NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|23943785|ref|NP_056279|]
View 

sclerostin domain-containing protein 1 precursor [Homo sapiens]

Protein Classification

Sclerostin domain-containing protein( domain architecture ID 10527218)

Sclerostin domain-containing protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Sclerostin pfam05463
Sclerostin (SOST); This family contains several mammalian sclerostin (SOST) proteins. SOST is ...
 6-206 5.43e-120

Sclerostin (SOST); This family contains several mammalian sclerostin (SOST) proteins. SOST is thought to suppress bone formation. Mutations of the SOST gene lead to sclerosteosis, a progressive sclerosing bone dysplasia with an autosomal recessive mode of inheritance. Radiologically, it is characterized by a generalized hyperostosis and sclerosis leading to a markedly thickened and sclerotic skull, with mandible, ribs, clavicles and all long bones also being affected. Due to narrowing of the foramina of the cranial nerves, facial nerve palsy, hearing loss and atrophy of the optic nerves can occur. Sclerosteosis is clinically and radiologically very similar to van Buchem disease, mainly differentiated by hand malformations and a large stature in sclerosteosis patients.


:

Pssm-ID: 398883  Cd Length: 198  Bit Score: 338.42  E-value: 5.43e-120
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23943785     6 IHFYLLPLACILMKSCLAFKNDATEILYSHVVKPVPaHPSSNSTLNQARNGGRHFSNTgLDRNTRVQVGCRELRSTKYIS 85
Cdd:pfam05463   1 MQPSLLPLLCILMHSCFAFKNDATEILYSHVEKPEP-EPENNSTLNRARNGGRHPHSP-YDRTDVHQVGCRELRSTKYIS 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23943785    86 DGQCTSISPLKELVCAGECLPLPVLPNWIGGGYgtkYWSRRSSQEWRCVNDKTRTQRIQLQCQDGSTRTYKITVVTACKC 165
Cdd:pfam05463  79 DGQCTSIKPVKELVCAGECLPLPLLPNWIGGGY---YWSRRSSQEWRCVNDRTRTQRIQLQCQDGTTRTYKVTVVTSCKC 155

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 23943785   166 KRYTRQHNESSHNFESMSPAKPV--QHHRERKRASKSSKHSMS 206
Cdd:pfam05463 156 KRYTRQHNESSHNDEGPSPAKPQkgRHPRPKKRGSKASKHELS 198
 
Name Accession Description Interval E-value
Sclerostin pfam05463
Sclerostin (SOST); This family contains several mammalian sclerostin (SOST) proteins. SOST is ...
 6-206 5.43e-120

Sclerostin (SOST); This family contains several mammalian sclerostin (SOST) proteins. SOST is thought to suppress bone formation. Mutations of the SOST gene lead to sclerosteosis, a progressive sclerosing bone dysplasia with an autosomal recessive mode of inheritance. Radiologically, it is characterized by a generalized hyperostosis and sclerosis leading to a markedly thickened and sclerotic skull, with mandible, ribs, clavicles and all long bones also being affected. Due to narrowing of the foramina of the cranial nerves, facial nerve palsy, hearing loss and atrophy of the optic nerves can occur. Sclerosteosis is clinically and radiologically very similar to van Buchem disease, mainly differentiated by hand malformations and a large stature in sclerosteosis patients.


Pssm-ID: 398883  Cd Length: 198  Bit Score: 338.42  E-value: 5.43e-120
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23943785     6 IHFYLLPLACILMKSCLAFKNDATEILYSHVVKPVPaHPSSNSTLNQARNGGRHFSNTgLDRNTRVQVGCRELRSTKYIS 85
Cdd:pfam05463   1 MQPSLLPLLCILMHSCFAFKNDATEILYSHVEKPEP-EPENNSTLNRARNGGRHPHSP-YDRTDVHQVGCRELRSTKYIS 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23943785    86 DGQCTSISPLKELVCAGECLPLPVLPNWIGGGYgtkYWSRRSSQEWRCVNDKTRTQRIQLQCQDGSTRTYKITVVTACKC 165
Cdd:pfam05463  79 DGQCTSIKPVKELVCAGECLPLPLLPNWIGGGY---YWSRRSSQEWRCVNDRTRTQRIQLQCQDGTTRTYKVTVVTSCKC 155

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 23943785   166 KRYTRQHNESSHNFESMSPAKPV--QHHRERKRASKSSKHSMS 206
Cdd:pfam05463 156 KRYTRQHNESSHNDEGPSPAKPQkgRHPRPKKRGSKASKHELS 198
 
Name Accession Description Interval E-value
Sclerostin pfam05463
Sclerostin (SOST); This family contains several mammalian sclerostin (SOST) proteins. SOST is ...
 6-206 5.43e-120

Sclerostin (SOST); This family contains several mammalian sclerostin (SOST) proteins. SOST is thought to suppress bone formation. Mutations of the SOST gene lead to sclerosteosis, a progressive sclerosing bone dysplasia with an autosomal recessive mode of inheritance. Radiologically, it is characterized by a generalized hyperostosis and sclerosis leading to a markedly thickened and sclerotic skull, with mandible, ribs, clavicles and all long bones also being affected. Due to narrowing of the foramina of the cranial nerves, facial nerve palsy, hearing loss and atrophy of the optic nerves can occur. Sclerosteosis is clinically and radiologically very similar to van Buchem disease, mainly differentiated by hand malformations and a large stature in sclerosteosis patients.


Pssm-ID: 398883  Cd Length: 198  Bit Score: 338.42  E-value: 5.43e-120
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23943785     6 IHFYLLPLACILMKSCLAFKNDATEILYSHVVKPVPaHPSSNSTLNQARNGGRHFSNTgLDRNTRVQVGCRELRSTKYIS 85
Cdd:pfam05463   1 MQPSLLPLLCILMHSCFAFKNDATEILYSHVEKPEP-EPENNSTLNRARNGGRHPHSP-YDRTDVHQVGCRELRSTKYIS 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23943785    86 DGQCTSISPLKELVCAGECLPLPVLPNWIGGGYgtkYWSRRSSQEWRCVNDKTRTQRIQLQCQDGSTRTYKITVVTACKC 165
Cdd:pfam05463  79 DGQCTSIKPVKELVCAGECLPLPLLPNWIGGGY---YWSRRSSQEWRCVNDRTRTQRIQLQCQDGTTRTYKVTVVTSCKC 155

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 23943785   166 KRYTRQHNESSHNFESMSPAKPV--QHHRERKRASKSSKHSMS 206
Cdd:pfam05463 156 KRYTRQHNESSHNDEGPSPAKPQkgRHPRPKKRGSKASKHELS 198
DAN pfam03045
DAN domain; This domain contains 9 conserved cysteines and is extracellular. Therefore the ...
 49-166 1.22e-12

DAN domain; This domain contains 9 conserved cysteines and is extracellular. Therefore the cysteines may form disulphide bridges. This family of proteins has been termed the DAN family after the first member to be reported. This family includes DAN, Cerberus and Gremlin. The gremlin protein is an antagonist of bone morphogenetic protein signaling. It is postulated that all members of this family antagonize different TGF beta pfam00019 ligands. Recent work shows that the DAN protein is not an efficient antagonist of BMP-2/4 class signals, we found that DAN was able to interact with GDF-5 in a frog embryo assay, suggesting that DAN may regulate signaling by the GDF-5/6/7 class of BMPs in vivo.


Pssm-ID: 460786  Cd Length: 108  Bit Score: 61.53  E-value: 1.22e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23943785    49 TLNQARNGGRHfsntGLDRNTRVQVGCRELRSTKYISDGQCTSIsPLKELVCAGECLPLpVLPNWIGGGYgtkyWSRRSS 128
Cdd:pfam03045   2 FLNRAKPGALL----PTKRRELKRDWCRTQPFTQTITEEGCLSR-TVQNRFCYGQCNSF-YIPNSIGRGK----WSFASC 71

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 23943785   129 QewRCVNDKTRTQRIQLQCQDGS-TRTYKITVVTACKCK 166
Cdd:pfam03045  72 S--RCKPSKFTTVTVTLNCPGGPpTRTKRVMRVKECKCK 108
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH