NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|588282768|ref|NP_056468|]
View 

RIB43A-like with coiled-coils protein 2 [Homo sapiens]

Protein Classification

RIB43A domain-containing protein( domain architecture ID 12067327)

RIB43A domain-containing protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
RIB43A pfam05914
RIB43A; This family consists of several RIB43A-like eukaryotic proteins. Ciliary and flagellar ...
13-382 4.41e-162

RIB43A; This family consists of several RIB43A-like eukaryotic proteins. Ciliary and flagellar microtubules contain a specialized set of protofilaments, termed ribbons, that are composed of tubulin and several associated proteins. RIB43A was first characterized in the unicellular biflagellate, Chlamydomonas reinhardtii although highly related sequences are present in several higher eukaryotes including humans. The function of this protein is unknown although the structure of RIB43A and its association with the specialized protofilament ribbons and with basal bodies is relevant to the proposed role of ribbons in forming and stabilising doublet and triplet microtubules and in organizing their three-dimensional structure. Human RIB43A homologs could represent a structural requirement in centriole replication in dividing cells.


:

Pssm-ID: 461780 [Multi-domain]  Cd Length: 372  Bit Score: 458.98  E-value: 4.41e-162
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 588282768   13 DLRQDANLAKRRHAELCRQKRVFNARNRIIGGDTEAWDVQVHDQKIKEATEKARHETFAAEMRQNDKIMCILENRKKRDR 92
Cdd:pfam05914   2 DLKEAAAIERRRQREEERKSRIFNARNRTIGVDVEALDKQVEEKKRQEAAEKAREEAFAEEMVQNDKIALMLEKREEEDR 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 588282768   93 KNLCRAINDFQQSFQKPETRREFDLSDPLALKKDLPARQSDNDVRNTISGMQKFMGEDLNFHERKKFQEEQNREWSLQQQ 172
Cdd:pfam05914  82 RRLNKELNEFRQQHQRPETRREFDLNDPDALKKDLPARVSDDDPRCGPSSMQKFEGEDLNREERKKLQQEQMREWLEQQI 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 588282768  173 REWKNARAEQKCAEALYTETRLQFDETAKHLQKLESTTRKAVCASVKDFNKSQAIESVERKKQEKKQEQEDNLAEITNLL 252
Cdd:pfam05914 162 EEKKQAEEEEKHAELLYDQKRLERDRRALELAKLEEECRRAVNAATKNFNQALAAEQAERRRLEKRQEQEDNLAEIYNHL 241
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 588282768  253 RGDLLSENPQQAASSFGPHRVVPDRWKGMTQEQLEQIRLVQKQQIQEKLRLQEEKRQRDLDWDRRRIQGARATLLFERQQ 332
Cdd:pfam05914 242 TSDLLTENPEVAQSSLGPHRVIPDRWKGMSPEQLKEIRKEQEQQREEKERRREEEKQRDAEWDRQRLELARAALLLEREQ 321
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|.
gi 588282768  333 WRRQRDLRRALDSSNLSLAKEQHLQKKYMN-EVYTNQPTGDYFTQFNTGSR 382
Cdd:pfam05914 322 QRLRRELRRQLDEENLQLAQEQKARQEYLNkEVYTNKPTADYFDQFNTSSR 372
 
Name Accession Description Interval E-value
RIB43A pfam05914
RIB43A; This family consists of several RIB43A-like eukaryotic proteins. Ciliary and flagellar ...
13-382 4.41e-162

RIB43A; This family consists of several RIB43A-like eukaryotic proteins. Ciliary and flagellar microtubules contain a specialized set of protofilaments, termed ribbons, that are composed of tubulin and several associated proteins. RIB43A was first characterized in the unicellular biflagellate, Chlamydomonas reinhardtii although highly related sequences are present in several higher eukaryotes including humans. The function of this protein is unknown although the structure of RIB43A and its association with the specialized protofilament ribbons and with basal bodies is relevant to the proposed role of ribbons in forming and stabilising doublet and triplet microtubules and in organizing their three-dimensional structure. Human RIB43A homologs could represent a structural requirement in centriole replication in dividing cells.


Pssm-ID: 461780 [Multi-domain]  Cd Length: 372  Bit Score: 458.98  E-value: 4.41e-162
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 588282768   13 DLRQDANLAKRRHAELCRQKRVFNARNRIIGGDTEAWDVQVHDQKIKEATEKARHETFAAEMRQNDKIMCILENRKKRDR 92
Cdd:pfam05914   2 DLKEAAAIERRRQREEERKSRIFNARNRTIGVDVEALDKQVEEKKRQEAAEKAREEAFAEEMVQNDKIALMLEKREEEDR 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 588282768   93 KNLCRAINDFQQSFQKPETRREFDLSDPLALKKDLPARQSDNDVRNTISGMQKFMGEDLNFHERKKFQEEQNREWSLQQQ 172
Cdd:pfam05914  82 RRLNKELNEFRQQHQRPETRREFDLNDPDALKKDLPARVSDDDPRCGPSSMQKFEGEDLNREERKKLQQEQMREWLEQQI 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 588282768  173 REWKNARAEQKCAEALYTETRLQFDETAKHLQKLESTTRKAVCASVKDFNKSQAIESVERKKQEKKQEQEDNLAEITNLL 252
Cdd:pfam05914 162 EEKKQAEEEEKHAELLYDQKRLERDRRALELAKLEEECRRAVNAATKNFNQALAAEQAERRRLEKRQEQEDNLAEIYNHL 241
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 588282768  253 RGDLLSENPQQAASSFGPHRVVPDRWKGMTQEQLEQIRLVQKQQIQEKLRLQEEKRQRDLDWDRRRIQGARATLLFERQQ 332
Cdd:pfam05914 242 TSDLLTENPEVAQSSLGPHRVIPDRWKGMSPEQLKEIRKEQEQQREEKERRREEEKQRDAEWDRQRLELARAALLLEREQ 321
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|.
gi 588282768  333 WRRQRDLRRALDSSNLSLAKEQHLQKKYMN-EVYTNQPTGDYFTQFNTGSR 382
Cdd:pfam05914 322 QRLRRELRRQLDEENLQLAQEQKARQEYLNkEVYTNKPTADYFDQFNTSSR 372
 
Name Accession Description Interval E-value
RIB43A pfam05914
RIB43A; This family consists of several RIB43A-like eukaryotic proteins. Ciliary and flagellar ...
13-382 4.41e-162

RIB43A; This family consists of several RIB43A-like eukaryotic proteins. Ciliary and flagellar microtubules contain a specialized set of protofilaments, termed ribbons, that are composed of tubulin and several associated proteins. RIB43A was first characterized in the unicellular biflagellate, Chlamydomonas reinhardtii although highly related sequences are present in several higher eukaryotes including humans. The function of this protein is unknown although the structure of RIB43A and its association with the specialized protofilament ribbons and with basal bodies is relevant to the proposed role of ribbons in forming and stabilising doublet and triplet microtubules and in organizing their three-dimensional structure. Human RIB43A homologs could represent a structural requirement in centriole replication in dividing cells.


Pssm-ID: 461780 [Multi-domain]  Cd Length: 372  Bit Score: 458.98  E-value: 4.41e-162
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 588282768   13 DLRQDANLAKRRHAELCRQKRVFNARNRIIGGDTEAWDVQVHDQKIKEATEKARHETFAAEMRQNDKIMCILENRKKRDR 92
Cdd:pfam05914   2 DLKEAAAIERRRQREEERKSRIFNARNRTIGVDVEALDKQVEEKKRQEAAEKAREEAFAEEMVQNDKIALMLEKREEEDR 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 588282768   93 KNLCRAINDFQQSFQKPETRREFDLSDPLALKKDLPARQSDNDVRNTISGMQKFMGEDLNFHERKKFQEEQNREWSLQQQ 172
Cdd:pfam05914  82 RRLNKELNEFRQQHQRPETRREFDLNDPDALKKDLPARVSDDDPRCGPSSMQKFEGEDLNREERKKLQQEQMREWLEQQI 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 588282768  173 REWKNARAEQKCAEALYTETRLQFDETAKHLQKLESTTRKAVCASVKDFNKSQAIESVERKKQEKKQEQEDNLAEITNLL 252
Cdd:pfam05914 162 EEKKQAEEEEKHAELLYDQKRLERDRRALELAKLEEECRRAVNAATKNFNQALAAEQAERRRLEKRQEQEDNLAEIYNHL 241
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 588282768  253 RGDLLSENPQQAASSFGPHRVVPDRWKGMTQEQLEQIRLVQKQQIQEKLRLQEEKRQRDLDWDRRRIQGARATLLFERQQ 332
Cdd:pfam05914 242 TSDLLTENPEVAQSSLGPHRVIPDRWKGMSPEQLKEIRKEQEQQREEKERRREEEKQRDAEWDRQRLELARAALLLEREQ 321
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|.
gi 588282768  333 WRRQRDLRRALDSSNLSLAKEQHLQKKYMN-EVYTNQPTGDYFTQFNTGSR 382
Cdd:pfam05914 322 QRLRRELRRQLDEENLQLAQEQKARQEYLNkEVYTNKPTADYFDQFNTSSR 372
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH