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Conserved domains on  [gi|21703710|ref|NP_057563|]
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protein shisa-5 isoform a precursor [Homo sapiens]

Protein Classification

shisa family protein( domain architecture ID 10621415)

shisa family protein is a transcription factor-type molecule that physically interacts with immature forms of the Wnt receptor Frizzled and the FGF receptor within the endoplasmic reticulum to inhibit their post-translational maturation and trafficking to the cell surface

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Shisa pfam13908
Wnt and FGF inhibitory regulator; Shisa is a transcription factor-type molecule that ...
 28-209 1.03e-31

Wnt and FGF inhibitory regulator; Shisa is a transcription factor-type molecule that physically interacts with immature forms of the Wnt receptor Frizzled and the FGF receptor within the endoplasmic reticulum to inhibit their post-translational maturation and trafficking to the cell surface.


:

Pssm-ID: 464036  Cd Length: 187  Bit Score: 114.92  E-value: 1.03e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703710    28 GEVCMA---SRGLSLFPESCPD----FCCGTCDDQYCCSDVLKKFV---------WSEERCAVPEASVPaSVEPVEQLGS 91
Cdd:pfam13908   1 GEYCHGwfdSMGQWHEGFQCPErdatFCCGSCSLRYCCSDVLARLDqgtctndrrWMETGKEPPEAPDS-TAEPIYVPFL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703710    92 ALrfrpgyndpmsgfGATLAVGLTIFVLSVVTIIICFTCSCCCLYKTCRRPRPVVTTTTSTTVVHAPYPQPPSVPPSYPG 171
Cdd:pfam13908  80 AL-------------GLIVAIGGSVFVAFVIVGIFCATCCCCCLYKMCRRPRPVVTTTTTTTVVETPYPQPPSAPPSYPG 146

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 21703710   172 PSYQGYHTMP--PQPGMPAAPYPM-QYPPPYPAQPMGPPAY 209
Cdd:pfam13908 147 PSYQGYTPMPssSQPGMPAAPYPTqYPPPYPAQLPMGPPPY 187
 
Name Accession Description Interval E-value
Shisa pfam13908
Wnt and FGF inhibitory regulator; Shisa is a transcription factor-type molecule that ...
 28-209 1.03e-31

Wnt and FGF inhibitory regulator; Shisa is a transcription factor-type molecule that physically interacts with immature forms of the Wnt receptor Frizzled and the FGF receptor within the endoplasmic reticulum to inhibit their post-translational maturation and trafficking to the cell surface.


Pssm-ID: 464036  Cd Length: 187  Bit Score: 114.92  E-value: 1.03e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703710    28 GEVCMA---SRGLSLFPESCPD----FCCGTCDDQYCCSDVLKKFV---------WSEERCAVPEASVPaSVEPVEQLGS 91
Cdd:pfam13908   1 GEYCHGwfdSMGQWHEGFQCPErdatFCCGSCSLRYCCSDVLARLDqgtctndrrWMETGKEPPEAPDS-TAEPIYVPFL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703710    92 ALrfrpgyndpmsgfGATLAVGLTIFVLSVVTIIICFTCSCCCLYKTCRRPRPVVTTTTSTTVVHAPYPQPPSVPPSYPG 171
Cdd:pfam13908  80 AL-------------GLIVAIGGSVFVAFVIVGIFCATCCCCCLYKMCRRPRPVVTTTTTTTVVETPYPQPPSAPPSYPG 146

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 21703710   172 PSYQGYHTMP--PQPGMPAAPYPM-QYPPPYPAQPMGPPAY 209
Cdd:pfam13908 147 PSYQGYTPMPssSQPGMPAAPYPTqYPPPYPAQLPMGPPPY 187
 
Name Accession Description Interval E-value
Shisa pfam13908
Wnt and FGF inhibitory regulator; Shisa is a transcription factor-type molecule that ...
 28-209 1.03e-31

Wnt and FGF inhibitory regulator; Shisa is a transcription factor-type molecule that physically interacts with immature forms of the Wnt receptor Frizzled and the FGF receptor within the endoplasmic reticulum to inhibit their post-translational maturation and trafficking to the cell surface.


Pssm-ID: 464036  Cd Length: 187  Bit Score: 114.92  E-value: 1.03e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703710    28 GEVCMA---SRGLSLFPESCPD----FCCGTCDDQYCCSDVLKKFV---------WSEERCAVPEASVPaSVEPVEQLGS 91
Cdd:pfam13908   1 GEYCHGwfdSMGQWHEGFQCPErdatFCCGSCSLRYCCSDVLARLDqgtctndrrWMETGKEPPEAPDS-TAEPIYVPFL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21703710    92 ALrfrpgyndpmsgfGATLAVGLTIFVLSVVTIIICFTCSCCCLYKTCRRPRPVVTTTTSTTVVHAPYPQPPSVPPSYPG 171
Cdd:pfam13908  80 AL-------------GLIVAIGGSVFVAFVIVGIFCATCCCCCLYKMCRRPRPVVTTTTTTTVVETPYPQPPSAPPSYPG 146

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 21703710   172 PSYQGYHTMP--PQPGMPAAPYPM-QYPPPYPAQPMGPPAY 209
Cdd:pfam13908 147 PSYQGYTPMPssSQPGMPAAPYPTqYPPPYPAQLPMGPPPY 187
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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