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Conserved domains on  [gi|1423310367|ref|NP_056235|]
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DDB1- and CUL4-associated factor 13 isoform 1 [Homo sapiens]

Protein Classification

WD repeat DCAF13/WDSOF1 family protein( domain architecture ID 10078020)

WD repeat DCAF13/WDSOF1 family protein may play a role in ribosomal RNA processing

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Sof1 pfam04158
Sof1-like domain; Sof1 is essential for cell growth and is a component of the nucleolar rRNA ...
 354-435 3.08e-44

Sof1-like domain; Sof1 is essential for cell growth and is a component of the nucleolar rRNA processing machinery.


:

Pssm-ID: 427753  Cd Length: 87  Bit Score: 149.18  E-value: 3.08e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423310367 354 ANASEKLGVLTSREKAAKDYNQKLKEKFQHYPHIKRIARHRHLPKSIYSQIQEQRIMKEARRRKEVNRIKHSKPGSVPLV 433
Cdd:pfam04158   1 ANASEKLGVLSPRERAALEYNEALKEKYKHMPEIRRIARHRHVPKAIYKAQKIKREMLEARKRKEENRRKHSKPGSVPRK 80


                  ..
gi 1423310367 434 SE 435
Cdd:pfam04158  81 PE 82
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 59-353 5.96e-41

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 147.48  E-value: 5.96e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423310367  59 LASLDGHRDGVNCLAKHPEKlATVLSGACDGEVRIWNLTQRNCIRTIQAHEGFVRGICTRFCGTSFFTVGDDKTVKQWKM 138
Cdd:cd00200     2 RRTLKGHTGGVTCVAFSPDG-KLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423310367 139 DGPgygdeeEPLHTILG--KTVYTgIDHHWKEAVFATCGQQVDIWDEQRTNPICSMTWGF--DSISSVKFNPIETFLLGS 214
Cdd:cd00200    81 ETG------ECVRTLTGhtSYVSS-VAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGhtDWVNSVAFSPDGTFVASS 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423310367 215 CaSDRNIVLYDMRQATPLKK-VILDMRTNTICWNPMEAFIFTAANeDYNLYTFDMRALDTpVMVHMDHVSAVLDVDYSPT 293
Cdd:cd00200   154 S-QDGTIKLWDLRTGKCVATlTGHTGEVNSVAFSPDGEKLLSSSS-DGTIKLWDLSTGKC-LGTLRGHENGVNSVAFSPD 230

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1423310367 294 GKEFVSASFDKSIRIFPVDKSRSREVY--HTKRmqhVICVKWTSDSKYIMCGSDEMNIRLWK 353
Cdd:cd00200   231 GYLLASGSEDGTIRVWDLRTGECVQTLsgHTNS---VTSLAWSPDGKRLASGSADGTIRIWD 289
 
Name Accession Description Interval E-value
Sof1 pfam04158
Sof1-like domain; Sof1 is essential for cell growth and is a component of the nucleolar rRNA ...
 354-435 3.08e-44

Sof1-like domain; Sof1 is essential for cell growth and is a component of the nucleolar rRNA processing machinery.


Pssm-ID: 427753  Cd Length: 87  Bit Score: 149.18  E-value: 3.08e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423310367 354 ANASEKLGVLTSREKAAKDYNQKLKEKFQHYPHIKRIARHRHLPKSIYSQIQEQRIMKEARRRKEVNRIKHSKPGSVPLV 433
Cdd:pfam04158   1 ANASEKLGVLSPRERAALEYNEALKEKYKHMPEIRRIARHRHVPKAIYKAQKIKREMLEARKRKEENRRKHSKPGSVPRK 80


                  ..
gi 1423310367 434 SE 435
Cdd:pfam04158  81 PE 82
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 59-353 5.96e-41

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 147.48  E-value: 5.96e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423310367  59 LASLDGHRDGVNCLAKHPEKlATVLSGACDGEVRIWNLTQRNCIRTIQAHEGFVRGICTRFCGTSFFTVGDDKTVKQWKM 138
Cdd:cd00200     2 RRTLKGHTGGVTCVAFSPDG-KLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423310367 139 DGPgygdeeEPLHTILG--KTVYTgIDHHWKEAVFATCGQQVDIWDEQRTNPICSMTWGF--DSISSVKFNPIETFLLGS 214
Cdd:cd00200    81 ETG------ECVRTLTGhtSYVSS-VAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGhtDWVNSVAFSPDGTFVASS 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423310367 215 CaSDRNIVLYDMRQATPLKK-VILDMRTNTICWNPMEAFIFTAANeDYNLYTFDMRALDTpVMVHMDHVSAVLDVDYSPT 293
Cdd:cd00200   154 S-QDGTIKLWDLRTGKCVATlTGHTGEVNSVAFSPDGEKLLSSSS-DGTIKLWDLSTGKC-LGTLRGHENGVNSVAFSPD 230

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1423310367 294 GKEFVSASFDKSIRIFPVDKSRSREVY--HTKRmqhVICVKWTSDSKYIMCGSDEMNIRLWK 353
Cdd:cd00200   231 GYLLASGSEDGTIRVWDLRTGECVQTLsgHTNS---VTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
46-355 1.89e-29

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 118.86  E-value: 1.89e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423310367  46 NATKLERVFAKPFLASLDGHRDGVNCLAKHPEKlATVLSGACDGEVRIWNLTQRNCIRTIQAHEGFVRGIctRFC--GTS 123
Cdd:COG2319   100 GTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDG-KTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSV--AFSpdGKL 176

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423310367 124 FFTVGDDKTVKQWKMDGPgygdeeEPLHTILGKTVY-TGI----DHHWkeAVFATCGQQVDIWDEQRTNPICSMTWGFDS 198
Cdd:COG2319   177 LASGSDDGTVRLWDLATG------KLLRTLTGHTGAvRSVafspDGKL--LASGSADGTVRLWDLATGKLLRTLTGHSGS 248

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423310367 199 ISSVKFNPIETFLLgSCASDRNIVLYDMRQATPLKKV-ILDMRTNTICWNPMEAFIFTaANEDYNLYTFDMrALDTPVMV 277
Cdd:COG2319   249 VRSVAFSPDGRLLA-SGSADGTVRLWDLATGELLRTLtGHSGGVNSVAFSPDGKLLAS-GSDDGTVRLWDL-ATGKLLRT 325

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423310367 278 HMDHVSAVLDVDYSPTGKEFVSASFDKSIRIFPVDKSRSREVY--HTKRmqhVICVKWTSDSKYIMCGSDEMNIRLWKAN 355
Cdd:COG2319   326 LTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLtgHTGA---VTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 273-309 2.14e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.53  E-value: 2.14e-05
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1423310367  273 TPVMVHMDHVSAVLDVDYSPTGKEFVSASFDKSIRIF 309
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
58-95 4.81e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.41  E-value: 4.81e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1423310367  58 FLASLDGHRDGVNCLAKHPEKlATVLSGACDGEVRIWN 95
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFSPDG-KLLASGSDDGTVKVWD 39
PTZ00420 PTZ00420
coronin; Provisional
 182-268 6.63e-03

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 38.78  E-value: 6.63e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423310367 182 DEQRTNPICSMTWGFDSISSVKFNPIETFLLGSCASDRNIVLYDMRQATPLKKVILD---------MRTNTICWNPMEAF 252
Cdd:PTZ00420   60 NQMRKPPVIKLKGHTSSILDLQFNPCFSEILASGSEDLTIRVWEIPHNDESVKEIKDpqcilkghkKKISIIDWNPMNYY 139

                          90
                  ....*....|....*.
gi 1423310367 253 IFTAANEDYNLYTFDM 268
Cdd:PTZ00420  140 IMCSSGFDSFVNIWDI 155
 
Name Accession Description Interval E-value
Sof1 pfam04158
Sof1-like domain; Sof1 is essential for cell growth and is a component of the nucleolar rRNA ...
 354-435 3.08e-44

Sof1-like domain; Sof1 is essential for cell growth and is a component of the nucleolar rRNA processing machinery.


