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Conserved domains on  [gi|31742492|ref|NP_060647|]
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NEDD4-binding protein 2 isoform 1 [Homo sapiens]

Protein Classification

NEDD4-binding protein 2( domain architecture ID 11603772)

NEDD4-binding protein 2 (N4BP2) has 5'-polynucleotide kinase and nicking endonuclease activity and may play a role in DNA repair or recombination

EC:  3.-.-.-
Gene Ontology:  GO:0004519|GO:0043130|GO:0005524

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF1771 pfam08590
Domain of unknown function (DUF1771); This domain is highly charged and may represent a small ...
 1621-1682 2.43e-19

Domain of unknown function (DUF1771); This domain is highly charged and may represent a small helical extension of the Smr domain (pfam01713), known as N-ext, whose function is not yet clear.


:

Pssm-ID: 462528  Cd Length: 62  Bit Score: 83.34  E-value: 2.43e-19
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 31742492   1621 DYRAEAFLHQQKRMECYSKAKEAYRIGKKNVATFYAQQGTLHEQKMKEANHLAAIEIFEKVN 1682
Cdd:pfam08590    1 RLRAEARKHARKRNELFQKAAEAYRRGDGAAAKELSEQGKEHGEKMEEANRQAAEAIFEENN 62
SMR smart00463
Small MutS-related domain;
1688-1770 2.25e-15

Small MutS-related domain;


:

Pssm-ID: 214676 [Multi-domain]  Cd Length: 80  Bit Score: 72.72  E-value: 2.25e-15
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31742492    1688 QNVLDLHGLHVDEALehlmRVLEKKTEEFKQNGGKPYLSVITGRGNHSQGGVARIKPAVIKYLISHSFRFSEIK-PGCLK 1766
Cdd:smart00463    1 KWSLDLHGLTVEEAL----TALDKFLNNARLKGLEQKLVIITGKGKHSLGGKSGVKPALKEHLRVESFRFAEEGnSGVLV 76


                    ....
gi 31742492    1767 VMLK 1770
Cdd:smart00463   77 VKLK 80
CUE_N4BP2 cd14365
CUE domain found in NEDD4-binding protein 2 (N4BP2) and similar proteins; N4BP2 has been ...
 47-87 2.36e-13

CUE domain found in NEDD4-binding protein 2 (N4BP2) and similar proteins; N4BP2 has been identified as an oncogene bcl-3 coding protein BCL-3-binding protein (B3BP) that participates in connecting transcriptional activation and genetic recombination of the Ig gene. In addition to BCL-3, it also interacts with p300/CBP histone acetyltransferases. N4BP2 shows intrinsic ATP binding and hydrolyzing activity. It contains an N-terminal ATP-binding region that is responsible for the interaction with BCL-3 and p300/CBP. N4BP2 also functions as a 5'-polynucleotide kinase that can transfer a phosphate group to the 5' end of DNA and RNA substrates. Moreover, N4BP2 contains a C-terminal MutS-related domain that possesses nicking endonuclease activity and may play a role in DNA mismatch repair (MMR). This model corresponds to CUE domain in the N-terminus of N4BP2.


:

Pssm-ID: 270548  Cd Length: 42  Bit Score: 65.77  E-value: 2.36e-13
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 31742492   47 QEELFTSISEIFSD-LDPDVVYLMLSECDFKVENAMDCLLEL 87
Cdd:cd14365    1 QEELFQQLQEMFSGkLDPSVVYMVLSECDFKVDNAMDTLLNL 42
AAA_33 super family cl38431
AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the ...
 449-580 4.44e-11

AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the AAA superfamily. Many of the proteins in this family are just short fragments so there is no Walker B motif.


The actual alignment was detected with superfamily member pfam13671:

Pssm-ID: 463952 [Multi-domain]  Cd Length: 143  Bit Score: 62.33  E-value: 4.44e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31742492    449 PGSGKSFLARTLQEDNPsGVILSTDDYF---YINGQ----YQFDVkyLGEAHEWNQNRAKEAFEKKIsPIIIDNTNLQAW 521
Cdd:pfam13671    8 PGSGKSTLARRLLEELG-AVRLSSDDERkrlFGEGRpsisYYTDA--TDRTYERLHELARIALRAGR-PVILDATNLRRD 83

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 31742492    522 EMKPYVALSQKHKYKVLFREPDTwwkfkPKELARRNIH------GVSKEKITRMLEHYQRFVSVP 580
Cdd:pfam13671   84 ERARLLALAREYGVPVRIVVFEA-----PEEVLRERLAararagGDPSDVPEEVLDRQKARFEPP 143
 
Name Accession Description Interval E-value
DUF1771 pfam08590
Domain of unknown function (DUF1771); This domain is highly charged and may represent a small ...
 1621-1682 2.43e-19

Domain of unknown function (DUF1771); This domain is highly charged and may represent a small helical extension of the Smr domain (pfam01713), known as N-ext, whose function is not yet clear.


