NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|13324688|ref|NP_060587|]
View 

WD repeat-containing protein 11 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
487-820 1.13e-14

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 77.64  E-value: 1.13e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13324688  487 LLAVGTSNGSVLVYHLTSGLLHKELSIHSCEVKGIEWTSLTSFLsfATSTPNNmglvrnELQLVDLPTGRSIA-FRGERG 565
Cdd:COG2319   92 LLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTL--ASGSADG------TVRLWDLATGKLLRtLTGHSG 163

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13324688  566 ndesAIEMIKVSHLKQYLAVVFRDKPLELWDVRTCTLLREMSKNFPTITALEWSPSHnlkslrkKQLATreAMARQTV-- 643
Cdd:COG2319  164 ----AVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDG-------KLLAS--GSADGTVrl 230

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13324688  644 --VSDTELSIV----ESSVISLlqeaesksELSQNisaREHFVFTDIDGQVYHLTVEGNSVkdsaRIPPDGSMGSITCIA 717
Cdd:COG2319  231 wdLATGKLLRTltghSGSVRSV--------AFSPD---GRLLASGSADGTVRLWDLATGEL----LRTLTGHSGGVNSVA 295

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13324688  718 W--KGDTLVLGDMDGNLNFWDLK-GRVSRGIPTHRSWVRKIRFAPgkGNQKLIAMYNDG-AEVWDTKEVQMVSSLRSGRN 793
Cdd:COG2319  296 FspDGKLLASGSDDGTVRLWDLAtGKLLRTLTGHTGAVRSVAFSP--DGKTLASGSDDGtVRLWDLATGELLRTLTGHTG 373

                        330       340
                 ....*....|....*....|....*...
gi 13324688  794 vtfRILDVDWCTSDKVIL-ASDDGCIRV 820
Cdd:COG2319  374 ---AVTSVAFSPDGRTLAsGSADGTVRL 398
WD40 COG2319
WD40 repeat [General function prediction only];
8-168 1.11e-06

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 52.61  E-value: 1.11e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13324688    8 FKVSARTLTGALNAHNKA--AVDWGWQG--LIAYGCHSLVVVIDSITAQTLQVLEKHKADVVKVKWAREnyhhniGSpyc 83
Cdd:COG2319  105 WDLATGLLLRTLTGHTGAvrSVAFSPDGktLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPD------GK--- 175

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13324688   84 lRLASADVNGKIIVWDVAAGVAQCEIQEHAKPIQDVQWlwnqdaSRD--LLLAIHPPNYIVLWNADTGTKLWK-KSYADN 160
Cdd:COG2319  176 -LLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAF------SPDgkLLASGSADGTVRLWDLATGKLLRTlTGHSGS 248


                 ....*...
gi 13324688  161 ILSFSFDP 168
Cdd:COG2319  249 VRSVAFSP 256
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
487-820 1.13e-14

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 77.64  E-value: 1.13e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13324688  487 LLAVGTSNGSVLVYHLTSGLLHKELSIHSCEVKGIEWTSLTSFLsfATSTPNNmglvrnELQLVDLPTGRSIA-FRGERG 565
Cdd:COG2319   92 LLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTL--ASGSADG------TVRLWDLATGKLLRtLTGHSG 163

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13324688  566 ndesAIEMIKVSHLKQYLAVVFRDKPLELWDVRTCTLLREMSKNFPTITALEWSPSHnlkslrkKQLATreAMARQTV-- 643
Cdd:COG2319  164 ----AVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDG-------KLLAS--GSADGTVrl 230

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13324688  644 --VSDTELSIV----ESSVISLlqeaesksELSQNisaREHFVFTDIDGQVYHLTVEGNSVkdsaRIPPDGSMGSITCIA 717
Cdd:COG2319  231 wdLATGKLLRTltghSGSVRSV--------AFSPD---GRLLASGSADGTVRLWDLATGEL----LRTLTGHSGGVNSVA 295

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13324688  718 W--KGDTLVLGDMDGNLNFWDLK-GRVSRGIPTHRSWVRKIRFAPgkGNQKLIAMYNDG-AEVWDTKEVQMVSSLRSGRN 793
Cdd:COG2319  296 FspDGKLLASGSDDGTVRLWDLAtGKLLRTLTGHTGAVRSVAFSP--DGKTLASGSDDGtVRLWDLATGELLRTLTGHTG 373

                        330       340
                 ....*....|....*....|....*...
gi 13324688  794 vtfRILDVDWCTSDKVIL-ASDDGCIRV 820
Cdd:COG2319  374 ---AVTSVAFSPDGRTLAsGSADGTVRL 398
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 485-820 1.74e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 63.51  E-value: 1.74e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13324688  485 QPLLAVGTSNGSVLVYHLTSGLLHKELSIHSCEVKGIEWTSLTSFLsfATSTPNNMglvrneLQLVDLPTGRSIA-FRGe 563
Cdd:cd00200   21 GKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYL--ASGSSDKT------IRLWDLETGECVRtLTG- 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13324688  564 rgnDESAIEMIKVSHLKQYLAVVFRDKPLELWDVRTCTLLREMSKNFPTITALEWSPShnlkslrkKQLATreamarqTV 643
Cdd:cd00200   92 ---HTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPD--------GTFVA-------SS 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13324688  644 VSDTELSIVESSVISLLQeaeskselsqnisarehfVFTDIDGQVYHLTVEGNsvkdsarippdgsmgsitciawkGDTL 723
Cdd:cd00200  154 SQDGTIKLWDLRTGKCVA------------------TLTGHTGEVNSVAFSPD-----------------------GEKL 192

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13324688  724 VLGDMDGNLNFWDL-KGRVSRGIPTHRSWVRKIRFAPgkgNQKLIAMYN-DGA-EVWDTKEVQMVSSLRSGRNvtfRILD 800
Cdd:cd00200  193 LSSSSDGTIKLWDLsTGKCLGTLRGHENGVNSVAFSP---DGYLLASGSeDGTiRVWDLRTGECVQTLSGHTN---SVTS 266

                        330       340
                 ....*....|....*....|.
gi 13324688  801 VDWCTSDKVIL-ASDDGCIRV 820
Cdd:cd00200  267 LAWSPDGKRLAsGSADGTIRI 287
WD40 COG2319
WD40 repeat [General function prediction only];
8-168 1.11e-06

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 52.61  E-value: 1.11e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13324688    8 FKVSARTLTGALNAHNKA--AVDWGWQG--LIAYGCHSLVVVIDSITAQTLQVLEKHKADVVKVKWAREnyhhniGSpyc 83
Cdd:COG2319  105 WDLATGLLLRTLTGHTGAvrSVAFSPDGktLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPD------GK--- 175

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13324688   84 lRLASADVNGKIIVWDVAAGVAQCEIQEHAKPIQDVQWlwnqdaSRD--LLLAIHPPNYIVLWNADTGTKLWK-KSYADN 160
Cdd:COG2319  176 -LLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAF------SPDgkLLASGSADGTVRLWDLATGKLLRTlTGHSGS 248


                 ....*...
gi 13324688  161 ILSFSFDP 168
Cdd:COG2319  249 VRSVAFSP 256
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 54-179 2.76e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 50.41  E-value: 2.76e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13324688   54 LQVLEKHKADVVKVKWarenyhhnigSPYCLRLASADVNGKIIVWDVAAGVAQCEIQEHAKPIQDVQWLwnqdASRDLLL 133
Cdd:cd00200    2 RRTLKGHTGGVTCVAF----------SPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAAS----ADGTYLA 67

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 13324688  134 AIHPPNYIVLWNADTGTKLWK-KSYADNILSFSFDPfdpsHLTLLTS 179
Cdd:cd00200   68 SGSSDKTIRLWDLETGECVRTlTGHTSYVSSVAFSP----DGRILSS 110
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
487-820 1.13e-14

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 77.64  E-value: 1.13e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13324688  487 LLAVGTSNGSVLVYHLTSGLLHKELSIHSCEVKGIEWTSLTSFLsfATSTPNNmglvrnELQLVDLPTGRSIA-FRGERG 565
Cdd:COG2319   92 LLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTL--ASGSADG------TVRLWDLATGKLLRtLTGHSG 163

