NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|32171254|ref|NP_060743|]
View 

transmembrane protein 143 isoform a [Homo sapiens]

Protein Classification

TMEM143 family protein( domain architecture ID 38496)

TMEM143 family protein is a DUF3754 domain-containing protein; similar to Homo sapiens transmembrane protein 143 (TMEM143)

Gene Ontology:  GO:0016020

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
DUF3754 super family cl13951
Protein of unknown function (DUF3754); This domain family is found in bacteria, archaea and ...
 229-351 6.35e-09

Protein of unknown function (DUF3754); This domain family is found in bacteria, archaea and eukaryotes, and is typically between 135 and 166 amino acids in length. There is a single completely conserved residue P that may be functionally important.


The actual alignment was detected with superfamily member pfam12576:

Pssm-ID: 403691  Cd Length: 136  Bit Score: 54.19  E-value: 6.35e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32171254   229 PAERRYF-KRVVLAARTKRGHLVLKSFKDTPLEGLEQLLPELKVRTPTLQRALLNLMLVVSGVAIFVNVgmVVLTDLKVA 307
Cdd:pfam12576   9 FKSMAKFeKKKKKKPGIGPGPLYLKLFKNIPKADLEMIFPNKKVSMRLKDKLRLGVPAIGALGTVILKL--LKFEVWRNK 86

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 32171254   308 TSLLLLLFAIFMGL--RASKMFGQRRSAQA---LELAHMLYYRSTSNNS 351
Cdd:pfam12576  87 MSILIAVLSAVGALggFAFRQYTGYKNKKIryqKLVTKTLYFKTLASND 135
 
Name Accession Description Interval E-value
DUF3754 pfam12576
Protein of unknown function (DUF3754); This domain family is found in bacteria, archaea and ...
 229-351 6.35e-09

Protein of unknown function (DUF3754); This domain family is found in bacteria, archaea and eukaryotes, and is typically between 135 and 166 amino acids in length. There is a single completely conserved residue P that may be functionally important.


Pssm-ID: 403691  Cd Length: 136  Bit Score: 54.19  E-value: 6.35e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32171254   229 PAERRYF-KRVVLAARTKRGHLVLKSFKDTPLEGLEQLLPELKVRTPTLQRALLNLMLVVSGVAIFVNVgmVVLTDLKVA 307
Cdd:pfam12576   9 FKSMAKFeKKKKKKPGIGPGPLYLKLFKNIPKADLEMIFPNKKVSMRLKDKLRLGVPAIGALGTVILKL--LKFEVWRNK 86

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 32171254   308 TSLLLLLFAIFMGL--RASKMFGQRRSAQA---LELAHMLYYRSTSNNS 351
Cdd:pfam12576  87 MSILIAVLSAVGALggFAFRQYTGYKNKKIryqKLVTKTLYFKTLASND 135
 
Name Accession Description Interval E-value
DUF3754 pfam12576
Protein of unknown function (DUF3754); This domain family is found in bacteria, archaea and ...
 229-351 6.35e-09

Protein of unknown function (DUF3754); This domain family is found in bacteria, archaea and eukaryotes, and is typically between 135 and 166 amino acids in length. There is a single completely conserved residue P that may be functionally important.


Pssm-ID: 403691  Cd Length: 136  Bit Score: 54.19  E-value: 6.35e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 32171254   229 PAERRYF-KRVVLAARTKRGHLVLKSFKDTPLEGLEQLLPELKVRTPTLQRALLNLMLVVSGVAIFVNVgmVVLTDLKVA 307
Cdd:pfam12576   9 FKSMAKFeKKKKKKPGIGPGPLYLKLFKNIPKADLEMIFPNKKVSMRLKDKLRLGVPAIGALGTVILKL--LKFEVWRNK 86

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 32171254   308 TSLLLLLFAIFMGL--RASKMFGQRRSAQA---LELAHMLYYRSTSNNS 351
Cdd:pfam12576  87 MSILIAVLSAVGALggFAFRQYTGYKNKKIryqKLVTKTLYFKTLASND 135
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH