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Conserved domains on  [gi|23199987|ref|NP_061942|]
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WD repeat-containing protein 5B [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
36-326 6.31e-109

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 323.02  E-value: 6.31e-109
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23199987  36 TLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSG 115
Cdd:COG2319 115 TLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATG 194

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23199987 116 KCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWD 195
Cdd:COG2319 195 KLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWD 274

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23199987 196 AASGQCLKTLvDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIfaNFSvTGGKWIVSGSE 275
Cdd:COG2319 275 LATGELLRTL-TGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSV--AFS-PDGKTLASGSD 350

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 23199987 276 DNLVYIWNLQTKEIVQKLQGHTDVVISAACHPTENLIASAAleNDKTIKLW 326
Cdd:COG2319 351 DGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGS--ADGTVRLW 399
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
36-326 6.31e-109

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 323.02  E-value: 6.31e-109
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23199987  36 TLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSG 115
Cdd:COG2319 115 TLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATG 194

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23199987 116 KCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWD 195
Cdd:COG2319 195 KLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWD 274

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23199987 196 AASGQCLKTLvDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIfaNFSvTGGKWIVSGSE 275
Cdd:COG2319 275 LATGELLRTL-TGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSV--AFS-PDGKTLASGSD 350

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 23199987 276 DNLVYIWNLQTKEIVQKLQGHTDVVISAACHPTENLIASAAleNDKTIKLW 326
Cdd:COG2319 351 DGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGS--ADGTVRLW 399
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 33-326 1.02e-102

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 303.10  E-value: 1.02e-102
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23199987  33 LKCTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSSRLVSASDDKTLKLWDV 112
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23199987 113 RSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCR 192
Cdd:cd00200  81 ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIK 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23199987 193 IWDAASGQCLKTLVDDDNpPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNekYCIFANFSvTGGKWIVS 272
Cdd:cd00200 161 LWDLRTGKCVATLTGHTG-EVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHEN--GVNSVAFS-PDGYLLAS 236

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 23199987 273 GSEDNLVYIWNLQTKEIVQKLQGHTDVVISAACHPTENLIASAALenDKTIKLW 326
Cdd:cd00200 237 GSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSA--DGTIRIW 288
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 37-283 2.61e-19

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 88.99  E-value: 2.61e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23199987   37 LVGHTEAVSSVKFSPNGEWLASSSADRLI-------IIWGAYDGKYEKTLYGHNLEISDVAWSSD-SSRLVSASDDKTLK 108
Cdd:PLN00181 479 LLNSSNLVCAIGFDRDGEFFATAGVNKKIkifecesIIKDGRDIHYPVVELASRSKLSGICWNSYiKSQVASSNFEGVVQ 558

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23199987  109 LWDVRSGKCLKTLKGHSNYVFCCNFNPPS-NLIISGSFDETVKIWEVKTGKCLKTLSAHSDpVSAVHFNC-SGSLIVSGS 186
Cdd:PLN00181 559 VWDVARSQLVTEMKEHEKRVWSIDYSSADpTLLASGSDDGSVKLWSINQGVSIGTIKTKAN-ICCVQFPSeSGRSLAFGS 637

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23199987  187 YDGLCRIWDAASGQCLKTLVDDDNPPVSFVKFSPNGKYILTATlDNTLKLWDYSRGRC------LKTYTGHKNEKYciFA 260
Cdd:PLN00181 638 ADHKVYYYDLRNPKLPLCTMIGHSKTVSYVRFVDSSTLVSSST-DNTLKLWDLSMSISginetpLHSFMGHTNVKN--FV 714

                        250       260
                 ....*....|....*....|...
gi 23199987  261 NFSVTGGkWIVSGSEDNLVYIWN 283
Cdd:PLN00181 715 GLSVSDG-YIATGSETNEVFVYH 736
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 156-195 7.69e-10

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 53.47  E-value: 7.69e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 23199987    156 TGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWD 195
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
157-195 3.82e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 51.58  E-value: 3.82e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 23199987   157 GKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWD 195
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
36-326 6.31e-109

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 323.02  E-value: 6.31e-109
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23199987  36 TLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSG 115
Cdd:COG2319 115 TLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATG 194

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23199987 116 KCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWD 195
Cdd:COG2319 195 KLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWD 274

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23199987 196 AASGQCLKTLvDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIfaNFSvTGGKWIVSGSE 275
Cdd:COG2319 275 LATGELLRTL-TGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSV--AFS-PDGKTLASGSD 350

