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Conserved domains on  [gi|7706379|ref|NP_057200|]
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ankyrin repeat and SOCS box protein 4 isoform a [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1-289 1.18e-28

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 113.90  E-value: 1.18e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706379    1 MDGTTAPVTKSGAAKLVKRNFLEALKSNDFGKLKAILIQRQIDVDTVFEVEDENMVLASYKQGYWLPSYKLKSSWATGLH 80
Cdd:COG0666  13 AALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLH 92

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706379   81 LSVLFGHVECLLVLLDHNATINCR-PNGKTPLHVACEMANVDCVKILCDRGAKLNCYSLSGHTALHFCTTPSSILCAKQL 159
Cdd:COG0666  93 AAARNGDLEIVKLLLEAGADVNARdKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLL 172

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706379  160 VWRGANVNMKtnNQDEETPLHTAAHFGLSELVAFYVEHGAIVDSVNAHMETPLAIAAYWalrfkeqeystEHHLVCRMLL 239
Cdd:COG0666 173 LEAGADVNAR--DNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAEN-----------GNLEIVKLLL 239

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 7706379  240 DYKAEVNARDDDFKSPLHKAAWNCDHVLMHMMLEAGAEANLMDINGCAAI 289
Cdd:COG0666 240 EAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
SOCS_ASB4_ASB18 cd03723
SOCS (suppressors of cytokine signaling) box of ASB4 and ASB18 proteins. ASB family members ...
 379-426 3.07e-15

SOCS (suppressors of cytokine signaling) box of ASB4 and ASB18 proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Asb4 was identified as imprinted gene in mice. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


:

Pssm-ID: 239693  Cd Length: 48  Bit Score: 69.39  E-value: 3.07e-15
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*...
gi 7706379  379 NSPRTLMHLSRCAIRRTLHNRCHRAIPLLSLPLSLKKYLLLEPEGIIY 426
Cdd:cd03723   1 GTPRSLQHLCRCAIRKLLGSRCHKLVPQLSLPTSLKNYLLLEPEGVLY 48
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1-289 1.18e-28

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 113.90  E-value: 1.18e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706379    1 MDGTTAPVTKSGAAKLVKRNFLEALKSNDFGKLKAILIQRQIDVDTVFEVEDENMVLASYKQGYWLPSYKLKSSWATGLH 80
Cdd:COG0666  13 AALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLH 92

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706379   81 LSVLFGHVECLLVLLDHNATINCR-PNGKTPLHVACEMANVDCVKILCDRGAKLNCYSLSGHTALHFCTTPSSILCAKQL 159
Cdd:COG0666  93 AAARNGDLEIVKLLLEAGADVNARdKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLL 172

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706379  160 VWRGANVNMKtnNQDEETPLHTAAHFGLSELVAFYVEHGAIVDSVNAHMETPLAIAAYWalrfkeqeystEHHLVCRMLL 239
Cdd:COG0666 173 LEAGADVNAR--DNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAEN-----------GNLEIVKLLL 239

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 7706379  240 DYKAEVNARDDDFKSPLHKAAWNCDHVLMHMMLEAGAEANLMDINGCAAI 289
Cdd:COG0666 240 EAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
SOCS_ASB4_ASB18 cd03723
SOCS (suppressors of cytokine signaling) box of ASB4 and ASB18 proteins. ASB family members ...
 379-426 3.07e-15

SOCS (suppressors of cytokine signaling) box of ASB4 and ASB18 proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Asb4 was identified as imprinted gene in mice. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239693  Cd Length: 48  Bit Score: 69.39  E-value: 3.07e-15
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*...
gi 7706379  379 NSPRTLMHLSRCAIRRTLHNRCHRAIPLLSLPLSLKKYLLLEPEGIIY 426
Cdd:cd03723   1 GTPRSLQHLCRCAIRKLLGSRCHKLVPQLSLPTSLKNYLLLEPEGVLY 48
PHA03095 PHA03095
ankyrin-like protein; Provisional
 80-321 1.04e-13

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 72.75  E-value: 1.04e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706379    80 HLSVLFGHVECLLVLLDHNATINCRPN-GKTPLHVACEM--ANVDCVKILCDRGAKLNCYSLSGHTALH-FCTTP-SSIL 154
Cdd:PHA03095 124 YLSGFNINPKVIRLLLRKGADVNALDLyGMTPLAVLLKSrnANVELLRLLIDAGADVYAVDDRFRSLLHhHLQSFkPRAR 203

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706379   155 CAKQLVWRGANVNmkTNNQDEETPLHTAAHFGLSE--LVAFYVEHGAIVDSVNAHMETPLAIAAYwalrfkeqeysTEHH 232
Cdd:PHA03095 204 IVRELIRAGCDPA--ATDMLGNTPLHSMATGSSCKrsLVLPLLIAGISINARNRYGQTPLHYAAV-----------FNNP 270

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706379   233 LVCRMLLDYKAEVNARDDDFKSPLHKAAWNCDHVLMHMMLEAGAEANLMDingcAAIQYVLKVTSVRPAAQPEICYQLLL 312
Cdd:PHA03095 271 RACRRLIALGADINAVSSDGNTPLSLMVRNNNGRAVRAALAKNPSAETVA----ATLNTASVAGGDIPSDATRLCVAKVV 346


                 ....*....
gi 7706379   313 NHGAARIYP 321
Cdd:PHA03095 347 LRGAFSLLP 355
Ank_2 pfam12796
Ankyrin repeats (3 copies);
79-169 1.35e-13

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 66.29  E-value: 1.35e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706379     79 LHLSVLFGHVECLLVLLDHNATINCR-PNGKTPLHVACEMANVDCVKILCDRGAKLNCysLSGHTALHFCTTPSSILCAK 157
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQdKNGRTALHLAAKNGHLEIVKLLLEHADVNLK--DNGRTALHYAARSGHLEIVK 78

                          90
                  ....*....|..
gi 7706379    158 QLVWRGANVNMK 169
Cdd:pfam12796  79 LLLEKGADINVK 90
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 106-135 1.80e-05

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 41.42  E-value: 1.80e-05
                           10        20        30
                   ....*....|....*....|....*....|
gi 7706379     106 NGKTPLHVACEMANVDCVKILCDRGAKLNC 135
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
SOCS_box pfam07525
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more ...
 380-404 2.13e-05

SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.


Pssm-ID: 462192  Cd Length: 39  Bit Score: 41.38  E-value: 2.13e-05
                          10        20
                  ....*....|....*....|....*
gi 7706379    380 SPRTLMHLSRCAIRRTLHNRCHRAI 404
Cdd:pfam07525   1 TPRSLQHLCRLAIRRALGKRRLGAI 25
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 77-180 1.82e-04

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 43.85  E-value: 1.82e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706379   77 TGLHLSVLFGHVECLLVLLDH-----NATINCRP-NGKTPLHVACEMANVDCVKILCDRGAKLN-------CYSLSGHTA 143
Cdd:cd22192  53 TALHVAALYDNLEAAVVLMEAapelvNEPMTSDLyQGETALHIAVVNQNLNLVRELIARGADVVspratgtFFRPGPKNL 132

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 7706379  144 LHF---------CTTPSSILcaKQLVWRGANvnmkTNNQDE--ETPLH 180
Cdd:cd22192 133 IYYgehplsfaaCVGNEEIV--RLLIEHGAD----IRAQDSlgNTVLH 174
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1-289 1.18e-28

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 113.90  E-value: 1.18e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706379    1 MDGTTAPVTKSGAAKLVKRNFLEALKSNDFGKLKAILIQRQIDVDTVFEVEDENMVLASYKQGYWLPSYKLKSSWATGLH 80
Cdd:COG0666  13 AALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLH 92

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706379   81 LSVLFGHVECLLVLLDHNATINCR-PNGKTPLHVACEMANVDCVKILCDRGAKLNCYSLSGHTALHFCTTPSSILCAKQL 159
Cdd:COG0666  93 AAARNGDLEIVKLLLEAGADVNARdKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLL 172

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706379  160 VWRGANVNMKtnNQDEETPLHTAAHFGLSELVAFYVEHGAIVDSVNAHMETPLAIAAYWalrfkeqeystEHHLVCRMLL 239
Cdd:COG0666 173 LEAGADVNAR--DNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAEN-----------GNLEIVKLLL 239

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 7706379  240 DYKAEVNARDDDFKSPLHKAAWNCDHVLMHMMLEAGAEANLMDINGCAAI 289
Cdd:COG0666 240 EAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
76-294 3.48e-28

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 112.74  E-value: 3.48e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706379   76 ATGLHLSVLFGHVECLLVLLDHNATINCR-PNGKTPLHVACEMANVDCVKILCDRGAKLNCYSLSGHTALHFCTTPSSIL 154
Cdd:COG0666  55 ALLLLAAALAGDLLVALLLLAAGADINAKdDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLE 134

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706379  155 CAKQLVWRGANVNMKTNNQdeETPLHTAAHFGLSELVAFYVEHGAIVDSVNAHMETPLAIAAYwalrfkeqeysTEHHLV 234
Cdd:COG0666 135 IVKLLLEAGADVNAQDNDG--NTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAE-----------NGHLEI 201

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706379  235 CRMLLDYKAEVNARDDDFKSPLHKAAWNCDHVLMHMMLEAGAEANLMDINGCAAIQYVLK 294
Cdd:COG0666 202 VKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAA 261
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
71-291 1.77e-24

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 102.34  E-value: 1.77e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706379   71 LKSSWATGLHLSVLFGHVECLLVLLDHNATINCRPNGKTPLHVACEMANVDCVKILCDRGAKLNCYSLSGHTALHFCTTP 150
Cdd:COG0666  18 LLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARN 97

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706379  151 SSILCAKQLVWRGANVNMKtnNQDEETPLHTAAHFGLSELVAFYVEHGAIVDSVNAHMETPLAIAAYwalrfkeqeystE 230
Cdd:COG0666  98 GDLEIVKLLLEAGADVNAR--DKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAA------------N 163

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 7706379  231 HHL-VCRMLLDYKAEVNARDDDFKSPLHKAAWNCDHVLMHMMLEAGAEANLMDINGCAAIQY 291
Cdd:COG0666 164 GNLeIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDL 225
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
91-316 1.60e-20

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 91.17  E-value: 1.60e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706379   91 LLVLLDHNATINCRPNGKTPLHVACEMANVDCVKILCDRGAKLNCYSLSGHTALHFCTTPSSILCAKQLVWRGANVNMKT 170
Cdd:COG0666   5 LLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKD 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706379  171 NNQdeETPLHTAAHFGLSELVAFYVEHGAIVDSVNAHMETPLAIAAYwalrfkeqeysTEHHLVCRMLLDYKAEVNARDD 250
Cdd:COG0666  85 DGG--NTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAY-----------NGNLEIVKLLLEAGADVNAQDN 151

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 7706379  251 DFKSPLHKAAWNCDHVLMHMMLEAGAEANLMDINGCAAIQYvlkvtsvrpAAQ---PEICyQLLLNHGA 316
Cdd:COG0666 152 DGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHL---------AAEnghLEIV-KLLLEAGA 210
SOCS_ASB4_ASB18 cd03723
SOCS (suppressors of cytokine signaling) box of ASB4 and ASB18 proteins. ASB family members ...
 379-426 3.07e-15

SOCS (suppressors of cytokine signaling) box of ASB4 and ASB18 proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Asb4 was identified as imprinted gene in mice. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239693  Cd Length: 48  Bit Score: 69.39  E-value: 3.07e-15
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*...
gi 7706379  379 NSPRTLMHLSRCAIRRTLHNRCHRAIPLLSLPLSLKKYLLLEPEGIIY 426
Cdd:cd03723   1 GTPRSLQHLCRCAIRKLLGSRCHKLVPQLSLPTSLKNYLLLEPEGVLY 48
PHA03095 PHA03095
ankyrin-like protein; Provisional
 80-321 1.04e-13

