NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|29789090|ref|NP_061185|]
View 

protein RCC2 [Homo sapiens]

Protein Classification

RCC1 domain-containing protein( domain architecture ID 11474102)

RCC1 (regulator of chromosome condensation) domain-containing protein similar to Arabidopsis UVR8 (UV RESISTANCE LOCUS 8), which plays an important role in mediating the effects of UV-B radiation on pathogen resistance by controlling the expression of the sinapate biosynthetic pathway.

Gene Ontology:  GO:0003682|GO:0005085
PubMed:  9510255|18442486

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 151-502 5.57e-53

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


:

Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 182.87  E-value: 5.57e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29789090 151 RTVVSGScaAHSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEGLSHevIVSAACGRNHTLALTETGSVFAFGENK 230
Cdd:COG5184   1 TQVAAGG--SHSCALKSDGTVWCWGDNSYGQLGDGTTTDRSTPVRVPGLSN--VVAVAAGGDHTCALKADGTVWCWGNNS 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29789090 231 MGQLGLGNqTDAVPSPAQIMYNGqPITKMACGAEFSMIMDCKGNLYSFGCPEYGQLGhnsDGKFIARaqrieydceLVPR 310
Cdd:COG5184  77 YGQLGDGT-TTDRTTPVKVPGLT-GVVAVAAGYYHSCALKSDGTVWCWGDNSSGQLG---DGTTTNR---------LTPV 142

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29789090 311 RVAIFIEKtkdgqilpvpnvvVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKLFDfpgrGASQIY 390
Cdd:COG5184 143 QVDAGLSG-------------VVAIAAGGYHTCALKSDGTVWCWGANSYGQLGDGTTTDRPTPVQVGGLS----GVVAVA 205

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29789090 391 AGYTCSFAVSEVGGLFFWGA---------TNTSREStmyPKAVQDLCGWriRSLACG-KSSIIVAADESTISWGpSPTFG 460
Cdd:COG5184 206 AGGDHSCALKSDGTVWCWGSnssgqlgdgTTTDRAT---PVQVAGLTGV--VAIAAGgSHTCALKSDGTVWCWG-DNSYG 279

                       330       340       350       360
                ....*....|....*....|....*....|....*....|..
gi 29789090 461 ELGYGDhkPKSSTAAQEVKTLDGIfsEQVAMGYSHSLVIARD 502
Cdd:COG5184 280 QLGDGT--TTDRSTPVKVPGLSGV--VAVAAGSSHTCALLTD 317
 
Name Accession Description Interval E-value
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 151-502 5.57e-53

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 182.87  E-value: 5.57e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29789090 151 RTVVSGScaAHSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEGLSHevIVSAACGRNHTLALTETGSVFAFGENK 230
Cdd:COG5184   1 TQVAAGG--SHSCALKSDGTVWCWGDNSYGQLGDGTTTDRSTPVRVPGLSN--VVAVAAGGDHTCALKADGTVWCWGNNS 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29789090 231 MGQLGLGNqTDAVPSPAQIMYNGqPITKMACGAEFSMIMDCKGNLYSFGCPEYGQLGhnsDGKFIARaqrieydceLVPR 310
Cdd:COG5184  77 YGQLGDGT-TTDRTTPVKVPGLT-GVVAVAAGYYHSCALKSDGTVWCWGDNSSGQLG---DGTTTNR---------LTPV 142

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29789090 311 RVAIFIEKtkdgqilpvpnvvVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKLFDfpgrGASQIY 390
Cdd:COG5184 143 QVDAGLSG-------------VVAIAAGGYHTCALKSDGTVWCWGANSYGQLGDGTTTDRPTPVQVGGLS----GVVAVA 205

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29789090 391 AGYTCSFAVSEVGGLFFWGA---------TNTSREStmyPKAVQDLCGWriRSLACG-KSSIIVAADESTISWGpSPTFG 460
Cdd:COG5184 206 AGGDHSCALKSDGTVWCWGSnssgqlgdgTTTDRAT---PVQVAGLTGV--VAIAAGgSHTCALKSDGTVWCWG-DNSYG 279

                       330       340       350       360
                ....*....|....*....|....*....|....*....|..
gi 29789090 461 ELGYGDhkPKSSTAAQEVKTLDGIfsEQVAMGYSHSLVIARD 502
Cdd:COG5184 280 QLGDGT--TTDRSTPVKVPGLSGV--VAVAAGSSHTCALLTD 317
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
168-217 6.60e-17

