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Conserved domains on  [gi|8923881|ref|NP_061109|]
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WD repeat and SOCS box-containing protein 2 isoform 2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
30-360 9.97e-63

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 207.07  E-value: 9.97e-63
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923881   30 WSVAFSPDGSWFAWSQGHCIVKLipwpleeqfipkgFEAKSRSSKNETKGRGSPkektldcgqiVWGLAFSPwpsppsrk 109
Cdd:COG2319  82 LSVAFSPDGRLLASASADGTVRL-------------WDLATGLLLRTLTGHTGA----------VRSVAFSP-------- 130

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923881  110 lwarhhpqvpdvSCLVLATGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSLiLVSASRDKTLRIWDLNKhGKQ 189
Cdd:COG2319 131 ------------DGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKL-LASGSDDGTVRLWDLAT-GKL 196

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923881  190 IQVLSGHLQWVYCCSISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVSCDFSPDSALLVTASYDTNVIMWDPY 269
Cdd:COG2319 197 LRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLA 276

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923881  270 TGERLRSLHHtqvdpamddsdvHISSLRSVCFSPEGLYLATVADDRLLRIWALELKTPIA-FAPMTNGLCC-TFFPHGGV 347
Cdd:COG2319 277 TGELLRTLTG------------HSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRtLTGHTGAVRSvAFSPDGKT 344

                       330
                ....*....|...
gi 8923881  348 IATGTRDGHVQFW 360
Cdd:COG2319 345 LASGSDDGTVRLW 357
SOCS_WSB_SWIP cd03733
SOCS (suppressors of cytokine signaling) box of WSB/SWiP-like proteins. This subfamily ...
 364-402 2.98e-20

SOCS (suppressors of cytokine signaling) box of WSB/SWiP-like proteins. This subfamily contains WSB-1 (SOCS-box-containing WD-40 protein), part of an E3 ubiquitin ligase for the thyroid-hormone-activating type 2 iodothyronine deiodinase (D2), and SWiP-1 (SOCS box and WD-repeats in Protein), a WD40-containing protein that is expressed in embryonic structures of chickens and regulated by Sonic Hedgehog (Shh), as well as, their isoforms WSB-2 and SWiP-2. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


:

Pssm-ID: 239702  Cd Length: 39  Bit Score: 83.24  E-value: 2.98e-20
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 8923881  364 RVLSSLKHLCRKALRSFLTTYQVLALPIPKKMKEFLTYR 402
Cdd:cd03733   1 RVVSSLQHLCRMALRRVMTTQQVLALPIPKKMKEFLTYR 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
30-360 9.97e-63

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 207.07  E-value: 9.97e-63
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923881   30 WSVAFSPDGSWFAWSQGHCIVKLipwpleeqfipkgFEAKSRSSKNETKGRGSPkektldcgqiVWGLAFSPwpsppsrk 109
Cdd:COG2319  82 LSVAFSPDGRLLASASADGTVRL-------------WDLATGLLLRTLTGHTGA----------VRSVAFSP-------- 130

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923881  110 lwarhhpqvpdvSCLVLATGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSLiLVSASRDKTLRIWDLNKhGKQ 189
Cdd:COG2319 131 ------------DGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKL-LASGSDDGTVRLWDLAT-GKL 196

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923881  190 IQVLSGHLQWVYCCSISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVSCDFSPDSALLVTASYDTNVIMWDPY 269
Cdd:COG2319 197 LRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLA 276

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923881  270 TGERLRSLHHtqvdpamddsdvHISSLRSVCFSPEGLYLATVADDRLLRIWALELKTPIA-FAPMTNGLCC-TFFPHGGV 347
Cdd:COG2319 277 TGELLRTLTG------------HSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRtLTGHTGAVRSvAFSPDGKT 344

                       330
                ....*....|...
gi 8923881  348 IATGTRDGHVQFW 360
Cdd:COG2319 345 LASGSDDGTVRLW 357
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 121-360 1.87e-54

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 181.76  E-value: 1.87e-54
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923881  121 VSCL-------VLATGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSLiLVSASRDKTLRIWDLNKhGKQIQVL 193
Cdd:cd00200  12 VTCVafspdgkLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTY-LASGSSDKTIRLWDLET-GECVRTL 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923881  194 SGHLQWVYCCSISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVSCDFSPDSALLVTASYDTNVIMWDPYTGER 273
Cdd:cd00200  90 TGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKC 169

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923881  274 LRSLHHtqvdpamddsdvHISSLRSVCFSPEGLYLATVADDRLLRIWALELKTPIA-FAPMTNGL-CCTFFPHGGVIATG 351
Cdd:cd00200 170 VATLTG------------HTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGtLRGHENGVnSVAFSPDGYLLASG 237


                ....*....
gi 8923881  352 TRDGHVQFW 360
Cdd:cd00200 238 SEDGTIRVW 246
SOCS_WSB_SWIP cd03733
SOCS (suppressors of cytokine signaling) box of WSB/SWiP-like proteins. This subfamily ...
 364-402 2.98e-20

SOCS (suppressors of cytokine signaling) box of WSB/SWiP-like proteins. This subfamily contains WSB-1 (SOCS-box-containing WD-40 protein), part of an E3 ubiquitin ligase for the thyroid-hormone-activating type 2 iodothyronine deiodinase (D2), and SWiP-1 (SOCS box and WD-repeats in Protein), a WD40-containing protein that is expressed in embryonic structures of chickens and regulated by Sonic Hedgehog (Shh), as well as, their isoforms WSB-2 and SWiP-2. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239702  Cd Length: 39  Bit Score: 83.24  E-value: 2.98e-20
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 8923881  364 RVLSSLKHLCRKALRSFLTTYQVLALPIPKKMKEFLTYR 402
Cdd:cd03733   1 RVVSSLQHLCRMALRRVMTTQQVLALPIPKKMKEFLTYR 39
SOCS smart00253
suppressors of cytokine signalling; suppressors of cytokine signalling
 360-402 1.17e-12

suppressors of cytokine signalling; suppressors of cytokine signalling


Pssm-ID: 128549  Cd Length: 43  Bit Score: 61.93  E-value: 1.17e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 8923881     360 WTAPRVLSSLKHLCRKALRSFLTTYQVLALPIPKKMKEFLTYR 402
Cdd:smart00253   1 LPRPSNVPSLQHLCRFTIRRCTRTDQIKTLPLPPKLKDYLSYY 43
PTZ00421 PTZ00421
coronin; Provisional
 126-267 2.23e-09

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 59.14  E-value: 2.23e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923881   126 LATGLNDGQIKIWEVQT-GLL------LLNLSGHQDVVRDLSFTPSGSLILVSASRDKTLRIWDLNKhGKQIQVLSGHLQ 198
Cdd:PTZ00421  91 LFTASEDGTIMGWGIPEeGLTqnisdpIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVER-GKAVEVIKCHSD 169

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 8923881   199 WVYCCSISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVS-CDFSPDSALLVTASYDT----NVIMWD 267
Cdd:PTZ00421 170 QITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHASAKSQrCLWAKRKDLIITLGCSKsqqrQIMLWD 243
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 228-267 1.22e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 47.69  E-value: 1.22e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 8923881     228 SYTLIRKLEGHQSSVVSCDFSPDSALLVTASYDTNVIMWD 267
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
230-267 2.39e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.57  E-value: 2.39e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 8923881    230 TLIRKLEGHQSSVVSCDFSPDSALLVTASYDTNVIMWD 267
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
SOCS_box pfam07525
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more ...
 368-400 2.09e-05

SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.


Pssm-ID: 462192  Cd Length: 39  Bit Score: 41.38  E-value: 2.09e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 8923881    368 SLKHLCRKALRSFLTTY---QVLALPIPKKMKEFLT 400
Cdd:pfam07525   4 SLQHLCRLAIRRALGKRrlgAIDKLPLPPLLKDYLL 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
30-360 9.97e-63

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 207.07  E-value: 9.97e-63
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923881   30 WSVAFSPDGSWFAWSQGHCIVKLipwpleeqfipkgFEAKSRSSKNETKGRGSPkektldcgqiVWGLAFSPwpsppsrk 109
Cdd:COG2319  82 LSVAFSPDGRLLASASADGTVRL-------------WDLATGLLLRTLTGHTGA----------VRSVAFSP-------- 130

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923881  110 lwarhhpqvpdvSCLVLATGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSLiLVSASRDKTLRIWDLNKhGKQ 189
Cdd:COG2319 131 ------------DGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKL-LASGSDDGTVRLWDLAT-GKL 196