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 72.75  E-value: 1.04e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706379    80 HLSVLFGHVECLLVLLDHNATINCRPN-GKTPLHVACEM--ANVDCVKILCDRGAKLNCYSLSGHTALH-FCTTP-SSIL 154
Cdd:PHA03095 124 YLSGFNINPKVIRLLLRKGADVNALDLyGMTPLAVLLKSrnANVELLRLLIDAGADVYAVDDRFRSLLHhHLQSFkPRAR 203

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706379   155 CAKQLVWRGANVNmkTNNQDEETPLHTAAHFGLSE--LVAFYVEHGAIVDSVNAHMETPLAIAAYwalrfkeqeysTEHH 232
Cdd:PHA03095 204 IVRELIRAGCDPA--ATDMLGNTPLHSMATGSSCKrsLVLPLLIAGISINARNRYGQTPLHYAAV-----------FNNP 270

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706379   233 LVCRMLLDYKAEVNARDDDFKSPLHKAAWNCDHVLMHMMLEAGAEANLMDingcAAIQYVLKVTSVRPAAQPEICYQLLL 312
Cdd:PHA03095 271 RACRRLIALGADINAVSSDGNTPLSLMVRNNNGRAVRAALAKNPSAETVA----ATLNTASVAGGDIPSDATRLCVAKVV 346


                 ....*....
gi 7706379   313 NHGAARIYP 321
Cdd:PHA03095 347 LRGAFSLLP 355
Ank_2 pfam12796
Ankyrin repeats (3 copies);
79-169 1.35e-13

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 66.29  E-value: 1.35e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706379     79 LHLSVLFGHVECLLVLLDHNATINCR-PNGKTPLHVACEMANVDCVKILCDRGAKLNCysLSGHTALHFCTTPSSILCAK 157
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQdKNGRTALHLAAKNGHLEIVKLLLEHADVNLK--DNGRTALHYAARSGHLEIVK 78

                          90
                  ....*....|..
gi 7706379    158 QLVWRGANVNMK 169
Cdd:pfam12796  79 LLLEKGADINVK 90
PHA03095 PHA03095
ankyrin-like protein; Provisional
 94-299 4.41e-13

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 70.82  E-value: 4.41e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706379    94 LLDHNATINCR-PNGKTPLHVACEMANVDCVKI---LCDRGAKLNCYSLSGHTALHFCTTPSSIL-CAKQLVWRGANVNM 168
Cdd:PHA03095  33 LLAAGADVNFRgEYGKTPLHLYLHYSSEKVKDIvrlLLEAGADVNAPERCGFTPLHLYLYNATTLdVIKLLIKAGADVNA 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706379   169 KTNNQDeeTPLHT-----AAHFGlseLVAFYVEHGAIVDSVNAHMETPLAIaaywALRFKEQEYSTehhlvCRMLLDYKA 243
Cdd:PHA03095 113 KDKVGR--TPLHVylsgfNINPK---VIRLLLRKGADVNALDLYGMTPLAV----LLKSRNANVEL-----LRLLIDAGA 178

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 7706379   244 EVNARDDDFKSPLHKAAWNC--DHVLMHMMLEAGAEANLMDINGCAAIQYVLKVTSVR 299
Cdd:PHA03095 179 DVYAVDDRFRSLLHHHLQSFkpRARIVRELIRAGCDPAATDMLGNTPLHSMATGSSCK 236
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 93-316 1.14e-12

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 69.71  E-value: 1.14e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706379    93 VLLDHNATINCRP-NGKTPLHVACEMANVDCVKILCDRGAKLNCYSLSGHTALHFCTTPSSILCAKQLVWRGANVNMK-- 169
Cdd:PHA02876 163 MLLEGGADVNAKDiYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIIDNRSNINKNdl 242

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706379   170 -----TNNQDEE--------------------TPLHTAAHF-GLSELVAFYVEHGAIVDSVNAHMETPLAIAAywalrfk 223
Cdd:PHA02876 243 sllkaIRNEDLEtslllydagfsvnsiddcknTPLHHASQApSLSRLVPKLLERGADVNAKNIKGETPLYLMA------- 315

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706379   224 EQEYSTEHhlvCRMLLDYKAEVNARDDDFKSPLHKAAW---NCDHVLmhMMLEAGAEANLMDINGCAAIQYVLKVTSVrp 300
Cdd:PHA02876 316 KNGYDTEN---IRTLIMLGADVNAADRLYITPLHQASTldrNKDIVI--TLLELGANVNARDYCDKTPIHYAAVRNNV-- 388

                        250
                 ....*....|....*.
gi 7706379   301 aaqpeICYQLLLNHGA 316
Cdd:PHA02876 389 -----VIINTLLDYGA 399
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 61-282 2.25e-12

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 68.15  E-value: 2.25e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706379    61 KQGYWLPSYKLKSSwaTGLHLSVLFGHV-----ECLLVLLDHNATIN-CRPNGKTPLHVA--CEMANVDCVKILCDRGAK 132
Cdd:PHA03100  56 DNGADINSSTKNNS--TPLHYLSNIKYNltdvkEIVKLLLEYGANVNaPDNNGITPLLYAisKKSNSYSIVEYLLDNGAN 133

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706379   133 LNCYSLSGHTALHF----CTTPSSILcaKQLVWRGANVNMKTNnqdeetplhtaahfglselVAFYVEHGAIVDSVNAHM 208
Cdd:PHA03100 134 VNIKNSDGENLLHLylesNKIDLKIL--KLLIDKGVDINAKNR-------------------VNYLLSYGVPINIKDVYG 192

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 7706379   209 ETPLAIAAYwalrfkeqeysTEHHLVCRMLLDYKAEVNARDDDFKSPLHKAAWNCDHVLMHMMLEAGAEANLMD 282
Cdd:PHA03100 193 FTPLHYAVY-----------NNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPSIKTII 255
Ank_2 pfam12796
Ankyrin repeats (3 copies);
77-134 1.71e-11

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 60.13  E-value: 1.71e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 7706379     77 TGLHLSVLFGHVECLLVLLDHnATINCRPNGKTPLHVACEMANVDCVKILCDRGAKLN 134
Cdd:pfam12796  32 TALHLAAKNGHLEIVKLLLEH-ADVNLKDNGRTALHYAARSGHLEIVKLLLEKGADIN 88
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 109-285 3.42e-11

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 64.69  E-value: 3.42e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706379   109 TPLHVACEMANVDCVKILCDRGAKLNCYSLSGHTALHFCTTPSSIL-----CAKQLVWRGANVNMKTNNQDeeTPLHTAA 183
Cdd:PHA03100  37 LPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHYLSNIKYNLtdvkeIVKLLLEYGANVNAPDNNGI--TPLLYAI 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706379   184 --HFGLSELVAFYVEHGAIVDSVNAHMETPLAIAAywalrfkeqEYSTEHHLVCRMLLDYKAEVNA-------------- 247
Cdd:PHA03100 115 skKSNSYSIVEYLLDNGANVNIKNSDGENLLHLYL---------ESNKIDLKILKLLIDKGVDINAknrvnyllsygvpi 185

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 7706379   248 --RDDDFKSPLHKAAWNCDHVLMHMMLEAGAEANLMDING 285
Cdd:PHA03100 186 niKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYG 225
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 24-283 5.56e-11

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 64.31  E-value: 5.56e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706379    24 ALKSNDFGKLKAILIQR----QIDVDTVFEVEDENM--VLASYKQGYWLPSYKLKSSwaTGLHLSVLFGHVECLL-VLLD 96
Cdd:PHA02876 218 AVDSKNIDTIKAIIDNRsninKNDLSLLKAIRNEDLetSLLLYDAGFSVNSIDDCKN--TPLHHASQAPSLSRLVpKLLE 295

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706379    97 HNATINCRP-NGKTPLHVACEMA-NVDCVKILCDRGAKLNCYSLSGHTALHFCTT----PSSILCAKQLvwrGANVNMKt 170
Cdd:PHA02876 296 RGADVNAKNiKGETPLYLMAKNGyDTENIRTLIMLGADVNAADRLYITPLHQASTldrnKDIVITLLEL---GANVNAR- 371

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706379   171 nNQDEETPLHTAAHFGLSELVAFYVEHGAIVDSVNAHMETPLAIAAYwalrfkeqeySTEHHLVCRMLLDYKAEVNARDD 250
Cdd:PHA02876 372 -DYCDKTPIHYAAVRNNVVIINTLLDYGADIEALSQKIGTALHFALC----------GTNPYMSVKTLIDRGANVNSKNK 440

                        250       260       270
                 ....*....|....*....|....*....|....
gi 7706379   251 DFKSPLHKAAW-NCDHVLMHMMLEAGAEANLMDI 283
Cdd:PHA02876 441 DLSTPLHYACKkNCKLDVIEMLLDNGADVNAINI 474
Ank_2 pfam12796
Ankyrin repeats (3 copies);
111-205 2.76e-10

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 56.66  E-value: 2.76e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706379    111 LHVACEMANVDCVKILCDRGAKLNCYSLSGHTALHFCTTPSSILCAKQLVwRGANVNMKTNNqdeETPLHTAAHFGLSEL 190
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLL-EHADVNLKDNG---RTALHYAARSGHLEI 76

                          90
                  ....*....|....*
gi 7706379    191 VAFYVEHGAIVDSVN 205
Cdd:pfam12796  77 VKLLLEKGADINVKD 91
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 77-259 2.96e-10

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 61.90  E-value: 2.96e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706379    77 TGLHLSVLFGHVECLLVLLDHNATINCRP-NGKTPLHVACEMANVDCVKILCDRGAKLNCYSLSGHTALHFCTTPSSILC 155
Cdd:PHA02874 126 TFLHYAIKKGDLESIKMLFEYGADVNIEDdNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYAC 205

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706379   156 AKQLVWRGANVNMKTNNQdeETPLHTAAHFGLSeLVAFYVEHGAIVDS-VNAHmeTPLaiaaYWALrfkeqEYSTEHHLV 234
Cdd:PHA02874 206 IKLLIDHGNHIMNKCKNG--FTPLHNAIIHNRS-AIELLINNASINDQdIDGS--TPL----HHAI-----NPPCDIDII 271

                        170       180
                 ....*....|....*....|....*
gi 7706379   235 cRMLLDYKAEVNARDDDFKSPLHKA 259
Cdd:PHA02874 272 -DILLYHKADISIKDNKGENPIDTA 295
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 94-313 8.52e-10

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 60.36  E-value: 8.52e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706379    94 LLDHNATINCR-PNGKTPLHVACEMANVDCVKILCDRGAKLNCYSLSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNN 172
Cdd:PHA02874 110 ILDCGIDVNIKdAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNN 189

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706379   173 QdeETPLHTAAHFGLSELVAFYVEHGAIVDSVNAHMETPLAIAAYwalrfkeqeysteHHLVCRMLLDYKAEVNARDDDF 252
Cdd:PHA02874 190 G--ESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAII-------------HNRSAIELLINNASINDQDIDG 254

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 7706379   253 KSPLHKA-AWNCDHVLMHMMLEAGAEANLMDINGCAAIQYVLKVTSVRPAAQPEICYQLLLN 313
Cdd:PHA02874 255 STPLHHAiNPPCDIDIIDILLYHKADISIKDNKGENPIDTAFKYINKDPVIKDIIANAVLIK 316
PHA03095 PHA03095
ankyrin-like protein; Provisional
 77-291 5.71e-09

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 57.73  E-value: 5.71e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706379    77 TGLHLSVLFGHVEC---LLVLLDHNATINCRP-NGKTPLHVACEMANV-DCVKILCDRGAKLNCYSLSGHTALH-----F 146
Cdd:PHA03095  49 TPLHLYLHYSSEKVkdiVRLLLEAGADVNAPErCGFTPLHLYLYNATTlDVIKLLIKAGADVNAKDKVGRTPLHvylsgF 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706379   147 CTTPSSIlcaKQLVWRGANVNMKTNNqdeetpLHTAAHFGLS------ELVAFYVEHGAIVDSVNAHMETPLaiaaywal 220
Cdd:PHA03095 129 NINPKVI---RLLLRKGADVNALDLY------GMTPLAVLLKsrnanvELLRLLIDAGADVYAVDDRFRSLL-------- 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706379   221 rfkeqeystEHHL--------VCRMLLDYKAEVNARDDDFKSPLHKAAW--NCDHVLMHMMLEAGAEANLMDINGCAAIQ 290
Cdd:PHA03095 192 ---------HHHLqsfkprarIVRELIRAGCDPAATDMLGNTPLHSMATgsSCKRSLVLPLLIAGISINARNRYGQTPLH 262


                 .
gi 7706379   291 Y 291
Cdd:PHA03095 263 Y 263
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 93-259 6.63e-08

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 54.50  E-value: 6.63e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706379    93 VLLDHNATINC--RPNGKTPLHVACEMANVDCVKILCDRGAKLNCYSLSGHTALHFCTTPSSILCAKQLVWRGANVNMKt 170
Cdd:PHA02878 152 LLLSYGADINMkdRHKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDAR- 230

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706379   171 nNQDEETPLHTAAHFGLS-ELVAFYVEHGAivdSVNAHMETPLAIAAYWALRFKEqeystehhlVCRMLLDYKAEVNARD 249
Cdd:PHA02878 231 -DKCGNTPLHISVGYCKDyDILKLLLEHGV---DVNAKSYILGLTALHSSIKSER---------KLKLLLEYGADINSLN 297

                        170
                 ....*....|
gi 7706379   250 DDFKSPLHKA 259
Cdd:PHA02878 298 SYKLTPLSSA 307
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 79-281 1.29e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 53.46  E-value: 1.29e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706379    79 LHLSVLFGHVECLLVLLDHNATIN--CRPNGKTPLHVACEMANVDCVKILCDRGAklncyslsghtalhfcttpssilca 156
Cdd:PHA02875  72 LHDAVEEGDVKAVEELLDLGKFADdvFYKDGMTPLHLATILKKLDIMKLLIARGA------------------------- 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706379   157 kqlvwrganvNMKTNNQDEETPLHTAAHFGLSELVAFYVEHGAIVDSVNAHMETPLAIaaywALRFKEQEystehhlVCR 236
Cdd:PHA02875 127 ----------DPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLII----AMAKGDIA-------ICK 185

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 7706379   237 MLLDYKAEVN--ARDDDFkSPLHKAAWNCDHVLMHMMLEAGAEANLM 281
Cdd:PHA02875 186 MLLDSGANIDyfGKNGCV-AALCYAIENNKIDIVRLFIKRGADCNIM 231
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 54-289 2.02e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 52.69  E-value: 2.02e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706379    54 NMVLASYK-QGYWLPSYKLKSSWATgLHLSVLFGHVECLLVLLDHNATINCR-PNGKTPLHVACEMANVDCVKILCDRGA 131
Cdd:PHA02875  14 ELDIARRLlDIGINPNFEIYDGISP-IKLAMKFRDSEAIKLLMKHGAIPDVKyPDIESELHDAVEEGDVKAVEELLDLGK 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706379   132 KLN-CYSLSGHTALHFCTTPSSILCAKQLVWRGANVNMktNNQDEETPLHTAAHFGlselvafyvehgaivdSVNAhmet 210
Cdd:PHA02875  93 FADdVFYKDGMTPLHLATILKKLDIMKLLIARGADPDI--PNTDKFSPLHLAVMMG----------------DIKG---- 150

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 7706379   211 plaiaaywalrfkeqeystehhlvCRMLLDYKAEVNARDDDFKSPLHKAAWNCDHVLMHMMLEAGAEANLMDINGCAAI 289
Cdd:PHA02875 151 ------------------------IELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANIDYFGKNGCVAA 205
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 157-316 2.06e-07

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 52.96  E-value: 2.06e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706379   157 KQLVWRGANVNMKTNNQDeETPLHTAAHFGLSELVAFYVEHGAIVDSVNAHMETPLaiaaYWALRFKEQEystehhlVCR 236
Cdd:PHA02878 151 KLLLSYGADINMKDRHKG-NTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPL----HHAVKHYNKP-------IVH 218

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706379   237 MLLDYKAEVNARDDDFKSPLHKAAWNC-DHVLMHMMLEAGAEANlmdingcaAIQYVLKVTSVRPAAQPEICYQLLLNHG 315
Cdd:PHA02878 219 ILLENGASTDARDKCGNTPLHISVGYCkDYDILKLLLEHGVDVN--------AKSYILGLTALHSSIKSERKLKLLLEYG 290


                 .
gi 7706379   316 A 316
Cdd:PHA02878 291 A 291
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 119-294 3.87e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 51.89  E-value: 3.87e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706379   119 NVDCVKILCDRGAKLNCYSLSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQDeeTPLHTAAHFGLSELVAFYVEHG 198
Cdd:PHA02874 103 EKDMIKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGC--YPIHIAIKHNFFDIIKLLLEKG 180

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706379   199 AIVDSVNAHMETPLAIAAYWAlrfkeqEYSTehhlvCRMLLDYKAEVNARDDDFKSPLHKAAWNCDHVLmhMMLEAGAEA 278
Cdd:PHA02874 181 AYANVKDNNGESPLHNAAEYG------DYAC-----IKLLIDHGNHIMNKCKNGFTPLHNAIIHNRSAI--ELLINNASI 247

                        170
                 ....*....|....*.
gi 7706379   279 NLMDINGCAAIQYVLK 294
Cdd:PHA02874 248 NDQDIDGSTPLHHAIN 263
Ank_2 pfam12796
Ankyrin repeats (3 copies);
179-282 5.99e-07

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 47.42  E-value: 5.99e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706379    179 LHTAAHFGLSELVAFYVEHGAIVDSVNAHMETPLAIAAywalrfkeqeySTEHHLVCRMLLDYkAEVNARDDDfKSPLHK 258
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAA-----------KNGHLEIVKLLLEH-ADVNLKDNG-RTALHY 67

                          90       100
                  ....*....|....*....|....
gi 7706379    259 AAWNCDHVLMHMMLEAGAEANLMD 282
Cdd:pfam12796  68 AARSGHLEIVKLLLEKGADINVKD 91
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 101-316 1.90e-06

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 49.88  E-value: 1.90e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706379   101 INCRPngKTPLHVACEMANVDCVKILCDRGAKLNCYSLSGHTALHFCTTPSSILCAKQLV-------------------- 160
Cdd:PHA02878  33 ASLIP--FIPLHQAVEARNLDVVKSLLTRGHNVNQPDHRDLTPLHIICKEPNKLGMKEMIrsinkcsvfytlvaikdafn 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706379   161 WRGANV------NMKTNNQD-EETPLHTAAHFGL--SELVAFYVEHGAIVDSVNAH-METPLAIAAywalrfkeqeySTE 230
Cdd:PHA02878 111 NRNVEIfkiiltNRYKNIQTiDLVYIDKKSKDDIieAEITKLLLSYGADINMKDRHkGNTALHYAT-----------ENK 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706379   231 HHLVCRMLLDYKAEVNARDDDFKSPLHKAAWNCDHVLMHMMLEAGAEANLMDINGCAAIQYvlkvtSVRPAAQPEIcYQL 310
Cdd:PHA02878 180 DQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHI-----SVGYCKDYDI-LKL 253


                 ....*.
gi 7706379   311 LLNHGA 316
Cdd:PHA02878 254 LLEHGV 259
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 177-294 3.23e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 49.19  E-value: 3.23e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706379   177 TPLHTAAHFGLSELVAFYVEHGAIVDSVNAHMETPLAIAaywaLRFKEQEY-----------------STEHHLVcRMLL 239
Cdd:PHA02874  37 TPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTA----IKIGAHDIikllidngvdtsilpipCIEKDMI-KTIL 111

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 7706379   240 DYKAEVNARDDDFKSPLHKAAWNCDHVLMHMMLEAGAEANLMDINGCAAIQYVLK 294
Cdd:PHA02874 112 DCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIK 166
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 109-377 4.17e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 48.81  E-value: 4.17e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706379   109 TPLHVACEMANVDCVKILCDRGAKLNcyslsghtalHFCTT-PSSILCAKQLvwrGANVNMK---TNNQDEET-PLHTAA 183
Cdd:PHA02874  37 TPLIDAIRSGDAKIVELFIKHGADIN----------HINTKiPHPLLTAIKI---GAHDIIKlliDNGVDTSIlPIPCIE 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706379   184 hfglSELVAFYVEHGAIVDSVNAHMETPLaiaaYWALRFKEQEystehhlVCRMLLDYKAEVNARDDDFKSPLHKAAWNC 263
Cdd:PHA02874 104 ----KDMIKTILDCGIDVNIKDAELKTFL----HYAIKKGDLE-------SIKMLFEYGADVNIEDDNGCYPIHIAIKHN 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706379   264 DHVLMHMMLEAGAEANLMDINGCAAIQYVLKVTSVRpaaqpeiCYQLLLNHGA------ARIYPPqFHKVIQACHScpkA 337
Cdd:PHA02874 169 FFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYA-------CIKLLIDHGNhimnkcKNGFTP-LHNAIIHNRS---A 237

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 7706379   338 IEVVVNayehirwntkwRRAIPDDDLEKYWDFYHSLFTVC 377
Cdd:PHA02874 238 IELLIN-----------NASINDQDIDGSTPLHHAINPPC 266
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 106-135 1.80e-05

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 41.42  E-value: 1.80e-05
                           10        20        30
                   ....*....|....*....|....*....|
gi 7706379     106 NGKTPLHVACEMANVDCVKILCDRGAKLNC 135
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
SOCS_box pfam07525
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more ...
 380-404 2.13e-05

SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.


Pssm-ID: 462192  Cd Length: 39  Bit Score: 41.38  E-value: 2.13e-05
                          10        20
                  ....*....|....*....|....*
gi 7706379    380 SPRTLMHLSRCAIRRTLHNRCHRAI 404
Cdd:pfam07525   1 TPRSLQHLCRLAIRRALGKRRLGAI 25
SOCS_ASB_like cd03716
SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB ...
 379-404 2.32e-05

SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB (SPRY domain-containing SOCS box proteins) protein families. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence of a variable number of repeats. SSB proteins contain a central SPRY domain and a C-terminal SOCS. Recently, it has been shown that all four SSB proteins interact with the MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF), and that SSB-1, SSB-2, and SSB-4 interact with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain.


Pssm-ID: 239686  Cd Length: 42  Bit Score: 41.33  E-value: 2.32e-05
                        10        20
                ....*....|....*....|....*.
gi 7706379  379 NSPRTLMHLSRCAIRRTLHNRCHRAI 404
Cdd:cd03716   1 STPRSLQHLCRLAIRRCLGRRRLELI 26
SOCS cd03587
SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region ...
 380-404 3.63e-05

SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins with a SOCS box), and WSBs (WD40 repeat-containing proteins with a SOCS box), as well as, other miscellaneous proteins. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239641  Cd Length: 41  Bit Score: 40.53  E-value: 3.63e-05
                        10        20
                ....*....|....*....|....*
gi 7706379  380 SPRTLMHLSRCAIRRTLHNRCHRAI 404
Cdd:cd03587   1 NPRSLQHLCRLAIRRCLGKRRLDLI 25
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 94-205 7.14e-05

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 44.66  E-value: 7.14e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706379    94 LLDHNATINCRPN-GKTPLHVACEMANVDCVKILCDRGAKLNCYSLSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNN 172
Cdd:PHA03100 178 LLSYGVPINIKDVyGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPSIKTIIET 257

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 7706379   173 --QDEETPLHT-----------AAHFGLSELvaFYVEHGAIVDSVN 205
Cdd:PHA03100 258 llYFKDKDLNTitkikmlkksiMYMFLLDPG--FYKNRKLIENSKS 301
Ank_4 pfam13637
Ankyrin repeats (many copies);
79-126 9.07e-05

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 39.95  E-value: 9.07e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 7706379     79 LHLSVLFGHVECLLVLLDHNATINCRP-NGKTPLHVACEMANVDCVKIL 126
Cdd:pfam13637   5 LHAAAASGHLELLRLLLEKGADINAVDgNGETALHFAASNGNVEVLKLL 53
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 107-207 1.40e-04

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 44.09  E-value: 1.40e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706379   107 GKTPLHVACEMANVDCVKILCDRGAKLNCYSLSGHTAL----------------HFCT-----TPSSILCA--------- 156
Cdd:PLN03192 558 GRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALwnaisakhhkifrilyHFASisdphAAGDLLCTaakrndlta 637

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 7706379   157 -KQLVWRGANVNmkTNNQDEETPLHTAAHFGLSELVAFYVEHGAIVDSVNAH 207
Cdd:PLN03192 638 mKELLKQGLNVD--SEDHQGATALQVAMAEDHVDMVRLLIMNGADVDKANTD 687
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 77-180 1.82e-04

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 43.85  E-value: 1.82e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706379   77 TGLHLSVLFGHVECLLVLLDH-----NATINCRP-NGKTPLHVACEMANVDCVKILCDRGAKLN-------CYSLSGHTA 143
Cdd:cd22192  53 TALHVAALYDNLEAAVVLMEAapelvNEPMTSDLyQGETALHIAVVNQNLNLVRELIARGADVVspratgtFFRPGPKNL 132

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 7706379  144 LHF---------CTTPSSILcaKQLVWRGANvnmkTNNQDE--ETPLH 180
Cdd:cd22192 133 IYYgehplsfaaCVGNEEIV--RLLIEHGAD----IRAQDSlgNTVLH 174
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 77-244 1.84e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 43.44  E-value: 1.84e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706379    77 TGLHLSVLFGHVECLLVLLDHNATINCRPNGK-TPLHVACEMANVDCVKILCDRGAKLNCYSLSGHTALHFCTTPSSILC 155
Cdd:PHA02875 104 TPLHLATILKKLDIMKLLIARGADPDIPNTDKfSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAI 183

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706379   156 AKQLVWRGANVNMKTNNQDeETPLHTAAHFGLSELVAFYVEHGA---IVDSVnahmetplaiaaywalrfkEQEYSTEHH 232
Cdd:PHA02875 184 CKMLLDSGANIDYFGKNGC-VAALCYAIENNKIDIVRLFIKRGAdcnIMFMI-------------------EGEECTILD 243

                        170
                 ....*....|..
gi 7706379   233 LVCRMLLDYKAE 244
Cdd:PHA02875 244 MICNMCTNLESE 255
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 82-316 2.19e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 43.44  E-value: 2.19e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706379    82 SVLFGHVECLLVLLDHNATINCR-PNGKTPLHVACEMANVDCVKILCDRGAKLNcyslsghtalhfcttpssilcakqlv 160
Cdd:PHA02875   9 AILFGELDIARRLLDIGINPNFEiYDGISPIKLAMKFRDSEAIKLLMKHGAIPD-------------------------- 62

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706379   161 wrganvnmkTNNQDEETPLHTAAHFGLSELVAFYVEHGAIVDSV-NAHMETPLaiaaYWALRFKEQEystehhlVCRMLL 239
Cdd:PHA02875  63 ---------VKYPDIESELHDAVEEGDVKAVEELLDLGKFADDVfYKDGMTPL----HLATILKKLD-------IMKLLI 122

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 7706379   240 DYKAEVNARDDDFKSPLHKAAWNCDHVLMHMMLEAGAEANLMDINGCAAIQYVLKVTSVrpaaqpEICyQLLLNHGA 316
Cdd:PHA02875 123 ARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDI------AIC-KMLLDSGA 192
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 106-135 2.86e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 38.04  E-value: 2.86e-04
                          10        20        30
                  ....*....|....*....|....*....|.
gi 7706379    106 NGKTPLHVACEMA-NVDCVKILCDRGAKLNC 135
Cdd:pfam00023   1 DGNTPLHLAAGRRgNLEIVKLLLSKGADVNA 31
Ank_5 pfam13857
Ankyrin repeats (many copies);
170-215 7.89e-04

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 37.33  E-value: 7.89e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 7706379    170 TNNQDEETPLHTAAHFGLSELVAFYVEHGAIVDSVNAHMETPLAIA 215
Cdd:pfam13857  11 RLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
PHA03095 PHA03095
ankyrin-like protein; Provisional
 157-316 8.61e-04

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 41.55  E-value: 8.61e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706379   157 KQLVWRGANVNMKTNNQDeeTPLHTAAHFGLS---ELVAFYVEHGAIVDSVNAHMETPLAIAAYWAlrfkeqeySTEHhl 233
Cdd:PHA03095  31 RRLLAAGADVNFRGEYGK--TPLHLYLHYSSEkvkDIVRLLLEAGADVNAPERCGFTPLHLYLYNA--------TTLD-- 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706379   234 VCRMLLDYKAEVNARDDDFKSPLHK--AAWNCDHVLMHMMLEAGAEANLMDINGCAAIQYVLKvtsvRPAAQPEICyQLL 311
Cdd:PHA03095  99 VIKLLIKAGADVNAKDKVGRTPLHVylSGFNINPKVIRLLLRKGADVNALDLYGMTPLAVLLK----SRNANVELL-RLL 173


                 ....*
gi 7706379   312 LNHGA 316
Cdd:PHA03095 174 IDAGA 178
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 106-135 8.86e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 36.47  E-value: 8.86e-04
                          10        20        30
                  ....*....|....*....|....*....|
gi 7706379    106 NGKTPLHVACEMANVDCVKILCDRGAKLNC 135
Cdd:pfam13606   1 DGNTPLHLAARNGRLEIVKLLLENGADINA 30
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 233-298 2.38e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 40.43  E-value: 2.38e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 7706379   233 LVCRMLLDYKAEVNARDDDFKSPLHKAAWNCDHVLMHMMLEAGAEANLMDINGCAAIQYVLKVTSV 298
Cdd:PHA02876 159 LIAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNI 224
TRPV cd21882
Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily ...
 69-159 3.02e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily (TRPV), named after the vanilloid receptor 1 (TRPV1), consists of six members: four thermo-sensing channels (TRPV1, TRPV2, TRPV3, and TRPV4) and two Ca2+ selective channels (TRPV5 and TRPV6). The calcium-selective channels TRPV5 and TRPV6 can be heterotetramers and are important for general Ca2+ homeostasis. All four channels within the TRPV1-4 group show temperature-invoked currents when expressed in heterologous cell systems, ranging from activation at ~25C for TRPV4 to ~52C for TRPV2. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains. The TRP family consists of membrane proteins that function as ion channels that communicate between the cell and its environment, by a vast array of physical or chemical stimuli, including radiation (in the form of temperature, infrared ,or light) and pressure (osmotic or mechanical). TRP channels are formed by a tetrameric complex of channel subunits. Based on sequence identity, the mammalian TRP channel family is classified into six subfamilies, with significant sequence similarity within the transmembrane domains, but very low similarity in their N- and C-terminal cytoplasmic regions. The six subfamilies are named based on their first member: TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPA (ankyrin), TRPML (mucolipin), and TRPP (polycystic).


Pssm-ID: 411975 [Multi-domain]  Cd Length: 600  Bit Score: 39.86  E-value: 3.02e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706379   69 YKLKSSWATGLHLSVLF---GHVECLLVLLDH-----------NATINCRP-NGKTPLHVACEMANVDCVKILCDRGAKL 133
Cdd:cd21882  20 YQRGATGKTCLHKAALNlndGVNEAIMLLLEAapdsgnpkelvNAPCTDEFyQGQTALHIAIENRNLNLVRLLVENGADV 99

                        90       100       110
                ....*....|....*....|....*....|...
gi 7706379  134 NC------YSLSGHTALHFCTTPSSI-LCAKQL 159
Cdd:cd21882 100 SAratgrfFRKSPGNLFYFGELPLSLaACTNQE 132
Ank_5 pfam13857
Ankyrin repeats (many copies);
92-147 3.43e-03

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 35.40  E-value: 3.43e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 7706379     92 LVLLDHNATINCRPNGKTPLHVACEMANVDCVKILCDRGAKLNCYSLSGHTALHFC 147
Cdd:pfam13857   1 LLEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 93-144 3.64e-03

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 39.50  E-value: 3.64e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 7706379    93 VLLDHNATINCRP-NGKTPLHVACEMANVDCVKILCDRGAKLNCYSLSGHTAL 144
Cdd:PTZ00322 100 ILLTGGADPNCRDyDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPL 152
TRPV cd21882
Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily ...
 107-206 6.41e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily (TRPV), named after the vanilloid receptor 1 (TRPV1), consists of six members: four thermo-sensing channels (TRPV1, TRPV2, TRPV3, and TRPV4) and two Ca2+ selective channels (TRPV5 and TRPV6). The calcium-selective channels TRPV5 and TRPV6 can be heterotetramers and are important for general Ca2+ homeostasis. All four channels within the TRPV1-4 group show temperature-invoked currents when expressed in heterologous cell systems, ranging from activation at ~25C for TRPV4 to ~52C for TRPV2. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains. The TRP family consists of membrane proteins that function as ion channels that communicate between the cell and its environment, by a vast array of physical or chemical stimuli, including radiation (in the form of temperature, infrared ,or light) and pressure (osmotic or mechanical). TRP channels are formed by a tetrameric complex of channel subunits. Based on sequence identity, the mammalian TRP channel family is classified into six subfamilies, with significant sequence similarity within the transmembrane domains, but very low similarity in their N- and C-terminal cytoplasmic regions. The six subfamilies are named based on their first member: TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPA (ankyrin), TRPML (mucolipin), and TRPP (polycystic).


Pssm-ID: 411975 [Multi-domain]  Cd Length: 600  Bit Score: 38.71  E-value: 6.41e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7706379  107 GKTPLHVAC---EMANVDCVKILCDRG-----------AKLNCYSLSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNN 172
Cdd:cd21882  26 GKTCLHKAAlnlNDGVNEAIMLLLEAApdsgnpkelvnAPCTDEFYQGQTALHIAIENRNLNLVRLLVENGADVSARATG 105

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 7706379  173 QD-----------EETPLHTAAHFGLSELVAFYVEHGAIVDSVNA 206
Cdd:cd21882 106 RFfrkspgnlfyfGELPLSLAACTNQEEIVRLLLENGAQPAALEA 150
Ank_4 pfam13637
Ankyrin repeats (many copies);
230-272 6.51e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 34.56  E-value: 6.51e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 7706379    230 EHHLVCRMLLDYKAEVNARDDDFKSPLHKAAWNCDHVLMHMML 272
Cdd:pfam13637  12 GHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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