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Conserved domains on  [gi|31982699|ref|NP_064386|]
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meiotic recombination protein REC8 homolog isoform 1 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Rad21_Rec8_N pfam04825
N terminus of Rad21 / Rec8 like protein; This family represents a conserved N-terminal region ...
 1-112 5.84e-29

N terminus of Rad21 / Rec8 like protein; This family represents a conserved N-terminal region found in eukaryotic cohesins of the Rad21, Rec8 and Scc1 families. Members of this family mediate sister chromatid cohesion during mitosis and meiosis, as part of the cohesin complex. Cohesion is necessary for homologous recombination (including double-strand break repair) and correct chromatid segregation. These proteins may also be involved in chromosome condensation. Dissociation at the metaphase to anaphase transition causes loss of cohesion and chromatid segregation.


:

Pssm-ID: 461446  Cd Length: 104  Bit Score: 110.72  E-value: 5.84e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982699     1 MFYYPNVLqRHTGCFATIWLAATRGSRLVKREYLNVNVVKTCEEILNyvlvrvqppvaglPRPRFSLYLSAQLQIGVIRV 80
Cdd:pfam04825   1 MFYSHEIL-SKKGPLATVWLAATLGKKLSKKQILEVDIPKACETIIN-------------PEAPLALRLSGQLLLGVVRI 66

                          90       100       110
                  ....*....|....*....|....*....|..
gi 31982699    81 YFQQCQYLVEDIQHILEHLHRAQLRIRIDMEE 112
Cdd:pfam04825  67 YSRKAKYLLDDCNEALVKIKKAFRPGQVDLPA 98
Rad21_Rec8 pfam04824
Conserved region of Rad21 / Rec8 like protein; This family represents a conserved region found ...
 536-590 6.22e-19

Conserved region of Rad21 / Rec8 like protein; This family represents a conserved region found in eukaryotic cohesins of the Rad21, Rec8 and Scc1 families. Members of this family mediate sister chromatid cohesion during mitosis and meiosis, as part of the cohesin complex. Cohesion is necessary for homologous recombination (including double-strand break repair) and correct chromatid segregation. These proteins may also be involved in chromosome condensation. Dissociation at the metaphase to anaphase transition causes loss of cohesion and chromatid segregation.


:

Pssm-ID: 335912  Cd Length: 55  Bit Score: 80.45  E-value: 6.22e-19
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 31982699   536 ANKELDFSSLVPPLSPRKLASRVFYLLLVLSTQKILLVEQQKPYGPLLIRPGPKF 590
Cdd:pfam04824   1 TEGEKDSLSLLPAGKTRKEAARLFYELLVLATKGAIKVKQEEPYGDILITPGPKF 55
Rad21_Rec8_M_Rec8 cd21794
Middle HEAT-repeat binding domain found in Homo sapiens meiotic recombination protein REC8 ...
 350-414 3.67e-12

Middle HEAT-repeat binding domain found in Homo sapiens meiotic recombination protein REC8 homolog and similar proteins; Rec8, also called cohesin Rec8p, is a meiotic recombination and sister chromatid cohesion phosphoprotein of the Rad21p family conserved from fission yeast to humans. It is required during meiosis for separation of sister chromatids and homologous chromosomes. Proteolytic cleavage of Rec8 on chromosome arms by separin during anaphase I allows for homologous chromosome separation in meiosis I, and cleavage of Rec8 on centromeres during anaphase II allows for sister chromatid separation in meiosis II. This model corresponds to a small region in the middle of Rec8 that shows high sequence similarity with the HEAT-repeat binding domain found in both the middle of Saccharomyces cerevisiae sister chromatid cohesion protein 1 (ScScc1p) and Homo sapiens nuclear matrix protein 1 (NXP-1), which consists of short helices and two long extended segments.


:

Pssm-ID: 439296 [Multi-domain]  Cd Length: 75  Bit Score: 61.94  E-value: 3.67e-12
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 31982699 350 DKETQISREKFEEQLQTGAH-CWEYPVAQPPKRMLtSPAELFRTPTLSGWLPPELLGLWTHCAQVP 414
Cdd:cd21794  11 DENTQLSKEELRKNMQNVTStRTMVPLVLPLLRPP-SAAELFSRPGRKLLWSPKLLRLWRRNAKLP 75
 
Name Accession Description Interval E-value
Rad21_Rec8_N pfam04825
N terminus of Rad21 / Rec8 like protein; This family represents a conserved N-terminal region ...
 1-112 5.84e-29

N terminus of Rad21 / Rec8 like protein; This family represents a conserved N-terminal region found in eukaryotic cohesins of the Rad21, Rec8 and Scc1 families. Members of this family mediate sister chromatid cohesion during mitosis and meiosis, as part of the cohesin complex. Cohesion is necessary for homologous recombination (including double-strand break repair) and correct chromatid segregation. These proteins may also be involved in chromosome condensation. Dissociation at the metaphase to anaphase transition causes loss of cohesion and chromatid segregation.


