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Conserved domains on  [gi|408684407|ref|NP_060395|]
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DENN domain-containing protein 4C isoform 1 [Homo sapiens]

Protein Classification

DENN domain-containing protein( domain architecture ID 10655294)

DENN domain-containing protein may be involved in Rab-mediated processes or regulation of mitogen-activated protein kinase (MAPK) signalling pathways

CATH:  3.30.450.200|3.40.50.11500
Gene Ontology:  GO:0005085|GO:0032483
PubMed:  21330364|11563850
SCOP:  4007417|4006687

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DENN pfam02141
DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a ...
 309-492 3.27e-83

DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a domain which occurs in several proteins involved in Rab- mediated processes or regulation of MAPK signalling pathways.


:

Pssm-ID: 460461  Cd Length: 186  Bit Score: 270.98  E-value: 3.27e-83
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 408684407   309 TNKCICLLSHWPFFEAFRKFLMFIYKLSVSGPHPLPIEKHISHFMQNIPFPSPQRPRILVQLSVHDALILSQPVSTPLPL 388
Cdd:pfam02141    2 IPKAYCIISRLPFFNLFKKFLDELYRRRTISPLPNPIERFIANLLYEVPFPPPGRTQKLKPLGGTEPILLQRPEDSELPL 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 408684407   389 SGANFSTLLMNLGPENCATLLLFVLLESKILLHSLRPAVLTGVAEAVVAMIFPFQWQCPYIPLCPLSLAAVLSAPLPFIV 468
Cdd:pfam02141   82 EGVDLHLLFRCLSPENILQLFEAALLERRIIFLSSDLARLTLVAEAVVALLYPFVWQHIYIPVLPASLLDVLSAPTPFII 161

                          170       180
                   ....*....|....*....|....*
gi 408684407   469 GVDSRYFDL-HDPPQDVVCIDLDTN 492
Cdd:pfam02141  162 GVHSRYFDLlEDPLDDVVLVDLDTG 186
dDENN smart00801
Domain always found downstream of DENN domain, found in a variety of signalling proteins; The ...
 559-632 6.93e-21

Domain always found downstream of DENN domain, found in a variety of signalling proteins; The dDENN domain is part of the tripartite DENN domain. It is always found downstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


:

Pssm-ID: 129037  Cd Length: 69  Bit Score: 88.12  E-value: 6.93e-21
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 408684407    559 EMEIQEAFLRFMASILKGYRTYLRPITEAPSNKATaadslFDRQGFLKSRDRAYAKFYTLLSKTQIFIRFIEEC 632
Cdd:smart00801    1 NDEIREAFLRFFVNLFGGYRNFLRELRKEPGPVIT-----FDKESFLKSRPSSERPFLSKFLETQMFSQFIEER 69
uDENN smart00800
Domain always found upstream of DENN domain, found in a variety of signalling proteins; The ...
 192-276 7.28e-19

Domain always found upstream of DENN domain, found in a variety of signalling proteins; The uDENN domain is part of the tripartite DENN domain. It is always found upstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


:

Pssm-ID: 214824  Cd Length: 89  Bit Score: 83.15  E-value: 7.28e-19
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 408684407    192 FLCYKKSVPASNAIAYKAGLIFRYPEEDYESFPLSESdVPLFCLPMGATIECwdpETKYPLPVFSTFVLTGSSAKKVYGA 271
Cdd:smart00800    9 VVVGLDSDTGPLGRSYKPEILQRYPEKDFEDFPLPDS-IPLFCFPEGLDFVT---QTSSKDPQFFSFVLTDIDGSRRYGF 84


                    ....*
gi 408684407    272 AIQFY 276
Cdd:smart00800   85 CLRFY 89
 
Name Accession Description Interval E-value
DENN pfam02141
DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a ...
 309-492 3.27e-83

DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a domain which occurs in several proteins involved in Rab- mediated processes or regulation of MAPK signalling pathways.


Pssm-ID: 460461  Cd Length: 186  Bit Score: 270.98  E-value: 3.27e-83
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 408684407   309 TNKCICLLSHWPFFEAFRKFLMFIYKLSVSGPHPLPIEKHISHFMQNIPFPSPQRPRILVQLSVHDALILSQPVSTPLPL 388
Cdd:pfam02141    2 IPKAYCIISRLPFFNLFKKFLDELYRRRTISPLPNPIERFIANLLYEVPFPPPGRTQKLKPLGGTEPILLQRPEDSELPL 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 408684407   389 SGANFSTLLMNLGPENCATLLLFVLLESKILLHSLRPAVLTGVAEAVVAMIFPFQWQCPYIPLCPLSLAAVLSAPLPFIV 468
Cdd:pfam02141   82 EGVDLHLLFRCLSPENILQLFEAALLERRIIFLSSDLARLTLVAEAVVALLYPFVWQHIYIPVLPASLLDVLSAPTPFII 161

                          170       180
                   ....*....|....*....|....*
gi 408684407   469 GVDSRYFDL-HDPPQDVVCIDLDTN 492
Cdd:pfam02141  162 GVHSRYFDLlEDPLDDVVLVDLDTG 186
DENN smart00799
Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The ...
 309-492 1.37e-65

Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The DENN domain is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 214823  Cd Length: 183  Bit Score: 220.14  E-value: 1.37e-65
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 408684407    309 TNKCICLLSHWPFFEAFRKFLMFIYKLSVSGPhPLPIEKHISHFMQniPFPSPQRPRILVQLSVHDALILSQPVSTPLPL 388
Cdd:smart00799    1 APKCICILSRLPFFELFRKILNELYRLLPSSS-NLPLELLISLLLY--PVPPPGGSLVLVSLGPGDLIELQRPLDSSLPL 77

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 408684407    389 SGANFSTLLMNLGPENCATLLLFVLLESKILLHSLRPAVLTGVAEAVVAMIFPFQWQCPYIPLCPLSLAAVLSAPLPFIV 468
Cdd:smart00799   78 IDFSLHELFECLGVENILQLFAALLLERRIIFTSSNLSTLSAVIEALLALLYPFVWQHIYIPILPASLLDVLSAPTPFII 157

                           170       180
                    ....*....|....*....|....*.
gi 408684407    469 GVDSRYFDLHDPPQ--DVVCIDLDTN 492
Cdd:smart00799  158 GVHSSYFEEVKELPdeDVVVVDLDTG 183
dDENN smart00801
Domain always found downstream of DENN domain, found in a variety of signalling proteins; The ...
 559-632 6.93e-21

Domain always found downstream of DENN domain, found in a variety of signalling proteins; The dDENN domain is part of the tripartite DENN domain. It is always found downstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 129037  Cd Length: 69  Bit Score: 88.12  E-value: 6.93e-21
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 408684407    559 EMEIQEAFLRFMASILKGYRTYLRPITEAPSNKATaadslFDRQGFLKSRDRAYAKFYTLLSKTQIFIRFIEEC 632
Cdd:smart00801    1 NDEIREAFLRFFVNLFGGYRNFLRELRKEPGPVIT-----FDKESFLKSRPSSERPFLSKFLETQMFSQFIEER 69
uDENN smart00800
Domain always found upstream of DENN domain, found in a variety of signalling proteins; The ...
 192-276 7.28e-19

Domain always found upstream of DENN domain, found in a variety of signalling proteins; The uDENN domain is part of the tripartite DENN domain. It is always found upstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 214824  Cd Length: 89  Bit Score: 83.15  E-value: 7.28e-19
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 408684407    192 FLCYKKSVPASNAIAYKAGLIFRYPEEDYESFPLSESdVPLFCLPMGATIECwdpETKYPLPVFSTFVLTGSSAKKVYGA 271
Cdd:smart00800    9 VVVGLDSDTGPLGRSYKPEILQRYPEKDFEDFPLPDS-IPLFCFPEGLDFVT---QTSSKDPQFFSFVLTDIDGSRRYGF 84


                    ....*
gi 408684407    272 AIQFY 276
Cdd:smart00800   85 CLRFY 89
dDENN pfam03455
dDENN domain; This region is always found associated with pfam02141. It is predicted to form a ...
 599-648 1.56e-13

dDENN domain; This region is always found associated with pfam02141. It is predicted to form a globular domain. Although not statistically supported it has been suggested that this domain may be similar to members of the Rho/Rac/Cdc42 GEF family. This N-terminal region of DENN folds into a longin module, consisting of a central antiparallel beta-sheet layered between helix H1 and helices H2 and H3 (strands S1-S5). Rab35 interacts with dDENN via residues in helix 1 and in the loop S3-S4.


Pssm-ID: 460925  Cd Length: 48  Bit Score: 66.45  E-value: 1.56e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 408684407   599 FDRQGFLKSRDRAYAKFYTLLSKTQIFIRFIEECSFVSdkDTGLAFFDDC 648
Cdd:pfam03455    1 FDKEAFLKSLPSDSRPFLSQFLETQMFNEFIEERLESS--DPSIDLFDEE 48
uDENN pfam03456
uDENN domain; This region is always found associated with pfam02141. It is predicted to form ...
 211-273 2.80e-13

uDENN domain; This region is always found associated with pfam02141. It is predicted to form an all beta domain.


Pssm-ID: 460926  Cd Length: 59  Bit Score: 66.09  E-value: 2.80e-13
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 408684407   211 LIFRYPEEDYESFPLSESdVPLFCLPMGATiecwdpETKYPLPVFSTFVLTGSSAKKVYGAAI 273
Cdd:pfam03456    3 VLDRYPEDDWSDPPLPDG-IPMFCFPEGLE------TLSSREPTFFSFVLTDEDGSRLYGACL 58
 
Name Accession Description Interval E-value
DENN pfam02141
DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a ...
 309-492 3.27e-83

DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a domain which occurs in several proteins involved in Rab- mediated processes or regulation of MAPK signalling pathways.


Pssm-ID: 460461  Cd Length: 186  Bit Score: 270.98  E-value: 3.27e-83
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 408684407   309 TNKCICLLSHWPFFEAFRKFLMFIYKLSVSGPHPLPIEKHISHFMQNIPFPSPQRPRILVQLSVHDALILSQPVSTPLPL 388
Cdd:pfam02141    2 IPKAYCIISRLPFFNLFKKFLDELYRRRTISPLPNPIERFIANLLYEVPFPPPGRTQKLKPLGGTEPILLQRPEDSELPL 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 408684407   389 SGANFSTLLMNLGPENCATLLLFVLLESKILLHSLRPAVLTGVAEAVVAMIFPFQWQCPYIPLCPLSLAAVLSAPLPFIV 468
Cdd:pfam02141   82 EGVDLHLLFRCLSPENILQLFEAALLERRIIFLSSDLARLTLVAEAVVALLYPFVWQHIYIPVLPASLLDVLSAPTPFII 161

                          170       180
                   ....*....|....*....|....*
gi 408684407   469 GVDSRYFDL-HDPPQDVVCIDLDTN 492
Cdd:pfam02141  162 GVHSRYFDLlEDPLDDVVLVDLDTG 186
DENN smart00799
Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The ...
 309-492 1.37e-65

Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The DENN domain is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 214823  Cd Length: 183  Bit Score: 220.14  E-value: 1.37e-65
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 408684407    309 TNKCICLLSHWPFFEAFRKFLMFIYKLSVSGPhPLPIEKHISHFMQniPFPSPQRPRILVQLSVHDALILSQPVSTPLPL 388
Cdd:smart00799    1 APKCICILSRLPFFELFRKILNELYRLLPSSS-NLPLELLISLLLY--PVPPPGGSLVLVSLGPGDLIELQRPLDSSLPL 77

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 408684407    389 SGANFSTLLMNLGPENCATLLLFVLLESKILLHSLRPAVLTGVAEAVVAMIFPFQWQCPYIPLCPLSLAAVLSAPLPFIV 468
Cdd:smart00799   78 IDFSLHELFECLGVENILQLFAALLLERRIIFTSSNLSTLSAVIEALLALLYPFVWQHIYIPILPASLLDVLSAPTPFII 157

                           170       180
                    ....*....|....*....|....*.
gi 408684407    469 GVDSRYFDLHDPPQ--DVVCIDLDTN 492
Cdd:smart00799  158 GVHSSYFEEVKELPdeDVVVVDLDTG 183
dDENN smart00801
Domain always found downstream of DENN domain, found in a variety of signalling proteins; The ...
 559-632 6.93e-21

Domain always found downstream of DENN domain, found in a variety of signalling proteins; The dDENN domain is part of the tripartite DENN domain. It is always found downstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 129037  Cd Length: 69  Bit Score: 88.12  E-value: 6.93e-21
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 408684407    559 EMEIQEAFLRFMASILKGYRTYLRPITEAPSNKATaadslFDRQGFLKSRDRAYAKFYTLLSKTQIFIRFIEEC 632
Cdd:smart00801    1 NDEIREAFLRFFVNLFGGYRNFLRELRKEPGPVIT-----FDKESFLKSRPSSERPFLSKFLETQMFSQFIEER 69
uDENN smart00800
Domain always found upstream of DENN domain, found in a variety of signalling proteins; The ...
 192-276 7.28e-19

Domain always found upstream of DENN domain, found in a variety of signalling proteins; The uDENN domain is part of the tripartite DENN domain. It is always found upstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 214824  Cd Length: 89  Bit Score: 83.15  E-value: 7.28e-19
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 408684407    192 FLCYKKSVPASNAIAYKAGLIFRYPEEDYESFPLSESdVPLFCLPMGATIECwdpETKYPLPVFSTFVLTGSSAKKVYGA 271
Cdd:smart00800    9 VVVGLDSDTGPLGRSYKPEILQRYPEKDFEDFPLPDS-IPLFCFPEGLDFVT---QTSSKDPQFFSFVLTDIDGSRRYGF 84


                    ....*
gi 408684407    272 AIQFY 276
Cdd:smart00800   85 CLRFY 89
dDENN pfam03455
dDENN domain; This region is always found associated with pfam02141. It is predicted to form a ...
 599-648 1.56e-13

dDENN domain; This region is always found associated with pfam02141. It is predicted to form a globular domain. Although not statistically supported it has been suggested that this domain may be similar to members of the Rho/Rac/Cdc42 GEF family. This N-terminal region of DENN folds into a longin module, consisting of a central antiparallel beta-sheet layered between helix H1 and helices H2 and H3 (strands S1-S5). Rab35 interacts with dDENN via residues in helix 1 and in the loop S3-S4.


Pssm-ID: 460925  Cd Length: 48  Bit Score: 66.45  E-value: 1.56e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 408684407   599 FDRQGFLKSRDRAYAKFYTLLSKTQIFIRFIEECSFVSdkDTGLAFFDDC 648
Cdd:pfam03455    1 FDKEAFLKSLPSDSRPFLSQFLETQMFNEFIEERLESS--DPSIDLFDEE 48
uDENN pfam03456
uDENN domain; This region is always found associated with pfam02141. It is predicted to form ...
 211-273 2.80e-13

uDENN domain; This region is always found associated with pfam02141. It is predicted to form an all beta domain.


Pssm-ID: 460926  Cd Length: 59  Bit Score: 66.09  E-value: 2.80e-13
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 408684407   211 LIFRYPEEDYESFPLSESdVPLFCLPMGATiecwdpETKYPLPVFSTFVLTGSSAKKVYGAAI 273
Cdd:pfam03456    3 VLDRYPEDDWSDPPLPDG-IPMFCFPEGLE------TLSSREPTFFSFVLTDEDGSRLYGACL 58
SPA pfam08616
Stabilization of polarity axis; Swiss:Q99222 has been shown to interact with the outer plaque ...
 395-497 9.32e-03

Stabilization of polarity axis; Swiss:Q99222 has been shown to interact with the outer plaque of the spindle pole body. In Aspergillus nidulans the protein member is necessary for stabilization of the polarity axes during septation. and in S. cerevisiae it functions as a polarization-specific docking factor.


Pssm-ID: 400783  Cd Length: 113  Bit Score: 38.04  E-value: 9.32e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 408684407   395 TLLMNLGPEncaTLLLF--VLLESKILLHSlRPAVLTGVAEAVVA---MIFPFQ----WQCPYIPLCPLSLAAVLSAPLP 465
Cdd:pfam08616    6 KLLGPFTPP---IILLInaLLTSKRIIFLS-YQRSAGEVSEFVLAlcnLISGGFvlrgFTNNSFPYVDLSKLDALRKVPG 81

                           90       100       110
                   ....*....|....*....|....*....|..
gi 408684407   466 FIVGVDSRYFDLHDPPQDVVCiDLDTNMLYVS 497
Cdd:pfam08616   82 YIAGVTNPIFENQDQWWDVLC-DLDSGSVKLS 112
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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