Pssm-ID: 427753  Cd Length: 87  Bit Score: 149.18  E-value: 3.08e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423310367 354 ANASEKLGVLTSREKAAKDYNQKLKEKFQHYPHIKRIARHRHLPKSIYSQIQEQRIMKEARRRKEVNRIKHSKPGSVPLV 433
Cdd:pfam04158   1 ANASEKLGVLSPRERAALEYNEALKEKYKHMPEIRRIARHRHVPKAIYKAQKIKREMLEARKRKEENRRKHSKPGSVPRK 80


                  ..
gi 1423310367 434 SE 435
Cdd:pfam04158  81 PE 82
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 59-353 5.96e-41

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 147.48  E-value: 5.96e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423310367  59 LASLDGHRDGVNCLAKHPEKlATVLSGACDGEVRIWNLTQRNCIRTIQAHEGFVRGICTRFCGTSFFTVGDDKTVKQWKM 138
Cdd:cd00200     2 RRTLKGHTGGVTCVAFSPDG-KLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423310367 139 DGPgygdeeEPLHTILG--KTVYTgIDHHWKEAVFATCGQQVDIWDEQRTNPICSMTWGF--DSISSVKFNPIETFLLGS 214
Cdd:cd00200    81 ETG------ECVRTLTGhtSYVSS-VAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGhtDWVNSVAFSPDGTFVASS 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423310367 215 CaSDRNIVLYDMRQATPLKK-VILDMRTNTICWNPMEAFIFTAANeDYNLYTFDMRALDTpVMVHMDHVSAVLDVDYSPT 293
Cdd:cd00200   154 S-QDGTIKLWDLRTGKCVATlTGHTGEVNSVAFSPDGEKLLSSSS-DGTIKLWDLSTGKC-LGTLRGHENGVNSVAFSPD 230

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1423310367 294 GKEFVSASFDKSIRIFPVDKSRSREVY--HTKRmqhVICVKWTSDSKYIMCGSDEMNIRLWK 353
Cdd:cd00200   231 GYLLASGSEDGTIRVWDLRTGECVQTLsgHTNS---VTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
46-355 1.89e-29

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 118.86  E-value: 1.89e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423310367  46 NATKLERVFAKPFLASLDGHRDGVNCLAKHPEKlATVLSGACDGEVRIWNLTQRNCIRTIQAHEGFVRGIctRFC--GTS 123
Cdd:COG2319   100 GTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDG-KTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSV--AFSpdGKL 176

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423310367 124 FFTVGDDKTVKQWKMDGPgygdeeEPLHTILGKTVY-TGI----DHHWkeAVFATCGQQVDIWDEQRTNPICSMTWGFDS 198
Cdd:COG2319   177 LASGSDDGTVRLWDLATG------KLLRTLTGHTGAvRSVafspDGKL--LASGSADGTVRLWDLATGKLLRTLTGHSGS 248

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423310367 199 ISSVKFNPIETFLLgSCASDRNIVLYDMRQATPLKKV-ILDMRTNTICWNPMEAFIFTaANEDYNLYTFDMrALDTPVMV 277
Cdd:COG2319   249 VRSVAFSPDGRLLA-SGSADGTVRLWDLATGELLRTLtGHSGGVNSVAFSPDGKLLAS-GSDDGTVRLWDL-ATGKLLRT 325

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423310367 278 HMDHVSAVLDVDYSPTGKEFVSASFDKSIRIFPVDKSRSREVY--HTKRmqhVICVKWTSDSKYIMCGSDEMNIRLWKAN 355
Cdd:COG2319   326 LTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLtgHTGA---VTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 101-364 3.60e-26

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 107.04  E-value: 3.60e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423310367 101 CIRTIQAHEGFVRGICTRFCGTSFFTVGDDKTVKQWKMDGpgygdeEEPLHTILGKT--VYTGIDHHWKEaVFATCG--Q 176
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLET------GELLRTLKGHTgpVRDVAASADGT-YLASGSsdK 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423310367 177 QVDIWDEQRTNPICSMTWGFDSISSVKFNPIETFLLgSCASDRNIVLYDMRQATpLKKVILD--MRTNTICWNPMEAFIF 254
Cdd:cd00200    74 TIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILS-SSSRDKTIKVWDVETGK-CLTTLRGhtDWVNSVAFSPDGTFVA 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423310367 255 TAANEDYnLYTFDMRALdTPVMVHMDHVSAVLDVDYSPTGKEFVSASFDKSIRIFPVDKSRSREVY--HTKRmqhVICVK 332
Cdd:cd00200   152 SSSQDGT-IKLWDLRTG-KCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLrgHENG---VNSVA 226

                         250       260       270
                  ....*....|....*....|....*....|..
gi 1423310367 333 WTSDSKYIMCGSDEMNIRLWKANASEKLGVLT 364
Cdd:cd00200   227 FSPDGYLLASGSEDGTIRVWDLRTGECVQTLS 258
WD40 COG2319
WD40 repeat [General function prediction only];
43-364 1.03e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 102.30  E-value: 1.03e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423310367  43 RALNATKLERVFAKPFLASLDGHRDGVNCLAKHPEKlATVLSGACDGEVRIWNLTQRNCIRTIQAHEGFVRGICTRFCGT 122
Cdd:COG2319    55 AGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDG-RLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGK 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423310367 123 SFFTVGDDKTVKQWKMDGPgygdeeEPLHTILGKTvytgidhHWKEAV--------FATCGQ--QVDIWDEQRTNPICSM 192
Cdd:COG2319   134 TLASGSADGTVRLWDLATG------KLLRTLTGHS-------GAVTSVafspdgklLASGSDdgTVRLWDLATGKLLRTL 200

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423310367 193 TWGFDSISSVKFNPIETFLLgSCASDRNIVLYDMRQATPLKkvILDMRT---NTICWNPmEAFIFTAANEDYNLYTFDmr 269
Cdd:COG2319   201 TGHTGAVRSVAFSPDGKLLA-SGSADGTVRLWDLATGKLLR--TLTGHSgsvRSVAFSP-DGRLLASGSADGTVRLWD-- 274

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423310367 270 aLDTPVMVHM--DHVSAVLDVDYSPTGKEFVSASFDKSIRIFPVDKSRSREVY--HTKRmqhVICVKWTSDSKYIMCGSD 345
Cdd:COG2319   275 -LATGELLRTltGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLtgHTGA---VRSVAFSPDGKTLASGSD 350

                         330
                  ....*....|....*....
gi 1423310367 346 EMNIRLWKANASEKLGVLT 364
Cdd:COG2319   351 DGTVRLWDLATGELLRTLT 369
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 58-309 2.44e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 93.55  E-value: 2.44e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423310367  58 FLASLDGHRDGVNCLAKHPEKLaTVLSGACDGEVRIWNLTQRNCIRTIQAHEGFVRGICTRFCGTSFFTVGDDKTVKQWK 137
Cdd:cd00200   127 CLTTLRGHTDWVNSVAFSPDGT-FVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWD 205

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423310367 138 MDGpgygdeeeplhtilGKTVYTGIDHhwkeavfatcgqqvdiwdeqrTNPICSMTWGFDSissvkfnpietFLLGSCAS 217
Cdd:cd00200   206 LST--------------GKCLGTLRGH---------------------ENGVNSVAFSPDG-----------YLLASGSE 239

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423310367 218 DRNIVLYDMRQATPLKKvildmrtnticwnpmeafiFTAanedynlytfdmraldtpvmvhmdHVSAVLDVDYSPTGKEF 297
Cdd:cd00200   240 DGTIRVWDLRTGECVQT-------------------LSG------------------------HTNSVTSLAWSPDGKRL 276

                         250
                  ....*....|..
gi 1423310367 298 VSASFDKSIRIF 309
Cdd:cd00200   277 ASGSADGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
59-140 2.17e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 65.32  E-value: 2.17e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423310367  59 LASLDGHRDGVNCLAKHPEKlATVLSGACDGEVRIWNLTQRNCIRTIQAHEGFVRGICTRFCGTSFFTVGDDKTVKQWKM 138
Cdd:COG2319   323 LRTLTGHTGAVRSVAFSPDG-KTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDL 401