Pssm-ID: 461446  Cd Length: 104  Bit Score: 110.72  E-value: 5.84e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982699     1 MFYYPNVLqRHTGCFATIWLAATRGSRLVKREYLNVNVVKTCEEILNyvlvrvqppvaglPRPRFSLYLSAQLQIGVIRV 80
Cdd:pfam04825   1 MFYSHEIL-SKKGPLATVWLAATLGKKLSKKQILEVDIPKACETIIN-------------PEAPLALRLSGQLLLGVVRI 66

                          90       100       110
                  ....*....|....*....|....*....|..
gi 31982699    81 YFQQCQYLVEDIQHILEHLHRAQLRIRIDMEE 112
Cdd:pfam04825  67 YSRKAKYLLDDCNEALVKIKKAFRPGQVDLPA 98
Rad21_Rec8 pfam04824
Conserved region of Rad21 / Rec8 like protein; This family represents a conserved region found ...
 536-590 6.22e-19

Conserved region of Rad21 / Rec8 like protein; This family represents a conserved region found in eukaryotic cohesins of the Rad21, Rec8 and Scc1 families. Members of this family mediate sister chromatid cohesion during mitosis and meiosis, as part of the cohesin complex. Cohesion is necessary for homologous recombination (including double-strand break repair) and correct chromatid segregation. These proteins may also be involved in chromosome condensation. Dissociation at the metaphase to anaphase transition causes loss of cohesion and chromatid segregation.


Pssm-ID: 335912  Cd Length: 55  Bit Score: 80.45  E-value: 6.22e-19
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 31982699   536 ANKELDFSSLVPPLSPRKLASRVFYLLLVLSTQKILLVEQQKPYGPLLIRPGPKF 590
Cdd:pfam04824   1 TEGEKDSLSLLPAGKTRKEAARLFYELLVLATKGAIKVKQEEPYGDILITPGPKF 55
Rad21_Rec8_M_Rec8 cd21794
Middle HEAT-repeat binding domain found in Homo sapiens meiotic recombination protein REC8 ...
 350-414 3.67e-12

Middle HEAT-repeat binding domain found in Homo sapiens meiotic recombination protein REC8 homolog and similar proteins; Rec8, also called cohesin Rec8p, is a meiotic recombination and sister chromatid cohesion phosphoprotein of the Rad21p family conserved from fission yeast to humans. It is required during meiosis for separation of sister chromatids and homologous chromosomes. Proteolytic cleavage of Rec8 on chromosome arms by separin during anaphase I allows for homologous chromosome separation in meiosis I, and cleavage of Rec8 on centromeres during anaphase II allows for sister chromatid separation in meiosis II. This model corresponds to a small region in the middle of Rec8 that shows high sequence similarity with the HEAT-repeat binding domain found in both the middle of Saccharomyces cerevisiae sister chromatid cohesion protein 1 (ScScc1p) and Homo sapiens nuclear matrix protein 1 (NXP-1), which consists of short helices and two long extended segments.


Pssm-ID: 439296 [Multi-domain]  Cd Length: 75  Bit Score: 61.94  E-value: 3.67e-12
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 31982699 350 DKETQISREKFEEQLQTGAH-CWEYPVAQPPKRMLtSPAELFRTPTLSGWLPPELLGLWTHCAQVP 414
Cdd:cd21794  11 DENTQLSKEELRKNMQNVTStRTMVPLVLPLLRPP-SAAELFSRPGRKLLWSPKLLRLWRRNAKLP 75
 
Name Accession Description Interval E-value
Rad21_Rec8_N pfam04825
N terminus of Rad21 / Rec8 like protein; This family represents a conserved N-terminal region ...
 1-112 5.84e-29

N terminus of Rad21 / Rec8 like protein; This family represents a conserved N-terminal region found in eukaryotic cohesins of the Rad21, Rec8 and Scc1 families. Members of this family mediate sister chromatid cohesion during mitosis and meiosis, as part of the cohesin complex. Cohesion is necessary for homologous recombination (including double-strand break repair) and correct chromatid segregation. These proteins may also be involved in chromosome condensation. Dissociation at the metaphase to anaphase transition causes loss of cohesion and chromatid segregation.


