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Conserved domains on  [gi|157388939|ref|NP_060453|]
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WD repeat domain phosphoinositide-interacting protein 1 isoform a [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1000017)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 88-262 2.72e-12

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 66.97  E-value: 2.72e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157388939  88 FKKGTEICNYSY---SSNILSIRLNRQRLLVC---LEESIYIHNIKDMKLLKTLLDIPAnptGLCALSINHSNSYLAypG 161
Cdd:cd00200   78 WDLETGECVRTLtghTSYVSSVAFSPDGRILSsssRDKTIKVWDVETGKCLTTLRGHTD---WVNSVAFSPDGTFVA--S 152

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157388939 162 SLTSGEIVLYDGNSLKTVCTIAAHEGTLAAITFNASGSKLASASEKGTvIRVFSVPDGQKLYEFrRGMKRYVTisSLVFS 241
Cdd:cd00200  153 SSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGT-IKLWDLSTGKCLGTL-RGHENGVN--SVAFS 228

                        170       180
                 ....*....|....*....|.
gi 157388939 242 MDSQFLCASSNTETVHIFKLE 262
Cdd:cd00200  229 PDGYLLASGSEDGTIRVWDLR 249
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 88-262 2.72e-12

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 66.97  E-value: 2.72e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157388939  88 FKKGTEICNYSY---SSNILSIRLNRQRLLVC---LEESIYIHNIKDMKLLKTLLDIPAnptGLCALSINHSNSYLAypG 161
Cdd:cd00200   78 WDLETGECVRTLtghTSYVSSVAFSPDGRILSsssRDKTIKVWDVETGKCLTTLRGHTD---WVNSVAFSPDGTFVA--S 152

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157388939 162 SLTSGEIVLYDGNSLKTVCTIAAHEGTLAAITFNASGSKLASASEKGTvIRVFSVPDGQKLYEFrRGMKRYVTisSLVFS 241
Cdd:cd00200  153 SSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGT-IKLWDLSTGKCLGTL-RGHENGVN--SVAFS 228

                        170       180
                 ....*....|....*....|.
gi 157388939 242 MDSQFLCASSNTETVHIFKLE 262
Cdd:cd00200  229 PDGYLLASGSEDGTIRVWDLR 249
WD40 COG2319
WD40 repeat [General function prediction only];
120-262 5.31e-12

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 67.24  E-value: 5.31e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157388939 120 SIYIHNIKDMKLLKTLldiPANPTGLCALSINHSNSYLAYpGSlTSGEIVLYDGNSLKTVCTIAAHEGTLAAITFNASGS 199
Cdd:COG2319  185 TVRLWDLATGKLLRTL---TGHTGAVRSVAFSPDGKLLAS-GS-ADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGR 259

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 157388939 200 KLASASEKGTViRVFSVPDGQKLYEFRRGMKRyvtISSLVFSMDSQFLCASSNTETVHIFKLE 262
Cdd:COG2319  260 LLASGSADGTV-RLWDLATGELLRTLTGHSGG---VNSVAFSPDGKLLASGSDDGTVRLWDLA 318
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 88-262 2.72e-12

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 66.97  E-value: 2.72e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157388939  88 FKKGTEICNYSY---SSNILSIRLNRQRLLVC---LEESIYIHNIKDMKLLKTLLDIPAnptGLCALSINHSNSYLAypG 161
Cdd:cd00200   78 WDLETGECVRTLtghTSYVSSVAFSPDGRILSsssRDKTIKVWDVETGKCLTTLRGHTD---WVNSVAFSPDGTFVA--S 152

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157388939 162 SLTSGEIVLYDGNSLKTVCTIAAHEGTLAAITFNASGSKLASASEKGTvIRVFSVPDGQKLYEFrRGMKRYVTisSLVFS 241
Cdd:cd00200  153 SSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGT-IKLWDLSTGKCLGTL-RGHENGVN--SVAFS 228

                        170       180
                 ....*....|....*....|.
gi 157388939 242 MDSQFLCASSNTETVHIFKLE 262
Cdd:cd00200  229 PDGYLLASGSEDGTIRVWDLR 249
WD40 COG2319
WD40 repeat [General function prediction only];
120-262 5.31e-12

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 67.24  E-value: 5.31e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157388939 120 SIYIHNIKDMKLLKTLldiPANPTGLCALSINHSNSYLAYpGSlTSGEIVLYDGNSLKTVCTIAAHEGTLAAITFNASGS 199
Cdd:COG2319  185 TVRLWDLATGKLLRTL---TGHTGAVRSVAFSPDGKLLAS-GS-ADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGR 259

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 157388939 200 KLASASEKGTViRVFSVPDGQKLYEFRRGMKRyvtISSLVFSMDSQFLCASSNTETVHIFKLE 262
Cdd:COG2319  260 LLASGSADGTV-RLWDLATGELLRTLTGHSGG---VNSVAFSPDGKLLASGSDDGTVRLWDLA 318
WD40 COG2319
WD40 repeat [General function prediction only];
120-262 4.63e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 64.16  E-value: 4.63e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157388939 120 SIYIHNIKDMKLLKTLldiPANPTGLCALSINHSNSYLAYpGSlTSGEIVLYDGNSLKTVCTIAAHEGTLAAITFNASGS 199
Cdd:COG2319  269 TVRLWDLATGELLRTL---TGHSGGVNSVAFSPDGKLLAS-GS-DDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGK 343

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 157388939 200 KLASASEKGTViRVFSVPDGQKLYEFrRGMKRYVTisSLVFSMDSQFLCASSNTETVHIFKLE 262
Cdd:COG2319  344 TLASGSDDGTV-RLWDLATGELLRTL-TGHTGAVT--SVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
147-357 5.89e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 63.78  E-value: 5.89e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157388939 147 ALSINHSNSYLAYpGSlTSGEIVLYDGNSLKTVCTIAAHEGTLAAITFNASGSKLASASEKGTViRVFSVPDGQKLYEFR 226
Cdd:COG2319  125 SVAFSPDGKTLAS-GS-ADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTV-RLWDLATGKLLRTLT 201

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157388939 227 RGMKRyvtISSLVFSMDSQFLCASSNTETVHIFKLEqvtnsRPEEPSTWSGymgkmfmaatnylptqvsdmmHQDRAFAT 306
Cdd:COG2319  202 GHTGA---VRSVAFSPDGKLLASGSADGTVRLWDLA-----TGKLLRTLTG---------------------HSGSVRSV 252

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 157388939 307 ArlnFS--GQrnictlstiqklpRLLVASSSGHLYMYNLdpqDGGECVLIKTH 357
Cdd:COG2319  253 A---FSpdGR-------------LLASGSADGTVRLWDL---ATGELLRTLTG 286
WD40 COG2319
WD40 repeat [General function prediction only];
166-262 8.06e-08

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 54.15  E-value: 8.06e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157388939 166 GEIVLYDGNSLKTVCTIAAHEGTLAAITFNASGSKLASASEKGTViRVFSVPDGQKLYEFrRGMKRYVTisSLVFSMDSQ 245
Cdd:COG2319  100 GTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTV-RLWDLATGKLLRTL-TGHSGAVT--SVAFSPDGK 175

                         90
                 ....*....|....*..
gi 157388939 246 FLCASSNTETVHIFKLE 262
Cdd:COG2319  176 LLASGSDDGTVRLWDLA 192
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 144-352 1.74e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 49.26  E-value: 1.74e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157388939 144 GLCALSINHSNSYLAyPGSlTSGEIVLYDGNSLKTVCTIAAHEGTLAAITFNASGSKLASASEKGTvIRVFSVPDGQKLY 223
Cdd:cd00200   11 GVTCVAFSPDGKLLA-TGS-GDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKT-IRLWDLETGECVR 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157388939 224 EFRrGMKRYVtiSSLVFSMDSQFLCASSNTETVHIFKLEQVTNSRpeepsTWSGymgkmFMAATNYLPTQVSDMM----H 299
Cdd:cd00200   88 TLT-GHTSYV--SSVAFSPDGRILSSSSRDKTIKVWDVETGKCLT-----TLRG-----HTDWVNSVAFSPDGTFvassS 154

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 157388939 300 QDRafaTARL----------NFSG-QRNICTLSTIQKLPRLLVASSSGHLYMYNLdpqDGGECV 352
Cdd:cd00200  155 QDG---TIKLwdlrtgkcvaTLTGhTGEVNSVAFSPDGEKLLSSSSDGTIKLWDL---STGKCL 212
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 100-215 1.63e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 46.56  E-value: 1.63e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157388939 100 SSNILSIRL--NRQRLLVC-LEESIYIHNIKDMKLLKTLldiPANPTGLCALSINHSNSYLAypGSLTSGEIVLYDGNSL 176
Cdd:cd00200  177 TGEVNSVAFspDGEKLLSSsSDGTIKLWDLSTGKCLGTL---RGHENGVNSVAFSPDGYLLA--SGSEDGTIRVWDLRTG 251

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 157388939 177 KTVCTIAAHEGTLAAITFNASGSKLASASEKGTvIRVFS 215
Cdd:cd00200  252 ECVQTLSGHTNSVTSLAWSPDGKRLASGSADGT-IRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
120-218 2.68e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 46.06  E-value: 2.68e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157388939 120 SIYIHNIKDMKLLKTLldiPANPTGLCALSINHSNSYLAYPGSltSGEIVLYDGNSLKTVCTIAAHEGTLAAITFNASGS 199
Cdd:COG2319  311 TVRLWDLATGKLLRTL---TGHTGAVRSVAFSPDGKTLASGSD--DGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGR 385

                         90
                 ....*....|....*....
gi 157388939 200 KLASASEKGTvIRVFSVPD 218
Cdd:COG2319  386 TLASGSADGT-VRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 179-277 1.22e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 43.86  E-value: 1.22e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157388939 179 VCTIAAHEGTLAAITFNASGSKLASASEKGTvIRVFSVPDGQKLyefRRGMKRYVTISSLVFSMDSQFLCASSNTETVHI 258
Cdd:cd00200    2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGT-IKVWDLETGELL---RTLKGHTGPVRDVAASADGTYLASGSSDKTIRL 77

                         90
                 ....*....|....*....
gi 157388939 259 FKLEQvtnsrPEEPSTWSG 277
Cdd:cd00200   78 WDLET-----GECVRTLTG 91
WD40 COG2319
WD40 repeat [General function prediction only];
162-263 2.32e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 40.28  E-value: 2.32e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157388939 162 SLTSGEIVLYDGNSLKTVCTIAAHEGTLAAITFNASGSKLASASEKGTViRVFSVPDGQKLYEFrRGMKRYVTisSLVFS 241
Cdd:COG2319   54 GAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTV-RLWDLATGLLLRTL-TGHTGAVR--SVAFS 129

                         90       100
                 ....*....|....*....|..
gi 157388939 242 MDSQFLCASSNTETVHIFKLEQ 263
Cdd:COG2319  130 PDGKTLASGSADGTVRLWDLAT 151
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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