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Conserved domains on  [gi|194294551|ref|NP_057073|]
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cysteine sulfinic acid decarboxylase isoform 1 [Homo sapiens]

Protein Classification

aspartate aminotransferase family protein( domain architecture ID 10157828)

aspartate aminotransferase family protein is a pyridoxal phosphate (PLP)-dependent enzyme similar to cysteine sulfinic acid decarboxylase that catalyzes the decarboxylation of L-aspartate, 3-sulfino-L-alanine (cysteine sulfinic acid), and L-cysteate to beta-alanine, hypotaurine, and taurine, respectively

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
DOPA_deC_like cd06450
DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent ...
116-516 7.16e-135

DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and glutamate decarboxylase (GDC). DDC is active as a dimer and catalyzes the decarboxylation of tyrosine. GDC catalyzes the decarboxylation of glutamate and HDC catalyzes the decarboxylation of histidine.


:

Pssm-ID: 99743 [Multi-domain]  Cd Length: 345  Bit Score: 394.26  E-value: 7.16e-135
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194294551 116 FFNQLFSGLDPHALAGRIITESLNTSQYTYEIAPVFVLMEEEVLRKLRALVGW--SSGDGIFCPGGSISNMYAVNLARYQ 193
Cdd:cd06450    1 FLAGFVTTMDPPALLLEMLTSAKNAIDFTWDESPAATEMEAEVVNWLAKLFGLpsEDADGVFTSGGSESNLLALLAARDR 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194294551 194 RYPDCKQRGLRTLPPLALFTSKECHYSIQKGAAFLGlgtDSVRVVKADERGKMVPEDLERQIGMAEAEGAVPFLVSATSG 273
Cdd:cd06450   81 ARKRLKAGGGRGIDKLVIVCSDQAHVSVEKAAAYLD---VKVRLVPVDEDGRMDPEALEAAIDEDKAEGLNPIMVVATAG 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194294551 274 TTVLGAFDPLEAIADVCQRHGLWLHVDAAWGGSVLLSQTHRHLLDGIQRADSVAWNPHKLLAAGLQCSALLLQdtsnllk 353
Cdd:cd06450  158 TTDTGAIDPLEEIADLAEKYDLWLHVDAAYGGFLLPFPEPRHLDFGIERVDSISVDPHKYGLVPLGCSAVLVR------- 230
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194294551 354 rchgsqasylfqqdkfydvaldtgdkvvqcgrrvdCLKLWLMWKAQGDQGLERRIDQAFVLARYLVEEMKKREGFELVME 433
Cdd:cd06450  231 -----------------------------------ALKLWATLRRFGRDGYGEHIDRIVDLAKYLAELIRADPGFELLGE 275
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194294551 434 PEFVNVCFWFVPPSlrgkqespdyheRLSKVAPVLKERMVKEGSMMIGYQPHGTRgNFFRVVVANSALTCADMDFLLNEL 513
Cdd:cd06450  276 PNLSLVCFRLKPSV------------KLDELNYDLSDRLNERGGWHVPATTLGGP-NVLRFVVTNPLTTRDDADALLEDI 342

                 ...
gi 194294551 514 ERL 516
Cdd:cd06450  343 ERA 345
 
Name Accession Description Interval E-value
DOPA_deC_like cd06450
DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent ...
116-516 7.16e-135

DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and glutamate decarboxylase (GDC). DDC is active as a dimer and catalyzes the decarboxylation of tyrosine. GDC catalyzes the decarboxylation of glutamate and HDC catalyzes the decarboxylation of histidine.


Pssm-ID: 99743 [Multi-domain]  Cd Length: 345  Bit Score: 394.26  E-value: 7.16e-135
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194294551 116 FFNQLFSGLDPHALAGRIITESLNTSQYTYEIAPVFVLMEEEVLRKLRALVGW--SSGDGIFCPGGSISNMYAVNLARYQ 193
Cdd:cd06450    1 FLAGFVTTMDPPALLLEMLTSAKNAIDFTWDESPAATEMEAEVVNWLAKLFGLpsEDADGVFTSGGSESNLLALLAARDR 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194294551 194 RYPDCKQRGLRTLPPLALFTSKECHYSIQKGAAFLGlgtDSVRVVKADERGKMVPEDLERQIGMAEAEGAVPFLVSATSG 273
Cdd:cd06450   81 ARKRLKAGGGRGIDKLVIVCSDQAHVSVEKAAAYLD---VKVRLVPVDEDGRMDPEALEAAIDEDKAEGLNPIMVVATAG 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194294551 274 TTVLGAFDPLEAIADVCQRHGLWLHVDAAWGGSVLLSQTHRHLLDGIQRADSVAWNPHKLLAAGLQCSALLLQdtsnllk 353
Cdd:cd06450  158 TTDTGAIDPLEEIADLAEKYDLWLHVDAAYGGFLLPFPEPRHLDFGIERVDSISVDPHKYGLVPLGCSAVLVR------- 230
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194294551 354 rchgsqasylfqqdkfydvaldtgdkvvqcgrrvdCLKLWLMWKAQGDQGLERRIDQAFVLARYLVEEMKKREGFELVME 433
Cdd:cd06450  231 -----------------------------------ALKLWATLRRFGRDGYGEHIDRIVDLAKYLAELIRADPGFELLGE 275
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194294551 434 PEFVNVCFWFVPPSlrgkqespdyheRLSKVAPVLKERMVKEGSMMIGYQPHGTRgNFFRVVVANSALTCADMDFLLNEL 513
Cdd:cd06450  276 PNLSLVCFRLKPSV------------KLDELNYDLSDRLNERGGWHVPATTLGGP-NVLRFVVTNPLTTRDDADALLEDI 342

                 ...
gi 194294551 514 ERL 516
Cdd:cd06450  343 ERA 345
GadA COG0076
Glutamate or tyrosine decarboxylase or a related PLP-dependent protein [Amino acid transport ...
48-519 1.11e-133

Glutamate or tyrosine decarboxylase or a related PLP-dependent protein [Amino acid transport and metabolism]; Glutamate or tyrosine decarboxylase or a related PLP-dependent protein is part of the Pathway/BioSystem: Pantothenate/CoA biosynthesis


Pssm-ID: 439846 [Multi-domain]  Cd Length: 460  Bit Score: 395.35  E-value: 1.11e-133
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194294551  48 LRAVFGVVVDEAIQKGTSVSQKVCEWkEPEELKQLLDLELRSQGESQKQILER-CRAVIRYSVKTGHPRFFNQLFSGLDP 126
Cdd:COG0076    2 FRALLHQALDLAADYLAGLDRPVFGP-SPEELRAALDEPLPEEGLPPEEALAElEDLVLPGSVDWNHPRFLAFVTGGTTP 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194294551 127 HALAGRIITESLNTSQYTYEIAPVFVLMEEEVLRKLRALVGWSSG-DGIFCPGGSISNMYAVNLARYQRYP-DCKQRGLR 204
Cdd:COG0076   81 AALAADLLASALNQNMGDWDTSPAATELEREVVRWLADLLGLPEGaGGVFTSGGTEANLLALLAARDRALArRVRAEGLP 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194294551 205 TLPPLALFTSKECHYSIQKGAAFLGLGTDSVRVVKADERGKMVPEDLERQIGMAEAEGAVPFLVSATSGTTVLGAFDPLE 284
Cdd:COG0076  161 GAPRPRIVVSEEAHSSVDKAARLLGLGRDALRKVPVDEDGRMDPDALEAAIDEDRAAGLNPIAVVATAGTTNTGAIDPLA 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194294551 285 AIADVCQRHGLWLHVDAAWGGSVLLSQTHRHLLDGIQRADSVAWNPHKLLAAGLQCSALLLQDTSnLLKRCHGSQASYLF 364
Cdd:COG0076  241 EIADIAREHGLWLHVDAAYGGFALPSPELRHLLDGIERADSITVDPHKWLYVPYGCGAVLVRDPE-LLREAFSFHASYLG 319
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194294551 365 QQDkfyDVALDTGDKVVQCGRRVDCLKLWLMWKAQGDQGLERRIDQAFVLARYLVEEMKKREGFELVMEPEFVNVCFWFV 444
Cdd:COG0076  320 PAD---DGVPNLGDYTLELSRRFRALKLWATLRALGREGYRELIERCIDLARYLAEGIAALPGFELLAPPELNIVCFRYK 396
                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 194294551 445 PPslrGKQESPDYHERLSkvapvlkERMVKEGSMMIGYQPHGTRgNFFRVVVANSALTCADMDFLLNELERLGQD 519
Cdd:COG0076  397 PA---GLDEEDALNYALR-------DRLRARGRAFLSPTKLDGR-VVLRLVVLNPRTTEDDVDALLDDLREAAAE 460
Pyridoxal_deC pfam00282
Pyridoxal-dependent decarboxylase conserved domain;
76-444 3.31e-121

Pyridoxal-dependent decarboxylase conserved domain;


Pssm-ID: 395219  Cd Length: 373  Bit Score: 360.58  E-value: 3.31e-121
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194294551   76 PEELKQLLDLELRSQGESQKQILERCRAVIRYSVKTGH-PRFFNQLFSGLDPHALAGRIITESLNTSQYTYEIAPVFVLM 154
Cdd:pfam00282   1 PGYLKPLLPLAAPIIPEPELQIDGDIRRNLMPGVTTWHsPHFHAYMPTGNSYPSLLGDMLTDAINCNGFTWESSPACTEL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194294551  155 EEEVLRKLRALVGWS------SGDGIFCPGGSISNMYAVNLARYQRYPDCKQRGLRTLPP-----LALFTSKECHYSIQK 223
Cdd:pfam00282  81 ENVVMNWLGEMLGLPaeflgqEGGGVLQPGSSESNLLALLAARTKWIKRMKAAGKPADSSgilakLVAYTSDQAHSSIEK 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194294551  224 GAAFLGLGtdsVRVVKADERGKMVPEDLERQIGMAEAEGAVPFLVSATSGTTVLGAFDPLEAIADVCQRHGLWLHVDAAW 303
Cdd:pfam00282 161 AALYGGVK---LREIPSDDNGKMRGMDLEKAIEEDKENGLIPFFVVATLGTTGSGAFDDLQELGDICAKHNLWLHVDAAY 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194294551  304 GGSVLLSQTHRHLLDGIQRADSVAWNPHKLLAAGLQCSALLLQDtSNLLKRCHGSQASYLFQQDKFYdvalDTGDKVVQC 383
Cdd:pfam00282 238 GGSAFICPEFRHWLFGIERADSITFNPHKWMLVLLDCSAVWVKD-KEALQQAFQFNPLYLGHTDSAY----DTGHKQIPL 312
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 194294551  384 GRRVDCLKLWLMWKAQGDQGLERRIDQAFVLARYLVEEMKKREGFELVMEPEFVNVCFWFV 444
Cdd:pfam00282 313 SRRFRILKLWFVIRSLGVEGLQNQIRRHVELAQYLEALIRKDGRFEICAEVGLGLVCFRLK 373
PLN02590 PLN02590
probable tyrosine decarboxylase
75-460 4.92e-41

probable tyrosine decarboxylase


Pssm-ID: 178200 [Multi-domain]  Cd Length: 539  Bit Score: 154.87  E-value: 4.92e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194294551  75 EPEELKQLLDLELRSQGESQKQILERCRAVIRYSVKTGH-PRFFNQLFSGLDPHALAGRIITESLNTSQYTYEIAPVFVL 153
Cdd:PLN02590  91 QPGYLRDMLPDSAPERPESLKELLDDVSKKIMPGITHWQsPSYFAYYASSTSVAGFLGEMLNAGLSVVGFTWLTSPAATE 170
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194294551 154 MEEEVLRKLRALVGW-----SSGDGifcpGGSISN-----MYAVNLARYQRYpdCKQRGLRTLPPLALFTSKECHYSIQK 223
Cdd:PLN02590 171 LEIIVLDWLAKLLQLpdhflSTGNG----GGVIQGtgceaVLVVVLAARDRI--LKKVGKTLLPQLVVYGSDQTHSSFRK 244
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194294551 224 GAAFLGLGTDSVRVVKADERGK--MVPEDLERQIGMAEAEGAVPFLVSATSGTTVLGAFDPLEAIADVCQRHGLWLHVDA 301
Cdd:PLN02590 245 ACLIGGIHEENIRLLKTDSSTNygMPPESLEEAISHDLAKGFIPFFICATVGTTSSAAVDPLVPLGNIAKKYGIWLHVDA 324
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194294551 302 AWGGSVLLSQTHRHLLDGIQRADSVAWNPHKLLAAGLQCSALLLQDTSNLLKRCHGSQASYLFQQDKfYDVALDTGDKVV 381
Cdd:PLN02590 325 AYAGNACICPEYRKFIDGIENADSFNMNAHKWLFANQTCSPLWVKDRYSLIDALKTNPEYLEFKVSK-KDTVVNYKDWQI 403
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 194294551 382 QCGRRVDCLKLWLMWKAQGDQGLERRIDQAFVLARYLVEEMKKREGFELVMEPEFVNVCFWFVPpsLRGKQESPDYHER 460
Cdd:PLN02590 404 SLSRRFRSLKLWMVLRLYGSENLRNFIRDHVNLAKHFEDYVAQDPSFEVVTTRYFSLVCFRLAP--VDGDEDQCNERNR 480
 
Name Accession Description Interval E-value
DOPA_deC_like cd06450
DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent ...
116-516 7.16e-135

DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and glutamate decarboxylase (GDC). DDC is active as a dimer and catalyzes the decarboxylation of tyrosine. GDC catalyzes the decarboxylation of glutamate and HDC catalyzes the decarboxylation of histidine.


Pssm-ID: 99743 [Multi-domain]  Cd Length: 345  Bit Score: 394.26  E-value: 7.16e-135
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194294551 116 FFNQLFSGLDPHALAGRIITESLNTSQYTYEIAPVFVLMEEEVLRKLRALVGW--SSGDGIFCPGGSISNMYAVNLARYQ 193
Cdd:cd06450    1 FLAGFVTTMDPPALLLEMLTSAKNAIDFTWDESPAATEMEAEVVNWLAKLFGLpsEDADGVFTSGGSESNLLALLAARDR 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194294551 194 RYPDCKQRGLRTLPPLALFTSKECHYSIQKGAAFLGlgtDSVRVVKADERGKMVPEDLERQIGMAEAEGAVPFLVSATSG 273
Cdd:cd06450   81 ARKRLKAGGGRGIDKLVIVCSDQAHVSVEKAAAYLD---VKVRLVPVDEDGRMDPEALEAAIDEDKAEGLNPIMVVATAG 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194294551 274 TTVLGAFDPLEAIADVCQRHGLWLHVDAAWGGSVLLSQTHRHLLDGIQRADSVAWNPHKLLAAGLQCSALLLQdtsnllk 353
Cdd:cd06450  158 TTDTGAIDPLEEIADLAEKYDLWLHVDAAYGGFLLPFPEPRHLDFGIERVDSISVDPHKYGLVPLGCSAVLVR------- 230
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194294551 354 rchgsqasylfqqdkfydvaldtgdkvvqcgrrvdCLKLWLMWKAQGDQGLERRIDQAFVLARYLVEEMKKREGFELVME 433
Cdd:cd06450  231 -----------------------------------ALKLWATLRRFGRDGYGEHIDRIVDLAKYLAELIRADPGFELLGE 275
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194294551 434 PEFVNVCFWFVPPSlrgkqespdyheRLSKVAPVLKERMVKEGSMMIGYQPHGTRgNFFRVVVANSALTCADMDFLLNEL 513
Cdd:cd06450  276 PNLSLVCFRLKPSV------------KLDELNYDLSDRLNERGGWHVPATTLGGP-NVLRFVVTNPLTTRDDADALLEDI 342

                 ...
gi 194294551 514 ERL 516
Cdd:cd06450  343 ERA 345
GadA COG0076
Glutamate or tyrosine decarboxylase or a related PLP-dependent protein [Amino acid transport ...
48-519 1.11e-133

Glutamate or tyrosine decarboxylase or a related PLP-dependent protein [Amino acid transport and metabolism]; Glutamate or tyrosine decarboxylase or a related PLP-dependent protein is part of the Pathway/BioSystem: Pantothenate/CoA biosynthesis


Pssm-ID: 439846 [Multi-domain]  Cd Length: 460  Bit Score: 395.35  E-value: 1.11e-133
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194294551  48 LRAVFGVVVDEAIQKGTSVSQKVCEWkEPEELKQLLDLELRSQGESQKQILER-CRAVIRYSVKTGHPRFFNQLFSGLDP 126
Cdd:COG0076    2 FRALLHQALDLAADYLAGLDRPVFGP-SPEELRAALDEPLPEEGLPPEEALAElEDLVLPGSVDWNHPRFLAFVTGGTTP 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194294551 127 HALAGRIITESLNTSQYTYEIAPVFVLMEEEVLRKLRALVGWSSG-DGIFCPGGSISNMYAVNLARYQRYP-DCKQRGLR 204
Cdd:COG0076   81 AALAADLLASALNQNMGDWDTSPAATELEREVVRWLADLLGLPEGaGGVFTSGGTEANLLALLAARDRALArRVRAEGLP 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194294551 205 TLPPLALFTSKECHYSIQKGAAFLGLGTDSVRVVKADERGKMVPEDLERQIGMAEAEGAVPFLVSATSGTTVLGAFDPLE 284
Cdd:COG0076  161 GAPRPRIVVSEEAHSSVDKAARLLGLGRDALRKVPVDEDGRMDPDALEAAIDEDRAAGLNPIAVVATAGTTNTGAIDPLA 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194294551 285 AIADVCQRHGLWLHVDAAWGGSVLLSQTHRHLLDGIQRADSVAWNPHKLLAAGLQCSALLLQDTSnLLKRCHGSQASYLF 364
Cdd:COG0076  241 EIADIAREHGLWLHVDAAYGGFALPSPELRHLLDGIERADSITVDPHKWLYVPYGCGAVLVRDPE-LLREAFSFHASYLG 319
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194294551 365 QQDkfyDVALDTGDKVVQCGRRVDCLKLWLMWKAQGDQGLERRIDQAFVLARYLVEEMKKREGFELVMEPEFVNVCFWFV 444
Cdd:COG0076  320 PAD---DGVPNLGDYTLELSRRFRALKLWATLRALGREGYRELIERCIDLARYLAEGIAALPGFELLAPPELNIVCFRYK 396
                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 194294551 445 PPslrGKQESPDYHERLSkvapvlkERMVKEGSMMIGYQPHGTRgNFFRVVVANSALTCADMDFLLNELERLGQD 519
Cdd:COG0076  397 PA---GLDEEDALNYALR-------DRLRARGRAFLSPTKLDGR-VVLRLVVLNPRTTEDDVDALLDDLREAAAE 460
Pyridoxal_deC pfam00282
Pyridoxal-dependent decarboxylase conserved domain;
76-444 3.31e-121

Pyridoxal-dependent decarboxylase conserved domain;


Pssm-ID: 395219  Cd Length: 373  Bit Score: 360.58  E-value: 3.31e-121
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194294551   76 PEELKQLLDLELRSQGESQKQILERCRAVIRYSVKTGH-PRFFNQLFSGLDPHALAGRIITESLNTSQYTYEIAPVFVLM 154
Cdd:pfam00282   1 PGYLKPLLPLAAPIIPEPELQIDGDIRRNLMPGVTTWHsPHFHAYMPTGNSYPSLLGDMLTDAINCNGFTWESSPACTEL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194294551  155 EEEVLRKLRALVGWS------SGDGIFCPGGSISNMYAVNLARYQRYPDCKQRGLRTLPP-----LALFTSKECHYSIQK 223
Cdd:pfam00282  81 ENVVMNWLGEMLGLPaeflgqEGGGVLQPGSSESNLLALLAARTKWIKRMKAAGKPADSSgilakLVAYTSDQAHSSIEK 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194294551  224 GAAFLGLGtdsVRVVKADERGKMVPEDLERQIGMAEAEGAVPFLVSATSGTTVLGAFDPLEAIADVCQRHGLWLHVDAAW 303
Cdd:pfam00282 161 AALYGGVK---LREIPSDDNGKMRGMDLEKAIEEDKENGLIPFFVVATLGTTGSGAFDDLQELGDICAKHNLWLHVDAAY 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194294551  304 GGSVLLSQTHRHLLDGIQRADSVAWNPHKLLAAGLQCSALLLQDtSNLLKRCHGSQASYLFQQDKFYdvalDTGDKVVQC 383
Cdd:pfam00282 238 GGSAFICPEFRHWLFGIERADSITFNPHKWMLVLLDCSAVWVKD-KEALQQAFQFNPLYLGHTDSAY----DTGHKQIPL 312
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 194294551  384 GRRVDCLKLWLMWKAQGDQGLERRIDQAFVLARYLVEEMKKREGFELVMEPEFVNVCFWFV 444
Cdd:pfam00282 313 SRRFRILKLWFVIRSLGVEGLQNQIRRHVELAQYLEALIRKDGRFEICAEVGLGLVCFRLK 373
PLN02590 PLN02590
probable tyrosine decarboxylase
75-460 4.92e-41

probable tyrosine decarboxylase


Pssm-ID: 178200 [Multi-domain]  Cd Length: 539  Bit Score: 154.87  E-value: 4.92e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194294551  75 EPEELKQLLDLELRSQGESQKQILERCRAVIRYSVKTGH-PRFFNQLFSGLDPHALAGRIITESLNTSQYTYEIAPVFVL 153
Cdd:PLN02590  91 QPGYLRDMLPDSAPERPESLKELLDDVSKKIMPGITHWQsPSYFAYYASSTSVAGFLGEMLNAGLSVVGFTWLTSPAATE 170
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194294551 154 MEEEVLRKLRALVGW-----SSGDGifcpGGSISN-----MYAVNLARYQRYpdCKQRGLRTLPPLALFTSKECHYSIQK 223
Cdd:PLN02590 171 LEIIVLDWLAKLLQLpdhflSTGNG----GGVIQGtgceaVLVVVLAARDRI--LKKVGKTLLPQLVVYGSDQTHSSFRK 244
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194294551 224 GAAFLGLGTDSVRVVKADERGK--MVPEDLERQIGMAEAEGAVPFLVSATSGTTVLGAFDPLEAIADVCQRHGLWLHVDA 301
Cdd:PLN02590 245 ACLIGGIHEENIRLLKTDSSTNygMPPESLEEAISHDLAKGFIPFFICATVGTTSSAAVDPLVPLGNIAKKYGIWLHVDA 324
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194294551 302 AWGGSVLLSQTHRHLLDGIQRADSVAWNPHKLLAAGLQCSALLLQDTSNLLKRCHGSQASYLFQQDKfYDVALDTGDKVV 381
Cdd:PLN02590 325 AYAGNACICPEYRKFIDGIENADSFNMNAHKWLFANQTCSPLWVKDRYSLIDALKTNPEYLEFKVSK-KDTVVNYKDWQI 403
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 194294551 382 QCGRRVDCLKLWLMWKAQGDQGLERRIDQAFVLARYLVEEMKKREGFELVMEPEFVNVCFWFVPpsLRGKQESPDYHER 460
Cdd:PLN02590 404 SLSRRFRSLKLWMVLRLYGSENLRNFIRDHVNLAKHFEDYVAQDPSFEVVTTRYFSLVCFRLAP--VDGDEDQCNERNR 480
PLN02880 PLN02880
tyrosine decarboxylase
75-447 7.61e-40

tyrosine decarboxylase


Pssm-ID: 215475 [Multi-domain]  Cd Length: 490  Bit Score: 150.83  E-value: 7.61e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194294551  75 EPEELKQLLDLELRSQGESQKQILERCRAVIRYSVKTGH-PRFFNQLFSGLDPHALAGRIITESLNTSQYTYEIAPVFVL 153
Cdd:PLN02880  43 QPGYLRELLPDSAPNQPETLDQVLDDVQAKILPGVTHWQsPNYFAYYPSNSSVAGFLGEMLSAGLNIVGFSWITSPAATE 122
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194294551 154 MEEEVLRKLRALVG-----WSSGDGIFCPGGSISNMYAVNLARyQRYPDCKQRGLRTLPPLALFTSKECHYSIQKGAAFL 228
Cdd:PLN02880 123 LEMIVLDWLAKLLNlpeqfLSTGNGGGVIQGTASEAVLVVLLA-ARDRVLRKVGKNALEKLVVYASDQTHSALQKACQIA 201
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194294551 229 GLGTDSVRVVKADERGK--MVPEDLERQIGMAEAEGAVPFLVSATSGTTVLGAFDPLEAIADVCQRHGLWLHVDAAWGGS 306
Cdd:PLN02880 202 GIHPENCRLLKTDSSTNyaLAPELLSEAISTDLSSGLIPFFLCATVGTTSSTAVDPLLELGKIAKSNGMWFHVDAAYAGS 281
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194294551 307 VLLSQTHRHLLDGIQRADSVAWNPHKLLAAGLQCSALLLQDTSNLLKRChGSQASYLFQQDKFYDVALDTGDKVVQCGRR 386
Cdd:PLN02880 282 ACICPEYRHYIDGVEEADSFNMNAHKWFLTNFDCSLLWVKDRNALIQSL-STNPEFLKNKASQANSVVDYKDWQIPLGRR 360
                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 194294551 387 VDCLKLWLMWKAQGDQGLERRIDQAFVLARYLVEEMKKREGFELVMEPEFVNVCFWFVPPS 447
Cdd:PLN02880 361 FRSLKLWMVLRLYGVENLQSYIRNHIKLAKEFEQLVAQDSRFEVVTPRIFSLVCFRLVPPK 421
PRK02769 PRK02769
histidine decarboxylase; Provisional
178-426 3.33e-16

histidine decarboxylase; Provisional


Pssm-ID: 235068 [Multi-domain]  Cd Length: 380  Bit Score: 80.47  E-value: 3.33e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194294551 178 GGSISNMYAVNLARyQRYPDCkqrglrtlpplALFTSKECHYSIQKGAAFLGLGTdsvRVVKADERGKMVPEDLERQIgm 257
Cdd:PRK02769  92 GGTEGNLYGCYLAR-ELFPDG-----------TLYYSKDTHYSVSKIARLLRIKS---RVITSLPNGEIDYDDLISKI-- 154
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194294551 258 aEAEGAVPFLVSATSGTTVLGAFDPLEAIADVCQRHGL---WLHVDAAWGGSVLLSQTHRHLLDGIQRADSVAWNPHKLL 334
Cdd:PRK02769 155 -KENKNQPPIIFANIGTTMTGAIDNIKEIQEILKKIGIddyYIHADAALSGMILPFVNNPPPFSFADGIDSIAISGHKFI 233
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194294551 335 AAGLQCSALllqdtsnLLKRCHGSQASylfqqdkfYDVA-LDTGDKVVQCGRR-VDCLKLWLMWKAQGDQGLERRIDQAF 412
Cdd:PRK02769 234 GSPMPCGIV-------LAKKKYVERIS--------VDVDyIGSRDQTISGSRNgHTALLLWAAIRSLGSKGLRQRVQHCL 298
                        250
                 ....*....|....
gi 194294551 413 VLARYLVEEMKKRE 426
Cdd:PRK02769 299 DMAQYAVDRLQANG 312
AAT_I cd01494
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP) ...
155-336 2.53e-08

Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. Structure and sequence analysis has revealed that the PLP dependent enzymes can be classified into four major groups of different evolutionary origin: aspartate aminotransferase superfamily (fold type I), tryptophan synthase beta superfamily (fold type II), alanine racemase superfamily (fold type III), and D-amino acid superfamily (fold type IV) and Glycogen phophorylase family (fold type V).


Pssm-ID: 99742 [Multi-domain]  Cd Length: 170  Bit Score: 53.54  E-value: 2.53e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194294551 155 EEEVLRKLRALVGWSSGDGIFCPGGSISN-MYAVNLARYQRYpdckqrglrtlpplALFTSKECHYSIQKGAAFLGLGTD 233
Cdd:cd01494    2 LEELEEKLARLLQPGNDKAVFVPSGTGANeAALLALLGPGDE--------------VIVDANGHGSRYWVAAELAGAKPV 67
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194294551 234 SVRVVKADERGKMVPEDLERQIGmaeaegAVPFLVSATSGTTVLGAFDPLEAIADVCQRHGLWLHVDAAWGGsvlLSQTH 313
Cdd:cd01494   68 PVPVDDAGYGGLDVAILEELKAK------PNVALIVITPNTTSGGVLVPLKEIRKIAKEYGILLLVDAASAG---GASPA 138
                        170       180
                 ....*....|....*....|...
gi 194294551 314 RHLLDGIQRADSVAWNPHKLLAA 336
Cdd:cd01494  139 PGVLIPEGGADVVTFSLHKNLGG 161
Aminotran_5 pfam00266
Aminotransferase class-V; This domain is found in amino transferases, and other enzymes ...
156-335 2.89e-08

Aminotransferase class-V; This domain is found in amino transferases, and other enzymes including cysteine desulphurase EC:4.4.1.-.


Pssm-ID: 425567 [Multi-domain]  Cd Length: 368  Bit Score: 55.72  E-value: 2.89e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194294551  156 EEVLRKLRALVGWSSGDGI-FCPGGSIS-NMYAVNLARYQRYPDCkqrglrtlpplALFTSKEcHYSI----QKGAAFLG 229
Cdd:pfam00266  46 EEAREKVAEFINAPSNDEIiFTSGTTEAiNLVALSLGRSLKPGDE-----------IVITEME-HHANlvpwQELAKRTG 113
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194294551  230 LgtdSVRVVKADERGKMVPEDLERQIgmaeAEGAVpfLVSATSGTTVLGAFDPLEAIADVCQRHGLWLHVDAAwggsvll 309
Cdd:pfam00266 114 A---RVRVLPLDEDGLLDLDELEKLI----TPKTK--LVAITHVSNVTGTIQPVPEIGKLAHQYGALVLVDAA------- 177
                         170       180       190
                  ....*....|....*....|....*....|
gi 194294551  310 sQT--HRHlLDgIQR--ADSVAWNPHKLLA 335
Cdd:pfam00266 178 -QAigHRP-ID-VQKlgVDFLAFSGHKLYG 204
GLY1 COG2008
Threonine aldolase [Amino acid transport and metabolism];
156-303 1.27e-07

Threonine aldolase [Amino acid transport and metabolism];


Pssm-ID: 441611 [Multi-domain]  Cd Length: 333  Bit Score: 53.53  E-value: 1.27e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194294551 156 EEVLRKLRALVGwsSGDGIFCPGGSISNMYAVN--LARYQrypdckqrglrtlpplALFTSKECHysIQK----GAAFL- 228
Cdd:COG2008   38 NRLEERVAELFG--KEAALFVPSGTMANQLALRahTRPGD----------------EVICHETAH--IYVdeggAPEALs 97
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 194294551 229 GLgtdSVRVVkADERGKMVPEDLERQIGMAEAEGAVPFLVS---ATSGTTVLgAFDPLEAIADVCQRHGLWLHVDAAW 303
Cdd:COG2008   98 GV---KLLPV-PGEDGKLTPEDLEAAIRPGDVHFPQPGLVSlenTTEGGTVY-PLEELRAIAAVAREHGLPLHLDGAR 170
LdcC COG1982
Arginine/lysine/ornithine decarboxylase [Amino acid transport and metabolism];
283-438 1.48e-06

Arginine/lysine/ornithine decarboxylase [Amino acid transport and metabolism];


Pssm-ID: 441585 [Multi-domain]  Cd Length: 486  Bit Score: 50.88  E-value: 1.48e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194294551 283 LEAIADVCQRHGLWLHVDAAWGGsvllsqtHRHLLDGIQR------ADSVAWNPHKLLAAGLQCSALLLQDT---SNLLK 353
Cdd:COG1982  179 LKAIAELAHEHGIPVLVDEAHGA-------HFGFHPDLPRsameagADLVVQSTHKTLGALTQSSMLHVKGGrvdHERVN 251
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194294551 354 RC---HGS-QASYLFqqdkfydVA-LDTgdkvvqcGRRvdclklwlMWKAQGdqglERRIDQAFVLARYLVEEMKKREGF 428
Cdd:COG1982  252 EAlmlLQStSPSYLL-------MAsLDV-------ARR--------QMAGEG----EELLDEALELAIEARKEINKIPGL 305
                        170
                 ....*....|
gi 194294551 429 ElVMEPEFVN 438
Cdd:COG1982  306 Y-VFGPEDLG 314
CsdA COG0520
Selenocysteine lyase/Cysteine desulfurase [Amino acid transport and metabolism];
235-335 1.02e-05

Selenocysteine lyase/Cysteine desulfurase [Amino acid transport and metabolism];


Pssm-ID: 440286 [Multi-domain]  Cd Length: 396  Bit Score: 47.83  E-value: 1.02e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194294551 235 VRVVKADERGKMVPEDLERQIGmaeaEGAVpfLVSATSGTTVLGAFDPLEAIADVCQRHGLWLHVDAAwggsvllsQT-- 312
Cdd:COG0520  131 VRVIPLDEDGELDLEALEALLT----PRTK--LVAVTHVSNVTGTVNPVKEIAALAHAHGALVLVDGA--------QSvp 196
                         90       100
                 ....*....|....*....|....*..
gi 194294551 313 HRHL----LDgiqrADSVAWNPHKLLA 335
Cdd:COG0520  197 HLPVdvqaLG----CDFYAFSGHKLYG 219
TA_like cd06502
Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP) ...
155-302 1.52e-05

Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a secondary glycine biosynthetic pathway.


Pssm-ID: 99748 [Multi-domain]  Cd Length: 338  Bit Score: 46.94  E-value: 1.52e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194294551 155 EEEVLRKLRALVGWSSGD--GIFCPGGSISNmyavnlaryqrypdckQRGLRTL--PPLALFTSKECHYSI--QKGAAFL 228
Cdd:cd06502   30 EDPTTAKLEARAAELFGKeaALFVPSGTAAN----------------QLALAAHtqPGGSVICHETAHIYTdeAGAPEFL 93
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 194294551 229 GlgtdSVRVVKAD-ERGKMVPEDLERQI-GMAEAEGAVPFLVSATSgTTVLGAFDPLE---AIADVCQRHGLWLHVDAA 302
Cdd:cd06502   94 S----GVKLLPVPgENGKLTPEDLEAAIrPRDDIHFPPPSLVSLEN-TTEGGTVYPLDelkAISALAKENGLPLHLDGA 167
PLN03032 PLN03032
serine decarboxylase; Provisional
202-344 5.54e-05

serine decarboxylase; Provisional


Pssm-ID: 166673 [Multi-domain]  Cd Length: 374  Bit Score: 45.59  E-value: 5.54e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194294551 202 GLRTLPPLALFTSKECHYSIQKGAAFLGLGTDSVRVVkadERGKMVPEDLERQIgmAEAEGAvPFLVSATSGTTVLGAFD 281
Cdd:PLN03032 105 GREVFPDGILYASRESHYSVFKAARMYRMEAVKVPTL---PSGEIDYDDLERAL--AKNRDK-PAILNVNIGTTVKGAVD 178
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 194294551 282 PLEAIADVCQRHG-----LWLHVDAAWGGSVLLSQTHRHLLDGIQRADSVAWNPHKLLAAGLQCSALL 344
Cdd:PLN03032 179 DLDRILRILKELGytedrFYIHCDGALFGLMMPFVSRAPEVTFRKPIGSVSVSGHKFLGCPMPCGVAL 246
PLN02721 PLN02721
threonine aldolase
173-326 1.37e-04

threonine aldolase


Pssm-ID: 178323 [Multi-domain]  Cd Length: 353  Bit Score: 44.29  E-value: 1.37e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194294551 173 GIFCPGGSISNMYAVNLaryqrypDCKQRGLRtlpplaLFTSKECHYSIQKGAAFLGLGTDSVRVVKADERGKMVPEDLE 252
Cdd:PLN02721  58 ALFVPSGTMGNLISVLV-------HCDVRGSE------VILGDNSHIHLYENGGISTLGGVHPRTVKNNEDGTMDLDAIE 124
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194294551 253 RQI-GMAEAEGAVPFLV-----SATSGttvlGAFDPLE---AIADVCQRHGLWLHVDAA--WGGSVLLSQTHRHLLdgiQ 321
Cdd:PLN02721 125 AAIrPKGDDHFPTTRLIclentHANCG----GRCLSVEytdKVGELAKRHGLKLHIDGAriFNASVALGVPVHRLV---K 197

                 ....*
gi 194294551 322 RADSV 326
Cdd:PLN02721 198 AADSV 202
Beta_elim_lyase pfam01212
Beta-eliminating lyase;
145-302 4.80e-04

Beta-eliminating lyase;


Pssm-ID: 426128 [Multi-domain]  Cd Length: 288  Bit Score: 42.20  E-value: 4.80e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194294551  145 YEIAPVFVLMEEEVlrklRALVGWSSGdgIFCPGGSISNmyavnlaryqrypdckQRGLRTL--PPLALFTSKECHYSI- 221
Cdd:pfam01212  28 YGGDPTVNRLEDRV----AELFGKEAA--LFVPSGTAAN----------------QLALMAHcqRGDEVICGEPAHIHFd 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194294551  222 -QKGAAFLGLGTdsVRVVKADERGKMVPEDLERQI-GMAEAEGAVPFLVSAT-----SGTTVLgAFDPLEAIADVCQRHG 294
Cdd:pfam01212  86 eTGGHAELGGVQ--PRPLDGDEAGNMDLEDLEAAIrEVGADIFPPTGLISLEnthnsAGGQVV-SLENLREIAALAREHG 162

                  ....*...
gi 194294551  295 LWLHVDAA 302
Cdd:pfam01212 163 IPVHLDGA 170
SufS_like cd06453
Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP) ...
234-302 5.98e-04

Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine; and selenocysteine lyase catalyzes the decomposition of L-selenocysteine.


Pssm-ID: 99746 [Multi-domain]  Cd Length: 373  Bit Score: 42.07  E-value: 5.98e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 194294551 234 SVRVVKADERGKMVPEDLERQIGMAEAegavpfLVSATSGTTVLGAFDPLEAIADVCQRHGLWLHVDAA 302
Cdd:cd06453  115 KLKVVPVDDDGQLDLEALEKLLTERTK------LVAVTHVSNVLGTINPVKEIGEIAHEAGVPVLVDGA 177
Orn_deC_like cd00615
Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent ...
283-365 1.26e-03

Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine decarboxylase (LDC). ODC is a dodecamer composed of six homodimers and catalyzes the decarboxylation of tryptophan. ADC catalyzes the decarboxylation of arginine and LDC catalyzes the decarboxylation of lysine. Members of this family are widely found in all three forms of life.


Pssm-ID: 99739 [Multi-domain]  Cd Length: 294  Bit Score: 40.69  E-value: 1.26e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194294551 283 LEAIADVCQRHGLWLHVDAAWGGsvllsqtHRHLLDGIQR------ADSVAWNPHKLLAAGLQCSALLLQDtsNLLKRCH 356
Cdd:cd00615  172 LRKIVEEAHHRGLPVLVDEAHGA-------HFRFHPILPSsaamagADIVVQSTHKTLPALTQGSMIHVKG--DLVNPDR 242

                 ....*....
gi 194294551 357 GSQASYLFQ 365
Cdd:cd00615  243 VNEALNLHQ 251
NifS COG1104
Cysteine desulfurase/Cysteine sulfinate desulfinase IscS or related enzyme, NifS family [Amino ...
156-302 2.33e-03

Cysteine desulfurase/Cysteine sulfinate desulfinase IscS or related enzyme, NifS family [Amino acid transport and metabolism];


Pssm-ID: 440721 [Multi-domain]  Cd Length: 381  Bit Score: 40.42  E-value: 2.33e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194294551 156 EEVLRKLRALVGWSSGDGIFCPGGSISNmyavNLA---RYQRYPDCKQRglrtlpplaLFTSK-EcHYSIQKGAAFL-GL 230
Cdd:COG1104   48 EEAREQVAALLGADPEEIIFTSGGTEAN----NLAikgAARAYRKKGKH---------IITSAiE-HPAVLETARFLeKE 113
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 194294551 231 GTDsVRVVKADERGKMVPEDLERQIgmaeAEGAVpfLVSATSGTTVLGAFDPLEAIADVCQRHGLWLHVDAA 302
Cdd:COG1104  114 GFE-VTYLPVDEDGRVDLEALEAAL----RPDTA--LVSVMHANNETGTIQPIAEIAEIAKEHGVLFHTDAV 178
PLN02263 PLN02263
serine decarboxylase
202-305 2.76e-03

serine decarboxylase


Pssm-ID: 177904 [Multi-domain]  Cd Length: 470  Bit Score: 40.18  E-value: 2.76e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194294551 202 GLRTLPPLALFTSKECHYSIQKGAAFLglgtdSVRVVKAD--ERGKMVPEDLERQIgMAEAEGavPFLVSATSGTTVLGA 279
Cdd:PLN02263 172 GREVFPDGILYASRESHYSVFKAARMY-----RMECVKVDtlVSGEIDCADFKAKL-LANKDK--PAIINVNIGTTVKGA 243
                         90       100       110
                 ....*....|....*....|....*....|.
gi 194294551 280 FDPLEAIADVCQRHG-----LWLHVDAAWGG 305
Cdd:PLN02263 244 VDDLDLVIKTLEECGfsqdrFYIHCDGALFG 274
KBL_like cd06454
KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate ...
248-302 3.67e-03

KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS), 8-amino-7-oxononanoate synthase (AONS), and 2-amino-3-ketobutyrate CoA ligase (KBL). SPT is responsible for the condensation of L-serine with palmitoyl-CoA to produce 3-ketodihydrospingosine, the reaction of the first step in sphingolipid biosynthesis. ALAS is involved in heme biosynthesis; it catalyzes the synthesis of 5-aminolevulinic acid from glycine and succinyl-coenzyme A. AONS catalyses the decarboxylative condensation of l-alanine and pimeloyl-CoA in the first committed step of biotin biosynthesis. KBL catalyzes the second reaction step of the metabolic degradation pathway for threonine converting 2-amino-3-ketobutyrate, to glycine and acetyl-CoA. The members of this CD are widely found in all three forms of life.


Pssm-ID: 99747 [Multi-domain]  Cd Length: 349  Bit Score: 39.47  E-value: 3.67e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 194294551 248 PEDLERQIgmAEA-EGAVPFLVSATSGTTVLGAFDPLEAIADVCQRHGLWLHVDAA 302
Cdd:cd06454  117 MEDLEKLL--REArRPYGKKLIVTEGVYSMDGDIAPLPELVDLAKKYGAILFVDEA 170
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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