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Conserved domains on  [gi|9955931|ref|NP_064493|]
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acrosomal protein SP-10 isoform d precursor [Homo sapiens]

Protein Classification

Ly-6/uPAR domain-containing protein( domain architecture ID 10061478)

LU (Ly-6 antigen/uPA receptor-like) domain-containing protein similar to GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TFP_LU_ECD_SP10_like cd23628
extracellular domain (ECD) found in acrosomal protein SP-10, prostate and testis expressed ...
 117-194 1.87e-39

extracellular domain (ECD) found in acrosomal protein SP-10, prostate and testis expressed protein 14 (Pate14) and similar proteins; The family includes SP-10 and Pate14. SP-10 (also called acrosomal vesicle protein 1 (ACRV1)) is a human intra-acrosomal protein that is first detected in the developing acrosome of round spermatids and is observed associated with the acrosomal membranes and matrix of mature sperm. Pate14 ( also called prostate and testis expressed 14, or secreted seminal-vesicle Ly-6 protein 1 (SSLP-1)) is a secreted Ly-6 protein purified from mouse seminal vesicle fluid. Members in this family contain an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


:

Pssm-ID: 467148  Cd Length: 79  Bit Score: 129.72  E-value: 1.87e-39
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 9955931  117 ILNCYTCAYMNDQGKCLRGEGTCITQNSQQCMLKKIFEGGKLQFMVQGCENMCPSMNLFSHGTRMQIICCRNQSFCNK 194
Cdd:cd23628   2 ALTCFQCDRMNSDGICETGEGTCEAQNSQQCMLKKIFEGGKLQYGVQGCSNLCPNMTLFSGNTRVEITCCRNQSFCNK 79
CobT2 super family cl34772
Cobalamin biosynthesis cobaltochelatase CobT subunit [Coenzyme transport and metabolism]; ...
 24-115 7.61e-03

Cobalamin biosynthesis cobaltochelatase CobT subunit [Coenzyme transport and metabolism]; Cobalamin biosynthesis cobaltochelatase CobT subunit is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


The actual alignment was detected with superfamily member COG4547:

Pssm-ID: 443611 [Multi-domain]  Cd Length: 608  Bit Score: 36.70  E-value: 7.61e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9955931   24 NELSGSIDHQTSVQQL-------------PGEQPSGEQPSGEHLSGEQPLSELESGEQPSDEQPSGEHGSGEQPSGEQAS 90
Cdd:COG4547 182 DRLAELLDDQAAFARAvrdllrdldlaeeLGEDEDEEDEDDEDDSGEQEEDEEDGEDEDEESDEGAEAEDAEASGDDAEE 261

                        90       100
                ....*....|....*....|....*
gi 9955931   91 GEQPSGEHASGEQASGAPISSTSTG 115
Cdd:COG4547 262 GESEAAEAESDEMAEEAEGEDSEEP 286
 
Name Accession Description Interval E-value
TFP_LU_ECD_SP10_like cd23628
extracellular domain (ECD) found in acrosomal protein SP-10, prostate and testis expressed ...
 117-194 1.87e-39

extracellular domain (ECD) found in acrosomal protein SP-10, prostate and testis expressed protein 14 (Pate14) and similar proteins; The family includes SP-10 and Pate14. SP-10 (also called acrosomal vesicle protein 1 (ACRV1)) is a human intra-acrosomal protein that is first detected in the developing acrosome of round spermatids and is observed associated with the acrosomal membranes and matrix of mature sperm. Pate14 ( also called prostate and testis expressed 14, or secreted seminal-vesicle Ly-6 protein 1 (SSLP-1)) is a secreted Ly-6 protein purified from mouse seminal vesicle fluid. Members in this family contain an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467148  Cd Length: 79  Bit Score: 129.72  E-value: 1.87e-39
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 9955931  117 ILNCYTCAYMNDQGKCLRGEGTCITQNSQQCMLKKIFEGGKLQFMVQGCENMCPSMNLFSHGTRMQIICCRNQSFCNK 194
Cdd:cd23628   2 ALTCFQCDRMNSDGICETGEGTCEAQNSQQCMLKKIFEGGKLQYGVQGCSNLCPNMTLFSGNTRVEITCCRNQSFCNK 79
CobT2 COG4547
Cobalamin biosynthesis cobaltochelatase CobT subunit [Coenzyme transport and metabolism]; ...
 24-115 7.61e-03

Cobalamin biosynthesis cobaltochelatase CobT subunit [Coenzyme transport and metabolism]; Cobalamin biosynthesis cobaltochelatase CobT subunit is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 443611 [Multi-domain]  Cd Length: 608  Bit Score: 36.70  E-value: 7.61e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9955931   24 NELSGSIDHQTSVQQL-------------PGEQPSGEQPSGEHLSGEQPLSELESGEQPSDEQPSGEHGSGEQPSGEQAS 90
Cdd:COG4547 182 DRLAELLDDQAAFARAvrdllrdldlaeeLGEDEDEEDEDDEDDSGEQEEDEEDGEDEDEESDEGAEAEDAEASGDDAEE 261

                        90       100
                ....*....|....*....|....*
gi 9955931   91 GEQPSGEHASGEQASGAPISSTSTG 115
Cdd:COG4547 262 GESEAAEAESDEMAEEAEGEDSEEP 286
 
Name Accession Description Interval E-value
TFP_LU_ECD_SP10_like cd23628
extracellular domain (ECD) found in acrosomal protein SP-10, prostate and testis expressed ...
 117-194 1.87e-39

extracellular domain (ECD) found in acrosomal protein SP-10, prostate and testis expressed protein 14 (Pate14) and similar proteins; The family includes SP-10 and Pate14. SP-10 (also called acrosomal vesicle protein 1 (ACRV1)) is a human intra-acrosomal protein that is first detected in the developing acrosome of round spermatids and is observed associated with the acrosomal membranes and matrix of mature sperm. Pate14 ( also called prostate and testis expressed 14, or secreted seminal-vesicle Ly-6 protein 1 (SSLP-1)) is a secreted Ly-6 protein purified from mouse seminal vesicle fluid. Members in this family contain an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467148  Cd Length: 79  Bit Score: 129.72  E-value: 1.87e-39
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 9955931  117 ILNCYTCAYMNDQGKCLRGEGTCITQNSQQCMLKKIFEGGKLQFMVQGCENMCPSMNLFSHGTRMQIICCRNQSFCNK 194
Cdd:cd23628   2 ALTCFQCDRMNSDGICETGEGTCEAQNSQQCMLKKIFEGGKLQYGVQGCSNLCPNMTLFSGNTRVEITCCRNQSFCNK 79
TFP_LU_ECD_PATE3 cd23579
extracellular domain (ECD) found in prostate and testis expressed protein 3 (PATE3) and ...
 116-194 4.16e-10

extracellular domain (ECD) found in prostate and testis expressed protein 3 (PATE3) and similar proteins; PATE3 (also called acrosomal vesicle protein HEL-127, or PATE-like protein DJ (PATE-DJ)) is a member of the prostate and testis expression (PATE)-like family of proteins that likely play important roles in reproductive and neuronal physiology. They are expressed mainly in the male genital tract and involved in sperm-oolemma fusion and penetration, but not sperm-zona binding. PATE3 contains an extracellular domain (ECD), which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467109  Cd Length: 80  Bit Score: 53.97  E-value: 4.16e-10
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 9955931  116 TILNCYTCAYMNDQGKCLRGEGTCITQNSQQCMLKKIFEGGKLQFMVQGCENMCPSMNLFSHGTRMQIICCrNQSFCNK 194
Cdd:cd23579   3 TALKCITCHLRTVSDRCRRGFGTCTAQKDESCMRLRIYQGDTLQLSYMVCQKFCRDLTYHFNNRTYVHTCC-NKDYCNF 80
TFP_LU_ECD_Ly6G5b cd23544
extracellular domain (ECD) found in lymphocyte antigen 6 complex locus protein G5b (Ly6G5b) ...
 117-194 6.90e-09