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 23199987 276 DNLVYIWNLQTKEIVQKLQGHTDVVISAACHPTENLIASAAleNDKTIKLW 326
Cdd:COG2319 351 DGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGS--ADGTVRLW 399
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 33-326 1.02e-102

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 303.10  E-value: 1.02e-102
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23199987  33 LKCTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSSRLVSASDDKTLKLWDV 112
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23199987 113 RSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCR 192
Cdd:cd00200  81 ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIK 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23199987 193 IWDAASGQCLKTLVDDDNpPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNekYCIFANFSvTGGKWIVS 272
Cdd:cd00200 161 LWDLRTGKCVATLTGHTG-EVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHEN--GVNSVAFS-PDGYLLAS 236

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 23199987 273 GSEDNLVYIWNLQTKEIVQKLQGHTDVVISAACHPTENLIASAALenDKTIKLW 326
Cdd:cd00200 237 GSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSA--DGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
36-326 1.68e-98

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 296.44  E-value: 1.68e-98
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23199987  36 TLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSG 115
Cdd:COG2319  73 TLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATG 152

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23199987 116 KCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWD 195
Cdd:COG2319 153 KLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWD 232

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23199987 196 AASGQCLKTLvDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIfaNFSvTGGKWIVSGSE 275
Cdd:COG2319 233 LATGKLLRTL-TGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSV--AFS-PDGKLLASGSD 308

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 23199987 276 DNLVYIWNLQTKEIVQKLQGHTDVVISAACHPTENLIASAAleNDKTIKLW 326
Cdd:COG2319 309 DGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGS--DDGTVRLW 357
WD40 COG2319
WD40 repeat [General function prediction only];
36-286 6.53e-89

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 271.78  E-value: 6.53e-89
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23199987  36 TLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSG 115
Cdd:COG2319 157 TLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATG 236

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23199987 116 KCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWD 195
Cdd:COG2319 237 KLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWD 316

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23199987 196 AASGQCLKTLVDDDNPPVSfVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFanFSVTgGKWIVSGSE 275
Cdd:COG2319 317 LATGKLLRTLTGHTGAVRS-VAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVA--FSPD-GRTLASGSA 392

                       250
                ....*....|.
gi 23199987 276 DNLVYIWNLQT 286
Cdd:COG2319 393 DGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
36-326 1.93e-86

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 265.62  E-value: 1.93e-86
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23199987  36 TLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSG 115
Cdd:COG2319  31 LLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATG 110

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23199987 116 KCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWD 195
Cdd:COG2319 111 LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWD 190

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23199987 196 AASGQCLKTLVDDDNpPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIfaNFSvTGGKWIVSGSE 275
Cdd:COG2319 191 LATGKLLRTLTGHTG-AVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSV--AFS-PDGRLLASGSA 266

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 23199987 276 DNLVYIWNLQTKEIVQKLQGHTDVVISAACHPTENLIASAAleNDKTIKLW 326
Cdd:COG2319 267 DGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGS--DDGTVRLW 315
WD40 COG2319
WD40 repeat [General function prediction only];
49-326 5.13e-69

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 220.94  E-value: 5.13e-69
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23199987  49 FSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYV 128
Cdd:COG2319   2 LSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAV 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23199987 129 FCCNFNPPSNLIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDD 208
Cdd:COG2319  82 LSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGH 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23199987 209 DNPPVSfVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIfaNFSvTGGKWIVSGSEDNLVYIWNLQTKE 288
Cdd:COG2319 162 SGAVTS-VAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSV--AFS-PDGKLLASGSADGTVRLWDLATGK 237

                       250       260       270
                ....*....|....*....|....*....|....*...
gi 23199987 289 IVQKLQGHTDVVISAACHPTENLIASAAleNDKTIKLW 326
Cdd:COG2319 238 LLRTLTGHSGSVRSVAFSPDGRLLASGS--ADGTVRLW 273
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 36-238 1.10e-65

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 208.73  E-value: 1.10e-65
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23199987  36 TLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSG 115
Cdd:cd00200  88 TLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTG 167

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23199987 116 KCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWD 195
Cdd:cd00200 168 KCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWD 247

                       170       180       190       200
                ....*....|....*....|....*....|....*....|...
gi 23199987 196 AASGQCLKTLVDDDNPpVSFVKFSPNGKYILTATLDNTLKLWD 238
Cdd:cd00200 248 LRTGECVQTLSGHTNS-VTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 12-195 3.02e-53

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 176.37  E-value: 3.02e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23199987  12 QLALSSSANQSKEVPENPNYALKCTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAW 91
Cdd:cd00200 106 RILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAF 185

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23199987  92 SSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGKCLKTLSAHSDPVS 171
Cdd:cd00200 186 SPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVT 265

                       170       180
                ....*....|....*....|....
gi 23199987 172 AVHFNCSGSLIVSGSYDGLCRIWD 195
Cdd:cd00200 266 SLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
90-326 3.41e-50

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 172.02  E-value: 3.41e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23199987  90 AWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGKCLKTLSAHSDP 169
Cdd:COG2319   1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23199987 170 VSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSfVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYT 249
Cdd:COG2319  81 VLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRS-VAFSPDGKTLASGSADGTVRLWDLATGKLLRTLT 159

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 23199987 250 GHKNEKYCIfaNFSvTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISAACHPTENLIASAAleNDKTIKLW 326
Cdd:COG2319 160 GHSGAVTSV--AFS-PDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGS--ADGTVRLW 231
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 37-283 2.61e-19

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 88.99  E-value: 2.61e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23199987   37 LVGHTEAVSSVKFSPNGEWLASSSADRLI-------IIWGAYDGKYEKTLYGHNLEISDVAWSSD-SSRLVSASDDKTLK 108
Cdd:PLN00181 479 LLNSSNLVCAIGFDRDGEFFATAGVNKKIkifecesIIKDGRDIHYPVVELASRSKLSGICWNSYiKSQVASSNFEGVVQ 558

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23199987  109 LWDVRSGKCLKTLKGHSNYVFCCNFNPPS-NLIISGSFDETVKIWEVKTGKCLKTLSAHSDpVSAVHFNC-SGSLIVSGS 186
Cdd:PLN00181 559 VWDVARSQLVTEMKEHEKRVWSIDYSSADpTLLASGSDDGSVKLWSINQGVSIGTIKTKAN-ICCVQFPSeSGRSLAFGS 637

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23199987  187 YDGLCRIWDAASGQCLKTLVDDDNPPVSFVKFSPNGKYILTATlDNTLKLWDYSRGRC------LKTYTGHKNEKYciFA 260
Cdd:PLN00181 638 ADHKVYYYDLRNPKLPLCTMIGHSKTVSYVRFVDSSTLVSSST-DNTLKLWDLSMSISginetpLHSFMGHTNVKN--FV 714

                        250       260
                 ....*....|....*....|...
gi 23199987  261 NFSVTGGkWIVSGSEDNLVYIWN 283
Cdd:PLN00181 715 GLSVSDG-YIATGSETNEVFVYH 736
PTZ00421 PTZ00421
coronin; Provisional
 79-199 2.09e-13

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 70.69  E-value: 2.09e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23199987   79 LYGHNLEISDVAWSS-DSSRLVSASDDKTLKLWDV-------RSGKCLKTLKGHSNYVFCCNFNPPS-NLIISGSFDETV 149
Cdd:PTZ00421  71 LLGQEGPIIDVAFNPfDPQKLFTASEDGTIMGWGIpeegltqNISDPIVHLQGHTKKVGIVSFHPSAmNVLASAGADMVV 150

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 23199987  150 KIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASG 199
Cdd:PTZ00421 151 NVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDG 200
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 156-195 7.69e-10

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 53.47  E-value: 7.69e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 23199987    156 TGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWD 195
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 114-153 2.53e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 51.93  E-value: 2.53e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 23199987    114 SGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWE 153
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
157-195 3.82e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 51.58  E-value: 3.82e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 23199987   157 GKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWD 195
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 140-320 6.81e-09

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 57.02  E-value: 6.81e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23199987  140 IISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSG-SLIVSGSYDGLCRIWDAASGQCLKTLVDDDNppVSFVKF 218
Cdd:PLN00181 548 VASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADpTLLASGSDDGSVKLWSINQGVSIGTIKTKAN--ICCVQF 625

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23199987  219 -SPNGKYILTATLDNTLKLWDYSRGRC-LKTYTGH-KNEKYCIFANFSVtggkwIVSGSEDNLVYIWNLQ------TKEI 289
Cdd:PLN00181 626 pSESGRSLAFGSADHKVYYYDLRNPKLpLCTMIGHsKTVSYVRFVDSST-----LVSSSTDNTLKLWDLSmsisgiNETP 700

                        170       180       190
                 ....*....|....*....|....*....|.
gi 23199987  290 VQKLQGHTDVVISAACHPTENLIASAALEND 320
Cdd:PLN00181 701 LHSFMGHTNVKNFVGLSVSDGYIATGSETNE 731
PTZ00421 PTZ00421
coronin; Provisional
 37-155 8.20e-09

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 56.44  E-value: 8.20e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23199987   37 LVGHTEAVSSVKFSPNGE-WLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSG 115
Cdd:PTZ00421 121 LQGHTKKVGIVSFHPSAMnVLASAGADMVVNVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDG 200

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 23199987  116 KCLKTLKGH-SNYVFCCNFNPPSNLIISGSFDET----VKIWEVK 155
Cdd:PTZ00421 201 TIVSSVEAHaSAKSQRCLWAKRKDLIITLGCSKSqqrqIMLWDTR 245
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 72-111 1.03e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 50.39  E-value: 1.03e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 23199987     72 DGKYEKTLYGHNLEISDVAWSSDSSRLVSASDDKTLKLWD 111
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
115-153 1.51e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 50.04  E-value: 1.51e-08
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 23199987   115 GKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWE 153
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
73-111 5.93e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 48.11  E-value: 5.93e-08
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 23199987    73 GKYEKTLYGHNLEISDVAWSSDSSRLVSASDDKTLKLWD 111
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00421 PTZ00421
coronin; Provisional
 25-166 7.03e-08

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 53.74  E-value: 7.03e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23199987   25 VPENPNyalkcTLVGHTEAVSSVKFSP-NGEWLASSSADRLIIIWG-AYDGKYEKT------LYGHNLEISDVAW-SSDS 95
Cdd:PTZ00421  64 LASNPP-----ILLGQEGPIIDVAFNPfDPQKLFTASEDGTIMGWGiPEEGLTQNIsdpivhLQGHTKKVGIVSFhPSAM 138

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 23199987   96 SRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGKCLKTLSAH 166
Cdd:PTZ00421 139 NVLASAGADMVVNVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAH 209
WD40 pfam00400
WD domain, G-beta repeat;
36-68 2.77e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.18  E-value: 2.77e-07
                          10        20        30
                  ....*....|....*....|....*....|...
gi 23199987    36 TLVGHTEAVSSVKFSPNGEWLASSSADRLIIIW 68
Cdd:pfam00400   6 TLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 33-68 3.45e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.15  E-value: 3.45e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 23199987     33 LKCTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIW 68
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 15-189 3.65e-06

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 48.54  E-value: 3.65e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23199987   15 LSSSANQSKEVPENPNYALKCTLVGHTEAVSSVKF-SPNGEWLASSSADRLIIIwgaYDGKYEK----TLYGHNLEISDV 89
Cdd:PLN00181 591 LASGSDDGSVKLWSINQGVSIGTIKTKANICCVQFpSESGRSLAFGSADHKVYY---YDLRNPKlplcTMIGHSKTVSYV 667

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23199987   90 AWSsDSSRLVSASDDKTLKLWDVR---SG---KCLKTLKGHSNYVFCCNFNPPSNLIISGSfdETVKIWEVKTGKCLKTL 163
Cdd:PLN00181 668 RFV-DSSTLVSSSTDNTLKLWDLSmsiSGineTPLHSFMGHTNVKNFVGLSVSDGYIATGS--ETNEVFVYHKAFPMPVL 744

                        170       180
                 ....*....|....*....|....*....
gi 23199987  164 S---AHSDPVSAVHFNCSGSLIVSGSYDG 189
Cdd:PLN00181 745 SykfKTIDPVSGLEVDDASQFISSVCWRG 773
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 115-313 4.98e-06

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 47.76  E-value: 4.98e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23199987   115 GKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGKCLK-----------------------TLSAHSDPVS 171
Cdd:pfam20426 114 GRMVQSIRQHKDVVSCVAVTSDGSILATGSYDTTVMVWEVLRGRSSEkrsrntqtefprkdhviaetpfhILCGHDDIIT 193

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23199987   172 AVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKFSPNGKYILTAtlDNTLKLWDYS-RGRCLKTYT- 249
Cdd:pfam20426 194 CLYVSVELDIVISGSKDGTCIFHTLREGRYVRSIRHPSGCPLSKLVASRHGRIVLYA--DDDLSLHLYSiNGKHIASSEs 271

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 23199987   250 -GHKNekyCIfaNFSvTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISAACHPTENLIA 313
Cdd:pfam20426 272 nGRLN---CI--ELS-SCGEFLVCAGDQGQIVVRSMNSLEVVRRYNGIGKIITSLTVTPEECFLA 330
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 198-238 2.59e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.76  E-value: 2.59e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 23199987    198 SGQCLKTLVDDDNPpVSFVKFSPNGKYILTATLDNTLKLWD 238
Cdd:smart00320   1 SGELLKTLKGHTGP-VTSVAFSPDGKYLASGSDDGTIKLWD 40
eIF2A pfam08662
Eukaryotic translation initiation factor eIF2A; This is a family of eukaryotic translation ...
 86-256 5.83e-05

Eukaryotic translation initiation factor eIF2A; This is a family of eukaryotic translation initiation factors.


Pssm-ID: 462552 [Multi-domain]  Cd Length: 194  Bit Score: 43.42  E-value: 5.83e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23199987    86 ISDVAWSSDSSR--LVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFccnFNPPSNLIISGSFDET---VKIWEVKTGKCL 160
Cdd:pfam08662  62 IHDVAWSPNGKEfaVIYGYMPAKVSFFDLKGNVIHSFGEQPRNTIF---WSPFGRLVLLAGFGNLagdIEFWDVVNKKKI 138

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23199987   161 KTlsahsdpvsAVHFNCSGslivsgsydglcriwdaasgqclktlvdddnppvsfVKFSPNGKYILTATL------DNTL 234
Cdd:pfam08662 139 AT---------AEASNATL------------------------------------CEWSPDGRYFLTATTaprlrvDNGF 173

                         170       180
                  ....*....|....*....|..
gi 23199987   235 KLWDYSrGRCLktYTGHKNEKY 256
Cdd:pfam08662 174 KIWHYN-GALV--YKYDFDELY 192
PTZ00420 PTZ00420
coronin; Provisional
 121-195 6.04e-05

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 44.56  E-value: 6.04e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23199987  121 LKGHSNYVFCCNFNPP-SNLIISGSFDETVKIW----------EVKTGKCLktLSAHSDPVSAVHFNCSGSLIV-SGSYD 188
Cdd:PTZ00420  70 LKGHTSSILDLQFNPCfSEILASGSEDLTIRVWeiphndesvkEIKDPQCI--LKGHKKKISIIDWNPMNYYIMcSSGFD 147


                 ....*..
gi 23199987  189 GLCRIWD 195
Cdd:PTZ00420 148 SFVNIWD 154
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 286-326 8.27e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.22  E-value: 8.27e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 23199987    286 TKEIVQKLQGHTDVVISAACHPTENLIASAAleNDKTIKLW 326
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGS--DDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
199-238 1.02e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.25  E-value: 1.02e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 23199987   199 GQCLKTLVDDDNPpVSFVKFSPNGKYILTATLDNTLKLWD 238
Cdd:pfam00400   1 GKLLKTLEGHTGS-VTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00420 PTZ00420
coronin; Provisional
 79-158 2.37e-04

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 42.63  E-value: 2.37e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23199987   79 LYGHNLEISDVAWSSDSSR-LVSASDDKTLKLWDVR----SGKCLK----TLKGHSNYVFCCNFNPPSNLII-SGSFDET 148
Cdd:PTZ00420  70 LKGHTSSILDLQFNPCFSEiLASGSEDLTIRVWEIPhndeSVKEIKdpqcILKGHKKKISIIDWNPMNYYIMcSSGFDSF 149

                         90
                 ....*....|
gi 23199987  149 VKIWEVKTGK 158
Cdd:PTZ00420 150 VNIWDIENEK 159
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 114-196 3.04e-04

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 41.98  E-value: 3.04e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23199987   114 SGKCLKTLKGHSNyvfccNFnppsnLIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRI 193
Cdd:pfam20426  81 GAQCFATLQTPSE-----NF-----LISCGNWENSFQVISLNDGRMVQSIRQHKDVVSCVAVTSDGSILATGSYDTTVMV 150


                  ...
gi 23199987   194 WDA 196
Cdd:pfam20426 151 WEV 153
CDC55 COG5170
Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms];
213-277 3.10e-04

Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms];


Pssm-ID: 227498 [Multi-domain]  Cd Length: 460  Bit Score: 42.32  E-value: 3.10e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 23199987 213 VSFVKFSPNGKYILTATLdNTLKLWDYSRGR-CLKTYTGHKN---------EKYCIFANFSVT---GGKWIVSGSEDN 277
Cdd:COG5170 283 ISDFKFSDNGRYILSRDY-LTVKIWDVNMAKnPIKTIPMHCDlmdelndvyENDAIFDKFEISfsgDDKHVLSGSYSN 359
WD40 pfam00400
WD domain, G-beta repeat;
242-283 3.82e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.32  E-value: 3.82e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 23199987   242 GRCLKTYTGHKNEKYCIFANFSvtgGKWIVSGSEDNLVYIWN 283
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPD---GKLLASGSDDGTVKVWD 39
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
139-232 1.18e-03

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 39.68  E-value: 1.18e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23199987 139 LIISGSFDETVKIWEVKTGKCLKTLSAHSDPvSAVHFNCSGS-LIVSGSYDGLCRIWDAASGQCLKTLVDDDNPpvSFVK 217
Cdd:COG3391  82 LYVANSGSGRVSVIDLATGKVVATIPVGGGP-RGLAVDPDGGrLYVADSGNGRVSVIDTATGKVVATIPVGAGP--HGIA 158

                        90
                ....*....|....*
gi 23199987 218 FSPNGKYILTATLDN 232
Cdd:COG3391 159 VDPDGKRLYVANSGS 173
WD40 pfam00400
WD domain, G-beta repeat;
287-326 1.21e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.17  E-value: 1.21e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 23199987   287 KEIVQKLQGHTDVVISAACHPTENLIASAAleNDKTIKLW 326
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGS--DDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 242-283 1.27e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.14  E-value: 1.27e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 23199987    242 GRCLKTYTGHKNEKYCIFANFSvtgGKWIVSGSEDNLVYIWN 283
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPD---GKYLASGSDDGTIKLWD 40
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
 46-226 1.45e-03

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 40.41  E-value: 1.45e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23199987   46 SVKFSPNGEWLASSSaDRliiiwgayDGKYEktLY---------------GHNLEISDVAWSSDSSRLVSASDDKTLKLW 110
Cdd:COG4946  347 LPAWSPDGKSIAYFS-DA--------SGEYE--LYiapadgsgepkqltlGDLGRVFNPVWSPDGKKIAFTDNRGRLWVV 415

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23199987  111 DVRSGKC---LKTLKGHSNYVFccNFNPPSNLI----ISGSFDETVKIWEVKTGKclktlsAHsdPVSavhfncsgsliv 183
Cdd:COG4946  416 DLASGKVrkvDTDGYGDGISDL--AWSPDSKWLayskPGPNQLSQIFLYDVETGK------TV--QLT------------ 473

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 23199987  184 SGSYdglcriwdaasgqclktlvDDDNPpvsfvKFSPNGKYIL 226
Cdd:COG4946  474 DGRY-------------------DDGSP-----AFSPDGKYLY 492
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 81-134 2.88e-03

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 36.49  E-value: 2.88e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 23199987    81 GHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFN 134
Cdd:pfam12894  36 KEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGSDLITCLGWG 89
PTZ00420 PTZ00420
coronin; Provisional
 35-203 3.51e-03

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 39.16  E-value: 3.51e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23199987   35 CTLVGHTEAVSSVKFSP-NGEWLASSSADRLIIIWgayDGKYEKTLYGHNL--EISDVAWSSDSSRLVSASDDKTLKLWD 111
Cdd:PTZ00420 119 CILKGHKKKISIIDWNPmNYYIMCSSGFDSFVNIW---DIENEKRAFQINMpkKLSSLKWNIKGNLLSGTCVGKHMHIID 195

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23199987  112 VRSGKCLKTLKGHS-----NYVFCCNFNPPSNLIISGSFDET----VKIWEVK-TGKCLKTLSAhsDPVSA---VHFNCS 178
Cdd:PTZ00420 196 PRKQEIASSFHIHDggkntKNIWIDGLGGDDNYILSTGFSKNnmreMKLWDLKnTTSALVTMSI--DNASApliPHYDES 273

                        170       180
                 ....*....|....*....|....*.
gi 23199987  179 GSLI-VSGSYDGLCRIWDAASGQCLK 203
Cdd:PTZ00420 274 TGLIyLIGKGDGNCRYYQHSLGSIRK 299
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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