                  ..
gi 1423310367 139 DG 140
Cdd:COG2319   402 AT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 244-372 3.04e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 60.81  E-value: 3.04e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423310367 244 ICWNPMEAFIFTAAnEDYNLYTFDMrALDTPVMVHMDHVSAVLDVDYSPTGKEFVSASFDKSIRIFPVDKSRSREVY--H 321
Cdd:cd00200    15 VAFSPDGKLLATGS-GDGTIKVWDL-ETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLtgH 92

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1423310367 322 TKRmqhVICVKWTSDSKYIMCGSDEMNIRLWKANASEKLGVLTSREKAAKD 372
Cdd:cd00200    93 TSY---VSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNS 140
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 273-309 2.14e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.53  E-value: 2.14e-05
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1423310367  273 TPVMVHMDHVSAVLDVDYSPTGKEFVSASFDKSIRIF 309
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
CDC55 COG5170
Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms];
199-376 3.73e-05

Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms];


Pssm-ID: 227498 [Multi-domain]  Cd Length: 460  Bit Score: 45.79  E-value: 3.73e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423310367 199 ISSVKFNPIETFLLGSCASDRNIVLYDMRQatplkkvildmrtNTICWNPMEAFIFTAANEDYNLYTfdmraldtpvmvh 278
Cdd:COG5170   224 ITSAEFHPEMCNVFMYSSSKGEIKLNDLRQ-------------SALCDNSKKLFELTIDGVDVDFFE------------- 277

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423310367 279 mDHVSAVLDVDYSPTGKEFVSASFD--------------KSIRIFPVDKSRSREVYHTKRMQHVICVKWTSDSKYIMCGS 344
Cdd:COG5170   278 -EIVSSISDFKFSDNGRYILSRDYLtvkiwdvnmaknpiKTIPMHCDLMDELNDVYENDAIFDKFEISFSGDDKHVLSGS 356

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1423310367 345 DEMNIRLWKANAS---EKLGVLTSREKAAKDYNQK 376
Cdd:COG5170   357 YSNNFGIYPTDSSgfkDVGHVVNLADGSAEDFKVK 391
WD40 pfam00400
WD domain, G-beta repeat;
58-95 4.81e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.41  E-value: 4.81e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1423310367  58 FLASLDGHRDGVNCLAKHPEKlATVLSGACDGEVRIWN 95
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFSPDG-KLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 59-95 1.86e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.83  E-value: 1.86e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1423310367   59 LASLDGHRDGVNCLAKHPEKLaTVLSGACDGEVRIWN 95
Cdd:smart00320   5 LKTLKGHTGPVTSVAFSPDGK-YLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
273-309 4.22e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.71  E-value: 4.22e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1423310367 273 TPVMVHMDHVSAVLDVDYSPTGKEFVSASFDKSIRIF 309
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 98-137 5.32e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.29  E-value: 5.32e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1423310367   98 QRNCIRTIQAHEGFVRGICTRFCGTSFFTVGDDKTVKQWK 137
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
99-136 5.46e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.32  E-value: 5.46e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1423310367  99 RNCIRTIQAHEGFVRGICTRFCGTSFFTVGDDKTVKQW 136
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
PTZ00420 PTZ00420
coronin; Provisional
 182-268 6.63e-03

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 38.78  E-value: 6.63e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1423310367 182 DEQRTNPICSMTWGFDSISSVKFNPIETFLLGSCASDRNIVLYDMRQATPLKKVILD---------MRTNTICWNPMEAF 252
Cdd:PTZ00420   60 NQMRKPPVIKLKGHTSSILDLQFNPCFSEILASGSEDLTIRVWEIPHNDESVKEIKDpqcilkghkKKISIIDWNPMNYY 139

                          90
                  ....*....|....*.
gi 1423310367 253 IFTAANEDYNLYTFDM 268
Cdd:PTZ00420  140 IMCSSGFDSFVNIWDI 155
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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