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 74.48  E-value: 6.60e-17
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 29789090   168 EGKLWSWGRNEKGQLGHGDTKRVEAPRLIEGLSHEVIVSAACGRNHTLAL 217
Cdd:pfam00415   1 DGRVYTWGRNDYGQLGLGTTENVLVPQKVEGLSGNKVVQVACGGDHTVAL 50
 
Name Accession Description Interval E-value
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 151-502 5.57e-53

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 182.87  E-value: 5.57e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29789090 151 RTVVSGScaAHSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEGLSHevIVSAACGRNHTLALTETGSVFAFGENK 230
Cdd:COG5184   1 TQVAAGG--SHSCALKSDGTVWCWGDNSYGQLGDGTTTDRSTPVRVPGLSN--VVAVAAGGDHTCALKADGTVWCWGNNS 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29789090 231 MGQLGLGNqTDAVPSPAQIMYNGqPITKMACGAEFSMIMDCKGNLYSFGCPEYGQLGhnsDGKFIARaqrieydceLVPR 310
Cdd:COG5184  77 YGQLGDGT-TTDRTTPVKVPGLT-GVVAVAAGYYHSCALKSDGTVWCWGDNSSGQLG---DGTTTNR---------LTPV 142

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29789090 311 RVAIFIEKtkdgqilpvpnvvVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKLFDfpgrGASQIY 390
Cdd:COG5184 143 QVDAGLSG-------------VVAIAAGGYHTCALKSDGTVWCWGANSYGQLGDGTTTDRPTPVQVGGLS----GVVAVA 205

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29789090 391 AGYTCSFAVSEVGGLFFWGA---------TNTSREStmyPKAVQDLCGWriRSLACG-KSSIIVAADESTISWGpSPTFG 460
Cdd:COG5184 206 AGGDHSCALKSDGTVWCWGSnssgqlgdgTTTDRAT---PVQVAGLTGV--VAIAAGgSHTCALKSDGTVWCWG-DNSYG 279

                       330       340       350       360
                ....*....|....*....|....*....|....*....|..
gi 29789090 461 ELGYGDhkPKSSTAAQEVKTLDGIfsEQVAMGYSHSLVIARD 502
Cdd:COG5184 280 QLGDGT--TTDRSTPVKVPGLSGV--VAVAAGSSHTCALLTD 317
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 150-409 1.04e-41

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 152.44  E-value: 1.04e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29789090 150 VRTVVSGscAAHSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIeGLSHEVIVSAACGRNHTLALTETGSVFAFGEN 229
Cdd:COG5184 100 VVAVAAG--YYHSCALKSDGTVWCWGDNSSGQLGDGTTTNRLTPVQV-DAGLSGVVAIAAGGYHTCALKSDGTVWCWGAN 176

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29789090 230 KMGQLGLGNQTDaVPSPAQIMyNGQPITKMACGAEFSMIMDCKGNLYSFGCPEYGQLGhnsDGKFIARAqrieydcelVP 309
Cdd:COG5184 177 SYGQLGDGTTTD-RPTPVQVG-GLSGVVAVAAGGDHSCALKSDGTVWCWGSNSSGQLG---DGTTTDRA---------TP 242

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29789090 310 RRVAifiektkdgqilpvPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKLFDfpgrGASQI 389
Cdd:COG5184 243 VQVA--------------GLTGVVAIAAGGSHTCALKSDGTVWCWGDNSYGQLGDGTTTDRSTPVKVPGLS----GVVAV 304

                       250       260
                ....*....|....*....|
gi 29789090 390 YAGYTCSFAVSEVGGLFFWG 409
Cdd:COG5184 305 AAGSSHTCALLTDGTVWCWG 324
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 150-373 7.81e-37

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 139.34  E-value: 7.81e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29789090 150 VRTVVSGScaAHSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEGLSHevIVSAACGRNHTLALTETGSVFAFGEN 229
Cdd:COG5184 151 VVAIAAGG--YHTCALKSDGTVWCWGANSYGQLGDGTTTDRPTPVQVGGLSG--VVAVAAGGDHSCALKSDGTVWCWGSN 226

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29789090 230 KMGQLGLGNQTDaVPSPAQIMyNGQPITKMACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSdgkfiaRAQRieydceLVP 309
Cdd:COG5184 227 SSGQLGDGTTTD-RATPVQVA-GLTGVVAIAAGGSHTCALKSDGTVWCWGDNSYGQLGDGT------TTDR------STP 292

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 29789090 310 RRVAifiektkdgqilPVPNVVvrDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVP 373
Cdd:COG5184 293 VKVP------------GLSGVV--AVAAGSSHTCALLTDGTVWCWGDNAYGQLGDGTTTDRSTP 342
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 146-244 5.88e-21

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 93.89  E-value: 5.88e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29789090 146 AGVRVRTVVSGScaAHSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEGLSHevIVSAACGRNHTLALTETGSVFA 225
Cdd:COG5184 247 GLTGVVAIAAGG--SHTCALKSDGTVWCWGDNSYGQLGDGTTTDRSTPVKVPGLSG--VVAVAAGSSHTCALLTDGTVWC 322

                        90       100
                ....*....|....*....|
gi 29789090 226 FGENKMGQLGLGNQTD-AVP 244
Cdd:COG5184 323 WGDNAYGQLGDGTTTDrSTP 342
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
168-217 6.60e-17

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 74.48  E-value: 6.60e-17
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 29789090   168 EGKLWSWGRNEKGQLGHGDTKRVEAPRLIEGLSHEVIVSAACGRNHTLAL 217
Cdd:pfam00415   1 DGRVYTWGRNDYGQLGLGTTENVLVPQKVEGLSGNKVVQVACGGDHTVAL 50
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
221-269 2.57e-09

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 52.90  E-value: 2.57e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 29789090   221 GSVFAFGENKMGQLGLGNQTDaVPSPAQIMY-NGQPITKMACGAEFSMIM 269
Cdd:pfam00415   2 GRVYTWGRNDYGQLGLGTTEN-VLVPQKVEGlSGNKVVQVACGGDHTVAL 50
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
350-399 3.58e-09

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 52.52  E-value: 3.58e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 29789090   350 RVFSWGFGGYGRLGHAEQKDEMVPRLVKLfdFPGRGASQIYAGYTCSFAV 399
Cdd:pfam00415   3 RVYTWGRNDYGQLGLGTTENVLVPQKVEG--LSGNKVVQVACGGDHTVAL 50
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
272-345 1.29e-08

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 50.98  E-value: 1.29e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 29789090   272 KGNLYSFGCPEYGQLGHNSDgkfiaraqrieyDCELVPRRVAIFiektkdgqilpvPNVVVRDVACGANHTLVL 345
Cdd:pfam00415   1 DGRVYTWGRNDYGQLGLGTT------------ENVLVPQKVEGL------------SGNKVVQVACGGDHTVAL 50
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
204-233 4.35e-08

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 48.96  E-value: 4.35e-08
                          10        20        30
                  ....*....|....*....|....*....|
gi 29789090   204 IVSAACGRNHTLALTETGSVFAFGENKMGQ 233
Cdd:pfam13540   1 VVSVAAGDNHTLALTSDGRVYCWGDNSYGQ 30
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
332-361 8.95e-07

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 45.11  E-value: 8.95e-07
                          10        20        30
                  ....*....|....*....|....*....|
gi 29789090   332 VRDVACGANHTLVLDSQKRVFSWGFGGYGR 361
Cdd:pfam13540   1 VVSVAAGDNHTLALTSDGRVYCWGDNSYGQ 30
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
150-181 1.20e-05

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 42.03  E-value: 1.20e-05
                          10        20        30
                  ....*....|....*....|....*....|..
gi 29789090   150 VRTVVSGScaAHSLLITTEGKLWSWGRNEKGQ 181
Cdd:pfam13540   1 VVSVAAGD--NHTLALTSDGRVYCWGDNSYGQ 30
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
256-285 9.01e-04

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 36.63  E-value: 9.01e-04
                          10        20        30
                  ....*....|....*....|....*....|
gi 29789090   256 ITKMACGAEFSMIMDCKGNLYSFGCPEYGQ 285
Cdd:pfam13540   1 VVSVAAGDNHTLALTSDGRVYCWGDNSYGQ 30
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH