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Conserved domains on  [gi|1653961044|ref|NP_064515|]
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transcriptional and immune response regulator [Homo sapiens]

Protein Classification

TC1 domain-containing protein( domain architecture ID 10633375)

TC1 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TC1 pfam15063
Thyroid cancer protein 1; Thyroid cancer protein 1 (TC1) is thought to decrease in apoptosis ...
 12-85 2.59e-34

Thyroid cancer protein 1; Thyroid cancer protein 1 (TC1) is thought to decrease in apoptosis and increase cell proliferation. It is found to be expressed in thyroid papillary carcinoma. This suggests its importance in thyroid cancer. The molecular mechanism of TC1, involves up-regulating cell signalling through ERK-1/2 signalling pathway and it positively regulates transition between the G1 and S phase in the cell cycle. It is thought to positively regulate Wnt/beta-catenin signalling pathway by interacting with its repressor. In humans, it is located in the chromosomal position, C8orf4. This family of proteins is found in eukaryotes and contains a conserved NIF sequence motif.


:

Pssm-ID: 464478  Cd Length: 75  Bit Score: 112.95  E-value: 2.59e-34
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1653961044  12 MSTSLRVSPSIHGYHFDTASRKKAVGNIFENTDQESLERLFRNSGDKKAEERAKIIFAiDQDVEEKTRALMALK 85
Cdd:pfam15063   3 SSASVRVSPSVHGRLFDTRSRKAASPNIFEDVNLDQLQRLFRKSGDQKAEERAQIIWG-HQDPEELARALMALR 75
 
Name Accession Description Interval E-value
TC1 pfam15063
Thyroid cancer protein 1; Thyroid cancer protein 1 (TC1) is thought to decrease in apoptosis ...
 12-85 2.59e-34

Thyroid cancer protein 1; Thyroid cancer protein 1 (TC1) is thought to decrease in apoptosis and increase cell proliferation. It is found to be expressed in thyroid papillary carcinoma. This suggests its importance in thyroid cancer. The molecular mechanism of TC1, involves up-regulating cell signalling through ERK-1/2 signalling pathway and it positively regulates transition between the G1 and S phase in the cell cycle. It is thought to positively regulate Wnt/beta-catenin signalling pathway by interacting with its repressor. In humans, it is located in the chromosomal position, C8orf4. This family of proteins is found in eukaryotes and contains a conserved NIF sequence motif.


Pssm-ID: 464478  Cd Length: 75  Bit Score: 112.95  E-value: 2.59e-34
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1653961044  12 MSTSLRVSPSIHGYHFDTASRKKAVGNIFENTDQESLERLFRNSGDKKAEERAKIIFAiDQDVEEKTRALMALK 85
Cdd:pfam15063   3 SSASVRVSPSVHGRLFDTRSRKAASPNIFEDVNLDQLQRLFRKSGDQKAEERAQIIWG-HQDPEELARALMALR 75
 
Name Accession Description Interval E-value
TC1 pfam15063
Thyroid cancer protein 1; Thyroid cancer protein 1 (TC1) is thought to decrease in apoptosis ...
 12-85 2.59e-34

Thyroid cancer protein 1; Thyroid cancer protein 1 (TC1) is thought to decrease in apoptosis and increase cell proliferation. It is found to be expressed in thyroid papillary carcinoma. This suggests its importance in thyroid cancer. The molecular mechanism of TC1, involves up-regulating cell signalling through ERK-1/2 signalling pathway and it positively regulates transition between the G1 and S phase in the cell cycle. It is thought to positively regulate Wnt/beta-catenin signalling pathway by interacting with its repressor. In humans, it is located in the chromosomal position, C8orf4. This family of proteins is found in eukaryotes and contains a conserved NIF sequence motif.


Pssm-ID: 464478  Cd Length: 75  Bit Score: 112.95  E-value: 2.59e-34
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1653961044  12 MSTSLRVSPSIHGYHFDTASRKKAVGNIFENTDQESLERLFRNSGDKKAEERAKIIFAiDQDVEEKTRALMALK 85
Cdd:pfam15063   3 SSASVRVSPSVHGRLFDTRSRKAASPNIFEDVNLDQLQRLFRKSGDQKAEERAQIIWG-HQDPEELARALMALR 75
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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