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13324688  566 ndesAIEMIKVSHLKQYLAVVFRDKPLELWDVRTCTLLREMSKNFPTITALEWSPSHnlkslrkKQLATreAMARQTV-- 643
Cdd:COG2319  164 ----AVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDG-------KLLAS--GSADGTVrl 230

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13324688  644 --VSDTELSIV----ESSVISLlqeaesksELSQNisaREHFVFTDIDGQVYHLTVEGNSVkdsaRIPPDGSMGSITCIA 717
Cdd:COG2319  231 wdLATGKLLRTltghSGSVRSV--------AFSPD---GRLLASGSADGTVRLWDLATGEL----LRTLTGHSGGVNSVA 295

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13324688  718 W--KGDTLVLGDMDGNLNFWDLK-GRVSRGIPTHRSWVRKIRFAPgkGNQKLIAMYNDG-AEVWDTKEVQMVSSLRSGRN 793
Cdd:COG2319  296 FspDGKLLASGSDDGTVRLWDLAtGKLLRTLTGHTGAVRSVAFSP--DGKTLASGSDDGtVRLWDLATGELLRTLTGHTG 373

                        330       340
                 ....*....|....*....|....*...
gi 13324688  794 vtfRILDVDWCTSDKVIL-ASDDGCIRV 820
Cdd:COG2319  374 ---AVTSVAFSPDGRTLAsGSADGTVRL 398
WD40 COG2319
WD40 repeat [General function prediction only];
487-780 9.17e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 65.32  E-value: 9.17e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13324688  487 LLAVGTSNGSVLVYHLTSGLLHKELSIHSCEVKGIEWTSLTSFLsfATSTPNNmglvrnELQLVDLPTGRSIA-FRGERG 565
Cdd:COG2319  134 TLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLL--ASGSDDG------TVRLWDLATGKLLRtLTGHTG 205

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13324688  566 ndesAIEMIKVSHLKQYLAVVFRDKPLELWDVRTCTLLREMSKNFPTITALEWSPSHNL-------KSLRKKQLATREAM 638
Cdd:COG2319  206 ----AVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLlasgsadGTVRLWDLATGELL 281

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13324688  639 ARQTVVSDTELSIVessvisllqeaeskselsqnISA-REHFVFTDIDGQVYHLTVEGNSVKDSaripPDGSMGSITCIA 717
Cdd:COG2319  282 RTLTGHSGGVNSVA--------------------FSPdGKLLASGSDDGTVRLWDLATGKLLRT----LTGHTGAVRSVA 337

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 13324688  718 W--KGDTLVLGDMDGNLNFWDLK-GRVSRGIPTHRSWVRKIRFAPgkGNQKLIAMYNDG-AEVWDTK 780
Cdd:COG2319  338 FspDGKTLASGSDDGTVRLWDLAtGELLRTLTGHTGAVTSVAFSP--DGRTLASGSADGtVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 485-820 1.74e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 63.51  E-value: 1.74e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13324688  485 QPLLAVGTSNGSVLVYHLTSGLLHKELSIHSCEVKGIEWTSLTSFLsfATSTPNNMglvrneLQLVDLPTGRSIA-FRGe 563
Cdd:cd00200   21 GKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYL--ASGSSDKT------IRLWDLETGECVRtLTG- 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13324688  564 rgnDESAIEMIKVSHLKQYLAVVFRDKPLELWDVRTCTLLREMSKNFPTITALEWSPShnlkslrkKQLATreamarqTV 643
Cdd:cd00200   92 ---HTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPD--------GTFVA-------SS 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13324688  644 VSDTELSIVESSVISLLQeaeskselsqnisarehfVFTDIDGQVYHLTVEGNsvkdsarippdgsmgsitciawkGDTL 723
Cdd:cd00200  154 SQDGTIKLWDLRTGKCVA------------------TLTGHTGEVNSVAFSPD-----------------------GEKL 192

