 84.82  E-value: 1.16e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  46 TLSFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVTHLIFS 125
Cdd:cd15368   2 ILPVVYSLVALISIPGNLFSLWLLCFHTKPKTPSIIFMINLSLTDLMLACFLPFQIVYHIQRNHWIFGKPLCNVVTVLFY 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 126 INLFGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLP-----DTYYLKTVTSASNNETYCRSFY 200
Cdd:cd15368  82 ANMYSSILTMTCISIERYLGVVYPMRSMRWRKKRYAVAACIGMWLLVLTALSPlertdLTYYVKELNITTCFDVLKWTML 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 201 PehSIKEWLIGMELVSVVLgFAVPFSIIAVFYFLLARAISASSDQ--EKHSSRKIIFSYVV--VFLVCWLPYHVAVLLDI 276
Cdd:cd15368 162 P--NIAAWAAFLFTLFILL-FLIPFIITVYCYVLIILKLVQTSERygREQKRRAIYLALIVllVFITCFAPNNFILLAHM 238
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 31083344 277 FSILHYipftcrlEHALFTALHVTQCLSLVHCCVNPVLYSFINRNYRYEL 326
Cdd:cd15368 239 VSRLFY-------GKSLYHAYKLTLSLSCLNSCLDPFIYYFASKEFRKKL 281
7tmA_GPR34-like cd15148
putative G protein-coupled receptor 34, member of the class A family of seven-transmembrane G ...
47-323 2.02e-18

putative G protein-coupled receptor 34, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the G-protein coupled receptor 34 of unknown function. Orphan GPR34 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320276 [Multi-domain]  Cd Length: 282  Bit Score: 83.97  E-value: 2.02e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  47 LSFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVTHLIFSI 126
Cdd:cd15148   3 LAVFYSLIFLFGLVGNLLALWVFLFIHRKRNSVRIFLINVAIADLLLIICLPFRILYHVNNNQWTLGPLLCKVVGNLFYM 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 127 NLFGSIFFLTCMSVDRYLSItyftNTPSSRKKMVRR----VVCILVWLLAFCVSLPdtyyLKTVTSASNNETYCRSFYPE 202
Cdd:cd15148  83 NMYISIILLGFISLDRYLKI----NRSSRRQKFLTRkwsiVACGVLWAVALVGFVP----MIVLTEKNEESTKCFQYKDR 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 203 HSIKeWLIGMELVSVVLGFAVPFSIIAVFYFLLARAISASSDQEK-------HSSRKIIFSYVVVFLVCWLPYHVAVLLD 275
Cdd:cd15148 155 KNAK-GKAIFNFLIVAMFWLVFLLLILSYGKIAKKLLRISRDKPDfpnaakyNRTARKSFFVLFIFTVCFVPYHAFRIFY 233
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 31083344 276 IFSILHYIPftCRLEHALFTALHVTQCLSLVHCCVNPVLYSFINRNYR 323
Cdd:cd15148 234 ITSQLQNNS--CYWKEILHKTNEIMLLLSAFNSCLDPVMYFLLSSSIR 279
7tmA_Mrgpr cd14973
mas-related G protein-coupled receptors, member of the class A family of seven-transmembrane G ...
46-320 2.28e-18

mas-related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined. Also included in this family is Mas-related G-protein coupled receptor 1-like (MAS1L) which is only found in primates. The angiotensin-II metabolite angiotensin is an endogenous ligand for MAS1L.


Pssm-ID: 320104 [Multi-domain]  Cd Length: 272  Bit Score: 83.84  E-value: 2.28e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  46 TLSFIYIFIFVIGMIANSVVVW-VNIQAKTTGYDThcYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELtCKVTHLIF 124
Cdd:cd14973   2 VIFSLTVLLSLCGLVGNGLVLWlLGFRIKRNPFSV--YILNLAAADFLFLSCQAIQSLEDLLGGSLPGFAL-CRLLATLM 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 125 SINLFGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDTYYLkTVTSASNNETYCRSFypehs 204
Cdd:cd14973  79 FFSYTVGLSLLAAISTERCLSVLFPIWYRCHRPKHLSAVVCALLWALSLLLSVLESYFC-GFLFWKFNESACRTF----- 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 205 ikewligmeLVSVVLGFAVPFSIIAVFYF-LLARAISASsdQEKHSSRK--IIFSYVVVFLVCWLPYHVAVLLDIFSILH 281
Cdd:cd14973 153 ---------NFLSALLFLLLFLVMCVSSLtLLIRVQCSS--QRRPPTRLyvVILLTVLVFLLCGLPLGIYWFLLLWFSNY 221
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 31083344 282 YIPFTcrlehalftaLHVTQCLSLVHCCVNPVLYSFINR 320
Cdd:cd14973 222 LFHTF----------HPISDLLSCVNSSANPIIYFFVGS 250
7tmA_leucokinin-like cd15393
leucokinin-like peptide receptor from tick and related proteins, member of the class A family ...
47-325 2.37e-18

leucokinin-like peptide receptor from tick and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes a leucokinin-like peptide receptor from the Southern cattle tick, Boophilus microplus, a pest of cattle world-wide. Leucokinins are invertebrate neuropeptides that exhibit myotropic and diuretic activity. This receptor is the first neuropeptide receptor known from the Acari and the second known in the subfamily of leucokinin-like peptide G-protein-coupled receptors. The other known leucokinin-like peptide receptor is a lymnokinin receptor from the mollusc Lymnaea stagnalis.


Pssm-ID: 320515 [Multi-domain]  Cd Length: 288  Bit Score: 84.00  E-value: 2.37e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  47 LSFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWV-VLTIPV-WVVSLVQhnQWPMGELTCKVTHLIF 124
Cdd:cd15393   3 LSILYGIISLVAVVGNFLVIWVVAKNRRMRTVTNIFIANLAVADIIIgLFSIPFqFQAALLQ--RWVLPRFMCPFCPFVQ 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 125 SINLFGSIFFLTCMSVDRYLSITYFTNTPSSrKKMVRRVVCIlVWLLAFCVSLPDTYYLKTVTSASNNETYCRSF-YPEH 203
Cdd:cd15393  81 VLSVNVSVFTLTVIAVDRYRAVIHPLKARCS-KKSAKIIILI-IWILALLVALPVALALRVEELTDKTNNGVKPFcLPVG 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 204 SIKEWLIGMELVSVVLGFAVPFSIIAVFYFLLARAISASS----------DQEKHSSRKII---FSYVVVFLVCWLPYHV 270
Cdd:cd15393 159 PSDDWWKIYNLYLVCVQYFVPLVIICYAYTRIAVKIWGTKapgnaqdvrdDEILKNKKKVIkmlIIVVALFALCWLPLQT 238
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 31083344 271 AVLLDIF--SILHY----IPFTCrlehalftalhvTQCLSLVHCCVNPVLYSFINRNYRYE 325
Cdd:cd15393 239 YNLLNEIkpEINKYkyinIIWFC------------SHWLAMSNSCYNPFIYGLYNEKFKRE 287
7tmA_NMBR cd15125
neuromedin B receptor, member of the class A family of seven-transmembrane G protein-coupled ...
50-323 3.08e-18

neuromedin B receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin B receptor (NMBR), also known as BB1, is a G-protein coupled receptor whose endogenous ligand is the neuropeptide neuromedin B. Neuromedin B is a potent mitogen and growth factor for normal and cancerous lung and for gastrointestinal epithelial tissues. NMBR is widely distributed in the CNS, with especially high levels in olfactory nucleus and thalamic regions. The receptor couples primarily to a pertussis-toxin-insensitive G protein of the Gq/11 family, which leads to the activation of phospholipase C. NMBR belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include gastrin-releasing peptide receptor (GRPR) and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin.


Pssm-ID: 320253 [Multi-domain]  Cd Length: 292  Bit Score: 83.85  E-value: 3.08e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  50 IYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVTHLIFSINLF 129
Cdd:cd15125   6 LYLLIITVGLLGNITLVKIFITNSAMRSVPNIFISSLAAGDLLLLVTCVPVDASRYFYEEWMFGTVGCKLIPVIQLTSVG 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 130 GSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDTYYLKTVTSASNNETYCRSFYPEHSIKEWL 209
Cdd:cd15125  86 VSVFTLTALSADRYKAIVNPMDIQTSSAVLRTCLKAIAIWVVSVLLAVPEAVFSEVAHIMPDDNTTFTACIPYPQTDEMH 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 210 IGMELVSVVL-GFAVPFSIIAVFYFLLARAISASS-----DQEKHSSR---------KIIFSYVVVFLVCWLPYHVavlL 274
Cdd:cd15125 166 PKIHSVLIFLvYFLIPLAIISIYYYHIAKTLIKSAhnipgEYSEHSKRqmetrkrlaKIVLVFVGLFAFCWFPNHV---L 242
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 31083344 275 DIFSILHYIPFTCRLEHALFTAlhVTQCLSLVHCCVNPVLYSFINRNYR 323
Cdd:cd15125 243 YMYRSFNYNEIDSSLGHMIVTL--VARVLSFCNSCVNPFALYLLSESFR 289
7tmA_motilin_R cd15132
motilin receptor, member of the class A family of seven-transmembrane G protein-coupled ...
50-323 3.19e-18

motilin receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Motilin receptor, also known as GPR38, is a G-protein coupled receptor that binds the endogenous ligand motilin. Motilin is a 22 amino acid peptide hormone expressed throughout the gastrointestinal tract and stimulates contraction of gut smooth muscle. Motilin is also called as the housekeeper of the gut because it is responsible for the proper filling and emptying of the gastrointestinal tract in response to food intake, and for stimulating the production of pepsin. Motilin receptor shares significant amino acid sequence identity with the growth hormone secretagogue receptor (GHSR) and neurotensin receptors (NTS-R1 and 2).


Pssm-ID: 320260 [Multi-domain]  Cd Length: 289  Bit Score: 83.69  E-value: 3.19e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  50 IYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVTHLIFSINLF 129
Cdd:cd15132   6 VCLILFVVGVTGNTMTVLIIRRYKDMRTTTNLYLSSMAVSDLLILLCLPFDLYRLWKSRPWIFGEFLCRLYHYISEGCTY 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 130 GSIFFLTCMSVDRYLSITYftntPSSRKKMV--RRVVCILVWLLAFC-VSLPDTYYLKTV-----TSASNNETYCRsfYP 201
Cdd:cd15132  86 ATILHITALSIERYLAICF----PLRAKVLVtrRRVKCVIAALWAFAlLSAGPFLFLVGVeqdnnIHPDDFSRECK--HT 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 202 EHSIKEWLIGMELVSVVLGFAVPFSIIAVFYFLLARAI-----------SASSDQEKHSSRKIIFSYVVVFLVCWLPYHV 270
Cdd:cd15132 160 PYAVSSGLLGIMIWVTTTYFFLPMLCLSFLYGFIGRKLwkskndlrgpnAAARERSHRQTVRILAVVVLAFIICWLPFHI 239
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 31083344 271 AVLLDIfsilhyipFTCRLEHALFTALH--VTQCLSLVHCCVNPVLYSFINRNYR 323
Cdd:cd15132 240 GRILFA--------NTEDYRTMMFSQYFniVAMQLFYLSASINPILYNLISRKYR 286
7tmA_NMU-R2 cd15357
neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G ...
47-323 3.77e-18

neuromedin U receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320479 [Multi-domain]  Cd Length: 293  Bit Score: 83.76  E-value: 3.77e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  47 LSFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVL-TIPVWVVSLVQHNQWPMGELTCKVTHLIFS 125
Cdd:cd15357   3 MSLVYAVIFVVGVIGNLLVCLVILKHQNMKTPTNYYLFSLAVSDLLVLLfGMPLEVYEMWSNYPFLFGPVGCYFKTALFE 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 126 INLFGSIFFLTCMSVDRYLSIT--YFTNTPSSRKKMVRrvVCILVWLLAFCVSLPDT-------YYLKTVTSASNNETyC 196
Cdd:cd15357  83 TVCFASILSVTTVSVERYVAILhpFRAKLNSTRERALK--IIVVLWVLSVLFSIPNTsihgiklQYFPNGTLIPDSAT-C 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 197 RSFYPEHsIKEWLIGmelVSVVLGFAVPFSIIAVFYFLLARAISASSDQE------------KHSSRKIIFSYVVVFLVC 264
Cdd:cd15357 160 TVVKPLW-IYNLIIQ---ITSLLFYVLPMGVISVLYYLMGLKLRGDKSLEademnvniqrpsRKSVTKMLFVLVLVFAIC 235
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 265 WLPYHVAVLLDIFSILHYIPFTcrlehALFTALHVTQCLSL-VHCCVNPVLYSFINRNYR 323
Cdd:cd15357 236 WAPFHVDRLFFSFVVEWTEPLA-----NVFNLIHVVSGVFFyLSSAVNPIIYNLLSRRFR 290
7tmA_NMU-R cd15133
neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled ...
47-323 4.47e-18

neuromedin U receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320261 [Multi-domain]  Cd Length: 298  Bit Score: 83.35  E-value: 4.47e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  47 LSFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLT-IPVWVVSLVQHNQWPMGELTCKVTHLIFS 125
Cdd:cd15133   3 VCLTYLLIFVVGVVGNVLTCLVIARHKAMRTPTNYYLFSLAVSDLLVLLLgMPLELYELWQNYPFLLGSGGCYFKTFLFE 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 126 INLFGSIFFLTCMSVDRYLSITY-FTNTPSSRKKMVRRVVCIlVWLLAFCVSLPDT--YYLKTVTSASNNETYCRSFYPE 202
Cdd:cd15133  83 TVCLASILNVTALSVERYIAVVHpLAARTCSTRPRVTRVLGC-VWGVSMLCALPNTslHGIKFLGSGVPASAQCTVRKPQ 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 203 hsikeWLIGMEL-VSVVLGFAVPFSIIAVFYFLLA------RAISASSDQEKHSSR---------------KIIFSYVVV 260
Cdd:cd15133 162 -----AIYNMIPqHTGHLFFVLPMAVISVLYLLMAlrlareRGLDATGAGSKIGTRtgqllqhprtraqvtKMLFILVVV 236
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 31083344 261 FLVCWLPYHVAVLLdifsiLHYIPFTCRLEHALFTALH-VTQCLSLVHCCVNPVLYSFINRNYR 323
Cdd:cd15133 237 FAICWAPFHIDRLM-----WSFISDWTDNLHEVFQYVHiISGVFFYLSSAVNPILYNLMSTRFR 295
7tmA_Melanopsin-like cd15083
vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane ...
45-323 4.99e-18

vertebrate melanopsins and related opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represent the Gq-coupled rhodopsin subfamily consists of melanopsins, insect photoreceptors R1-R6, invertebrate Gq opsins as well as their closely related opsins. Melanopsins (also called Opsin-4) are the primary photoreceptor molecules for non-visual functions such as the photo-entrainment of the circadian rhythm and pupillary constriction in mammals. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. The outer photoreceptors (R1-R6) are the insect Drosophila equivalent to the vertebrate rods and are responsible for image formation and motion detection. The invertebrate G(q) opsins includes the arthropod and mollusk visual opsins as well as invertebrate melanopsins, which are also found in vertebrates. Arthropods possess color vision by the use of multiple opsins sensitive to different light wavelengths. Members of this subfamily belong to the class A of the G protein-coupled receptors and have seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320211 [Multi-domain]  Cd Length: 291  Bit Score: 83.15  E-value: 4.99e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  45 YTLSFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIAD-LWVVLTIPVWVVSLVQHnQWPMGELTCKVTHli 123
Cdd:cd15083   1 YVLGIFILIIGLIGVVGNGLVIYAFCRFKSLRTPANYLIINLAISDfLMCILNCPLMVISSFSG-RWIFGKTGCDMYG-- 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 124 FSINLFG--SIFFLTCMSVDRYLSIT--YFTNTPSSRKKMVRrvVCILVWLLAFCVSLP-----DTYYL-KTVTSASNN- 192
Cdd:cd15083  78 FSGGLFGimSINTLAAIAVDRYLVITrpMKASVRISHRRALI--VIAVVWLYSLLWVLPplfgwSRYVLeGLLTSCSFDy 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 193 ---ETYCRSFYpehsikewligmeLVSVVLGFAVPFSIIAVFYFLLARAISAS----------------SDQEKHSSR-- 251
Cdd:cd15083 156 lsrDDANRSYV-------------ICLLIFGFVLPLLIIIYCYSFIFRAVRRHekamkemakrfskselSSPKARRQAev 222
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 31083344 252 ---KIIFSYVVVFLVCWLPYHVAVLLDIFSILHYIPftcrlehalFTALHVTQCLSLVHCCVNPVLYSFINRNYR 323
Cdd:cd15083 223 ktaKIALLLVLLFCLAWTPYAVVALIGQFGYLEVLT---------PLATAIPAAFAKTSAIYNPVIYAFSHPKFR 288
7tmA_GHSR cd15131
growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G ...
52-323 9.71e-18

growth hormone secretagogue receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Growth hormone secretagogue receptor, GHSR, is also known as GH-releasing peptide receptor (GHRP) or Ghrelin receptor. Ghrelin, the endogenous ligand for GHSR, is an acylated 28-amino acid peptide hormone produced by ghrelin cells in the gastrointestinal tract. Ghrelin, also called hunger hormone, is involved in the regulation of growth hormone release, appetite and feeding, gut motility, lipid and glucose metabolism, and energy balance. It also plays a role in the cardiovascular, immune, and reproductive systems. GHSR couples to G-alpha-11 proteins. Both ghrelin and GHSR are expressed in a wide range of cancer tissues. Recent studies suggested that ghrelin may play a role in processes associated with cancer progression, including cell proliferation, metastasis, apoptosis, and angiogenesis.


Pssm-ID: 320259 [Multi-domain]  Cd Length: 291  Bit Score: 82.24  E-value: 9.71e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  52 IFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVTHLIFSINLFGS 131
Cdd:cd15131   8 VLLFVVGVTGNLMTMLVVSKYRDMRTTTNLYLSSMAFSDLLIFLCMPLDLYRLWQYRPWNFGDLLCKLFQFVSESCTYST 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 132 IFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPdTYYLKTV------TSASNNEtyCRSfyPEHSI 205
Cdd:cd15131  88 ILNITALSVERYFAICFPLRAKVVVTKRRVKLVILVLWAVSFLSAGP-IFVLVGVehengtNPIDTNE--CKA--TEYAV 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 206 KEWLIG-MELVSVVLgFAVPFSIIAVFYFLLARAI-----------SASSDQEKHSSRKIIFSYVVVFLVCWLPYHVAVL 273
Cdd:cd15131 163 RSGLLTiMVWVSSVF-FFLPVFCLTVLYSLIGRKLwrrrrenigpnASHRDKNNRQTVKMLAVVVFAFVLCWLPFHVGRY 241
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 31083344 274 LDIFSILhyipfTCRLEHALFTAL--HVTQCLSLVHCCVNPVLYSFINRNYR 323
Cdd:cd15131 242 LFSKSFE-----AGSLEIALISQYcnLVSFVLFYLSAAINPILYNIMSKKYR 288
7tmA_NMU-R1 cd15358
neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G ...
50-323 1.09e-17

neuromedin U receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuromedin U (NMU) is a highly conserved neuropeptide with a common C-terminal heptapeptide sequence (FLFRPRN-amide) found at the highest levels in the gastrointestinal tract and pituitary gland of mammals. Disruption or replacement of residues in the conserved heptapeptide region can result in the reduced ability of NMU to stimulate smooth-muscle contraction. Two G-protein coupled receptor subtypes, NMU-R1 and NMU-R2, with a distinct expression pattern, have been identified to bind NMU. NMU-R1 is expressed primarily in the peripheral nervous system, while NMU-R2 is mainly found in the central nervous system. Neuromedin S, a 36 amino-acid neuropeptide that shares a conserved C-terminal heptapeptide sequence with NMU, is a highly potent and selective NMU-R2 agonist. Pharmacological studies have shown that both NMU and NMS inhibit food intake and reduce body weight, and that NMU increases energy expenditure.


Pssm-ID: 320480 [Multi-domain]  Cd Length: 305  Bit Score: 82.51  E-value: 1.09e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  50 IYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWV-VLTIPVWVVSLVQHNQWPMGELTCKVTHLIFSINL 128
Cdd:cd15358   6 TYLLIFVVGAVGNGLTCIVILRHKVMRTPTNYYLFSLAVSDLLVlLLGMPLELYEMWSNYPFLLGAGGCYFKTLLFETVC 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 129 FGSIFFLTCMSVDRYLSITYftntPSSRKKMVRRV----VCILVWLLAFCVSLPDTyylkTVTSASNNETYCRSFYPEHS 204
Cdd:cd15358  86 FASILNVTALSVERYIAVVH----PLKAKYVVTRThakrVIGAVWVVSILCSIPNT----SLHGIFQLTVPCRGPVPDSA 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 205 I-----KEWLIGMEL-VSVVLGFAVPFSIIAVFYFL-------------LARAISASSDQEKHSSR-----------KII 254
Cdd:cd15358 158 TcmlvkPRWMYNLIIqITTLLFFFLPMGTISVLYLLiglqlkrekmllvLEAKGSKAGDSYQHRRIqqekrrrrqvtKML 237
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 255 FSYVVVFLVCWLPYHVAVLLDIFSILHYIPFtcrleHALFTALHV-TQCLSLVHCCVNPVLYSFINRNYR 323
Cdd:cd15358 238 FVLVVVFGICWAPFHTDRLMWSFISQWTGEL-----HLAFQYVHIiSGVFFYLSSAANPVLYNLMSTRFR 302
7tmA_BRS-3 cd15123
bombesin receptor subtype 3, member of the class A family of seven-transmembrane G ...
46-323 1.65e-17

bombesin receptor subtype 3, member of the class A family of seven-transmembrane G protein-coupled receptors; BRS-3 is classified as an orphan receptor and belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and gastrin-releasing peptide receptor (GRPR). Bombesin is a tetradecapeptide, originally isolated from frog skin. Mammalian bombesin-related peptides are widely distributed in the gastrointestinal and central nervous systems. The bombesin family receptors couple primarily to the G proteins of G(q/11) family. BRS-3 interacts with known naturally-occurring bombesin-related peptides with low affinity; however, no endogenous high-affinity ligand to the receptor has been identified. BRS-3 is suggested to play a role in sperm cell division and maturation.


Pssm-ID: 320251 [Multi-domain]  Cd Length: 294  Bit Score: 81.89  E-value: 1.65e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  46 TLSFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLT-IPVWVVSLVQhNQWPMGELTCKVTHLIF 124
Cdd:cd15123   2 AIYVTYAVIISVGILGNAILIKVFFKIKSMQTVPNIFITSLAFGDLLLLLTcVPVDATRYIA-DTWLFGRIGCKLLSFIQ 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 125 SINLFGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDTYY--LKTVTSASNNETY--CRSFY 200
Cdd:cd15123  81 LTSVGVSVFTLTVLSADRYRAIVKPLELQTSDAVLKTCCKAGCVWIVSMLFAIPEAVFsdLYSFRDPEKNTTFeaCAPYP 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 201 PEHSIKEWLigMELVSVVLGFAVPFSIIAVFYFLLARAISAS-----SDQEKHSSRKI---------IFSYVVVFLVCWL 266
Cdd:cd15123 161 VSEKILQEI--HSLLCFLVFYIIPLSIISVYYFLIARTLYKStfnmpAEEHSHARKQIesrkrvaktVLVLVALFAFCWL 238
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 31083344 267 PYHVAVLLDIFSILHYIpfTCRLEHALFTALhvTQCLSLVHCCVNPVLYSFINRNYR 323
Cdd:cd15123 239 PNHILYLYRSFTYHTSV--DSSAFHLIATIF--SRVLAFSNSCVNPFALYWLSKSFR 291
7tmA_P2Y12 cd15150
P2Y purinoceptor 12, member of the class A family of seven-transmembrane G protein-coupled ...
48-327 2.17e-17

P2Y purinoceptor 12, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y12 receptor (P2Y12R) is found predominantly on the surface of blood platelets and is activated by adenosine diphosphate (ADP). P2Y12R plays an important role in the regulation of blood clotting and belongs to the G(i) class of the P2Y family of purinergic G protein-coupled receptors. P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-sugars (P2Y14).


Pssm-ID: 341326  Cd Length: 285  Bit Score: 81.40  E-value: 2.17e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  48 SFIYIFIFVIGMIANSVVVWVNIQAKTTGYDThCYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVTHLIFSIN 127
Cdd:cd15150   4 PLLYTVLFIVGLTMNGLAMRVFFQIPSKSNFI-IFLKNTVISDLLMILTFPFKILSDAKLGSWPLRGFVCQVTSVIFYFT 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 128 LFGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDTyYLKTVTSASNNETYCRSFYPEHSike 207
Cdd:cd15150  83 MYISILFLGLITIDRYQKTTRPFKTSNPKNLLGAKILSTVIWASMFALSLPNM-ILTNRQPTPKNVKKCSLLKSEFG--- 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 208 wLIGMELVSVV--LGFAVPFSIIAVFYFLLARAISAS---SDQEKHSSRKII----FSYVVVFLVCWLPYHVAVLLDIFS 278
Cdd:cd15150 159 -LVWHEIVNYIcqVIFWVNFLIVIVCYTLITKELYKSykrTRGVGKVSRKKVnvkvFIIIAVFFICFVPFHFARIPYTLS 237
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 31083344 279 ILHYIpFTCRLEHALFTALHVTQCLSLVHCCVNPVLYSFINRNYRYELM 327
Cdd:cd15150 238 QTRDV-FDCTAKNTLFYVKESTLWLTSLNACLDPFIYFFLCKSFRNSLI 285
7tmA_ET_R-like cd14977
endothelin receptors and related proteins, member of the class A family of seven-transmembrane ...
45-323 2.88e-17

endothelin receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes endothelin receptors, bombesin receptor subtype 3 (BRS-3), gastrin-releasing peptide receptor (GRPR), neuromedin B receptor (NMB-R), endothelin B receptor-like 2 (ETBR-LP-2), and GRP37. The endothelin receptors and related proteins are members of the seven transmembrane rhodopsin-like G-protein coupled receptor family (class A GPCRs) which activate multiple effectors via different types of G protein.


Pssm-ID: 320108 [Multi-domain]  Cd Length: 292  Bit Score: 80.93  E-value: 2.88e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  45 YTLSFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLT-IPVWVVSLVQhNQWPMGELTCKVTHLI 123
Cdd:cd14977   1 YVIMSLSLVIFAVGIIGNLMVLCIVCTNYYMRSVPNILIASLALGDLLLLLLcVPLNAYNLLT-KDWLFGDVMCKLVPFI 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 124 FSINLFGSIFFLTCMSVDRYLSITyftntPSSRKKMVRR-----VVCILVWLLAFCVSLPDTYYLKTVT---SASNNETY 195
Cdd:cd14977  80 QVTSLGVTVFSLCALSIDRYRAAV-----NSMPMQTIGAclstcVKLAVIWVGSVLLAVPEAVLSTVARessLDNSSLTV 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 196 CrSFYPEHS-------IKEWLIgmelvsVVLGFAVPFSIIAVFYFLLARAISAS--------SDQEKHSSR--KIIFSYV 258
Cdd:cd14977 155 C-IMKPSTPfaetypkARSWWL------FGCYFCLPLAFTAVCYLLMARTLIRAakeytrgtKKHMKQRRQlaKTVLCLV 227
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 31083344 259 VVFLVCWLPYHVavlLDIFSILHYIPFTCRLEHALFTALHVTQCLSLVHCCVNPVLYSFINRNYR 323
Cdd:cd14977 228 LVFAFCWLPEHI---SNILRATLYNEVLIDTRSTLDILDLIGQFLSFFNSCVNPIALYLLSEPFR 289
7tmA_Trissin_R cd15012
trissin receptor and related proteins, member of the class A family of seven-transmembrane G ...
50-323 3.23e-17

trissin receptor and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the Drosophila melanogaster trissin receptor and closely related invertebrate proteins which are a member of the class A family of seven-transmembrane G-protein coupled receptors. The cysteine-rich trissin has been shown to be an endogenous ligand for the orphan CG34381 in Drosophila melanogaster. Trissin is a peptide composed of 28 amino acids with three intrachain disulfide bonds with no significant structural similarities to known endogenous peptides. Cysteine-rich peptides are known to have antimicrobial or toxicant activities, although frequently their mechanism of action is poorly understood. Since the expression of trissin and its receptor is reported to predominantly localize to the brain and thoracicoabdominal ganglion, trissin is predicted to behave as a neuropeptide. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320140 [Multi-domain]  Cd Length: 277  Bit Score: 80.57  E-value: 3.23e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  50 IYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVL--TIPVWVVSLVQHnqWPMGELTCKVTHLIFSIN 127
Cdd:cd15012   5 LYTLVFCCCFFGNLLVILVVTSHRRMRTITNFFLANLAVADLCVGIfcVLQNLSIYLIPS--WPFGEVLCRMYQFVHSLS 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 128 LFGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDTYYLKTVTSASNNETYCRSFYPEHSIKE 207
Cdd:cd15012  83 YTASIGILVVISVERYIAILHPLRCKQLLTAARLRVTIVTVWLTSAVYNTPYFVFSQTVEILVTQDGQEEEICVLDREMF 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 208 WLIGMELVSVVLGFAVPFSIIAVFYFLLARAISASSDQEKHssRKII---FSYVVVFLVCWLPYHVAVLLDIFSiLHYIP 284
Cdd:cd15012 163 NSKLYDTINFIVWYLIPLLIMTVLYSKISIVLWKSSSIEAR--RKVVrllVAVVVSFALCNLPYHARKMWQYWS-EPYRC 239
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 31083344 285 FTCRleHALFTALhvTQCLSLVHCCVNPVLYSFINRNYR 323
Cdd:cd15012 240 DSNW--NALLTPL--TFLVLYFNSAVNPLLYAFLSKRFR 274
7tmA_GPR20 cd15163
G protein-coupled receptor 20, member of the class A family of seven-transmembrane G ...
47-323 3.74e-17

G protein-coupled receptor 20, member of the class A family of seven-transmembrane G protein-coupled receptors; Orphan GPR20 is phylogenetically related to the P2Y family of purinergic G protein-coupled receptors. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. GPR20 has been shown to constitutively activate G(i) proteins in the absence of a ligand; however its functional role is not known. GPR20 is a member of the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A common feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320291 [Multi-domain]  Cd Length: 258  Bit Score: 80.22  E-value: 3.74e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  47 LSFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVQHNqwpmGELTCKVTHLI-FS 125
Cdd:cd15163   3 LMVINTLIFLVGIVLNSLALYVFCFRTKTKTTSVIYTINLVVTDLLVGLSLPTRIVMYYSAG----NCLTCSFVHIFsYF 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 126 INLFGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVslpdTYYLKTVTSASNNETYCRSFypehsi 205
Cdd:cd15163  79 VNMYCSILFLTCICVDRYLAIVQVEASRRWRNPNYAKGICVFIWLFAIVV----TFSILTTAIKFASCCLSKLF------ 148
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 206 kewligmelVSVVLGFAVPFSIIAVFYFLLARAISASSDQEKHSSRK-----IIFSYVVVFLVCWLPYHVAVLldIFSIL 280
Cdd:cd15163 149 ---------ALTVFEFFLPLLIITFFTIRIMCALSRPGLMHQSRERRmravqLLITVLIIFMICFTPFHVRQV--AVAFN 217
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 31083344 281 HYIPFtcrleHALFTALHVTQCLSLVHCCVNPVLYSFINRNYR 323
Cdd:cd15163 218 PDIPH-----HTSLIVYHVTVTLSSLNSCMDPIVYCFVTNNFQ 255
7tmA_CCK_R cd15206
cholecystokinin receptors, member of the class A family of seven-transmembrane G ...
51-323 4.24e-17

cholecystokinin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320334 [Multi-domain]  Cd Length: 269  Bit Score: 80.13  E-value: 4.24e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  51 YIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWV-VLTIPVWVVSLVQHNqWPMGELTCKVTHLIFSINLF 129
Cdd:cd15206   7 YSVIFLLAVVGNILVIVTLVQNKRMRTVTNVFLLNLAVSDLLLaVFCMPFTLVGQLLRN-FIFGEVMCKLIPYFQAVSVS 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 130 GSIFFLTCMSVDRYLSITyftNTPSSRKKMVR----RVVCIlVWLLAFCVSLPDTYYLKTVTSASNNETYCRSFYPEHSI 205
Cdd:cd15206  86 VSTFTLVAISLERYFAIC---HPLKSRVWQTLshayKVIAG-IWLLSFLIMSPILVFSNLIPMSRPGGHKCREVWPNEIA 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 206 KEwliGMELVSVVLGFAVPFSIIAVFYFLLARAISASsdqeKHSSRKIIFSYVVVFLVCWLPYHVAVLLDIFSILHYipf 285
Cdd:cd15206 162 EQ---AWYVFLDLMLLVIPGLVMSVAYGLISWTLLEA----KKRVIRMLFVIVVEFFICWTPLYVINTWKAFDPPSA--- 231
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 31083344 286 tcrLEHALFTALHVTQCLSLVHCCVNPVLYSFINRNYR 323
Cdd:cd15206 232 ---ARYVSSTTISLIQLLAYISSCVNPITYCFMNKRFR 266
7tmA_NKR_NK3R cd16003
neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled ...
48-311 7.16e-17

neuromedin-K receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neuromedin-K receptor (NKR), also known as tachykinin receptor 3 (TACR3) or neurokinin B receptor or NK3R, is a G-protein coupled receptor that specifically binds to neurokinin B. The tachykinins (TKs) act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. NK3R is activated by its high-affinity ligand, NKB, which is primarily involved in the central nervous system and plays a critical role in the regulation of gonadotropin hormone release and the onset of puberty.


Pssm-ID: 320669 [Multi-domain]  Cd Length: 282  Bit Score: 79.59  E-value: 7.16e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  48 SFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVTHLIFSIN 127
Cdd:cd16003   4 SLAYGFVVAVAVFGNLIVIWIILAHKRMRTVTNYFLVNLAFSDASMAAFNTLINFIYALHSEWYFGEAYCRFHNFFPITS 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 128 LFGSIFFLTCMSVDRYLSITYFTNTPSSRKkmVRRVVCILVWLLAFCVSLPDTYYLKTVTSASnnETYCRSFYPEHSIKE 207
Cdd:cd16003  84 VFASIYSMTAIAVDRYMAIIDPLKPRLSAT--ATKVVIGSIWILAFLLAFPQCLYSKTKVMPG--RTLCFVAWPGGPDQH 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 208 WLigMELVSVVLGFAVPFSIIAVFYFLLARAI------SASSD------QEKHSSRKIIFSYVVVFLVCWLPYHVAVLLD 275
Cdd:cd16003 160 FT--YHIIVIVLVYCLPLLVMGITYTIVGITLwggeipGDTSDkyheqlRAKRKVVKMMIIVVLTFAICWLPYHIYFIVT 237
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 31083344 276 -IFSILHYIPFTCRLEHALF-TALHVTQCLSLVHCCVN 311
Cdd:cd16003 238 gLYQQLNRWKYIQQVYLASFwLAMSSTMYNPIIYCCLN 275
7tmA_ET-AR cd15975
endothelin A (or endothelin-1) receptor, member of the class A family of seven-transmembrane G ...
45-323 1.16e-16

endothelin A (or endothelin-1) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320641 [Multi-domain]  Cd Length: 300  Bit Score: 79.52  E-value: 1.16e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  45 YTLSFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADL-WVVLTIPVWVVSLVQhNQWPM-----GELTCK 118
Cdd:cd15975   1 YINTVLSCIIFIVGMVGNATLLRIIYQNKCMRNGPNALIASLALGDLiYIVIDIPINVYKLLA-QKWPFddssfGVFLCK 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 119 VTHLIFSINLFGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDTYYLKTVTSASNNETYCRS 198
Cdd:cd15975  80 LVPFLQKASVGITVLNLCALSVDRYRAVASWSRVQGIGIPLITAIEIFSIWVLSFILAIPEAIGFVMVPFEYNGEQYRTC 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 199 -FYPEHSIKE--------WLIGmelvsvvLGFAVPFSIIAVFYFLLA-----------RAISASSDQEKHSSRKIIFSYV 258
Cdd:cd15975 160 mLNATTKFMNfyvdakdwWLFG-------FYFCVPLACTAIFYTLMTcemlnrrkgslRIALSEHLKQRREVAKTVFCLV 232
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 31083344 259 VVFLVCWLPYHVAVLLDIFSILHYIPFTCRLEHALFTALHVTQCLSLVHCCVNPVLYSFINRNYR 323
Cdd:cd15975 233 VIFALCWFPLHLSRILKKTVYNENDPRRCELLSFLLVMDYISINLATMNSCINPIALYFVSKKFK 297
7tmA_P2Y13 cd15151
P2Y purinoceptor 13, member of the class A family of seven-transmembrane G protein-coupled ...
50-326 1.16e-16

P2Y purinoceptor 13, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y13 receptor (P2Y13R) is activated by adenosine diphosphate (ADP) and belongs to the G(i) class of the P2Y family of purinergic G protein-coupled receptors. P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-sugars. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5 and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12 and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-sugars (P2Y14).


Pssm-ID: 341327  Cd Length: 284  Bit Score: 79.05  E-value: 1.16e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  50 IYIFIFVIGMIANSVVVWVNIQAKTTGYDThCYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVTHLIFSINLF 129
Cdd:cd15151   6 LYTVLFLVGLILNSVAAWIFFHIPSTSTFI-VYLKNTLVADLIMTLMLPFKILSDSGLGPWQLRAFVCRFSAVVFYITMY 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 130 GSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDTYYLKTVTSASNNETyCRSFYPEHSIKeWL 209
Cdd:cd15151  85 ISIILLGLISFDRYLKIVRPFGKSWVQRVRFAKILSGAVWLVMFLLSVPNMILSNKPATPISVKK-CASLKSPLGLK-WH 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 210 IGMELVSVVLGFAVpFSIIAVFYFLLARAI------SASSDQEKHSSRKI-IFSYVVVFLVCWLPYHVAVLLDIFSILHY 282
Cdd:cd15151 163 EVVNYICQFIFWGV-FALMVLFYTIISKKVyesykkSRSKDNKASKKTKAkVFIIVAVFFVCFAPFHFVRVPYTLSQTGK 241
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 31083344 283 IPfTCRLEHALFTALHVTQCLSLVHCCVNPVLYSFINRNYRYEL 326
Cdd:cd15151 242 IT-DCQLQNLLYIAKEITLWLAATNVCLDPLIYIFLCKSFRQRL 284
7tmA_GRPR cd15124
gastrin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
45-323 1.38e-16

gastrin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The gastrin-releasing peptide receptor (GRPR) is a G-protein coupled receptor whose endogenous ligand is gastrin releasing peptide. GRP shares high sequence homology with the neuropeptide neuromedin B in the C-terminal region. This receptor is high glycosylated and couples to a pertussis-toxin-insensitive G protein of the family of Gq/11, which leads to the activation of phospholipase C. Gastrin-releasing peptide (GRP) is a potent mitogen for neoplastic tissues and involved in regulating multiple functions of the gastrointestinal and central nervous systems. These include the release of gastrointestinal hormones, the contraction of smooth muscle cells, and the proliferation of epithelial cells. GRPR belongs to the bombesin subfamily of G-protein coupled receptors, whose members also include neuromedin B receptor (NMBR) and bombesin receptor subtype 3 (BRS-3). Bombesin is a tetradecapeptide, originally isolated from frog skin.


Pssm-ID: 320252 [Multi-domain]  Cd Length: 293  Bit Score: 79.17  E-value: 1.38e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  45 YTLSFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVTHLIF 124
Cdd:cd15124   1 YAIPTVYGIIILIGLIGNITLIKIFCTVKSMRNVPNLFISSLALGDLLLLVTCAPVDASRYLADEWLFGRVGCKLIPFIQ 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 125 SINLFGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDTYY--LKTVTSASNNETYCRSFYPE 202
Cdd:cd15124  81 LTSVGVSVFTLTALSADRYKAIVRPMDIQASNALMKICLKAALIWILSMLLAIPEAVFsdLHPFYDKSTNKTFVSCAPYP 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 203 HSIKEWLIGMELVSVVLGFAVPFSIIAVFYFLLARAISASS-----DQEKHSSRKI---------IFSYVVVFLVCWLPY 268
Cdd:cd15124 161 HSNELHPKIHSMASFLIFYVIPLSIISVYYYFIAKNLIRSAynlpvEGNVHVRRQIesrkrlaktVLVFVGLFAFCWLPN 240
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 31083344 269 HVAVLldiFSILHYIPFTCRLEHalFTALHVTQCLSLVHCCVNPVLYSFINRNYR 323
Cdd:cd15124 241 HIIYL---YRSYHYSEVDTSMLH--FVSSICARILAFTNSCVNPFALYLLSKSFR 290
7tmA_GPR151 cd15002
G protein-coupled receptor 151, member of the class A family of seven-transmembrane G ...
50-326 1.46e-16

G protein-coupled receptor 151, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 151 (GRP151) is an orphan receptor of unknown function. Its expression is conserved in habenular axonal projections of vertebrates and may be a promising novel target for psychiatric drug development. GPR151 shows high sequence similarity with galanin receptors (GALR). GPR151 is a member of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320133 [Multi-domain]  Cd Length: 280  Bit Score: 78.99  E-value: 1.46e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  50 IYIFIFVIGMIANSVVVWV--NIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVTHLIFSIN 127
Cdd:cd15002   5 LLGVICLLGFAGNLMVIGIllNNARKGKPSLIDSLILNLSAADLLLLLFSVPFRAAAYSKGSWPLGWFVCKTADWFGHAC 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 128 LFGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVcILVWLLAFCVSLPDtYYLKTVTSaSNNETYCRSFYPEHSiKE 207
Cdd:cd15002  85 MAAKSFTIAVLAKACYMYVVNPTKQVTIKQRRITAVV-ASIWVPACLLPLPQ-WLFRTVKQ-SEGVYLCILCIPPLA-HE 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 208 WLIGMELVSVVLGFAVPFSIIAVFY-----FLLARAISASSDQEKHSSRKI---IFSYVVVFLVCWLPYHVAVLLdIFSI 279
Cdd:cd15002 161 FMSAFVKLYPLFVFCLPLTFALFYFwraygQCQRRGTKTQNLRNQIRSRKLthmLLSVVLAFTILWLPEWVAWLW-LIHI 239
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 31083344 280 LHYIPFTcrleHALFTALhvTQCLSLVHCCVNPVLYSFINRNYRYEL 326
Cdd:cd15002 240 KSSGSSP----PQLFNVL--AQLLAFSISSVNPIIFLLMSEEFREGF 280
7tmA_5-HT2 cd15052
serotonin receptor subtype 2, member of the class A family of seven-transmembrane G ...
49-323 2.76e-16

serotonin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320180 [Multi-domain]  Cd Length: 262  Bit Score: 77.74  E-value: 2.76e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  49 FIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWV-VLTIPVWVVSLVQHNQWPMGELTCKVthLIFSIN 127
Cdd:cd15052   5 LLLLLLVIATIGGNILVCLAISLEKRLQNVTNYFLMSLAIADLLVgLLVMPLSILTELFGGVWPLPLVLCLL--WVTLDV 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 128 LF--GSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDT-YYLKTVTSASNNETyCRSFYPEHS 204
Cdd:cd15052  83 LFctASIMHLCTISLDRYMAIRYPLRTRRNKSRTTVFLKIAIVWLISIGISSPIPvLGIIDTTNVLNNGT-CVLFNPNFV 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 205 IkewligmelVSVVLGFAVPFSIIAVFYFLLARAISAssdqeKHSSRKIIFSYVVVFLVCWLPYHVAVLLDIFSilhyIP 284
Cdd:cd15052 162 I---------YGSIVAFFIPLLIMVVTYALTIRLLSN-----EQKASKVLGIVFAVFVICWCPFFITNILTGLC----EE 223
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 31083344 285 FTCRLEHALFTALhvtQCLSLVHCCVNPVLYSFINRNYR 323
Cdd:cd15052 224 CNCRISPWLLSVF---VWLGYVSSTINPIIYTIFNKTFR 259
7tmA_AKHR cd15382
adipokinetic hormone receptor, member of the class A family of seven-transmembrane G ...
49-326 4.46e-16

adipokinetic hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Adipokinetic hormone (AKH) is a lipid-mobilizing hormone that is involved in control of insect metabolism. Generally, AKH behaves as a typical stress hormone by mobilizing lipids, carbohydrates and/or certain amino acids such as proline. Thus, it utilizes the body's energy reserves to fight the immediate stress problems and subdue processes that are less important. Although AKH is known to responsible for regulating the energy metabolism during insect flight, it is also found in insects that have lost its functional wings and predominantly walk for their locomotion. AKH is structurally related to the mammalian gonadotropin-releasing hormone (GnRH) and they share a common ancestor. Both GnRH and AKH receptors are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320504 [Multi-domain]  Cd Length: 298  Bit Score: 77.74  E-value: 4.46e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  49 FIYIFIFVIGMIANSVVVWVNIQAK-TTGYDTHCYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVTHLIFSIN 127
Cdd:cd15382   5 IVYSVLFLIAAVGNLTVLLILLRNRrRKRSRVNILLMHLAIADLLVTFIMMPLEIGWAATVAWLAGDFLCRLMLFFRAFG 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 128 LFGSIFFLTCMSVDRYLSITYFTNTPSSRKKmvRRVVCILVWLLAFCVSLPDTYYLKtVTSASNNETY--CRSF--YPEH 203
Cdd:cd15382  85 LYLSSFVLVCISLDRYFAILKPLRLSDARRR--GRIMLAVAWVISFLCSIPQSFIFH-VESHPCVTWFsqCVTFnfFPSH 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 204 SIKewlIGMELVSVVLGFAVPFSIIAVFYFLLARAISASSDQEKHSSR------------------------KIIFSYVV 259
Cdd:cd15382 162 DHE---LAYNIFNMITMYALPLIIIVFCYSLILCEISRKSKEKKEDVSeksssvrlrrssvgllerarsrtlKMTIVIVL 238
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 31083344 260 VFLVCWLPYHVAVLLDIFSILHYIPFTCRLEHALFTalhvtqcLSLVHCCVNPVLYSFINRNYRYEL 326
Cdd:cd15382 239 VFIICWTPYFIMSLWYWFDRESASKVDPRIQKGLFL-------FAVSNSCMNPIVYGYFSIDLRREL 298
7tmA_D2-like_dopamine_R cd15053
D2-like dopamine receptors, member of the class A family of seven-transmembrane G ...
79-330 6.16e-16

D2-like dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320181 [Multi-domain]  Cd Length: 263  Bit Score: 76.62  E-value: 6.16e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  79 THCYILNLAIADLWV-VLTIPVWVVSLVQHNQWPMGELTCKVTHLIFSINLFGSIFFLTCMSVDRYLSITYftNTPSSRK 157
Cdd:cd15053  35 TNYFIVSLAVADLLVaILVMPFAVYVEVNGGKWYLGPILCDIYIAMDVMCSTASIFNLCAISIDRYIAVTQ--PIKYARQ 112
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 158 KMVRRVVCI--LVWLLAFCVSLPDTYYLKTVtsASNNETYCRSFYPEHSIkewligmelVSVVLGFAVPFSIIAVFYFLL 235
Cdd:cd15053 113 KNSKRVLLTiaIVWVVSAAIACPLLFGLNNV--PYRDPEECRFYNPDFII---------YSSISSFYIPCIVMLLLYYRI 181
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 236 ARAIsassdQEKHSSRKIIFSYVVVFLVCWLPYHVAVLLDIFSILhYIPFTCRLEHALFTAlhvTQCLSLVHCCVNPVLY 315
Cdd:cd15053 182 FRAL-----RREKKATKTLAIVLGVFLFCWLPFFTLNILNAICPK-LQNQSCHVGPALFSL---TTWLGYVNSFLNPIIY 252
                       250
                ....*....|....*
gi 31083344 316 SFINRNYRyelmKAF 330
Cdd:cd15053 253 TIFNIEFR----KAF 263
7tmA_ET-CR cd15977
endothelin C receptor, member of the class A family of seven-transmembrane G protein-coupled ...
45-323 6.21e-16

endothelin C receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain. The ET-C receptor is specific for endothelin-3 on frog dermal melanophores; its activation causes dispersion of pigment granules.


Pssm-ID: 320643 [Multi-domain]  Cd Length: 296  Bit Score: 77.25  E-value: 6.21e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  45 YTLSFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADL-WVVLTIPVWVVSLVQHNqWPMGELTCKVTHLI 123
Cdd:cd15977   1 YVNTILSCVIFLVGIIGNSTLLRIIYKNKCMRNGPNVLIASLALGDLlYILIAIPINVIKLIAED-WPFGVHVCKLYPFI 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 124 FSINLFGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDTYYLKTVTSASNNETYCRSFYPEH 203
Cdd:cd15977  80 QKASVGITVLSLCALSIDRYRAVASWSRIRGIGIPVWKAVEVTLIWAVAIIVAVPEAIAFDMVEIDYRGQTLLVCMLPME 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 204 SIKEWLIGMELVSV--VLG--FAVPFSIIAVFYFLLA----------RAISASSDQEKHSSRKIIFSYVVVFLVCWLPYH 269
Cdd:cd15977 160 QTSSFMRFYQDVKDwwLFGfyFCLPLACTGVFYTLMScemlsikngmRIALNDHMKQRREVAKTVFCLVVIFALCWLPLH 239
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 31083344 270 VAVLLDIFSILHYIPFTCRLEHALFTALHVTQCLSLVHCCVNPVLYSFINRNYR 323
Cdd:cd15977 240 LSRILKKTIYDVKDPQRCELLSFLLVMDYTGINMASLNSCINPVALYFVSRKFK 293
7tmA_Vasopressin_Oxytocin cd15196
vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G ...
53-326 1.14e-15

vasopressin and oxytocin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) and oxytocin are synthesized in the hypothalamus and are released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320324 [Multi-domain]  Cd Length: 264  Bit Score: 76.12  E-value: 1.14e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  53 FIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWV----VLTIPVWVVSLVQHNqwpmGELTCKVTHLIFSINL 128
Cdd:cd15196   9 TILVLALFGNSCVLLVLYRRRRKLSRMHLFILHLSVADLLValfnVLPQLIWDITYRFYG----GDLLCRLVKYLQVVGM 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 129 FGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCIlVWLLAFCVSLPDtYYLKTVTSASNNETYCRSFYPEHSIKEW 208
Cdd:cd15196  85 YASSYVLVATAIDRYIAICHPLSSHRWTSRRVHLMVAI-AWVLSLLLSIPQ-LFIFSYQEVGSGVYDCWATFEPPWGLRA 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 209 LIGMELVSVvlgFAVPFSIIAVFYFLLARAISASsdqeKHSSRKIIFSYVVVFLVCWLPYHVAVLLDIFSilhyipftcr 288
Cdd:cd15196 163 YITWFTVAV---FVVPLIILAFCYGRICYVVWRA----KIKTVKLTLVVVACYIVCWTPFFVVQMWAAWD---------- 225
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 31083344 289 lEHALFTALHVTQCLSL--VHCCVNPVLYSFINRNYRYEL 326
Cdd:cd15196 226 -PTAPIEGPAFVIIMLLasLNSCTNPWIYLAFSGNLRRAL 264
7tmA_NK1R cd16002
neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled ...
51-323 1.59e-15

neurokinin 1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The neurokinin 1 receptor (NK1R), also known as tachykinin receptor 1 (TACR1) or substance P receptor (SPR), is a G-protein coupled receptor found in the mammalian central nervous and peripheral nervous systems. The tachykinins act as excitatory transmitters on neurons and cells in the gastrointestinal tract. The TKs are characterized by a common five-amino acid C-terminal sequence, Phe-X-Gly-Leu-Met-NH2, where X is a hydrophobic residue. The three major mammalian tachykinins are substance P (SP), neurokinin A (NKA), and neurokinin B (NKB). The physiological actions of tachykinins are mediated through three types of receptors: neurokinin receptor type 1 (NK1R), NK2R, and NK3R. SP is a high-affinity endogenous ligand for NK1R, which interacts with the Gq protein and activates phospholipase C, leading to elevation of intracellular calcium. SP is an extremely potent vasodilator through endothelium dependent mechanism and is released from the autonomic sensory nerves. NK2R is a high-affinity receptor for NKA, the tachykinin neuropeptide substance K. SP and NKA are found in the enteric nervous system and mediate in the regulation of gastrointestinal motility, secretion, vascular permeability, and pain perception.


Pssm-ID: 320668 [Multi-domain]  Cd Length: 284  Bit Score: 76.06  E-value: 1.59e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  51 YIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVtHLIFSIN-LF 129
Cdd:cd16002   7 YSVIVVVSVVGNIIVMWIILAHKRMRTVTNYFLVNLAFAEASMSAFNTVINFTYAIHNEWYYGLEYCKF-HNFFPIAaVF 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 130 GSIFFLTCMSVDRYLSITYFTNtPSSRKKMVRRVVCIlVWLLAFCVSLPDTYYLKTVTSASNneTYCRSFYPEHSIKEWL 209
Cdd:cd16002  86 ASIYSMTAIALDRYMAIIHPLQ-PRLSATATKVVICV-IWVLAFLLAFPQGYYSDTEEMPGR--VVCYVEWPEHEERKYE 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 210 IGMELVSVVLGFAVPFSIIAVFYF-----LLARAISASSDQEKHSS----RKIIFSYVVV---FLVCWLPYHVAVLLDIF 277
Cdd:cd16002 162 TVYHVCVTVLIYFLPLLVIGCAYTvvgitLWASEIPGDSSDRYHEQvsakRKVVKMMIVVvctFAICWLPYHIYFLLQYF 241
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 31083344 278 SILHYipftcrlEHALFTALHVT-QCLSLVHCCVNPVLYSFINRNYR 323
Cdd:cd16002 242 HPELY-------EQKFIQQVYLAiMWLAMSSTMYNPIIYCCLNDRFR 281
7tmA_Histamine_H3R_H4R cd15048
histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G ...
46-324 1.83e-15

histamine receptor subtypes H3R and H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H4R, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320176 [Multi-domain]  Cd Length: 296  Bit Score: 75.80  E-value: 1.83e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  46 TLSFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWV-VLTIPVWVVSLVQhNQWPMGELTCKVTHLIF 124
Cdd:cd15048   2 VLAVLISVLILVTVIGNLLVILAFIKDKKLRTVSNFFLLNLAVADFLVgLVSMPFYIPYTLT-GKWPFGKVFCKAWLVVD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 125 SINLFGSIFFLTCMSVDRYLSITYftNTPSSRKKMVRRVVCIL--VWLLAFCVSLPDTYYLKTVTSASNNETY-CRSFYP 201
Cdd:cd15048  81 YTLCTASALTIVLISLDRYLSVTK--AVKYRAKQTKRRTVLLMalVWILAFLLYGPAIIGWDLWTGYSIVPTGdCEVEFF 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 202 EHsikeWLIgmELVSVVLGFAVPFSIIAVFYFLL-------ARAISASSDQEKHSSR---------------------KI 253
Cdd:cd15048 159 DH----FYF--TFITSVLEFFIPFISVSFFNLLIylnirkrSRRRPLRSVPILPASQnpsrarsqreqvklrrdrkaaKS 232
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 31083344 254 IFSYVVVFLVCWLPYHVAVLLDIFsilhyipftCRLEHALFTALHVTQCLSLVHCCVNPVLYSFINRNYRY 324
Cdd:cd15048 233 LAILVLVFLICWAPYTILTIIRSF---------CSGSCVDSYLYEFTFWLLWTNSAINPFLYAACHPRFRK 294
7tmA_MCHR1 cd15338
melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane ...
50-326 1.87e-15

melanin concentrating hormone receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320460 [Multi-domain]  Cd Length: 282  Bit Score: 75.62  E-value: 1.87e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  50 IYIFIFVIGMIANSVVVWVNIQAKTTGYDTHC---YILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVTHLIFSI 126
Cdd:cd15338   6 VFGVICFLGIIGNSIVIYTIVKKSKFRCQQTVpdiFIFNLSIVDLLFLLGMPFLIHQLLGNGVWHFGETMCTLITALDTN 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 127 NLFGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDTYYLKTVtSASNNETYCRSFYPEHSIK 206
Cdd:cd15338  86 SQITSTYILTVMTLDRYLATVHPIRSTKIRTPRVAVAVICLVWILSLLSITPVWMYAGLM-PLPDGSVGCALLLPNPETD 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 207 ewLIGMELVSVVLGFAVPFSIIAVFYF-LLARAISASSDQEKHSSR-------KIIFSYVVVFLVCWLPYHVAVLLDIfs 278
Cdd:cd15338 165 --TYWFTLYQFFLAFALPLVVICVVYFkILQNMASTVAPLPQRSLRvrtkkvtRMAVAICLAFFICWAPFYILQLAHL-- 240
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 31083344 279 ilhyipFTCRLEHALFTALHVTQCLSLVHCCVNPVLYSFINRNYRYEL 326
Cdd:cd15338 241 ------SIDRPSLAFLYAYNVAISMGYANSCINPFLYIMLSETFKRQF 282
7tmA_NPFFR2 cd15980
neuropeptide FF receptor 2, member of the class A family of seven-transmembrane G ...
51-323 2.12e-15

neuropeptide FF receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320646 [Multi-domain]  Cd Length: 299  Bit Score: 75.69  E-value: 2.12e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  51 YIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWV-VLTIPVWVVSLVQHNqWPMGELTCKVTHLIFSINLF 129
Cdd:cd15980   7 YLLIFLLCMMGNGVVCFIVLRSKHMRTVTNLFILNLAISDLLVgIFCMPTTLLDNIIAG-WPFGSTVCKMSGMVQGISVS 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 130 GSIFFLTCMSVDRYLSITYftntPSSRKKMVRRVVCILV--WLLAFCVSLPDTYYLKT-------VTSASNNET----YC 196
Cdd:cd15980  86 ASVFTLVAIAVDRFRCIVY----PFKQKLTISTAVVIIViiWVLAIAIMCPSAVMLHVqeeknyrVVLGSQNKTspvyWC 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 197 RSFYPEHSIKEWLIGMELVSVVLGfavPFSIIAVFY-------FLLARAISASSDQEKHSS-----RKIIFSYVVV---F 261
Cdd:cd15980 162 REDWPNQEMRKIYTTVLFANIYLA---PLSLIVIMYarigitlFKTAMPHTGKHNQEQRHVvsrkkQKVIKMLLIVallF 238
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 31083344 262 LVCWLPYHVAVLLDIFSILHYIPFTCrLEHALFTALHvtqCLSLVHCCVNPVLYSFINRNYR 323
Cdd:cd15980 239 ILSWLPLWTLMMLSDYANLSPNQLQI-INIYIYPFAH---WLAFFNSSVNPIIYGFFNENFR 296
7tmA_D1-like_dopamine_R cd15057
D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G ...
59-330 7.73e-15

D1-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. The D1-like family receptors are coupled to G proteins of the G(s) family, which activate adenylate cyclase, causing cAMP formation and activation of protein kinase A. In contrast, activation of D2-like family receptors is linked to G proteins of the G(i) family, which inhibit adenylate cyclase. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320185 [Multi-domain]  Cd Length: 299  Bit Score: 74.00  E-value: 7.73e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  59 MIANSVVVWVNIQAKTTGYdthcYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELtCKVtHLIFSI-NLFGSIFFLTC 137
Cdd:cd15057  20 LVIAAVLRFRHLRSKVTNY----FIVSLAVSDLLVAILVMPWAAVNEVAGYWPFGSF-CDV-WVSFDImCSTASILNLCV 93
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 138 MSVDRYLSITyftNTPSSRKKMVRRVVCIL---VWLLAFCVS-LP-DTYYLKTVTSASNNETYCRSFYPEHSIKEWligM 212
Cdd:cd15057  94 ISVDRYWAIS---SPFRYERRMTRRRAFIMiavAWTLSALISfIPvQLGWHRADDTSEALALYADPCQCDSSLNRT---Y 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 213 ELVSVVLGFAVPFSIIAVFY---FLLARAI-------------SASSDQEKHSS----RKIIFSYVV---VFLVCWLPYH 269
Cdd:cd15057 168 AISSSLISFYIPVAIMIVTYtriYRIARRQirriaaleraaqeSTNPDSSLRSSlrreTKALKTLSIimgVFVCCWLPFF 247
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 31083344 270 VAVLLDIFSILHYIPFTCrLEHALFTalhVTQCLSLVHCCVNPVLYSFiNRNYRyelmKAF 330
Cdd:cd15057 248 ILNCVLPFCDLRTAQFPC-VPDTTFI---VFVWLGWANSSLNPIIYAF-NADFR----KAF 299
7tmA_Dop1R2-like cd15067
dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the ...
79-323 8.60e-15

dopamine 1-like receptor 2 from Drosophila melanogaster and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled dopamine 1-like receptor 2 is expressed in Drosophila heads and it shows significant sequence similarity with vertebrate and invertebrate dopamine receptors. Although the Drosophila Dop1R2 receptor does not cluster into the D1-like structural group, it does show pharmacological properties similar to D1-like receptors. As shown in vertebrate D1-like receptors, agonist stimulation of Dop1R2 activates adenylyl cyclase to increase cAMP levels and also generates a calcium signal through stimulation of phospholipase C.


Pssm-ID: 320195 [Multi-domain]  Cd Length: 262  Bit Score: 73.54  E-value: 8.60e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  79 THCYILNLAIADLWV-VLTIPVWVVSLVQHNQWPMGELTCKVTHLIFSINLFGSIFFLTCMSVDRYLSITYFTNTPSSRK 157
Cdd:cd15067  34 TNYFIVSLAVADLLVgSIVMPFSILHEMTGGYWLFGRDWCDVWHSFDVLASTASILNLCVISLDRYWAITDPISYPSRMT 113
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 158 KMVRRVVCILVWLLAFCVSLPDTYYLKTVTSASNNETYCrsFYPEHSIkeWLIGMELVSvvlgFAVPFSIIAVFYFLLAR 237
Cdd:cd15067 114 KRRALIMIALVWICSALISFPAIAWWRAVDPGPSPPNQC--LFTDDSG--YLIFSSCVS----FYIPLVVMLFTYYRIYR 185
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 238 AisASSDQEKHSSRKIIfsyVVVFLVCWLPYHVAVLLDIFSilhyiPFTCrLEHALFTALHVTQcLSLVHCCVNPVLYSF 317
Cdd:cd15067 186 A--AAKEQKAAKTLGIV---MGVFILCWLPFFVTNILIGFC-----PSNC-VSNPDILFPLVTW-LGYINSGMNPIIYAC 253

                ....*.
gi 31083344 318 INRNYR 323
Cdd:cd15067 254 SSRDFR 259
7tmA_NPY2R cd15399
neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G ...
46-324 9.24e-15

neuropeptide Y receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320521 [Multi-domain]  Cd Length: 285  Bit Score: 73.70  E-value: 9.24e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  46 TLSFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWV-VLTIPVWVVSLVQhNQWPMGELTCKVTHLIF 124
Cdd:cd15399   2 VLILAYCSIILLGVVGNSLVIYVVIKFKNMRTVTNFFIANLAVADLMVnTLCLPFTLVYTLL-DEWKFGAVLCHLVPYAQ 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 125 SINLFGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVrrVVCILVWLLAFCVSLPDTY---YLKTVTSASNNETYCRSFYP 201
Cdd:cd15399  81 ALAVHVSTVTLTVIALDRHRCIVYHLESKISKKISF--LIIGLTWAASALLASPLAIfreYSVIEISPDFKIQACSEKWP 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 202 EHSIKEWLIgMELVSVVLGFAVPFSIIAVFYFL----LARAISASSDQEKHSSR-----KIIFSYVVVFLVCWLPYHVAV 272
Cdd:cd15399 159 NGTLNDGTI-YSVSMLLIQYVLPLAIISYAYIRiwtkLKNHVSPGGGNDHYHQRrrkttKMLVCVVVVFAVSWLPFHAFQ 237
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 31083344 273 L-LDIFSILhyipFTCRLEHALFTALHVtqcLSLVHCCVNPVLYSFINRNYRY 324
Cdd:cd15399 238 LaSDIDSKV----LDLKEYKLIYTIFHV---IAMCSTFANPLLYGWMNNNYRT 283
7tmA_Peropsin cd15073
retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of ...
52-323 9.50e-15

retinal pigment epithelium-derived rhodopsin homolog, member of the class A family of seven-transmembrane G protein-coupled receptors; Peropsin, also known as a retinal pigment epithelium-derived rhodopsin homolog (RRH), is a visual pigment-like protein found exclusively in the apical microvilli of the retinal pigment epithelium. Peropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Peropsin presumably plays a physiological role in the retinal pigment epithelium either by detecting light directly or monitoring the levels of retinoids, the primary light absorber in visual perception, or other pigment-related compounds in the eye.


Pssm-ID: 320201 [Multi-domain]  Cd Length: 280  Bit Score: 73.62  E-value: 9.50e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  52 IFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWV-VLTIPVWVVSLVqHNQWPMGELTCKVthLIFSINLFG 130
Cdd:cd15073   8 IVAGIISTISNGIVLVTFVKFRELRTPTNALIINLAVTDLGVsIIGYPFSAASDL-HGSWKFGYAGCQW--YAFLNIFFG 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 131 --SIFFLTCMSVDRYLSITyftnTPSSRKKMVRR---VVCILVWLLAF-----------CVSLPDTYYLKTVTSASNNET 194
Cdd:cd15073  85 maSIGLLTVVAVDRYLTIC----RPDLGRKMTTNtytVMILLAWTNAFfwaamplvgwaSYALDPTGATCTINWRKNDSS 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 195 YcrsfypehsikewlIGMELVSVVLGFAVPFSIIAVFYFLLARAISASSDQEKHSSRKIIFSY-----------VVVFLV 263
Cdd:cd15073 161 F--------------VSYTMSVIVVNFIVPLAVMFYCYYNVSRFVKKVLASDCLESVNIDWTDqndvtkmsvimIVMFLV 226
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 264 CWLPYHVAVLLDIFSILHYIPFTCRLEHALFTAlhvtqclslVHCCVNPVLYSFINRNYR 323
Cdd:cd15073 227 AWSPYSIVCLWASFGEPKKIPPWMAIIPPLFAK---------SSTFYNPCIYVIANKKFR 277
7tmA_PrRP_R cd15394
prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G ...
51-326 9.60e-15

prolactin-releasing peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prolactin-releasing peptide (PrRP) receptor (previously known as GPR10) is expressed in the central nervous system with the highest levels located in the anterior pituitary and is activated by its endogenous ligand PrRP, a neuropeptide possessing a C-terminal Arg-Phe-amide motif. There are two active isoforms of PrRP in mammals: one consists of 20 amino acids (PrRP-20) and the other consists of 31 amino acids (PrRP-31), where PrRP-20 is a C-terminal fragment of PrRP-31. Binding of PrRP to the receptor coupled to G(i/o) proteins activates the extracellular signal-related kinase (ERK) and it can also couple to G(q) protein leading to an increase in intracellular calcium and activation of c-Jun N-terminal protein kinase (JNK). The PrRP receptor shares significant sequence homology with the neuropeptide Y (NPY) receptor, and micromolar levels of NPY can bind and completely inhibit the PrRP-evoked intracellular calcium response in PrRP receptor-expressing cells, suggesting that the PrRP receptor shares a common ancestor with the NPY receptors. PrRP has been shown to reduce food intake and body weight and modify body temperature when administered in rats. It also has been shown to decrease circulating growth hormone levels by activating somatostatin-secreting neurons in the hypothalamic periventricular nucleus.


Pssm-ID: 320516 [Multi-domain]  Cd Length: 286  Bit Score: 73.62  E-value: 9.60e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  51 YIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLT-IPVWVVSLVQHNQWPMGELTCKVTHLIFSINLF 129
Cdd:cd15394   7 YSLVVLVGVVGNYLLIYVICRTKKMHNVTNFLIGNLAFSDMLMCATcVPLTLAYAFEPRGWVFGRFMCYFVFLMQPVTVY 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 130 GSIFFLTCMSVDRYLSITYftntPSSRKKMVRRVVCIL--VWLLAFCVSLPDTYYLKTVTSASNNETYCRSFYpEHSIKE 207
Cdd:cd15394  87 VSVFTLTAIAVDRYYVTVY----PLRRRISRRTCAYIVaaIWLLSCGLALPAAAHTYYVEFKGLDFSICEEFW-FGQEKQ 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 208 WLI---GMELVSVVLGF-AVPFSIIAVFYFLLARAISAS---SDQEKHSSRK-----IIFSYVVVFLVCWLPYHVAVL-- 273
Cdd:cd15394 162 RLAyacSTLLITYVLPLlAISLSYLRISVKLRNRVVPGSmtqSQAEWDRARRrktfrLLVVVVVAFAICWLPLHIFNVir 241
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 31083344 274 -LDIFSILHY----IPFTCRLehalftalhvtqcLSLVHCCVNPVLYSFINRNYRYEL 326
Cdd:cd15394 242 dIDIDLIDKQyfnlIQLLCHW-------------LAMSSACYNPFLYAWLHDSFRGEL 286
7tmA_HCAR1-3 cd15201
hydroxycarboxylic acid receptors, member of the class A family of seven-transmembrane G ...
45-317 1.46e-14

hydroxycarboxylic acid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Hydroxycarboxylic acid receptor (HCAR) subfamily, a member of the class A G-protein coupled receptors (GPCRs), contains three receptor subtypes: HCAR1, HCAR2, and HCAR3. The endogenous ligand of HCAR1 (also known as lactate receptor 1, GPR104, or GPR81) is L-lactic acid. The endogenous ligands of HCAR2 (also known as niacin receptor 1, GPR109A, or nicotinic acid receptor) and HCAR3 (also known as niacin receptor 2 or GPR109B) are 3-hydroxybutyric acid and 3-hydroxyoctanoic acid, respectively. Because nicotinic acid is capable of stimulating HCAR2 at higher concentrations only (in the range of sub-micromolar concentration), it is unlikely that nicotinic acts as a physiological ligand of HCAR2. All three receptors are expressed in adipocytes and mediate anti-lipolytic effects in fat cells through G(i) type G protein-dependent inhibition of adenylate cyclase.


Pssm-ID: 320329 [Multi-domain]  Cd Length: 281  Bit Score: 73.16  E-value: 1.46e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  45 YTLSFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVTHLIF 124
Cdd:cd15201   1 YVLPPVLILEFVLGLLGNGLALWIFCFHLKSWKSSTVYLFNLAVADFLLIICLPFRTDYYLRGKHWKFGDIPCRIVLFML 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 125 SINLFGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLL-----AFCVSLPDTYYlktvtsaSNNETYCRSF 199
Cdd:cd15201  81 AMNRAGSIFFLTAVAVDRYFRVVHPHHRINSISVRKAAIIACGLWLLtiamtVYLLTKKHLFP-------RGNATQCESF 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 200 ----YPEHSIKeWLIGMELVSvvlgFAVPFSIIAVFYFLLARAISASS-DQEKHSSRKIIFSYVV--VFLVCWLPYHVAV 272
Cdd:cd15201 154 nictGTDSSSN-WHEAMFLLE----FFLPLAIILYCSVRIIWQLRGRQlDRHAKIKRAVQFIMVVaiVFIICFLPSNVTR 228
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 31083344 273 LLdIFSILHYIPFTCRLEHALFTALHVTQCLSLVHCCVNPVLYSF 317
Cdd:cd15201 229 IA-IWILKHTSNEDCQYYRSVDLAFYITISFTYFNSMLDPVVYYF 272
7tmA_NPR-like_invertebrate cd15391
invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G ...
41-326 1.51e-14

invertebrate neuropeptide receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor found in invertebrates, which is a member of class A of 7-transmembrane G protein-coupled receptors. This orphan receptor shares a significant amino acid sequence identity with the neurokinin 1 receptor (NK1R). The endogenous ligand for NK1R is substance P, an 11-amino acid peptide that functions as a vasodilator and neurotransmitter and is released from the autonomic sensory nerve fibers.


Pssm-ID: 320513 [Multi-domain]  Cd Length: 289  Bit Score: 73.32  E-value: 1.51e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  41 SVLLYTlsfIYIFIFVIGmiaNSVVVWVNIQAKTTGYDTHCYILNLAIADLWV-VLTIPVWVVSLVQHNqWPMGELTCKV 119
Cdd:cd15391   3 LINLYQ---STIFLSVGG---NYSVIVVFYDGRRSRTDLNYYLINLAVSDLIMaLFCMPFTFTQIMLGH-WVFPAPMCPI 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 120 THLIFSINLFGSIFFLTCMSVDRYLSITYftntPSSRKKMVRRVVCI--LVWLLAFCVSLPDTYYLKTVTSASNNETY-- 195
Cdd:cd15391  76 VLYVQLVSVTASVLTNTAIGIDRFFAVIF----PLRSRHTKSRTKCIiaSIWAISFSLSSVQLFAGRTQRYGQYSEGRvl 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 196 CRSFYPEHSikEWLIGMELVSVVLGFAVPFSIIAVFYFLLAR----------AISASSDQEKHSSRKIIFSYVVV---FL 262
Cdd:cd15391 152 CGESWPGPD--TSRSAYTVFVMLLTYIIPLLILTSTYGYVGFrlwnrtapgnADKGRDDMQIKSKRKVIKMLVFVvlmFG 229
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 31083344 263 VCWLPYHVAVLLDIFSILhYIPFTCRLEHALFTALHvtqCLSLVHCCVNPVLYSFINRNYRYEL 326
Cdd:cd15391 230 ICWLPLHLFNLVQDFSTV-FRNMPQHTTRLIYGACH---WIAMSNSFVNPIIYLFMNDSFRSIL 289
7tmA_GPR82 cd14996
orphan G protein-coupled receptor 82, member of the class A family of seven-transmembrane G ...
47-323 1.58e-14

orphan G protein-coupled receptor 82, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the G-protein coupled receptor 82 of unknown function. GPR82 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320127 [Multi-domain]  Cd Length: 305  Bit Score: 73.30  E-value: 1.58e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  47 LSFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVTH----L 122
Cdd:cd14996   3 LPIIYSFLFVTGVFGNLLSLWVFLTKISKKTSTHIYLINLVTANLLVCSAMPFQAAYFLKGFYWKYQSTQCRIANffgtL 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 123 IFSINLFGSIFFLTCMSVDRYLSI---TYFTNTPSSRKKMV-------------RRVVCILVWLLAFCVSLPDTYYLKTV 186
Cdd:cd14996  83 VIHVSMCVSILILSWIAISRYATLmkhDSATQKQSCYEKIFyghflkrfrqpkfARYLCIYIWGVVLCIIIPVVVYYSVR 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 187 TSASNNETYCRSFYPEHSIKEWLIgMELVSVVLGFAVPFSIIAVFYFL---LARAISASSDQEKHSSRKIIFSYVV---- 259
Cdd:cd14996 163 EADEDGESLCYNRQVELGAKGSQI-AGLIATTFFFLFFLVVLLSYYSFvnhLRRIQKNTCISEKDLIYRSVKRNILiiqa 241
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 31083344 260 VFLVCWLPYHVAVLldIFSILHYIPfTCRLEHALFTALHVTQCLSLVHCCVNPVLYSFINRNYR 323
Cdd:cd14996 242 LLVVCFLPYHIFKP--VFYVLHQRE-DCQQLNYLIETKNILTCLASARSSTDPIMYLLLDKTFK 302
7tmA_FFAR2_FFAR3 cd15170
free fatty acid receptors 2, 3, and similar proteins, member of the class A family of ...
49-270 2.53e-14

free fatty acid receptors 2, 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes free fatty acid receptor 2 (FFAR2), FFAR3, and similar proteins. They are a member of the class A G-protein coupled receptors that bind free fatty acids. The FFAR subfamily is composed of three receptors, each encoded by a separate gene (FFAR1, FFAR2, and FFAR3). These genes and a fourth pseudogene, GPR42, are localized together on chromosome 19. FFAR2 and FFAR3 are cell-surface receptors for short chain FFAs (SCFAs) with different ligand affinities, whereas FFAR1 is a receptor for medium- and long-chain FFAs. FFAR2 activation by SCFA suppresses adipose insulin signaling, which leads to inhibition of fat accumulation in adipose tissue. FAAR3 is expressed in intestinal L cells, which produces glucagon-like peptide 1 (GLP-1) and peptide YY (PYY), thus suggesting that this receptor may be involved in energy homeostasis. FFARs are considered important components of the body's nutrient sensing mechanism, and therefore, these receptors are potential therapeutic targets for the treatment of metabolic disorders, such as type 2 diabetes and obesity.


Pssm-ID: 320298  Cd Length: 278  Bit Score: 72.29  E-value: 2.53e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  49 FIYIFIFVIGMIAN---SVVVWVNIQAKTTGYDThcYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVTHLIFS 125
Cdd:cd15170   5 AVYIITFLIGLPANllaFYTFIRKVRRKPTPIDI--LLLNLTVSDLIFLLFLPFKMAEAASGMIWPLPYFLCPLSSFIFF 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 126 INLFGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAF---CVSLPDTYYLKTVTSASNNETYCRSFYPE 202
Cdd:cd15170  83 STIYISTLFLTAISVERYLGVAFPIKYKLRRRPLYAVIASVFFWVLAFshcSIVYIVEYHIDSENTSVTNNSRCYDNFTP 162
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 31083344 203 HSIKEWL-IGMELVsVVLgFAVPFSIIAVFYFLLARAISASSDQEKHSSRKII---FSYVVVFLVCWLPYHV 270
Cdd:cd15170 163 EQLKILLpVRLELF-LVL-FCIPFLITCFCYINFIRILSSLPHISRQRKQRAIglaVATLLNFIVCFAPYNI 232
7tmA_FMRFamide_R-like cd14978
FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...
48-323 2.78e-14

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.


Pssm-ID: 410630 [Multi-domain]  Cd Length: 299  Bit Score: 72.28  E-value: 2.78e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  48 SFIYIFIFVIGMIANSVVVWVnIQAKTTGYDTHCYILNLAIADLwVVLTIPVWVVSLVQHNQWPMGELT------CKVTH 121
Cdd:cd14978   4 GYVLPVICIFGIIGNILNLVV-LTRKSMRSSTNVYLAALAVSDI-LVLLSALPLFLLPYIADYSSSFLSyfyayfLPYIY 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 122 LIFSINLFGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDTYYLKTVTSASNNETYCRSFYP 201
Cdd:cd14978  82 PLANTFQTASVWLTVALTVERYIAVCHPLKARTWCTPRRARRVILIIIIFSLLLNLPRFFEYEVVECENCNNNSYYYVIP 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 202 EHSIKE---WLIGMELVSVVLGFAVPFSIIAVFYFLLARAI-----------SASSDQEKHSSR-----KIIFSYVVVFL 262
Cdd:cd14978 162 TLLRQNetyLLKYYFWLYAIFVVLLPFILLLILNILLIRALrkskkrrrllrRRRRLLSRSQRRerrttIMLIAVVIVFL 241
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 31083344 263 VCWLPYHvavlldIFSILHYIPFTCRLEHALFTALHVTQCLSLVHCCVNPVLYSFINRNYR 323
Cdd:cd14978 242 ICNLPAG------ILNILEAIFGESFLSPIYQLLGDISNLLVVLNSAVNFIIYCLFSSKFR 296
7tmA_ET_R cd15128
endothelin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
45-323 3.49e-14

endothelin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are 21-amino acid peptides which able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320256 [Multi-domain]  Cd Length: 300  Bit Score: 72.17  E-value: 3.49e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  45 YTLSFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIAD-LWVVLTIPVWVVSLVQhNQWP-----MGELTCK 118
Cdd:cd15128   1 YINTVVSCLIFIVGIIGNSTLLRIIYQNKCMRNGPNALIASLALGDlLYIVIDLPINVYKLLA-MDWPfgdqpFGQFLCK 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 119 VTHLIFSINLFGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDTYYLKTVTSASNNETYCRS 198
Cdd:cd15128  80 LVPFIQKASVGITVLNLCALSVDRYRAVASWSRIQGIGIPMWTAVEIVMIWMLSAVLAVPEAIGFDMVRFNYKGVTLRTC 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 199 F-YPEHSIKE--------WLIGMElvsvvlgFAVPFSIIAVFYFL------------LARAISASSDQEKHSSrKIIFSY 257
Cdd:cd15128 160 LlRPETSFMKfyidvkdwWLFGFY-------FCLPLVCTAIFYTLmtcemlrkrngmLRIALNEHLKQRREVA-KTVFCL 231
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 31083344 258 VVVFLVCWLPYHVAVLLDIFSILHYIPFTCRLEHALFTALHVTQCLSLVHCCVNPVLYSFINRNYR 323
Cdd:cd15128 232 VVIFALCWLPLHLSRILKLTVYDQNDPNRCELLSFLLVLDYFGINLATLNSCINPIALYFVSRKFK 297
7tmA_TAARs cd15055
trace amine-associated receptors, member of the class A family of seven-transmembrane G ...
79-323 1.05e-13

trace amine-associated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptors (TAARs) are a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320183 [Multi-domain]  Cd Length: 285  Bit Score: 70.66  E-value: 1.05e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  79 THCYILNLAIADLWV-VLTIPVWVVSLVQHNqWPMGELTCKVTHLIFSINLFGSIFFLTCMSVDRYLSITYFTNTPSsrk 157
Cdd:cd15055  35 TNLLLLSLAVADFLVgLLVMPFSMIRSIETC-WYFGDTFCKLHSSLDYILTSASIFNLVLIAIDRYVAVCDPLLYPT--- 110
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 158 KMVRRVVCILV---WLLAFCVSLPdTYYLKTVTSASNNETYCRSFYPEHSIKEWLIgmelVSVVLGFAVPFSIIAVFY-- 232
Cdd:cd15055 111 KITIRRVKICIclcWFVSALYSSV-LLYDNLNQPGLIRYNSCYGECVVVVNFIWGV----VDLVLTFILPCTVMIVLYmr 185
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 233 -FLLA----RAISASSDQ------EKHSSRK----------IIfsyVVVFLVCWLPYHVAVLLDIFSILhyipftcrleh 291
Cdd:cd15055 186 iFVVArsqaRAIRSHTAQvslegsSKKVSKKserkaaktlgIV---VGVFLLCWLPYYIVSLVDPYIST----------- 251
                       250       260       270
                ....*....|....*....|....*....|..
gi 31083344 292 aLFTALHVTQCLSLVHCCVNPVLYSFINRNYR 323
Cdd:cd15055 252 -PSSVFDVLIWLGYFNSCLNPLIYALFYPWFR 282
7tmA_D3_dopamine_R cd15310
D3 subtype of the D2-like family of dopamine receptors, member of the class A family of ...
45-323 1.70e-13

D3 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320436 [Multi-domain]  Cd Length: 259  Bit Score: 69.61  E-value: 1.70e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  45 YTLSFIYIFIFVIgmIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSL-VQHNQWPMGELTCKVTHLI 123
Cdd:cd15310   3 YALSYCALILAIV--FGNVLVCMAVLRERALQTTTNYLVVSLAVADLLVATLVMPWVVYLeVTGGVWNFSRICCDVFVTL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 124 FSINLFGSIFFLTCMSVDRYLSIT----YFTNTPSSRKKMVRrVVCILVWLLAFCVSLPDTYYLKTvtsaSNNETYCRSF 199
Cdd:cd15310  81 DVMMCTASILNLCAISIDRYTAVVmpvhYQHGTGQSSCRRVS-LMITAVWVLAFAVSCPLLFGFNT----TGDPTVCSIS 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 200 YPEhsikeWLIGMELVSVVLGFAVPFSIIAVFYFLLARAISASsdqekhssrKIIFSYVVVFLVCWLPyhvavlldiFSI 279
Cdd:cd15310 156 NPD-----FVIYSSVVSFYLPFGVTLLVYVRIYVVLLREKKAT---------QMLAIVLGAFIVCWLP---------FFL 212
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 31083344 280 LHYIPFTCRLEHALFTALHVTQCLSLVHCCVNPVLYSFINRNYR 323
Cdd:cd15310 213 THILNTHCQACHVPPELYSATTWLGYVNSALNPVIYTTFNIEFR 256
7tmA_GPR150 cd15198
G protein-coupled receptor 150, member of the class A family of seven-transmembrane G ...
47-321 2.30e-13

G protein-coupled receptor 150, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR150 is an orphan receptor closely related to the oxytocin and vasopressin receptors. Its endogenous ligand is not known. These receptors share a significant amino acid sequence similarity, suggesting that they have a common evolutionary origin.


Pssm-ID: 320326 [Multi-domain]  Cd Length: 299  Bit Score: 69.84  E-value: 2.30e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  47 LSFIYIfIFVIGMIAN-SVVVWVNI-QAKTTGYDThcYILNLAIADL----WVVLTIPVWvvSLVQhNQWPMGELTCKVT 120
Cdd:cd15198   4 LIFLGV-ILVAGVAGNtTVLCWLCGgRRRKSRMNF--LLLQLALADLlvigGTALSQIIW--ELLG-DRWMAGDVACRLL 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 121 HLIFSINLFGSIFFLTCMSVDRYLSItyftNTPSSRKKMVRRVVcILVWLLAFCVSLPDTYYLKTV-----TSASNNETY 195
Cdd:cd15198  78 KLLQASARGASANLVVLLALDRHQAI----RAPLGQPLRAWKLA-ALGWLLALLLALPQAYVFRVDfpddpASAWPGHTL 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 196 CRSFYpeHSIKEWLIGMELVSV-VLGFAVPFSIIAVFYFLL----ARAISASSDQE----------------------KH 248
Cdd:cd15198 153 CRGIF--APLPRWHLQVYATYEaVVGFVAPVVILGVCYGRLllkwWERANQAPGAKkpwkkpskshlratapsalpraKV 230
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 31083344 249 SSRKIIFSYVVVFLVCWLPYHVAVLLDIFSILHYIPftcrleHALFTALHVtqcLSLVHCCVNPVLYSFINRN 321
Cdd:cd15198 231 KTLKMTLVIALLFVGCSLPYFIAELAAAFGSGDWEP------EKVAAALGV---MAVANSATNPFVFLFFNAG 294
7tmA_PSP24-like cd15213
G protein-coupled receptor PSP24 and similar proteins, member of the class A family of ...
46-323 2.92e-13

G protein-coupled receptor PSP24 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes two human orphan receptors, GPR45 and GPR65, and their closely related proteins found in vertebrates and invertebrates. GPR45 and GPR 65 are also called PSP24-alpha (or PSP24-1) and PSP24-beta (or PSP24-2) in other vertebrates, respectively. These receptors exhibit the highest sequence homology to each other. PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Instead, sphingosine 1-phosphate and dioleoylphosphatidic acid have been shown to act as low affinity agonists for GPR63. PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320341 [Multi-domain]  Cd Length: 262  Bit Score: 68.93  E-value: 2.92e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  46 TLSFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIAD-LWVVLTIPVWVVSLVQHNqWPMGELTCKVTHLIF 124
Cdd:cd15213   2 TLAILMILMIFVGFLGNSIVCLIVYQKPAMRSAINLLLANLAFSDiMLSLVCMPFAAVTIITGR-WIFGDIFCRISAMLY 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 125 SINLFGSIFFLTCMSVDRYLSITYFTNTPSSRKKmvrRVVCILVWLLAFCVSLPDTYYLKTVTSASnNETYCRSFYPEHS 204
Cdd:cd15213  81 WFFVLEGVAILLIISVDRYLIIVQRQDKLNPHRA---KILIAVSWVLSFCVSFPPLVGWGKYEFPP-RAPQCVLGYTESP 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 205 IKEWLIGMELVSVvlgFAVPFSIIAVFYFLLARAISASsdqeKHSSRKIIFSYVVVFLVCWLPYHVAVLLDIFSilhyip 284
Cdd:cd15213 157 ADRIYVVLLLVAV---FFIPFLIMLYSYFCILNTVRSF----KTRAFTTILILFIGFSVCWLPYTVYSLLSVFS------ 223
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 31083344 285 ftcRLEHALFTALHVTQCLSLVHCCVNPVLYSFINRNYR 323
Cdd:cd15213 224 ---RYSSSFYVISTCLLWLSYLKSAFNPVIYCWRIKKFR 259
7tmA_TRH-R cd14995
thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G ...
46-323 3.71e-13

thyrotropin-releasing hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; TRH-R is a member of the class A rhodopsin-like G protein-coupled receptors, which binds the tripeptide thyrotropin releasing hormone. The TRH-R activates phosphoinositide metabolism through a pertussis-toxin-insensitive G-protein, the G(q)/G(11) class. TRH stimulates the synthesis and release of thyroid-stimulating hormone in the anterior pituitary. TRH is produced in many other tissues, especially within the nervous system, where it appears to act as a neurotransmitter/neuromodulator. It also stimulates the synthesis and release of prolactin. In the CNS, TRH stimulates a number of behavioral and pharmacological actions, including increased turnover of catecholamines in the nucleus accumbens. There are two thyrotropin-releasing hormone receptors in some mammals, thyrotropin-releasing hormone receptor 1 (TRH1) which has been found in a number of species including rat, mouse, and human and thyrotropin-releasing hormone receptor 2 (TRH2) which has, only been found in rodents. These TRH receptors are found in high levels in the anterior pituitary, and are also found in the retina and in certain areas of the brain.


Pssm-ID: 320126 [Multi-domain]  Cd Length: 269  Bit Score: 68.95  E-value: 3.71e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  46 TLSFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLT--IPVWVVSLVQHNQWPMGELTCKVTHLI 123
Cdd:cd14995   2 VATFLVLLICGVGIVGNIMVVLVVLRTRHMRTPTNCYLVSLAVADLMVLVAagLPNEIESLLGPDSWIYGYAGCLLITYL 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 124 FSINLFGSIFFLTCMSVDRYLSITY-----FTNTPSSRKKMVrrvvcILVWLLAFCVSLPDTYYLKTVTSASNNETYCRS 198
Cdd:cd14995  82 QYLGINASSLSITAFTIERYIAICHpmkaqFICTVSRAKKII-----CFVWIFTSLYCSPWLFLLDLSIKHYGDDIVVRC 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 199 FYpEHSIKEWLIgMELVSVVLGFAVPFSIIAVFYFLLARAISASSDQekhsSRKIIFSYVVVFLVCWLPYHVAVLLDIFS 278
Cdd:cd14995 157 GY-KVSRHYYLP-IYLADFVLFYVIPLLLAIVLYGLIGRILFSSRKQ----VTKMLAVVVVLFALLWMPYRTLVVYNSFA 230
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 31083344 279 ILHYIP----FTCRLehalftalhvtqCLSLvHCCVNPVLYSFINRNYR 323
Cdd:cd14995 231 SPPYLDlwflLFCRT------------CIYL-NSAINPILYNLMSQKFR 266
7tmA_Adenosine_R cd14968
adenosine receptor subfamily, member of the class A family of seven-transmembrane G ...
52-324 4.39e-13

adenosine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine receptors (or P1 receptors), a family of G protein-coupled purinergic receptors, bind adenosine as their endogenous ligand. There are four types of adenosine receptors in human, designated as A1, A2A, A2B, and A3. Each type is encoded by a different gene and has distinct functions with some overlap. For example, both A1 and A2A receptors are involved in regulating myocardial oxygen consumption and coronary blood flow in the heart, while the A2A receptor also has a broad spectrum of anti-inflammatory effects in the body. These two receptors also expressed in the brain, where they have important roles in the release of other neurotransmitters such as dopamine and glutamate, while the A2B and A3 receptors found primarily in the periphery and play important roles in inflammation and immune responses. The A1 and A3 receptors preferentially interact with G proteins of the G(i/o) family, thereby lowering the intracellular cAMP levels, whereas the A2A and A2B receptors interact with G proteins of the G(s) family, activating adenylate cyclase to elevate cAMP levels.


Pssm-ID: 341316 [Multi-domain]  Cd Length: 285  Bit Score: 68.82  E-value: 4.39e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  52 IFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWV-VLTIPVWVVSlvqHNQWPMGELTCKVTHLIFSINLFG 130
Cdd:cd14968   8 VLIAVLSVLGNVLVIWAVKLNRALRTVTNYFIVSLAVADILVgALAIPLAILI---SLGLPTNFHGCLFMACLVLVLTQS 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 131 SIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDT---YYLKTVTSASNNETYCRSFypehsikE 207
Cdd:cd14968  85 SIFSLLAIAIDRYLAIKIPLRYKSLVTGRRAWGAIAVCWVLSFLVGLTPMfgwNNGAPLESGCGEGGIQCLF-------E 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 208 WLIGMELVSVVLGFA---VPFSIIAVFYFLLARAIS------ASSDQEKHSSR---------KIIFSYVVVFLVCWLPYH 269
Cdd:cd14968 158 EVIPMDYMVYFNFFAcvlVPLLIMLVIYLRIFRVIRkqlrqiESLLRSRRSRStlqkevkaaKSLAIILFLFALCWLPLH 237
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 31083344 270 VAVLLDIFSILHYIPFTCrlehalftaLHVTQCLSLVHCCVNPVLYSFINRNYRY 324
Cdd:cd14968 238 IINCITLFCPECKVPKIL---------TYIAILLSHANSAVNPIVYAYRIRKFRQ 283
7tmA_5-HT7 cd15329
serotonin receptor subtype 7, member of the class A family of seven-transmembrane G ...
83-323 4.53e-13

serotonin receptor subtype 7, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT7 receptor, one of 14 mammalian serotonin receptors, is a member of the class A of GPCRs and is activated by the neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). 5-HT7 receptor mainly couples to Gs protein, which positively stimulates adenylate cyclase, leading to increased intracellular cAMP formation and calcium influx. 5-HT7 receptor is expressed in various human tissues, mainly in the brain, the lower gastrointestinal tract and in vital blood vessels including the coronary artery. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320452 [Multi-domain]  Cd Length: 260  Bit Score: 68.45  E-value: 4.53e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  83 ILNLAIADLWV-VLTIPVWVVSLVQhNQWPMGELTCKVTHLIFSINLFGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVR 161
Cdd:cd15329  39 IVSLAVSDLLVaLLVMPLAIIYELS-GYWPFGEILCDVWISFDVLLCTASILNLCAISVDRYLVITRPLTYAVKRTPKRM 117
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 162 RVVCILVWLLAFCVSLPDTYYLKtvtSASNNETYCrsFYPEHsikewlIGMELVSVVLGFAVPFSIIAVFYFLLARAisA 241
Cdd:cd15329 118 ALMIAIVWLLSALISIPPLFGWK---NKVNDPGVC--QVSQD------FGYQIYATFGAFYIPLIVMLVLYYKIYRA--A 184
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 242 SSDQEKHSSRKIIFSyvvVFLVCWLPYH-VAVLLDIFSILHYIPFTCRLEHalfTALHVTQCLSLvhccVNPVLYSFINR 320
Cdd:cd15329 185 KSERKAIKTLGIIMG---AFTLCWLPFFiLALLRPFLKPIKCSCIPLWLSR---LFLWLGYANSF----LNPIIYAKFNR 254

                ...
gi 31083344 321 NYR 323
Cdd:cd15329 255 EFR 257
7tmA_QRFPR cd15205
pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane ...
50-323 7.02e-13

pyroglutamylated RFamide peptide receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; 26RFa, also known as QRFP (Pyroglutamylated RFamide peptide), is a 26-amino acid residue peptide that belongs to a family of neuropeptides containing an Arg-Phe-NH2 (RFamide) motif at its C-terminus. 26Rfa/QRFP exerts similar orexigenic activity including the regulation of feeding behavior in mammals. It is the ligand for G-protein coupled receptor 103 (GPR103), which is predominantly expressed in paraventricular (PVN) and ventromedial (VMH) nuclei of the hypothalamus. GPR103 shares significant protein sequence homology with orexin receptors (OX1R and OX2R), which have recently shown to produce a neuroprotective effect in Alzheimer's disease by forming a functional heterodimer with GPR103.


Pssm-ID: 320333 [Multi-domain]  Cd Length: 298  Bit Score: 68.27  E-value: 7.02e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  50 IYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWV-VLTIPVWVVSLVQHNqWPMGELTCKVTHLIFSINL 128
Cdd:cd15205   6 TYVLIFVLALFGNSLVIYVVTRKRAMRTATNIFICSLALSDLLItFFCIPFTLLQNISSN-WLGGAFMCKMVPFVQSTAV 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 129 FGSIFFLTCMSVDRYLSITYftNTPSSRKKMVRRVVCIL--VWLLAFCVSLPDTYYLKTVTS----ASNNETYCRSFYPE 202
Cdd:cd15205  85 VTSILTMTCIAVERHQGIVH--PLKMKWQYTNRRAFTMLglVWIVSVIVGSPMLFVQQLEVKydflYEKRHVCCLERWYS 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 203 HSIKEwliGMELVSVVLGFAVPFSIIAVFYFLLA-------RAISASSDQEKH------SSRK------IIFSYVVVFLV 263
Cdd:cd15205 163 PTQQK---IYTTFILVILFLLPLTTMLFLYSRIGyelwikkRVGDASVLQTIHgiemskISRKkkravkMMVTVVLLFAV 239
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 31083344 264 CWLPYHVAVLLDIFSILH--YIPFTCRLEHAlftalhVTQCLSLVHCCVNPVLYSFINRNYR 323
Cdd:cd15205 240 CWAPFHVVHMMIEYSNLEnkYDGVTIKLIFA------IVQLIGFSNSFNNPIVYAFMNENFK 295
7tmA_NTSR2 cd15356
neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G ...
50-323 8.68e-13

neurotensin receptor subtype 2, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320478 [Multi-domain]  Cd Length: 285  Bit Score: 67.97  E-value: 8.68e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  50 IYIFIFVIGMIANSVVVWVNIQAKT---TGYDTHCYILNLAIADLWV-VLTIPVWVVSLVQ-HNQWPMGELTCKVTHLIF 124
Cdd:cd15356   6 VYALIWALGAAGNALTIHLVLKKRSlrgLQGTVHYHLVSLALSDLLIlLISVPIELYNFVWfHYPWVFGDLVCRGYYFVR 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 125 SINLFGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLP------DTYYLKTVTSASNNET-YCR 197
Cdd:cd15356  86 DICSYATVLNIASLSAERYLAICQPLRAKRLLSKRRTKWLLALIWASSLGFALPmafimgQKYELETADGEPEPSSrVCT 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 198 SFYPEHSIKEWLigmeLVSVVLGFAVPFSIIAVFYFLLARAISASSDQEkhsSRKIIFSYVVVFLVCWLPYHVAVLLdif 277
Cdd:cd15356 166 VLVSRATLKVFI----QVNAFVSFVLPLALIAFLNGVTVSHLRIQSLQH---SVQVLRAIVIAYVICWLPYHARRLM--- 235
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 31083344 278 siLHYIPFTCRLEhALFTALH----VTQCLSLVHCCVNPVLYSFINRNYR 323
Cdd:cd15356 236 --FCYVPDDAWTD-SLYNFYHyfymLTNTLFYVSSAVNPLLYNVVSSSFR 282
7tmA_Mel1A cd15402
melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
46-325 9.16e-13

melatonin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320524 [Multi-domain]  Cd Length: 279  Bit Score: 67.62  E-value: 9.16e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  46 TLSFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVTHLIFS 125
Cdd:cd15402   2 ALACILIFTIVVDILGNLLVILSVYRNKKLRNAGNIFVVSLAVADLVVAIYPYPLVLTSIFHNGWNLGYLHCQISGFLMG 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 126 INLFGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDtyyLKTVTSASNNETYCRSFypEHSI 205
Cdd:cd15402  82 LSVIGSIFNITGIAINRYCYICHSLKYDKLYSDKNSLCYVLLIWVLTVAAIVPN---LFVGSLQYDPRIYSCTF--AQSV 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 206 KEwliGMELVSVVLGFAVPFSIIAVFYF------LLARAISASSDQEK---HSSRKIIFSYV--VVFLVCWLPYH---VA 271
Cdd:cd15402 157 SS---AYTIAVVFFHFILPIIIVTFCYLriwilvIQVRRRVKPDNKPKlkpHDFRNFVTMFVvfVLFAVCWAPLNfigLA 233
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 31083344 272 VLLDIFSILHYIPftcrleHALFTALHVtqcLSLVHCCVNPVLYSFINRNYRYE 325
Cdd:cd15402 234 VAVDPETIVPRIP------EWLFVASYY---MAYFNSCLNAIIYGLLNQNFRRE 278
7tmA_tyramine_R-like cd15061
tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G ...
79-323 9.52e-13

tyramine receptors and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine-specific receptors and similar proteins found in insects and other invertebrates. These tyramine receptors form a distinct receptor family that is phylogenetically different from the other tyramine/octopamine receptors which also found in invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320189 [Multi-domain]  Cd Length: 256  Bit Score: 67.39  E-value: 9.52e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  79 THCYILNLAIADLWV-VLTIPVWVVSLVqHNQWPMGELTCKVtHLIFSINL-FGSIFFLTCMSVDRYLSITYFTNTPSSR 156
Cdd:cd15061  34 TNCYIVSLATADLLVgVLVLPLAIIRQL-LGYWPLGSHLCDF-WISLDVLLcTASILNLCCISLDRYFAITYPLKYRTKR 111
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 157 KKMVRRVVCILVWLLAFCVSLPDTYylktVTSASNNETYCRSFYPEHSikewliGMELVSVVLGFAVPFSIIAVFYFLLA 236
Cdd:cd15061 112 SRRLAITMILAVWVISLLITSPPLV----GPSWHGRRGLGSCYYTYDK------GYRIYSSMGSFFLPLLLMLFVYLRIF 181
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 237 RAIsassdqekHSSRKIIFSYVVV---FLVCWLPYHVAVLLDIFSilhyipfTCRLEHALFTALhvtQCLSLVHCCVNPV 313
Cdd:cd15061 182 RVI--------AKERKTAKTLAIVvgcFIVCWLPFFIMYLIEPFC-------DCQFSEALSTAF---TWLGYFNSVINPF 243
                       250
                ....*....|
gi 31083344 314 LYSFINRNYR 323
Cdd:cd15061 244 IYAFYNKDFR 253
7tmA_NTSR1 cd15355
neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G ...
50-323 1.33e-12

neurotensin receptor subtype 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320477 [Multi-domain]  Cd Length: 310  Bit Score: 67.56  E-value: 1.33e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  50 IYIFIFVIGMIANSVVVWVNIQAKTTGY---DTHCYILNLAIADLWV-VLTIPVWVVSLVQ-HNQWPMGELTCKVTHLIF 124
Cdd:cd15355   6 IYLALFVVGTVGNSITLYTLARKKSLQHlqsTVHYHLASLALSDLLIlLLAMPVELYNFIWvHHPWAFGDAACRGYYFLR 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 125 SINLFGSIFFLTCMSVDRYLSITYFTNTPS--SRKKMVRRVVCIlvWLLAFCVSLPDTYYLktvtsasnNETYCRSFYPE 202
Cdd:cd15355  86 DACTYATALNVASLSVERYLAICHPFKAKSlmSRSRTKKFISAI--WLASALLAIPMLFTM--------GEQNRSGTHPG 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 203 HSIKEWLIGMELVSVV------LGFAVPFSIIAVFYFLLAR---------------------------AISASSDQEKHS 249
Cdd:cd15355 156 GLICTPIVDTSTLKVViqvnafLSFLFPMLVISVLNTLIANqltvmvnqaeqenqvctiggqrtvlsvSMEPGRVQSLRH 235
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 31083344 250 SRKIIFSYVVVFLVCWLPYHVAVLLDIF-SILHYIPFTCRLEHALFTalhVTQCLSLVHCCVNPVLYSFINRNYR 323
Cdd:cd15355 236 GVLVLRAVVIAFVVCWLPYHVRRLMFCYvSDEQWTTFLYDFYHYFYM---LTNVLFYVSSAINPILYNLVSANFR 307
7tmA_5-HT1A_vertebrates cd15330
serotonin receptor subtype 1A from vertebrates, member of the class A family of ...
54-323 1.52e-12

serotonin receptor subtype 1A from vertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320453 [Multi-domain]  Cd Length: 260  Bit Score: 66.93  E-value: 1.52e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  54 IFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWV-VLTIPVWVVSLVQhNQWPMGELTCKVTHLIFSINLFGSI 132
Cdd:cd15330  10 LILCAIFGNACVVAAIALERSLQNVANYLIGSLAVTDLMVsVLVLPMAALYQVL-NKWTLGQVTCDLFIALDVLCCTSSI 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 133 FFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDTYYLKTVTSASNNETYCRSFYPEHSIkewligm 212
Cdd:cd15330  89 LHLCAIALDRYWAITDPIDYVNKRTPRRAAVLISLTWLIGFSISIPPMLGWRTPEDRSDPDACTISKDPGYTI------- 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 213 elVSVVLGFAVPFSIIAVFYFLLARAisASSDQEKHSSRKIIFSyvvVFLVCWLPYHVAVLldifsILHYIPFTCRLEHA 292
Cdd:cd15330 162 --YSTFGAFYIPLILMLVLYGRIFKA--AARERKTVKTLGIIMG---TFILCWLPFFIVAL-----VLPFCESTCHMPEL 229
                       250       260       270
                ....*....|....*....|....*....|.
gi 31083344 293 LFTalhVTQCLSLVHCCVNPVLYSFINRNYR 323
Cdd:cd15330 230 LGA---IINWLGYSNSLLNPIIYAYFNKDFQ 257
7tmA_FFAR cd14983
free fatty acid receptors, member of the class A family of seven-transmembrane G ...
50-271 1.55e-12

free fatty acid receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the free fatty acid receptors (FFARs) which bind free fatty acids (FFAs). They belong to the class A G-protein coupled receptors and are composed of three members, each encoded by a separate gene (FFAR1, FFAR2, and FFAR3). These genes and a fourth pseudogene, GPR42, are localized together on chromosome 19. FFAR1 is a receptor for medium- and long-chain FFAs, whereas FFAR2 and FFAR3 are receptors for short chain FFAs (SCFAs), which have different ligand affinities. FFAR1 directly mediates FFA stimulation of glucose-stimulated insulin secretion and also indirectly increases insulin secretion by enhancing the release of incretin. FFAR2 activation by SCFA suppresses adipose insulin signaling, which leads to the inhibition of fat accumulation in adipose tissue. FAAR3 is expressed in intestinal L cells, which produces glucagon-like peptide 1 (GLP-1) and peptide YY (PYY), suggesting that this receptor may be involved in energy homeostasis. FFARs are considered important components of the body's nutrient sensing mechanism, and therefore, these receptors are potential therapeutic targets for the treatment of metabolic disorders, such as type 2 diabetes and obesity.


Pssm-ID: 320114 [Multi-domain]  Cd Length: 278  Bit Score: 67.07  E-value: 1.55e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  50 IYIFIFVIGMIANSVVVWVNI-QAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVQhNQWPMGELTCKVTHLIFSINL 128
Cdd:cd14983   6 VYVLTILLGLPSNLLALYAFVnRARLRLTPNVIYMINLCLSDLVFILSLPIKIVEALS-SAWTLPAVLCPLYNLAHFSTL 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 129 FGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFC-------VSLPDTYylKTVTSASNNETYC-RSFY 200
Cdd:cd14983  85 YASTCFLTAISAGRYLGVAFPIKYQLYKKPLYSCLVCVAIWALVIFhvtlvfiLETSGGT--LDINTPVGNSSTCyENFT 162
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 31083344 201 PEHSIKEWLIGMELvSVVLgFAVPFSIIAVFYFLLARAISASS--DQEKHSSRKIIFSYVVVFLVCWLPYHVA 271
Cdd:cd14983 163 PEQLALLAPVRLEL-SLVL-FFLPLAITAFCYVRCIRILVRSRlhERRKRRAVRVAVSTLLTFVVCFGPYNIS 233
PHA03235 PHA03235
DNA packaging protein UL33; Provisional
34-322 1.84e-12

DNA packaging protein UL33; Provisional


Pssm-ID: 223017 [Multi-domain]  Cd Length: 409  Bit Score: 67.91  E-value: 1.84e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344   34 CPNMPNKSVLLYTLSFIYIFIFVIGMIANSVVVWVNIQA-KTTGYDTHC-YILNLAIADLWVVLTIPVWVVSlvqhNQWP 111
Cdd:PHA03235  22 CVPTEGLSAARTTETFINLLIISVGGPLNLIVLVTQLLAnRVHGFSTPTlYMTNLYLANLLTVFVLPFIMLS----NQGL 97
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  112 MGE--LTCKVTHLIFSINLFGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRrVVCILVWLLAFCVSLPDTYYLKTVTSA 189
Cdd:PHA03235  98 LSGsvAGCKFASLLYYASCTVGFATVALIAADRYRVIHQRTRARSSAYRSTY-KILGLTWFASLICSGPAPVYTTVVAHD 176
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  190 SNNET-----YCRSFYPEHSIKEWLIGME-LVSVVLGFAvPFSIIAVFYFLLARAISASSdqEKHSSRKIIFSYVVV--F 261
Cdd:PHA03235 177 DVDPEapgyeTCVIYFRADQVKTVLSTFKvLLTLVWGIA-PVVMMTWFYTFFYRTLKRAS--YKKRSRTLTFVCILLlsF 253
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 31083344  262 LVCWLPYHVAVLLDIFSILHYiPFTCRLEHALFTALHVTQCLSLVHCCVNPVLYSFINRNY 322
Cdd:PHA03235 254 LCLQTPFVAIMIFDSYATLIW-PSDCEHINLRDAVSTLSRLVPNLHCLLNPILYAFLGNDF 313
7tmA_CCK-BR cd15979
cholecystokinin receptor type B, member of the class A family of seven-transmembrane G ...
50-323 1.91e-12

cholecystokinin receptor type B, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320645 [Multi-domain]  Cd Length: 275  Bit Score: 66.76  E-value: 1.91e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  50 IYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWV-VLTIPVWVVSLVQHNqWPMGELTCKVTHLIFSINL 128
Cdd:cd15979   6 LYSVIFLLSVFGNMLIIVVLGLNKRLRTVTNSFLLSLALSDLMLaVFCMPFTLIPNLMGT-FIFGEVICKAVAYLMGVSV 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 129 FGSIFFLTCMSVDRYLSITyftNTPSSRKKMVRRVVCILV---WLLAFCVSLPDTYYLKTVTSASNNETY---CRSFYPE 202
Cdd:cd15979  85 SVSTFSLVAIAIERYSAIC---NPLQSRVWQTRSHAYRVIaatWLLSGLIMIPYPVYSVTVPVPVGDRPRghqCRHAWPS 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 203 HSIKE-WLIGMELVSvvlgFAVPFSIIAVFYFLLARAISASSDQEKHSSRKIIFsYVVVFLVCWLPYHVAvllDIFSILH 281
Cdd:cd15979 162 AQVRQaWYVLLLLIL----FFIPGVVMIVAYGLISRELYRGLLAKKRVIRMLVV-IVAMFFLCWLPIFSA---NTWRAFD 233
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 31083344 282 YIPFTCRLEHALFTALHVtqcLSLVHCCVNPVLYSFINRNYR 323
Cdd:cd15979 234 PLSAHRALSGAPISFIHL---LSYTSACVNPLVYCFMNRRFR 272
7tmA_NTSR cd15130
neurotensin receptors, member of the class A family of seven-transmembrane G protein-coupled ...
50-323 2.77e-12

neurotensin receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Neurotensin (NTS) is a 13 amino-acid neuropeptide that functions as both a neurotransmitter and a hormone in the nervous system and peripheral tissues, respectively. NTS exerts various biological activities through activation of the G protein-coupled neurotensin receptors, NTSR1 and NTSR2. In the brain, NTS is involved in the modulation of dopamine neurotransmission, opioid-independent analgesia, hypothermia, and the inhibition of food intake, while in the periphery NTS promotes the growth of various normal and cancer cells and acts as a paracrine and endocrine modulator of the digestive tract. The third neurotensin receptor, NTSR3 or also called sortilin, is not a G protein-coupled receptor.


Pssm-ID: 320258 [Multi-domain]  Cd Length: 281  Bit Score: 66.51  E-value: 2.77e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  50 IYIFIFVIGMIANSVVVWVNIQAKT---TGYDTHCYILNLAIADLWVVLT-IPVWVVSLVQ-HNQWPMGELTCKVTHLIF 124
Cdd:cd15130   6 IYLALFVVGTVGNSVTLFTLARKKSlqsLQSTVRYHLGSLALSDLLILLLaMPVELYNFIWvHHPWAFGDAGCRGYYFLR 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 125 SINLFGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPdTYYLKTVTSASNNETY-----CRSF 199
Cdd:cd15130  86 DACTYATALNVASLSVERYLAICHPFKAKTLMSRSRTKKFISAIWLASALLAIP-MLFTMGLQNESDDGTHpgglvCTPI 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 200 YPEHSIKEWLigmeLVSVVLGFAVPFSIIAVFYFLLARAISASSDQEKHSSRKIifsyVVVFLVCWLPYHVAVLLdifsi 279
Cdd:cd15130 165 VDTATLKVVI----QVNTFMSFLFPMLVTSILNTVIANKLVQALRRGVLVLRAV----VIAFVVCWLPYHVRRLM----- 231
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 31083344 280 LHYIP---FTCRLEHALFTALHVTQCLSLVHCCVNPVLYSFINRNYR 323
Cdd:cd15130 232 FCYISdeqWTTFLFDFYHYFYMLTNALFYVSSAINPILYNLVSANFR 278
7tmA_Mel1C cd15401
melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G ...
47-325 3.91e-12

melatonin receptor subtype 1C, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320523 [Multi-domain]  Cd Length: 279  Bit Score: 66.09  E-value: 3.91e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  47 LSFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVTHLIFSI 126
Cdd:cd15401   3 LAGVLIFTIVVDVLGNLLVILSVLRNKKLRNAGNIFVVSLSVADLVVAVYPYPLILLAIFHNGWTLGNIHCQISGFLMGL 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 127 NLFGSIFFLTCMSVDRYLSITYftNTPSSRKKMVRRVVCI--LVWLLAFCVSLPDTY-----YLKTVTSASNNETYCRSF 199
Cdd:cd15401  83 SVIGSVFNITAIAINRYCYICH--SLRYDKLYNMKKTCCYvcLTWVLTLAAIVPNFFvgslqYDPRIYSCTFAQTVSSSY 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 200 ypehsikewligmELVSVVLGFAVPFSIIAVFYF-LLARAISASSDQEKHSSRKI----------IFSYVVVFLVCWLPY 268
Cdd:cd15401 161 -------------TITVVVVHFIVPLSIVTFCYLrIWVLVIQVKHRVRQDSKQKLkandirnfltMFVVFVLFAVCWGPL 227
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 31083344 269 HVAVLLDIFSILHYIPftcRLEHALFTalhVTQCLSLVHCCVNPVLYSFINRNYRYE 325
Cdd:cd15401 228 NFIGLAVAINPLKVAP---KIPEWLFV---LSYFMAYFNSCLNAVIYGVLNQNFRKE 278
7tmA_ET-BR cd15976
endothelin B receptor, member of the class A family of seven-transmembrane G protein-coupled ...
45-323 3.97e-12

endothelin B receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Endothelins are able to activate a number of signal transduction processes including phospholipase A2, phospholipase C, and phospholipase D, as well as cytosolic protein kinase activation. They play an important role in the regulation of the cardiovascular system and are the most potent vasoconstrictors identified, stimulating cardiac contraction, regulating the release of vasoactive substances, and stimulating mitogenesis in blood vessels. Two endothelin receptor subtypes have been isolated and identified in vertebrates, endothelin A receptor (ET-A) and endothelin B receptor (ET-B), and are members of the seven transmembrane class A G-protein coupled receptor family which activate multiple effectors via different types of G protein. Some vertebrates contain a third subtype, endothelin A receptor (ET-C). ET-A receptors are mainly located on vascular smooth muscle cells, whereas ET-B receptors are present on endothelial cells lining the vessel wall. Endothelin receptors have also been found in the brain.