extracellular domain (ECD) found in lymphocyte antigen 6 complex locus protein G5b (Ly6G5b) and similar proteins; Ly6G5b is a glycosylated, potentially secreted protein which could act as ligand for other cell-surface receptors and could thus potentially have a role in cell signaling. It contains an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467074  Cd Length: 82  Bit Score: 50.86  E-value: 6.90e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9955931  117 ILNCYTCAYMNDQGKCLRGEGTCITQNSQQCMLKKIFEGGKLQFMVQGC---ENMCPSMNLFS--HGTRMQIICCrNQSF 191
Cdd:cd23544   1 ARRCHLCLLEDPSIGCISGSEKCTPSSGEPCMTITIYYEGKVRFLVRGCgqhSSYRCGERKKTyvSGYWYNARCC-QYDY 79


                ...
gi 9955931  192 CNK 194
Cdd:cd23544  80 CNS 82
TFP_LU_ECD_PATE2 cd23578
extracellular domain (ECD) found in prostate and testis expressed protein 2 (PATE2) and ...
 118-193 1.27e-08

extracellular domain (ECD) found in prostate and testis expressed protein 2 (PATE2) and similar proteins; PATE2 (also called PATE-like protein M (PATE-M)) is a member of the prostate and testis expression (PATE)-like family of proteins that likely play important roles in reproductive and neuronal physiology. They are expressed mainly in the male genital tract and involved in sperm-oolemma fusion and penetration, but not sperm-zona binding. PATE2 contains an extracellular domain (ECD), which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467108  Cd Length: 82  Bit Score: 50.02  E-value: 1.27e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9955931  118 LNCYTCAYMNDqGKCLRGEGTCITQNSQQCMLKKIF----EGGKL-QFMVQGCENMCPSMNLFSHGTRMQIICCRNQSFC 192
Cdd:cd23578   3 TVCMVCKHFKG-GRCLEGMGSCTKKYGSGCRTRNFYiysnTGGWLyTYSKLDCVTRCKESVMYFHDLKVETFCCKDQDYC 81


                .
gi 9955931  193 N 193
Cdd:cd23578  82 N 82
TFP_LU_ECD_mPATE6_like cd23581
extracellular domain (ECD) found in Mus musculus prostate and testis expressed protein 6 ...
 118-193 4.40e-07

extracellular domain (ECD) found in Mus musculus prostate and testis expressed protein 6 (PATE6) and similar proteins; The family includes Mus musculus PATE6 and PATE7. PATE6 (also called called prostate and testis expressed 6, or PATE-like protein C) acts as nicotinic acetylcholine receptor (nAChR) regulator. The biological function of PATE7 (also called called prostate and testis expressed 7) remains unclear. Members in this family contain an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467111  Cd Length: 82  Bit Score: 45.92  E-value: 4.40e-07
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 9955931  118 LNCYTCAYMNDqGKCLRGEGTCITQNSQQCMLKKIF---EGGKLQFMVQGCENMCPSMNLFSHGTRMQIICCRNQSFCN 193
Cdd:cd23581   4 LQCNQCLSYKD-GECVHGKQTCTAKPGESCMIRRIFsasESVTINSAERGCTKNCTSTEDISGDYTVITTCCSDFDFCN 81
TFP_LU_ECD_PATE1 cd23577
extracellular domain (ECD) found in prostate and testis expressed protein 1 (PATE1) and ...
 117-193 1.79e-06

extracellular domain (ECD) found in prostate and testis expressed protein 1 (PATE1) and similar proteins; PATE1 is a novel sperm-associated protein generally expressed in male genital tract and related to sperm development, maturation and fertilization. It contains an extracellular domain (ECD), which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467107  Cd Length: 82  Bit Score: 44.37  E-value: 1.79e-06
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 9955931  117 ILNCYTCAYMNDQGKCLRGEGTCITQNSQQCMLKKIFEG-GKLQFMVQGCENMCPSMNLFSHGT-RMQIICCRNQSFCN 193
Cdd:cd23577   1 IVQCRMCHLQFPGEKCSRGRGICTATTEEACVVGRIFKKdGTPWLTFMGCLKNCANVKKIKWSVyLVNFRCCRGYDLCN 79
TFP_LU_ECD_C9orf57 cd23610
extracellular domain (ECD) found in Homo sapiens uncharacterized protein C9orf57 and similar ...
 120-194 3.02e-06

extracellular domain (ECD) found in Homo sapiens uncharacterized protein C9orf57 and similar proteins; C9orf57 contains an extracellular domain (ECD) that belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467130  Cd Length: 83  Bit Score: 43.65  E-value: 3.02e-06
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 9955931  120 CYTCAYMNDQGKCLRGEGTCITQNSQQCMLKKIFEGGKLQFMVQGC---ENMCPSMNLFSHGTRMQIICCrNQSFCNK 194
Cdd:cd23610   7 CRMCNLSKPFHGCTLGGGTCLAKPGQYCKTERHIKGGIEWFSIKGCtknSEECGSTKEVGYSGRVTTTCC-NSHMCNF 83
TFP_LU_ECD_PATE4 cd23580
extracellular domain (ECD) found in prostate and testis expressed protein 4 (PATE4) and ...
 118-193 2.99e-05

extracellular domain (ECD) found in prostate and testis expressed protein 4 (PATE4) and similar proteins; PATE4, also called prostate and testis expressed 4, or PATE-like protein B) is a member of the prostate and testis expression (PATE)-like family of proteins that likely play important roles in reproductive and neuronal physiology. They are expressed mainly in the male genital tract and involved in sperm-oolemma fusion and penetration, but not sperm-zona binding. PATE4 may modulate the function of nicotinic acetylcholine receptors and enhance sperm motility. PATE4 contains an extracellular domain (ECD), which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467110  Cd Length: 79  Bit Score: 40.85  E-value: 2.99e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 9955931  118 LNCYTCAYMNDQgKCLRGEGTCITQNSQQCMLKKIFEGGKLQFMVQGCENMCPSmNLFSHGTRMQIICCRNQSFCN 193
Cdd:cd23580   4 LICNVCIYSKNS-RCMSGQGRCTAKPGGSCSTISYYRGSKHLYSKHMCKYHCKE-EQYYKGDLLRYTMCCEKNLCN 77
CobT2 COG4547
Cobalamin biosynthesis cobaltochelatase CobT subunit [Coenzyme transport and metabolism]; ...
 24-115 7.61e-03

Cobalamin biosynthesis cobaltochelatase CobT subunit [Coenzyme transport and metabolism]; Cobalamin biosynthesis cobaltochelatase CobT subunit is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 443611 [Multi-domain]  Cd Length: 608  Bit Score: 36.70  E-value: 7.61e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9955931   24 NELSGSIDHQTSVQQL-------------PGEQPSGEQPSGEHLSGEQPLSELESGEQPSDEQPSGEHGSGEQPSGEQAS 90
Cdd:COG4547 182 DRLAELLDDQAAFARAvrdllrdldlaeeLGEDEDEEDEDDEDDSGEQEEDEEDGEDEDEESDEGAEAEDAEASGDDAEE 261

                        90       100
                ....*....|....*....|....*
gi 9955931   91 GEQPSGEHASGEQASGAPISSTSTG 115
Cdd:COG4547 262 GESEAAEAESDEMAEEAEGEDSEEP 286
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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