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923881  190 IQVLSGHLQWVYCCSISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVSCDFSPDSALLVTASYDTNVIMWDPY 269
Cdd:COG2319 197 LRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLA 276

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923881  270 TGERLRSLHHtqvdpamddsdvHISSLRSVCFSPEGLYLATVADDRLLRIWALELKTPIA-FAPMTNGLCC-TFFPHGGV 347
Cdd:COG2319 277 TGELLRTLTG------------HSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRtLTGHTGAVRSvAFSPDGKT 344

                       330
                ....*....|...
gi 8923881  348 IATGTRDGHVQFW 360
Cdd:COG2319 345 LASGSDDGTVRLW 357
WD40 COG2319
WD40 repeat [General function prediction only];
125-370 1.87e-57

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 193.20  E-value: 1.87e-57
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923881  125 VLATGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSlILVSASRDKTLRIWDLNKhGKQIQVLSGHLQWVYCCS 204
Cdd:COG2319  92 LLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGK-TLASGSADGTVRLWDLAT-GKLLRTLTGHSGAVTSVA 169

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923881  205 ISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVSCDFSPDSALLVTASYDTNVIMWDPYTGERLRSLHHtqvdp 284
Cdd:COG2319 170 FSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTG----- 244

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923881  285 amddsdvHISSLRSVCFSPEGLYLATVADDRLLRIWALELKTPIAFAPMTNG--LCCTFFPHGGVIATGTRDGHVQFWTA 362
Cdd:COG2319 245 -------HSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGgvNSVAFSPDGKLLASGSDDGTVRLWDL 317

                       250
                ....*....|
gi 8923881  363 --PRVLSSLK 370
Cdd:COG2319 318 atGKLLRTLT 327
WD40 COG2319
WD40 repeat [General function prediction only];
10-323 8.04e-55

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 186.27  E-value: 8.04e-55
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923881   10 LAELKPGRPHQFDWKSSCETWSVAFSPDGSWFAWSQGHCIVKLipWPLEEQFIPKGFEAKSRSsknetkgrgspkektld 89
Cdd:COG2319 104 LWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRL--WDLATGKLLRTLTGHSGA----------------- 164

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923881   90 cgqiVWGLAFSP----------------W--PSPPSRKLWARHHPQVPDVSCL----VLATGLNDGQIKIWEVQTGLLLL 147
Cdd:COG2319 165 ----VTSVAFSPdgkllasgsddgtvrlWdlATGKLLRTLTGHTGAVRSVAFSpdgkLLASGSADGTVRLWDLATGKLLR 240

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923881  148 NLSGHQDVVRDLSFTPSGSLiLVSASRDKTLRIWDLNKhGKQIQVLSGHLQWVYCCSISPDCSMLCSAAGEKSVFLWSMR 227
Cdd:COG2319 241 TLTGHSGSVRSVAFSPDGRL-LASGSADGTVRLWDLAT-GELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLA 318

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923881  228 SYTLIRKLEGHQSSVVSCDFSPDSALLVTASYDTNVIMWDPYTGERLRSLhhtqvdpamddsDVHISSLRSVCFSPEGLY 307
Cdd:COG2319 319 TGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTL------------TGHTGAVTSVAFSPDGRT 386

                       330
                ....*....|....*.
gi 8923881  308 LATVADDRLLRIWALE 323
Cdd:COG2319 387 LASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 121-360 1.87e-54

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 181.76  E-value: 1.87e-54
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923881  121 VSCL-------VLATGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSLiLVSASRDKTLRIWDLNKhGKQIQVL 193
Cdd:cd00200  12 VTCVafspdgkLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTY-LASGSSDKTIRLWDLET-GECVRTL 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923881  194 SGHLQWVYCCSISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVSCDFSPDSALLVTASYDTNVIMWDPYTGER 273
Cdd:cd00200  90 TGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKC 169

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923881  274 LRSLHHtqvdpamddsdvHISSLRSVCFSPEGLYLATVADDRLLRIWALELKTPIA-FAPMTNGL-CCTFFPHGGVIATG 351
Cdd:cd00200 170 VATLTG------------HTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGtLRGHENGVnSVAFSPDGYLLASG 237


                ....*....
gi 8923881  352 TRDGHVQFW 360
Cdd:cd00200 238 SEDGTIRVW 246
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 114-360 6.68e-52

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 175.22  E-value: 6.68e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923881  114 HHPQVPDVSCLV----LATGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSlILVSASRDKTLRIWDLNKhGKQ 189
Cdd:cd00200  50 HTGPVRDVAASAdgtyLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGR-ILSSSSRDKTIKVWDVET-GKC 127

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923881  190 IQVLSGHLQWVYCCSISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVSCDFSPDSALLVTASYDTNVIMWDPY 269
Cdd:cd00200 128 LTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLS 207

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923881  270 TGERLRSLHhtqvdpamddsdVHISSLRSVCFSPEGLYLATVADDRLLRIWALELKTPIAFAPMTNG--LCCTFFPHGGV 347
Cdd:cd00200 208 TGKCLGTLR------------GHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNsvTSLAWSPDGKR 275

                       250
                ....*....|...
gi 8923881  348 IATGTRDGHVQFW 360
Cdd:cd00200 276 LASGSADGTIRIW 288
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 120-321 4.60e-48

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 165.20  E-value: 4.60e-48
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923881  120 DVSCL-------VLATGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSLIlVSASRDKTLRIWDLNKhGKQIQV 192
Cdd:cd00200  95 YVSSVafspdgrILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFV-ASSSQDGTIKLWDLRT-GKCVAT 172

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923881  193 LSGHLQWVYCCSISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVSCDFSPDSALLVTASYDTNVIMWDPYTGE 272
Cdd:cd00200 173 LTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGE 252

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*....
gi 8923881  273 RLRSLHHtqvdpamddsdvHISSLRSVCFSPEGLYLATVADDRLLRIWA 321
Cdd:cd00200 253 CVQTLSG------------HTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
82-371 1.00e-45

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 162.39  E-value: 1.00e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923881   82 SPKEKTLDCGQIVWGLAFSPWPSPPSRKLWARHHPQVPDVSC----LVLATGLNDGQIKIWEVQTGLLLLNLSGHQDVVR 157
Cdd:COG2319   3 SADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAAspdgARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVL 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923881  158 DLSFTPSGSlILVSASRDKTLRIWDLNkHGKQIQVLSGHLQWVYCCSISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEG 237
Cdd:COG2319  83 SVAFSPDGR-LLASASADGTVRLWDLA-TGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTG 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923881  238 HQSSVVSCDFSPDSALLVTASYDTNVIMWDPYTGERLRSLhhtqvdpamddsDVHISSLRSVCFSPEGLYLATVADDRLL 317
Cdd:COG2319 161 HSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTL------------TGHTGAVRSVAFSPDGKLLASGSADGTV 228

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 8923881  318 RIWALELKTPIAFAPMTNG--LCCTFFPHGGVIATGTRDGHVQFW--TAPRVLSSLKH 371
Cdd:COG2319 229 RLWDLATGKLLRTLTGHSGsvRSVAFSPDGRLLASGSADGTVRLWdlATGELLRTLTG 286
WD40 COG2319
WD40 repeat [General function prediction only];
30-270 1.23e-43

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 156.61  E-value: 1.23e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923881   30 WSVAFSPDGSWFAWSQGHCIVKLipWPLEEQFIPKGFEAKSRSsknetkgrgspkektldcgqiVWGLAFSP-------- 101
Cdd:COG2319 166 TSVAFSPDGKLLASGSDDGTVRL--WDLATGKLLRTLTGHTGA---------------------VRSVAFSPdgkllasg 222

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923881  102 --------W--PSPPSRKLWARHHPQVPDVS----CLVLATGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSL 167
Cdd:COG2319 223 sadgtvrlWdlATGKLLRTLTGHSGSVRSVAfspdGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKL 302

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923881  168 iLVSASRDKTLRIWDLNKhGKQIQVLSGHLQWVYCCSISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVSCDF 247
Cdd:COG2319 303 -LASGSDDGTVRLWDLAT-GKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAF 380

                       250       260
                ....*....|....*....|...
gi 8923881  248 SPDSALLVTASYDTNVIMWDPYT 270
Cdd:COG2319 381 SPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 190-360 4.13e-28

