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Conserved domains on  [gi|224589127|ref|NP_060596|]
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transmembrane protein 33 [Homo sapiens]

Protein Classification

TMEM33/Pom33 family protein( domain architecture ID 10508436)

TMEM33/Pom33 family protein similar to Homo sapiens transmembrane protein 33 (TMEM33) and Drosophila melanogaster Krueppel homolog 2

Gene Ontology:  GO:0061024|GO:0071786

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TMEM33_Pom33 pfam03661
Transmembrane protein 33/Nucleoporin POM33; This is an integral membrane protein family. ...
 9-245 1.93e-111

Transmembrane protein 33/Nucleoporin POM33; This is an integral membrane protein family. Family members include TMEM33/Pom33 proteins. Budding yeast Pom33 is a transmembrane nucleoporin that contributes to proper distribution and/or efficient assembly of nuclear pores. Proteins in this entry also include Tts1 from fission yeasts, Kr-h2 (krueppel homolog 2) from flies and TMEM33 from vertebrates. Tts1 is required for the correct positioning of the cellular division plane by delimiting the actomyosin ring assembly at the cell equator. Kr-h2 is a member of the dosage-dependent hierarchy effective upon white gene expression. TMEM33 regulates the tubular structure of endoplasmic reticulum by suppressing the membrane-shaping activity of reticulons.


:

Pssm-ID: 461009  Cd Length: 237  Bit Score: 320.00  E-value: 1.93e-111
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224589127    9 PQGAGAVQFMMTNKLDTAMWLSRLFTVYCSALFVLPLLGLHEAASFYQRALLANALTSALRLHQRLPHFQLSRAFLAQAL 88
Cdd:pfam03661   1 RGLESLLQHVIANKIELALWATRLLTIIFTILYIIPIFGSSHPYSAYYKALLANAATSALRLHQRLPQFQLSREFLQRLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224589127   89 LEDSCHYLLYSLIFVNSYPVTMSIFPVLLFSLLHAATYTKKVLDARGSNSLPLLRSVLDKLSANQQNILKFIACNEIFLM 168
Cdd:pfam03661  81 LEDSCHYLMYSLIFLFSAPVTLALLPVFLFALLHSASYTLTLLDVLGSNSWWGARLLISLVEFQSQNILRLIAFTEIFIM 160

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 224589127  169 PATVFMLFSGQGSLLQPFIYYRFLTLRYSSRRNPYCRTLFNELRIVVEHIIMKPACPLFVRRLCLQSIAFISRLAPT 245
Cdd:pfam03661 161 PLTIVLLFSGRASLLTPFIYYQFLSLRYSSRRNPYTRNAFSELRILLEHLANHPRCPAFIRSLILKLISFVSRLAPP 237
 
Name Accession Description Interval E-value
TMEM33_Pom33 pfam03661
Transmembrane protein 33/Nucleoporin POM33; This is an integral membrane protein family. ...
 9-245 1.93e-111

Transmembrane protein 33/Nucleoporin POM33; This is an integral membrane protein family. Family members include TMEM33/Pom33 proteins. Budding yeast Pom33 is a transmembrane nucleoporin that contributes to proper distribution and/or efficient assembly of nuclear pores. Proteins in this entry also include Tts1 from fission yeasts, Kr-h2 (krueppel homolog 2) from flies and TMEM33 from vertebrates. Tts1 is required for the correct positioning of the cellular division plane by delimiting the actomyosin ring assembly at the cell equator. Kr-h2 is a member of the dosage-dependent hierarchy effective upon white gene expression. TMEM33 regulates the tubular structure of endoplasmic reticulum by suppressing the membrane-shaping activity of reticulons.


Pssm-ID: 461009  Cd Length: 237  Bit Score: 320.00  E-value: 1.93e-111
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224589127    9 PQGAGAVQFMMTNKLDTAMWLSRLFTVYCSALFVLPLLGLHEAASFYQRALLANALTSALRLHQRLPHFQLSRAFLAQAL 88
Cdd:pfam03661   1 RGLESLLQHVIANKIELALWATRLLTIIFTILYIIPIFGSSHPYSAYYKALLANAATSALRLHQRLPQFQLSREFLQRLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224589127   89 LEDSCHYLLYSLIFVNSYPVTMSIFPVLLFSLLHAATYTKKVLDARGSNSLPLLRSVLDKLSANQQNILKFIACNEIFLM 168
Cdd:pfam03661  81 LEDSCHYLMYSLIFLFSAPVTLALLPVFLFALLHSASYTLTLLDVLGSNSWWGARLLISLVEFQSQNILRLIAFTEIFIM 160

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 224589127  169 PATVFMLFSGQGSLLQPFIYYRFLTLRYSSRRNPYCRTLFNELRIVVEHIIMKPACPLFVRRLCLQSIAFISRLAPT 245
Cdd:pfam03661 161 PLTIVLLFSGRASLLTPFIYYQFLSLRYSSRRNPYTRNAFSELRILLEHLANHPRCPAFIRSLILKLISFVSRLAPP 237
 
Name Accession Description Interval E-value
TMEM33_Pom33 pfam03661
Transmembrane protein 33/Nucleoporin POM33; This is an integral membrane protein family. ...
 9-245 1.93e-111

Transmembrane protein 33/Nucleoporin POM33; This is an integral membrane protein family. Family members include TMEM33/Pom33 proteins. Budding yeast Pom33 is a transmembrane nucleoporin that contributes to proper distribution and/or efficient assembly of nuclear pores. Proteins in this entry also include Tts1 from fission yeasts, Kr-h2 (krueppel homolog 2) from flies and TMEM33 from vertebrates. Tts1 is required for the correct positioning of the cellular division plane by delimiting the actomyosin ring assembly at the cell equator. Kr-h2 is a member of the dosage-dependent hierarchy effective upon white gene expression. TMEM33 regulates the tubular structure of endoplasmic reticulum by suppressing the membrane-shaping activity of reticulons.


Pssm-ID: 461009  Cd Length: 237  Bit Score: 320.00  E-value: 1.93e-111
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224589127    9 PQGAGAVQFMMTNKLDTAMWLSRLFTVYCSALFVLPLLGLHEAASFYQRALLANALTSALRLHQRLPHFQLSRAFLAQAL 88
Cdd:pfam03661   1 RGLESLLQHVIANKIELALWATRLLTIIFTILYIIPIFGSSHPYSAYYKALLANAATSALRLHQRLPQFQLSREFLQRLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224589127   89 LEDSCHYLLYSLIFVNSYPVTMSIFPVLLFSLLHAATYTKKVLDARGSNSLPLLRSVLDKLSANQQNILKFIACNEIFLM 168
Cdd:pfam03661  81 LEDSCHYLMYSLIFLFSAPVTLALLPVFLFALLHSASYTLTLLDVLGSNSWWGARLLISLVEFQSQNILRLIAFTEIFIM 160

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 224589127  169 PATVFMLFSGQGSLLQPFIYYRFLTLRYSSRRNPYCRTLFNELRIVVEHIIMKPACPLFVRRLCLQSIAFISRLAPT 245
Cdd:pfam03661 161 PLTIVLLFSGRASLLTPFIYYQFLSLRYSSRRNPYTRNAFSELRILLEHLANHPRCPAFIRSLILKLISFVSRLAPP 237
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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