Pssm-ID: 461446  Cd Length: 104  Bit Score: 110.72  E-value: 5.84e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982699     1 MFYYPNVLqRHTGCFATIWLAATRGSRLVKREYLNVNVVKTCEEILNyvlvrvqppvaglPRPRFSLYLSAQLQIGVIRV 80
Cdd:pfam04825   1 MFYSHEIL-SKKGPLATVWLAATLGKKLSKKQILEVDIPKACETIIN-------------PEAPLALRLSGQLLLGVVRI 66

                          90       100       110
                  ....*....|....*....|....*....|..
gi 31982699    81 YFQQCQYLVEDIQHILEHLHRAQLRIRIDMEE 112
Cdd:pfam04825  67 YSRKAKYLLDDCNEALVKIKKAFRPGQVDLPA 98
Rad21_Rec8 pfam04824
Conserved region of Rad21 / Rec8 like protein; This family represents a conserved region found ...
 536-590 6.22e-19

Conserved region of Rad21 / Rec8 like protein; This family represents a conserved region found in eukaryotic cohesins of the Rad21, Rec8 and Scc1 families. Members of this family mediate sister chromatid cohesion during mitosis and meiosis, as part of the cohesin complex. Cohesion is necessary for homologous recombination (including double-strand break repair) and correct chromatid segregation. These proteins may also be involved in chromosome condensation. Dissociation at the metaphase to anaphase transition causes loss of cohesion and chromatid segregation.


Pssm-ID: 335912  Cd Length: 55  Bit Score: 80.45  E-value: 6.22e-19
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 31982699   536 ANKELDFSSLVPPLSPRKLASRVFYLLLVLSTQKILLVEQQKPYGPLLIRPGPKF 590
Cdd:pfam04824   1 TEGEKDSLSLLPAGKTRKEAARLFYELLVLATKGAIKVKQEEPYGDILITPGPKF 55
Rad21_Rec8_M_Rec8 cd21794
Middle HEAT-repeat binding domain found in Homo sapiens meiotic recombination protein REC8 ...
 350-414 3.67e-12

Middle HEAT-repeat binding domain found in Homo sapiens meiotic recombination protein REC8 homolog and similar proteins; Rec8, also called cohesin Rec8p, is a meiotic recombination and sister chromatid cohesion phosphoprotein of the Rad21p family conserved from fission yeast to humans. It is required during meiosis for separation of sister chromatids and homologous chromosomes. Proteolytic cleavage of Rec8 on chromosome arms by separin during anaphase I allows for homologous chromosome separation in meiosis I, and cleavage of Rec8 on centromeres during anaphase II allows for sister chromatid separation in meiosis II. This model corresponds to a small region in the middle of Rec8 that shows high sequence similarity with the HEAT-repeat binding domain found in both the middle of Saccharomyces cerevisiae sister chromatid cohesion protein 1 (ScScc1p) and Homo sapiens nuclear matrix protein 1 (NXP-1), which consists of short helices and two long extended segments.


Pssm-ID: 439296 [Multi-domain]  Cd Length: 75  Bit Score: 61.94  E-value: 3.67e-12
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 31982699 350 DKETQISREKFEEQLQTGAH-CWEYPVAQPPKRMLtSPAELFRTPTLSGWLPPELLGLWTHCAQVP 414
Cdd:cd21794  11 DENTQLSKEELRKNMQNVTStRTMVPLVLPLLRPP-SAAELFSRPGRKLLWSPKLLRLWRRNAKLP 75
Rad21_Rec8_M cd21747
Middle HEAT-repeat binding domain of Rad21/Rec8-like proteins; This family includes eukaryotic ...
 349-414 6.63e-05

Middle HEAT-repeat binding domain of Rad21/Rec8-like proteins; This family includes eukaryotic cohesins of the Rad21, Rec8, and Scc1 subfamilies. They mediate sister chromatid cohesion during mitosis and meiosis, as part of the cohesin complex. Cohesion is necessary for homologous recombination (including double-strand break repair) and correct chromatid segregation. These proteins may also be involved in chromosome condensation. Dissociation at the metaphase to anaphase transition causes loss of cohesion and chromatid segregation. This model corresponds to a conserved middle/central region of family members, consisting of short helices and two extended segments, which functions in binding to HEAT-repeat containing cohesin subunits. For example, human Scc1 homolog (NXP-1) binds to either SA1 or SA2, two homologous HEAT-containing proteins; the SA-Scc1 heterodimer mediates the binding between cohesin and its regulators, including Scc2-Scc4, Pds5, Wapl, and Sgo1.


Pssm-ID: 439289 [Multi-domain]  Cd Length: 79  Bit Score: 41.68  E-value: 6.63e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 31982699 349 WDKETQISREKFEEQLQ-TGAHCWEY-PVAQPPKRMLTS---PAELFRTPTLSGWlPPELLGLWTHCAQVP 414
Cdd:cd21747  10 IDEVTELSTEQMRSQLQdTSDIVRSRdLNPPTPVRPLRKasgTDSLFSLNPLSGW-DNALLELFPSPLRPQ 79
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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