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Conserved domains on  [gi|18379328|ref|NP_057712|]
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WW domain-containing adapter protein with coiled-coil isoform 1 [Homo sapiens]

Protein Classification

WW domain-containing protein( domain architecture ID 10449603)

WW domain-containing protein; the WW domain mediates protein-protein interaction via proline-rich motifs, such as PPxY

CATH:  2.20.70.10
Gene Ontology:  GO:0005515
PubMed:  22201747|9029943|7641887

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WW pfam00397
WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds ...
 133-160 4.11e-09

WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds proline-rich peptide motifs in vitro.


:

Pssm-ID: 459800 [Multi-domain]  Cd Length: 30  Bit Score: 52.12  E-value: 4.11e-09
                          10        20
                  ....*....|....*....|....*...
gi 18379328   133 DDWSEHISSSGKKYYYNCRTEVSQWEKP 160
Cdd:pfam00397   3 PGWEERWDPDGRVYYYNHETGETQWEKP 30
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 235-511 4.68e-06

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 50.32  E-value: 4.68e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18379328   235 PRAETHSSSTPVQHPIKPvvhPTATPSTVPSSPFTLQSDHQPKKSFDANGASTLSKLPTPTSSVPAQKTERKESTSGDKP 314
Cdd:PHA03247 2609 RGPAPPSPLPPDTHAPDP---PPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRR 2685

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18379328   315 VSHSCTTPSTSSASglNPTSAPPTSASAvPVSPVPQSPIPPLLQDPNLLRQLLPALQATLQLNNSNVDISKINEVLTAAV 394
Cdd:PHA03247 2686 RAARPTVGSLTSLA--DPPPPPPTPEPA-PHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPT 2762

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18379328   395 TQASLQSIIHKFLTAGPSAfNITSLISQAAQLSTQAQPSNQSPMSLTSDASSPRSYVSPRIS-----TPQTNTVPIKPLI 469
Cdd:PHA03247 2763 TAGPPAPAPPAAPAAGPPR-RLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASpagplPPPTSAQPTAPPP 2841

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 18379328   470 STPPVSSQPKVSTPVVKQGPVSQSA-TQQPVTADKQQGHEPVS 511
Cdd:PHA03247 2842 PPGPPPPSLPLGGSVAPGGDVRRRPpSRSPAAKPAAPARPPVR 2884
PRP40 super family cl34905
Splicing factor [RNA processing and modification];
131-198 3.16e-03

Splicing factor [RNA processing and modification];


The actual alignment was detected with superfamily member COG5104:

Pssm-ID: 227435 [Multi-domain]  Cd Length: 590  Bit Score: 40.45  E-value: 3.16e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18379328 131 SADDWSEHISSSGKKYYYNCRTEVSQWEKPKEW--LEREQRQKEA---------NKMAVNSFPKD---RDYRREVMQATA 196
Cdd:COG5104  54 DVDPWKECRTADGKVYYYNSITRESRWKIPPERkkVEPIAEQKHDersmiggngNDMAITDHETSepkYLLGRLMSQYGI 133


                ..
gi 18379328 197 TS 198
Cdd:COG5104 134 TS 135
 
Name Accession Description Interval E-value
WW pfam00397
WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds ...
 133-160 4.11e-09

WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds proline-rich peptide motifs in vitro.


Pssm-ID: 459800 [Multi-domain]  Cd Length: 30  Bit Score: 52.12  E-value: 4.11e-09
                          10        20
                  ....*....|....*....|....*...
gi 18379328   133 DDWSEHISSSGKKYYYNCRTEVSQWEKP 160
Cdd:pfam00397   3 PGWEERWDPDGRVYYYNHETGETQWEKP 30
WW cd00201
Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; ...
 133-162 1.51e-08

Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other peptide recognition proteins such as antibodies and receptors; WW domains have a single groove formed by a conserved Trp and Tyr which recognizes a pair of residues of the sequence X-Pro; variable loops and neighboring domains confer specificity in this domain; there are five distinct groups based on binding: 1) PPXY motifs 2) the PPLP motif; 3) PGM motifs; 4) PSP or PTP motifs; 5) PR motifs.


Pssm-ID: 238122 [Multi-domain]  Cd Length: 31  Bit Score: 50.60  E-value: 1.51e-08
                        10        20        30
                ....*....|....*....|....*....|
gi 18379328 133 DDWSEHISSSGKKYYYNCRTEVSQWEKPKE 162
Cdd:cd00201   2 PGWEERWDPDGRVYYYNHNTKETQWEDPRE 31
WW smart00456
Domain with 2 conserved Trp (W) residues; Also known as the WWP or rsp5 domain. Binds ...
 135-162 1.27e-06

Domain with 2 conserved Trp (W) residues; Also known as the WWP or rsp5 domain. Binds proline-rich polypeptides.


Pssm-ID: 197736 [Multi-domain]  Cd Length: 33  Bit Score: 45.28  E-value: 1.27e-06
                           10        20
                   ....*....|....*....|....*...
gi 18379328    135 WSEHISSSGKKYYYNCRTEVSQWEKPKE 162
Cdd:smart00456   6 WEERKDPDGRPYYYNHETKETQWEKPRE 33
PHA03247 PHA03247
large tegument protein UL36; Provisional
 235-511 4.68e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 50.32  E-value: 4.68e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18379328   235 PRAETHSSSTPVQHPIKPvvhPTATPSTVPSSPFTLQSDHQPKKSFDANGASTLSKLPTPTSSVPAQKTERKESTSGDKP 314
Cdd:PHA03247 2609 RGPAPPSPLPPDTHAPDP---PPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRR 2685

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18379328   315 VSHSCTTPSTSSASglNPTSAPPTSASAvPVSPVPQSPIPPLLQDPNLLRQLLPALQATLQLNNSNVDISKINEVLTAAV 394
Cdd:PHA03247 2686 RAARPTVGSLTSLA--DPPPPPPTPEPA-PHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPT 2762

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18379328   395 TQASLQSIIHKFLTAGPSAfNITSLISQAAQLSTQAQPSNQSPMSLTSDASSPRSYVSPRIS-----TPQTNTVPIKPLI 469
Cdd:PHA03247 2763 TAGPPAPAPPAAPAAGPPR-RLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASpagplPPPTSAQPTAPPP 2841

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 18379328   470 STPPVSSQPKVSTPVVKQGPVSQSA-TQQPVTADKQQGHEPVS 511
Cdd:PHA03247 2842 PPGPPPPSLPLGGSVAPGGDVRRRPpSRSPAAKPAAPARPPVR 2884
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 252-509 2.88e-04

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 43.80  E-value: 2.88e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18379328   252 PVVHPTATPSTVPSSpFTLQSDHQPKKSFDANGASTLSklpTPTSSVPAQKTERKESTSGDKPVSHSCTTPSTSSASGLN 331
Cdd:pfam17823 115 LAAAASSSPSSAAQS-LPAAIAALPSEAFSAPRAAACR---ANASAAPRAAIAAASAPHAASPAPRTAASSTTAASSTTA 190

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18379328   332 PTSAPPTSASAVPVSPVPQSPIppllqDPNLLRQLLPALQATLQLNNSNVDISKINEVLTAAVTQASLQSIIHKFLTAGP 411
Cdd:pfam17823 191 ASSAPTTAASSAPATLTPARGI-----STAATATGHPAAGTALAAVGNSSPAAGTVTAAVGTVTPAALATLAAAAGTVAS 265

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18379328   412 SAfnitSLISQAAQLSTQAQPSNQSPMSltSDASSPRSYVSPRISTPQTNTVPIKPLISTPPVSSQPKVSTPVVKQGPVS 491
Cdd:pfam17823 266 AA----GTINMGDPHARRLSPAKHMPSD--TMARNPAAPMGAQAQGPIIQVSTDQPVHNTAGEPTPSPSNTTLEPNTPKS 339

                         250
                  ....*....|....*....
gi 18379328   492 QSATQQP-VTADKQQGHEP 509
Cdd:pfam17823 340 VASTNLAvVTTTKAQAKEP 358
PRP40 COG5104
Splicing factor [RNA processing and modification];
132-168 7.72e-04

Splicing factor [RNA processing and modification];


Pssm-ID: 227435 [Multi-domain]  Cd Length: 590  Bit Score: 42.76  E-value: 7.72e-04
                        10        20        30
                ....*....|....*....|....*....|....*..
gi 18379328 132 ADDWSEHISSSGKKYYYNCRTEVSQWEKPKEWLEREQ 168
Cdd:COG5104  14 RSEWEELKAPDGRIYYYNKRTGKSSWEKPKELLKGSE 50
PRP40 COG5104
Splicing factor [RNA processing and modification];
131-198 3.16e-03

Splicing factor [RNA processing and modification];


Pssm-ID: 227435 [Multi-domain]  Cd Length: 590  Bit Score: 40.45  E-value: 3.16e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18379328 131 SADDWSEHISSSGKKYYYNCRTEVSQWEKPKEW--LEREQRQKEA---------NKMAVNSFPKD---RDYRREVMQATA 196
Cdd:COG5104  54 DVDPWKECRTADGKVYYYNSITRESRWKIPPERkkVEPIAEQKHDersmiggngNDMAITDHETSepkYLLGRLMSQYGI 133


                ..
gi 18379328 197 TS 198
Cdd:COG5104 134 TS 135
 
Name Accession Description Interval E-value
WW pfam00397
WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds ...
 133-160 4.11e-09

WW domain; The WW domain is a protein module with two highly conserved tryptophans that binds proline-rich peptide motifs in vitro.


Pssm-ID: 459800 [Multi-domain]  Cd Length: 30  Bit Score: 52.12  E-value: 4.11e-09
                          10        20
                  ....*....|....*....|....*...
gi 18379328   133 DDWSEHISSSGKKYYYNCRTEVSQWEKP 160
Cdd:pfam00397   3 PGWEERWDPDGRVYYYNHETGETQWEKP 30
WW cd00201
Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; ...
 133-162 1.51e-08

Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other peptide recognition proteins such as antibodies and receptors; WW domains have a single groove formed by a conserved Trp and Tyr which recognizes a pair of residues of the sequence X-Pro; variable loops and neighboring domains confer specificity in this domain; there are five distinct groups based on binding: 1) PPXY motifs 2) the PPLP motif; 3) PGM motifs; 4) PSP or PTP motifs; 5) PR motifs.


Pssm-ID: 238122 [Multi-domain]  Cd Length: 31  Bit Score: 50.60  E-value: 1.51e-08
                        10        20        30
                ....*....|....*....|....*....|
gi 18379328 133 DDWSEHISSSGKKYYYNCRTEVSQWEKPKE 162
Cdd:cd00201   2 PGWEERWDPDGRVYYYNHNTKETQWEDPRE 31
WW smart00456
Domain with 2 conserved Trp (W) residues; Also known as the WWP or rsp5 domain. Binds ...
 135-162 1.27e-06

Domain with 2 conserved Trp (W) residues; Also known as the WWP or rsp5 domain. Binds proline-rich polypeptides.


Pssm-ID: 197736 [Multi-domain]  Cd Length: 33  Bit Score: 45.28  E-value: 1.27e-06
                           10        20
                   ....*....|....*....|....*...
gi 18379328    135 WSEHISSSGKKYYYNCRTEVSQWEKPKE 162
Cdd:smart00456   6 WEERKDPDGRPYYYNHETKETQWEKPRE 33
PHA03247 PHA03247
large tegument protein UL36; Provisional
 235-511 4.68e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 50.32  E-value: 4.68e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18379328   235 PRAETHSSSTPVQHPIKPvvhPTATPSTVPSSPFTLQSDHQPKKSFDANGASTLSKLPTPTSSVPAQKTERKESTSGDKP 314
Cdd:PHA03247 2609 RGPAPPSPLPPDTHAPDP---PPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRR 2685

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18379328   315 VSHSCTTPSTSSASglNPTSAPPTSASAvPVSPVPQSPIPPLLQDPNLLRQLLPALQATLQLNNSNVDISKINEVLTAAV 394
Cdd:PHA03247 2686 RAARPTVGSLTSLA--DPPPPPPTPEPA-PHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPT 2762

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18379328   395 TQASLQSIIHKFLTAGPSAfNITSLISQAAQLSTQAQPSNQSPMSLTSDASSPRSYVSPRIS-----TPQTNTVPIKPLI 469
Cdd:PHA03247 2763 TAGPPAPAPPAAPAAGPPR-RLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASpagplPPPTSAQPTAPPP 2841

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 18379328   470 STPPVSSQPKVSTPVVKQGPVSQSA-TQQPVTADKQQGHEPVS 511
Cdd:PHA03247 2842 PPGPPPPSLPLGGSVAPGGDVRRRPpSRSPAAKPAAPARPPVR 2884
PHA03247 PHA03247
large tegument protein UL36; Provisional
 234-562 1.25e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 45.70  E-value: 1.25e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18379328   234 LPRAETHSSSTPVQHPIKPVVHPTATPSTVPSSPFTLQSDHQPKKSFDANGASTLSKLPTPTSSVPAQKTERKESTSGDK 313
Cdd:PHA03247 2721 LPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPS 2800

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18379328   314 PVSHSCTTPSTSSASGLNPTSAPPTSASAVPVSPVPQSPIPPLlqdpnllrqllPALQATLQLNNSNV---DISKINEVL 390
Cdd:PHA03247 2801 PWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPP-----------GPPPPSLPLGGSVApggDVRRRPPSR 2869

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18379328   391 TAAVTQASlqsiihkfltagPSAFNITSLISQAAQLSTQAQPSNQSPMsltsdassprsyvsPRISTPQTNTVPIKPLIS 470
Cdd:PHA03247 2870 SPAAKPAA------------PARPPVRRLARPAVSRSTESFALPPDQP--------------ERPPQPQAPPPPQPQPQP 2923

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18379328   471 TPPVSSQPKVSTPVVKQGPVSQSATQQPVTADKQQGHEPVSPRSLQRSSSQRSPSPGPNHTSNSSNASnATVVPQNSSAR 550
Cdd:PHA03247 2924 PPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPAS-STPPLTGHSLS 3002

                         330
                  ....*....|..
gi 18379328   551 STCSLTPALAAH 562
Cdd:PHA03247 3003 RVSSWASSLALH 3014
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 252-509 2.88e-04

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 43.80  E-value: 2.88e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18379328   252 PVVHPTATPSTVPSSpFTLQSDHQPKKSFDANGASTLSklpTPTSSVPAQKTERKESTSGDKPVSHSCTTPSTSSASGLN 331
Cdd:pfam17823 115 LAAAASSSPSSAAQS-LPAAIAALPSEAFSAPRAAACR---ANASAAPRAAIAAASAPHAASPAPRTAASSTTAASSTTA 190

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18379328   332 PTSAPPTSASAVPVSPVPQSPIppllqDPNLLRQLLPALQATLQLNNSNVDISKINEVLTAAVTQASLQSIIHKFLTAGP 411
Cdd:pfam17823 191 ASSAPTTAASSAPATLTPARGI-----STAATATGHPAAGTALAAVGNSSPAAGTVTAAVGTVTPAALATLAAAAGTVAS 265

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18379328   412 SAfnitSLISQAAQLSTQAQPSNQSPMSltSDASSPRSYVSPRISTPQTNTVPIKPLISTPPVSSQPKVSTPVVKQGPVS 491
Cdd:pfam17823 266 AA----GTINMGDPHARRLSPAKHMPSD--TMARNPAAPMGAQAQGPIIQVSTDQPVHNTAGEPTPSPSNTTLEPNTPKS 339

                         250
                  ....*....|....*....
gi 18379328   492 QSATQQP-VTADKQQGHEP 509
Cdd:pfam17823 340 VASTNLAvVTTTKAQAKEP 358
PRP40 COG5104
Splicing factor [RNA processing and modification];
132-168 7.72e-04

Splicing factor [RNA processing and modification];


Pssm-ID: 227435 [Multi-domain]  Cd Length: 590  Bit Score: 42.76  E-value: 7.72e-04
                        10        20        30
                ....*....|....*....|....*....|....*..
gi 18379328 132 ADDWSEHISSSGKKYYYNCRTEVSQWEKPKEWLEREQ 168
Cdd:COG5104  14 RSEWEELKAPDGRIYYYNKRTGKSSWEKPKELLKGSE 50
PRP40 COG5104
Splicing factor [RNA processing and modification];
131-198 3.16e-03

Splicing factor [RNA processing and modification];


Pssm-ID: 227435 [Multi-domain]  Cd Length: 590  Bit Score: 40.45  E-value: 3.16e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18379328 131 SADDWSEHISSSGKKYYYNCRTEVSQWEKPKEW--LEREQRQKEA---------NKMAVNSFPKD---RDYRREVMQATA 196
Cdd:COG5104  54 DVDPWKECRTADGKVYYYNSITRESRWKIPPERkkVEPIAEQKHDersmiggngNDMAITDHETSepkYLLGRLMSQYGI 133


                ..
gi 18379328 197 TS 198
Cdd:COG5104 134 TS 135
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 212-571 5.96e-03

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 39.90  E-value: 5.96e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18379328   212 ASSLLPQNILSQTSRHNDRDYRLPRAETHSSSTPVQHPIKPVVHPTAT----------PSTVPSSPFTLQSDHQPKKSFD 281
Cdd:pfam05109 311 ASQDMPTNTTDITYVGDNATYSVPMVTSEDANSPNVTVTAFWAWPNNTetdfkckwtlTSGTPSGCENISGAFASNRTFD 390

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18379328   282 AngasTLSKLPTPTSSVPAQKTERKESTSGDKpVSHSCTTPSTSSASGLNPTS-APPTSASAVPVSP-VPQSPIPPLLQD 359
Cdd:pfam05109 391 I----TVSGLGTAPKTLIITRTATNATTTTHK-VIFSKAPESTTTSPTLNTTGfAAPNTTTGLPSSThVPTNLTAPASTG 465

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18379328   360 PNLlrqllpalqatlqlnnSNVDISKINEVLT---AAVTQASLQSIIHKFLTAGPSAFNITSLISQAAQLSTQAQPSNQS 436
Cdd:pfam05109 466 PTV----------------STADVTSPTPAGTtsgASPVTPSPSPRDNGTESKAPDMTSPTSAVTTPTPNATSPTPAVTT 529

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18379328   437 PmslTSDASSP---RSYVSPRISTPQTNTVPIKPLISTPpvssQPKVSTPVV-KQGPVSQSATQQPVTADKQQGHepVSP 512
Cdd:pfam05109 530 P---TPNATSPtlgKTSPTSAVTTPTPNATSPTPAVTTP----TPNATIPTLgKTSPTSAVTTPTPNATSPTVGE--TSP 600

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 18379328   513 RSLQRSSSQRSPSPGPNHTSNSSNASNATVVPQN---SSARSTCSLTPA-----LAAHFSENLIKHV 571
Cdd:pfam05109 601 QANTTNHTLGGTSSTPVVTSPPKNATSAVTTGQHnitSSSTSSMSLRPSsisetLSPSTSDNSTSHM 667
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 259-556 6.66e-03

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 39.51  E-value: 6.66e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18379328   259 TPSTVPSSPFTLQSDHQPKKSFDANGASTLSKLPTPTSSVPAQKTE---RKESTSGDKPVSH--------SCTTPSTSSA 327
Cdd:pfam05109 392 TVSGLGTAPKTLIITRTATNATTTTHKVIFSKAPESTTTSPTLNTTgfaAPNTTTGLPSSTHvptnltapASTGPTVSTA 471

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18379328   328 SGLNPTSAPPTSAsAVPVSPVP-------QSPIPPLLQDPNLLRQLLPalqatlqlNNSNVDISKINEVLTAAVTQASLQ 400
Cdd:pfam05109 472 DVTSPTPAGTTSG-ASPVTPSPsprdngtESKAPDMTSPTSAVTTPTP--------NATSPTPAVTTPTPNATSPTLGKT 542

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18379328   401 SIIHKFLTAGPSAFNITSLISQAAQLSTQAQPSNQSPMSLTSDASSPRSYVSPRISTPQTNTV--PIKPLISTPPVSSQP 478
Cdd:pfam05109 543 SPTSAVTTPTPNATSPTPAVTTPTPNATIPTLGKTSPTSAVTTPTPNATSPTVGETSPQANTTnhTLGGTSSTPVVTSPP 622

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 18379328   479 KVSTPVVKQG---------------PVSQSATQQPVTADKQQGHEPV----SPRSLQRSSSQRSPSPGPNHTSNSSNASN 539
Cdd:pfam05109 623 KNATSAVTTGqhnitssstssmslrPSSISETLSPSTSDNSTSHMPLltsaHPTGGENITQVTPASTSTHHVSTSSPAPR 702

                         330
                  ....*....|....*..
gi 18379328   540 ATVVPQNSSARSTCSLT 556
Cdd:pfam05109 703 PGTTSQASGPGNSSTST 719
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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