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Conserved domains on  [gi|61743952|ref|NP_060831|]
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1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon [Homo sapiens]

Protein Classification

lysophospholipid acyltransferase family protein( domain architecture ID 10870651)

lysophospholipid acyltransferase (LPLAT) family protein may act as an acyltransferase of a de novo or remodeling pathway of glycerophospholipid biosynthesis, catalyzing the incorporation of an acyl group from either acyl-CoAs or acyl-acyl carrier proteins (acyl-ACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid

CATH:  1.10.1200.50
EC:  2.3.1.-
Gene Ontology:  GO:0016746|GO:0008654|GO:0006644
PubMed:  18287005|18931347|18718904|37611890
SCOP:  4003349

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LPLAT_LCLAT1-like cd07990
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; ...
 63-263 2.81e-73

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as Lysocardiolipin acyltransferase 1 (LCLAT1) or 1-acyl-sn-glycerol-3-phosphate acyltransferase and similar proteins.


:

Pssm-ID: 153252 [Multi-domain]  Cd Length: 193  Bit Score: 225.97  E-value: 2.81e-73
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61743952  63 LFFFENYTGVQILLYGDLPK-NKENIIYLANHQSTVDWIVADILAIRQNALGHVRYVLKEGLKWLPLYGCYFAQHGGIYV 141
Cdd:cd07990   1 VFLFEWLSGVKVVVYGDEPKlPKERALIISNHRSEVDWLVLWMLADRFGRLGRLKIVLKDSLKYPPLGGWGWQLGEFIFL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61743952 142 KRSAKFNEKEMRNKLQSYVDAGTPMYLVIFPEGTRYNPEQTKVlsaSQAFAAQRGLAVLKHVLTPRIKATHVAFDCMKNY 221
Cdd:cd07990  81 KRKWEKDEKTIKRQLKRLKDSPEPFWLLIFPEGTRFTEEKKER---SQEFAEKNGLPPLKHVLLPRTKGFVAILETLRDA 157

                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 61743952 222 LDAIYDVTVVYEGKDdggqrrESPTMTEFLCKECPKIHIHID 263
Cdd:cd07990 158 VDAVYDVTIAYPDGK------PPSEQRLLLGGKPREVHVHVR 193
Acyltransf_C pfam16076
Acyltransferase C-terminus; This domain is found at the C-terminus of several different ...
 258-312 7.47e-12

Acyltransferase C-terminus; This domain is found at the C-terminus of several different acyltransferases including 1-acyl-sn-glycerol-3-phosphate acyltransferase, acyl-CoA:lysophosphatidylglycerol acyltransferase 1 and lysocardiolipin acyltransferase 1.


:

Pssm-ID: 465006 [Multi-domain]  Cd Length: 74  Bit Score: 60.28  E-value: 7.47e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 61743952   258 IHIHIDRIDKKDVPEEQEHMRRWLHERFEIKDKMLIEFYE----SPDPERRKRFPGKSV 312
Cdd:pfam16076  10 VHMYIRRIPLEELPEDEEELAQWLHDLFVEKDKLLDYFYEtgtfFPGKEHIIPRRLKSL 68
 
Name Accession Description Interval E-value
LPLAT_LCLAT1-like cd07990
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; ...
 63-263 2.81e-73

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as Lysocardiolipin acyltransferase 1 (LCLAT1) or 1-acyl-sn-glycerol-3-phosphate acyltransferase and similar proteins.


Pssm-ID: 153252 [Multi-domain]  Cd Length: 193  Bit Score: 225.97  E-value: 2.81e-73
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61743952  63 LFFFENYTGVQILLYGDLPK-NKENIIYLANHQSTVDWIVADILAIRQNALGHVRYVLKEGLKWLPLYGCYFAQHGGIYV 141
Cdd:cd07990   1 VFLFEWLSGVKVVVYGDEPKlPKERALIISNHRSEVDWLVLWMLADRFGRLGRLKIVLKDSLKYPPLGGWGWQLGEFIFL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61743952 142 KRSAKFNEKEMRNKLQSYVDAGTPMYLVIFPEGTRYNPEQTKVlsaSQAFAAQRGLAVLKHVLTPRIKATHVAFDCMKNY 221
Cdd:cd07990  81 KRKWEKDEKTIKRQLKRLKDSPEPFWLLIFPEGTRFTEEKKER---SQEFAEKNGLPPLKHVLLPRTKGFVAILETLRDA 157

                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 61743952 222 LDAIYDVTVVYEGKDdggqrrESPTMTEFLCKECPKIHIHID 263
Cdd:cd07990 158 VDAVYDVTIAYPDGK------PPSEQRLLLGGKPREVHVHVR 193
PLN02510 PLN02510
probable 1-acyl-sn-glycerol-3-phosphate acyltransferase
 13-333 3.26e-52

probable 1-acyl-sn-glycerol-3-phosphate acyltransferase


Pssm-ID: 178126 [Multi-domain]  Cd Length: 374  Bit Score: 177.58  E-value: 3.26e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61743952   13 RYLLPSVVLLGTAPTYVLAWGvwrLLSAFLPaRFYQALDDR-----LYCVYQSMVLFFFENYTGVQILLYGDLPKNKENI 87
Cdd:PLN02510  19 RGLICLLVLLSTAFMMLVYLA---PVSAVLL-RLFSVHYSRkatsfFFGSWLALWPFLFEKINKTKVVFSGDKVPPEERV 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61743952   88 IYLANHQSTVDWIVADILAIRQNALGHVRYVLKEGLKWLPLYGCYFAQHGGIYVKRSAKFNEKEMRNKLQSYVDAGTPMY 167
Cdd:PLN02510  95 LLIANHRTEVDWMYLWDLALRKGCLGYIKYVLKSSLMKLPVFGWAFHIFEFIPVERKWEVDEPNIRQMLSSFKDPRDPLW 174

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61743952  168 LVIFPEGTRYNpEQTKVlsASQAFAAQRGLAVLKHVLTPRIKATHVAFDCMKNYLDAIYDVTVVYegkddggqRRESPTM 247
Cdd:PLN02510 175 LALFPEGTDYT-EAKCQ--RSQKFAAEHGLPILNNVLLPKTKGFVSCLQELRCSLDAVYDVTIGY--------KHRCPSF 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61743952  248 TEFLCKECP-KIHIHIDRIDKKDVPEEQEHMRRWLHERFEIKDKMLIEFYespdpeRRKRFPGKSVNSKLSIKKTLPSML 326
Cdd:PLN02510 244 LDNVFGIDPsEVHIHIRRIPLKQIPTSEDEVSAWLMDRFQLKDQLLSDFY------AQGHFPNEGTEGELSTLKCLANFL 317


                 ....*..
gi 61743952  327 ILSGLTA 333
Cdd:PLN02510 318 AVIALTT 324
PlsC smart00563
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either ...
 87-200 3.36e-20

Phosphate acyltransferases; Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities. Tafazzin, the product of the gene mutated in patients with Barth syndrome, is a member of this family.


Pssm-ID: 214724 [Multi-domain]  Cd Length: 118  Bit Score: 85.10  E-value: 3.36e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61743952     87 IIYLANHQSTVDWIVadILAIRQNALGHVRYVLKEGLKWLPLYGCYFAQHGGIYVKRSakfNEKEMRNKLQSYVDA-GTP 165
Cdd:smart00563   1 ALVVANHQSFLDPLV--LSALLPRKLGRVRFVAKKELFYVPLLGWLLRLLGAIFIDRS---NGRKARAALREAVELlKEG 75

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 61743952    166 MYLVIFPEGTRYNPEQTKVLSASQAFAAQRGLAVL 200
Cdd:smart00563  76 EWLLIFPEGTRSRPGKLLPFKKGAARLALEAGVPI 110
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
 36-176 2.30e-13

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 68.50  E-value: 2.30e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61743952  36 RLLSAFLPARFYQALddRLYCvyqSMVLFFFenYTGVQILLYGDLPKNKeNIIYLANHQSTVDWIVAdILAIRQnalgHV 115
Cdd:COG0204   2 RSLFLLLRRFRYRLV--RLWA---RLLLRLL--GVRVRVEGLENLPADG-PVLIVANHQSWLDILLL-LAALPR----PV 68

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 61743952 116 RYVLKEGLKWLPLYGCYFAQHGGIYVKRSAKFNEKEMRNKLQSYVDAGTPmyLVIFPEGTR 176
Cdd:COG0204  69 RFVAKKELFKIPLLGWLLRALGAIPVDRSKRRAALRALRQAVEALKAGES--LVIFPEGTR 127
Acyltransf_C pfam16076
Acyltransferase C-terminus; This domain is found at the C-terminus of several different ...
 258-312 7.47e-12

Acyltransferase C-terminus; This domain is found at the C-terminus of several different acyltransferases including 1-acyl-sn-glycerol-3-phosphate acyltransferase, acyl-CoA:lysophosphatidylglycerol acyltransferase 1 and lysocardiolipin acyltransferase 1.


Pssm-ID: 465006 [Multi-domain]  Cd Length: 74  Bit Score: 60.28  E-value: 7.47e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 61743952   258 IHIHIDRIDKKDVPEEQEHMRRWLHERFEIKDKMLIEFYE----SPDPERRKRFPGKSV 312
Cdd:pfam16076  10 VHMYIRRIPLEELPEDEEELAQWLHDLFVEKDKLLDYFYEtgtfFPGKEHIIPRRLKSL 68
Acyltransferase pfam01553
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis ...
 83-195 1.08e-10

Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.


Pssm-ID: 366704 [Multi-domain]  Cd Length: 131  Bit Score: 58.83  E-value: 1.08e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61743952    83 NKENIIYLANHQSTVDWIVADILAIRQNALghVRYVLKEGLKWLPLYGcYFAQHGG-IYVKRSAKFNEKEMRNKLQSYVD 161
Cdd:pfam01553  12 RGGPAIVVANHQSYLDVLLLSLALYKRGRP--LVFVAKKELFDIPLVG-WLMRLLGcIFIDRKNRKDAAGTLEYLVELLR 88

                          90       100       110
                  ....*....|....*....|....*....|....
gi 61743952   162 AGtpMYLVIFPEGTRYNPEQTKVLSASQAFAAQR 195
Cdd:pfam01553  89 EG--KLVVIFPEGTRSREGELLPFKKGAFRLAIE 120
AGP_acyltrn TIGR00530
1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous ...
 71-176 2.97e-09

1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous region of a collection of related proteins, several of which are known to act as 1-acyl-sn-glycerol-3-phosphate acyltransferases (EC 2.3.1.51). Proteins scoring above the trusted cutoff are likely to have the same general activity. However, there is variation among characterized members as to whether the acyl group can be donated by acyl carrier protein or coenzyme A, and in the length and saturation of the donated acyl group. 1-acyl-sn-glycerol-3-phosphate acyltransferase is also called 1-AGP acyltransferase, lysophosphatidic acid acyltransferase, and LPA acyltransferase. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 129621 [Multi-domain]  Cd Length: 130  Bit Score: 54.66  E-value: 2.97e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61743952    71 GVQILLYG--DLPKnKENIIYLANHQSTVDwIVADILAIRQNalghVRYVLKEGLKWLPLYGCYFAQHGGIYVKRSAKFN 148
Cdd:TIGR00530   1 GLKVEVVGpeNLPA-KSPVLVVANHQSNLD-PLTLSAAFPPP----IVFIAKKELKWIPFFGIMLWLTGAIFIDRENIRA 74

                          90       100
                  ....*....|....*....|....*...
gi 61743952   149 EKEMRNKLQSYVDAGTPmyLVIFPEGTR 176
Cdd:TIGR00530  75 IATALKAAIEVLKQGRS--IGVFPEGTR 100
 
Name Accession Description Interval E-value
LPLAT_LCLAT1-like cd07990
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; ...
 63-263 2.81e-73

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as Lysocardiolipin acyltransferase 1 (LCLAT1) or 1-acyl-sn-glycerol-3-phosphate acyltransferase and similar proteins.


Pssm-ID: 153252 [Multi-domain]  Cd Length: 193  Bit Score: 225.97  E-value: 2.81e-73
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61743952  63 LFFFENYTGVQILLYGDLPK-NKENIIYLANHQSTVDWIVADILAIRQNALGHVRYVLKEGLKWLPLYGCYFAQHGGIYV 141
Cdd:cd07990   1 VFLFEWLSGVKVVVYGDEPKlPKERALIISNHRSEVDWLVLWMLADRFGRLGRLKIVLKDSLKYPPLGGWGWQLGEFIFL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61743952 142 KRSAKFNEKEMRNKLQSYVDAGTPMYLVIFPEGTRYNPEQTKVlsaSQAFAAQRGLAVLKHVLTPRIKATHVAFDCMKNY 221
Cdd:cd07990  81 KRKWEKDEKTIKRQLKRLKDSPEPFWLLIFPEGTRFTEEKKER---SQEFAEKNGLPPLKHVLLPRTKGFVAILETLRDA 157

                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 61743952 222 LDAIYDVTVVYEGKDdggqrrESPTMTEFLCKECPKIHIHID 263
Cdd:cd07990 158 VDAVYDVTIAYPDGK------PPSEQRLLLGGKPREVHVHVR 193
PLN02510 PLN02510
probable 1-acyl-sn-glycerol-3-phosphate acyltransferase
 13-333 3.26e-52

probable 1-acyl-sn-glycerol-3-phosphate acyltransferase


Pssm-ID: 178126 [Multi-domain]  Cd Length: 374  Bit Score: 177.58  E-value: 3.26e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61743952   13 RYLLPSVVLLGTAPTYVLAWGvwrLLSAFLPaRFYQALDDR-----LYCVYQSMVLFFFENYTGVQILLYGDLPKNKENI 87
Cdd:PLN02510  19 RGLICLLVLLSTAFMMLVYLA---PVSAVLL-RLFSVHYSRkatsfFFGSWLALWPFLFEKINKTKVVFSGDKVPPEERV 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61743952   88 IYLANHQSTVDWIVADILAIRQNALGHVRYVLKEGLKWLPLYGCYFAQHGGIYVKRSAKFNEKEMRNKLQSYVDAGTPMY 167
Cdd:PLN02510  95 LLIANHRTEVDWMYLWDLALRKGCLGYIKYVLKSSLMKLPVFGWAFHIFEFIPVERKWEVDEPNIRQMLSSFKDPRDPLW 174

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61743952  168 LVIFPEGTRYNpEQTKVlsASQAFAAQRGLAVLKHVLTPRIKATHVAFDCMKNYLDAIYDVTVVYegkddggqRRESPTM 247
Cdd:PLN02510 175 LALFPEGTDYT-EAKCQ--RSQKFAAEHGLPILNNVLLPKTKGFVSCLQELRCSLDAVYDVTIGY--------KHRCPSF 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61743952  248 TEFLCKECP-KIHIHIDRIDKKDVPEEQEHMRRWLHERFEIKDKMLIEFYespdpeRRKRFPGKSVNSKLSIKKTLPSML 326
Cdd:PLN02510 244 LDNVFGIDPsEVHIHIRRIPLKQIPTSEDEVSAWLMDRFQLKDQLLSDFY------AQGHFPNEGTEGELSTLKCLANFL 317


                 ....*..
gi 61743952  327 ILSGLTA 333
Cdd:PLN02510 318 AVIALTT 324
PLN02380 PLN02380
1-acyl-sn-glycerol-3-phosphate acyltransferase
 63-295 5.26e-42

1-acyl-sn-glycerol-3-phosphate acyltransferase


Pssm-ID: 178006 [Multi-domain]  Cd Length: 376  Bit Score: 150.66  E-value: 5.26e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61743952   63 LFFFENYTGVQILLYGDLPK----NKENIIYLANHQSTVDWIVADILAIRQNALGHVRYVLKEGLKWLPLYG--CYFAQH 136
Cdd:PLN02380  58 IWLVDWWAGVKVQLYADEETfelmGKEHALVISNHRSDIDWLVGWILAQRSGCLGSALAVMKKSSKFLPVIGwsMWFSEY 137

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61743952  137 ggIYVKRSAKFNEKEMRNKLQSYVDAGTPMYLVIFPEGTRYNPEQtkvLSASQAFAAQRGLAVLKHVLTPRIKATHVAFD 216
Cdd:PLN02380 138 --VFLERSWAKDENTLKSGFQRLKDFPRPFWLALFVEGTRFTQAK---LLAAQEYAASRGLPVPRNVLIPRTKGFVSAVS 212

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 61743952  217 CMKNYLDAIYDVTVVYegkdDGGQRreSPTMTEFLCKECPKIHIHIDRIDKKDVPEEQEHMRRWLHERFEIKDKMLIEF 295
Cdd:PLN02380 213 NMRSFVPAIYDVTVAV----PKGQP--APTMLRIFRGQSSVVHVHIKRHSMKELPETDDGIAQWCKDVFVAKDALLDKH 285
PlsC smart00563
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either ...
 87-200 3.36e-20

Phosphate acyltransferases; Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities. Tafazzin, the product of the gene mutated in patients with Barth syndrome, is a member of this family.


Pssm-ID: 214724 [Multi-domain]  Cd Length: 118  Bit Score: 85.10  E-value: 3.36e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61743952     87 IIYLANHQSTVDWIVadILAIRQNALGHVRYVLKEGLKWLPLYGCYFAQHGGIYVKRSakfNEKEMRNKLQSYVDA-GTP 165
Cdd:smart00563   1 ALVVANHQSFLDPLV--LSALLPRKLGRVRFVAKKELFYVPLLGWLLRLLGAIFIDRS---NGRKARAALREAVELlKEG 75

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 61743952    166 MYLVIFPEGTRYNPEQTKVLSASQAFAAQRGLAVL 200
Cdd:smart00563  76 EWLLIFPEGTRSRPGKLLPFKKGAARLALEAGVPI 110
PRK14014 PRK14014
putative acyltransferase; Provisional
 89-298 7.50e-15

putative acyltransferase; Provisional


Pssm-ID: 237584 [Multi-domain]  Cd Length: 301  Bit Score: 74.12  E-value: 7.50e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61743952   89 YL--ANHQStvdWivADILAIRQNALGHV---RYVLKEGLKWLPLYG--CY-----FaqhggiyVKR-SAKFNEK--EMR 153
Cdd:PRK14014  89 YLviSNHQS---W--VDILVLQYVFNRRIpmlKFFLKQELIWVPFLGlaWWaldfpF-------MKRySKAYLAKnpELK 156

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61743952  154 NK-LQSYVDA-----GTPMYLVIFPEGTRYNPEqtKVLSASQAFaaqrglavlKHVLTPriKATHVAF--DCMKNYLDAI 225
Cdd:PRK14014 157 GKdLETTRRAcekfkRMPTTIVNFVEGTRFTPE--KHQQQQSPY---------QHLLKP--KAGGIAFalNAMGEQFDGL 223

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61743952  226 YDVTVVYEGKDdggqrresPTMTEFLCKECPKIHIHIDRIdkkDVPEE-----------QEHMRRWLHERFEIKDKMLIE 294
Cdd:PRK14014 224 LDVTIVYPDGR--------PSFWDLLSGRVKKIVVHVRLL---PIPEEligdyfndkefRRRFQQWLNQLWQEKDQLIEQ 292


                 ....
gi 61743952  295 FYES 298
Cdd:PRK14014 293 LLAQ 296
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
 36-176 2.30e-13

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 68.50  E-value: 2.30e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61743952  36 RLLSAFLPARFYQALddRLYCvyqSMVLFFFenYTGVQILLYGDLPKNKeNIIYLANHQSTVDWIVAdILAIRQnalgHV 115
Cdd:COG0204   2 RSLFLLLRRFRYRLV--RLWA---RLLLRLL--GVRVRVEGLENLPADG-PVLIVANHQSWLDILLL-LAALPR----PV 68

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 61743952 116 RYVLKEGLKWLPLYGCYFAQHGGIYVKRSAKFNEKEMRNKLQSYVDAGTPmyLVIFPEGTR 176
Cdd:COG0204  69 RFVAKKELFKIPLLGWLLRALGAIPVDRSKRRAALRALRQAVEALKAGES--LVIFPEGTR 127
LPLAT_AGPAT-like cd07989
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; ...
 82-181 4.58e-12

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.


Pssm-ID: 153251 [Multi-domain]  Cd Length: 184  Bit Score: 64.21  E-value: 4.58e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61743952  82 KNKENI------IYLANHQSTVDWIVadILAIrqnALGHVRYVLKEGLKWLPLYGCYFAQHGGIYVKRSAKFNEKEMRNK 155
Cdd:cd07989  15 EGLENLppkgpvIIVANHQSYLDPLV--LGAA---LPRPIRFVAKKELFKIPFLGWLLRLLGAIPIDRGNGRSAREALRE 89

                        90       100
                ....*....|....*....|....*.
gi 61743952 156 LQSYVDAGTPmyLVIFPEGTRYNPEQ 181
Cdd:cd07989  90 AIEALKEGES--VVIFPEGTRSRDGE 113
Acyltransf_C pfam16076
Acyltransferase C-terminus; This domain is found at the C-terminus of several different ...
 258-312 7.47e-12

Acyltransferase C-terminus; This domain is found at the C-terminus of several different acyltransferases including 1-acyl-sn-glycerol-3-phosphate acyltransferase, acyl-CoA:lysophosphatidylglycerol acyltransferase 1 and lysocardiolipin acyltransferase 1.


Pssm-ID: 465006 [Multi-domain]  Cd Length: 74  Bit Score: 60.28  E-value: 7.47e-12
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 61743952   258 IHIHIDRIDKKDVPEEQEHMRRWLHERFEIKDKMLIEFYE----SPDPERRKRFPGKSV 312
Cdd:pfam16076  10 VHMYIRRIPLEELPEDEEELAQWLHDLFVEKDKLLDYFYEtgtfFPGKEHIIPRRLKSL 68
Acyltransferase pfam01553
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis ...
 83-195 1.08e-10

Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.


Pssm-ID: 366704 [Multi-domain]  Cd Length: 131  Bit Score: 58.83  E-value: 1.08e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61743952    83 NKENIIYLANHQSTVDWIVADILAIRQNALghVRYVLKEGLKWLPLYGcYFAQHGG-IYVKRSAKFNEKEMRNKLQSYVD 161
Cdd:pfam01553  12 RGGPAIVVANHQSYLDVLLLSLALYKRGRP--LVFVAKKELFDIPLVG-WLMRLLGcIFIDRKNRKDAAGTLEYLVELLR 88

                          90       100       110
                  ....*....|....*....|....*....|....
gi 61743952   162 AGtpMYLVIFPEGTRYNPEQTKVLSASQAFAAQR 195
Cdd:pfam01553  89 EG--KLVVIFPEGTRSREGELLPFKKGAFRLAIE 120
AGP_acyltrn TIGR00530
1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous ...
 71-176 2.97e-09

1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous region of a collection of related proteins, several of which are known to act as 1-acyl-sn-glycerol-3-phosphate acyltransferases (EC 2.3.1.51). Proteins scoring above the trusted cutoff are likely to have the same general activity. However, there is variation among characterized members as to whether the acyl group can be donated by acyl carrier protein or coenzyme A, and in the length and saturation of the donated acyl group. 1-acyl-sn-glycerol-3-phosphate acyltransferase is also called 1-AGP acyltransferase, lysophosphatidic acid acyltransferase, and LPA acyltransferase. [Fatty acid and phospholipid metabolism, Biosynthesis]


Pssm-ID: 129621 [Multi-domain]  Cd Length: 130  Bit Score: 54.66  E-value: 2.97e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61743952    71 GVQILLYG--DLPKnKENIIYLANHQSTVDwIVADILAIRQNalghVRYVLKEGLKWLPLYGCYFAQHGGIYVKRSAKFN 148
Cdd:TIGR00530   1 GLKVEVVGpeNLPA-KSPVLVVANHQSNLD-PLTLSAAFPPP----IVFIAKKELKWIPFFGIMLWLTGAIFIDRENIRA 74

                          90       100
                  ....*....|....*....|....*...
gi 61743952   149 EKEMRNKLQSYVDAGTPmyLVIFPEGTR 176
Cdd:TIGR00530  75 IATALKAAIEVLKQGRS--IGVFPEGTR 100
LPLAT_LPCAT1-like cd07991
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like; ...
 78-175 1.68e-07

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as lysophosphatidylcholine acyltransferase 1 (LPCAT-1), glycerol-3-phosphate acyltransferase 3 (GPAT3), and similar sequences.


Pssm-ID: 153253 [Multi-domain]  Cd Length: 211  Bit Score: 51.07  E-value: 1.68e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61743952  78 GDLPKNKENIIYLANHQSTVDWIvadILAIrqnaLGHVRYVLKEGLKWLPLYGCYFAQHGGIYVKRSAKFNEKEMRNKLQ 157
Cdd:cd07991  17 GKPDPPEAPRIIVANHTSFIDPL---ILFS----DLFPSIVAKKELGKLPFIGTILRALGCIFVDRSEPKDRKKVVEEIK 89

                        90
                ....*....|....*...
gi 61743952 158 SYVDAGTPMYLVIFPEGT 175
Cdd:cd07991  90 ERATDPNWPPILIFPEGT 107
PLN02833 PLN02833
glycerol acyltransferase family protein
 14-182 5.88e-05

glycerol acyltransferase family protein


Pssm-ID: 215447  Cd Length: 376  Bit Score: 44.76  E-value: 5.88e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61743952   14 YLLPSVVLlGTAPTY---------VLAWGVWRLLSAFLPARFYQALDDRLY----CVYQSMVLFFFENYTGVqILLYGDL 80
Cdd:PLN02833  81 YLFPLWCV-GVVIRYgilfpvrvlLLAIGWIIFLSAFIPVHFLLKGHKLRKkierKLVELICSAFVASWTGV-IKYHGPR 158

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61743952   81 PKNKENIIYLANHQSTVDWIVADIL----AIRQNALGHVRYVLKEGLKWLplyGCyfaqhggIYVKRSaKFNEKEM-RNK 155
Cdd:PLN02833 159 PSRRPKQVFVANHTSMIDFIVLEQMtpfaVIMQKHPGWVGFLQNTILESV---GC-------IWFNRT-EAKDREVvAKK 227

                        170       180
                 ....*....|....*....|....*..
gi 61743952  156 LQSYVDAGTPMYLVIFPEGTRYNPEQT 182
Cdd:PLN02833 228 LRDHVQDPDRNPLLIFPEGTCVNNEYT 254
LPLAT_ABO13168-like cd07988
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ...
 78-176 8.24e-03

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are uncharacterized phospholipid/glycerol acyltransferases such as the Acinetobacter baumannii ATCC 17978 locus ABO13168 putative acyltransferase, and similar proteins.


Pssm-ID: 153250 [Multi-domain]  Cd Length: 163  Bit Score: 36.81  E-value: 8.24e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 61743952  78 GDLPKNKENIIYLANHQSTVDWIVAdILAIRQNALGhVRYVLKEGLKWLPLyGCYFAQHGGIYVKRSAKFNE-KEMRNKL 156
Cdd:cd07988  14 GEPPNKPKFVVIGAPHTSNWDFVLG-LLAAFALGLK-ISFLGKHSLFKPPL-GPFMRWLGGIPVDRSRAGGLvEQVVEEF 90

                        90       100
                ....*....|....*....|
gi 61743952 157 QSYvdagTPMYLVIFPEGTR 176
Cdd:cd07988  91 RRR----EEFVLAIAPEGTR 106
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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