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13324688  724 VLGDMDGNLNFWDL-KGRVSRGIPTHRSWVRKIRFAPgkgNQKLIAMYN-DGA-EVWDTKEVQMVSSLRSGRNvtfRILD 800
Cdd:cd00200  193 LSSSSDGTIKLWDLsTGKCLGTLRGHENGVNSVAFSP---DGYLLASGSeDGTiRVWDLRTGECVQTLSGHTN---SVTS 266

                        330       340
                 ....*....|....*....|.
gi 13324688  801 VDWCTSDKVIL-ASDDGCIRV 820
Cdd:cd00200  267 LAWSPDGKRLAsGSADGTIRI 287
WD40 COG2319
WD40 repeat [General function prediction only];
487-824 3.45e-08

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 57.23  E-value: 3.45e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13324688  487 LLAVGTSNGSVLVYHLTSGLLHKELSIHSCEVKGIEWTSLTSFLSFATSTpnnmglvrNELQLVDLPTGRSIAFRGERgn 566
Cdd:COG2319   50 RLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASAD--------GTVRLWDLATGLLLRTLTGH-- 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13324688  567 dESAIEMIKVSHLKQYLAVVFRDKPLELWDVRTCTLLREMSKNFPTITALEWSPShnlkslrKKQLATreamarqtvvsd 646
Cdd:COG2319  120 -TGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPD-------GKLLAS------------ 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13324688  647 telsivessvisllqeaeskselsqnisarehfvfTDIDGQVYHLTVEGNSVkdsaRIPPDGSMGSITCIAW--KGDTLV 724
Cdd:COG2319  180 -----------------------------------GSDDGTVRLWDLATGKL----LRTLTGHTGAVRSVAFspDGKLLA 220

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13324688  725 LGDMDGNLNFWDLK-GRVSRGIPTHRSWVRKIRFAPgkGNQKLIAMYNDG-AEVWDTKEVQMVSSLRSGRNvtfRILDVD 802
Cdd:COG2319  221 SGSADGTVRLWDLAtGKLLRTLTGHSGSVRSVAFSP--DGRLLASGSADGtVRLWDLATGELLRTLTGHSG---GVNSVA 295

                        330       340
                 ....*....|....*....|...
gi 13324688  803 WCTSDKVIL-ASDDGCIRVLEMS 824
Cdd:COG2319  296 FSPDGKLLAsGSDDGTVRLWDLA 318
WD40 COG2319
WD40 repeat [General function prediction only];
530-820 3.83e-07

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 53.76  E-value: 3.83e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13324688  530 LSFATSTPNNMGLVRNELQLVDLPTGRSIAFRGERGNDESAIEMIKVSHLKQYLAVVFRDKPLELWDVRTCTLLREMSKN 609
Cdd:COG2319   40 ASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGH 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13324688  610 FPTITALEWSPSHnlkslrkKQLATreAMARQTVVsdtelsivessvisllqeaeskselsqnisarehfVFTDIDGQVY 689
Cdd:COG2319  120 TGAVRSVAFSPDG-------KTLAS--GSADGTVR-----------------------------------LWDLATGKLL 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13324688  690 HlTVEGNSvkdsarippdgsmGSITCIAW--KGDTLVLGDMDGNLNFWDLK-GRVSRGIPTHRSWVRKIRFAPgkGNQKL 766
Cdd:COG2319  156 R-TLTGHS-------------GAVTSVAFspDGKLLASGSDDGTVRLWDLAtGKLLRTLTGHTGAVRSVAFSP--DGKLL 219

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 13324688  767 IAMYNDG-AEVWDTKEVQMVSSLRSGrnvTFRILDVDWCTSDKVIL-ASDDGCIRV 820
Cdd:COG2319  220 ASGSADGtVRLWDLATGKLLRTLTGH---SGSVRSVAFSPDGRLLAsGSADGTVRL 272
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 484-778 5.90e-07

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 52.72  E-value: 5.90e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13324688  484 YQPLLAVGTSNGSVLVYHLTSGLLHKELSIHSCEVKGIEWTSLTSFLSfaTSTPNNmglvrnELQLVDLPTGRSI-AFRG 562
Cdd:cd00200   62 DGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILS--SSSRDK------TIKVWDVETGKCLtTLRG 133

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13324688  563 ERGndesAIEMIKVSHLKQYLAVVFRDKPLELWDVRTCTLLREMSKNFPTITALEWSPShnlkslrKKQLAtreamarqT 642
Cdd:cd00200  134 HTD----WVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPD-------GEKLL--------S 194

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13324688  643 VVSDTELSIVESSVISLLQEAESKSElsqnisarehfvftdidgqvyhltvegnsvkdsarippdgsmgSITCIAW--KG 720
Cdd:cd00200  195 SSSDGTIKLWDLSTGKCLGTLRGHEN-------------------------------------------GVNSVAFspDG 231

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 13324688  721 DTLVLGDMDGNLNFWDL-KGRVSRGIPTHRSWVRKIRFAPgkGNQKLIAMYNDG-AEVWD 778
Cdd:cd00200  232 YLLASGSEDGTIRVWDLrTGECVQTLSGHTNSVTSLAWSP--DGKRLASGSADGtIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
8-168 1.11e-06

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 52.61  E-value: 1.11e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13324688    8 FKVSARTLTGALNAHNKA--AVDWGWQG--LIAYGCHSLVVVIDSITAQTLQVLEKHKADVVKVKWAREnyhhniGSpyc 83
Cdd:COG2319  105 WDLATGLLLRTLTGHTGAvrSVAFSPDGktLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPD------GK--- 175

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13324688   84 lRLASADVNGKIIVWDVAAGVAQCEIQEHAKPIQDVQWlwnqdaSRD--LLLAIHPPNYIVLWNADTGTKLWK-KSYADN 160
Cdd:COG2319  176 -LLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAF------SPDgkLLASGSADGTVRLWDLATGKLLRTlTGHSGS 248


                 ....*...
gi 13324688  161 ILSFSFDP 168
Cdd:COG2319  249 VRSVAFSP 256
WD40 COG2319
WD40 repeat [General function prediction only];
12-168 2.26e-06

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 51.45  E-value: 2.26e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13324688   12 ARTLTGALNAHNKAAVDWGWQGLIAYGCHSLVVVIDSITAQTLQVLEKHKADVVKVKWAREnyhhniGSpyclRLASADV 91
Cdd:COG2319   71 LATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPD------GK----TLASGSA 140

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13324688   92 NGKIIVWDVAAGVAQCEIQEHAKPIQDVQWlwnqdaSRD--LLLAIHPPNYIVLWNADTGTKLWK-KSYADNILSFSFDP 168
Cdd:COG2319  141 DGTVRLWDLATGKLLRTLTGHSGAVTSVAF------SPDgkLLASGSDDGTVRLWDLATGKLLRTlTGHTGAVRSVAFSP 214
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 54-179 2.76e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 50.41  E-value: 2.76e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13324688   54 LQVLEKHKADVVKVKWarenyhhnigSPYCLRLASADVNGKIIVWDVAAGVAQCEIQEHAKPIQDVQWLwnqdASRDLLL 133
Cdd:cd00200    2 RRTLKGHTGGVTCVAF----------SPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAAS----ADGTYLA 67

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 13324688  134 AIHPPNYIVLWNADTGTKLWK-KSYADNILSFSFDPfdpsHLTLLTS 179
Cdd:cd00200   68 SGSSDKTIRLWDLETGECVRTlTGHTSYVSSVAFSP----DGRILSS 110
WD40 COG2319
WD40 repeat [General function prediction only];
43-168 3.13e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 47.98  E-value: 3.13e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13324688   43 VVVIDSITAQTLQVLEKHKADVVKVKWarenyhhnigSPYCLRLASADVNGKIIVWDVAAGVAQCEIQEHAKPIQDVQWl 122
Cdd:COG2319  228 VRLWDLATGKLLRTLTGHSGSVRSVAF----------SPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAF- 296

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 13324688  123 wnqdaSRD--LLLAIHPPNYIVLWNADTGTKLWK-KSYADNILSFSFDP 168
Cdd:COG2319  297 -----SPDgkLLASGSDDGTVRLWDLATGKLLRTlTGHTGAVRSVAFSP 340
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 47-218 3.52e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 46.94  E-value: 3.52e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13324688   47 DSITAQTLQVLEKHKADVVKVKWarenyhhnigSPYCLRLASADVNGKIIVWDVAAGVAQCEIQEHAKPIQDVQWLWNQD 126
Cdd:cd00200   79 DLETGECVRTLTGHTSYVSSVAF----------SPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGT 148

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13324688  127 ----ASRDlllaihppNYIVLWNADTGTKLWK-KSYADNILSFSFDPfDPSHLTLLTSEGIVFISDFSPSKPP-SGPGKK 200
Cdd:cd00200  149 fvasSSQD--------GTIKLWDLRTGKCVATlTGHTGEVNSVAFSP-DGEKLLSSSSDGTIKLWDLSTGKCLgTLRGHE 219

                        170
                 ....*....|....*...
gi 13324688  201 VYISSPHSSPaHNKLATA 218
Cdd:cd00200  220 NGVNSVAFSP-DGYLLAS 236
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 50-121 2.84e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 44.25  E-value: 2.84e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 13324688   50 TAQTLQVLEKHKADVVKVKWARENYHhnigspyclrLASADVNGKIIVWDVAAGVAQCEIQEHAKPIQDVQW 121
Cdd:cd00200  208 TGKCLGTLRGHENGVNSVAFSPDGYL----------LASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAW 269
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 711-848 7.28e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 43.09  E-value: 7.28e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13324688  711 GSITCIAWKGDTLVL--GDMDGNLNFWDL-KGRVSRGIPTHRSWVRKIRFAPgkgNQKLIA--MYNDGAEVWDtkevqmv 785
Cdd:cd00200   94 SYVSSVAFSPDGRILssSSRDKTIKVWDVeTGKCLTTLRGHTDWVNSVAFSP---DGTFVAssSQDGTIKLWD------- 163

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 13324688  786 ssLRSGRNV-TFR-----ILDVDWC-TSDKVILASDDGCIRVLEMSMKS--ACFRMDEQELTEPVWCP--YLLV 848
Cdd:cd00200  164 --LRTGKCVaTLTghtgeVNSVAFSpDGEKLLSSSSDGTIKLWDLSTGKclGTLRGHENGVNSVAFSPdgYLLA 235
WD40 COG2319
WD40 repeat [General function prediction only];
43-168 8.76e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 43.36  E-value: 8.76e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13324688   43 VVVIDSITAQTLQVLEKHKADVVKVKWarenyhhnigSPYCLRLASADVNGKIIVWDVAAGVAQCEIQEHAKPIQDVQWl 122
Cdd:COG2319  270 VRLWDLATGELLRTLTGHSGGVNSVAF----------SPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAF- 338

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 13324688  123 wnqdaSRD--LLLAIHPPNYIVLWNADTGTKLWK-KSYADNILSFSFDP 168
Cdd:COG2319  339 -----SPDgkTLASGSDDGTVRLWDLATGELLRTlTGHTGAVTSVAFSP 382
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 10-99 4.26e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 40.78  E-value: 4.26e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13324688   10 VSARTLTGALNAHNKA--AVDWGWQGLIAYGCH--SLVVVIDSITAQTLQVLEKHKADVVKVKWarenyhhnigSPYCLR 85
Cdd:cd00200  206 LSTGKCLGTLRGHENGvnSVAFSPDGYLLASGSedGTIRVWDLRTGECVQTLSGHTNSVTSLAW----------SPDGKR 275

                         90
                 ....*....|....
gi 13324688   86 LASADVNGKIIVWD 99
Cdd:cd00200  276 LASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
43-148 5.32e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 40.66  E-value: 5.32e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13324688   43 VVVIDSITAQTLQVLEKHKADVVKVKWarenyhhnigSPYCLRLASADVNGKIIVWDVAAGVAQCEIQEHAKPIQDVQWl 122
Cdd:COG2319  312 VRLWDLATGKLLRTLTGHTGAVRSVAF----------SPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAF- 380

                         90       100
                 ....*....|....*....|....*...
gi 13324688  123 wnqdaSRD--LLLAIHPPNYIVLWNADT 148
Cdd:COG2319  381 -----SPDgrTLASGSADGTVRLWDLAT 403
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH