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Conserved domains on  [gi|41349476|ref|NP_061169|]
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PR domain zinc finger protein 5 isoform 1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PR-SET_PRDM5 cd19190
PR-SET domain found in PR domain zinc finger protein 5 (PRDM5) and similar proteins; PRDM5 ...
 2-128 4.57e-97

PR-SET domain found in PR domain zinc finger protein 5 (PRDM5) and similar proteins; PRDM5 (also termed PR domain-containing protein 5) is a sequence-specific DNA-binding transcription factor that represses transcription at least in part by recruitment of the histone methyltransferase EHMT2/G9A and histone deacetylases such as HDAC1.


:

Pssm-ID: 380967  Cd Length: 127  Bit Score: 293.04  E-value: 4.57e-97
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41349476   2 LGMYVPDRFSLKSSRVQDGMGLYTARRVRKGEKFGPFAGEKRMPEDLDENMDYRLMWEVRGSKGEVLYILDATNPRHSNW 81
Cdd:cd19190   1 LGMYVPDRFSLKSSKVQDGMGLYTARRVKKGEKFGPFAGEKRMPNELDESMDPRLMWEVRGSKGEVLYILDASNPRHSNW 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 41349476  82 LRFVHEAPSQEQKNLAAIQEGENIFYLAVEDIETDTELLIGYLDSDM 128
Cdd:cd19190  81 LRFVHEAPSQEQKNLAAIQEGENIFYLAVDDIETDTELLIGYLDSDM 127
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
262-620 2.05e-07

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 53.93  E-value: 2.05e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41349476 262 FVCKADSCGKRLKSKDALKRHQENVHTG--DPKKKLICSVCNKKCSSASSLQ-EHRKIHEifDCQECMKKFISANQLKRH 338
Cdd:COG5048  62 SQCSYSGCDKSFSRPLELSRHLRTHHNNpsDLNSKSLPLSNSKASSSSLSSSsSNSNDNN--LLSSHSLPPSSRDPQLPD 139

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41349476 339 MITHSEKRPYNCEICNKSFKRLDQ---------VGAHKVIHSEDK----------PYKCKLCGKGFAHRNVYKNHKKTHS 399
Cdd:COG5048 140 LLSISNLRNNPLPGNNSSSVNTPQsnslhpplpANSLSKDPSSNLsllissnvstSIPSSSENSPLSSSYSIPSSSSDQN 219

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41349476 400 EER---PFQCEECKALFRTPFSLQRHLLIHNSERTFKCHHCDATFKRKDTLNVHVQVVHE------RHKKYRCELCNKAF 470
Cdd:COG5048 220 LENsssSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDsssekgFSLPIKSKQCNISF 299

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41349476 471 VTPSVLRSHKKT--HTGE--KEKICPY--CGQKFASSGTLRVHIRSHTGERPYQCPYCEKGFSKNDGLKMHIRTHTREKP 544
Cdd:COG5048 300 SRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLNNEPPQSLQQYK 379

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41349476 545 YKC---------SECSKAFSQKRGLDEHKRTHTGEKP--FQCDVCDLAFSLKKMLIRHKMTHNPNRPLaeCQFCHKKFTR 613
Cdd:COG5048 380 DLKndkksetlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPL--LCSILKSFRR 457


                ....*..
gi 41349476 614 NDYLKVH 620
Cdd:COG5048 458 DLDLSNH 464
SUF4-like super family cl41227
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 172-220 5.14e-04

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


The actual alignment was detected with superfamily member cd20908:

Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 39.08  E-value: 5.14e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*....
gi 41349476 172 CESSFTSEDILaehlqTLHQKpteEKEFKCKNCGKKFPVKQALQRHVLQ 220
Cdd:cd20908   7 CDREFDDEKIL-----IQHQK---AKHFKCHICHKKLYTAGGLAVHCLQ 47
 
Name Accession Description Interval E-value
PR-SET_PRDM5 cd19190
PR-SET domain found in PR domain zinc finger protein 5 (PRDM5) and similar proteins; PRDM5 ...
 2-128 4.57e-97

PR-SET domain found in PR domain zinc finger protein 5 (PRDM5) and similar proteins; PRDM5 (also termed PR domain-containing protein 5) is a sequence-specific DNA-binding transcription factor that represses transcription at least in part by recruitment of the histone methyltransferase EHMT2/G9A and histone deacetylases such as HDAC1.


Pssm-ID: 380967  Cd Length: 127  Bit Score: 293.04  E-value: 4.57e-97
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41349476   2 LGMYVPDRFSLKSSRVQDGMGLYTARRVRKGEKFGPFAGEKRMPEDLDENMDYRLMWEVRGSKGEVLYILDATNPRHSNW 81
Cdd:cd19190   1 LGMYVPDRFSLKSSKVQDGMGLYTARRVKKGEKFGPFAGEKRMPNELDESMDPRLMWEVRGSKGEVLYILDASNPRHSNW 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 41349476  82 LRFVHEAPSQEQKNLAAIQEGENIFYLAVEDIETDTELLIGYLDSDM 128
Cdd:cd19190  81 LRFVHEAPSQEQKNLAAIQEGENIFYLAVDDIETDTELLIGYLDSDM 127
SET smart00317
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ...
 20-130 1.67e-07

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues


Pssm-ID: 214614 [Multi-domain]  Cd Length: 124  Bit Score: 50.41  E-value: 1.67e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41349476     20 GMGLYTARRVRKGEKFGPFAGEKRMPEDLDENMDY--------RLMWEVRGSkgevlYILDATnpRHSNWLRFV-HEAPS 90
Cdd:smart00317  12 GWGVRATEDIPKGEFIGEYVGEIITSEEAEERPKAydtdgakaFYLFDIDSD-----LCIDAR--RKGNLARFInHSCEP 84

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 41349476     91 QEQkNLAAIQEGENIFYL-AVEDIETDTELLIGYLDSDMEA 130
Cdd:smart00317  85 NCE-LLFVEVNGDDRIVIfALRDIKPGEELTIDYGSDYANE 124
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
262-620 2.05e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 53.93  E-value: 2.05e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41349476 262 FVCKADSCGKRLKSKDALKRHQENVHTG--DPKKKLICSVCNKKCSSASSLQ-EHRKIHEifDCQECMKKFISANQLKRH 338
Cdd:COG5048  62 SQCSYSGCDKSFSRPLELSRHLRTHHNNpsDLNSKSLPLSNSKASSSSLSSSsSNSNDNN--LLSSHSLPPSSRDPQLPD 139

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41349476 339 MITHSEKRPYNCEICNKSFKRLDQ---------VGAHKVIHSEDK----------PYKCKLCGKGFAHRNVYKNHKKTHS 399
Cdd:COG5048 140 LLSISNLRNNPLPGNNSSSVNTPQsnslhpplpANSLSKDPSSNLsllissnvstSIPSSSENSPLSSSYSIPSSSSDQN 219

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41349476 400 EER---PFQCEECKALFRTPFSLQRHLLIHNSERTFKCHHCDATFKRKDTLNVHVQVVHE------RHKKYRCELCNKAF 470
Cdd:COG5048 220 LENsssSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDsssekgFSLPIKSKQCNISF 299

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41349476 471 VTPSVLRSHKKT--HTGE--KEKICPY--CGQKFASSGTLRVHIRSHTGERPYQCPYCEKGFSKNDGLKMHIRTHTREKP 544
Cdd:COG5048 300 SRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLNNEPPQSLQQYK 379

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41349476 545 YKC---------SECSKAFSQKRGLDEHKRTHTGEKP--FQCDVCDLAFSLKKMLIRHKMTHNPNRPLaeCQFCHKKFTR 613
Cdd:COG5048 380 DLKndkksetlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPL--LCSILKSFRR 457


                ....*..
gi 41349476 614 NDYLKVH 620
Cdd:COG5048 458 DLDLSNH 464
SET pfam00856
SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ...
 20-123 1.43e-06

SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure.


Pssm-ID: 459965 [Multi-domain]  Cd Length: 115  Bit Score: 47.52  E-value: 1.43e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41349476    20 GMGLYTARRVRKGEKFGPFAGEKRM-PEDLDENMDYRLMWEVRGSKGEVL--------YILDATNPRHSNWLRFV-HEAP 89
Cdd:pfam00856   1 GRGLFATEDIPKGEFIGEYVEVLLItKEEADKRELLYYDKLELRLWGPYLftldedseYCIDARALYYGNWARFInHSCD 80

                          90       100       110
                  ....*....|....*....|....*....|....
gi 41349476    90 SQEQKNLAAIQEGENIFYLAVEDIETDTELLIGY 123
Cdd:pfam00856  81 PNCEVRVVYVNGGPRIVIFALRDIKPGEELTIDY 114
zf-H2C2_2 pfam13465
Zinc-finger double domain;
532-556 2.38e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 2.38e-04
                          10        20
                  ....*....|....*....|....*
gi 41349476   532 LKMHIRTHTREKPYKCSECSKAFSQ 556
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 172-220 5.14e-04

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 39.08  E-value: 5.14e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*....
gi 41349476 172 CESSFTSEDILaehlqTLHQKpteEKEFKCKNCGKKFPVKQALQRHVLQ 220
Cdd:cd20908   7 CDREFDDEKIL-----IQHQK---AKHFKCHICHKKLYTAGGLAVHCLQ 47
PHA00733 PHA00733
hypothetical protein
 490-536 1.49e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 39.09  E-value: 1.49e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 41349476  490 ICPYCGQKFASSGTLRVHIRshTGERPYQCPYCEKGFSKNDGLKMHI 536
Cdd:PHA00733  75 VCPLCLMPFSSSVSLKQHIR--YTEHSKVCPVCGKEFRNTDSTLDHV 119
 
Name Accession Description Interval E-value
PR-SET_PRDM5 cd19190
PR-SET domain found in PR domain zinc finger protein 5 (PRDM5) and similar proteins; PRDM5 ...
 2-128 4.57e-97

PR-SET domain found in PR domain zinc finger protein 5 (PRDM5) and similar proteins; PRDM5 (also termed PR domain-containing protein 5) is a sequence-specific DNA-binding transcription factor that represses transcription at least in part by recruitment of the histone methyltransferase EHMT2/G9A and histone deacetylases such as HDAC1.


Pssm-ID: 380967  Cd Length: 127  Bit Score: 293.04  E-value: 4.57e-97
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41349476   2 LGMYVPDRFSLKSSRVQDGMGLYTARRVRKGEKFGPFAGEKRMPEDLDENMDYRLMWEVRGSKGEVLYILDATNPRHSNW 81
Cdd:cd19190   1 LGMYVPDRFSLKSSKVQDGMGLYTARRVKKGEKFGPFAGEKRMPNELDESMDPRLMWEVRGSKGEVLYILDASNPRHSNW 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 41349476  82 LRFVHEAPSQEQKNLAAIQEGENIFYLAVEDIETDTELLIGYLDSDM 128
Cdd:cd19190  81 LRFVHEAPSQEQKNLAAIQEGENIFYLAVDDIETDTELLIGYLDSDM 127
PR-SET_PRDM2 cd19188
PR-SET domain found in PR domain zinc finger protein 2 (PRDM2) and similar proteins; PRDM2 ...
 3-127 7.58e-27

PR-SET domain found in PR domain zinc finger protein 2 (PRDM2) and similar proteins; PRDM2 (also termed GATA-3-binding protein G3B, lysine N-methyltransferase 8, MTB-or MTE-binding protein, PR domain-containing protein 2, retinoblastoma protein-interacting zinc finger protein, or zinc finger protein RIZ) is S-adenosyl-L-methionine-dependent histone methyltransferase that specifically methylates 'Lys-9' of histone H3. It may function as a DNA-binding transcription factor.


Pssm-ID: 380965  Cd Length: 123  Bit Score: 105.60  E-value: 7.58e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41349476   3 GMYVPDRFSLKSSRVQDG-MGLYTARRVRKGEKFGPFAGEKRMPEDLDENmDYrlMWEVRGSKGEvLYILDATNPRHSNW 81
Cdd:cd19188   1 LMGLPEELELKPSAVDKTrIGVWAKKSIPKGRKFGPFVGEKKKRSQVKNN-VY--MWEIYGPKRG-WMCVDASDPTKGNW 76

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 41349476  82 LRFVHEAPSQEQKNLAAIQEGENIFYLAVEDIETDTELLIGYLDSD 127
Cdd:cd19188  77 LRYVNWARSGEEQNLFPLQINRAIYYKTLKPIAPGEELLCWYNGED 122
PR-SET_PRDM16_PRDM3 cd19200
PR-SET domain found in PR domain zinc finger protein 16 (PRDM16), MDS1 and EVI1 complex locus ...
 6-133 3.69e-25

PR-SET domain found in PR domain zinc finger protein 16 (PRDM16), MDS1 and EVI1 complex locus protein and similar proteins; PRDM16 (also termed PR domain-containing protein 16, transcription factor MEL1, or MDS1/EVI1-like gene 1) functions as a transcriptional regulator. PRDM16 is preferentially expressed by hematopoietic and neuronal stem cells. It is closely related to paralog of PRDM3 (also termed MDS1 and EVI1 complex locus protein, ecotropic virus integration site 1 protein, EVI-1, myelodysplasia syndrome 1 protein, myelodysplasia syndrome-associated protein 1, or MECOM) which is a nuclear transcription factor essential for the proliferation/maintenance of hematopoietic stem cells (HSCs). PRDM3 and PRDM16 are both directly linked to various aspects of oncogenic transformation.


Pssm-ID: 380977  Cd Length: 135  Bit Score: 101.29  E-value: 3.69e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41349476   6 VPDRFSLKSSRVQ-DGMGLYTARRVRKGEKFGPFAGEKRmpeDLDENMDYRlmWEVRGSKGEVLYILDATNPRHSNWLRF 84
Cdd:cd19200  10 IPPDFELRESAAVgAGLGVWTKVRIEVGEKFGPFVGVQR---SSVKDPTYA--WEIVDEFGKVKFWIDASEPGTGNWMKY 84

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 41349476  85 VHEAPSQEQKNLAAIQEGENIFYLAVEDIETDTELLIgYLDSDMEAEEE 133
Cdd:cd19200  85 IRSAPSCEQQNLMACQIDEQIYYKVVRDIQPGEELLL-YMKAAVYPHET 132
PR-SET_PRDM12 cd19196
PR-SET domain found in PR domain zinc finger protein 12 (PRDM12) and similar proteins; PRDM12 ...
 6-123 2.44e-24

PR-SET domain found in PR domain zinc finger protein 12 (PRDM12) and similar proteins; PRDM12 (also termed PR domain-containing protein 12) acts as a transcription factor that is involved in the positive regulation of histone H3-K9 dimethylation.


Pssm-ID: 380973 [Multi-domain]  Cd Length: 130  Bit Score: 98.58  E-value: 2.44e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41349476   6 VPDRFSLKSSRVQ-DGMGLYTARRVRKGEKFGPFAGEKRMPEDLDENMDYRLMWEVRGSKGEVLYILDATNPRHSNWLRF 84
Cdd:cd19196   1 LPSQVIIAQSSIPgAGLGVFSKTWIKEGTEMGPYTGRIVSPEDVDPCKNNNLMWEVFNEDGTVSHFIDASQENHRSWMTF 80

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 41349476  85 VHEAPSQEQKNLAAIQEGENIFYLAVEDIETDTELLIGY 123
Cdd:cd19196  81 VNCARNEQEQNLEVVQIGESIYYRAIKDIPPDQELLVWY 119
PR-SET_PRDM7_9 cd19193
PR-SET domain found in PR domain zinc finger protein 7 (PRDM7) and 9 (PRDM9) and similar ...
 6-126 1.02e-22

PR-SET domain found in PR domain zinc finger protein 7 (PRDM7) and 9 (PRDM9) and similar proteins; PRDM7 (also termed PR domain-containing protein 7) is a primate-specific histone methyltransferase that is the result of a recent gene duplication of PRDM9. It selectively catalyzes the trimethylation of H3 lysine 4 (H3K4me3). PRDM9 (also termed PR domain-containing protein 9) is a histone methyltransferase that specifically trimethylates 'Lys-4' of histone H3 (H3K4me3) during meiotic prophase and is essential for proper meiotic progression. It also efficiently mono-, di-, and trimethylates H3K36. Aberrant PRDM9 expression is assciated with with genome instability in cancer.


Pssm-ID: 380970 [Multi-domain]  Cd Length: 129  Bit Score: 93.84  E-value: 1.02e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41349476   6 VPDRFSLKSSRVQD-GMGLYTARRVRKGEKFGPFAGEKRMPEDLDENMdYrlMWEVRGSKGEVLYIlDATNPRHSNWLRF 84
Cdd:cd19193   4 LPPGLSIKRSSIPGaGLGVWAEAPIPKGMVFGPYEGEIVEDEEAADSG-Y--SWQIYKGGKLSHYI-DAKDESKSNWMRY 79

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 41349476  85 VHEAPSQEQKNLAAIQEGENIFYLAVEDIETDTELLIGYLDS 126
Cdd:cd19193  80 VNCARNEEEQNLVAFQYRGKIYYRTCKDIAPGTELLVWYGDE 121
PR-SET_PRDM1 cd19187
PR-SET domain found in PR domain zinc finger protein 1 (PRDM1) and similar proteins; PRDM1 ...
 7-123 6.06e-22

PR-SET domain found in PR domain zinc finger protein 1 (PRDM1) and similar proteins; PRDM1 (also termed BLIMP-1, beta-interferon gene positive regulatory domain I-binding factor, PR domain-containing protein 1, positive regulatory domain I-binding factor 1, PRDI-BF1, or PRDI-binding factor 1) acts as a transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs.


Pssm-ID: 380964 [Multi-domain]  Cd Length: 128  Bit Score: 91.62  E-value: 6.06e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41349476   7 PDRFSLKSSRVQ-DGMGLYTARRVRKGEKFGPFAGEKRMPEDLDENMDYRLMWEVRGSKGEVLYIlDATNPRHSNWLRFV 85
Cdd:cd19187   4 PRNLTLKYSSVGrEVLGVWSSDYIPRGTRFGPLVGEIYTNDPVPKGANRKYFWRIYSNGEFYHYI-DGFDPSKSNWMRYV 82

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 41349476  86 HEAPSQEQKNLAAIQEGENIFYLAVEDIETDTELLIGY 123
Cdd:cd19187  83 NPAHSLQEQNLVACQIGMNIYFYTVKPIPPNQELLVWY 120
PR-SET_PRDM3 cd19214
PR-SET domain found in MDS1 and EVI1 complex locus protein and similar proteins; PRDM3 (also ...
 6-138 1.11e-21

PR-SET domain found in MDS1 and EVI1 complex locus protein and similar proteins; PRDM3 (also termed MDS1 and EVI1 complex locus protein, ecotropic virus integration site 1 protein, EVI-1, myelodysplasia syndrome 1 protein, myelodysplasia syndrome-associated protein 1, or MECOM) is a nuclear transcription factor, which is essential for the proliferation/maintenance of hematopoietic stem cells (HSCs). It is closely related to paralog PRDM16, both o fwhich are directly linked to various aspects of oncogenic transformation.


Pssm-ID: 380991  Cd Length: 158  Bit Score: 91.92  E-value: 1.11e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41349476   6 VPDRFSLKSSRVQD-GMGLYTARRVRKGEKFGPFAGEKRMPEDldenmDYRLMWEVRGSKGEVLYILDATNPRHSNWLRF 84
Cdd:cd19214  30 IPSEFELRESNIPGtGLGIWTKRKIEVGEKFGPYVGEQRSNLK-----DPSYGWEVLDEFGNVKFCIDASQPDVGSWLKY 104

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 41349476  85 VHEAPSQEQKNLAAIQEGENIFYLAVEDIETDTELLIGyldsdMEAEEEEQQIM 138
Cdd:cd19214 105 IRFAGCYDQHNLVACQINDQIFYRAVADIDPGEELLLF-----MKSEDYSHETM 153
PR-SET_PRDM6 cd19191
PR-SET domain found in PR domain zinc finger protein 6 (PRDM6) and similar proteins; PRDM6 ...
 7-126 1.79e-19

PR-SET domain found in PR domain zinc finger protein 6 (PRDM6) and similar proteins; PRDM6 (also termed PR domain-containing protein 6) is a putative histone-lysine N-methyltransferase that acts as a transcriptional repressor of smooth muscle gene expression. It may specifically methylate 'Lys-20' of histone H4 when associated with other proteins and in vitro.


Pssm-ID: 380968  Cd Length: 128  Bit Score: 84.84  E-value: 1.79e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41349476   7 PDRFSL-KSSRVQDGMGLYTARRVRKGEKFGPFAGEKRMPEDLDENM-DYRLMWEVRGSKGEVLYILDATNPRHSNWLRF 84
Cdd:cd19191   2 PDEVCLcTSSIPGLGYGICAAQRIPQGTWIGPFEGVLVSPEKQIGAVrNTQHLWEIYDQEGTLQHFIDGGDPSKSSWMRY 81

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 41349476  85 VHEAPSQEQKNLAAIQEGENIFYLAVEDIETDTELLIGYLDS 126
Cdd:cd19191  82 IRCARHCGEQNLTVVQYRGCIFYRACRDIPRGTELLVWYDDS 123
PR-SET_PRDM-like cd10534
PR-SET domain found in PRDM (PRDI-BF1 and RIZ homology domain) family of proteins; PRDM family ...
 6-123 1.31e-18

PR-SET domain found in PRDM (PRDI-BF1 and RIZ homology domain) family of proteins; PRDM family of proteins is defined based on the conserved N-terminal PR domain, which is closely related to the Su(var)3-9, enhancer of zeste, and trithorax (SET) domains of histone methyltransferases, and is specifically called PR-SET domain. The family consists of 17 members in primates. PRDMs play diverse roles in cell-cycle regulation, differentiation, and meiotic recombination. The family also contains zinc finger protein ZFPM1 and ZFPM2. ZFPM1 (also termed friend of GATA protein 1, FOG-1, friend of GATA 1, zinc finger protein 89A, or zinc finger protein multitype 1) functions as a transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. ZFPM2 (also termed friend of GATA protein 2, FOG-2, friend of GATA 2, zinc finger protein 89B, or zinc finger protein multitype 2) functions as a transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis.


Pssm-ID: 380932  Cd Length: 83  Bit Score: 80.70  E-value: 1.31e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41349476   6 VPDRFSL-KSSRVQDGMGLYTARRVRKGEKFGPFAGEKrmpedldenmdyrlmwevrgskgevlyildatnprhsNWLRF 84
Cdd:cd10534   1 LPAGLELvLSSIPEGGLGVFARRTIPAGTRFGPLEGVV-------------------------------------NWMRF 43

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 41349476  85 VHEAPSQEQKNLAAIQEGENIFYLAVEDIETDTELLIGY 123
Cdd:cd10534  44 VRPARNEEEQNLVAYQHGGQIYFRTTRDIPPGEELLVWY 82
PR-SET_PRDM16 cd19213
PR-SET domain found in PR domain zinc finger protein 16 (PRDM16) and similar proteins; PRDM16, ...
 6-128 3.08e-16

PR-SET domain found in PR domain zinc finger protein 16 (PRDM16) and similar proteins; PRDM16, also termed PR domain-containing protein 16, or transcription factor MEL1, or MDS1/EVI1-like gene 1, functions as a transcriptional regulator. PRDM16 is preferentially expressed by hematopoietic and neuronal stem cells and is closely related to paralog of PRDM3, both of which are directly linked to various aspects of oncogenic transformation.


Pssm-ID: 380990  Cd Length: 162  Bit Score: 76.45  E-value: 3.08e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41349476   6 VPDRFSLKSSRVQD-GMGLYTARRVRKGEKFGPFAGEKRMP------------EDLDENMDYRLMWEVRGSKGEVLYILD 72
Cdd:cd19213  20 IPSDFELRESSIPGaGLGVWAKRKIEAGERFGPYTGVQRSTlkdtnfgweqilNDVEVSSQEGCITKIVDDLGNEKFCVD 99

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 41349476  73 ATNPRHSNWLRFVHEAPSQEQKNLAAIQEGENIFYLAVEDIETDTELLI-----GYLDSDM 128
Cdd:cd19213 100 AGQAGAGSWLKYIRVACSCDEQNLTACQINEQIYYKVIKDIEPGEELLVyvkdgVYPLGTM 160
PR-SET_PRDM14 cd19198
PR-SET domain found in PR domain zinc finger protein 14 (PRDM14) and similar proteins; PRDM14 ...
 22-125 9.21e-15

PR-SET domain found in PR domain zinc finger protein 14 (PRDM14) and similar proteins; PRDM14 (also termed PR domain-containing protein 14) acts as a transcription factor that has both positive and negative roles on transcription. It acts on regulating epigenetic modifications in the cells, playing a key role in the regulation of cell pluripotency, epigenetic reprogramming, differentiation and development. Aberrant PRDM14 expression is associated with tumorigenesis, cell migration and cell chemotherapeutic drugs resistance.


Pssm-ID: 380975  Cd Length: 133  Bit Score: 71.28  E-value: 9.21e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41349476  22 GLYTARRVRKGEKFGPFAGEKRMPEDLDENMDYRLMWEVRgSKGEVLYILDAtNPRHSNWLRFVHEAPSQEQKNLAAIQE 101
Cdd:cd19198  21 GVFCKKTIPKGTRFGPFRGRVVNTSEIKTYDDNSFMWEIF-EDGKLSHFIDG-RGSTGNWMSYVNCARYAEEQNLIAIQC 98

                        90       100
                ....*....|....*....|....
gi 41349476 102 GENIFYLAVEDIETDTELLIGYLD 125
Cdd:cd19198  99 QGQIFYESCKEILQGQELLVWYGD 122
PR-SET_ZFPM cd19201
PR-SET domain found in zinc finger protein ZFPM1, ZFPM2 and similar proteins; ZFPM1 (also ...
 22-127 1.14e-14

PR-SET domain found in zinc finger protein ZFPM1, ZFPM2 and similar proteins; ZFPM1 (also termed friend of GATA protein 1, FOG-1, friend of GATA 1, zinc finger protein 89A, or zinc finger protein multitype 1) functions as a transcription regulator that plays an essential role in erythroid and megakaryocytic cell differentiation. ZFPM2 (also termed friend of GATA protein 2, FOG-2, friend of GATA 2, zinc finger protein 89B, or zinc finger protein multitype 2) functions as a transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis.


Pssm-ID: 380978  Cd Length: 122  Bit Score: 70.84  E-value: 1.14e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41349476  22 GLYTARRVRKGEKFGPFAGekRMpEDLDENMDYRLMWEVRGSKGEVLYILDATNPrhSNWLRFVHEAPSQEQKNLAAIQE 101
Cdd:cd19201  21 GVWAKQPLPEGTRFGPYPG--KL-VKEPLDPSYEWKVEAQGSKGGEGLLLLTEDS--GTWLKLVRSADDEDEANLILYFK 95

                        90       100
                ....*....|....*....|....*.
gi 41349476 102 GENIFYLAVEDIETDTELLIGYLDSD 127
Cdd:cd19201  96 GGQIWCEVTKDIPPGEELILVLREPL 121
PR-SET_PRDM10 cd19194
PR-SET domain found in PR domain zinc finger protein 10 (PRDM10) and similar proteins; PRDM10 ...
 22-123 8.20e-13

PR-SET domain found in PR domain zinc finger protein 10 (PRDM10) and similar proteins; PRDM10 (also termed PR domain-containing protein 10, or tristanin) may be involved in transcriptional regulation.


Pssm-ID: 380971  Cd Length: 128  Bit Score: 65.45  E-value: 8.20e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41349476  22 GLYTARRVRKGEKFGPFAGEkrMPEDLDENMDYRLMWEVRGSKGEVLYIlDATNPRHSNWLRFVHEAPSQEQKNLAAIQE 101
Cdd:cd19194  21 GVFAKRRIPKRTQFGPLEGP--LVKKSELKDNKIHPLELEEDDGEDLYF-DLSDENKCNWMMFVRPAQNHLEQNLVAYQY 97

                        90       100
                ....*....|....*....|..
gi 41349476 102 GENIFYLAVEDIETDTELLIGY 123
Cdd:cd19194  98 GQEIYFTTIKNIEPKQELKVWY 119
PR-SET_PRDM4 cd19189
PR-SET domain found in PR domain zinc finger protein 4 (PRDM4) and similar proteins; PRDM4 ...
 4-123 9.55e-13

PR-SET domain found in PR domain zinc finger protein 4 (PRDM4) and similar proteins; PRDM4 (also termed PR domain-containing protein 4, or PFM1) may function as a transcription factor involved in cell differentiation.


Pssm-ID: 380966  Cd Length: 133  Bit Score: 65.56  E-value: 9.55e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41349476   4 MYVPDRFSLKSSRVQDGMGLYTARRVRKGEKFGPFAGEKRMPEDLDENMDYRL--MWEVRgSKGEVLYILDATNPRHSNW 81
Cdd:cd19189   4 LSLPRQLYLRQSETGAEVGVWTKETIPVRTCFGPLIGQQSHSAEVADWTDKAAphIWKIY-HNDVLEFCIITTDENECNW 82

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 41349476  82 LRFVHEAPSQEQKNLAAIQEGENIFYLAVEDIETDTELLIGY 123
Cdd:cd19189  83 MMFVRKARTREEQNLVAYPHDGKIYFCTSRDIPPDQELLFYY 124
PR-SET_PRDM15 cd19199
PR-SET domain found in PR domain zinc finger protein 15 (PRDM15) and similar proteins; PRDM15 ...
 11-123 7.47e-09

PR-SET domain found in PR domain zinc finger protein 15 (PRDM15) and similar proteins; PRDM15 (also termed PR domain-containing protein 15, or zinc finger protein 298 (ZNF298)) may be involved in transcriptional regulation. It plays an essential role as a chromatin factor that modulates the transcription of upstream regulators of WNT and MAPK-ERK signaling to safeguard naive pluripotency.


Pssm-ID: 380976  Cd Length: 126  Bit Score: 54.34  E-value: 7.47e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41349476  11 SLKSSRVQDGM-GLYTARRVRKGEKFGPFAGEK--RMPEdldENMDYRLMWEVRGSkgevLYILDATNPRHSNWLRFVHE 87
Cdd:cd19199  10 NLEIRQLEDGSeGVFALVPLVKRTQFGPFEAKRvaRLDG---FAVFPLKVFEKDGS----VVYLDTSNEDDCNWMMFVRP 82

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 41349476  88 APSQEQKNLAAIQEGENIFYLAVEDIETDTELLIGY 123
Cdd:cd19199  83 ATDVEHQNLTAYQQGEDIYFTTSRDIQPGAELRVWY 118
SET smart00317
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ...
 20-130 1.67e-07

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues


Pssm-ID: 214614 [Multi-domain]  Cd Length: 124  Bit Score: 50.41  E-value: 1.67e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41349476     20 GMGLYTARRVRKGEKFGPFAGEKRMPEDLDENMDY--------RLMWEVRGSkgevlYILDATnpRHSNWLRFV-HEAPS 90
Cdd:smart00317  12 GWGVRATEDIPKGEFIGEYVGEIITSEEAEERPKAydtdgakaFYLFDIDSD-----LCIDAR--RKGNLARFInHSCEP 84

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 41349476     91 QEQkNLAAIQEGENIFYL-AVEDIETDTELLIGYLDSDMEA 130
Cdd:smart00317  85 NCE-LLFVEVNGDDRIVIfALRDIKPGEELTIDYGSDYANE 124
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
262-620 2.05e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 53.93  E-value: 2.05e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41349476 262 FVCKADSCGKRLKSKDALKRHQENVHTG--DPKKKLICSVCNKKCSSASSLQ-EHRKIHEifDCQECMKKFISANQLKRH 338
Cdd:COG5048  62 SQCSYSGCDKSFSRPLELSRHLRTHHNNpsDLNSKSLPLSNSKASSSSLSSSsSNSNDNN--LLSSHSLPPSSRDPQLPD 139

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41349476 339 MITHSEKRPYNCEICNKSFKRLDQ---------VGAHKVIHSEDK----------PYKCKLCGKGFAHRNVYKNHKKTHS 399
Cdd:COG5048 140 LLSISNLRNNPLPGNNSSSVNTPQsnslhpplpANSLSKDPSSNLsllissnvstSIPSSSENSPLSSSYSIPSSSSDQN 219

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41349476 400 EER---PFQCEECKALFRTPFSLQRHLLIHNSERTFKCHHCDATFKRKDTLNVHVQVVHE------RHKKYRCELCNKAF 470
Cdd:COG5048 220 LENsssSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDsssekgFSLPIKSKQCNISF 299

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41349476 471 VTPSVLRSHKKT--HTGE--KEKICPY--CGQKFASSGTLRVHIRSHTGERPYQCPYCEKGFSKNDGLKMHIRTHTREKP 544
Cdd:COG5048 300 SRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLNNEPPQSLQQYK 379

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41349476 545 YKC---------SECSKAFSQKRGLDEHKRTHTGEKP--FQCDVCDLAFSLKKMLIRHKMTHNPNRPLaeCQFCHKKFTR 613
Cdd:COG5048 380 DLKndkksetlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPL--LCSILKSFRR 457


                ....*..
gi 41349476 614 NDYLKVH 620
Cdd:COG5048 458 DLDLSNH 464
PR-SET_PRDM13 cd19197
PR-SET domain found in PR domain zinc finger protein 13 (PRDM13) and similar proteins; PRDM13 ...
 32-123 4.22e-07

PR-SET domain found in PR domain zinc finger protein 13 (PRDM13) and similar proteins; PRDM13 (also termed PR domain-containing protein 13) may be involved in transcriptional regulation. It mediates the balance of inhibitory and excitatory neurons in somatosensory circuits.


Pssm-ID: 380974  Cd Length: 103  Bit Score: 48.66  E-value: 4.22e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41349476  32 GEKFGPFAGEKRMPEDLDENMDYRLMWEVRGSKGEvlYILDATNPRHSNWLRFVHEAPSQEQKNLAAIQE--GENIFYLA 109
Cdd:cd19197   4 GLRLGPVPGIFKLGKYLSDRKEPGNKKKVRRVRGD--YLVDESGSPATEWIGLVRAARNNQEQNLEAIADlpGGQIFYRA 81

                        90
                ....*....|....
gi 41349476 110 VEDIETDTELLIGY 123
Cdd:cd19197  82 LRDIQPGEELTVWY 95
SET pfam00856
SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ...
 20-123 1.43e-06

SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure.


Pssm-ID: 459965 [Multi-domain]  Cd Length: 115  Bit Score: 47.52  E-value: 1.43e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41349476    20 GMGLYTARRVRKGEKFGPFAGEKRM-PEDLDENMDYRLMWEVRGSKGEVL--------YILDATNPRHSNWLRFV-HEAP 89
Cdd:pfam00856   1 GRGLFATEDIPKGEFIGEYVEVLLItKEEADKRELLYYDKLELRLWGPYLftldedseYCIDARALYYGNWARFInHSCD 80

                          90       100       110
                  ....*....|....*....|....*....|....
gi 41349476    90 SQEQKNLAAIQEGENIFYLAVEDIETDTELLIGY 123
Cdd:pfam00856  81 PNCEVRVVYVNGGPRIVIFALRDIKPGEELTIDY 114
PR-SET_PRDM11 cd19195
PR-SET domain found in PR domain zinc finger protein 11 (PRDM11) and similar proteins; PRDM11 ...
 29-129 7.54e-06

PR-SET domain found in PR domain zinc finger protein 11 (PRDM11) and similar proteins; PRDM11 (also termed PR domain-containing protein 11) may be involved in transcription regulation.


Pssm-ID: 380972  Cd Length: 127  Bit Score: 45.62  E-value: 7.54e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41349476  29 VRKGEKFGPFAGEKrMPED----------LDENMDYRLmwevrgskgevlyiLDATNPRHSNWLRFVHEAPSQEQKNLAA 98
Cdd:cd19195  28 IPKGHIFGPYEGQI-CTQDkssgffswliVDKNNRYKS--------------IDGSDETKANWMRYVVISREEREQNLLA 92

                        90       100       110
                ....*....|....*....|....*....|.
gi 41349476  99 IQEGENIFYLAVEDIETDTELLIGYLDSDME 129
Cdd:cd19195  93 FQHSEQIYFRACRDIRPGEKLRVWYSEDYMK 123
PR-SET_PRDM17 cd10520
PR-SET domain found in PR domain zinc finger protein 17 (PRDM17) and similar proteins; PRDM17 ...
 6-121 7.65e-06

PR-SET domain found in PR domain zinc finger protein 17 (PRDM17) and similar proteins; PRDM17 (also termed zinc finger protein 408 (ZNF408)) may be involved in transcriptional regulation.


Pssm-ID: 380918  Cd Length: 121  Bit Score: 45.49  E-value: 7.65e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41349476   6 VPDRFSLKSSRVQD-GMGLY-TARRVRKGEKFGPFAGEKrMPEDLDENMDYRLmwEVRGSKGEVLYILDAtnprhSNWLR 83
Cdd:cd10520   5 LPPGLALGPSLAQEeRLGVWcVGDALQKGTFLGPLEEEL-ESHDLTEGGSPRQ--EESGQSGDVLACEQS-----SKWMR 76

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 41349476  84 FVHEAPSQEQKNLAAIQEGENIFYLAVEDIETDTELLI 121
Cdd:cd10520  77 FACRARSEEESNVAVVRLSGRLHLRVCKDIEPGSELLL 114
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
264-423 1.58e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.77  E-value: 1.58e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41349476 264 CKADSCGKRLKSKDALKRHQENV-HTGDPKKKLIC--SVCNKKCSSASSLQEHRKIH------EIFDCQECMKKFISANQ 334
Cdd:COG5048 290 IKSKQCNISFSRSSPLTRHLRSVnHSGESLKPFSCpySLCGKLFSRNDALKRHILLHtsispaKEKLLNSSSKFSPLLNN 369

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41349476 335 LKR----HMITHSEKRPYNCE--ICNKSFKRLDQVGAHKVIHSEDKP--YKCKLCGKGFAHRNVYKNHKKTHSEERPFQC 406
Cdd:COG5048 370 EPPqslqQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLC 449

                       170
                ....*....|....*..
gi 41349476 407 EECKALFRTpFSLQRHL 423
Cdd:COG5048 450 SILKSFRRD-LDLSNHG 465
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
266-452 3.32e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 46.61  E-value: 3.32e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41349476 266 ADSCGKRLKSKDALKRHQENVH----TGDPKKKLICSVCNKKCSSASSLQEHR--KIHEI-----FDC--QECMKKFISA 332
Cdd:COG5048 257 ASESPRSSLPTASSQSSSPNESdsssEKGFSLPIKSKQCNISFSRSSPLTRHLrsVNHSGeslkpFSCpySLCGKLFSRN 336

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41349476 333 NQLKRHMITHSEKRPYNC--EICNKSFKRLD-----QVGAHKVIHSEDKPYKC--KLCGKGFAHRNVYKNHKKTHSEERP 403
Cdd:COG5048 337 DALKRHILLHTSISPAKEklLNSSSKFSPLLnneppQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRP 416

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|.
gi 41349476 404 FQCE--ECKALFRTPFSLQRHLLIHNSERTFKCHHCDATFKRKDTLNVHVQ 452
Cdd:COG5048 417 YNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGKD 467
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 513-568 7.84e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 45.48  E-value: 7.84e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 41349476 513 GERPYQCPY--CEKGFSKNDGLKMHiRTH--------------------TREKPYKCSECSKAFSQKRGLDEHkRTHT 568
Cdd:COG5189 346 DGKPYKCPVegCNKKYKNQNGLKYH-MLHghqnqklhenpspekmnifsAKDKPYRCEVCDKRYKNLNGLKYH-RKHS 421
PR-SET_PRDM8 cd19192
PR-SET domain found in PR domain zinc finger protein 8 (PRDM8) and similar proteins; PRDM8 ...
 22-125 1.06e-04

PR-SET domain found in PR domain zinc finger protein 8 (PRDM8) and similar proteins; PRDM8 (also termed PR domain-containing protein 8) may function as histone methyltransferase, preferentially acting on 'Lys-9' of histone H3.


Pssm-ID: 380969  Cd Length: 131  Bit Score: 42.42  E-value: 1.06e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41349476  22 GLYTARRVRKGEKFGPFAGEKRMPEDLDENMDYRLMWEVRGSKGEVLYILDATNPRHSNWLRFVHEAPSQEQKNLAAIQE 101
Cdd:cd19192  21 SVVTTTDIPAGTIFGPCVLSFTLGYDIADIALKTTDKRVVPYIFRVDTGACNGSSEPSDWLRLVQPARDRHEQNLEAFRK 100

                        90       100
                ....*....|....*....|....*
gi 41349476 102 GEN-IFYLAVEDIETDTELLIGYLD 125
Cdd:cd19192 101 NEGqVYFRTLRRIRKGEELLVWYSD 125
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
145-368 1.37e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 44.69  E-value: 1.37e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41349476 145 EVENSRRQSTAGRKDRLGCKEDYACPQCESSFTSEDILAEHLQTLHQKPTEEKEFKC--KNCGKKFPVKQALQRHVLQCT 222
Cdd:COG5048 268 ASSQSSSPNESDSSSEKGFSLPIKSKQCNISFSRSSPLTRHLRSVNHSGESLKPFSCpySLCGKLFSRNDALKRHILLHT 347

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41349476 223 AKSSlkessrsfqcsvcnssfssassfeqhqetcrgdarFVCKADSCGKRLKSKDALKRHQ--ENVHTGDPKKKLICSV- 299
Cdd:COG5048 348 SISP-----------------------------------AKEKLLNSSSKFSPLLNNEPPQslQQYKDLKNDKKSETLSn 392

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 41349476 300 -CNKKCSSASSLQEHRKIH-----EIFDCQECMKKFISANQLKRHMITHSEKRPYNCEICNKSFKRLDQVGAHKV 368
Cdd:COG5048 393 sCIRNFKRDSNLSLHIITHlsfrpYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGKD 467
SET_LegAS4-like cd10522
SET domain found in Legionella pneumophila type IV secretion system effector LegAS4 and ...
 9-123 1.38e-04

SET domain found in Legionella pneumophila type IV secretion system effector LegAS4 and similar proteins; LegAS4 is a type IV secretion system effector of Legionella pneumophila. It contains a SET domain that is involved in the modification of Lys4 of histone H3 (H3K4) in the nucleolus of the host cell, thereby enhancing heterochromatic rDNA transcription. It also contains an ankyrin repeat domain of unknown function at its C-terminal region.


Pssm-ID: 380920 [Multi-domain]  Cd Length: 122  Bit Score: 41.94  E-value: 1.38e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41349476   9 RFSLKSSRVQDGMGLYTARRVRKGEKFGPFAGEKRMPEDLDENMDYRLMWevrgskgevLYILDATNP-------RHSNW 81
Cdd:cd10522   3 DISMIPNLSHNGLGLFAAETIAKGEFVGEYTGEVLDRWEEDRDSVYHYDP---------LYPFDLNGDilvidagKKGNL 73

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 41349476  82 LRFVHEAPsqeQKNLAAIQ---EGEN-IFYLAVEDIETDTELLIGY 123
Cdd:cd10522  74 TRFINHSD---QPNLELIVrtlKGEQhIGFVAIRDIKPGEELFISY 116
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 459-540 1.61e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 44.32  E-value: 1.61e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41349476 459 KKYRCEL--CNKAFVTPSVLRSHKKTHtgekekicpYCGQKFASSGTLRVHIRSHTGERPYQCPYCEKGFSKNDGLKMHi 536
Cdd:COG5189 348 KPYKCPVegCNKKYKNQNGLKYHMLHG---------HQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKYH- 417


                ....
gi 41349476 537 RTHT 540
Cdd:COG5189 418 RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
532-556 2.38e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 2.38e-04
                          10        20
                  ....*....|....*....|....*
gi 41349476   532 LKMHIRTHTREKPYKCSECSKAFSQ 556
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
543-630 2.70e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.92  E-value: 2.70e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41349476 543 KPYKCSECSKAFSQKRGLDEHKRTHTGEKPFQCDV--CDLAFSLKKMLIRHKMTHNPNRPLAECQfchKKFTRNDYLKVH 620
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSK---SLPLSNSKASSS 108

                        90
                ....*....|
gi 41349476 621 MDNIHGVADS 630
Cdd:COG5048 109 SLSSSSSNSN 118
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
515-576 3.13e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.53  E-value: 3.13e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 41349476 515 RPYQCPYCEKGFSKNDGLKMHIRTHTREKPYKCSECSKAFSQKRG--LDEHKRTHTGEKPFQCD 576
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPleLSRHLRTHHNNPSDLNS 95
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 172-220 5.14e-04

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 39.08  E-value: 5.14e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*....
gi 41349476 172 CESSFTSEDILaehlqTLHQKpteEKEFKCKNCGKKFPVKQALQRHVLQ 220
Cdd:cd20908   7 CDREFDDEKIL-----IQHQK---AKHFKCHICHKKLYTAGGLAVHCLQ 47
zf-H2C2_2 pfam13465
Zinc-finger double domain;
504-528 6.60e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 6.60e-04
                          10        20
                  ....*....|....*....|....*
gi 41349476   504 LRVHIRSHTGERPYQCPYCEKGFSK 528
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 325-399 1.35e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.63  E-value: 1.35e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 41349476 325 CMKKFISANQLKRHMItHSEKRPYNCEICNKSfkrldqvgAHKVIHSEDKPYKCKLCGKGFAHRNVYKNHKKtHS 399
Cdd:COG5189 357 CNKKYKNQNGLKYHML-HGHQNQKLHENPSPE--------KMNIFSAKDKPYRCEVCDKRYKNLNGLKYHRK-HS 421
PHA00733 PHA00733
hypothetical protein
 490-536 1.49e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 39.09  E-value: 1.49e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 41349476  490 ICPYCGQKFASSGTLRVHIRshTGERPYQCPYCEKGFSKNDGLKMHI 536
Cdd:PHA00733  75 VCPLCLMPFSSSVSLKQHIR--YTEHSKVCPVCGKEFRNTDSTLDHV 119
zf-H2C2_2 pfam13465
Zinc-finger double domain;
560-583 1.60e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.60e-03
                          10        20
                  ....*....|....*....|....
gi 41349476   560 LDEHKRTHTGEKPFQCDVCDLAFS 583
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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