Pssm-ID: 320642 [Multi-domain]  Cd Length: 296  Bit Score: 66.03  E-value: 3.97e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  45 YTLSFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLW-VVLTIPVWVVSLVQHNqWPMGELTCKVTHLI 123
Cdd:cd15976   1 YINTVVSCLVFVLGIIGNSTLLRIIYKNKCMRNGPNILIASLALGDLLhIIIDIPINVYKLLAED-WPFGVEMCKLVPFI 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 124 FSINLFGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDTY------------YLKTVTSASN 191
Cdd:cd15976  80 QKASVGITVLSLCALSIDRYRAVASWSRIKGIGVPKWTAVEIVLIWVVSIILAVPEAIgfdmitmdykgeLLRICLLHPI 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 192 NETYCRSFYPEHsiKEWLIgmelvsVVLGFAVPFSIIAVFYFLL-----------ARAISASSDQEKHSSrKIIFSYVVV 260
Cdd:cd15976 160 QKTAFMQFYKTA--KDWWL------FSFYFCLPLACTAVFYTLMtcemlrkkngmQIALNDHLKQRREVA-KTVFCLVLV 230
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 31083344 261 FLVCWLPYHVAVLLDIFSILHYIPFTCRLEHALFTALHVTQCLSLVHCCVNPVLYSFINRNYR 323
Cdd:cd15976 231 FALCWLPLHLSRILKLTIYDEKDPNRCELLSFFLVLDYIGINMASLNSCINPIALYLVSKRFK 293
7tmA_GPR84-like cd15210
G protein-coupled receptor 84 and similar proteins, member of the class A family of ...
52-323 4.47e-12

G protein-coupled receptor 84 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR84, also known as the inflammation-related G-Protein coupled receptor EX33, is a receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Among these medium-chain FFAs, capric acid (C10:0), undecanoic acid (C11:0), and lauric acid (C12:0) are the most potent endogenous agonists of GPR84, whereas short-chain and long-chain saturated and unsaturated FFAs do not activate this receptor. GPR84 contains a [G/N]RY-motif instead of the highly conserved Asp-Arg-Tyr (DRY) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors and important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. In the case of GPR84, activation of the receptor couples to a pertussis toxin sensitive G(i/o)-protein pathway. GPR84 knockout mice showed increased Th2 cytokine production including IL-4, IL-5, and IL-13 compared to wild-type mice. It has been also shown that activation of GPR84 augments lipopolysaccharide-stimulated IL-8 production in polymorphonuclear leukocytes and TNF-alpha production in macrophages, suggesting that GPR84 may function as a proinflammatory receptor.


Pssm-ID: 320338 [Multi-domain]  Cd Length: 254  Bit Score: 65.36  E-value: 4.47e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  52 IFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVTHLIFSINLFGS 131
Cdd:cd15210   8 IVFMVVGVPGNLLTVLALLRSKKLRTRTNAFIINLSISDLLFCAFNLPLAASTFLHQAWIHGETLCRVFPLLRYGLVAVS 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 132 IFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPdTYYLKTVTSASNNETYCRSFYPE---HSIKEW 208
Cdd:cd15210  88 LLTLVLITLNRYILIAHPSLYPRIYTRRGLALMIAGTWIFSFGSFLP-LWLGIWGRFGLDPKVCSCSILRDkkgRSPKTF 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 209 LigmelvsVVLGFAVPFSIIAVFYFLlaraisassDQEKHSSRKIIFSYVVvFLVCWLPYHVAVLLDifsilhyipftcr 288
Cdd:cd15210 167 L-------FVFGFVLPCLVIIICYAR---------REDRRLTRMMLVIFLC-FLVCYLPITLVNVFD------------- 216
                       250       260       270
                ....*....|....*....|....*....|....*.
gi 31083344 289 lEHALFTALHV-TQCLSLVHCCVNPVLYSFINRNYR 323
Cdd:cd15210 217 -DEVAPPVLHIiAYVLIWLSSCINPIIYVAMNRQYR 251
7tmA_alpha2_AR cd15059
alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G ...
46-323 6.03e-12

alpha-2 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320187 [Multi-domain]  Cd Length: 261  Bit Score: 65.06  E-value: 6.03e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  46 TLSFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVtHLIFS 125
Cdd:cd15059   2 AISSIVSVVILLIIVGNVLVIVAVLTSRKLRAPQNWFLVSLAVADILVGLLIMPFSLVNELMGYWYFGSVWCEI-WLALD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 126 InLF--GSIFFLTCMSVDRYLSITYFTNTPSSRKKmvRRVVCIL--VWLLAFCVSLPDTYYLKTVTSASNNETYCrsfyp 201
Cdd:cd15059  81 V-LFctASIVNLCAISLDRYWSVTQAVEYNLKRTP--RRAKAMIaaVWIISAVISLPPLFGWKDEQPWHGAEPQC----- 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 202 EHSIKEWLIgmeLVSVVLGFAVPFSIIAVFYfllARAISASSDQEKHSSRkIIFSYVVVFLVCWLPYHVAVLLDIFSIlh 281
Cdd:cd15059 153 ELSDDPGYV---LFSSIGSFYIPLLIMIIVY---ARIYRAAKRKERRFTL-VLGVVMGAFVLCWLPFFFTYPLVVVCK-- 223
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 31083344 282 yipfTCRLEHALFTAlhvtqCLSLVHC--CVNPVLYSFINRNYR 323
Cdd:cd15059 224 ----TCGVPELLFKF-----FFWLGYCnsALNPVIYTIFNKDFR 258
7tmA_5-HT1_5_7 cd15064
serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G ...
42-330 6.66e-12

serotonin receptor subtypes 1, 5 and 7, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes serotonin receptor subtypes 1, 5, and 7 that are activated by the neurotransmitter serotonin. The 5-HT1 and 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family. The 5-HT1 receptor subfamily includes 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as 5-HT2C receptor. The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. The 5-HT7 receptor is coupled to Gs, which positively stimulates adenylate cyclase activity, leading to increased intracellular cAMP formation and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320192 [Multi-domain]  Cd Length: 258  Bit Score: 65.04  E-value: 6.66e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  42 VLLYTLSFIYIFIFvigmIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWV-VLTIPVWVVSLVQHnQWPMGELTCKVT 120
Cdd:cd15064   2 LISVLLSLIILATI----LGNALVIAAILLTRKLHTPANYLIASLAVADLLVaVLVMPLSAVYELTG-RWILGQVLCDIW 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 121 HLIFSINLFGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDTYYLKTVTSASNNEtyCRsfy 200
Cdd:cd15064  77 ISLDVTCCTASILHLCVIALDRYWAITDAVEYAHKRTPKRAAVMIALVWTLSICISLPPLFGWRTPDSEDPSE--CL--- 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 201 pehsIKEwLIGMELVSVVLGFAVPFSIIAVFYFLLARAisASSDQEKHSSRKIIfsyVVVFLVCWLPYHVAVLLDIFSIL 280
Cdd:cd15064 152 ----ISQ-DIGYTIFSTFGAFYIPLLLMLILYWKIYRA--AARERKAAKTLGII---LGAFIVCWLPFFLVALIVPLCSH 221
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 31083344 281 HYIPftcRLEHALFTALHVTQCLslvhccVNPVLYSFINRNYRyelmKAF 330
Cdd:cd15064 222 CWIP---LALKSFFLWLGYFNSL------INPLIYTFFNKDFR----KAF 258
7tmA_Melanopsin cd15336
vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G ...
45-274 7.38e-12

vertebrate melanopsins (Opsin-4), member of the class A family of seven-transmembrane G protein-coupled receptors; Melanopsin (also called Opsin-4) is the G protein-coupled photopigment that mediates non-visual responses to light. In mammals, these photoresponses include the photo-entrainment of circadian rhythm, pupillary constriction, and acute nocturnal melatonin suppression. Mammalian melanopsins are expressed only in the inner retina, whereas non-mammalian vertebrate melanopsins are localized in various extra-retinal tissues such as iris, brain, pineal gland, and skin. Melanopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320458 [Multi-domain]  Cd Length: 290  Bit Score: 65.12  E-value: 7.38e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  45 YTLSFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLT-IPVWVVSLVqHNQWPMGELTCKVthLI 123
Cdd:cd15336   1 YTVGSVILIIGITGMLGNALVIYAFCRSKKLRTPANYFIINLAVSDFLMSLTqSPIFFVNSL-HKRWIFGEKGCEL--YA 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 124 FSINLFG--SIFFLTCMSVDRYLSItyfTNTPSSRKKMVRRVVCI---LVWLLAFCVSLPDTYYLktvtSASNNE---TY 195
Cdd:cd15336  78 FCGALFGitSMITLLAISLDRYLVI---TKPLASIRWVSKKRAMIiilLVWLYSLAWSLPPLFGW----SAYVPEgllTS 150
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 196 CRSFYPEHSIKEWLIGMELVSVVlgFAVPFSIIAVFYFLLARAISASSDQ----------EKHSSR----------KIIF 255
Cdd:cd15336 151 CTWDYMTFTPSVRAYTMLLFCFV--FFIPLGIIIYCYLFIFLAIRSTGREvqklgsqdrkEKAKQYqrmknewkmaKIAF 228
                       250
                ....*....|....*....
gi 31083344 256 SYVVVFLVCWLPYHVAVLL 274
Cdd:cd15336 229 VVILLFVLSWSPYACVALI 247
7tmA_GnRHR_invertebrate cd15384
invertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
54-315 8.79e-12

invertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320506 [Multi-domain]  Cd Length: 293  Bit Score: 65.15  E-value: 8.79e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  54 IFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWV-VLTIP---VWVVSLvqhnQWPMGELTCKVTHLIFSINLF 129
Cdd:cd15384  10 MFVISFIGNLLTIIQIYRLRRSRRTIYSLLLHLAIADLLVtFFCIPseaIWAYTV----AWLAGNTMCKLVKYLQVFGLY 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 130 GSIFFLTCMSVDRYLSITYftntPSSRKKMVRRV--VCILVWLLAFCVSLPDTYYLKTVTSASNNETY-CRSFYpeHSIK 206
Cdd:cd15384  86 LSTYITVLISLDRCVAILY----PMKRNQAPERVrrMVTVAWILSPIFSIPQAVIFHVERGPFVEDFHqCVTYG--FYTA 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 207 EWLIGM-ELVSVVLGFAVPFSIIAVFYFLLARAISASSDQ---------------------EKHSSRKIIFSYVVVFLVC 264
Cdd:cd15384 160 EWQEQLyNMLSLVFMFPIPLVIMVTCYVLIFITLSKSSRDfqgleiytrnrgpnrqrlfhkAKVKSLRMSAVIVTAFILC 239
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 31083344 265 WLPYHVAVLLDIFsiLHYIPFTCRLEHALFTalhvtqcLSLVHCCVNPVLY 315
Cdd:cd15384 240 WTPYYVIMIWFLF--FNPYPLNDILFDVIFF-------FGMSNSCVNPLIY 281
7tmA_alpha1A_AR cd15325
alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
47-330 1.20e-11

alpha-1 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320448 [Multi-domain]  Cd Length: 261  Bit Score: 64.14  E-value: 1.20e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  47 LSFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVTHLIFSI 126
Cdd:cd15325   3 LGVILGGFILFGVLGNILVILSVACHRHLQTVTHYFIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDVL 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 127 NLFGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDTYYLKtvTSASNNETYCRsfypehsIK 206
Cdd:cd15325  83 CCTASIMSLCIISIDRYIGVSYPLRYPSIMTERRGLLALLCVWVLSLVISIGPLFGWK--EPAPEDETICQ-------IT 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 207 EwLIGMELVSVVLGFAVPFSIIAVFYFLLARAISASSDQEKhsSRKIIFSYVVVFLVCWLPYHVAVLLDIFsilhYIPFt 286
Cdd:cd15325 154 E-EPGYALFSALGSFYLPLAIILVMYCRVYVVALKFSREKK--AAKTLGIVVGCFVLCWLPFFLVMPIGSI----FPAY- 225
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 31083344 287 crleHALFTALHVTQCLSLVHCCVNPVLYSFINRNYRyelmKAF 330
Cdd:cd15325 226 ----KPSDTVFKITFWLGYFNSCINPIIYPCSSQEFK----KAF 261
7tmA_Opsin5_neuropsin cd15074
neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled ...
51-326 1.27e-11

neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropsin, also known as Opsin-5, is a photoreceptor protein expressed in the retina, brain, testes, and spinal cord. Neuropsin belongs to the type 2 opsin family of the class A G-protein coupled receptors. Mammalian neuropsin activates Gi protein-mediated photo-transduction pathway in a UV-dependent manner, whereas, in non-mammalian vertebrates, neuropsin is involved in regulating the photoperiodic control of seasonal reproduction in birds such as quail. As with other opsins, it may also act as a retinal photoisomerase.


Pssm-ID: 320202 [Multi-domain]  Cd Length: 284  Bit Score: 64.60  E-value: 1.27e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  51 YIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWV-VLTIPVWVVSLVQHnQWPMGELTCKV---THLIFSI 126
Cdd:cd15074   7 LTVIGILSTLGNGTVLFVLYRRRSKLKPAELLTVNLAVSDLGIsVFGYPLAIISAFAH-RWLFGDIGCVFygfCGFLFGC 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 127 nlfGSIFFLTCMSVDRYLSItyftNTPSSRKKMVRRVVCILV---WLLAFCVSLP-----DTYYLKTVTSASNNETYCRS 198
Cdd:cd15074  86 ---CSINTLTAISIYRYLKI----CHPPYGPKLSRRHVCIVIvaiWLYALFWAVAplvgwGSYGPEPFGTSCSIDWTGAS 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 199 FYPEHsiKEWLIGMelvsVVLGFAVPFSIIAVFYFLLARAISASSDQEKHSSR-------------KIIFSYVVVFLVCW 265
Cdd:cd15074 159 ASVGG--MSYIISI----FIFCYLLPVLIIVFSYVKIIRKVKSSRKRVAGFDSrskrqhkierkvtKVAVLICAGFLIAW 232
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 31083344 266 LPYHVAVLLDIFSILHYIPFTCRLEHALFTAlhvtqclslVHCCVNPVLYSFINRNYRYEL 326
Cdd:cd15074 233 TPYAVVSMWSAFGSPDSVPILASILPALFAK---------SSCMYNPIIYLLFSSKFRQDL 284
7tmA_NPY1R cd15395
neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G ...
45-326 1.38e-11

neuropeptide Y receptor type 1, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320517 [Multi-domain]  Cd Length: 293  Bit Score: 64.45  E-value: 1.38e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  45 YTLSFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWV-VLTIP-VWVVSLVQHnqWPMGELTCKVTHL 122
Cdd:cd15395   1 FTLALAYSAVIILGVSGNLALIIIILKQKEMHNVTNILIVNLSFSDLLMtIMCLPfTFVYTLMDH--WVFGEAMCKLNSM 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 123 IFSINLFGSIFFLTCMSVDRY-LSITYFTNTPSSRKKMVRRVVcilVWLLAFCVSLPDTYY-------LKTVTSASNNET 194
Cdd:cd15395  79 VQCISITVSIFSLVLIAIERHqLIINPRGWRPNNRHAYVGIAV---IWVLAVLTSLPFLIFqvltdepFKNVNVSLDAYK 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 195 ---YCRSFYPEHSIKewlIGMELVSVVLGFAVPFSIIAVFYFLLARAISASSD------QEKHSSRK------IIFSYVV 259
Cdd:cd15395 156 gkyVCLDQFPSDTIR---LSYTTCLLVLQYFGPLCFIFICYLKIYIRLKRRNNmmdkmrDNKYRSSEtkriniMLISIVV 232
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 31083344 260 VFLVCWLPYHVAVLldIFSILHYIPFTCRlEHALFTALHVTQCLSLvhcCVNPVLYSFINRNYRYEL 326
Cdd:cd15395 233 AFAVCWLPLNIFNA--VFDWNHEAIATCN-HNLLFLICHLTAMIST---CVNPIFYGFLNKNFQRDL 293
7tmA_BNGR-A34-like cd15000
putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of ...
48-323 1.77e-11

putative neuropeptide receptor BNGR-A34 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes putative neuropeptide receptor BNGR-A34 found in silkworm and its closely related proteins from invertebrates. They are members of the class A rhodopsin-like GPCRs, which represent a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320131 [Multi-domain]  Cd Length: 285  Bit Score: 63.98  E-value: 1.77e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  48 SFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVTHLIFSIN 127
Cdd:cd15000   3 SSMFLPVVLFGIFGNFVLLYILASNRSLRTPTNLLIGNMALADLLTLLVCPWMFLVHDFFQNYVLGSVGCKLEGFLEGSL 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 128 LFGSIFFLTCMSVDRYLSITYftnTPSSR-KKMVRRVVCILVWLLAFCVSLPDTYYLKTVTSASNN--ETYCRSFYPEHS 204
Cdd:cd15000  83 LLASVLALCAVSYDRLTAIVL---PSEARlTKRGAKIVIVITWIVGLLLALPLAIYRSYRERQWKNflETYCAENTQVLP 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 205 IKEWLIGMELVSVVLGFAVpFSIIAVFYFL--LARAISASSDQE----KHSSRKIIFSYVVVFLVCWLPYhvAVLLDIFS 278
Cdd:cd15000 160 IYWHVIITVLVWLPLGIML-ICYSAIFWKLdkYERRVLRREHPSvvryKKKAAKTLFIVLITFVVCRIPF--TALIFYRY 236
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 31083344 279 ILHYIPFTCRLEHALFTAL-HVTQCLSLVHCCVNPVLYSFINRNYR 323
Cdd:cd15000 237 KLVPNDNTQNSVSGSFHILwFASKYLMFLNAAVNPLIYGFTNENFR 282
7tmA_NPY4R cd15397
neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G ...
51-326 2.08e-11

neuropeptide Y receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety.


Pssm-ID: 320519 [Multi-domain]  Cd Length: 293  Bit Score: 63.99  E-value: 2.08e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  51 YIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWV-VLTIPVWVVSLVQhNQWPMGELTCKVTHLIFSINLF 129
Cdd:cd15397   7 YSLVMAVGLLGNICLICVIARQKEKTNVTNILIANLSFSDILVcLVCLPFTVVYTLM-DYWIFGEVLCKMTPFIQCMSVT 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 130 GSIFFLTCMSVDRYLSITYftntPSSRKKMVRR--VVCILVWLLAFCVSLPDTYYLKTVTSASNNETYCRSFYPEHSI-- 205
Cdd:cd15397  86 VSILSLVLIALERHQLIIN----PTGWKPSVSQayLAVVVIWMLACFISLPFLAFHILTDEPYKNLSHFFAPLADKAVct 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 206 KEWLIGMELVS-----VVLGFAVPFSIIAVFYFLLARAISASSD----------QEKHSSR--KIIFSYVVVFLVCWLPY 268
Cdd:cd15397 162 ESWPSEHHKLAyttwlLLFQYCLPLLFILVCYLRIYLRLRRRKDmlerrgeynrRAGHSKRinVMLVSLVAAFALCWLPL 241
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 31083344 269 HVavLLDIFSILHYIPFTCRlEHALFTALHVTQCLSLvhcCVNPVLYSFINRNYRYEL 326
Cdd:cd15397 242 NV--FNAIADWNHEAIPHCQ-HNLIFSLCHLAAMAST---CVNPIIYGFLNSNFKKEV 293
7tmA_GnRHR_vertebrate cd15383
vertebrate gonadotropin-releasing hormone receptors, member of the class A family of ...
83-326 2.12e-11

vertebrate gonadotropin-releasing hormone receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; GnRHR, also known as luteinizing hormone releasing hormone receptor (LHRHR), plays an central role in vertebrate reproductive function; its activation by binding to GnRH leads to the release of follicle stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland. GnRHR is expressed predominantly in the gonadotrope membrane of the anterior pituitary as well as found in numerous extrapituitary tissues including lymphocytes, breast, ovary, prostate, and cancer cell lines. There are at least two types of GnRH receptors, GnRHR1 and GnRHR2, which couple primarily to G proteins of the Gq/11 family. GnRHR is closely related to the adipokinetic hormone receptor (AKH), which binds to a lipid-mobilizing hormone that is involved in control of insect metabolism. They share a common ancestor and are members of the class A of the seven-transmembrane, G-protein coupled receptor (GPCR) superfamily.


Pssm-ID: 320505 [Multi-domain]  Cd Length: 295  Bit Score: 63.93  E-value: 2.12e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  83 ILNLAIADLWVVLTI----PVWVVSLvqhnQWPMGELTCKVTHLIFSINLFGSIFFLTCMSVDRYLSITYFTNTPSSRKK 158
Cdd:cd15383  40 ILHLAAADLLVTFVVmpldAAWNVTV----QWYAGDLACRLLMFLKLFAMYSSAFVTVVISLDRHAAILNPLAIGSARRR 115
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 159 mVRRVVCIlVWLLAFCVSLPDTYYLKTVT-SASNNETYC--RSFYPEHsIKEWLIGMelVSVVLGFAVPFSIIAVFYFLL 235
Cdd:cd15383 116 -NRIMLCA-AWGLSALLALPQLFLFHTVTaTPPVNFTQCatHGSFPAH-WQETLYNM--FTFFCLFLLPLLIMIFCYTRI 190
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 236 ---------ARAISASSDQEKHSSR-----------KIIFSYVVVFLVCWLPYHVAVLLDIFS---ILHYIPFTcrLEHA 292
Cdd:cd15383 191 lleisrrmkEKKDSAKNEVALRSSSdnipkarmrtlKMTIVIVSSFIVCWTPYYLLGLWYWFSpemLEQTVPES--LSHI 268
                       250       260       270
                ....*....|....*....|....*....|....
gi 31083344 293 LFTalhvtqcLSLVHCCVNPVLYSFINRNYRYEL 326
Cdd:cd15383 269 LFL-------FGLLNACLDPLIYGLFTISFRRGL 295
7tmA_NPFFR1 cd15981
neuropeptide FF receptor 1, member of the class A family of seven-transmembrane G ...
51-323 2.52e-11

neuropeptide FF receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Neuropeptide FF (NPFF) is a mammalian octapeptide that belongs to a family of neuropeptides containing an RF-amide motif at their C-terminus that have been implicated in a wide range of physiological functions in the brain including pain sensitivity, insulin release, food intake, memory, blood pressure, and opioid-induced tolerance and hyperalgesia. The effects of these peptides are mediated through neuropeptide FF1 and FF2 receptors (NPFF1-R and NPFF2-R) which are predominantly expressed in the brain. NPFF induces pro-nociceptive effects, mainly through the NPFF1-R, and anti-nociceptive effects, mainly through the NPFF2-R. NPFF has been shown to inhibit adenylate cyclase via the Gi protein coupled to NPFF1-R.


Pssm-ID: 320647 [Multi-domain]  Cd Length: 299  Bit Score: 63.69  E-value: 2.52e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  51 YIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWV-VLTIPVWVVSLVQhNQWPMGELTCKVTHLIFSINLF 129
Cdd:cd15981   7 YLFIFLLCMVGNGLVCFIVLKNRQMRTVTNMFILNLAVSDLLVgIFCMPTTLVDNLI-TGWPFDNAMCKMSGLVQGMSVS 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 130 GSIFFLTCMSVDRYLSITYftntPSSRKKMVRR--VVCILVWLLAFCVSLPDTYYLkTVTSASNN---ETYCRSfYPEHS 204
Cdd:cd15981  86 ASVFTLVAIAVERFRCIVH----PFRQKLTLRKaiVTIVIIWVLALIIMCPSAVTL-TVTREEHHfmvDDYNNS-YPLYS 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 205 I-KEWL-IGMELVSVVLGFA----VPFSIIAVFYFLLARAISASS-----------DQEKHSSRKIIFSYVVV-----FL 262
Cdd:cd15981 160 CwEAWPdTEMRKIYTTVLFShiylAPLTLIVIMYARIAFKLFKSSapirgsqgeeeEGRRVSKRKIKVINMLIivalfFT 239
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 31083344 263 VCWLPYHVAVLLDIFSILHyipfTCRLEHALFTALHVTQCLSLVHCCVNPVLYSFINRNYR 323
Cdd:cd15981 240 LSWLPLWTLMLLTDYGHLS----EDQLNLVTVYVFPFAHWLAFFNSSVNPIIYGYFNENFR 296
7tmA_Mel1 cd15209
melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled ...
47-325 3.10e-11

melatonin receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320337 [Multi-domain]  Cd Length: 279  Bit Score: 63.26  E-value: 3.10e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  47 LSFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVTHLIFSI 126
Cdd:cd15209   3 LACVLIVTIVVDVLGNLLVILSVLRNKKLRNAGNIFVVSLSVADLVVAIYPYPLILHAIFHNGWTLGQLHCQASGFIMGL 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 127 NLFGSIFFLTCMSVDRYlsiTYFTNTPSSRKKMVRRVVCI---LVWLLAFCVSLPDTY-----YLKTVTSASNNETYCRS 198
Cdd:cd15209  83 SVIGSIFNITAIAINRY---CYICHSLQYDRLYSLRNTCCylcLTWLLTVLAVLPNFFigslqYDPRIYSCTFAQTVSTV 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 199 FypehsikewligmELVSVVLGFAVPFSIIAVFYFLLARAISASSDQEKHSSRK-----------IIFSYVVVFLVCWLP 267
Cdd:cd15209 160 Y-------------TITVVVIHFLLPLLIVSFCYLRIWVLVLQVRQRVKPDQRPklkpadvrnflTMFVVFVLFAVCWAP 226
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 31083344 268 YHVAVLLDIFSILHYIPftcRLEHALFTALHVtqcLSLVHCCVNPVLYSFINRNYRYE 325
Cdd:cd15209 227 LNFIGLAVAINPKEMAP---KIPEWLFVASYF---MAYFNSCLNAIIYGLLNQNFRKE 278
7tmA_5-HT2_insect-like cd15307
serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane ...
79-328 3.74e-11

serotonin receptor subtype 2 from insects, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320433 [Multi-domain]  Cd Length: 279  Bit Score: 63.05  E-value: 3.74e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  79 THCYILNLAIADLWV-VLTIPVWVVSLVQhNQWPMGELTCKVTHLIFSINLFGSIFFLTCMSVDRYLSITYftNTPSSRK 157
Cdd:cd15307  35 TNYFLMSLAITDLMVaVLVMPLGILTLVK-GHFPLSSEHCLTWICLDVLFCTASIMHLCTISVDRYLSLRY--PMRFGRN 111
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 158 KMVRRVV--CILVWLLAFCVSLPDTYYLKTVTSASNNETYCRSFYPEHsikewligmELVSVVLGFAVPFSIIAVFYFLL 235
Cdd:cd15307 112 KTRRRVTlkIVFVWLLSIAMSLPLSLMYSKDHASVLVNGTCQIPDPVY---------KLVGSIVCFYIPLGVMLLTYCLT 182
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 236 ARAISASSDQEKHSSR------KIIFSYVVVFLVCWLPYHVAVLLdifsILHYIPFTCRLEHALFtalHVTQCLSLVHCC 309
Cdd:cd15307 183 VRLLARQRSRHGRIIRleqkatKVLGVVFFTFVILWSPFFVLNLL----PTVCAECEERISHWVF---DVVTWLGYASSM 255
                       250
                ....*....|....*....
gi 31083344 310 VNPVLYSFINRNYRYELMK 328
Cdd:cd15307 256 VNPIFYTIFNKVFRQAFKK 274
7tmA_GPR39 cd15135
G protein-coupled receptor 39, member of the class A family of seven-transmembrane G ...
46-323 4.25e-11

G protein-coupled receptor 39, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR39 is an orphan G protein-coupled receptor that belongs to the growth hormone secretagogue and neurotensin receptor subfamily. GPR39 is expressed in peripheral tissues such as pancreas, gut, gastrointestinal tract, liver, kidney as well as certain regions of the brain. The divalent metal ion Zn(2+) has been shown to be a ligand capable of activating GPR39. Thus, it has been suggested that GPR39 function as a G(q)-coupled Zn(2+)-sensing receptor which involved in the regulation of endocrine pancreatic function, body weight, gastrointestinal mobility, and cell death.


Pssm-ID: 320263 [Multi-domain]  Cd Length: 320  Bit Score: 63.28  E-value: 4.25e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  46 TLSFIYIFIFVIGMIANSVVVWVNIQAKTTGYD----THcYILNLAIADLWV-VLTIPVWVVSLVQHN-QWPMGELTCKV 119
Cdd:cd15135   2 TLTLLYSLILVAGILGNSATIKVTQVLQKKGYLqksvTD-HMVSLACSDLLVlLLGMPVELYSAIWDPfATPSGNIACKI 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 120 THLIFSINLFGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCiLVWLLAFCVSLPDTYYLKTVTSASNNETYCRSF 199
Cdd:cd15135  81 YNFLFEACSYATILNVATLSFERYIAICHPFKYKALSGSRVRLLIC-FVWLTSALVALPLLFAMGTEDPLEAFPSYRGTR 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 200 YPEHSIKEWLI---------GMELVSVVLGFAVPFSIIAVFYFL---LARAISASSDQ--------------------EK 247
Cdd:cd15135 160 HHCQDQKSNLTictslsskwTVFQASIFSAFVLYLLVLASVAFMcrrMMRALMGSKKGavavkgpggsvqllrkhesaEG 239
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 248 HSSRK--IIF--SYVVVFLVCWLPYHVAVLLDIFSILHyiPFTCRLEHALFTALHVTQCLSLVHCCVNPVLYSFINRNYR 323
Cdd:cd15135 240 KTARKqtILFlgLIVGTLAVCWMPNQIRRIMAAAKPKD--DWTRSYFRAYIILLPIADTFFYLSSVLNPLLYNLSSQQFR 317
7tmA_Mel1B cd15400
melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G ...
47-325 4.69e-11

melatonin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; Melatonin (N-acetyl-5-methoxytryptamine) is a naturally occurring sleep-promoting chemical found in vertebrates, invertebrates, bacteria, fungi, and plants. In mammals, melatonin is secreted by the pineal gland and is involved in regulation of circadian rhythms. Its production peaks during the nighttime, and is suppressed by light. Melatonin is shown to be synthesized in other organs and cells of many vertebrates, including the Harderian gland, leukocytes, skin, and the gastrointestinal (GI) tract, which contains several hundred times more melatonin than the pineal gland and is involved in the regulation of GI motility, inflammation, and sensation. Melatonin exerts its pleiotropic physiological effects through specific membrane receptors, named MT1A, MT1B, and MT1C, which belong to the class A rhodopsin-like G-protein coupled receptor family. MT1A and MT1B subtypes are present in mammals, whereas MT1C subtype has been found in amphibians and birds. The melatonin receptors couple to G proteins of the G(i/o) class, leading to the inhibition of adenylate cyclase.


Pssm-ID: 320522 [Multi-domain]  Cd Length: 279  Bit Score: 62.56  E-value: 4.69e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  47 LSFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVTHLIFSI 126
Cdd:cd15400   3 LSSVLIFTTVVDILGNLLVIISVFRNRKLRNSGNVFVVSLALADLVVALYPYPLVLVAIFHNGWALGEMHCKVSGFVMGL 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 127 NLFGSIFFLTCMSVDRYLSITY---FTNTPSSRKKMVrrVVCiLVWLLAFCVSLPDTY-----YLKTVTSASNNETYCRS 198
Cdd:cd15400  83 SVIGSIFNITGIAINRYCYICHsfaYDKLYSRWNTLL--YVC-LIWALTVVAIVPNFFvgsleYDPRIYSCTFVQTASSS 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 199 FypehsikewligmELVSVVLGFAVPFSIIAVFYFLL--------ARAISASSDQEKHSSRK---IIFSYVVVFLVCWLP 267
Cdd:cd15400 160 Y-------------TIAVVVIHFIVPITVVSFCYLRIwvlviqvrRKVKSESKPRLKPSDFRnflTMFVVFVIFAICWAP 226
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 31083344 268 YHVAVLLDIFSILHYIPftcRLEHALFTalhVTQCLSLVHCCVNPVLYSFINRNYRYE 325
Cdd:cd15400 227 LNLIGLAVAINPQEMAP---KVPEWLFV---VSYFMAYFNSCLNAIIYGLLNQNFRKE 278
7tmA_SREB-like cd15005
super conserved receptor expressed in brain and related proteins, member of the class A family ...
52-323 5.07e-11

super conserved receptor expressed in brain and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320134 [Multi-domain]  Cd Length: 329  Bit Score: 63.25  E-value: 5.07e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  52 IFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLT-IPVWVVSLVQHNQWPMGELTCKVTHLIFSINLFG 130
Cdd:cd15005   8 GLILCVSLAGNLLFSVLIVRDRSLHRAPYYFLLDLCLADGLRSLAcFPFVMASVRHGSGWIYGALSCKVIAFLAVLFCFH 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 131 SIFFLTCMSVDRYLSITYFTntpSSRKKMVR----RVVCIlVWLLAFCVSLPDTYYLKTVT-------------SASNNE 193
Cdd:cd15005  88 SAFTLFCIAVTRYMAIAHHR---FYAKRMTFwtclAVICM-AWTLSVAMAFPPVFDVGTYTfireedqctfehrSYKAND 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 194 T-----------------YCRSFYPEH-------------SIKEW------LIGMELVSVVLGFAVPFSIIAVFYFLLAR 237
Cdd:cd15005 164 TlgfmlvlavviaathlvYLKLLIFLRhhrkmkpaqlvpaISQNWtfhgpgATGQAAANWTAGFGRGPTPPTLLGIRQAF 243
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 238 AISASS-------DQEKHSSRkIIFSYVVVFLVCWLPYHVAVLLDIFSILHYIPftcrleHALFTAlhvTQCLSLVHCCV 310
Cdd:cd15005 244 HSGARRllvldefKMEKRLTR-MFYAITLLFLLLWSPYIVACYIRVFVRGYAVP------QGFLTA---AVWMTFAQAGV 313
                       330
                ....*....|...
gi 31083344 311 NPVLYSFINRNYR 323
Cdd:cd15005 314 NPIVCFFFNRELR 326
7tmA_CCK-AR cd15978
cholecystokinin receptor type A, member of the class A family of seven-transmembrane G ...
49-323 5.63e-11

cholecystokinin receptor type A, member of the class A family of seven-transmembrane G protein-coupled receptors; Cholecystokinin receptors (CCK-AR and CCK-BR) are a group of G-protein coupled receptors which bind the peptide hormones cholecystokinin (CCK) or gastrin. CCK, which facilitates digestion in the small intestine, and gastrin, a major regulator of gastric acid secretion, are highly similar peptides. Like gastrin, CCK is a naturally-occurring linear peptide that is synthesized as a preprohormone, then proteolytically cleaved to form a family of peptides with the common C-terminal sequence (Gly-Trp-Met-Asp-Phe-NH2), which is required for full biological activity. CCK-AR (type A, alimentary; also known as CCK1R) is found abundantly on pancreatic acinar cells and binds only sulfated CCK-peptides with very high affinity, whereas CCK-BR (type B, brain; also known as CCK2R), the predominant form in the brain and stomach, binds CCK or gastrin and discriminates poorly between sulfated and non-sulfated peptides. CCK is implicated in regulation of digestion, appetite control, and body weight, and is involved in neurogenesis via CCK-AR. There is some evidence to support that CCK and gastrin, via their receptors, are involved in promoting cancer development and progression, acting as growth and invasion factors.


Pssm-ID: 320644 [Multi-domain]  Cd Length: 278  Bit Score: 62.58  E-value: 5.63e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  49 FIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVL-TIPVWVVSLVQHNqWPMGELTCKVTHLIFSIN 127
Cdd:cd15978   5 LLYSLIFLLSVLGNSLIIAVLIRNKRMRTVTNIFLLSLAVSDLMLCLfCMPFTLIPNLLKD-FIFGSAVCKTATYFMGIS 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 128 LFGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDTYYLKTVT-SASNNET--YCRSFYPEHS 204
Cdd:cd15978  84 VSVSTFNLVAISLERYSAICKPLKSRVWQTKSHALKVIAATWCLSFTIMLPYPIYSNLVPfTRINNSTgnMCRLLWPNDV 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 205 IKE-WLIGMELVSvvlgFAVPFSIIAVFYFLLARAISASSD--QEKHSSRKIIFSYVVVFLVCWLPyhvavlldIFSILH 281
Cdd:cd15978 164 TQQsWYIFLLLIL----FLIPGIVMMTAYGLISLELYRGIKflMAKKRVIRMLIVIVILFFLCWTP--------IFSANA 231
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 31083344 282 YIPFTCRLEHALFTALHVT--QCLSLVHCCVNPVLYSFINRNYR 323
Cdd:cd15978 232 WRAFDTRSADRLLSGAPISfiHLLSYTSACVNPIIYCFMNKRFR 275
7tmA_NPY6R cd15396
neuropeptide Y receptor type 6, member of the class A family of seven-transmembrane G ...
45-326 7.05e-11

neuropeptide Y receptor type 6, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety.


Pssm-ID: 320518 [Multi-domain]  Cd Length: 293  Bit Score: 62.16  E-value: 7.05e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  45 YTLSFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWV-VLTIPVWVV-SLVQHnqWPMGELTCKVTHL 122
Cdd:cd15396   1 FLLIIAYSVVTIVGLFGNLCLITIIKKQKEEHNVTNILIANLSLSDVLVcVMCIPFTAVyTLMDH--WIFGETMCKLTSF 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 123 IFSINLFGSIFFLTCMSVDRYLSITyftnTPSSRKKMVRRVV--CILVWLLAFCVSLPDTYYLKTVTSASNNETYCRSFY 200
Cdd:cd15396  79 VQSVSVSVSIFSLVLIAIERYQLIV----NPRGWKPSASHAYwgIVLIWLFSLMISIPFLIFHQLTDEPFRNLSSHSDFY 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 201 PEHS--IKEWLIGMELVS-----VVLGFAVPFSIIAVFY---FLLARAISASSDQEKHSSRKI---------IFSYVVVF 261
Cdd:cd15396 155 KDKVvcIEAWPSETERLIfttslLVFQYFVPLGFIFICYlkiFVCLKKRNSKIDRMRENESRLsenkrintmLISIVVTF 234
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 31083344 262 LVCWLPYHVAVLldIFSILHYIPFTCRlEHALFTALHVtqcLSLVHCCVNPVLYSFINRNYRYEL 326
Cdd:cd15396 235 AACWLPLNIFNV--VFDWNHEVLMSCH-HNLVFTLCHL---VAMVSTCINPIFYGFLNKNFQKDL 293
7tmA_alpha1D_AR cd15327
alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
50-323 7.43e-11

alpha-1 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320450 [Multi-domain]  Cd Length: 261  Bit Score: 61.85  E-value: 7.43e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  50 IYIFIFVIGMIANSVVVWVNIQAKTTgydTHCYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVTHLIFSINLF 129
Cdd:cd15327   9 IFILMAIVGNILVILSVACNRHLQTV---TNYFIVNLAIADLLLSTTVLPFSATLEVLGFWAFGRVFCDIWAAVDVLCCT 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 130 GSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDTYYLKtvTSASNNETYCrsfypehSIKEwL 209
Cdd:cd15327  86 ASILSLCVISVDRYVGVKHSLKYPTIMTERKAGVILVLLWVSSMVISIGPLLGWK--EPPPPDESIC-------SITE-E 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 210 IGMELVSVVLGFAVPFSIIAVFYFLLARAISASSDQEKhsSRKIIFSYVVVFLVCWLPYhvavlldiFSILHYIPFTCRL 289
Cdd:cd15327 156 PGYALFSSLFSFYLPLMVILVMYFRVYVVALKFSREKK--AAKTLAIVVGVFILCWFPF--------FFVLPLGSFFPAL 225
                       250       260       270
                ....*....|....*....|....*....|....
gi 31083344 290 EHALfTALHVTQCLSLVHCCVNPVLYSFINRNYR 323
Cdd:cd15327 226 KPSE-MVFKVIFWLGYFNSCVNPIIYPCSSKEFK 258
7tmA_alpha1_AR cd15062
alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G ...
79-323 7.54e-11

alpha-1 adrenergic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320190 [Multi-domain]  Cd Length: 261  Bit Score: 61.74  E-value: 7.54e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  79 THCYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVTHLIFSINLFGSIFFLTCMSVDRYLSITYFTNTPSSRKK 158
Cdd:cd15062  35 THYFIVNLAVADLLLSFTVLPFSATLEVLGYWAFGRIFCDVWAAVDVLCCTASIMSLCVISVDRYIGVRYPLNYPTIVTA 114
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 159 MVRRVVCILVWLLAFCVSLPDTYYLKtvTSASNNETYCrsfypehSIKEwLIGMELVSVVLGFAVPFSIIAVFYFLLARA 238
Cdd:cd15062 115 RRATVALLIVWVLSLVISIGPLLGWK--EPAPADEQAC-------GVNE-EPGYVLFSSLGSFYLPLAIILVMYCRVYVV 184
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 239 ISASSDQEKhsSRKIIFSYVVVFLVCWLPYHVAVLLDIFSIlhyipfTCRLEHALFTalhVTQCLSLVHCCVNPVLYSFI 318
Cdd:cd15062 185 AFKFSREKK--AAKTLGIVVGAFVLCWFPFFVVLPLGSLFS------TLKPPEPVFK---VVFWLGYFNSCLNPIIYPCS 253

                ....*
gi 31083344 319 NRNYR 323
Cdd:cd15062 254 SREFK 258
7tmA_alpha2B_AR cd15321
alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
50-323 9.69e-11

alpha-2 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320444 [Multi-domain]  Cd Length: 268  Bit Score: 61.48  E-value: 9.69e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  50 IYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVTHLIFSINLF 129
Cdd:cd15321  12 AITFLILFTIFGNVLVIIAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSLANELMGYWYFRKTWCEIYLALDVLFCT 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 130 GSIFFLTCMSVDRYLSITYFTNTPSsrKKMVRRVVCIL--VWLLAFCVSLPDTYYLKTVTSASNNETYCrsfypEHSIKE 207
Cdd:cd15321  92 SSIVHLCAISLDRYWSVSRAIEYNS--KRTPRRIKCIIliVWLIAAVISLPPLIYKGKQKDEQGGLPQC-----KLNEEA 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 208 WLIgmeLVSVVLGFAVPFSIIAVFYFllaRAISASSDQEKHssrkiiFSYVV-----VFLVCWLPYHVAvlldiFSILHY 282
Cdd:cd15321 165 WYI---LSSSIGSFFAPCLIMILVYL---RIYLIAKNREKR------FTFVLavvigVFVLCWFPFFFS-----YSLGAI 227
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 31083344 283 IPFTCRLEHALFTALH-VTQCLSlvhcCVNPVLYSFINRNYR 323
Cdd:cd15321 228 CPELCKVPHSLFQFFFwIGYCNS----SLNPVIYTIFNQDFR 265
7tmA_5-HT2A cd15304
serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G ...
47-323 2.20e-10

serotonin receptor subtype 2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341345 [Multi-domain]  Cd Length: 267  Bit Score: 60.72  E-value: 2.20e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  47 LSFIYIFIFVIGMIAnsVVVWVNIQAKTTGyDTHCYILNLAIADLWV-VLTIPVWVVSLVQHNQWPMGELTCKVTHLIFS 125
Cdd:cd15304   6 LTVIVIILTIAGNIL--VIMAVSLEKKLQN-ATNYFLMSLAIADMLLgFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDV 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 126 INLFGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDTYYLKTVTSASNNETYCrSFYPEHSI 205
Cdd:cd15304  83 LFSTASIMHLCAISLDRYIAIRNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSC-LLADENFV 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 206 kewligmeLVSVVLGFAVPFSIIAVFYFLLARAISASSDQEKHSSrKIIFSYVVVFLVCWLPYHVAVLLDIFSilhyiPF 285
Cdd:cd15304 162 --------LIGSFVAFFIPLTIMVITYFLTIKSLQQSISNEQKAS-KVLGIVFFLFVVMWCPFFITNVMAVIC-----KE 227
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 31083344 286 TCRlEHALFTALHVTQCLSLVHCCVNPVLYSFINRNYR 323
Cdd:cd15304 228 SCN-EVVIGGLLNVFVWIGYLSSAVNPLVYTLFNKTYR 264
7tmA_Histamine_H4R cd15295
histamine receptor subtype H4R, member of the class A family of seven-transmembrane G ...
46-330 2.73e-10

histamine receptor subtype H4R, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtype H4R, a member of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320422 [Multi-domain]  Cd Length: 267  Bit Score: 60.22  E-value: 2.73e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  46 TLSFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWV-VLTIPVWVVSLVQhNQWPMGELTCKVTHLIF 124
Cdd:cd15295   2 VLLFLMSLLALVIVLGNALVIIAFVVDKNLRHRSNYFFLNLAISDFFVgAISIPLYIPYTLT-NRWDFGRGLCVFWLVID 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 125 SINLFGSIFFLTCMSVDRYLSIT---YFTNTPSSRKKMVRRVVCilVWLLAFCVSLPdtyYLKTVTSASNNETYCRSFYp 201
Cdd:cd15295  81 YLLCTASVYNIVLISYDRYQSVSnavSYRNQQTATLRIVTQMVA--VWVLAFLVHGP---AILVSDSWKTEDGECEPEF- 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 202 ehsIKEWLIGMelVSVVLGFAVPFSIIAVFYFLLARAI-SASSDQEKHSSRKIIfsyVVVFLVCWLPYhvavlldifsIL 280
Cdd:cd15295 155 ---FSNWYILA--ITSVLEFLVPVILVAYFNTQIYWSLwKRLRDRKLAKSLAII---LGTFAICWAPY----------SL 216
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 31083344 281 HYIPFTCRLEHALFTALHVTQCLSLVHCCVNPVLYSFINRNYRYELMKAF 330
Cdd:cd15295 217 FTIIRAACEKHRGSPWYNFAFWLQWFNSFINPFLYPLCHKRFRKAFLKIF 266
7tmA_mAChR cd15049
muscarinic acetylcholine receptor subfamily, member of the class A family of ...
42-323 2.88e-10

muscarinic acetylcholine receptor subfamily, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341322 [Multi-domain]  Cd Length: 262  Bit Score: 60.03  E-value: 2.88e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  42 VLLYTLSFIYIFIFVIGMIANSVVVWVNIQAKTTgydTHCYILNLAIADLWV-VLTIPVWVVSLVQhNQWPMGELTCKVT 120
Cdd:cd15049   1 VLICIATGSLSLVTVGGNILVILSFRVNRQLRTV---NNYFLLSLACADLIIgLVSMNLYTVYLVM-GYWPLGPLLCDLW 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 121 HLIFSINLFGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDTY---YLKTVTSASNNETYCR 197
Cdd:cd15049  77 LALDYVASNASVMNLLLISFDRYFSVTRPLTYRAKRTPKRAILMIALAWVISFVLWAPAILgwqYFVGERTVPDGQCYIQ 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 198 sFYPEHSIKewligmeLVSVVLGFAVPFSIIAVFYFLLARAISAssdqEKHSSRkIIFSYVVVFLVCWLPYHVAVLLDIF 277
Cdd:cd15049 157 -FLDDPAIT-------FGTAIAAFYLPVLVMTILYWRIYRETAR----ERKAAR-TLSAILLAFIITWTPYNILVLVSTF 223
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 31083344 278 SIlHYIPftcrlehalFTALHVTQCLSLVHCCVNPVLYSFINRNYR 323
Cdd:cd15049 224 CA-KCIP---------DTLWSFGYWLCYINSTINPFCYALCNKTFR 259
7tm_GPCRs cd14964
seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...
47-319 4.13e-10

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410628 [Multi-domain]  Cd Length: 267  Bit Score: 59.75  E-value: 4.13e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  47 LSFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVTHLIFSI 126
Cdd:cd14964   1 TTIILSLLTCLGLLGNLLVLLSLVRLRKRPRSTRLLLASLAACDLLASLVVLVLFFLLGLTEASSRPQALCYLIYLLWYG 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 127 NLFGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDTYYlKTVTSASNNETYCRSFYPEHSIK 206
Cdd:cd14964  81 ANLASIWTTLVLTYHRYFALCGPLKYTRLSSPGKTRVIILGCWGVSLLLSIPPLVG-KGAIPRYNTLTGSCYLICTTIYL 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 207 EWLIGMELVSVVLgFAVPFSIIAVFYFLLARAISASSDQEKHSSR-----KIIFSYVVVFLVCWLPYhvAVLLDIFSILH 281
Cdd:cd14964 160 TWGFLLVSFLLPL-VAFLVIFSRIVLRLRRRVRAIRSAASLNTDKnlkatKSLLILVITFLLCWLPF--SIVFILHALVA 236
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 31083344 282 YIPFTCRLEhaLFTALhvtqcLSLVHCCVNPVLYSFIN 319
Cdd:cd14964 237 AGQGLNLLS--ILANL-----LAVLASTLNPFIYCLGN 267
7tmA_5-HT2B cd15306
serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G ...
52-323 5.02e-10

serotonin receptor subtype 2B, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341347 [Multi-domain]  Cd Length: 277  Bit Score: 59.46  E-value: 5.02e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  52 IFIFVIGMIANSVVVWVNIQ-AKTTGYDTHCYILNLAIADLWV-VLTIPVWVVSLVQHNQWPMGELTCKVTHLIFSINLF 129
Cdd:cd15306   7 ILMVIIPTIGGNILVILAVSlEKKLQYATNYFLMSLAVADLLVgLFVMPIALLTILFEAMWPLPLVLCPIWLFLDVLFST 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 130 GSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDTyyLKTVTSASNNETYCRSFYPEHSIKEWL 209
Cdd:cd15306  87 ASIMHLCAISLDRYIAIKKPIQASQYNSRATAFIKITVVWLISIGIAIPVP--IKGIETDVDNPNNITCVLTKERFGDFI 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 210 IGMELVSvvlgFAVPFSIIAVFYFLLARAISASSDQEKHSSRKIIFSYVVVFLVCWLPYHvavlldIFSILHYIPFTCRl 289
Cdd:cd15306 165 LFGSLAA----FFTPLAIMIVTYFLTIHALRKQTITNEQRASKVLGIVFFLFLLMWCPFF------ITNITSVLCDSCN- 233
                       250       260       270
                ....*....|....*....|....*....|....
gi 31083344 290 EHALFTALHVTQCLSLVHCCVNPVLYSFINRNYR 323
Cdd:cd15306 234 QTTLQMLMEIFVWIGYVSSGVNPLVYTLFNKTFR 267
7tmA_alpha1B_AR cd15326
alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G ...
51-323 5.23e-10

alpha-1 adrenergic receptors subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-1 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that primarily mediate smooth muscle contraction: alpha-1A, alpha-1B, and alpha-1D. Activation of alpha-1 receptors by catecholamines such as norepinephrine and epinephrine couples to the G(q) protein, which then activates the phospholipase C pathway, leading to an increase in IP3 and calcium. Consequently, the elevation of intracellular calcium concentration leads to vasoconstriction in smooth muscle of blood vessels. In addition, activation of alpha-1 receptors by phenylpropanolamine (PPA) produces anorexia and may induce appetite suppression in rats.


Pssm-ID: 320449 [Multi-domain]  Cd Length: 261  Bit Score: 59.52  E-value: 5.23e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  51 YIFIFVIGMIANSVVVWVNIQAKTTgydTHCYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVTHLIFSINLFG 130
Cdd:cd15326  10 FILFAIVGNILVILSVVCNRHLRIP---TNYFIVNLAIADLLLSFTVLPFSATLEILGYWVFGRIFCDIWAAVDVLCCTA 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 131 SIFFLTCMSVDRYLSITYFTNTPS--SRKKMVrrVVCILVWLLAFCVSLPDTYYLKtvTSASNNETYCR----SFYPehs 204
Cdd:cd15326  87 SILSLCAISIDRYIGVRHSLQYPTivTRKRAI--LALLGVWVLSTVISIGPLLGWK--EPAPPDDKVCEiteePFYA--- 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 205 ikewligmeLVSVVLGFAVPFSIIAVFY---FLLARAISassdQEKHSSrKIIFSYVVVFLVCWLPYHVAVLLDIFSILH 281
Cdd:cd15326 160 ---------LFSSLGSFYIPLIVILVMYcrvYIVALKFS----REKKAA-KTLGIVVGMFILCWLPFFIALPLGSLFSHL 225
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 31083344 282 YIPFTcrLEHALFtalhvtqCLSLVHCCVNPVLYSFINRNYR 323
Cdd:cd15326 226 KPPET--LFKIIF-------WLGYFNSCLNPIIYPCSSKEFK 258
7tmA_NAGly_R_GPR18 cd15166
N-arachidonyl glycine receptor, GPR18, member of the class A family of seven-transmembrane G ...
51-270 5.51e-10

N-arachidonyl glycine receptor, GPR18, member of the class A family of seven-transmembrane G protein-coupled receptors; N-arachidonyl glycine (NAGly), an endogenous metabolite of the endocannabinoid anandamide, has been identified as an endogenous ligand of the G(i/o) protein-coupled receptor 18 (GPR18). NAGly is involved in directing microglial migration in the CNS through activation of GPR18. NAGly-GPR18 signaling is thought to play an important role in microglial-neuronal communication. Recent studies also show that GPR18 functions as the abnormal cannabidiol (Abn-CBD) receptor. Abn-CBD is a synthetic isomer of cannabidiol and is inactive at cannabinoid receptors (CB1 or CB2), but acts as a selective agonist at GPR18. The NAGly receptor is a member of the class A G protein-coupled receptor superfamily, which all have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, which then activate the heterotrimeric G proteins. G-proteins regulate a variety of cellular functions including metabolic enzymes, ion channels, and transporters, among many others.


Pssm-ID: 320294 [Multi-domain]  Cd Length: 275  Bit Score: 59.45  E-value: 5.51e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  51 YIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVQhNQWPMGELTCKVTHLIFSINLFG 130
Cdd:cd15166   7 YSFIFIIGLFVNITALWVFSCTTKKRTTVTVYMMNVALVDLIFILSLPFRMVYYAK-DEWPFGDYFCRILGALTVFYPSI 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 131 SIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDTYYLKTVTSASNNETyCRSFYPEHSIKEWLI 210
Cdd:cd15166  86 ALWLLAFISADRYMAIVQPKHAKELKNTPKAVLACVGVWIMTLASTFPLLFLYEDPDKASNFTT-CLKMLDIIHLKEVNV 164
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 31083344 211 gMELVSVVLGFAVPFSI-----IAVFYFLLARAISASSDQEKHSSRKIIFSYVVVFLVCWLPYHV 270
Cdd:cd15166 165 -LNFTRLIFFFLIPLFImigcyLVIIHNLVHGRTSKLKPKVKEKSIRIIITLIVQVLVCFVPFHI 228
7tmA_5-HT1F cd15334
serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G ...
62-323 1.10e-09

serotonin receptor subtype 1F, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320456 [Multi-domain]  Cd Length: 259  Bit Score: 58.42  E-value: 1.10e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  62 NSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVTHLIFSINLFGSIFFLTCMSVD 141
Cdd:cd15334  18 NSLVITAIIVTRKLHHPANYLICSLAVTDFLVAVLVMPFSIMYIVKETWIMGQVVCDIWLSVDITCCTCSILHLSAIALD 97
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 142 RYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDTYYLKTVTSASNnetycrsfypEHSIKEWLIGMELVSVVLGF 221
Cdd:cd15334  98 RYRAITDAVEYARKRTPKHAGIMIAVVWIISIFISMPPLFWRHQTTSRED----------ECIIKHDHIVFTIYSTFGAF 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 222 AVPFSIIAVFYFLLARAisASSDQEKHSSRKIIFSyvvVFLVCWLPYHVAVLldifsilhyIPFTCRLEHALFTALHVTQ 301
Cdd:cd15334 168 YIPLALILILYYKIYRA--ATRERKAATTLGLILG---AFVICWLPFFVKEV---------IVNTCDSCYISEEMSNFLT 233
                       250       260
                ....*....|....*....|..
gi 31083344 302 CLSLVHCCVNPVLYSFINRNYR 323
Cdd:cd15334 234 WLGYINSLINPLIYTIFNEDFK 255
7tmA_SWS2_opsin cd15077
short wave-sensitive 2 opsins, member of the class A family of seven-transmembrane G ...
45-323 1.37e-09

short wave-sensitive 2 opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Short Wave-Sensitive opsin 2 (SWS2), which mediates visual transduction in response to light at short wavelengths (violet to blue). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320205 [Multi-domain]  Cd Length: 280  Bit Score: 58.30  E-value: 1.37e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  45 YTLSFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVTHLIF 124
Cdd:cd15077   1 MGMSAFMLFLVIAGFPINVLTIICTIKYKKLRSHLNYILVNLAVANLIVVCFGSTTAFYSFSQMYFVLGPLACKIEGFTA 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 125 SINLFGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRrVVCILVWLLAFCVSLPDTY----YLK------------TVTS 188
Cdd:cd15077  81 TLGGMVSLWSLAVVAFERFLVICKPLGNFTFRGTHAI-IGCIATWVFGLAASLPPLFgwsrYIPeglqcscgpdwyTTNN 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 189 ASNNETYCrsfypehsikewligmeLVSVVLGFAVPFSIIAVFYFLLARAISASSDQEKHSSR---------KIIFSYVV 259
Cdd:cd15077 160 KWNNESYV-----------------MFLFCFCFGVPLSIIVFSYGRLLLTLRAVAKQQEQSAStqkaerevtKMVVVMVL 222
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 31083344 260 VFLVCWLPYHVAVLLDIFSilHYIPFTCRLEhalftalHVTQCLSLVHCCVNPVLYSFINRNYR 323
Cdd:cd15077 223 GFLVCWLPYASFALWVVTN--RGEPFDLRLA-------SIPSVFSKASTVYNPVIYVFMNKQFR 277
7tmA_GPR19 cd15008
G protein-coupled receptor 19, member of the class A family of seven-transmembrane G ...
46-323 1.48e-09

G protein-coupled receptor 19, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 19 is an orphan receptor that is expressed predominantly in neuronal cells during mouse embryogenesis. Its mRNA is found frequently over-expressed in patients with small cell lung cancer. GPR19 shares a significant amino acid sequence identity with the D2 dopamine and neuropeptide Y families of receptors. Human GPR19 gene, intronless in the coding region, also has a distribution in brain overlapping that of the D2 dopamine receptor gene, and is located on chromosome 12. GPR19 is a member of the class A family of GPCRs, which represents a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320137 [Multi-domain]  Cd Length: 275  Bit Score: 58.31  E-value: 1.48e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  46 TLSFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVTHLIFS 125
Cdd:cd15008   1 AASLVFGVLWLVSVFGNSLVCLVIHRSRRTQSTTNYFVVSMACADLLLSVASAPFVLLQFTSGRWTLGSAMCKLVRYFQY 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 126 INLFGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFcVSLPDTYYlktvtsaSNNETYCRSFYPEHSI 205
Cdd:cd15008  81 LTPGVQIYVLLSICVDRFYTIVYPLSFKVSREKAKKMIAASWLFDAAF-VSPALFFY-------GSNWGPHCNFFLPDSW 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 206 KEWLIGmeLVSVVLGFAVPFSIIAVFYFLLARAI-SASSD------------QEKHSSRKIIFSYVVVFLVCWLPYHVAV 272
Cdd:cd15008 153 DGAAYA--IIHLLVGFLVPSILIILFYQKVIKYIwRIGTDgrtvrrtmnivpRTKVKTIKMFLMLNSMFLLSWLPFYVVQ 230
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 31083344 273 LldifsilhYIPFTCRLEHALFTALHVTqCLSLVHCCVNPVLYSFINRNYR 323
Cdd:cd15008 231 L--------WHPRESDYRQSSLVFLAVT-WISFSSSASKPTLYSVYNANFR 272
7tmA_Histamine_H1R cd15050
histamine subtype H1 receptor, member of the class A family of seven-transmembrane G ...
53-323 1.49e-09

histamine subtype H1 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H1R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). H1R selectively interacts with the G(q)-type G protein that activates phospholipase C and the phosphatidylinositol pathway. Antihistamines, a widely used anti-allergy medication, act on the H1 subtype and produce drowsiness as a side effect. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320178 [Multi-domain]  Cd Length: 263  Bit Score: 58.21  E-value: 1.49e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  53 FIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWV-VLTIPVWVVSLVQHnQWPMGELTCKVTHLIFSINLFGS 131
Cdd:cd15050   9 TISLITVILNLLVLYAVRTERKLHTVGNLYIVSLSVADLIVgAVVMPLNIVYLLES-KWILGRPVCLFWLSMDYVASTAS 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 132 IFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDT--YYLKTVTSASNNETYCRSFYPEHSIkewl 209
Cdd:cd15050  88 IFSLFILCIDRYRSVQQPLKYLKYRTKTRASLMISGAWLLSFLWVIPILgwHHFARGGERVVLEDKCETDFHDVTW---- 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 210 igMELVSVVLGFAVPFSIIAVFYFLLARAIsassDQEKHSSRKIIFsYVVVFLVCWLPYHVavlldIFSILHYIPfTCRL 289
Cdd:cd15050 164 --FKVLTAILNFYIPSLLMLWFYAKIFKAV----NRERKAAKQLGF-IMAAFILCWIPYFI-----LFMVIAFCK-NCCN 230
                       250       260       270
                ....*....|....*....|....*....|....*
gi 31083344 290 EHalftaLH-VTQCLSLVHCCVNPVLYSFINRNYR 323
Cdd:cd15050 231 EN-----LHmFTIWLGYINSTLNPFIYPLCNENFK 260
7tmA_mAChR_M3 cd15299
muscarinic acetylcholine receptor subtype M3, member of the class A family of ...
42-323 1.79e-09

muscarinic acetylcholine receptor subtype M3, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. The M3 receptor is mainly located in smooth muscle, exocrine glands and vascular endothelium. It induces vomiting in the central nervous system and is a critical regulator of glucose homeostasis by modulating insulin secretion. Generally, M3 receptor causes contraction of smooth muscle resulting in vasoconstriction and increased glandular secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320426 [Multi-domain]  Cd Length: 274  Bit Score: 58.04  E-value: 1.79e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  42 VLLYTLSFIYIFIFVIGMIANSVVVWVNIQAKTTgydTHCYILNLAIADLWV-VLTIPVWVVSLVQhNQWPMGELTCKVT 120
Cdd:cd15299   4 VLIAFLTGILALVTIIGNILVIVSFKVNKQLKTV---NNYFLLSLACADLIIgVISMNLFTTYIIM-NRWALGNLACDLW 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 121 HLIFSINLFGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDTY---YLKTVTSASNNETYCR 197
Cdd:cd15299  80 LSIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAGVMIGLAWVISFVLWAPAILfwqYFVGKRTVPPDECFIQ 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 198 sFYPEHSIKewligmeLVSVVLGFAVPFSIIAVFYFLLARaisaSSDQEKHSSrKIIFSYVVVFLVCWLPYHVAVLLDIF 277
Cdd:cd15299 160 -FLSEPIIT-------FGTAIAAFYLPVTIMTILYWRIYK----ETIKEKKAA-QTLSAILLAFIITWTPYNIMVLVNTF 226
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 31083344 278 SiLHYIPftcrlehalFTALHVTQCLSLVHCCVNPVLYSFINRNYR 323
Cdd:cd15299 227 C-DSCIP---------KTYWNLGYWLCYINSTVNPVCYALCNKTFR 262
7tmA_TAAR1 cd15314
trace amine-associated receptor 1 and similar receptors, member of the class A family of ...
42-278 4.87e-09

trace amine-associated receptor 1 and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The trace amine-associated receptor 1 (TAAR1) is one of the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. TAAR1 is coupled to the Gs protein, which leads to activation of adenylate cyclase, and is thought to play functional role in the regulation of brain monoamines. TAAR1 is also shown to be activated by psychoactive compounds such as Ecstasy (MDMA), amphetamine and LSD. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320438 [Multi-domain]  Cd Length: 282  Bit Score: 56.48  E-value: 4.87e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  42 VLLYTLSFIYIFIFVIGmiaNSVVVWVNIQAKTTGYDTHCYILNLAIADLWV-VLTIPVWVVSLVQHNqWPMGELTCKVt 120
Cdd:cd15314   1 VLLYIFLGLISLVTVCG---NLLVIISIAHFKQLHTPTNYLILSLAVADLLVgGLVMPPSMVRSVETC-WYFGDLFCKI- 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 121 HLIFSINL-FGSIFFLTCMSVDRYLSI----TYftntpssRKKMVRRVVCILV---W----LLAFCVSLPDTYYLKTVTS 188
Cdd:cd15314  76 HSSFDITLcTASILNLCFISIDRYYAVcqplLY-------RSKITVRVVLVMIlisWsvsaLVGFGIIFLELNIKGIYYN 148
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 189 ASNNETYCRSFYPEHSikewligmELVSVVLGFAVPFSIIAVFY---FLLA----RAISASSDQEKHSSRK--------- 252
Cdd:cd15314 149 HVACEGGCLVFFSKVS--------SVVGSVFSFYIPAVIMLCIYlkiFLVAqrqaRSIQSARTKSGASSSKmerkatktl 220
                       250       260
                ....*....|....*....|....*..
gi 31083344 253 -IIFSyvvVFLVCWLPYHVAVLLDIFS 278
Cdd:cd15314 221 aIVMG---VFLLCWTPFFLCNIIDPFI 244
7tmA_mAChR_M2 cd15297
muscarinic acetylcholine receptor subtype M2, member of the class A family of ...
42-277 5.43e-09

muscarinic acetylcholine receptor subtype M2, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of M2 receptor causes a decrease in cAMP production, generally leading to inhibitory-type effects. This causes an outward current of potassium in the heart, resulting in a decreased heart rate. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320424 [Multi-domain]  Cd Length: 262  Bit Score: 56.51  E-value: 5.43e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  42 VLLYTLSFIYIFIFVIGMIANSVVVWVNIQAKTTgydTHCYILNLAIADLWV-VLTIPVWVVSLVQhNQWPMGELTCKVT 120
Cdd:cd15297   1 VFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTV---NNYFLFSLACADLIIgVFSMNLYTLYTVI-GYWPLGPVVCDLW 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 121 HLIFSINLFGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDTYYLKTVT---SASNNETYCR 197
Cdd:cd15297  77 LALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVggrTVPEGECYIQ 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 198 SFYPEhsikewliGMELVSVVLGFAVPFSIIAVFYFLLARAisasSDQEKHSSRKIIfSYVVVFLVCWLPYHVAVLLDIF 277
Cdd:cd15297 157 FFSNA--------AVTFGTAIAAFYLPVIIMTVLYWQISRA----SSREKKVTRTIL-AILLAFIITWTPYNVMVLINTF 223
7tmA_5-HT4 cd15056
serotonin receptor subtype 4, member of the class A family of seven-transmembrane G ...
46-323 5.54e-09

serotonin receptor subtype 4, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT4 subtype is a member of the serotonin receptor family that belongs to the class A G protein-coupled receptors, and binds the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the mammalian central nervous system (CNS). 5-HT4 receptors are selectively linked to G proteins of the G(s) family, which positively stimulate adenylate cyclase, causing cAMP formation and activation of protein kinase A. 5-HT4 receptor-specific agonists have been shown to enhance learning and memory in animal studies. Moreover, hippocampal 5-HT4 receptor expression has been reported to be inversely correlated with memory performance in humans. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320184 [Multi-domain]  Cd Length: 294  Bit Score: 56.73  E-value: 5.54e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  46 TLSFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWV-VLTIPVWVVSLVqHNQWPMGELTCKVTHLIF 124
Cdd:cd15056   2 VLSTFLSLVILLTILGNLLVIVAVCTDRQLRKKTNYFVVSLAVADLLVaVLVMPFGAIELV-NNRWIYGETFCLVRTSLD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 125 SINLFGSIFFLTCMSVDRYLSITyftntpssRKKMVRRVVCILVWL-LAFCVSLPDTYYLKTVTSASNNE----TYCRSF 199
Cdd:cd15056  81 VLLTTASIMHLCCIALDRYYAIC--------CQPLVYKMTPLRVAVmLGGCWVIPTFISFLPIMQGWNHIgiedLIAFNC 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 200 YPEHSIKEWLIGME--LVSVVLGFAVPFSIIAVFYF--------------LLARAISASSDQEKHSSRK----------- 252
Cdd:cd15056 153 ASGSTSCVFMVNKPfaIICSTVAFYIPALLMVLAYYriyvaareqahqirSLQRAGSSNHEADQHRNSRmrtetkaaktl 232
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 31083344 253 -IIFSyvvVFLVCWLPYHVAVLLDIFsILHYIPFTCrLEHALFtalhvtqcLSLVHCCVNPVLYSFINRNYR 323
Cdd:cd15056 233 gIIMG---CFCVCWAPFFVTNIVDPF-IGYRVPYLL-WTAFLW--------LGYINSGLNPFLYAFFNKSFR 291
7tmA_OXER1 cd15200
oxoeicosanoid receptor 1, member of the class A family of seven-transmembrane G ...
55-317 7.08e-09

oxoeicosanoid receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; OXER1, also called GPR170, is a receptor for eicosanoids and polyunsaturated fatty acids such as 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid (5-OXO-ETE), 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HPETE) and arachidonic acid. OXER1 is a member of the class A family of seven-transmembrane G-protein coupled receptors and appears to be coupled to the G(i/o) protein. The receptor is expressed in various tissues except brain. Phylogenetic analysis showed that GPR31 and OXER1 are the most closely related receptors to the hydroxycarboxylic acid receptor family (HCARs). OXER1, like GPR31, activates the ERK1/2 (MAPK3/MAPK1) pathway of intracellular signaling, but unlike GPR31, does cause increase in the cytosolic calcium level.


Pssm-ID: 320328 [Multi-domain]  Cd Length: 276  Bit Score: 56.32  E-value: 7.08e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  55 FVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVTHLIFSINLFGSIFF 134
Cdd:cd15200  11 FVLGLVGNGIALFIFCFHRRPWKSNTMYLLSLVVADFFLIINLPFRIDYYLRNEVWRFGATACQVNLFMLSMNRTASIVF 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 135 LTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPdtyyLKTVTSASNNETyCRSFYPEHSIK------EW 208
Cdd:cd15200  91 LTAIALNRYLKVVHPHHQLSKASVGCAAKVAAGLWILILLLNIH----LLLLDHVQSNST-CLSYDHGTDPSasdrwhRI 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 209 LIGMELVsVVLGFaVPFSIIAVFYFLLARAISASSDQEKhsSRKIIFSYVVVFLVCWLPyhvAVLLDIFSILHYIPFTCR 288
Cdd:cd15200 166 LFFLEFF-LPLGI-ILFCIFSIILTLKQRKLAKQAGPQR--AVKVLAVIVLVYTVCFLP---SILFALASLVAFKVSQCR 238
                       250       260
                ....*....|....*....|....*....
gi 31083344 289 LEHALFTALHVTQCLSLVHCCVNPVLYSF 317
Cdd:cd15200 239 SLDLCTQLFHGSLAFTYLNSALDPVLYCF 267
7tmA_D2_dopamine_R cd15309
D2 subtype of the D2-like family of dopamine receptors, member of the class A family of ...
45-323 7.33e-09

D2 subtype of the D2-like family of dopamine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320435 [Multi-domain]  Cd Length: 254  Bit Score: 55.81  E-value: 7.33e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  45 YTLSFIYIFIFVIgMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVTHLIF 124
Cdd:cd15309   2 YYAMLLTLLIFVI-VFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWRFSRIHCDIFVTLD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 125 SINLFGSIFFLTCMSVDRYLSIT--YFTNTPSSRKKMVRRVVCIlVWLLAFCVSLPDTYYLKtvtsaSNNETYCRSFYPE 202
Cdd:cd15309  81 VMMCTASILNLCAISIDRYTAVAmpMLYNTRYSSKRRVTVMISV-VWVLSFAISCPLLFGLN-----NTDQNECIIANPA 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 203 HSIkewligmelVSVVLGFAVPFSIIAVFYFLLARAIsassdQEKHSSRKIIFSYVVVFLVCWLPYHVAVLLDIFSilhy 282
Cdd:cd15309 155 FVV---------YSSIVSFYVPFIVTLLVYVQIYIVL-----QKEKKATQMLAIVLGVFIICWLPFFITHILNMHC---- 216
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 31083344 283 ipfTCRLEHALFTALhvtQCLSLVHCCVNPVLYSFINRNYR 323
Cdd:cd15309 217 ---DCNIPPALYSAF---TWLGYVNSAVNPIIYTTFNIEFR 251
7tmA_Octopamine_R cd15063
octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G ...
53-324 7.63e-09

octopamine receptors in invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor for octopamine (OA), which functions as a neurotransmitter, neurohormone, and neuromodulator in invertebrate nervous system. Octopamine (also known as beta, 4-dihydroxyphenethylamine) is an endogenous trace amine that is highly similar to norepinephrine, but lacks a hydroxyl group, and has effects on the adrenergic and dopaminergic nervous systems. Based on the pharmacological and signaling profiles, the octopamine receptors can be classified into at least two groups: OA1 receptors elevate intracellular calcium levels in muscle, whereas OA2 receptors activate adenylate cyclase and increase cAMP production.


Pssm-ID: 320191 [Multi-domain]  Cd Length: 266  Bit Score: 55.97  E-value: 7.63e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  53 FIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVTHLIFSINLFGSI 132
Cdd:cd15063   9 FLNVLVVLGNLLVIAAVLCSRKLRTVTNLFIVSLACADLLVGTLVLPFSAVNEVLDVWIFGHTWCQIWLAVDVWMCTASI 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 133 FFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDTYYLKTVTSASNNETYCRSFyPEHSIKEWLIGM 212
Cdd:cd15063  89 LNLCAISLDRYLAITRPIRYPSLMSTKRAKCLIAGVWVLSFVICFPPLVGWNDGKDGIMDYSGSSSL-PCTCELTNGRGY 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 213 ELVSVVLGFAVPFSIIAVFYFLLARAisASSDQEKHSSRKIIfsyVVVFLVCWLPYHVAVLLDIFSILHYIPFtcrleha 292
Cdd:cd15063 168 VIYSALGSFYIPMLVMLFFYFRIYRA--ARMETKAAKTVAII---VGCFIFCWLPFFTVYLVRAFCEDCIPPL------- 235
                       250       260       270
                ....*....|....*....|....*....|..
gi 31083344 293 LFTalhVTQCLSLVHCCVNPVLYSFINRNYRY 324
Cdd:cd15063 236 LFS---VFFWLGYCNSALNPCIYALFSRDFRF 264
7tmA_D4_dopamine_R cd15308
D4 dopamine receptor of the D2-like family, member of the class A family of ...
47-323 1.17e-08

D4 dopamine receptor of the D2-like family, member of the class A family of seven-transmembrane G protein-coupled receptors; Dopamine receptors are members of the class A G protein-coupled receptors that are involved in many neurological processes in the central nervous system (CNS). The neurotransmitter dopamine is the primary endogenous agonist for dopamine receptors. Dopamine receptors consist of at least five subtypes: D1, D2, D3, D4, and D5. The D1 and D5 subtypes are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4 subtypes are members of the D2-like family. Activation of D2-like family receptors is linked to G proteins of the G(i) family. This leads to a decrease in adenylate cyclase activity, thereby decreasing cAMP levels. Dopamine receptors are major therapeutic targets for neurological and psychiatric disorders such as drug abuse, depression, schizophrenia, or Parkinson's disease.


Pssm-ID: 320434 [Multi-domain]  Cd Length: 258  Bit Score: 55.23  E-value: 1.17e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  47 LSFIYIFIFVIGMIANSVVVWVNI-QAKTTGYDTHCYILNLAIADLWV-VLTIPVWVVSLVQHNQWPMGELTCKVTHLIF 124
Cdd:cd15308   2 AALVGGVLLILAIIAGNVLVCLSVcTERALKTTTNYFIVSLAVADLLLaLLVLPLYVYSEFQGGVWTLSPVLCDALMTMD 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 125 SINLFGSIFFLTCMSVDRYLSITYFTNTpSSRKKMVRRVVCI-LVWLLAFCVSLPDTYYLKTVtsASNNETYCRSFYPEH 203
Cdd:cd15308  82 VMLCTASIFNLCAISVDRFIAVSVPLNY-NRRQGSVRQLLLIsATWILSFAVASPVIFGLNNV--PNRDPAVCKLEDNNY 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 204 SIkewligmelVSVVLGFAVPFSIIAVFYFLLARAISassdqEKHSSRKIIFSYVVVFLVCWLPyhvavlldiFSILHYI 283
Cdd:cd15308 159 VV---------YSSVCSFFIPCPVMLVLYCAMFRGLG-----RERKAMRVLPVVVGAFLFCWTP---------FFVVHIT 215
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 31083344 284 PFTCRLEHALFTALHVTQCLSLVHCCVNPVLYSFINRNYR 323
Cdd:cd15308 216 RALCESCSIPPQLISIVTWLGYVNSALNPVIYTVFNAEFR 255
7tmA_5-HT2C cd15305
serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G ...
47-323 1.65e-08

serotonin receptor subtype 2C, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT2 receptors are a subfamily of serotonin receptors that bind the neurotransmitter serotonin (5HT; 5-hydroxytryptamine) in the central nervous system (CNS). The 5-HT2 subfamily is composed of three subtypes that mediate excitatory neurotransmission: 5-HT2A, 5-HT2B, and 5-HT2C. They are selectively linked to G proteins of the G(q/11) family and activate phospholipase C, which leads to activation of protein kinase C and calcium release. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in diseases such as migraine, schizophrenia, and depression. Indeed, 5-HT2 receptors are attractive targets for a variety of psychoactive drugs, ranging from atypical antipsychotic drugs, antidepressants, and anxiolytics, which have an antagonistic action on 5-HT2 receptors, to hallucinogens, which act as agonists at postsynaptic 5-HT2 receptors. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341346 [Multi-domain]  Cd Length: 275  Bit Score: 54.91  E-value: 1.65e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  47 LSFIYIFIFVIGmiANSVVVWVNIQAKTTGYDTHCYILNLAIADLWV-VLTIPVWVVSLVQHNQWPMGELTCKVTHLIFS 125
Cdd:cd15305   5 LLILIIIILTIG--GNILVIMAVSLEKKLQNATNFFLMSLAVADMLVgILVMPVSLIAILYDYAWPLPRYLCPIWISLDV 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 126 INLFGSIFFLTCMSVDRYLSITYFTNTP--SSRKKMVRRVVciLVWLLAFCVSLP--------DTYYLKTVTSASNNETY 195
Cdd:cd15305  83 LFSTASIMHLCAISLDRYVAIRNPIEHSrfNSRTKAMMKIA--AVWTISIGISMPipviglqdDEKVFVNGTCVLNDENF 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 196 CrsfypehsikewligmeLVSVVLGFAVPFSIIAVFYFLLARAI--SASSDQEKHSSrKIIFSYVVVFLVCWLPYHVAvl 273
Cdd:cd15305 161 V-----------------LIGSFVAFFIPLIIMVITYCLTIQVLqrQQAINNERRAS-KVLGIVFFLFLIMWCPFFIT-- 220
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 31083344 274 lDIFSILhyIPFTCRlEHALFTALHVTQCLSLVHCCVNPVLYSFINRNYR 323
Cdd:cd15305 221 -NILSVL--CKEACD-QKLMEELLNVFVWVGYVSSGINPLVYTLFNKTYR 266
7tmA_mAChR_M4 cd15298
muscarinic acetylcholine receptor subtype M4, member of the class A family of ...
42-323 2.09e-08

muscarinic acetylcholine receptor subtype M4, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to G(i/o) types of G proteins. The M4 receptor is mainly found in the CNS and function as an inhibitory autoreceptor regulating acetycholine release. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341344 [Multi-domain]  Cd Length: 262  Bit Score: 54.64  E-value: 2.09e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  42 VLLYTLSFIYIFIFVIGMIANSVVVWVNIQAKTTgydTHCYILNLAIADLWV-VLTIPVWVVSLVQhNQWPMGELTCKVT 120
Cdd:cd15298   1 VFIATVTGSLSLVTVVGNILVMLSIKVNRQLQTV---NNYFLFSLACADLIIgAFSMNLYTVYIIK-GYWPLGAVVCDLW 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 121 HLIFSINLFGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDTYYLKTVTSAsnnetycRSFY 200
Cdd:cd15298  77 LALDYVVSNASVMNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGK-------RTVP 149
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 201 PEHSIKEWLI--GMELVSVVLGFAVPFSIIAVFYFllarAISASSDQEKHSSRKIiFSYVVVFLVCWLPYHVAVLLDIFS 278
Cdd:cd15298 150 DNQCFIQFLSnpAVTFGTAIAAFYLPVVIMTVLYI----HISLASARERKVTRTI-FAILLAFILTWTPYNVMVLVNTFC 224
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 31083344 279 IlhyipfTCRLEhalfTALHVTQCLSLVHCCVNPVLYSFINRNYR 323
Cdd:cd15298 225 Q------SCIPD----TVWSIGYWLCYVNSTINPACYALCNATFK 259
7tmA_Histamine_H3R cd15296
histamine receptor subtypes H3R and H3R-like, member of the class A family of ...
42-323 2.10e-08

histamine receptor subtypes H3R and H3R-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine subtypes H3R and H3R-like, members of the histamine receptor family, which belong to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320423 [Multi-domain]  Cd Length: 271  Bit Score: 54.80  E-value: 2.10e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  42 VLLYTLSFIYIFIFVIGmiaNSVVVWVNIQAKTTGYDTHCYILNLAIADLWV-VLTIPVWVvSLVQHNQWPMGELTCKVT 120
Cdd:cd15296   1 VILAVLMALLVVATVLG---NALVILAFVVDSSLRTQGNFFFLNLAISDFLVgGFCIPLYI-PYVLTGRWKFGRGLCKLW 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 121 HLIFSINLFGSIFFLTCMSVDRYLSITYFTnTPSSRKKMVRRVV--CILVWLLAFCVSLPDTYYLKTVTSAS---NNETY 195
Cdd:cd15296  77 LVVDYLLCTASVFNIVLISYDRFLSVTRAV-SYRAQKGMTRQAVlkMVLVWVLAFLLYGPAIISWEYIAGGSiipEGECY 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 196 CRSFYpehsikEWLIGMelVSVVLGFAVPFsiIAVFYFLLA-------RAISASSDQEKHSSRKIIfsyVVVFLVCWLPY 268
Cdd:cd15296 156 AEFFY------NWYFLM--TASTLEFFTPF--ISVTYFNLSiylniqkRRFRLSRDKKVAKSLAII---VCVFGLCWAPY 222
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 31083344 269 hvavlldifSILHYIPFTCRLEHALFTALHVTQCLSLVHCCVNPVLYSFINRNYR 323
Cdd:cd15296 223 ---------TLLMIIRAACHGHCVPDYWYETSFWLLWVNSAINPVLYPLCHMSFR 268
7tmA_mAChR_M5 cd15300
muscarinic acetylcholine receptor subtype M5, member of the class A family of ...
42-323 2.52e-08

muscarinic acetylcholine receptor subtype M5, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. M5 mAChR is primarily found in the central nervous system and mediates acetylcholine-induced dilation of cerebral blood vessels. Activation of M5 receptor triggers a variety of cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides, and modulation of potassium channels. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320427 [Multi-domain]  Cd Length: 262  Bit Score: 54.26  E-value: 2.52e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  42 VLLYTLSFIYIFIFVIGMIANSVVVWVNIQAKTTgydTHCYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVTH 121
Cdd:cd15300   1 ITIAAVTAVVSLITIVGNVLVMISFKVNSQLKTV---NNYYLLSLACADLIIGIFSMNLYTSYILMGYWALGSLACDLWL 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 122 LIFSINLFGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDTY-YLKTVTSASNNETYCR-SF 199
Cdd:cd15300  78 ALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLISFILWAPPILcWQYFVGKRTVPERECQiQF 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 200 YPEHSIKewligmeLVSVVLGFAVPFSIIAVFYFLLARaisaSSDQEKHSSrKIIFSYVVVFLVCWLPYHVAVLLDIFSI 279
Cdd:cd15300 158 LSEPTIT-------FGTAIAAFYIPVSVMTILYCRIYK----ETIKERKAA-QTLSAILLAFIITWTPYNIMVLVSTFCS 225
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 31083344 280 lHYIPFTCrlehalftaLHVTQCLSLVHCCVNPVLYSFINRNYR 323
Cdd:cd15300 226 -DCIPLTL---------WHLGYWLCYVNSTVNPMCYALCNKTFR 259
7tmA_MrgprD cd15108
mas-related G protein-coupled receptor subtype D, member of the class A family of ...
47-326 3.02e-08

mas-related G protein-coupled receptor subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined.


Pssm-ID: 320236  Cd Length: 276  Bit Score: 54.38  E-value: 3.02e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  47 LSFIYIFIFVIGMIANSVVVW-VNIQAKTTGYDThcYILNLAIADLWVVLTIPVWVV--SLVQHNQWPMG-ELTCKVTHL 122
Cdd:cd15108   3 LSALVMFTCVCGMAGNGLVVWlLSCRGRRTPFCV--YVLHLAVADLLFLLCMASTLSleTSPLVITHDLAyEVVRRVKYF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 123 IFSInlfgSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDTYylktvtsasnnetYCRSFYPE 202
Cdd:cd15108  81 AYTA----SLSLLTAISTQRCLSVLFPIWYKCHQPRHLSAVVCALLWALSLLMNVLASF-------------FCSEFWHP 143
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 203 HSIKEWLIGMELVSVVLGFAVPfsIIAVFYFLLARAISASSDQEKHSSRK---IIFSYVVVFLVCWLPyhvavlLDIFSI 279
Cdd:cd15108 144 DEWQCFKVDMVFSFLIMGIFTP--VMALSSLILFVRVRRSSRQWRRRPTRlyvVVLASVLVFLACALP------LGIYWF 215
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 31083344 280 LHYIPFTCRLEHALFTalHVTQCLSLVHCCVNPVLYSFINRNYRYEL 326
Cdd:cd15108 216 LLYWLDLPQEVKTLFS--CLSRLSSSVSSSANPVIYFLVGSRGSRRL 260
7tmA_alpha2C_AR cd15323
alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G ...
47-323 3.20e-08

alpha-2 adrenergic receptors subtype C, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320446 [Multi-domain]  Cd Length: 261  Bit Score: 54.17  E-value: 3.20e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  47 LSFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVTHLIFSI 126
Cdd:cd15323   3 LAAVVGFLIVFTIVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMGYWYFGQVWCNIYLALDVL 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 127 NLFGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDtyyLKTVTSASNNETYCRSFYPEHSik 206
Cdd:cd15323  83 FCTSSIVHLCAISLDRYWSVTQAVEYNLKRTPRRVKAIIVTVWLISAVISFPP---LISMYRDPEGDVYPQCKLNDET-- 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 207 eWLIgmeLVSVVLGFAVPFSIIAVFYFLLARAISAssdqekhssRKIIFSYVV-----VFLVCWLPYHVAvlldiFSILH 281
Cdd:cd15323 158 -WYI---LSSCIGSFFAPCLIMILVYIRIYRVAKA---------REKRFTFVLavvmgVFVVCWFPFFFS-----YSLYG 219
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 31083344 282 YIPFTCRLEHALFTALHvtqCLSLVHCCVNPVLYSFINRNYR 323
Cdd:cd15323 220 ICREACEVPEPLFKFFF---WIGYCNSSLNPVIYTIFNQDFR 258
7tmA_tyramine_octopamine_R-like cd15060
tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G ...
45-323 4.27e-08

tyramine/octopamine receptor-like, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes tyramine/octopamine receptors and similar proteins found in insects and other invertebrates. Both octopamine and tyramine mediate their actions via G protein-coupled receptors (GPCRs) and are the invertebrate equivalent of vertebrate adrenergic neurotransmitters. In Drosophila, octopamine is involved in ovulation by mediating an egg release from the ovary, while a physiological role for tyramine in this process is not fully understood. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320188 [Multi-domain]  Cd Length: 260  Bit Score: 53.59  E-value: 4.27e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  45 YTLSFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWV-VLTIPVWVVSLVQhNQWPMGELTCKVTHLI 123
Cdd:cd15060   1 VVTTILLSVIIAFTIVGNILVILSVFTYRPLRIVQNFFIVSLAVADLAVaIFVLPLNVAYFLL-GKWLFGIHLCQMWLTC 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 124 FSINLFGSIFFLTCMSVDRYLSITYFTNTpsSRKKMVRRV--VCILVWLLAFCVSLPDTYYLKTVTSASNNETYCrSFYP 201
Cdd:cd15060  80 DILCCTASILNLCAIALDRYWAIHDPINY--AQKRTLKRVllMIVVVWALSALISVPPLIGWNDWPENFTETTPC-TLTE 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 202 EHsikewliGMELVSVVLGFAVPFSIIAVFYFLLARAISassdQEKHSSRkIIFSYVVVFLVCWLPYHVAVLLdifsilh 281
Cdd:cd15060 157 EK-------GYVIYSSSGSFFIPLLIMTIVYVKIFIATS----KERRAAR-TLGIIMGVFVVCWLPFFLMYVI------- 217
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 31083344 282 yIPF--TCRLEHALFTALhvtQCLSLVHCCVNPVLYSFINRNYR 323
Cdd:cd15060 218 -LPFceTCSPSAKVVNFI---TWLGYVNSALNPVIYTIFNLDFR 257
7tmA_Prostanoid_R cd14981
G protein-coupled receptors for prostanoids, member of the class A family of ...
52-278 9.88e-08

G protein-coupled receptors for prostanoids, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320112 [Multi-domain]  Cd Length: 288  Bit Score: 52.63  E-value: 9.88e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  52 IFIFVIGMIANSVVVWVNIQAKTTGYDTHCYIL--NLAIADLW-VVLTIPVWVVSLVQHNQWPMGELTCKVTHLIFSINL 128
Cdd:cd14981   8 ALMFVFGVLGNLLALIVLARSSKSHKWSVFYRLvaGLAITDLLgILLTSPVVLAVYASNFEWDGGQPLCDYFGFMMSFFG 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 129 FGSIFFLTCMSVDRYLSIT--YFTNTPSSRKKMvrRVVCILVWLLAFCV-SLPDTYYLKTVTSASNneTYCrsFYPEHSi 205
Cdd:cd14981  88 LSSLLIVCAMAVERFLAIThpFFYNSHVKKRRA--RLMLGAVWAFALLIaSLPLLGLGSYVLQYPG--TWC--FLDFYS- 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 206 KEWL------------IGMELVSVVLGFAVpfsIIAVFYFLLARAISASSDQEKHSSRKI-------IFSYVVVFLVCWL 266
Cdd:cd14981 161 KNTGdaayaylysilgLLILLVTLLCNLLV---IITLLRMRRRKKRHRRSRRSARRQKRNeiqmvvlLLAITVVFSVCWL 237
                       250
                ....*....|..
gi 31083344 267 PYHVAVLLDIFS 278
Cdd:cd14981 238 PLMIRVLINATG 249
7tmA_5-HT1E cd15335
serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G ...
47-323 1.06e-07

serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320457 [Multi-domain]  Cd Length: 258  Bit Score: 52.62  E-value: 1.06e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  47 LSFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWV-VLTIPVWVVSLVQhNQWPMGELTCKVTHLIFS 125
Cdd:cd15335   3 IVLTLALITILTTVLNSAVIAAICTTKKLHQPANYLICSLAVTDFLVaVLVMPLSITYIVM-DTWTLGYFICEIWLSVDM 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 126 INLFGSIFFLTCMSVDRYLSITyfTNTPSSRKKMVRR--VVCILVWLLAFCVSLPDTYYLKtvTSASNNETYCRsfypeh 203
Cdd:cd15335  82 TCCTCSILHLCVIALDRYWAIT--DAIEYARKRTAKRagLMILTVWTISIFISIPPLFWRN--HHDANIPSQCI------ 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 204 sIKEWLIGMELVSVVLGFAVPFSIIAVFYFllaRAISASSDQEKhsSRKIIFSYVVVFLVCWLPYHVAVLLDIFSIlhyi 283
Cdd:cd15335 152 -IQHDHVIYTIYSTFGAFYIPLTLILILYY---RIYHAASRERK--AARILGLILGAFILSWLPFFIKELIVGLSV---- 221
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 31083344 284 pFTCRLEHALFTALhvtqcLSLVHCCVNPVLYSFINRNYR 323
Cdd:cd15335 222 -MTVSPEVADFLTW-----LGYVNSLVNPLLYTSFNEDFK 255
7tmA_5-HT5 cd15328
serotonin receptor subtype 5, member of the class A family of seven-transmembrane G ...
42-322 1.34e-07

serotonin receptor subtype 5, member of the class A family of seven-transmembrane G protein-coupled receptors; 5-HT5 receptor, one of 14 mammalian 5-HT receptors, is activated by the neurotransmitter and peripheral signal mediator serotonin (also known as 5-hydroxytryptamine or 5-HT). The 5-HT5A and 5-HT5B receptors have been cloned from rat and mouse, but only the 5-HT5A isoform has been identified in human because of the presence of premature stop codons in the human 5-HT5B gene, which prevents a functional receptor from being expressed. 5-HT5 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/0) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320451 [Multi-domain]  Cd Length: 259  Bit Score: 52.26  E-value: 1.34e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  42 VLLYTLsfiYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVV-LTIPVWVVSLVQHNQWPMGELTCKVT 120
Cdd:cd15328   1 VLVLTL---LAMLVVATFLWNLLVLVTILRVRTFHRVPHNLVASMAVSDVLVAaLVMPLSLVHELSGRRWQLGRSLCQVW 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 121 HLIFSINLFGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDTYYLKTVTSASNNETYCRSFY 200
Cdd:cd15328  78 ISFDVLCCTASIWNVTAIALDRYWSITRHLEYTLRTRRRISNVMIALTWALSAVISLAPLLFGWGETYSEDSEECQVSQE 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 201 PEHSIkewligmelVSVVLGFAVPFSIIAVFYFLLARAIsassdQEKHSSRKIIFSYVVVFLVCWLPYHVAVLLDIFSIL 280
Cdd:cd15328 158 PSYTV---------FSTFGAFYLPLCVVLFVYWKIYKAA-----QKEKRAALMVGILIGVFVLCWIPFFLTELISPLCSC 223
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 31083344 281 HYIPftcrLEHALFTALHVTQCLslvhccVNPVLYSFINRNY 322
Cdd:cd15328 224 DIPP----IWKSIFLWLGYSNSF------FNPLIYTAFNKNY 255
7tmA_NPY5R cd15398
neuropeptide Y receptor type 5, member of the class A family of seven-transmembrane G ...
45-326 2.30e-07

neuropeptide Y receptor type 5, member of the class A family of seven-transmembrane G protein-coupled receptors; NPY is a 36-amino acid peptide neurotransmitter with a C-terminal tyrosine amide residue that is widely distributed in the brain and the autonomic nervous system of many mammalian species. NPY exerts its functions through five, G-protein coupled receptor subtypes including NPY1R, NPY2R, NPY4R, NPY5R, and NPY6R; however, NPY6R is not functional in humans. NYP receptors are also activated by its two other family members, peptide YY (PYY) and pancreatic polypeptide (PP). They typically couple to G(i) or G(o) proteins, which leads to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels, and are involved in diverse physiological roles including appetite regulation, circadian rhythm, and anxiety. When NPY signals through NPY2R in concert with NPY5R, it induces angiogenesis and consequently plays an important role in revascularization and wound healing. On the other hand, when NPY acts through NPY1R and NPYR5, it acts as a vascular mitogen, leading to restenosis and atherosclerosis.


Pssm-ID: 320520 [Multi-domain]  Cd Length: 273  Bit Score: 51.69  E-value: 2.30e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  45 YTLSFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVTHLIF 124
Cdd:cd15398   1 YFLIGLYTFISLLGFLGNLLILTALTKKWKQKTIINFLIGNLAFSDILVVLFCSPFTLTCVLLDQWIFGEVMCHIVPFLQ 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 125 SINLFGSIFFLTCMSVDRYLSITYftntPSSRKKMVRR--VVCILVWLLAFCVSLPDTYYLKTV-------TSASNNETY 195
Cdd:cd15398  81 CVSVMVSTLMLMSIAIVRYHMIKH----PLSNHLTANHgyFLLGTVWTLGFTICSPLPVFHKIVdlsetfnLESLKNKYL 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 196 CRSFYPEHSIKewlIGMELVSVVLGFAVPFSIIAVFYFLLARAISassdqekhSSRKIIFSY---VVVFLVCWLPYHVAV 272
Cdd:cd15398 157 CIESWPSDSYR---IAFTISLLFVQYILPLVCLTVSHTSVCRSVK--------RSRSVFYRLtivILAFAVSWMPLHLFH 225
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 31083344 273 LLDIFSILHyipFTCRLEHALFTALHVtqcLSLVHCCVNPVLYSFINRNYRYEL 326
Cdd:cd15398 226 LVTDFNANL---ISNRHFKLVYCICHL---LGMLSCCLNPILYGFLNNGIKSDL 273
7tmA_FFAR1 cd15169
free fatty acid receptor 1, member of the class A family of seven-transmembrane G ...
47-271 2.38e-07

free fatty acid receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the mammalian free fatty acid receptor 1 (FFAR1), also called GPR40. FFAR1 is a cell-surface receptor for medium- and long-chain free fatty acids (FFAs). The receptor is most potently activated by eicosatrienoic acid (C20:3), but can also be activated at micromolar concentrations of various fatty acids. FFAR1 directly mediates FFA stimulation of glucose-stimulated insulin secretion and indirectly increases insulin secretion by enhancing the release of incretin. Free fatty acid receptors (FFARs) belong to the class A G-protein coupled receptors and are comprised of three members, each encoded by a separate gene (FFAR1, FFAR2, and FFAR3). These genes and a fourth pseudogene, GPR42, are localized together on chromosome 19. FFARs are considered important components of the body's nutrient sensing mechanism, and therefore, these receptors are potential therapeutic targets for the treatment of metabolic disorders, such as type 2 diabetes and obesity.


Pssm-ID: 320297  Cd Length: 284  Bit Score: 51.55  E-value: 2.38e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  47 LSF-IYIFIFVIGMIANSVVV-WVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVTHLIF 124
Cdd:cd15169   2 LSFgLYVAAFALGFPLNVLAIrGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAH 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 125 SINLFGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFC-------VSLPDTYYLKTVTSAS-----NN 192
Cdd:cd15169  82 FAPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLChlglvfgLEAPGGWLDHSNTSLGintpvNG 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 193 ETYCRSFYPEHSIKEWLIGMELvsvvLGFAVPFSIIAVFYFLLARAISASSDQEKhssRKIIFSYV-----VVFLVCWLP 267
Cdd:cd15169 162 SPVCLEAWDPASAGPARFSLSL----LLFFLPLAITAFCYVGCLRALARSGLTHR---RKLRAAWVaggalLTLLLCVGP 234

                ....
gi 31083344 268 YHVA 271
Cdd:cd15169 235 YNAS 238
7tmA_GPR101 cd15215
orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G ...
82-326 2.60e-07

orphan G protein-coupled receptor 101, member of the class A family of seven-transmembrane G protein-coupled receptors; Gpr101, an orphan GPCR, is predominantly expressed in the brain within discrete nuclei and is predicted to couple to the stimulatory G(s) protein, a potent activator of adenylate cyclase. GPR101 has been implicated in mediating the actions of GnRH-(1-5), a pentapeptide formed by metallopeptidase cleavage of the decapeptide gonadotropin-releasing hormone (GnRH), which plays a critical role in the regulation of the hypothalamic-pituitary-gonadal axis. GnRH-(1-5) acts on GPR101 to stimulate epidermal growth factor (EFG) release and EFG-receptor (EGFR) phosphorylation, leading to enhanced cell migration and invasion in the Ishikawa endometrial cancer cell line. Furthermore, these effects of GnRH-(1-5) are also dependent on enzymatic activation of matrix metallopeptidase-9 (MMP-9). GPR101 is a member of the class A family of GPCRs, which includes receptors for hormones, neurotransmitters, sensory stimuli, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320343 [Multi-domain]  Cd Length: 261  Bit Score: 51.38  E-value: 2.60e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  82 YILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVTHLIFSINLFGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVR 161
Cdd:cd15215  37 FIFNLLVADLLQTVLVMPWVIATSVPLFWPLDSHLCTALVVLMHLFAFAGVNTIVVVSVDRYLAIIHPLSYPTKMTPRRG 116
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 162 RVVCILVWLLAFCVSLPDTYYLKTVTSASNNEtYCRSFYPEHSikewliGMELVSVVLGFAVPFSIIAVFYFLLARaisA 241
Cdd:cd15215 117 YLLIYGTWIVSVLQSTPPLYGWGQAAFDERNA-LCSVIWGSSY------SYTILSVVSSFVLPVIIMLACYSMVFR---A 186
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 242 SSDQEKHSSRKIIFSYVVVFLVCWLPYHVAVLLDIFSILHYIPFTCRLEHALFtalhvtqclsLVHCCVNPVLYSFINRN 321
Cdd:cd15215 187 ARRCYHCKAAKVIFIIIFSYVLSMGPYSFLSVLAVWVDTQVPQWVISIILWLF----------FLQCCIHPYIYGYMHKS 256

                ....*
gi 31083344 322 YRYEL 326
Cdd:cd15215 257 IKKEF 261
7tmA_MrgprH cd15110
mas-related G protein-coupled receptor subtype H, member of the class A family of ...
46-320 3.15e-07

mas-related G protein-coupled receptor subtype H, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined.


Pssm-ID: 320238  Cd Length: 274  Bit Score: 51.25  E-value: 3.15e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  46 TLSFIYIFIFVIGMIANSVVVWVNIQAKTTGYDThCYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVTHLIFs 125
Cdd:cd15110   2 IEVWVSLIICLLGLVGNGIVLWFLGFRIRRNPFT-VYILHLAIADFTFLLCIFILSIMYIGPFNFSHSRDYVAMLIFII- 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 126 INLFG---SIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDtyYLKTVTSASNNETYCRSFYpe 202
Cdd:cd15110  80 LFLFGyntGLYLLTAISVERCLSVLYPIWYRCHRPKHQSAIVCGLLWALSVLMTSLE--YLMCIDEGFHVRNECRAVL-- 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 203 hsikewligmeLVSVVLGFAVPFSIIAVFYFLLARAISASSdQEKHSSR--KIIFSYVVVFLVCWLPYHVAVLLDIFSil 280
Cdd:cd15110 156 -----------IFIGILTFLVFTPLMLISSLILFIKVRCNS-QRRHPGKlyIIIMLTVIFFLIFAMPMRVLLLLNYLH-- 221
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 31083344 281 hyipftcrlEHALFTALHVTQCLSLVHCCVNPVLYSFINR 320
Cdd:cd15110 222 ---------HSSFLFSNPVPFLLSTVNSSINPIVYFLVGS 252
7tmA_Glycoprotein_LRR_R-like cd14980
glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, ...
52-324 3.51e-07

glycoprotein hormone receptors and leucine-rich repeats containing G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes the glycoprotein hormone receptors (GPHRs), vertebrate receptors containing 17 leucine-rich repeats (LGR4-6), and the relaxin family peptide receptors (also known as LGR7 and LGR8). They are seven transmembrane domain receptors with a very large extracellular N-terminal domain containing many leucine-rich repeats responsible for hormone recognition and binding. The glycoprotein hormone receptor family contains receptors for the pituitary hormones, thyrotropin (thyroid-stimulating hormone receptor), follitropin (follicle-stimulating hormone receptor), and lutropin (luteinizing hormone receptor). Glycoprotein hormone receptors couple primarily to the G(s)-protein and promotes cAMP production, but also to the G(i)- or G(q)-protein. Two orphan GPCRs, LGR7 and LGR8, have been recently identified as receptors for the relaxin peptide hormones.


Pssm-ID: 320111 [Multi-domain]  Cd Length: 286  Bit Score: 51.09  E-value: 3.51e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  52 IFIFVIG---MIANSVVVWVNIQAKTTGYDTHCY-ILNLAIADL-----WVVLTIP--VWVVSLVQHNQWPMGELTCKVT 120
Cdd:cd14980   5 IFIWIIGilaLIGNILVIIWHISSKKKKKKVPKLlIINLAIADFlmgiyLLIIAIAdqYYRGRYAQYSEEWLRSPPCLLA 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 121 HLIFSINLFGSIFFLTCMSVDRYLSITY-FTNTPSSRKKMvrRVVCILVWLLAF-CVSLPdtyylktvTSASNNETYCRS 198
Cdd:cd14980  85 CFLVSLSSLMSVLMMLLITLDRYICIVYpFSNKRLSYKSA--KIILILGWLFSIiFAAIP--------ILYSINQPGDNR 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 199 FY-------PEHSIKEWLIGMELVSVVLGFAVpFSIIAVFYFLLARAISASSDQEKHSSRKI-------IFSYVVVFLVC 264
Cdd:cd14980 155 LYgyssicmPSNVSNPYYRGWLIAYLLLTFIA-WIIICILYILIFISVRKSRKSARRSSSKRdkriairLALILITDLIC 233
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 31083344 265 WLPYHVAVLLdifsilhyipFTCRLEHALFTALHVTQCLSL-VHCCVNPVLYSFINRNYRY 324
Cdd:cd14980 234 WLPYYIVIFS----------GLLTSTEIDIHVLQFIAILALpLNSAINPYLYTLTTPTFKR 284
7tmA_GPR146 cd14990
G protein-coupled receptor 146, member of the class A family of seven-transmembrane G ...
47-326 7.17e-07

G protein-coupled receptor 146, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR146 is an orphan G-protein coupled receptor that belongs to the class A of seven-transmembrane GPCR superfamily. The endogenous ligand for GPR146 is not known. It has been suggested that GPR146 may be a part of the C-peptide signaling complex. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320121  Cd Length: 280  Bit Score: 50.16  E-value: 7.17e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  47 LSFIYIFI-FVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLvQHNQWPM---GELTCKVTHL 122
Cdd:cd14990   2 LSLLYLIIcFPVGLCYNALLVLVNLYNKASMTMPDVYFVNMAIAGLVLNAVAPVQLLGP-DNTRWPLwnsNNEVYITLLI 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 123 IFSINLFGSIFFLTCMSVDRY----LSITYFTNTPSSRKkmvrrvVCILVWLLAFCVSLPD-TYYLKTVTSASNNEtyCR 197
Cdd:cd14990  81 LFNVSSLVSMYSTTLLSLDYYieraLPRTYMSSVYNTKH------VCGFIWGGAVLTSFSSlLFYICSHVSTKIIE--CS 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 198 SFYPEHSikewligMELVSVVLGFAVPfsIIAVFYFLL--------ARAISASSDQEKHSSRKIIFSYVVVFLVCWLPYH 269
Cdd:cd14990 153 KMQNKEA-------ADAIMVFIGYVVP--ALAVLYALVlilrirkeATPLDQDSGRLDPSAHRLLLATVCTQFLLWTPYY 223
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 31083344 270 VAVLLDIFSILHYIPFTCrlehALFTALHVTQCLS--LVHCC--VNPVLYSFINRNYRYEL 326
Cdd:cd14990 224 MILLVHTVQASRGKKVDA----GYLRVFHFLKGLSklLAFSSsfVVPLLYRYMNKNFSSKL 280
7tmA_GPR135 cd15212
G protein-coupled receptor 135, member of the class A family of seven-transmembrane G ...
54-321 7.70e-07

G protein-coupled receptor 135, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR135, also known as the somatostatin- and angiotensin-like peptide receptor (SALPR), is found in various tissues including eye, brain, cervix, stomach, and testis. Pharmacological studies have shown that relaxin-3 (R3) is a high-affinity endogenous ligand for GPR135. R3 has recently been identified as a new member of the insulin/relaxin family of peptide hormones and is exclusively expressed in the brain neurons. In addition to GPR135, R3 also acts as an agonist for GPR142, a pseudogene in the rat, and can activate LGR7 (leucine repeat-containing G-protein receptor-7), which is the main receptor for relaxin-1 (R1) and relaxin-2 (R2). While R1 and R2 are hormones primarily associated with reproduction and pregnancy, R3 is involved in neuroendocrine and sensory processing. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320340 [Multi-domain]  Cd Length: 285  Bit Score: 50.15  E-value: 7.70e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  54 IFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLW-VVLTIPVWVVSLVQHNQWPMGELTCKVTHLIFSINLFGSI 132
Cdd:cd15212  10 IFLLSSLGNCAVIGVIVKHRQLRTVTNAFILSLSLSDLLtALLCLPFAFLTLFSRPGWLFGDRLCLANGFFNACFGIVST 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 133 FFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCilVWLLAFCVSLPdTYYLKTVTSASNNETYCRSFYPEHSIKEWL-IG 211
Cdd:cd15212  90 LTMTLISFDRYYAIVRQPQGKIGRRRALQLLAA--AWLTALGFSLP-WYLLASAPEYYEKLGFYHCLYVLHSGPSRLgAA 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 212 MELVSVVLGFAVPFSIIAVFYFLLARAISASSDQEK------HSSR--------KIIFSYVVVFLVCWLPYHVAVLLdif 277
Cdd:cd15212 167 YSSVLIVLCYLLPFALMCFCHYNICKTVRLSESRVRpvttyaHLLRfysemrtaTTVLIMIVFIICCWGPYCLLGLV--- 243
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 31083344 278 silhyipftCRLEHALFTALHVTQCLSLV--HCCVNPVLYSFINRN 321
Cdd:cd15212 244 ---------AAAGGYQFPPLMDTVAIWMAwaNGAINPLIYAIRNPN 280
7tmA_mAChR_DM1-like cd15301
muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G ...
82-323 8.87e-07

muscarinic acetylcholine receptor DM1, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes muscarinic acetylcholine receptor DM1-like from invertebrates. Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320428 [Multi-domain]  Cd Length: 270  Bit Score: 49.82  E-value: 8.87e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  82 YILNLAIADLWV-VLTIPVWVVSLVqHNQWPMGELTCKVTHLIFSINLFGSIFFLTCMSVDRYLSITYfTNTPSSRKKMV 160
Cdd:cd15301  38 FLFSLAVADFAIgVISMPLFTVYTA-LGYWPLGYEVCDTWLAIDYLASNASVLNLLIISFDRYFSVTR-PLTYRARRTTK 115
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 161 RRVVCIL-VWLLAFCVSLPDTY---YLKTVTSASNNETYCRSFYPEHSIKewligmeLVSVVLGFAVPFSIIAVFYFLLA 236
Cdd:cd15301 116 KAAVMIAsAWIISLLLWPPWIYswpYIEGKRTVPAGTCYIQFLETNPYVT-------FGTALAAFYVPVTIMCILYWRIW 188
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 237 RAISASSDQEKHSSRKIIFSYVVVFLVCWLPYHVAVLLD-IFSILHYIPftcrleHALFTALHVtqcLSLVHCCVNPVLY 315
Cdd:cd15301 189 RETKKRQKKQESKAAKTLSAILLAFIVTWTPYNVLVLIKaFFPCSDTIP------TELWDFSYY---LCYINSTINPLCY 259

                ....*...
gi 31083344 316 SFINRNYR 323
Cdd:cd15301 260 ALCNAAFR 267
7tmA_V2R cd15388
vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled ...
54-326 1.03e-06

vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors; The vasopressin type 2 receptor (V2R) is a G(s)-coupled receptor that controls balance of water and sodium ion by regulating their reabsorption in the renal collecting duct. Mutations of V2R is responsible for nephrogenic diabetes insipidus. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320510 [Multi-domain]  Cd Length: 295  Bit Score: 49.77  E-value: 1.03e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  54 IFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWV----VLTIPVWVVSlvqhNQWPMGELTCKVTHLIFSINLF 129
Cdd:cd15388  10 IFACALLSNSLVLLVLWRRRKQLARMHVFMLHLCIADLVVaffqVLPQLVWDIT----DRFRGPDVLCRLVKYLQVVGMF 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 130 GSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCIlVWLLAFCVSLPDTYYLKTVTSASNNETYCRSFYPEHSIKEWL 209
Cdd:cd15388  86 ASSYMIVAMTFDRHQAICRPMVTFQKGRARWNGPVCV-AWAISLILSLPQVFIFSKVEVAPGVYECWACFIEPWGLKAYV 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 210 IGMELVSvvlgFAVPFSIIAVFYFLLARAISAS------------SDQEKHSSR---------------KIIFSYVVVFL 262
Cdd:cd15388 165 TWITLVV----FVLPTLIITVCQVLIFKEIHINiylksqiivavvKKKQLLSSRassvaevskamiktvKMTLVIVLVYV 240
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 31083344 263 VCWLPYHVAVLLDIFSIlhyipfTCRLEHALFTALHVtqcLSLVHCCVNPVLYSFINRNYRYEL 326
Cdd:cd15388 241 LCWAPFFLVQLWSVWDP------KAPTEGATFTILML---LASLNSCTNPWIYMAFSSSVSKEL 295
7tmA_Relaxin_R cd15137
relaxin family peptide receptors, member of the class A family of seven-transmembrane G ...
52-267 1.09e-06

relaxin family peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes relaxin/insulin-like family peptide receptor 1 (RXFP1 or LGR7) and 2 (RXFP2 or LGR8), which contain a very large extracellular N-terminal domain with numerous leucine-rich repeats responsible for hormone recognition and binding. Relaxin is a member of the insulin superfamily that has diverse actions in both reproductive and non-reproductive tissues. The relaxin-like peptide family includes relaxin-1, relaxin-2, and the insulin-like (INSL) peptides such as INSL3, INSL4, INSL5 and INSL6. The relaxin family peptides share high structural but low sequence similarity, and exert their physiological functions by activating a group of four GPCRs, RXFP1-4. Relaxin and INSL3 are the endogenous ligands for RXFP1 and RXFP2, respectively. Upon receptor binding, relaxin activates a variety of signaling pathways to produce second messengers such as cAMP.


Pssm-ID: 320265 [Multi-domain]  Cd Length: 284  Bit Score: 49.51  E-value: 1.09e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  52 IFIFVIGMIA---NSVVVWVNIQAKTTGYDTHCYILNLAIADLW--VVLTIpVWVVSL------VQHNQWPMGELTCKVT 120
Cdd:cd15137   5 VFIWVVGIIAllgNLFVLIWRLKYKEENKVHSFLIKNLAIADFLmgVYLLI-IASVDLyyrgvyIKHDEEWRSSWLCTFA 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 121 HLIFSINLFGSIFFLTCMSVDRYLSITY-FTNTPSSRKKMvrRVVCILVWLLAFCVS-LPDTYYLktvtsasnnetYCRS 198
Cdd:cd15137  84 GFLATLSSEVSVLILTLITLDRFICIVFpFSGRRLGLRRA--IIVLACIWLIGLLLAvLPLLPWD-----------YFGN 150
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 199 FY-------PEHSIKEWLIGMEL-VSVVLGF-AVPFSIIAVFYFLLARAISASSDQEKHSSRK--IIFSYVVVFLV---- 263
Cdd:cd15137 151 FYgrsgvclPLHITDERPAGWEYsVFVFLGLnFLAFVFILLSYIAMFISIRRTRKAAASRKSKrdMAVAKRFFLIVltdf 230

                ....*
gi 31083344 264 -CWLP 267
Cdd:cd15137 231 lCWIP 235
7tmA_mAChR_M1 cd17790
muscarinic acetylcholine receptor subtype M1, member of the class A family of ...
42-323 1.42e-06

muscarinic acetylcholine receptor subtype M1, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. M1 is the dominant mAChR subtype involved in learning and memory. It is linked to synaptic plasticity, neuronal excitability, and neuronal differentiation during early development. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341356 [Multi-domain]  Cd Length: 262  Bit Score: 49.20  E-value: 1.42e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  42 VLLYTLSFIYIFIFVIGMIANSVVVWVNIQAKTTgydTHCYILNLAIADLWV-VLTIPVWVVSLVQhNQWPMGELTCKVT 120
Cdd:cd17790   1 VLIVITTGILSLVTVTGNLLVLISFKVNSELKTV---NNYFLLSLACADLIIgAFSMNLYTTYILM-GHWALGTVACDLW 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 121 HLIFSINLFGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDTYYLKTVTSASNNE-TYCRSF 199
Cdd:cd17790  77 LALDYVASNASVMNLLIISFDRYFSITRPLTYRAKRTPRRAAIMIGLAWLISFVLWAPAILFWQYLVGERTVLaGQCYIQ 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 200 YPEHSIkewligMELVSVVLGFAVPFSIIAVFYFLLARaisaSSDQEKHSSRKIIfSYVVVFLVCWLPYHVAVLLDIFsi 279
Cdd:cd17790 157 FLSQPI------ITFGTAIAAFYLPVTIMIILYWRIYR----ETIKEKKAARTLS-AILLAFILTWTPYNIMVLVSTF-- 223
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 31083344 280 lhyipftCRlEHALFTALHVTQCLSLVHCCVNPVLYSFINRNYR 323
Cdd:cd17790 224 -------CK-DCVPKTLWELGYWLCYVNSTVNPMCYALCNKSFR 259
7tmA_TAAR2_3_4 cd15312
trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family ...
79-277 1.91e-06

trace amine-associated receptors 2, 3, 4, and similar receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; TAAR2, TAAR3, and TAAR4 are among the 15 identified trace amine-associated receptor subtypes, which form a distinct subfamily within the class A G protein-coupled receptor family. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320437 [Multi-domain]  Cd Length: 289  Bit Score: 48.89  E-value: 1.91e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  79 THCYILNLAIADLWVVLTI-PVWVVSLVQhNQWPMGELTCKVtHLIFSINL-FGSIFFLTCMSVDRYLSITYftntP-SS 155
Cdd:cd15312  35 TNFLILSLAITDFLLGFLVmPYSMVRSVE-SCWYFGDLFCKI-HSSLDMMLsTTSIFHLCFIAVDRYYAVCD----PlHY 108
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 156 RKKMVRRVVCILvwlLAFCVSLPDTYYLKTVTSASNNE--------TYCRSFYPEHSIKEWligmELVSVVLGFAVPFSI 227
Cdd:cd15312 109 RTKITTPVIKVF---LVISWSVPCLFAFGVVFSEVNLEgiedyvalVSCTGSCVLIFNKLW----GVIASLIAFFIPGTV 181
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 31083344 228 IAVFY---FLLAR----AISASSDQEKHSSRKII-----------FSYVV-VFLVCWLPYHVAVLLDIF 277
Cdd:cd15312 182 MIGIYikiFFVARkhakVINNRPSVTKGDSKNKLskkkerkaaktLSIVMgVFLLCWLPFFVATLIDPF 250
PHA03234 PHA03234
DNA packaging protein UL33; Provisional
79-347 1.94e-06

DNA packaging protein UL33; Provisional


Pssm-ID: 177562 [Multi-domain]  Cd Length: 338  Bit Score: 49.17  E-value: 1.94e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344   79 THCYILNLAIADLwvVLTIPVWVVSLVQHNQWPMGELTCKVTHLIFSINLFGSIFFLTCMSVDRYLSITYFTNTpSSRKK 158
Cdd:PHA03234  69 TSFYLITLFASDF--LHMLCVFFLTLNREALFNFNQAFCQCVLFIYHASCSYSICMLAIIATIRYKTLHRRKKN-DKKNN 145
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  159 MVRRVVCILVWLLAFCvSLPDTYYLKTvTSASNNETYCRSFYPEHSIKEWLIGMELVSVVLGFAVPFSIIAVFYFLLARA 238
Cdd:PHA03234 146 HIGRNIGILFLASAMC-AIPAALFVKT-EGKKGNYGKCNIHISSKKAYDLFIAIKIVFCFIWGIFPTMIFSFFYVIFCKA 223
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  239 ISASSDQEKHSSRKIIFSYVVVFLVCWLPYHVAVLLDIFSIlhYIPFTCRLEHALFTALH-VTQCLSLVHCCVNPVLYSF 317
Cdd:PHA03234 224 LHALTEKKHKKTLFFIRILILSFLCIQIPNIAILICEIAFL--YIANNSCFGLAQREILQiIIRLMPEIHCFSNPLVYAF 301
                        250       260       270
                 ....*....|....*....|....*....|...
gi 31083344  318 INRNYR---YELMKAFIFKYSAKTGLTKLIDAS 347
Cdd:PHA03234 302 TGGDFRlrfTACFQDFFKCNLCNSQKKKDRDAL 334
7tmA_5-HT1A_invertebrates cd15331
serotonin receptor subtype 1A from invertebrates, member of the class A family of ...
83-323 2.42e-06

serotonin receptor subtype 1A from invertebrates, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320454 [Multi-domain]  Cd Length: 261  Bit Score: 48.50  E-value: 2.42e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  83 ILNLAIADLWV-VLTIPVWVVSLVQHnQWPMGELTCKVTHLIFSINLFGSIFFLTCMSVDRYLSITyftNTPSSRKKMVR 161
Cdd:cd15331  39 ILSLAVADLMVaVLVMPLSAVYEVSQ-HWFLGPEVCDMWISMDVLCCTASILHLVAIALDRYWAVT---NIDYIRRRTAK 114
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 162 RV--VCILVWLLAFCVSLPDTYYLKtvtsasNNETYCRSFYPEHSIKEWLIGMELVSVVLGFAVPFSIIAVFYFLLARAi 239
Cdd:cd15331 115 RIliMIAVVWFVSLIISIAPLFGWK------DEDDLDRVLKTGVCLISQDYGYTIFSTVGAFYVPLLLMIIIYWKIYQA- 187
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 240 sasSDQEKHSSR--KIIFSyvvVFLVCWLPYHVAVLldifsilhYIPFtCRLEHALFTALHVTQCLSLVHCCVNPVLYSF 317
Cdd:cd15331 188 ---AKRERKAARtlAIITG---AFVVCWLPFFLVAL--------VMPF-CGAWQISRFLESFFLWLGYFNSLLNPIIYTI 252

                ....*.
gi 31083344 318 INRNYR 323
Cdd:cd15331 253 FSPDFR 258
7tmA_Adenosine_R_A2B cd15069
adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G ...
52-324 2.57e-06

adenosine receptor subtype 2AB, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2B receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320197 [Multi-domain]  Cd Length: 294  Bit Score: 48.39  E-value: 2.57e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  52 IFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWV-VLTIPVWV-VSL-VQHNQWPMGELTCKVTHLIFSinl 128
Cdd:cd15069   8 LIIAALSVAGNVLVCAAVGTNSTLQTPTNYFLVSLAAADVAVgLFAIPFAItISLgFCTDFHSCLFLACFVLVLTQS--- 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 129 fgSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDTYYLKTVTSASNNET------------YC 196
Cdd:cd15069  85 --SIFSLLAVAVDRYLAIKVPLRYKSLVTGKRARGVIAVLWVLAFGIGLTPFLGWNKAMSATNNSTnpadhgtnhsccLI 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 197 RSFYPEHSIKEWLIGMELVSVVLGFAVPFSIIAVFYFLLA-RAI--------SASSDQEKHSSRKIIFSYVVVFLVCWLP 267
Cdd:cd15069 163 SCLFENVVPMSYMVYFNFFGCVLPPLLIMLVIYIKIFLVAcRQLqrtelmdhSRTTLQREIHAAKSLAIIVGIFALCWLP 242
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 31083344 268 YHVavlLDIFSILHYIPFTCRLEHALFTALhvtqCLSLVHCCVNPVLYSFINRNYRY 324
Cdd:cd15069 243 VHI---LNCITLFQPEFSKSKPKWAMNVAI----LLSHANSVVNPIVYAYRNRDFRY 292
7tmA_EDG-like cd14972
endothelial differentiation gene family, member of the class A family of seven-transmembrane G ...
48-323 3.23e-06

endothelial differentiation gene family, member of the class A family of seven-transmembrane G protein-coupled receptors; This group represents the endothelial differentiation gene (Edg) family of G-protein coupled receptors, melanocortin/ACTH receptors, and cannabinoid receptors as well as their closely related receptors. The Edg GPCRs bind blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). Melanocortin receptors bind a group of pituitary peptide hormones known as melanocortins, which include adrenocorticotropic hormone (ACTH) and the different isoforms of melanocyte-stimulating hormones. Two types of cannabinoid receptors, CB1 and CB2, are activated by naturally occurring endocannabinoids, cannabis plant-derived cannabinoids such as tetrahydrocannabinol, or synthetic cannabinoids. The CB receptors are involved in the various physiological processes such as appetite, mood, memory, and pain sensation. CB1 receptor is expressed predominantly in central and peripheral neurons, while CB2 receptor is found mainly in the immune system.


Pssm-ID: 341317 [Multi-domain]  Cd Length: 275  Bit Score: 48.06  E-value: 3.23e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  48 SFIYIFIFVIGMIANSVV---VWVNIQAKTTGYdthCYILNLAIADLwVVLTIPVWVVSLVQHNQWPMGELTCKVTHLIF 124
Cdd:cd14972   2 LVVAIVLGVFIVVENSLVlaaIIKNRRLHKPMY---ILIANLAAADL-LAGIAFVFTFLSVLLVSLTPSPATWLLRKGSL 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 125 SINLFGSIFFLTCMSVDRYLSITY--FTNTPSSRKKMVrrVVCILVWLLAFCVSLPDTYYLKTVTSASNNETYCRSFYPE 202
Cdd:cd14972  78 VLSLLASAYSLLAIAVDRYISIVHglTYVNNVTNKRVK--VLIALVWVWSVLLALLPVLGWNCVLCDQESCSPLGPGLPK 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 203 HSIKEWLIgmelvsvvlGFAVPFSIIAVFY-----------FLLARAISASSDQEKHSSRKIIFSYV---VVFLVCWLPY 268
Cdd:cd14972 156 SYLVLILV---------FFFIALVIIVFLYvrifwclwrhaNAIAARQEAAVPAQPSTSRKLAKTVVivlGVFLVCWLPL 226
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 31083344 269 HVAVLLDIFsilhyIPFTCRLEHALFTALHVTQCLSLvhccVNPVLYSFINRNYR 323
Cdd:cd14972 227 LILLVLDVL-----CPSVCDIQAVFYYFLVLALLNSA----INPIIYAFRLKEMR 272
7tmA_GPR141 cd14994
orphan G protein-coupled receptor 141, member of the class A family of seven-transmembrane G ...
45-269 4.79e-06

orphan G protein-coupled receptor 141, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup represents the G-protein coupled receptor 141 of unknown function. Several ESTs for GPR141 were found in marrow and cancer cells. GPR141 is a member of the rhodopsin-like, class A GPCRs, which is a widespread protein family that includes the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320125  Cd Length: 275  Bit Score: 47.48  E-value: 4.79e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  45 YTLSFIYIFIFVIGMIANSVVVWVnIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVQHnQWPMGELTCKVTHLIF 124
Cdd:cd14994   2 YSLIFLYSVVLIGGVIGVILMSFL-LVKMNTRSVTTTAVINLIVVHSLFLLTVPFRIYYYASK-TWKFGMPLCKMVSAMI 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 125 SINLFGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPdTYYLKTVTSASNNETYCRSFYPE-- 202
Cdd:cd14994  80 HIHMHLTFLFYVIILVIRYLIFFQRKDKMEFYRKLHAVAASAVVWVLVLLIVVP-VFVKEYGSSSSYNSDQCFKFHKEle 158
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 31083344 203 -HSIK--EWLIGMELVSVVLGFAVPFSIIAVfyfLLARAISAS--SDQEKHSSRKIIFsYVVVFLVCWLPYH 269
Cdd:cd14994 159 vHYVKvlNYIIICIVLIVTLALLGFQVFILG---HVYRKLRASllSHQEFWAQMKSLF-FIVVIIVCFVPYN 226
7tmA_GPR119_R_insulinotropic_receptor cd15104
G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member ...
75-326 5.64e-06

G protein-coupled receptor 119, also called glucose-dependent insulinotropic receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR119 is activated by oleoylethanolamide (OEA), a naturally occurring bioactive lipid with hypophagic and anti-obesity effects. Immunohistochemistry and double-immunofluorescence studies revealed the predominant GPR119 localization in pancreatic polypeptide (PP)-cells of islets. In addition, GPR119 expression is elevated in islets of obese hyperglycemic mice as compared to control islets, suggesting a possible involvement of this receptor in the development of obesity and diabetes. GPR119 has a significant sequence similarity with the members of the endothelial differentiation gene family. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320232 [Multi-domain]  Cd Length: 283  Bit Score: 47.37  E-value: 5.64e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  75 TGYDTHCYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVTHLIFSINLFGSIFFLTCMSVDRYLSIT---YFTN 151
Cdd:cd15104  31 KDTKSNCFLLNLAIADFLVGLAIPGLATDELLSDGENTQKVLCLLRMCFVITSCAASVLSLAAIAFDRYLALKqplRYKQ 110
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 152 TpSSRKKMVRRVVciLVWLLAFCV-SLPDTYylkTVTSASNNETYCRSFYPEHsiKEWLigmeLVSVVLGFAVPFSIIAV 230
Cdd:cd15104 111 I-MTGKSAGALIA--GLWLYSGLIgFLPLIS---PQFQQTSYKGKCSFFAAFH--PRVL----LVLSCMVFFPALLLFVF 178
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 231 FY---FLLARAIS-ASSDQEKHSSRKIIFSYVV--------------VFLVCWLPYHVAVLLDIFSIlhyipfTCRLEHA 292
Cdd:cd15104 179 CYcdiLKIARVHSrAIYKVEHALARQIHPRRTLsdfkaartvavligCFLLSWLPFQITGLVQALCD------ECKLYDV 252
                       250       260       270
                ....*....|....*....|....*....|....
gi 31083344 293 LFTALHVtqcLSLVHCCVNPVLYSFINRNYRYEL 326
Cdd:cd15104 253 LEDYLWL---LGLCNSLLNPWIYAFWQKEVRRAL 283
7tmA_Histamine_H2R cd15051
histamine subtype H2 receptor, member of the class A family of seven-transmembrane G ...
42-324 7.61e-06

histamine subtype H2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes histamine receptor subtype H2R, a member of histamine receptor family, which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H2R subtype selectively interacts with the G(s)-type G protein that activates adenylate cyclase, leading to increased cAMP production and activation of Protein Kinase A. H2R is found in various tissues such as the brain, stomach, and heart. Its most prominent role is in histamine-induced gastric acid secretion. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320179 [Multi-domain]  Cd Length: 287  Bit Score: 46.94  E-value: 7.61e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  42 VLLYTLSFIYIFIFVIGMIANSVVVWVNIQAKTTgydTHCYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVTH 121
Cdd:cd15051   1 IVLGVVLAVIILLTVIGNVLVCLAVAVNRRLRNL---TNYFIVSLAVTDLLLGLLVLPFSAIYELRGEWPLGPVFCNIYI 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 122 LIFSINLFGSIFFLTCMSVDRYLSIT----YftntpsSRKKMVRRVVCIL--VWLLAFCVS-LPDTYYLKTVTSASNN-- 192
Cdd:cd15051  78 SLDVMLCTASILNLFAISLDRYLAITaplrY------PSRVTPRRVAIALaaIWVVSLAVSfLPIHLGWNTPDGRVQNgd 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 193 -ETYCRSfypehsikEWLIGMELVSVVLGFAVPFSIIAVFYFLL-------ARAISASSDQEKHSSRKIIFS-------- 256
Cdd:cd15051 152 tPNQCRF--------ELNPPYVLLVAIGTFYLPLLIMCGVYLRIfriareqAKRINALTPASTANSSKSAATarehkatv 223
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 31083344 257 ----YVVVFLVCWLPYhvavlldiFSILHYIPFtcRLEHALFTALHVTQCLSLVHCCVNPVLYSFINRNYRY 324
Cdd:cd15051 224 tlaaVLGAFIICWFPY--------FTYFTYRGL--CGDNINETALSVVLWLGYANSALNPILYAFLNRDFRR 285
7tmA_5-HT1B_1D cd15333
serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G ...
46-323 1.28e-05

serotonin receptor subtypes 1B and 1D, member of the class A family of seven-transmembrane G protein-coupled receptors; The 5-HT1 receptors, one of 14 mammalian 5-HT receptors, is a member of the class A of GPCRs and is activated by the endogenous neurotransmitter and peripheral signal mediator serotonin (5-hydroxytryptamine, 5-HT). The 5-HT1 receptors mediate inhibitory neurotransmission by coupling to G proteins of the G(i/o) family, which lead to a decrease in adenylate cyclase activity, thereby decreasing intracellular cAMP levels and calcium influx. The 5-HT1 receptor subfamily includes 5 subtypes: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, and 5-HT1F. There is no 5-HT1C receptor subtype, as it has been reclassified as the 5-HT2C receptor. In the CNS, serotonin is involved in the regulation of appetite, mood, sleep, cognition, learning and memory, as well as implicated in neurologic disorders such as migraine, schizophrenia, and depression.


Pssm-ID: 320455 [Multi-domain]  Cd Length: 265  Bit Score: 46.33  E-value: 1.28e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  46 TLSFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWV-VLTIPVWVVSLVQHnQWPMGELTCKVTHLIF 124
Cdd:cd15333   6 SLAVLLALITLATTLSNAFVIATIYLTRKLHTPANYLIASLAVTDLLVsILVMPISIVYTVTG-TWTLGQVVCDIWLSSD 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 125 SINLFGSIFFLTCMSVDRYLSITYFTNTpSSRKKMVRRVVCI-LVWLLAFCVSLPDTYYLKTvtSASNNETYCrsfypeh 203
Cdd:cd15333  85 ITCCTASILHLCVIALDRYWAITDAVEY-SKKRTPKRAAVMIaLVWVISISISLPPFFWRQA--KAEEEVSEC------- 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 204 SIKEWLIGMELVSVVLGFAVPFSIIAVFYfllARAISASSDQEKHSSrKIIFSYVVVFLVCWLPYHVAVLldifsILHYI 283
Cdd:cd15333 155 VVNTDHILYTVYSTVGAFYIPTLLLIALY---GRIYVEARARERKAT-KTLGIILGAFIVCWLPFFIISL-----VLPIC 225
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 31083344 284 PFTCRLEHALFTalhVTQCLSLVHCCVNPVLYSFINRNYR 323
Cdd:cd15333 226 KDACWFHLAIFD---FFTWLGYLNSLINPIIYTMSNEDFK 262
7tmA_GPR45 cd15403
G protein-coupled receptor 45, member of the class A family of seven-transmembrane G ...
46-323 2.31e-05

G protein-coupled receptor 45, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the human orphan receptor GPR45 and closely related proteins found in vertebrates. GPR45 is also called PSP24 in Xenopus and PSP24-alpha (or PSP24-1) in mammals. GPR45 shows the highest sequence homology with GPR63 (PSP24-beta, or PSP24-2). PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Mammalian PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320525 [Multi-domain]  Cd Length: 301  Bit Score: 45.61  E-value: 2.31e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  46 TLSFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWV-VLTIPVWVVSLVQHNqWPMGELTCKVTHLIF 124
Cdd:cd15403   2 LLAIVMILMIAIGFLGNAIVCLIVYQKPAMRSAINLLLATLAFSDIMLsLLCMPFTAVTIITVD-WHFGAHFCRISAMLY 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 125 SINLFGSIFFLTCMSVDRYLSITYFTNTPSSRKKmvrRVVCILVWLLAFCVSLPDTYYLkTVTSASNNETYCRSFYPEHS 204
Cdd:cd15403  81 WFFVLEGVAILLIISVDRFLIIVQRQDKLNPHRA---KVMIAISWVLSFCISFPSVVGW-TLVEVPARAPQCVLGYTESP 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 205 IKEWLIGMELVSVvlgFAVPFSIIAVFYFL-------------------------------LARAISASSDQE-KHSSRK 252
Cdd:cd15403 157 ADRVYAVLLVVAV---FFVPFSIMLYSYLCilntvrrnavrihnhadslclsqvsklglmgLQRPHQMNVDMSfKTRAFT 233
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 31083344 253 IIFSYVVVFLVCWLPYHVAVLLDIFSILHYipftcrLEHALFTALHVTQCLSLVHCCVNPVLYSFINRNYR 323
Cdd:cd15403 234 TILILFVGFSLCWLPHTVFSLLSVFSRRFY------YSSSFYPISTCVLWLSYLKSVFNPVIYCWRIKKFR 298
7tmA_SREB2_GPR85 cd15218
super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of ...
53-178 2.42e-05

super conserved receptor expressed in brain 2 (or GPR85), member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320346 [Multi-domain]  Cd Length: 330  Bit Score: 45.79  E-value: 2.42e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  53 FIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIAD-LWVVLTIPVWVVSLVQHNQWPMGELTCKVTHLIFSINLFGS 131
Cdd:cd15218   9 FIIGVSVVGNLLISILLVKDKTLHRAPYYFLLDLCCSDiLRSAICFPFVFTSVKNGSTWTYGTLTCKVIAFLGVLSCFHT 88
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 31083344 132 IFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLP 178
Cdd:cd15218  89 AFMLFCISVTRYLAIAHHRFYTKRLTFWTCLAVICMVWTLSVAMAFP 135
7tmA_Pinopsin cd15084
non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled ...
35-328 2.75e-05

non-visual pinopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Pinopsins are found in the pineal organ of birds, reptiles and amphibians, but are absent from teleosts and mammals. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Pinopsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320212 [Multi-domain]  Cd Length: 295  Bit Score: 45.24  E-value: 2.75e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  35 PNMPNKSVLLyTLSFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGE 114
Cdd:cd15084   2 PHLAPRSTYL-TVAVLMGMVVALASFVNGLVIVVSIKYKKLRSPLNYILVNLAVADLLVTLFGSSVSFSNNIVGFFVFGK 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 115 LTCKVTHLIFSINLFGSIFFLTCMSVDRYLSITyftnTPSSRKKMVRR---VVCILVWLLAFCVSLPDTYY--------L 183
Cdd:cd15084  81 TMCEFEGFMVSLTGIVGLWSLAILAFERYLVIC----KPMGDFRFQQRhavSGCAFTWGWSLLWTSPPLFGwssyvpegL 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 184 KT------VTSASNNETYCRSFYpehsikewligmelvsvVLGFAVPFSIIAVFYFLLARAISASSDQEKHSSR------ 251
Cdd:cd15084 157 RTscgpnwYTGGTNNNSYILALF-----------------VTCFALPLSTIIFSYSNLLLTLRAVAAQQKESETtqraek 219
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 252 ---KIIFSYVVVFLVCWLPYHVavlldiFSILHYIPFTCRLEHALFTalhVTQCLSLVHCCVNPVLYSFINRNYRYELMK 328
Cdd:cd15084 220 evtRMVIAMVMAFLICWLPYAT------FAMVVATNKDVVIQPTLAS---LPSYFSKTATVYNPIIYVFMNKQFRSCLLE 290
7tmA_GPR63 cd15404
G protein-coupled receptor 63, member of the class A family of seven-transmembrane G ...
46-278 3.78e-05

G protein-coupled receptor 63, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes the human orphan receptor GPR63, which is also called PSP24-beta or PSP24-2, and its closely related proteins found in vertebrates. GPR63 shares the highest sequence homology with GPR45 (Xenopus PSP24, mammalian PSP24-alpha or PSP24-1). PSP24 was originally identified as a novel, high-affinity lysophosphatidic acid (LPA) receptor in Xenopus laevis oocytes; however, PSP24 receptors (GPR45 and GPR63) have not been shown to be activated by LPA. Mammalian PSP24 receptors are highly expressed in neuronal cells of cerebellum and their expression level remains constant from the early embryonic stages to adulthood, suggesting the important role of PSP24s in brain neuronal functions. Members of this subgroup contain the highly conserved Asp-Arg-Tyr/Phe (DRY/F) motif found in the third transmembrane helix (TM3) of the rhodopsin-like class A receptors which is important for efficient G protein-coupled signal transduction. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320526 [Multi-domain]  Cd Length: 265  Bit Score: 44.83  E-value: 3.78e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  46 TLSFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWV-VLTIPVWVVSLVQhNQWPMGELTCKVTHLIF 124
Cdd:cd15404   2 ILSAVMIFILLVSFLGNFVVCLMVYQKAAMRSAINILLASLAFADMMLaVLNMPFALVTIIT-TRWIFGDAFCRVSAMFF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 125 SINLFGSIFFLTCMSVDRYLSITYFTNTPSSRKKmvrRVVCILVWLLAFCVSLPDTYYLKTVTSASNNETYCRSFYPEHS 204
Cdd:cd15404  81 WLFVMEGVAILLIISIDRFLIIVQKQDKLNPYRA---KVLIAVSWAVSFCVAFPLAVGSPDLQIPSRAPQCVFGYTTNPG 157
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 31083344 205 IKEWLIGMELVSvvlgFAVPFSIIAVFYFLLARAISASsdqeKHSSRKIIFSYVVVFLVCWLPYHVAVLLDIFS 278
Cdd:cd15404 158 YQAYVILIMLIF----FFIPFMVMLYSFMGILNTVRSF----KTRAFTTILILFIVFTVCWAPFTTYSLVATFN 223
7tmA_Beta_AR cd15058
beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane ...
47-277 4.55e-05

beta adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta adrenergic receptor (beta adrenoceptor), also known as beta AR, is activated by hormone adrenaline (epinephrine) and plays important roles in regulating cardiac function and heart rate, as well as pulmonary physiology. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of beta-ARs can lead to cardiac dysfunction such as arrhythmias or heart failure. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320186 [Multi-domain]  Cd Length: 305  Bit Score: 44.75  E-value: 4.55e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  47 LSFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWV-VLTIPVWVvSLVQHNQWPMGELTCKVTHLIFS 125
Cdd:cd15058   3 LLLLLALIILAIVVGNLLVIIAIARTSRLQTMTNIFITSLACADLVMgLLVVPLGA-TIVVTGKWQLGNFWCELWTSVDV 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 126 INLFGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVS-LPDTYYLKTVTSASNNETY----CRSFY 200
Cdd:cd15058  82 LCVTASIETLCVIAVDRYIAITRPLRYQVLLTKRRARVIVCVVWIVSALVSfVPIMNQWWRANDPEANDCYqdptCCDFR 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 201 PEHSikewligMELVSVVLGFAVPFSIIAVFY---FLLA------------RAISASSDQEKHSSRKIIFSY-------- 257
Cdd:cd15058 162 TNMA-------YAIASSVVSFYIPLLIMIFVYarvFLIAtrqlqlidkrrlRFQSECPAPQTTSPEGKRSSGrrpsrltv 234
                       250       260       270
                ....*....|....*....|....*....|...
gi 31083344 258 -------------VVVFLVCWLPYHVAVLLDIF 277
Cdd:cd15058 235 vkehkalktlgiiMGTFTLCWLPFFIANIINVF 267
7tmA_tmt_opsin cd15086
teleost multiple tissue (tmt) opsin, member of the class A family of seven-transmembrane G ...
53-322 7.55e-05

teleost multiple tissue (tmt) opsin, member of the class A family of seven-transmembrane G protein-coupled receptors; Teleost multiple tissue (tmt) opsins are homologs of encephalopsin. Mouse encephalopsin (or panopsin) is highly expressed in the brain and testes, whereas the teleost homologs are localized to multiple tissues. The exact functions of the encephalopsins and tmt-opsins are unknown. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Tmt opsins belong to the class A of the G protein-coupled receptors and show strong homology to the vertebrate visual opsins.


Pssm-ID: 320214 [Multi-domain]  Cd Length: 276  Bit Score: 43.96  E-value: 7.55e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  53 FIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVTHliFSINLFG-- 130
Cdd:cd15086   9 FILTFGFLNNLLVLVLFCKYKVLRSPINLLLLNISLSDLLVCVLGTPFSFAASTQGRWLIGEHGCRWYG--FANSLFGiv 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 131 SIFFLTCMSVDRYLSITYFTNTPSSRKKMVRrvVCILV-WLLAFCVSLPDTYYLKTVTSASNNETyCRSFYPEHSIKEwl 209
Cdd:cd15086  87 SLISLAVLSYERYCTLLRPTEADVSDYRKAW--LGVGGsWLYSLLWTLPPLLGWSSYGPEGPGTT-CSVQWTSRSANS-- 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 210 IGMELVSVVLGFAVPFSIIAVFYFLLARAISASSDQEKHSSRK-------IIFSYVVVFLVCWLPYHVAVLLDIFSILHY 282
Cdd:cd15086 162 ISYIICLFIFCLLLPFLVMVYCYGRLLYAIKQVGKINKSTARKreqhvllMVVTMVICYLLCWLPYGVMALLATFGKPGL 241
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 31083344 283 IPFTCRLehalftalhVTQCLSLVHCCVNPVLYSFINRNY 322
Cdd:cd15086 242 VTPVASI---------VPSILAKSSTVVNPIIYVFMNKQF 272
7tmA_TAAR6_8_9 cd15316
trace amine-associated receptors 6, 8, and 9, member of the class A family of ...
42-317 8.71e-05

trace amine-associated receptors 6, 8, and 9, member of the class A family of seven-transmembrane G protein-coupled receptors; Included in this group are mammalian TAAR6, TAAR8, TAAR9, and similar proteins. They are among the 15 identified amine-associated receptors (TAARs), a distinct subfamily within the class A G protein-coupled receptors. Trace amines are endogenous amines of unknown function that have strong structural and metabolic similarity to classical monoamine neurotransmitters (serotonin, noradrenaline, adrenaline, dopamine, and histamine), which play critical roles in human and animal physiological activities such as cognition, consciousness, mood, motivation, perception, and autonomic responses. However, trace amines are found in the mammalian brain at very low concentrations compared to classical monoamines. Trace amines, including p-tyramine, beta-phenylethylamine, and tryptamine, are also thought to act as chemical messengers to exert their biological effects in vertebrates. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320439 [Multi-domain]  Cd Length: 290  Bit Score: 43.69  E-value: 8.71e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  42 VLLYTlsfIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVtH 121
Cdd:cd15316   1 VILYI---VLGFGAVLAVFGNLLVMISILHFKQLHSPTNFLIASLACADFLVGVTVMPFSTVRSVESCWYFGESFCTF-H 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 122 LIFSINL-FGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDTYylkTVTSASNNETYCRSFY 200
Cdd:cd15316  77 TCCDVSFcYASLFHLCFISVDRYIAVTDPLVYPTKFTVSVSGICISVSWIFSLTYSFSVFY---TGVNDDGLEELVNALN 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 201 PEHSIKEWLIGMELVSVVLGFAVPFSIIAVFY---FLLA----RAISASSDQEKHSSR--------------KIIFSYVV 259
Cdd:cd15316 154 CVGGCQIILNQNWVLVDFLLFFIPTFAMIILYgkiFLVAkqqaRKIEMTSSKAESSSEsykdrvarrerkaaKTLGITVI 233
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 31083344 260 VFLVCWLPYHVAVLLDIFsiLHYIPFTCRLEHALFTALHvtqclslvHCCVNPVLYSF 317
Cdd:cd15316 234 AFLVSWLPYLIDVLIDAF--MNFITPPYIYEICCWCAYY--------NSAMNPLIYAL 281
7tmA_MrgprB cd15107
mas-related G protein-coupled receptor subtype B, member of the class A family of ...
46-318 1.00e-04

mas-related G protein-coupled receptor subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined.


Pssm-ID: 320235  Cd Length: 276  Bit Score: 43.54  E-value: 1.00e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  46 TLSFIYIFIFVIGMIANSVVVW-VNIQAKTTGYDThcYILNLAIAD-LWVVLTIPVWVVSLVQHNQWPMGELTCKVTHLI 123
Cdd:cd15107   2 TMNFLSIIIALVGLAGNAIVLWlLGFHMHRNAFSV--YILNLAGADfLFLCTQIVFSLEIVLQFHSIDIHIPLFLLTVTM 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 124 FsiNLFGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDTYYLKTVTSASnNETYCRSFypEH 203
Cdd:cd15107  80 F--AYLAGLSMITAISIERCLSVMWPIWYHCQRPRHTSAVICTLLWVLSLLLSLLEGKGCGFLFSTY-DYYWCWTL--DL 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 204 SIKEWLIgmelvsvVLGFAVPFSIIAvfyfLLARAISASSDQEKHSSRKIIFSYVVVFLVCWLPYHVAVLLDIFSILHYI 283
Cdd:cd15107 155 ITTAWLI-------VLFVVLSGSSLA----LLVRIFCGSHRIPVTRLYVTIALTVLVFLIFGLPFGIYWFLLKWIEEFYI 223
                       250       260       270
                ....*....|....*....|....*....|....*
gi 31083344 284 PFTCRLehalftaLHVTQCLSLVHCCVNPVLYSFI 318
Cdd:cd15107 224 VPCCGF-------YEVILFLSCVNSCANPIIYFLV 251
7tmA_S1PR4_Edg6 cd15349
sphingosine-1-phosphate receptor subtype 4 (S1PR4 or S1P4), also called endothelial ...
126-323 1.31e-04

sphingosine-1-phosphate receptor subtype 4 (S1PR4 or S1P4), also called endothelial differentiation gene 6 (Edg6), member of the class A family of seven-transmembrane G protein-coupled receptors; The endothelial differentiation gene (Edg) family of G-protein coupled receptors binds blood borne lysophospholipids including sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA), which are involved in the regulation of cell proliferation, survival, migration, invasion, endothelial cell shape change and cytoskeletal remodeling. The Edg receptors are classified into two subfamilies: the lysophosphatidic acid subfamily that includes LPA1 (Edg2), LPA2 (Edg4), and LPA3 (Edg7); and the S1P subfamily that includes S1P1 (Edg1), S1P2 (Edg5), S1P3 (Edg3), S1P4 (Edg6), and S1P5 (Edg8). The Edg receptors couple and activate at least three different G protein subtypes including G(i/o), G(q/11), and G(12/13).


Pssm-ID: 320471 [Multi-domain]  Cd Length: 271  Bit Score: 43.23  E-value: 1.31e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 126 INLFGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDTYYLKTVTSASNnetyCRSFYPEHSi 205
Cdd:cd15349  81 TALAASTFSLLVTAVERYATMVRPVAENTATKTYRVYGMIVLCWILAFLIGFLPLLGWNCLCDFRS----CSSLLPLYS- 155
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 206 KEWLigmeLVSVVLgFAVPFSIIAVFYFLLARAISASSDQ--EKHSSR------KIIFSYVVVFLVCWLPYHVAVLLDIF 277
Cdd:cd15349 156 KSYI----LFCLVI-FFIILLTIIGLYFAIYCLVRASGQRviSARSRRrslrllKTVLMILGAFMVCWGPLFILLLVDFF 230
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*.
gi 31083344 278 SilhyIPFTCRLEHALFTALhvtqCLSLVHCCVNPVLYSFINRNYR 323
Cdd:cd15349 231 C----SSRSCKPLFGMEWVL----ALAVLNSAINPLIYSFRSLEVR 268
7tmA_Parietopsin cd15085
non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled ...
47-323 1.81e-04

non-visual parietopsins, member of the class A family of seven-transmembrane G protein-coupled receptors; Parietopsin is a non-visual green light-sensitive opsin that was initially identified in the parietal eye of lizards. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity and body color change. Parietopsin belongs to the class A of the G protein-coupled receptors and shows strong homology to the vertebrate visual opsins.


Pssm-ID: 320213 [Multi-domain]  Cd Length: 280  Bit Score: 42.92  E-value: 1.81e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  47 LSFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVTHliFSI 126
Cdd:cd15085   3 LSFLMFLNATFSIFNNVLVIAVTLKNPQLRNPINIFILNLSFSDLMMALCGTTIVTVTNYEGYFYLGDAFCIFQG--FAV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 127 NLFG--SIFFLTCMSVDRYLSITyftnTPSSRKKM-VRRVVCILVWLLAFCVSLPDTYYLKTVTSASNN-ETYCRSFYPE 202
Cdd:cd15085  81 NYFGivSLWSLTLLAYERYNVVC----KPMGGLKLsTKRGYQGLLFIWLFCLFWAVAPLFGWSSYGPEGvQTSCSIGWEE 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 203 HSIKEWliGMELVSVVLGFAVPFSIIAVFYFLLARAI------------SASSDQEKHSSRKIIFsYVVVFLVCWLPYHV 270
Cdd:cd15085 157 RSWSNY--SYLILYFLMCFVIPVAIIGFSYGNVLRSLhklnkkieqqggKNCPEEEERAVIMVLA-MVIAFLICWLPYTV 233
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 31083344 271 AVLLDIFSILHYIPftcRLEHALFTALHVTqclSLVHccvNPVLYSFINRNYR 323
Cdd:cd15085 234 FALIVVVNPELSIS---PLAATMPTYFAKT---SPVY---NPIIYIFLNKQFR 277
7tmA_mAChR_GAR-2-like cd15302
muscarinic acetylcholine receptor GAR-2 and similar proteins, member of the class A family of ...
47-323 1.93e-04

muscarinic acetylcholine receptor GAR-2 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Muscarinic acetylcholine receptors (mAChRs) regulate the activity of many fundamental central and peripheral functions. The mAChR family consists of 5 subtypes M1-M5, which can be further divided into two major groups according to their G-protein coupling preference. The M1, M3 and M5 receptors selectively interact with G proteins of the G(q/11) family, whereas the M2 and M4 receptors preferentially link to the G(i/o) types of G proteins. Activation of mAChRs by agonist (acetylcholine) leads to a variety of biochemical and electrophysiological responses. In general, the exact nature of these responses and the subsequent physiological effects mainly depend on the molecular and pharmacological identity of the activated receptor subtype(s). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320429 [Multi-domain]  Cd Length: 266  Bit Score: 42.42  E-value: 1.93e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  47 LSFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWV-VLTIPVWVVSLVQHNQWPMGELTCKVTHLIFS 125
Cdd:cd15302   3 LALITAILSIITVIGNILVLLSFYVDRNIRQPSNYFIASLAVSDLLIgLESMPFYTVYVLNGDYWPLGWVLCDLWLSVDY 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 126 INLFGSIFFLTCMSVDRYLSITYFTNTPSSRKKmvRRVvcilVWLLAFCVSLPDTYYLKTVTSASNNETYCRSFYPEHSI 205
Cdd:cd15302  83 TVCLVSIYTVLLITIDRYCSVKIPAKYRNWRTP--RKV----LLIIAITWIIPALLFFISIFGWQYFTGQGRSLPEGECY 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 206 KEWLIGmELVSVVLGFAVPFSIIAVFyFLLARAISASSDQEKHSSRKIIFsYVVVFLVCWLPYHVAVLLDIFsilhyipf 285
Cdd:cd15302 157 VQFMTD-PYFNMGMYIGYYWTTLIVM-LILYAGIYRAANRARKALRTITF-ILGAFVICWTPYHILATIYGF-------- 225
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 31083344 286 tCRLEHALFTALH-VTQCLSLVHCCVNPVLYSFINRNYR 323
Cdd:cd15302 226 -CEAPPCVNETLYtISYYLCYMNSPINPFCYALANQQFK 263
7tmA_Adenosine_R_A2A cd15068
adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G ...
52-323 2.06e-04

adenosine receptor subtype A2A, member of the class A family of seven-transmembrane G protein-coupled receptors; The A2A receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand and is involved in regulating myocardial oxygen consumption and coronary blood flow. High-affinity A2A and low-affinity A2B receptors are preferentially coupled to G proteins of the stimulatory (Gs) family, which lead to activation of adenylate cyclase and thereby increasing the intracellular cAMP levels. The A2A receptor activation protects against tissue injury and acts as anti-inflammatory agent. In human skin endothelial cells, activation of A2B receptor, but not the A2A receptor, promotes angiogenesis. Alternatively, activated A2A receptor, but not the A2B receptor, promotes angiogenesis in human umbilical vein and lung microvascular endothelial cells. The A2A receptor alters cardiac contractility indirectly by modulating the anti-adrenergic effect of A1 receptor, while the A2B receptor exerts direct effects on cardiac contractile function, but does not modulate beta-adrenergic or A1 anti-adrenergic effects.


Pssm-ID: 320196 [Multi-domain]  Cd Length: 293  Bit Score: 42.62  E-value: 2.06e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  52 IFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWV-VLTIPVWVVslvqhnqwpMGELTCKVTHLIFSINLF- 129
Cdd:cd15068   8 LAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVgVLAIPFAIT---------ISTGFCAACHGCLFIACFv 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 130 -----GSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSL-PDTYYLKTVTSASNN--ETYCRS--- 198
Cdd:cd15068  79 lvltqSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLtPMLGWNNCGQPKEGKnhSQGCGEgqv 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 199 --FYPEHSIKEWLIGMELVSVVLgfaVPFSIIAVFY---FLLAR-------------AISASSDQEKHSSRKIIFSYVVV 260
Cdd:cd15068 159 acLFEDVVPMNYMVYFNFFACVL---VPLLLMLGVYlriFLAARrqlkqmesqplpgERARSTLQKEVHAAKSLAIIVGL 235
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 31083344 261 FLVCWLPYHVavlLDIFSIlhyipFTCRLEHALFTALHVTQCLSLVHCCVNPVLYSFINRNYR 323
Cdd:cd15068 236 FALCWLPLHI---INCFTF-----FCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFR 290
7tmA_Parapinopsin cd15075
non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled ...
46-323 2.42e-04

non-visual parapinopsin, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the non-visual pineal pigment, parapinopsin, which is a member of the class A of the seven transmembrane G protein-coupled receptors. Parapinopsin serves as a UV-sensitive pigment for the wavelength discrimination in the pineal-related organs of lower vertebrates such as reptiles, amphibians, and fish. Although parapinopsin is phylogenetically related to vertebrate visual pigments such as rhodopsin, which releases its retinal chromophore and bleaches, the parapinopsin photoproduct is stable and does not bleach. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extra-retinal tissues and/or in non-rod, non-cone retinal cells.


Pssm-ID: 320203 [Multi-domain]  Cd Length: 279  Bit Score: 42.46  E-value: 2.42e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  46 TLSFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVTHliFS 125
Cdd:cd15075   2 ILSIIMAVFSIASVVLNATVIIVTLRHKQLRQPLNYALVNLAVADLGTTVFGGLLSVVTNAVGYFNLGRVGCVLEG--FA 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 126 INLFG--SIFFLTCMSVDRYLSIT--YFTNTPSSRKKMVRRVVCilvWLLAFCVSLP-----DTYYLKTVTSASNNETYC 196
Cdd:cd15075  80 VAFFGiaALCTVAVIAVDRLFVVCkpLGTLTFQTRHALAGIASS---WLWSLIWNTPplfgwGSYQLEGVMTSCAPDWYS 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 197 RSFYPEHSIkewligmeLVSVVLGFAVPFSIIAVFY----------FLLARAISASSDQEKHSSRKIIFSYVVVFLVCWL 266
Cdd:cd15075 157 RDPVNVSYI--------LCYFSFCFAIPFAIILVSYgyllwtlrqvAKLGVAEGGSTAKAEVQVARMVVVMVMAFLLCWL 228
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 31083344 267 PYHVAVLLDIFSILHYI-PFTCRLEHALFTALHVtqclslvhccVNPVLYSFINRNYR 323
Cdd:cd15075 229 PYAAFALTVVSKPDVYInPLIATVPMYLAKSSTV----------YNPIIYIFMNKQFR 276
7tmA_V1aR cd15385
vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G ...
54-317 2.51e-04

vasopressin receptor subtype 1A, member of the class A family of seven-transmembrane G protein-coupled receptors; V1a-type receptor is a G(q/11)-coupled receptor that mediates blood vessel constriction. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320507 [Multi-domain]  Cd Length: 301  Bit Score: 42.50  E-value: 2.51e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  54 IFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWV----VLTIPVWVVSLVQHNQwpmgELTCKVTHLIFSINLF 129
Cdd:cd15385  10 IFAVAVIGNSSVLLALYKTKKKASRMHLFIKHLSLADLVVaffqVLPQLCWDITYRFYGP----DFLCRIVKHLQVLGMF 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 130 GSIFFLTCMSVDRYLSITYFTNTPSSRKKMvRRVVCILVWLLAFCVSLPDtyYLKTVTSASNNETYCRSFYPeHSIKEWL 209
Cdd:cd15385  86 ASTYMLVMMTADRYIAICHPLKTLQQPTKR-SYLMIGSAWALSFILSTPQ--YFIFSLSEIENGSGVYDCWA-NFIVPWG 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 210 IGMELVSVVLG-FAVPFSIIAVFY--------------------------FLLARAISA--SSDQEKHSSRKIIFSYVVV 260
Cdd:cd15385 162 IKAYITWITISiFVVPVIILLTCYgficyniwrnikcktrrglsdnalknILLAVCVSSvkTISRAKIRTVKMTFVIVLA 241
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 31083344 261 FLVCWLPYHVAVLLDIfsilhYIPFTCRLEhALFTALHVTQCLSLVHCCVNPVLYSF 317
Cdd:cd15385 242 YIVCWAPFFTIQMWSV-----WDQNFPWDE-SENTAVTITALLASLNSCCNPWIYMF 292
7tmA_SREB3_GPR173 cd15217
super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of ...
53-185 3.07e-04

super conserved receptor expressed in brain 3 (or GPR173), member of the class A family of seven-transmembrane G protein-coupled receptors; The SREB (super conserved receptor expressed in brain) subfamily consists of at least three members, named SREB1 (GPR27), SREB2 (GPR85), and SREB3 (GPR173). They are very highly conserved G protein-coupled receptors throughout vertebrate evolution, however no endogenous ligands have yet been identified. SREB2 is greatly expressed in brain regions involved in psychiatric disorders and cognition, such as the hippocampal dentate gyrus. Genetic studies in both humans and mice have shown that SREB2 influences brain size and negatively regulates hippocampal adult neurogenesis and neurogenesis-dependent cognitive function, all of which are suggesting a potential link between SREB2 and schizophrenia. All three SREB genes are highly expressed in differentiated hippocampal neural stem cells. Furthermore, all GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320345 [Multi-domain]  Cd Length: 329  Bit Score: 42.24  E-value: 3.07e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  53 FIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIAD-LWVVLTIPVWVVSLVQHNQWPMGELTCKVTHLIFSINLFGS 131
Cdd:cd15217   9 LIICVSLAGNLIVSLLVLKDRALHKAPYYFLLDLCLADtIRSAVCFPFVLVSIRNGSAWTYSVLSCKIVAFMAVLFCFHA 88
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 31083344 132 IFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDTYYLKT 185
Cdd:cd15217  89 AFMLFCISVTRYMAIAHHRFYSKRMTFWTCIAVICMVWTLSVAMAFPPVFDVGT 142
7tmA_V1bR cd15386
vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G ...
54-319 3.41e-04

vasopressin receptor subtype 1B, member of the class A family of seven-transmembrane G protein-coupled receptors; The V1b receptor is specifically expressed in corticotropes of the anterior pituitary and plays a critical role in regulating the activity of hypothalamic-pituitary-adrenal axis, a key part of the neuroendocrine system that controls reactions to stress, by maintaining adrenocorticotropic hormone (ACTH) and corticosterone levels. Vasopressin (also known as arginine vasopressin or anti-diuretic hormone) is synthesized in the hypothalamus and is released from the posterior pituitary gland. The actions of vasopressin are mediated by the interaction of this hormone with three receptor subtypes: V1aR, V1bR, and V2R. These subtypes are differ in localization, function, and signaling pathways. Activation of V1aR and V1bR stimulate phospholipase C, while activation of V2R stimulates adenylate cyclase. Although vasopressin and oxytocin differ only by two amino acids and stimulate the same cAMP/PKA pathway, they have divergent physiological functions. Vasopressin is involved in regulating blood pressure and the balance of water and sodium ions, whereas oxytocin plays an important role in the uterus during childbirth and in lactation.


Pssm-ID: 320508 [Multi-domain]  Cd Length: 302  Bit Score: 42.09  E-value: 3.41e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  54 IFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVL--TIPVWVVSLVQHNQWPmgELTCKVTHLIFSINLFGS 131
Cdd:cd15386  10 ILVVATAGNLAVLLAMYRMRRKMSRMHLFVLHLALTDLVVALfqVLPQLIWEITYRFQGP--DLLCRAVKYLQVLSMFAS 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 132 IFFLTCMSVDRYLSITYftntPSSRKKMVRRVVCILV---WLLAFCVSLPDTYY--LKTVTSASNNETYCRSFYPEHSIK 206
Cdd:cd15386  88 TYMLIMMTVDRYIAVCH----PLRTLQQPSRQAYLMIgatWLLSCILSLPQVFIfsLREVDQGSGVLDCWADFGFPWGAK 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 207 EWLIGMELVSvvlgFAVPFSIIAVFYFLLARAISASSDQEKHSSR-----------------------------KIIFSY 257
Cdd:cd15386 164 AYITWTTLSI----FVLPVAILIVCYSLICYEICKNLKGKTQTSRsegggwrtqgmpsrvssvrtisrakirtvKMTFVI 239
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 31083344 258 VVVFLVCWLPYHVAVLLDIFSIlhyipfTCRLEHALFTALHVTQCLSLVHCCVNPVLYSFIN 319
Cdd:cd15386 240 VLAYIACWAPFFSVQMWSVWDE------NAPDEDSSDFAFTITMLLASLSSCCNPWIYMFFS 295
7tmA_alpha2A_AR cd15322
alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G ...
46-323 4.75e-04

alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320445 [Multi-domain]  Cd Length: 259  Bit Score: 41.47  E-value: 4.75e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  46 TLSFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWV-VLTIPVWVVSLVQhNQWPMGELTCKVTHLIF 124
Cdd:cd15322   2 TLIILVGLLMLLTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVaTLVIPFSLANEVM-GYWYFGKVWCEIYLALD 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 125 SINLFGSIFFLTCMSVDRYLSITyfTNTPSSRKKMVRRVVCIL--VWLLAFCVSLPDTYYLKTvTSASNNETYCrsfypE 202
Cdd:cd15322  81 VLFCTSSIVHLCAISLDRYWSIT--QAIEYNLKRTPRRIKCIIfiVWVISAVISFPPLITIEK-KSGQPEGPIC-----K 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 203 HSIKEWLIgmeLVSVVLGFAVPFSIIAVFYFllaRAISASSDQEKHSSrkIIFSYVV-VFLVCWLPYHVAVLLDIFSilh 281
Cdd:cd15322 153 INDEKWYI---ISSCIGSFFAPCLIMVLVYI---RIYQIAKNREKRFT--FVLAVVIgVFVICWFPFFFTYTLTAVC--- 221
                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 31083344 282 yipfTCRLEHALFTALHvtqCLSLVHCCVNPVLYSFINRNYR 323
Cdd:cd15322 222 ----DCSVPETLFKFFF---WFGYCNSSLNPVIYTIFNHDFR 256
7tmA_MrgprF cd15109
mas-related G protein-coupled receptor subtype F, member of the class A family of ...
47-182 6.16e-04

mas-related G protein-coupled receptor subtype F, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined.


Pssm-ID: 320237  Cd Length: 274  Bit Score: 41.05  E-value: 6.16e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  47 LSFIYIFIFVIGMIANSVVVWV-NIQAKTTGYDThcYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVTHLIFS 125
Cdd:cd15109   3 MNYIFLLLCLCGLVGNGLVLWFfGFSIKRNPFSI--YFLHLASADVGYLFSKAVFSILNTGGFLGTFADYIRSVSRILGL 80
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 31083344 126 INLFGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDTYY 182
Cdd:cd15109  81 CTFLTGVSLLPAISIERCVSVIFPTWYWRRRPKRLSAVVCALLWMLSLLVTCIHNYF 137
7tmA_SWS1_opsin cd15076
short wave-sensitive 1 opsins, member of the class A family of seven-transmembrane G ...
53-323 6.18e-04

short wave-sensitive 1 opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Short Wave-Sensitive opsin 1 (SWS1), which mediates visual transduction in response to light at short wavelengths (ultraviolet to blue). Vertebrate cone opsins are expressed in cone photoreceptor cells of the retina and involved in mediating photopic vision, which allows color perception. The cone opsins can be classified into four classes according to their peak absorption wavelengths: SWS1 (ultraviolet sensitive), SWS2 (short wave-sensitive), MWS/LWS (medium/long wave-sensitive), and RH2 (medium wave-sensitive, rhodopsin-like opsins). Members of this group belong to the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320204 [Multi-domain]  Cd Length: 280  Bit Score: 40.96  E-value: 6.18e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  53 FIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIAD-LWVVLTI-PVWVVSLvqHNQWPMGELTCKVTHLIFSINLFG 130
Cdd:cd15076   9 FVFIVGTPLNAIVLFVTIKYKKLRQPLNYILVNISLAGfIFCIFSVfPVFVASA--QGYFFFGRTVCALEAFVGSLAGLV 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 131 SIFFLTCMSVDRYLSITY-FTNTPSSRKKMVRRVVCilVWLLAFCVSLP-----DTYYLKTVTSASNNETYCRSFYPEHS 204
Cdd:cd15076  87 TGWSLAFLAFERYIVICKpFGNFRFGSKHALGAVVA--TWIIGIGVSLPpffgwSRYIPEGLQCSCGPDWYTVGTKYRSE 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 205 IKEWLIgmelvsVVLGFAVPFSIIAVFYFLLARAISASSDQEKHS----------SRKIIFsYVVVFLVCWLPYHVAVLL 274
Cdd:cd15076 165 YYTWFL------FIFCFIVPLSIIIFSYSQLLGALRAVAAQQQESastqkaerevSRMVVV-MVGSFCLCYVPYAALAMY 237
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 31083344 275 DIFSILHYIPFTCRLEHALFtalhvtqclSLVHCCVNPVLYSFINRNYR 323
Cdd:cd15076 238 MVNNRDHGLDLRLVTIPAFF---------SKSSCVYNPIIYCFMNKQFR 277
7tmA_MrgprX-like cd15106
primate-specific mas-related G protein-coupled receptor subtype X-like, member of the class A ...
46-318 7.10e-04

primate-specific mas-related G protein-coupled receptor subtype X-like, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined.


Pssm-ID: 320234  Cd Length: 274  Bit Score: 40.89  E-value: 7.10e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  46 TLSFIYIFIFVIGMIANSVVVWVnIQAKTTGYDTHCYILNLAIADLWV----VLTIPVWVVSLVQHNQWPmgeltcKVTH 121
Cdd:cd15106   2 SLTFLTCIISLVGLTGNAVVLWL-LGFRMRRNAFSVYILNLAAADFLFlcchIIDSLLRLINIFHIISIP------KILT 74
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 122 LIFSINLFGSIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSLPDTYYLKTVTSASNNeTYCRSFyp 201
Cdd:cd15106  75 NVMTFPYFAGLSMLSAISTERCLSVLWPIWYRCHRPRHLSAVVCVLLWALSLLLSILEWKFCGFLFSGADS-HWCQTF-- 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 202 EHSIKEWLIGMELVSVVLGFAvpfsiiavfyfLLARAISASSDQEKHSSRKIIFSYVVVFLVCWLPYHVavlldIFSILH 281
Cdd:cd15106 152 DFITTAWLIFLFVVLCGSSLA-----------LLVRILCGSRKMPLTRLYVTILLTVLVFLLCGLPFGI-----QWFLLL 215
                       250       260       270
                ....*....|....*....|....*....|....*...
gi 31083344 282 YIPFTCrleHALFTALH-VTQCLSLVHCCVNPVLYSFI 318
Cdd:cd15106 216 WIHIDL---EVLFCHVYlVSVVLSCLNSSANPIIYFFV 250
7tmA_Adenosine_R_A3 cd15070
adenosine receptor subtype A3, member of the class A family of seven-transmembrane G ...
50-270 7.13e-04

adenosine receptor subtype A3, member of the class A family of seven-transmembrane G protein-coupled receptors; The A3 receptor, a member of the adenosine receptor family of G protein-coupled receptors, is coupled to G proteins of the inhibitory G(i) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels. The A3 receptor has a sustained protective function in the heart during cardiac ischemia and contributes to inhibition of neutrophil degranulation in neutrophil-mediated tissue injury. Moreover, activation of A3 receptor by adenosine protects astrocytes from cell death induced by hypoxia.


Pssm-ID: 320198 [Multi-domain]  Cd Length: 280  Bit Score: 40.92  E-value: 7.13e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  50 IYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWV-VLTIPVWVVSLVQHNqwpMGELTCKVTHLIFSINL 128
Cdd:cd15070   6 IEILIGLCAVVGNVLVIWVVKLNPSLRTTTFYFIVSLALADIAVgVLVIPLAIVVSLGVT---IHFYSCLFMSCLLVVFT 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 129 FGSIFFLTCMSVDRYL--SITYFTNTPSSRKKMVRRVVciLVWLLAFCVSL-PDTYYLKTVTSASNNETYCRSFYPEHSI 205
Cdd:cd15070  83 HASIMSLLAIAVDRYLrvKLTVRYRIVTTQRRIWLALG--LCWLVSFLVGLtPMFGWNRKPSLESVNTTPLQCQFTSVMR 160
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 31083344 206 KEWLIGMELVSVVLgfaVPFSIIAVFYFLLARAISASSDQEKHSSR-------------KIIFSYVVVFLVCWLPYHV 270
Cdd:cd15070 161 MDYMVYFSFFTWIL---IPLVIMCALYVDIFYIIRNKLSQNATGFRetgafygrefktaKSLALVLFLFAVCWLPLSI 235
7tmA_alpha-2D_AR cd15324
alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G ...
54-323 1.23e-03

alpha-2 adrenergic receptors subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The alpha-2 adrenergic receptors (or adrenoceptors) are a subfamily of the class A rhodopsin-like GPCRs that share a common architecture of seven transmembrane helices. This subfamily consists of three highly homologous receptor subtypes that have a key role in neurotransmitter release: alpha-2A, alpha-2B, and alpha-2C. In addition, a fourth subtype, alpha-2D is present in ray-finned fishes and amphibians, but is not found in humans. The alpha-2 receptors are found in both central and peripheral nervous system and serve to produce inhibitory functions through the G(i) proteins. Thus, the alpha-2 receptors inhibit adenylate cyclase, which decreases cAMP production and thereby decreases calcium influx during the action potential. Consequently, lowered levels of calcium will lead to a decrease in neurotransmitter release by negative feedback.


Pssm-ID: 320447 [Multi-domain]  Cd Length: 256  Bit Score: 40.24  E-value: 1.23e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  54 IFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWV-VLTIPVWVVSLVQhNQWPMGELTCKVTHLIFSINLFGSI 132
Cdd:cd15324  10 IILVTIVGNVLVVVAVFTSRALRAPQNLFLVSLASADILVaTLVIPFSLANEVM-GYWYFGSTWCAFYLALDVLFCTSSI 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 133 FFLTCMSVDRYLSITyfTNTPSSRKKMVRRVVCIL--VWLLAFCVSLPDTYYLKtvtsasnnetycrsfypeHSIKEWLI 210
Cdd:cd15324  89 VHLCAISLDRYWSVT--KAVSYNLKRTPKRIKRMIavVWVISAVISFPPLLMTK------------------HDEWECLL 148
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 211 GME----LVSVVLGFAVPFSIIAVFYFLLARAisassdqEKHSSRKIIFSYVVV---FLVCWLPYHVAvlldiFSILHYI 283
Cdd:cd15324 149 NDEtwyiLSSCTVSFFAPGLIMILVYCKIYRV-------AKMREKRFTFVLAVVmgvFVLCWFPFFFT-----YSLHAVC 216
                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 31083344 284 PFTCRLEHALFTALHvtqCLSLVHCCVNPVLYSFINRNYR 323
Cdd:cd15324 217 RKRCGIPDALFNLFF---WIGYCNSSVNPIIYTIFNRDFR 253
7tmA_Beta2_AR cd15957
beta-2 adrenergic receptors (adrenoceptors), member of the class A family of ...
79-176 1.48e-03

beta-2 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; Beta-2 AR is activated by adrenaline that plays important roles in cardiac function and pulmonary physiology. While beta-1 AR and beta-2 AR are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway, beta-2 AR can couple to both G(s) and G(i) proteins in the heart. Moreover, beta-2 AR activation leads to smooth muscle relaxation and bronchodilation in the lung. The beta adrenergic receptors are a subfamily of the class A rhodopsin-like G protein-coupled receptors.


Pssm-ID: 341355 [Multi-domain]  Cd Length: 301  Bit Score: 39.85  E-value: 1.48e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  79 THCYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVTHLIFSINLFGSIFFLTCMSVDRYLSITYFTNTPSSRKK 158
Cdd:cd15957  35 TNYFITSLACADLVMGLAVVPFGAAHILLKTWTFGNFWCEFWTSIDVLCVTASIETLCVIAVDRYFAITSPFKYQSLLTK 114
                        90
                ....*....|....*...
gi 31083344 159 MVRRVVCILVWLLAFCVS 176
Cdd:cd15957 115 NKARVIILMVWIVSGLTS 132
7tmA_Adenosine_R_A1 cd15071
adenosine receptor subtype A1, member of the class A family of seven-transmembrane G ...
50-323 1.80e-03

adenosine receptor subtype A1, member of the class A family of seven-transmembrane G protein-coupled receptors; The adenosine A1 receptor, a member of the adenosine receptor family of G protein-coupled receptors, binds adenosine as its endogenous ligand. The A1 receptor has primarily inhibitory function on the tissues in which it is located. The A1 receptor slows metabolic activity in the brain and has a strong anti-adrenergic effects in the heart. Thus, it antagonizes beta1-adrenergic receptor-induced stimulation and thereby reduces cardiac contractility. The A1 receptor preferentially couples to G proteins of the G(i/o) family, which lead to inhibition of adenylate cyclase and thereby lowering the intracellular cAMP levels.


Pssm-ID: 341323 [Multi-domain]  Cd Length: 290  Bit Score: 39.83  E-value: 1.80e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  50 IYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWV-VLTIPVWVVSlvqhNQWPMGEL-TCKVTHLIFSIN 127
Cdd:cd15071   6 IEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVgALVIPLAIII----NIGPQTEFySCLMVACPVLIL 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 128 LFGSIFFLTCMSVDRYLSItyftNTPSSRKKMV--RR--VVCILVWLLAFCVSLPDTYYLKTVTSASNNETyCRSFYPEH 203
Cdd:cd15071  82 TQSSILALLAIAVDRYLRV----KIPTRYKSVVtpRRaaVAIAGCWILSFLVGLTPMFGWNNLNAVERAWA-ANSSMGEL 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 204 SIK---EWLIGMELVsVVLGFAV----PFSIIAVFYF---------LLARAISASSDQEKHSSR--KIIFSYVVV---FL 262
Cdd:cd15071 157 VIKcqfETVISMEYM-VYFNFFVwvlpPLLLMLLIYLevfylirkqLNKKVSSSSSDPQKYYGKelKIAKSLALIlflFA 235
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 31083344 263 VCWLPYHvavlldifsILHYIPFTCRLEHALFTALHVTQCLSLVHCCVNPVLYSFINRNYR 323
Cdd:cd15071 236 LSWLPLH---------ILNCITLFCPSCKKPMILTYIAIFLTHGNSAMNPIVYAFRIKKFR 287
7tmA_Ap5-HTB1-like cd15065
serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of ...
42-323 1.90e-03

serotonin receptor subtypes B1 and B2 from Aplysia californica and similar proteins; member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes Aplysia californica serotonin receptors Ap5-HTB1 and Ap5-HTB2, and similar proteins from bilateria including insects, mollusks, annelids, and worms. Ap5-HTB1 is one of the several different receptors for 5-hydroxytryptamine (5HT, serotonin). In Aplysia, serotonin plays important roles in a variety of behavioral and physiological processes mediated by the central nervous system. These include circadian clock, feeding, locomotor movement, cognition and memory, synaptic growth and synaptic plasticity. Both Ap5-HTB1 and Ap5-HTB2 receptors are coupled to G-proteins that stimulate phospholipase C, leading to the activation of phosphoinositide metabolism. Ap5-HTB1 is expressed in the reproductive system, whereas Ap5-HTB2 is expressed in the central nervous system.


Pssm-ID: 320193 [Multi-domain]  Cd Length: 300  Bit Score: 39.64  E-value: 1.90e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  42 VLLYTLSFIyIFIFVIGMIANSVVVWVNIQAKTTGYdthCYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVTH 121
Cdd:cd15065   1 LIGIFLSLI-IVLAIFGNVLVCLAIFTDRRLRKKSN---LFIVSLAVADLLVALLVMTFAVVNDLLGYWLFGETFCNIWI 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 122 LIFSINLFGSIFFLTCMSVDRYLSIT--YFTNTPSSRKKMVrrVVCILVWLLAFCVSL---------PDTYYLKTVTSAS 190
Cdd:cd15065  77 SFDVMCSTASILNLCAISLDRYIHIKkpLKYERWMTTRRAL--VVIASVWILSALISFlpihlgwhrLSQDEIKGLNHAS 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 191 NNETYCR-SFYPEHSIkewligmelVSVVLGFAVPFSIIAVFY---FLLAR------------AISASSDQEKHSSRK-- 252
Cdd:cd15065 155 NPKPSCAlDLNPTYAV---------VSSLISFYIPCLVMLLIYsrlYLYARkhvvniksqklpSESGSKFQVPSLSSKhn 225
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 253 --------------IIFSyvvVFLVCWLPYhvaVLLDIFSIL--HYIPFTCrlehalftaLHVTQCLSLVHCCVNPVLYS 316
Cdd:cd15065 226 nqgvsdhkaavtlgIIMG---VFLICWLPF---FIINIIAAFckTCIPPKC---------FKILTWLGYFNSCLNPIIYS 290

                ....*..
gi 31083344 317 FINRNYR 323
Cdd:cd15065 291 IFNSEFR 297
7tmA_PGE2_EP4 cd15142
prostaglandin E2 receptor EP4 subtype, member of the class A family of seven-transmembrane G ...
50-277 2.15e-03

prostaglandin E2 receptor EP4 subtype, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin E2 receptor EP4, also called prostanoid EP4 receptor, is one of four receptor subtypes whose endogenous physiological ligand is prostaglandin E2 (PGE2). Each of these subtypes (EP1-EP4) have unique but overlapping tissue distributions that activate different intracellular signaling pathways. Like the EP2 receptor, stimulation of the EP4 receptor by PGE2 causes cAMP accumulation through G(s) protein activation. Knockout studies in mice suggest that EP4 receptor may be involved in the maintenance of bone mass and fracture healing. Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320270 [Multi-domain]  Cd Length: 302  Bit Score: 39.41  E-value: 2.15e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  50 IYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYIL--NLAIADLW-VVLTIPVWVVSLVQhNQWPMGELTCKvtHLIFSI 126
Cdd:cd15142   6 IPAVMFIFGVVGNLIAIVVLCKSRKEQKETTFYTLvcGLAVTDLLgTCLASPVTIATYLK-GRWPGGQPLCE--YFSFIL 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 127 NLFGS--IFFLTCMSVDRYLSIT--YFTNTPSSRKKMVRRVVCILVWLLAFCVsLPDTYYLKTVTSASnnETYC----RS 198
Cdd:cd15142  83 LFFSLsgLSIICAMSIERYLAINhaYFYNHYVDKRLAGLTLFAIYASNILFCA-LPSMGLGKSKLQYP--KTWCfidwRT 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 199 FYPEHSIKEWLIG-----MELVSVVLGFAVPFSIIAVFYFLLARAISASSDQEKHSSRKIIFSYV--------------- 258
Cdd:cd15142 160 NVSVHAAYSYMYAgfsslLILVTVLCNVLVCGALIRMHRQFVRRTSLGTDQRLSDFRRRRSFRRMagaeiqmvilliats 239
                       250
                ....*....|....*....
gi 31083344 259 VVFLVCWLPYHVAVLLDIF 277
Cdd:cd15142 240 VVVLICSIPLVVRVFVNQL 258
7tmA_Beta3_AR cd15959
beta-3 adrenergic receptors (adrenoceptors), member of the class A family of ...
54-177 3.10e-03

beta-3 adrenergic receptors (adrenoceptors), member of the class A family of seven-transmembrane G protein-coupled receptors; The beta-3 adrenergic receptor (beta-3 adrenoceptor), also known as beta-3 AR, is activated by adrenaline and plays important roles in regulating cardiac function and heart rate. The human heart contains three subtypes of the beta AR: beta-1 AR, beta-2 AR, and beta-3 AR. Beta-1 AR and beta-2 AR, which expressed at about a ratio of 70:30, are the major subtypes involved in modulating cardiac contractility and heart rate by positively stimulating the G(s) protein-adenylate cyclase-cAMP-PKA signaling pathway. In contrast, beta-3 AR produces negative inotropic effects by activating inhibitory G(i) proteins. The aberrant expression of betrayers can lead to cardiac dysfunction such as arrhythmias or heart failure.


Pssm-ID: 320625 [Multi-domain]  Cd Length: 302  Bit Score: 39.12  E-value: 3.10e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  54 IFVIGMIANSVVVWVNIqAKTTGYDT--HCYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVTHLIFSINLFGS 131
Cdd:cd15959   9 LAILVIVGGNLLVIVAI-AKTPRLQTmtNVFVTSLACADLVMGLLVVPPGATILLTGHWPLGTTVCELWTSVDVLCVTAS 87
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 31083344 132 IFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVCILVWLLAFCVSL 177
Cdd:cd15959  88 IETLCAIAVDRYLAITNPLRYEALVTKRRARTAVCLVWAISAAISF 133
7tmA_DmOct-betaAR-like cd15066
Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar ...
79-323 4.05e-03

Drosophila melanogaster beta-adrenergic receptor-like octopamine receptors and similar receptors in bilateria; member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila beta-adrenergic-like octopamine receptors and similar proteins. The biogenic amine octopamine is the invertebrate equivalent of vertebrate adrenergic neurotransmitters and exerts its effects through different G protein-coupled receptor types. Insect octopamine receptors are involved in the modulation of carbohydrate metabolism, muscular tension, cognition and memory. The activation of octopamine receptors mediating these actions leads to an increase in adenylate cyclase activity, thereby increasing cAMP levels. In Drosophila melanogaster, three subgroups have been classified on the basis of their structural homology and functional equivalents with vertebrate beta-adrenergic receptors: DmOctBeta1R, DmOctBeta2R, and DmOctBeta3R.


Pssm-ID: 320194 [Multi-domain]  Cd Length: 265  Bit Score: 38.51  E-value: 4.05e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  79 THCYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGELTCKVTH---LIFSInlfGSIFFLTCMSVDRYLSITYFTNTPSs 155
Cdd:cd15066  34 TNYFVVSLAMADMLVALCAMTFNASVEITGRWMFGYFMCDVWNsldVYFST---ASILHLCCISVDRYYAIVQPLEYPS- 109
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 156 rkKMVRRVVCIL---VWLLAFCVS-LPdtYYLKTVTSASNNETycRSFYPEHSIKEWLIGMELVSVVLGFAVPfSIIAVF 231
Cdd:cd15066 110 --KMTKRRVAIMlanVWISPALISfLP--IFLGWYTTEEHLQY--RKTHPDQCEFVVNKIYALISSSVSFWIP-CIVMIF 182
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 232 YFLlarAISASSDQEKHSSRK--IIFSyvvVFLVCWLPyhvavlldiFSILHYIPFTCR--------LEHALFTALHVTQ 301
Cdd:cd15066 183 TYY---RIYLEAKREHKAAKTlgIIMG---AFILCWLP---------FFLWYVTTTLCGdacpyppiLVSILFWIGYFNS 247
                       250       260
                ....*....|....*....|..
gi 31083344 302 CLslvhccvNPVLYSFINRNYR 323
Cdd:cd15066 248 TL-------NPLIYAYFNRDFR 262
7tmA_ACKR1_DARC cd15010
Duffy antigen receptor for chemokines, member of the class A family of seven-transmembrane G ...
260-314 4.13e-03

Duffy antigen receptor for chemokines, member of the class A family of seven-transmembrane G protein-coupled receptors; Atypical chemokine receptor 1 (ACKR1), also known as DARC (Duffy antigen receptor for chemokines) or Fy glycoprotein (GpFy), was originally identified on erythrocytes. ACKR1 is also ubiquitously expressed by endothelial cells of venules and is highly promiscuous among all chemokine receptor. It binds many proinflammatory chemokines from both the CC and CXC subfamilies, including CCL2, CCL5, CCL7, CCL11, CXCL1, CXCL2, CXCL3, and CXCL5. Erythrocyte ACKR1 is thought to act as a chemokine sink, limiting the levels of circulating chemokines, thereby controlling leukocyte activation. ACKR1-deficient erythrocytes are shown to confer resistance to the malarial parasite, Plasmodium vivax. On the other hand, ACKR1-expressing endothelial cells can internalize chemokines. ACKR1-internalized chemokines can be moved intact across the endothelium and promotes neutrophil transmigration. Unlike the classical chemokine receptors that contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-Chemokine Receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, DARC, and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 410631  Cd Length: 257  Bit Score: 38.62  E-value: 4.13e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 31083344 260 VFLVCWLPYHVAVLLDifSILH---YIPFTCRLEHALFTALHVTQCLSLVHCCVNPVL 314
Cdd:cd15010 189 LWFIFWWPYGVVLGLD--FLVRsklLLLSTCGAQEALDYMLGLSEALGILHCVATPLL 244
7tmA_VA_opsin cd15082
non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane ...
38-324 7.79e-03

non-visual VA (vertebrate ancient) opsins, member of the class A family of seven-transmembrane G protein-coupled receptors; The vertebrate ancient (VA) opsin photopigments were originally identified in salmon and they appear to have diverged early in the evolution of vertebrate opsins. VA opsins are localized in the inner retina and the brain in teleosts. The vertebrate non-visual opsin family includes pinopsins, parapinopsin, VA (vertebrate ancient) opsins, and parietopsins. These non-visual opsins are expressed in various extraretinal tissues and/or in non-rod, non-cone retinal cells. They are thought to be involved in light-dependent physiological functions such as photo-entrainment of circadian rhythm, photoperiodicity, and body color change. The VA opsins belong the class A of the G protein-coupled receptors and possess seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops.


Pssm-ID: 320210 [Multi-domain]  Cd Length: 291  Bit Score: 37.85  E-value: 7.79e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344  38 PNKSVLLYTLSFIYIFIFVIGMIA---NSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVLTIPVWVVSLVQHNQWPMGE 114
Cdd:cd15082   4 PLKSIAPWNFTVLAALMFVVTSLSlaeNFAVMLVTFRFKQLRQPLNYIIVNLSVADFLVSLTGGTISFLTNARGYFFLGV 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 115 LTCKVTHliFSINLFG--SIFFLTCMSVDRYLSITYFTNTPSSRKKMVRRVVcILVWLLAFCVSLPDTYYLKTVTSASNN 192
Cdd:cd15082  84 WACVLEG--FAVTFFGivALWSLAVLAFERFFVICRPLGNIRLQGKHAALGL-LFVWTFSFIWTIPPVLGWSSYTVSKIG 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31083344 193 ETYCRSFYPEHSIKEWLIGMELVSVvlgFAVPFSIIAVFYFLLARAISASSDQEKH--SSRK-------IIFSYVVVFLV 263
Cdd:cd15082 161 TTCEPNWYSGNMHDHTYIITFFTTC---FILPLGVIFVSYGKLLQKLRKVSNTQGRlgNARKperqvtrMVVVMIVAFMV 237
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 31083344 264 CWLPYHVavlldiFSILHYIPFTCRLEHALFTalhVTQCLSLVHCCVNPVLYSFINRNYRY 324
Cdd:cd15082 238 CWTPYAA------FSILVTAHPTIHLDPRLAA---IPAFFSKTAAVYNPIIYVFMNKQFRK 289
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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