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Conserved domains on  [gi|157739942|ref|NP_056280|]
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gem-associated protein 5 isoform 1 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
348-710 3.56e-40

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 154.30  E-value: 3.56e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157739942  348 DKQLLLSTSMDRDVKCWDIATLECSWTLPSLGGFAYSLAFSSvDIGSLAIGVGDGMIRVWNTLSIKnnyDVKNFwQGVKS 427
Cdd:COG2319    89 DGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSP-DGKTLASGSADGTVRLWDLATGK---LLRTL-TGHSG 163

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157739942  428 KVTALCWHPTKEgCLAFGTDDGKVGLYDTYSNKPPQISSTyHKKTVYTLAWGPpvppmslggegDRPSLAlySCGGEGIV 507
Cdd:COG2319   164 AVTSVAFSPDGK-LLASGSDDGTVRLWDLATGKLLRTLTG-HTGAVRSVAFSP-----------DGKLLA--SGSADGTV 228

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157739942  508 lqhnpwKLsgeaFDInklirDTNSIKYKLPVHTE----ISWKADGKIMALGNEDGSIEIFQIPNLKLICTIQQHHKLVNT 583
Cdd:COG2319   229 ------RL----WDL-----ATGKLLRTLTGHSGsvrsVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNS 293

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157739942  584 ISWHhehgsqPELSYLmASGSNNAVIYVHNLKTviesspespvtiTEPYRTLSGHTAKITSVAWSPhhDGR-LVSASYDG 662
Cdd:COG2319   294 VAFS------PDGKLL-ASGSDDGTVRLWDLAT------------GKLLRTLTGHTGAVRSVAFSP--DGKtLASGSDDG 352

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*...
gi 157739942  663 TAQVWDALREEPLCNFRGHRGRLLCVAWSPlDPDCIYSGADDFCVHKW 710
Cdd:COG2319   353 TVRLWDLATGELLRTLTGHTGAVTSVAFSP-DGRTLASGSADGTVRLW 399
WD40 COG2319
WD40 repeat [General function prediction only];
55-456 1.18e-36

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 143.90  E-value: 1.18e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157739942   55 RVIGELVGHTERVSGFTFSHHPGQYnlcATSSDDGTVKIWDVETKTVVTEHALHQHTISTLHWSPRVKDLIVSGDEKGVV 134
Cdd:COG2319    69 ALLATLLGHTAAVLSVAFSPDGRLL---ASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVR 145

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157739942  135 FcyWfNRNDSQHLFI---EPRTIFCLTCSPhheD--LVAIGYKDGIVVIIDIsKKGEVIHRLRGHDDEIHSIAWCPlpge 209
Cdd:COG2319   146 L--W-DLATGKLLRTltgHSGAVTSVAFSP---DgkLLASGSDDGTVRLWDL-ATGKLLRTLTGHTGAVRSVAFSP---- 214

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157739942  210 dclsinqeetseeaeitngnavaqapvtKGCYLATGSKDQTIRIWSCSRGRGVMILKlpflkrrggGIDPTVkerlwLTL 289
Cdd:COG2319   215 ----------------------------DGKLLASGSADGTVRLWDLATGKLLRTLT---------GHSGSV-----RSV 252

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157739942  290 HWpSNQPTQLVSSCFGGELLQWDLtQSWRRKYTLfsassegQNHSRIVFNLC--PlqtedDKQLLLSTSMDRDVKCWDIA 367
Cdd:COG2319   253 AF-SPDGRLLASGSADGTVRLWDL-ATGELLRTL-------TGHSGGVNSVAfsP-----DGKLLASGSDDGTVRLWDLA 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157739942  368 TLECSWTLPSLGGFAYSLAFSSvDIGSLAIGVGDGMIRVWNTLSIKnnydVKNFWQGVKSKVTALCWHPtkEGC-LAFGT 446
Cdd:COG2319   319 TGKLLRTLTGHTGAVRSVAFSP-DGKTLASGSDDGTVRLWDLATGE----LLRTLTGHTGAVTSVAFSP--DGRtLASGS 391

                         410
                  ....*....|
gi 157739942  447 DDGKVGLYDT 456
Cdd:COG2319   392 ADGTVRLWDL 401
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
348-710 3.56e-40

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 154.30  E-value: 3.56e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157739942  348 DKQLLLSTSMDRDVKCWDIATLECSWTLPSLGGFAYSLAFSSvDIGSLAIGVGDGMIRVWNTLSIKnnyDVKNFwQGVKS 427
Cdd:COG2319    89 DGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSP-DGKTLASGSADGTVRLWDLATGK---LLRTL-TGHSG 163

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157739942  428 KVTALCWHPTKEgCLAFGTDDGKVGLYDTYSNKPPQISSTyHKKTVYTLAWGPpvppmslggegDRPSLAlySCGGEGIV 507
Cdd:COG2319   164 AVTSVAFSPDGK-LLASGSDDGTVRLWDLATGKLLRTLTG-HTGAVRSVAFSP-----------DGKLLA--SGSADGTV 228

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157739942  508 lqhnpwKLsgeaFDInklirDTNSIKYKLPVHTE----ISWKADGKIMALGNEDGSIEIFQIPNLKLICTIQQHHKLVNT 583
Cdd:COG2319   229 ------RL----WDL-----ATGKLLRTLTGHSGsvrsVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNS 293

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157739942  584 ISWHhehgsqPELSYLmASGSNNAVIYVHNLKTviesspespvtiTEPYRTLSGHTAKITSVAWSPhhDGR-LVSASYDG 662
Cdd:COG2319   294 VAFS------PDGKLL-ASGSDDGTVRLWDLAT------------GKLLRTLTGHTGAVRSVAFSP--DGKtLASGSDDG 352

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*...
gi 157739942  663 TAQVWDALREEPLCNFRGHRGRLLCVAWSPlDPDCIYSGADDFCVHKW 710
Cdd:COG2319   353 TVRLWDLATGELLRTLTGHTGAVTSVAFSP-DGRTLASGSADGTVRLW 399
WD40 COG2319
WD40 repeat [General function prediction only];
55-456 1.18e-36

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 143.90  E-value: 1.18e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157739942   55 RVIGELVGHTERVSGFTFSHHPGQYnlcATSSDDGTVKIWDVETKTVVTEHALHQHTISTLHWSPRVKDLIVSGDEKGVV 134
Cdd:COG2319    69 ALLATLLGHTAAVLSVAFSPDGRLL---ASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVR 145

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157739942  135 FcyWfNRNDSQHLFI---EPRTIFCLTCSPhheD--LVAIGYKDGIVVIIDIsKKGEVIHRLRGHDDEIHSIAWCPlpge 209
Cdd:COG2319   146 L--W-DLATGKLLRTltgHSGAVTSVAFSP---DgkLLASGSDDGTVRLWDL-ATGKLLRTLTGHTGAVRSVAFSP---- 214

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157739942  210 dclsinqeetseeaeitngnavaqapvtKGCYLATGSKDQTIRIWSCSRGRGVMILKlpflkrrggGIDPTVkerlwLTL 289
Cdd:COG2319   215 ----------------------------DGKLLASGSADGTVRLWDLATGKLLRTLT---------GHSGSV-----RSV 252

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157739942  290 HWpSNQPTQLVSSCFGGELLQWDLtQSWRRKYTLfsassegQNHSRIVFNLC--PlqtedDKQLLLSTSMDRDVKCWDIA 367
Cdd:COG2319   253 AF-SPDGRLLASGSADGTVRLWDL-ATGELLRTL-------TGHSGGVNSVAfsP-----DGKLLASGSDDGTVRLWDLA 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157739942  368 TLECSWTLPSLGGFAYSLAFSSvDIGSLAIGVGDGMIRVWNTLSIKnnydVKNFWQGVKSKVTALCWHPtkEGC-LAFGT 446
Cdd:COG2319   319 TGKLLRTLTGHTGAVRSVAFSP-DGKTLASGSDDGTVRLWDLATGE----LLRTLTGHTGAVTSVAFSP--DGRtLASGS 391

                         410
                  ....*....|
gi 157739942  447 DDGKVGLYDT 456
Cdd:COG2319   392 ADGTVRLWDL 401
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 343-668 1.07e-30

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 123.60  E-value: 1.07e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157739942  343 LQTEDDKQLLLSTSMDRDVKCWDIATLECSWTLPSLGGFAYSLAFSSVDiGSLAIGVGDGMIRVWNtlsIKNNYDVKNFw 422
Cdd:cd00200    15 VAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADG-TYLASGSSDKTIRLWD---LETGECVRTL- 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157739942  423 QGVKSKVTALCWHPTKEgCLAFGTDDGKVGLYDTYSNKPpQISSTYHKKTVYTLAWGPPvppmslggegdrpSLALYSCG 502
Cdd:cd00200    90 TGHTSYVSSVAFSPDGR-ILSSSSRDKTIKVWDVETGKC-LTTLRGHTDWVNSVAFSPD-------------GTFVASSS 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157739942  503 GEGIVlqhnpwKLsgeaFDINklirdTNSIKYKLPVHTE----ISWKADGKIMALGNEDGSIEIFQIPNLKLICTIQQHH 578
Cdd:cd00200   155 QDGTI------KL----WDLR-----TGKCVATLTGHTGevnsVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHE 219

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157739942  579 KLVNTISWHHEhgsqpelSYLMASGSNNAVIYVHNLKTviesspespvtiTEPYRTLSGHTAKITSVAWSPhhDG-RLVS 657
Cdd:cd00200   220 NGVNSVAFSPD-------GYLLASGSEDGTIRVWDLRT------------GECVQTLSGHTNSVTSLAWSP--DGkRLAS 278

                         330
                  ....*....|.
gi 157739942  658 ASYDGTAQVWD 668
Cdd:cd00200   279 GSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 57-408 2.22e-28

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 116.67  E-value: 2.22e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157739942   57 IGELVGHTERVSGFTFSHHPgqyNLCATSSDDGTVKIWDVETKTVVTEHALHQHTISTLHWSPRVKDLIVSGDEKgVVFC 136
Cdd:cd00200     2 RRTLKGHTGGVTCVAFSPDG---KLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDK-TIRL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157739942  137 YWFNRNDSQHLFIE-PRTIFCLTCSPHHEdLVAIGYKDGIVVIIDIsKKGEVIHRLRGHDDEIHSIAWCPLPGedclsin 215
Cdd:cd00200    78 WDLETGECVRTLTGhTSYVSSVAFSPDGR-ILSSSSRDKTIKVWDV-ETGKCLTTLRGHTDWVNSVAFSPDGT------- 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157739942  216 qeetseeaeitngnavaqapvtkgcYLATGSKDQTIRIWSCSRGRGVMILKlpflkrrggGIDPTVkerLWLTLHwPSNQ 295
Cdd:cd00200   149 -------------------------FVASSSQDGTIKLWDLRTGKCVATLT---------GHTGEV---NSVAFS-PDGE 190

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157739942  296 ptQLVSSCFGGELLQWDLtQSWRRKYTLFSassegqnHSRIVFNLCPLQtedDKQLLLSTSMDRDVKCWDIATLECSWTL 375
Cdd:cd00200   191 --KLLSSSSDGTIKLWDL-STGKCLGTLRG-------HENGVNSVAFSP---DGYLLASGSEDGTIRVWDLRTGECVQTL 257

                         330       340       350
                  ....*....|....*....|....*....|...
gi 157739942  376 PSLGGFAYSLAFSSvDIGSLAIGVGDGMIRVWN 408
Cdd:cd00200   258 SGHTNSVTSLAWSP-DGKRLASGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 630-668 1.59e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 51.54  E-value: 1.59e-08
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 157739942    630 EPYRTLSGHTAKITSVAWSPHHDgRLVSASYDGTAQVWD 668
Cdd:smart00320    3 ELLKTLKGHTGPVTSVAFSPDGK-YLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 599-710 4.87e-08

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 57.79  E-value: 4.87e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157739942  599 LMASGSNNAVIYVHNLKTVIESSPEspvtITEPYRTLSGHTaKITSVAWSPHHDGRLVSASYDGTAQVWDALREEPLCNF 678
Cdd:PLN00181  497 FFATAGVNKKIKIFECESIIKDGRD----IHYPVVELASRS-KLSGICWNSYIKSQVASSNFEGVVQVWDVARSQLVTEM 571

                          90       100       110
                  ....*....|....*....|....*....|..
gi 157739942  679 RGHRGRLLCVAWSPLDPDCIYSGADDFCVHKW 710
Cdd:PLN00181  572 KEHEKRVWSIDYSSADPTLLASGSDDGSVKLW 603
WD40 pfam00400
WD domain, G-beta repeat;
630-668 1.14e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 49.27  E-value: 1.14e-07
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 157739942   630 EPYRTLSGHTAKITSVAWSPHHDgRLVSASYDGTAQVWD 668
Cdd:pfam00400    2 KLLKTLEGHTGSVTSLAFSPDGK-LLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 53-95 8.67e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.84  E-value: 8.67e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 157739942     53 PFRVIGELVGHTERVSGFTFSHHpgqYNLCATSSDDGTVKIWD 95
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSPD---GKYLASGSDDGTIKLWD 40
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 117-204 2.92e-05

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 44.19  E-value: 2.92e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157739942   117 WSPRvKDLIVSGDEKGVVfcyWFNRNDSQHLF-IEP----RTIFCLTCSPHhEDLVAIGYKDGIVVIIDISkKGEVIHRL 191
Cdd:pfam12894    3 WCPT-MDLIALATEDGEL---LLHRLNWQRVWtLSPdkedLEVTSLAWRPD-GKLLAVGYSDGTVRLLDAE-NGKIVHHF 76

                           90
                   ....*....|...
gi 157739942   192 RGHDDEIHSIAWC 204
Cdd:pfam12894   77 SAGSDLITCLGWG 89
PTZ00421 PTZ00421
coronin; Provisional
 57-118 4.67e-04

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 44.50  E-value: 4.67e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 157739942   57 IGELVGHTERVSGFTFshHPGQYNLCATSSDDGTVKIWDVETKTVVTEHALHQHTISTLHWS 118
Cdd:PTZ00421  118 IVHLQGHTKKVGIVSF--HPSAMNVLASAGADMVVNVWDVERGKAVEVIKCHSDQITSLEWN 177
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
348-710 3.56e-40

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 154.30  E-value: 3.56e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157739942  348 DKQLLLSTSMDRDVKCWDIATLECSWTLPSLGGFAYSLAFSSvDIGSLAIGVGDGMIRVWNTLSIKnnyDVKNFwQGVKS 427
Cdd:COG2319    89 DGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSP-DGKTLASGSADGTVRLWDLATGK---LLRTL-TGHSG 163

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157739942  428 KVTALCWHPTKEgCLAFGTDDGKVGLYDTYSNKPPQISSTyHKKTVYTLAWGPpvppmslggegDRPSLAlySCGGEGIV 507
Cdd:COG2319   164 AVTSVAFSPDGK-LLASGSDDGTVRLWDLATGKLLRTLTG-HTGAVRSVAFSP-----------DGKLLA--SGSADGTV 228

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157739942  508 lqhnpwKLsgeaFDInklirDTNSIKYKLPVHTE----ISWKADGKIMALGNEDGSIEIFQIPNLKLICTIQQHHKLVNT 583
Cdd:COG2319   229 ------RL----WDL-----ATGKLLRTLTGHSGsvrsVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNS 293

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157739942  584 ISWHhehgsqPELSYLmASGSNNAVIYVHNLKTviesspespvtiTEPYRTLSGHTAKITSVAWSPhhDGR-LVSASYDG 662
Cdd:COG2319   294 VAFS------PDGKLL-ASGSDDGTVRLWDLAT------------GKLLRTLTGHTGAVRSVAFSP--DGKtLASGSDDG 352

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*...
gi 157739942  663 TAQVWDALREEPLCNFRGHRGRLLCVAWSPlDPDCIYSGADDFCVHKW 710
Cdd:COG2319   353 TVRLWDLATGELLRTLTGHTGAVTSVAFSP-DGRTLASGSADGTVRLW 399
WD40 COG2319
WD40 repeat [General function prediction only];
347-710 4.34e-37

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 145.44  E-value: 4.34e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157739942  347 DDKQLLLSTSMDRDVKCWDIATLECSWTLPSLGGFAYSLAFSSvDIGSLAIGVGDGMIRVWNTLSIKnnydVKNFWQGVK 426
Cdd:COG2319    46 PDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSP-DGRLLASASADGTVRLWDLATGL----LLRTLTGHT 120

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157739942  427 SKVTALCWHPtkEGC-LAFGTDDGKVGLYDTYSNKPPQISSTyHKKTVYTLAWGPpvppmslggEGDRpslaLYSCGGEG 505
Cdd:COG2319   121 GAVRSVAFSP--DGKtLASGSADGTVRLWDLATGKLLRTLTG-HSGAVTSVAFSP---------DGKL----LASGSDDG 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157739942  506 IVLQhnpWKLSGeafdiNKLIRdtnsikyKLPVHTE----ISWKADGKIMALGNEDGSIEIFQIPNLKLICTIQQHHKLV 581
Cdd:COG2319   185 TVRL---WDLAT-----GKLLR-------TLTGHTGavrsVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSV 249

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157739942  582 NTISWHHEhGSqpelsyLMASGSNNAVIYVHNLKTviesspespvtiTEPYRTLSGHTAKITSVAWSPhhDGR-LVSASY 660
Cdd:COG2319   250 RSVAFSPD-GR------LLASGSADGTVRLWDLAT------------GELLRTLTGHSGGVNSVAFSP--DGKlLASGSD 308

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|
gi 157739942  661 DGTAQVWDALREEPLCNFRGHRGRLLCVAWSPlDPDCIYSGADDFCVHKW 710
Cdd:COG2319   309 DGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKTLASGSDDGTVRLW 357
WD40 COG2319
WD40 repeat [General function prediction only];
55-456 1.18e-36

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 143.90  E-value: 1.18e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157739942   55 RVIGELVGHTERVSGFTFSHHPGQYnlcATSSDDGTVKIWDVETKTVVTEHALHQHTISTLHWSPRVKDLIVSGDEKGVV 134
Cdd:COG2319    69 ALLATLLGHTAAVLSVAFSPDGRLL---ASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVR 145

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157739942  135 FcyWfNRNDSQHLFI---EPRTIFCLTCSPhheD--LVAIGYKDGIVVIIDIsKKGEVIHRLRGHDDEIHSIAWCPlpge 209
Cdd:COG2319   146 L--W-DLATGKLLRTltgHSGAVTSVAFSP---DgkLLASGSDDGTVRLWDL-ATGKLLRTLTGHTGAVRSVAFSP---- 214

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157739942  210 dclsinqeetseeaeitngnavaqapvtKGCYLATGSKDQTIRIWSCSRGRGVMILKlpflkrrggGIDPTVkerlwLTL 289
Cdd:COG2319   215 ----------------------------DGKLLASGSADGTVRLWDLATGKLLRTLT---------GHSGSV-----RSV 252

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157739942  290 HWpSNQPTQLVSSCFGGELLQWDLtQSWRRKYTLfsassegQNHSRIVFNLC--PlqtedDKQLLLSTSMDRDVKCWDIA 367
Cdd:COG2319   253 AF-SPDGRLLASGSADGTVRLWDL-ATGELLRTL-------TGHSGGVNSVAfsP-----DGKLLASGSDDGTVRLWDLA 318

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157739942  368 TLECSWTLPSLGGFAYSLAFSSvDIGSLAIGVGDGMIRVWNTLSIKnnydVKNFWQGVKSKVTALCWHPtkEGC-LAFGT 446
Cdd:COG2319   319 TGKLLRTLTGHTGAVRSVAFSP-DGKTLASGSDDGTVRLWDLATGE----LLRTLTGHTGAVTSVAFSP--DGRtLASGS 391

                         410
                  ....*....|
gi 157739942  447 DDGKVGLYDT 456
Cdd:COG2319   392 ADGTVRLWDL 401
WD40 COG2319
WD40 repeat [General function prediction only];
239-669 1.99e-34

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 137.35  E-value: 1.99e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157739942  239 GCYLATGSKDQTIRIWSCSRGRgvmilklpfLKRRGGGIDPTVKErlwLTLHwPSNQptQLVSSCFGGELLQWDLtQSWR 318
Cdd:COG2319    90 GRLLASASADGTVRLWDLATGL---------LLRTLTGHTGAVRS---VAFS-PDGK--TLASGSADGTVRLWDL-ATGK 153

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157739942  319 RKYTLfsassegQNHSRIVFNLC--PlqtedDKQLLLSTSMDRDVKCWDIATLECSWTLPSLGGFAYSLAFSSvDIGSLA 396
Cdd:COG2319   154 LLRTL-------TGHSGAVTSVAfsP-----DGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKLLA 220

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157739942  397 IGVGDGMIRVWNTlsikNNYDVKNFWQGVKSKVTALCWHPTKEgCLAFGTDDGKVGLYDTYSNKPPQIsSTYHKKTVYTL 476
Cdd:COG2319   221 SGSADGTVRLWDL----ATGKLLRTLTGHSGSVRSVAFSPDGR-LLASGSADGTVRLWDLATGELLRT-LTGHSGGVNSV 294

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157739942  477 AWGPpvppmslggegdrpslalyscggegivlqhnpwklsgeafdinklirdtnsikyklpvhteiswkaDGKIMALGNE 556
Cdd:COG2319   295 AFSP------------------------------------------------------------------DGKLLASGSD 308

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157739942  557 DGSIEIFQIPNLKLICTIQQHHKLVNTISWHhehgsqPELSYLmASGSNNAVIYVHNLKTviesspespvtiTEPYRTLS 636
Cdd:COG2319   309 DGTVRLWDLATGKLLRTLTGHTGAVRSVAFS------PDGKTL-ASGSDDGTVRLWDLAT------------GELLRTLT 369

                         410       420       430
                  ....*....|....*....|....*....|....
gi 157739942  637 GHTAKITSVAWSPhhDGR-LVSASYDGTAQVWDA 669
Cdd:COG2319   370 GHTGAVTSVAFSP--DGRtLASGSADGTVRLWDL 401
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 343-668 1.07e-30

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 123.60  E-value: 1.07e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157739942  343 LQTEDDKQLLLSTSMDRDVKCWDIATLECSWTLPSLGGFAYSLAFSSVDiGSLAIGVGDGMIRVWNtlsIKNNYDVKNFw 422
Cdd:cd00200    15 VAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADG-TYLASGSSDKTIRLWD---LETGECVRTL- 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157739942  423 QGVKSKVTALCWHPTKEgCLAFGTDDGKVGLYDTYSNKPpQISSTYHKKTVYTLAWGPPvppmslggegdrpSLALYSCG 502
Cdd:cd00200    90 TGHTSYVSSVAFSPDGR-ILSSSSRDKTIKVWDVETGKC-LTTLRGHTDWVNSVAFSPD-------------GTFVASSS 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157739942  503 GEGIVlqhnpwKLsgeaFDINklirdTNSIKYKLPVHTE----ISWKADGKIMALGNEDGSIEIFQIPNLKLICTIQQHH 578
Cdd:cd00200   155 QDGTI------KL----WDLR-----TGKCVATLTGHTGevnsVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHE 219

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157739942  579 KLVNTISWHHEhgsqpelSYLMASGSNNAVIYVHNLKTviesspespvtiTEPYRTLSGHTAKITSVAWSPhhDG-RLVS 657
Cdd:cd00200   220 NGVNSVAFSPD-------GYLLASGSEDGTIRVWDLRT------------GECVQTLSGHTNSVTSLAWSP--DGkRLAS 278

                         330
                  ....*....|.
gi 157739942  658 ASYDGTAQVWD 668
Cdd:cd00200   279 GSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 57-408 2.22e-28

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 116.67  E-value: 2.22e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157739942   57 IGELVGHTERVSGFTFSHHPgqyNLCATSSDDGTVKIWDVETKTVVTEHALHQHTISTLHWSPRVKDLIVSGDEKgVVFC 136
Cdd:cd00200     2 RRTLKGHTGGVTCVAFSPDG---KLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDK-TIRL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157739942  137 YWFNRNDSQHLFIE-PRTIFCLTCSPHHEdLVAIGYKDGIVVIIDIsKKGEVIHRLRGHDDEIHSIAWCPLPGedclsin 215
Cdd:cd00200    78 WDLETGECVRTLTGhTSYVSSVAFSPDGR-ILSSSSRDKTIKVWDV-ETGKCLTTLRGHTDWVNSVAFSPDGT------- 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157739942  216 qeetseeaeitngnavaqapvtkgcYLATGSKDQTIRIWSCSRGRGVMILKlpflkrrggGIDPTVkerLWLTLHwPSNQ 295
Cdd:cd00200   149 -------------------------FVASSSQDGTIKLWDLRTGKCVATLT---------GHTGEV---NSVAFS-PDGE 190

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157739942  296 ptQLVSSCFGGELLQWDLtQSWRRKYTLFSassegqnHSRIVFNLCPLQtedDKQLLLSTSMDRDVKCWDIATLECSWTL 375
Cdd:cd00200   191 --KLLSSSSDGTIKLWDL-STGKCLGTLRG-------HENGVNSVAFSP---DGYLLASGSEDGTIRVWDLRTGECVQTL 257

                         330       340       350
                  ....*....|....*....|....*....|...
gi 157739942  376 PSLGGFAYSLAFSSvDIGSLAIGVGDGMIRVWN 408
Cdd:cd00200   258 SGHTNSVTSLAWSP-DGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 422-704 3.61e-25

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 107.42  E-value: 3.61e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157739942  422 WQGVKSKVTALCWHPTKEGcLAFGTDDGKVGLYDTYSNKpPQISSTYHKKTVYTLAWGPpvppmslggegDRPSLAlySC 501
Cdd:cd00200     5 LKGHTGGVTCVAFSPDGKL-LATGSGDGTIKVWDLETGE-LLRTLKGHTGPVRDVAASA-----------DGTYLA--SG 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157739942  502 GGEGIVlqhnpwKLsgeaFDINklirdTNSIKYKLPVHTE----ISWKADGKIMALGNEDGSIEIFQIPNLKLICTIQQH 577
Cdd:cd00200    70 SSDKTI------RL----WDLE-----TGECVRTLTGHTSyvssVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGH 134

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157739942  578 HKLVNTISWHHEHGsqpelsyLMASGSNNAVIYVHNLKTviesspespvtiTEPYRTLSGHTAKITSVAWSPhhDG-RLV 656
Cdd:cd00200   135 TDWVNSVAFSPDGT-------FVASSSQDGTIKLWDLRT------------GKCVATLTGHTGEVNSVAFSP--DGeKLL 193

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 157739942  657 SASYDGTAQVWDALREEPLCNFRGHRGRLLCVAWSPlDPDCIYSGADD 704
Cdd:cd00200   194 SSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSP-DGYLLASGSED 240
WD40 COG2319
WD40 repeat [General function prediction only];
348-710 5.87e-25

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 109.23  E-value: 5.87e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157739942  348 DKQLLLSTSMDRDVKCWDIATLECSWTLPSLGGFAYSLAFSSvDIGSLAIGVGDGMIRVWNTLSIKnnydVKNFWQGVKS 427
Cdd:COG2319     5 DGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASP-DGARLAAGAGDLTLLLLDAAAGA----LLATLLGHTA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157739942  428 KVTALCWHPTKEGcLAFGTDDGKVGLYDTYSNKPPQISsTYHKKTVYTLAWGPpvppmslggegdrpslalyscggegiv 507
Cdd:COG2319    80 AVLSVAFSPDGRL-LASASADGTVRLWDLATGLLLRTL-TGHTGAVRSVAFSP--------------------------- 130

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157739942  508 lqhnpwklsgeafdinklirdtnsikyklpvhteiswkaDGKIMALGNEDGSIEIFQIPNLKLICTIQQHHKLVNTISWH 587
Cdd:COG2319   131 ---------------------------------------DGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFS 171

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157739942  588 HEhgsqpelSYLMASGSNNAVIYVHNLKTviesspespvtiTEPYRTLSGHTAKITSVAWSPhhDGR-LVSASYDGTAQV 666
Cdd:COG2319   172 PD-------GKLLASGSDDGTVRLWDLAT------------GKLLRTLTGHTGAVRSVAFSP--DGKlLASGSADGTVRL 230

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....
gi 157739942  667 WDALREEPLCNFRGHRGRLLCVAWSPlDPDCIYSGADDFCVHKW 710
Cdd:COG2319   231 WDLATGKLLRTLTGHSGSVRSVAFSP-DGRLLASGSADGTVRLW 273
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 51-255 1.10e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 94.32  E-value: 1.10e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157739942   51 TPPFRVIGELVGHTERVSGFTFSHHPGqynLCATSSDDGTVKIWDVETKTVVTEHALHQHTISTLHWSPRVKDLIVSGDE 130
Cdd:cd00200   122 VETGKCLTTLRGHTDWVNSVAFSPDGT---FVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSD 198

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157739942  131 kGVVFCYWFNRNDSQHLFIEPRTIFCLTCSPHHEDLVAIGYKDGIVVIIDIsKKGEVIHRLRGHDDEIHSIAWCPlpged 210
Cdd:cd00200   199 -GTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDL-RTGECVQTLSGHTNSVTSLAWSP----- 271

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 157739942  211 clsinqeetseeaeitngnavaqapvtKGCYLATGSKDQTIRIWS 255
Cdd:cd00200   272 ---------------------------DGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 469-727 6.81e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 91.63  E-value: 6.81e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157739942  469 HKKTVYTLAWGPPVPpmslggegdrpslALYSCGGEGIVLQhnpWKLsgeafdinklirDTNSIKYKLPVHTE----ISW 544
Cdd:cd00200     8 HTGGVTCVAFSPDGK-------------LLATGSGDGTIKV---WDL------------ETGELLRTLKGHTGpvrdVAA 59

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157739942  545 KADGKIMALGNEDGSIEIFQIPNLKLICTIQQHHKLVNTISWHHEHgsqpelsYLMASGSNNAVIYVHNLKTviesspes 624
Cdd:cd00200    60 SADGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDG-------RILSSSSRDKTIKVWDVET-------- 124

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157739942  625 pvtiTEPYRTLSGHTAKITSVAWSPhHDGRLVSASYDGTAQVWDALREEPLCNFRGHRGRLLCVAWSPlDPDCIYSGADD 704
Cdd:cd00200   125 ----GKCLTTLRGHTDWVNSVAFSP-DGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSP-DGEKLLSSSSD 198

                         250       260
                  ....*....|....*....|...
gi 157739942  705 FCVHKWLTSMQDHSRPPQGKKSI 727
Cdd:cd00200   199 GTIKLWDLSTGKCLGTLRGHENG 221
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 570-720 2.08e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 81.61  E-value: 2.08e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157739942  570 LICTIQQHHKLVNTISWHhehgsqPELSYLmASGSNNAVIYVHNLKTviesspespvtiTEPYRTLSGHTAKITSVAWSP 649
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFS------PDGKLL-ATGSGDGTIKVWDLET------------GELLRTLKGHTGPVRDVAASA 61

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 157739942  650 HHDgRLVSASYDGTAQVWDALREEPLCNFRGHRGRLLCVAWSPlDPDCIYSGADDFCVHKW-------LTSMQDHSRP 720
Cdd:cd00200    62 DGT-YLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSP-DGRILSSSSRDKTIKVWdvetgkcLTTLRGHTDW 137
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 630-668 1.59e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 51.54  E-value: 1.59e-08
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 157739942    630 EPYRTLSGHTAKITSVAWSPHHDgRLVSASYDGTAQVWD 668
Cdd:smart00320    3 ELLKTLKGHTGPVTSVAFSPDGK-YLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 599-710 4.87e-08

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 57.79  E-value: 4.87e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157739942  599 LMASGSNNAVIYVHNLKTVIESSPEspvtITEPYRTLSGHTaKITSVAWSPHHDGRLVSASYDGTAQVWDALREEPLCNF 678
Cdd:PLN00181  497 FFATAGVNKKIKIFECESIIKDGRD----IHYPVVELASRS-KLSGICWNSYIKSQVASSNFEGVVQVWDVARSQLVTEM 571

                          90       100       110
                  ....*....|....*....|....*....|..
gi 157739942  679 RGHRGRLLCVAWSPLDPDCIYSGADDFCVHKW 710
Cdd:PLN00181  572 KEHEKRVWSIDYSSADPTLLASGSDDGSVKLW 603
WD40 pfam00400
WD domain, G-beta repeat;
630-668 1.14e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 49.27  E-value: 1.14e-07
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 157739942   630 EPYRTLSGHTAKITSVAWSPHHDgRLVSASYDGTAQVWD 668
Cdd:pfam00400    2 KLLKTLEGHTGSVTSLAFSPDGK-LLASGSDDGTVKVWD 39
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 540-586 7.36e-06

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 45.73  E-value: 7.36e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 157739942   540 TEISWKADGKIMALGNEDGSIEIFQIPNLKLICTIQQHHKLVNTISW 586
Cdd:pfam12894   42 TSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGSDLITCLGW 88
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 53-95 8.67e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.84  E-value: 8.67e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 157739942     53 PFRVIGELVGHTERVSGFTFSHHpgqYNLCATSSDDGTVKIWD 95
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSPD---GKYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 349-473 9.81e-06

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 50.47  E-value: 9.81e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157739942  349 KQLLLSTSMDRDVKCWDIATLECSWTLPSLGGFAYSLAFSSVDIGSLAIGVGDGMIRVWntlSIKNNYDVKNfwqgVKSK 428
Cdd:PLN00181  545 KSQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLASGSDDGSVKLW---SINQGVSIGT----IKTK 617

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 157739942  429 VTALCWH-PTKEG-CLAFGTDDGKVGLYDTYSNKPPQISSTYHKKTV 473
Cdd:PLN00181  618 ANICCVQfPSESGrSLAFGSADHKVYYYDLRNPKLPLCTMIGHSKTV 664
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 117-204 2.92e-05

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 44.19  E-value: 2.92e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157739942   117 WSPRvKDLIVSGDEKGVVfcyWFNRNDSQHLF-IEP----RTIFCLTCSPHhEDLVAIGYKDGIVVIIDISkKGEVIHRL 191
Cdd:pfam12894    3 WCPT-MDLIALATEDGEL---LLHRLNWQRVWtLSPdkedLEVTSLAWRPD-GKLLAVGYSDGTVRLLDAE-NGKIVHHF 76

                           90
                   ....*....|...
gi 157739942   192 RGHDDEIHSIAWC 204
Cdd:pfam12894   77 SAGSDLITCLGWG 89
WD40 pfam00400
WD domain, G-beta repeat;
54-95 5.30e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.56  E-value: 5.30e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 157739942    54 FRVIGELVGHTERVSGFTFSHHPgqyNLCATSSDDGTVKIWD 95
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSPDG---KLLASGSDDGTVKVWD 39
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 395-479 1.68e-04

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 41.88  E-value: 1.68e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157739942   395 LAIGVGDGMI--------RVWnTLSIKNNydvknfwqgvKSKVTALCWHPtKEGCLAFGTDDGKVGLYDTYSNKpPQISS 466
Cdd:pfam12894   10 IALATEDGELllhrlnwqRVW-TLSPDKE----------DLEVTSLAWRP-DGKLLAVGYSDGTVRLLDAENGK-IVHHF 76

                           90
                   ....*....|...
gi 157739942   467 TYHKKTVYTLAWG 479
Cdd:pfam12894   77 SAGSDLITCLGWG 89
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 546-681 1.85e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 46.23  E-value: 1.85e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157739942  546 ADGKIMALGNEDGSIEIFQIPNLKLICTIQQHHKlVNTISWHHEHGSQpelsylMASGSNNAVIYVHNLKtviesSPESP 625
Cdd:PLN00181  586 ADPTLLASGSDDGSVKLWSINQGVSIGTIKTKAN-ICCVQFPSESGRS------LAFGSADHKVYYYDLR-----NPKLP 653

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 157739942  626 VTitepyrTLSGHTAKITSVAWSphHDGRLVSASYDGTAQVWD------ALREEPLCNFRGH 681
Cdd:PLN00181  654 LC------TMIGHSKTVSYVRFV--DSSTLVSSSTDNTLKLWDlsmsisGINETPLHSFMGH 707
WD40 COG2319
WD40 repeat [General function prediction only];
55-98 2.20e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 45.29  E-value: 2.20e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 157739942   55 RVIGELVGHTERVSGFTFSHHpGQYnLcATSSDDGTVKIWDVET 98
Cdd:COG2319   363 ELLRTLTGHTGAVTSVAFSPD-GRT-L-ASGSADGTVRLWDLAT 403
PTZ00420 PTZ00420
coronin; Provisional
 631-710 4.30e-04

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 44.94  E-value: 4.30e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157739942  631 PYRTLSGHTAKITSVAWSPHHDGRLVSASYDGTAQVWDALRE--------EPLCNFRGHRGRLLCVAWSPLDPDCIYSGA 702
Cdd:PTZ00420   66 PVIKLKGHTSSILDLQFNPCFSEILASGSEDLTIRVWEIPHNdesvkeikDPQCILKGHKKKISIIDWNPMNYYIMCSSG 145


                  ....*...
gi 157739942  703 DDFCVHKW 710
Cdd:PTZ00420  146 FDSFVNIW 153
PTZ00421 PTZ00421
coronin; Provisional
 57-118 4.67e-04

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 44.50  E-value: 4.67e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 157739942   57 IGELVGHTERVSGFTFshHPGQYNLCATSSDDGTVKIWDVETKTVVTEHALHQHTISTLHWS 118
Cdd:PTZ00421  118 IVHLQGHTKKVGIVSF--HPSAMNVLASAGADMVVNVWDVERGKAVEVIKCHSDQITSLEWN 177
PTZ00420 PTZ00420
coronin; Provisional
 594-673 1.83e-03

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 42.63  E-value: 1.83e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 157739942  594 PELSYLMASGSNNAVIYVHNLKTVIESSPEspvtITEPYRTLSGHTAKITSVAWSPHHDGRLVSASYDGTAQVWDALREE 673
Cdd:PTZ00420   84 PCFSEILASGSEDLTIRVWEIPHNDESVKE----IKDPQCILKGHKKKISIIDWNPMNYYIMCSSGFDSFVNIWDIENEK 159
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 673-710 1.84e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.29  E-value: 1.84e-03
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 157739942    673 EPLCNFRGHRGRLLCVAWSPlDPDCIYSGADDFCVHKW 710
Cdd:smart00320    3 ELLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
673-710 6.08e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.78  E-value: 6.08e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 157739942   673 EPLCNFRGHRGRLLCVAWSPlDPDCIYSGADDFCVHKW 710
Cdd:pfam00400    2 KLLKTLEGHTGSVTSLAFSP-DGKLLASGSDDGTVKVW 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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