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 112.04  E-value: 4.13e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923881  190 IQVLSGHLQWVYCCSISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVSCDFSPDSALLVTASYDTNVIMWDPY 269
Cdd:cd00200   2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLE 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923881  270 TGERLRSLHHtqvdpamddsdvHISSLRSVCFSPEGLYLATVADDRLLRIWALELKTPIAFAPMTNG--LCCTFFPHGGV 347
Cdd:cd00200  82 TGECVRTLTG------------HTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDwvNSVAFSPDGTF 149

                       170
                ....*....|...
gi 8923881  348 IATGTRDGHVQFW 360
Cdd:cd00200 150 VASSSQDGTIKLW 162
SOCS_WSB_SWIP cd03733
SOCS (suppressors of cytokine signaling) box of WSB/SWiP-like proteins. This subfamily ...
 364-402 2.98e-20

SOCS (suppressors of cytokine signaling) box of WSB/SWiP-like proteins. This subfamily contains WSB-1 (SOCS-box-containing WD-40 protein), part of an E3 ubiquitin ligase for the thyroid-hormone-activating type 2 iodothyronine deiodinase (D2), and SWiP-1 (SOCS box and WD-repeats in Protein), a WD40-containing protein that is expressed in embryonic structures of chickens and regulated by Sonic Hedgehog (Shh), as well as, their isoforms WSB-2 and SWiP-2. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239702  Cd Length: 39  Bit Score: 83.24  E-value: 2.98e-20
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 8923881  364 RVLSSLKHLCRKALRSFLTTYQVLALPIPKKMKEFLTYR 402
Cdd:cd03733   1 RVVSSLQHLCRMALRRVMTTQQVLALPIPKKMKEFLTYR 39
SOCS_WSB2_SWIP2 cd03745
SOCS (suppressors of cytokine signaling) box of WSB2/SWiP2-like proteins. This family consists ...
 364-402 3.74e-20

SOCS (suppressors of cytokine signaling) box of WSB2/SWiP2-like proteins. This family consists of WSB-2 (SOCS-box-containing WD-40 protein) and SWiP-2 (SOCS box and WD-repeats in Protein). No functional information is available for WSB2 or SWiP-2, but limited information is available for the isoforms WSB-1 and SWiP-1. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239714  Cd Length: 39  Bit Score: 82.64  E-value: 3.74e-20
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 8923881  364 RVLSSLKHLCRKALRSFLTTYQVLALPIPKKMKEFLTYR 402
Cdd:cd03745   1 RVLPSLRHLCRKALRHFLTTYQVLALPIPKKMKEFLTYR 39
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 231-360 1.26e-18

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 85.46  E-value: 1.26e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923881  231 LIRKLEGHQSSVVSCDFSPDSALLVTASYDTNVIMWDPYTGERLRSLHhtqvdpamddsdVHISSLRSVCFSPEGLYLAT 310
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLK------------GHTGPVRDVAASADGTYLAS 68

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 8923881  311 VADDRLLRIWALELKTPIA-FAPMTNG-LCCTFFPHGGVIATGTRDGHVQFW 360
Cdd:cd00200  69 GSSDKTIRLWDLETGECVRtLTGHTSYvSSVAFSPDGRILSSSSRDKTIKVW 120
SOCS smart00253
suppressors of cytokine signalling; suppressors of cytokine signalling
 360-402 1.17e-12

suppressors of cytokine signalling; suppressors of cytokine signalling


Pssm-ID: 128549  Cd Length: 43  Bit Score: 61.93  E-value: 1.17e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 8923881     360 WTAPRVLSSLKHLCRKALRSFLTTYQVLALPIPKKMKEFLTYR 402
Cdd:smart00253   1 LPRPSNVPSLQHLCRFTIRRCTRTDQIKTLPLPPKLKDYLSYY 43
SOCS_WSB1_SWIP1 cd03746
SOCS (suppressors of cytokine signaling) box of WSB1/SWiP1-like proteins. This subfamily ...
 364-403 4.28e-12

SOCS (suppressors of cytokine signaling) box of WSB1/SWiP1-like proteins. This subfamily contains WSB-1 (SOCS-box-containing WD-40 protein), part of an E3 ubiquitin ligase for the thyroid-hormone-activating type 2 iodothyronine deiodinase (D2) and SWiP-1 (SOCS box and WD-repeats in Protein), a WD40-containing protein that is expressed in embryonic structures of chickens and regulated by Sonic Hedgehog (Shh). The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239715  Cd Length: 40  Bit Score: 60.21  E-value: 4.28e-12
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 8923881  364 RVLSSLKHLCRKALRSFLTTYQVLALPIPKKMKEFLTYRT 403
Cdd:cd03746   1 RQVASLQHLCRMAIRRVMPTQQVKELPIPSKLLEFLTYRT 40
PTZ00421 PTZ00421
coronin; Provisional
 126-267 2.23e-09

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 59.14  E-value: 2.23e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923881   126 LATGLNDGQIKIWEVQT-GLL------LLNLSGHQDVVRDLSFTPSGSLILVSASRDKTLRIWDLNKhGKQIQVLSGHLQ 198
Cdd:PTZ00421  91 LFTASEDGTIMGWGIPEeGLTqnisdpIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVER-GKAVEVIKCHSD 169

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 8923881   199 WVYCCSISPDCSMLCSAAGEKSVFLWSMRSYTLIRKLEGHQSSVVS-CDFSPDSALLVTASYDT----NVIMWD 267
Cdd:PTZ00421 170 QITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHASAKSQrCLWAKRKDLIITLGCSKsqqrQIMLWD 243
SOCS cd03587
SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region ...
 368-402 8.51e-09

SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins with a SOCS box), and WSBs (WD40 repeat-containing proteins with a SOCS box), as well as, other miscellaneous proteins. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239641  Cd Length: 41  Bit Score: 50.93  E-value: 8.51e-09
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 8923881  368 SLKHLCRKALRSFL---TTYQVLALPIPKKMKEFLTYR 402
Cdd:cd03587   4 SLQHLCRLAIRRCLgkrRLDLIDKLPLPPRLKDYLLYK 41
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 228-267 1.22e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 47.69  E-value: 1.22e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 8923881     228 SYTLIRKLEGHQSSVVSCDFSPDSALLVTASYDTNVIMWD 267
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
230-267 2.39e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.57  E-value: 2.39e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 8923881    230 TLIRKLEGHQSSVVSCDFSPDSALLVTASYDTNVIMWD 267
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
SOCS_SOCS_like cd03717
SOCS (suppressors of cytokine signaling) box of SOCS-like proteins. The CIS/SOCS family of ...
 367-402 2.81e-07

SOCS (suppressors of cytokine signaling) box of SOCS-like proteins. The CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. These intracellular proteins regulate the responses of immune cells to cytokines. Identified as negative regulators of the cytokine-JAK-STAT pathway, they seem to play a role in many immunological and pathological processes. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. Related SOCS boxes are also present in Rab40-like proteins and insect proteins of unknown function that also contain a NEUZ (domain in neuralized proteins) domain.


Pssm-ID: 239687  Cd Length: 39  Bit Score: 46.44  E-value: 2.81e-07
                        10        20        30
                ....*....|....*....|....*....|....*.
gi 8923881  367 SSLKHLCRKALRSFLTTYQVLALPIPKKMKEFLTYR 402
Cdd:cd03717   4 RSLQHLCRFVIRQCTRRDLIDQLPLPRRLKDYLKEY 39
SOCS_box smart00969
The SOCS box acts as a bridge between specific substrate- binding domains and more generic ...
 367-402 3.50e-07

The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases;


Pssm-ID: 198037  Cd Length: 34  Bit Score: 46.25  E-value: 3.50e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 8923881     367 SSLKHLCRKALRSFLttYQVLALPIPKKMKEFLTYR 402
Cdd:smart00969   1 RSLQHLCRLAIRRSL--GGIDKLPLPPRLKDYLLYY 34
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 142-182 5.57e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.77  E-value: 5.57e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 8923881     142 TGLLLLNLSGHQDVVRDLSFTPSGSLiLVSASRDKTLRIWD 182
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKY-LASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 132-267 6.69e-07

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 51.63  E-value: 6.69e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923881   132 DGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSLILVSASRDKTLRIWDLNKhGKQIQVLSGHLQwvYCCSISPDCS- 210
Cdd:PLN00181 554 EGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLASGSDDGSVKLWSINQ-GVSIGTIKTKAN--ICCVQFPSESg 630

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 8923881   211 -MLCSAAGEKSVFLWSMRSYTL-IRKLEGHQSSVVSCDFSpDSALLVTASYDTNVIMWD 267
Cdd:PLN00181 631 rSLAFGSADHKVYYYDLRNPKLpLCTMIGHSKTVSYVRFV-DSSTLVSSSTDNTLKLWD 688
PTZ00420 PTZ00420
coronin; Provisional
 138-226 1.40e-06

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 50.33  E-value: 1.40e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923881   138 WEVQTGLLL--------------LNLSGHQDVVRDLSFTPSGSLILVSASRDKTLRIWDLNKHGKQIQ-------VLSGH 196
Cdd:PTZ00420  45 WEVEGGGLIgairlenqmrkppvIKLKGHTSSILDLQFNPCFSEILASGSEDLTIRVWEIPHNDESVKeikdpqcILKGH 124

                         90       100       110
                 ....*....|....*....|....*....|.
gi 8923881   197 LQWVYCCSISP-DCSMLCSAAGEKSVFLWSM 226
Cdd:PTZ00420 125 KKKISIIDWNPmNYYIMCSSGFDSFVNIWDI 155
WD40 pfam00400
WD domain, G-beta repeat;
143-182 1.80e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 44.26  E-value: 1.80e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 8923881    143 GLLLLNLSGHQDVVRDLSFTPSGSLiLVSASRDKTLRIWD 182
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKL-LASGSDDGTVKVWD 39
PTZ00421 PTZ00421
coronin; Provisional
 125-304 7.83e-06

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 47.97  E-value: 7.83e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923881   125 VLATGLNDGQIKIWEVQTGLLLLNLSGHQDVVRDLSFTPSGSLiLVSASRDKTLRIWDlNKHGKQIQVLSGHL-----QW 199
Cdd:PTZ00421 140 VLASAGADMVVNVWDVERGKAVEVIKCHSDQITSLEWNLDGSL-LCTTSKDKKLNIID-PRDGTIVSSVEAHAsaksqRC 217

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923881   200 VYCCSISPDCSMLCSAAGEKSVFLWSmrsytlIRKLEG-------HQSSVVSCD-FSPDSALLVTASYDTNVIMWDPYTG 271
Cdd:PTZ00421 218 LWAKRKDLIITLGCSKSQQRQIMLWD------TRKMASpystvdlDQSSALFIPfFDEDTNLLYIGSKGEGNIRCFELMN 291

                        170       180       190
                 ....*....|....*....|....*....|...
gi 8923881   272 ERLRSLHhtqvdpAMDDSDVHisslRSVCFSPE 304
Cdd:PTZ00421 292 ERLTFCS------SYSSVEPH----KGLCMMPK 314
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 187-225 9.30e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.30  E-value: 9.30e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 8923881     187 GKQIQVLSGHLQWVYCCSISPDCSMLCSAAGEKSVFLWS 225
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
SOCS_box pfam07525
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more ...
 368-400 2.09e-05

SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.


Pssm-ID: 462192  Cd Length: 39  Bit Score: 41.38  E-value: 2.09e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 8923881    368 SLKHLCRKALRSFLTTY---QVLALPIPKKMKEFLT 400
Cdd:pfam07525   4 SLQHLCRLAIRRALGKRrlgAIDKLPLPPLLKDYLL 39
WD40 pfam00400
WD domain, G-beta repeat;
187-225 3.35e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.79  E-value: 3.35e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 8923881    187 GKQIQVLSGHLQWVYCCSISPDCSMLCSAAGEKSVFLWS 225
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
SOCS_ASB_like cd03716
SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB ...
 368-402 7.51e-05

SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB (SPRY domain-containing SOCS box proteins) protein families. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence of a variable number of repeats. SSB proteins contain a central SPRY domain and a C-terminal SOCS. Recently, it has been shown that all four SSB proteins interact with the MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF), and that SSB-1, SSB-2, and SSB-4 interact with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain.


Pssm-ID: 239686  Cd Length: 42  Bit Score: 39.79  E-value: 7.51e-05
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 8923881  368 SLKHLCRKALRSFLTTY---QVLALPIPKKMKEFLTYR 402
Cdd:cd03716   5 SLQHLCRLAIRRCLGRRrleLIKKLPLPPRLKDYLLYE 42
PTZ00421 PTZ00421
coronin; Provisional
 149-268 3.78e-04

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 42.57  E-value: 3.78e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923881   149 LSGHQDVVRDLSFTPSGSLILVSASRDKTLRIWDLNKHGKQ------IQVLSGHLQWVYCCSISPDC-SMLCSAAGEKSV 221
Cdd:PTZ00421  71 LLGQEGPIIDVAFNPFDPQKLFTASEDGTIMGWGIPEEGLTqnisdpIVHLQGHTKKVGIVSFHPSAmNVLASAGADMVV 150

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 8923881   222 FLWSMRSYTLIRKLEGHQSSVVSCDFSPDSALLVTASYDTNVIMWDP 268
Cdd:PTZ00421 151 NVWDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDP 197
PTZ00420 PTZ00420
coronin; Provisional
 105-199 5.73e-04

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 41.86  E-value: 5.73e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923881   105 PPSRKLwARHHPQVPDVS---CL--VLATGLNDGQIKIWE----------VQTGLLLLNlsGHQDVVRDLSFTPSGSLIL 169
Cdd:PTZ00420  65 PPVIKL-KGHTSSILDLQfnpCFseILASGSEDLTIRVWEiphndesvkeIKDPQCILK--GHKKKISIIDWNPMNYYIM 141

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 8923881   170 VSASRDKTLRIWDLNKHGKQIQV-----LSGhLQW 199
Cdd:PTZ00420 142 CSSGFDSFVNIWDIENEKRAFQInmpkkLSS-LKW 175
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 292-320 8.47e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.91  E-value: 8.47e-04
                           10        20
                   ....*....|....*....|....*....
gi 8923881     292 HISSLRSVCFSPEGLYLATVADDRLLRIW 320
Cdd:smart00320  11 HTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
TolB COG0823
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, ...
 132-262 1.36e-03

Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440585 [Multi-domain]  Cd Length: 158  Bit Score: 39.27  E-value: 1.36e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 8923881  132 DGQIKIWEVQ-TGLLLLNLSGHQDVVRDLSFTPSGSLILVSASRDKTLRIWDLNKHGKQIQVLSGHLQWVYCCSISPDCS 210
Cdd:COG0823   8 DGNSDIYVVDlDGGEPRRLTNSPGIDTSPAWSPDGRRIAFTSDRGGGPQIYVVDADGGEPRRLTFGGGYNASPSWSPDGK 87

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 8923881  211 MLCSAAGEKSVF-LWSMRsytlirkLEGHQSSVVSCD-----FSPDSALLVTASYDTN 262
Cdd:COG0823  88 RLAFVSRSDGRFdIYVLD-------LDGGAPRRLTDGpgspsWSPDGRRIVFSSDRGG 138
SOCS_SOCS2 cd03736
SOCS (suppressors of cytokine signaling) box of SOCS2-like proteins. Together with CIS1, the ...
 368-404 3.57e-03

SOCS (suppressors of cytokine signaling) box of SOCS2-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS2 has recently been shown to regulate neuronal differentiation by controlling expression of a neurogenic transcription factor, Neurogenin-1. SOCS2 binds to GH receptors and inhibits the activation of STAT5b induced by GH. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239705  Cd Length: 41  Bit Score: 35.21  E-value: 3.57e-03
                        10        20        30
                ....*....|....*....|....*....|....*..
gi 8923881  368 SLKHLCRKALRSflTTYQVLALPIPKKMKEFLTYRTF 404
Cdd:cd03736   5 SLQHLCRITINK--CTRQIQELPLPTRLKDYLTEYTY 39
WD40 pfam00400
WD domain, G-beta repeat;
292-320 5.37e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 34.63  E-value: 5.37e-03
                          10        20
                  ....*....|....*....|....*....
gi 8923881    292 HISSLRSVCFSPEGLYLATVADDRLLRIW 320
Cdd:pfam00400  10 HTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
SOCS_SOCS6 cd03740
SOCS (suppressors of cytokine signaling) box of SOCS6-like proteins. Together with CIS1, the ...
 368-399 6.83e-03

SOCS (suppressors of cytokine signaling) box of SOCS6-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239709  Cd Length: 41  Bit Score: 34.32  E-value: 6.83e-03
                        10        20        30
                ....*....|....*....|....*....|..
gi 8923881  368 SLKHLCRKALRSFLTTYQVLALPIPKKMKEFL 399
Cdd:cd03740   5 SLQYLCRFVIRQYTRIDLIQKLPLPNKMKGYL 36
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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