Pssm-ID: 462528  Cd Length: 62  Bit Score: 83.34  E-value: 2.43e-19
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 31742492   1621 DYRAEAFLHQQKRMECYSKAKEAYRIGKKNVATFYAQQGTLHEQKMKEANHLAAIEIFEKVN 1682
Cdd:pfam08590    1 RLRAEARKHARKRNELFQKAAEAYRRGDGAAAKELSEQGKEHGEKMEEANRQAAEAIFEENN 62
SMR smart00463
Small MutS-related domain;
1688-1770 2.25e-15

Small MutS-related domain;


Pssm-ID: 214676 [Multi-domain]  Cd Length: 80  Bit Score: 72.72  E-value: 2.25e-15
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31742492    1688 QNVLDLHGLHVDEALehlmRVLEKKTEEFKQNGGKPYLSVITGRGNHSQGGVARIKPAVIKYLISHSFRFSEIK-PGCLK 1766
Cdd:smart00463    1 KWSLDLHGLTVEEAL----TALDKFLNNARLKGLEQKLVIITGKGKHSLGGKSGVKPALKEHLRVESFRFAEEGnSGVLV 76


                    ....
gi 31742492    1767 VMLK 1770
Cdd:smart00463   77 VKLK 80
CUE_N4BP2 cd14365
CUE domain found in NEDD4-binding protein 2 (N4BP2) and similar proteins; N4BP2 has been ...
 47-87 2.36e-13

CUE domain found in NEDD4-binding protein 2 (N4BP2) and similar proteins; N4BP2 has been identified as an oncogene bcl-3 coding protein BCL-3-binding protein (B3BP) that participates in connecting transcriptional activation and genetic recombination of the Ig gene. In addition to BCL-3, it also interacts with p300/CBP histone acetyltransferases. N4BP2 shows intrinsic ATP binding and hydrolyzing activity. It contains an N-terminal ATP-binding region that is responsible for the interaction with BCL-3 and p300/CBP. N4BP2 also functions as a 5'-polynucleotide kinase that can transfer a phosphate group to the 5' end of DNA and RNA substrates. Moreover, N4BP2 contains a C-terminal MutS-related domain that possesses nicking endonuclease activity and may play a role in DNA mismatch repair (MMR). This model corresponds to CUE domain in the N-terminus of N4BP2.


Pssm-ID: 270548  Cd Length: 42  Bit Score: 65.77  E-value: 2.36e-13
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 31742492   47 QEELFTSISEIFSD-LDPDVVYLMLSECDFKVENAMDCLLEL 87
Cdd:cd14365    1 QEELFQQLQEMFSGkLDPSVVYMVLSECDFKVDNAMDTLLNL 42
AAA_33 pfam13671
AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the ...
 449-580 4.44e-11

AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the AAA superfamily. Many of the proteins in this family are just short fragments so there is no Walker B motif.


Pssm-ID: 463952 [Multi-domain]  Cd Length: 143  Bit Score: 62.33  E-value: 4.44e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31742492    449 PGSGKSFLARTLQEDNPsGVILSTDDYF---YINGQ----YQFDVkyLGEAHEWNQNRAKEAFEKKIsPIIIDNTNLQAW 521
Cdd:pfam13671    8 PGSGKSTLARRLLEELG-AVRLSSDDERkrlFGEGRpsisYYTDA--TDRTYERLHELARIALRAGR-PVILDATNLRRD 83

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 31742492    522 EMKPYVALSQKHKYKVLFREPDTwwkfkPKELARRNIH------GVSKEKITRMLEHYQRFVSVP 580
Cdd:pfam13671   84 ERARLLALAREYGVPVRIVVFEA-----PEEVLRERLAararagGDPSDVPEEVLDRQKARFEPP 143
COG4639 COG4639
Predicted kinase [General function prediction only];
449-581 3.90e-09

Predicted kinase [General function prediction only];


Pssm-ID: 443677 [Multi-domain]  Cd Length: 145  Bit Score: 56.76  E-value: 3.90e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31742492  449 PGSGKSFLARTLQEDNPsgvILSTDDyfyINGQYQFDVKYLG-------EAHEwnqnRAKEAFEKKIsPIIIDNTNLQAW 521
Cdd:COG4639   11 PGSGKSTFARRLFAPTE---VVSSDD---IRALLGGDENDQSawgdvfqLAHE----IARARLRAGR-LTVVDATNLQRE 79

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 31742492  522 EMKPYVALSQKHKYKVlfrepdTWWKFKP--KELARRNI---HGVSKEKITRMlehYQRFVSVPI 581
Cdd:COG4639   80 ARRRLLALARAYGALV------VAVVLDVplEVCLARNAardRQVPEEVIRRM---LRRLRRPPL 135
Smr pfam01713
Smr domain; This family includes the Smr (Small MutS Related) proteins, and the C-terminal ...
 1692-1770 2.84e-08

Smr domain; This family includes the Smr (Small MutS Related) proteins, and the C-terminal region of the MutS2 protein. It has been suggested that this domain interacts with the MutS1 protein in the case of Smr proteins and with the N-terminal MutS related region of MutS2. This domain exhibits nicking endonuclease activity that might have a role in mismatch repair or genetic recombination. It shows no significant double strand cleavage or exonuclease activity. The full-length Swiss:Q86UW6 also has the polynucleotide kinase activity.


Pssm-ID: 460303 [Multi-domain]  Cd Length: 76  Bit Score: 52.47  E-value: 2.84e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31742492   1692 DLHGLHVDEALEHLMRVLEKKTEEfkqngGKPYLSVITGRGNHsqgGVarIKPAVIKYLISH----SFRFSEIKP---GC 1764
Cdd:pfam01713    1 DLHGMTVEEAREALDKFLDDALLA-----GLRCVLIIHGKGTH---GV--LRKAVREWLKQHplvlAFRSAPPGEggdGA 70


                   ....*.
gi 31742492   1765 LKVMLK 1770
Cdd:pfam01713   71 TYVLLK 76
SmrA COG2840
DNA-nicking endonuclease, Smr domain [Replication, recombination and repair];
1687-1754 1.55e-05

DNA-nicking endonuclease, Smr domain [Replication, recombination and repair];


Pssm-ID: 442088 [Multi-domain]  Cd Length: 177  Bit Score: 47.21  E-value: 1.55e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 31742492 1687 PQNVLDLHGLHVDEALEHLMRVLEKKTEEfkqngGKPYLSVITGRGNHSQGGVARIKPAVIKYLISHS 1754
Cdd:COG2840   88 PEARLDLHGLTVEEAREALAAFLAEAQRR-----GLRCVLIIHGKGLGSPGGRPVLKSQVPRWLRQHP 150
CUE pfam02845
CUE domain; CUE domains have been shown to bind ubiquitin. It has been suggested that CUE ...
 48-88 2.39e-03

CUE domain; CUE domains have been shown to bind ubiquitin. It has been suggested that CUE domains are related to pfam00627 and this has been confirmed by the structure of the domain. CUE domains also occur in two protein of the IL-1 signal transduction pathway, tollip and TAB2.


Pssm-ID: 427018  Cd Length: 42  Bit Score: 37.46  E-value: 2.39e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 31742492     48 EELFTSISEIFSDLDPDVVYLMLSECDFKVENAMDCLLELS 88
Cdd:pfam02845    2 EQMLETLKEMFPDLDEEVIRAVLEASNGNVEAAINALLEGS 42
 
Name Accession Description Interval E-value
DUF1771 pfam08590
Domain of unknown function (DUF1771); This domain is highly charged and may represent a small ...
 1621-1682 2.43e-19

Domain of unknown function (DUF1771); This domain is highly charged and may represent a small helical extension of the Smr domain (pfam01713), known as N-ext, whose function is not yet clear.


Pssm-ID: 462528  Cd Length: 62  Bit Score: 83.34  E-value: 2.43e-19
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 31742492   1621 DYRAEAFLHQQKRMECYSKAKEAYRIGKKNVATFYAQQGTLHEQKMKEANHLAAIEIFEKVN 1682
Cdd:pfam08590    1 RLRAEARKHARKRNELFQKAAEAYRRGDGAAAKELSEQGKEHGEKMEEANRQAAEAIFEENN 62
SMR smart00463
Small MutS-related domain;
1688-1770 2.25e-15

Small MutS-related domain;


Pssm-ID: 214676 [Multi-domain]  Cd Length: 80  Bit Score: 72.72  E-value: 2.25e-15
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31742492    1688 QNVLDLHGLHVDEALehlmRVLEKKTEEFKQNGGKPYLSVITGRGNHSQGGVARIKPAVIKYLISHSFRFSEIK-PGCLK 1766
Cdd:smart00463    1 KWSLDLHGLTVEEAL----TALDKFLNNARLKGLEQKLVIITGKGKHSLGGKSGVKPALKEHLRVESFRFAEEGnSGVLV 76


                    ....
gi 31742492    1767 VMLK 1770
Cdd:smart00463   77 VKLK 80
CUE_N4BP2 cd14365
CUE domain found in NEDD4-binding protein 2 (N4BP2) and similar proteins; N4BP2 has been ...
 47-87 2.36e-13

CUE domain found in NEDD4-binding protein 2 (N4BP2) and similar proteins; N4BP2 has been identified as an oncogene bcl-3 coding protein BCL-3-binding protein (B3BP) that participates in connecting transcriptional activation and genetic recombination of the Ig gene. In addition to BCL-3, it also interacts with p300/CBP histone acetyltransferases. N4BP2 shows intrinsic ATP binding and hydrolyzing activity. It contains an N-terminal ATP-binding region that is responsible for the interaction with BCL-3 and p300/CBP. N4BP2 also functions as a 5'-polynucleotide kinase that can transfer a phosphate group to the 5' end of DNA and RNA substrates. Moreover, N4BP2 contains a C-terminal MutS-related domain that possesses nicking endonuclease activity and may play a role in DNA mismatch repair (MMR). This model corresponds to CUE domain in the N-terminus of N4BP2.


Pssm-ID: 270548  Cd Length: 42  Bit Score: 65.77  E-value: 2.36e-13
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 31742492   47 QEELFTSISEIFSD-LDPDVVYLMLSECDFKVENAMDCLLEL 87
Cdd:cd14365    1 QEELFQQLQEMFSGkLDPSVVYMVLSECDFKVDNAMDTLLNL 42
AAA_33 pfam13671
AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the ...
 449-580 4.44e-11

AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the AAA superfamily. Many of the proteins in this family are just short fragments so there is no Walker B motif.


Pssm-ID: 463952 [Multi-domain]  Cd Length: 143  Bit Score: 62.33  E-value: 4.44e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31742492    449 PGSGKSFLARTLQEDNPsGVILSTDDYF---YINGQ----YQFDVkyLGEAHEWNQNRAKEAFEKKIsPIIIDNTNLQAW 521
Cdd:pfam13671    8 PGSGKSTLARRLLEELG-AVRLSSDDERkrlFGEGRpsisYYTDA--TDRTYERLHELARIALRAGR-PVILDATNLRRD 83

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 31742492    522 EMKPYVALSQKHKYKVLFREPDTwwkfkPKELARRNIH------GVSKEKITRMLEHYQRFVSVP 580
Cdd:pfam13671   84 ERARLLALAREYGVPVRIVVFEA-----PEEVLRERLAararagGDPSDVPEEVLDRQKARFEPP 143
COG4639 COG4639
Predicted kinase [General function prediction only];
449-581 3.90e-09

Predicted kinase [General function prediction only];


Pssm-ID: 443677 [Multi-domain]  Cd Length: 145  Bit Score: 56.76  E-value: 3.90e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31742492  449 PGSGKSFLARTLQEDNPsgvILSTDDyfyINGQYQFDVKYLG-------EAHEwnqnRAKEAFEKKIsPIIIDNTNLQAW 521
Cdd:COG4639   11 PGSGKSTFARRLFAPTE---VVSSDD---IRALLGGDENDQSawgdvfqLAHE----IARARLRAGR-LTVVDATNLQRE 79

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 31742492  522 EMKPYVALSQKHKYKVlfrepdTWWKFKP--KELARRNI---HGVSKEKITRMlehYQRFVSVPI 581
Cdd:COG4639   80 ARRRLLALARAYGALV------VAVVLDVplEVCLARNAardRQVPEEVIRRM---LRRLRRPPL 135
Smr pfam01713
Smr domain; This family includes the Smr (Small MutS Related) proteins, and the C-terminal ...
 1692-1770 2.84e-08

Smr domain; This family includes the Smr (Small MutS Related) proteins, and the C-terminal region of the MutS2 protein. It has been suggested that this domain interacts with the MutS1 protein in the case of Smr proteins and with the N-terminal MutS related region of MutS2. This domain exhibits nicking endonuclease activity that might have a role in mismatch repair or genetic recombination. It shows no significant double strand cleavage or exonuclease activity. The full-length Swiss:Q86UW6 also has the polynucleotide kinase activity.


Pssm-ID: 460303 [Multi-domain]  Cd Length: 76  Bit Score: 52.47  E-value: 2.84e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31742492   1692 DLHGLHVDEALEHLMRVLEKKTEEfkqngGKPYLSVITGRGNHsqgGVarIKPAVIKYLISH----SFRFSEIKP---GC 1764
Cdd:pfam01713    1 DLHGMTVEEAREALDKFLDDALLA-----GLRCVLIIHGKGTH---GV--LRKAVREWLKQHplvlAFRSAPPGEggdGA 70


                   ....*.
gi 31742492   1765 LKVMLK 1770
Cdd:pfam01713   71 TYVLLK 76
SmrA COG2840
DNA-nicking endonuclease, Smr domain [Replication, recombination and repair];
1687-1754 1.55e-05

DNA-nicking endonuclease, Smr domain [Replication, recombination and repair];


Pssm-ID: 442088 [Multi-domain]  Cd Length: 177  Bit Score: 47.21  E-value: 1.55e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 31742492 1687 PQNVLDLHGLHVDEALEHLMRVLEKKTEEfkqngGKPYLSVITGRGNHSQGGVARIKPAVIKYLISHS 1754
Cdd:COG2840   88 PEARLDLHGLTVEEAREALAAFLAEAQRR-----GLRCVLIIHGKGLGSPGGRPVLKSQVPRWLRQHP 150
CUE cd14279
CUE domain found in ubiquitin-binding CUE proteins; This family includes many coupling of ...
 48-85 2.79e-05

CUE domain found in ubiquitin-binding CUE proteins; This family includes many coupling of ubiquitin conjugation to endoplasmic reticulum degradation (CUE) domain containing proteins that are characterized by an FP and a di-leucine-like sequence and bind to monoubiquitin with varying affinities. Some higher eukaryotic CUE domain proteins do not bind monoubiquitin efficiently, since they carry LP, rather than FP among CUE domains. CUE domains form three-helix bundle structures and are distantly related to the ubiquitin-associated (UBA) domains which are widely occurring ubiquitin-binding motifs found in a broad range of cellular proteins in species ranging from yeast to human. The majority of family members contain one CUE domain, but some family members from fungi harbor two CUE domains.


Pssm-ID: 270465  Cd Length: 38  Bit Score: 42.84  E-value: 2.79e-05
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 31742492   48 EELFTSISEIFSDLDPDVVYLMLSECDFKVENAMDCLL 85
Cdd:cd14279    1 DEKLEQLQEMFPDLDEEVLEDVLEANNGDVEAAIDALL 38
CUE pfam02845
CUE domain; CUE domains have been shown to bind ubiquitin. It has been suggested that CUE ...
 48-88 2.39e-03

CUE domain; CUE domains have been shown to bind ubiquitin. It has been suggested that CUE domains are related to pfam00627 and this has been confirmed by the structure of the domain. CUE domains also occur in two protein of the IL-1 signal transduction pathway, tollip and TAB2.


Pssm-ID: 427018  Cd Length: 42  Bit Score: 37.46  E-value: 2.39e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 31742492     48 EELFTSISEIFSDLDPDVVYLMLSECDFKVENAMDCLLELS 88
Cdd:pfam02845    2 EQMLETLKEMFPDLDEEVIRAVLEASNGNVEAAINALLEGS 42
CUE_ASCC2 cd14364
CUE domain found in activating signal cointegrator 1 complex subunit 2 (ASCC2) and similar ...
 48-86 8.99e-03

CUE domain found in activating signal cointegrator 1 complex subunit 2 (ASCC2) and similar proteins; ASCC2, also called ASC-1 complex subunit p100 or Trip4 complex subunit p100, together with ASCC1 (also called p50) and ASCC3 (also called p300), form the activating signal cointegrator complex (ASCC). ASCC plays an essential role in activating protein 1 (AP-1), serum response factor (SRF), and nuclear factor kappaB (NF-kappaB) transactivation. It acts as a transcriptional coactivator of nuclear receptors and regulates the transrepression between nuclear receptors and either AP-1 or NF-kappaB in vivo. Members in this family all contain a CUE domain.


Pssm-ID: 270547  Cd Length: 40  Bit Score: 35.80  E-value: 8.99e-03
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 31742492   48 EELFTSISEIFSDLDPDVVYLMLSECDFKVENAMDCLLE 86
Cdd:cd14364    1 DSLISQVKDILPDLGEGFIEACLEHYNGNVERVINALLE 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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