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Conserved domains on  [gi|68299770|ref|NP_056227|]
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nucleolus and neural progenitor protein isoform a [Homo sapiens]

Protein Classification

nucleolus and neural progenitor protein( domain architecture ID 10632208)

nucleolus and neural progenitor protein (NEPRO) is a DUF4477 domain-containing protein that may play a role in cortex development as part of the Notch signaling pathway

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF4477 pfam14780
Domain of unknown function (DUF4477);
12-202 5.58e-66

Domain of unknown function (DUF4477);


:

Pssm-ID: 464313  Cd Length: 189  Bit Score: 212.86  E-value: 5.58e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68299770    12 WNRVRIPKAGNRSAVTVQnPGAALDLCIAAVIKECHLVILSLKSQTLDAETDVLCAVLYSNHNRMGRHKPHLALKQVEQC 91
Cdd:pfam14780   1 WNRVNLPPPPLVSTVRVP-FKVSTTEFIKAVLKECNTVLKLLSSFVLDTEAALLSRLLYRFKNKFRNHKGFRALKKVNQC 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68299770    92 LKRLKNMNLEGSIQDLFELFSsNENQPLTTKVCVVPSQPVVELVLMKVLGACKLLLRLLDCCCKTFLLTVKHLGLQEFII 171
Cdd:pfam14780  80 LNRLLRMDLERALQDLKSLLP-KKQESIEAGECSLPSQPSLEYVLVRLLGFAKLMLRILDCCKKAFLLSVQHLRLGEFII 158

                         170       180       190
                  ....*....|....*....|....*....|.
gi 68299770   172 LNLVMVGLVSRLWVLYKGVLKRLILLYEPLF 202
Cdd:pfam14780 159 LNVVLLALISRLWVLSRGILKKLCSLYNKLF 189
 
Name Accession Description Interval E-value
DUF4477 pfam14780
Domain of unknown function (DUF4477);
12-202 5.58e-66

Domain of unknown function (DUF4477);


Pssm-ID: 464313  Cd Length: 189  Bit Score: 212.86  E-value: 5.58e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68299770    12 WNRVRIPKAGNRSAVTVQnPGAALDLCIAAVIKECHLVILSLKSQTLDAETDVLCAVLYSNHNRMGRHKPHLALKQVEQC 91
Cdd:pfam14780   1 WNRVNLPPPPLVSTVRVP-FKVSTTEFIKAVLKECNTVLKLLSSFVLDTEAALLSRLLYRFKNKFRNHKGFRALKKVNQC 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68299770    92 LKRLKNMNLEGSIQDLFELFSsNENQPLTTKVCVVPSQPVVELVLMKVLGACKLLLRLLDCCCKTFLLTVKHLGLQEFII 171
Cdd:pfam14780  80 LNRLLRMDLERALQDLKSLLP-KKQESIEAGECSLPSQPSLEYVLVRLLGFAKLMLRILDCCKKAFLLSVQHLRLGEFII 158

                         170       180       190
                  ....*....|....*....|....*....|.
gi 68299770   172 LNLVMVGLVSRLWVLYKGVLKRLILLYEPLF 202
Cdd:pfam14780 159 LNVVLLALISRLWVLSRGILKKLCSLYNKLF 189
 
Name Accession Description Interval E-value
DUF4477 pfam14780
Domain of unknown function (DUF4477);
12-202 5.58e-66

Domain of unknown function (DUF4477);


Pssm-ID: 464313  Cd Length: 189  Bit Score: 212.86  E-value: 5.58e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68299770    12 WNRVRIPKAGNRSAVTVQnPGAALDLCIAAVIKECHLVILSLKSQTLDAETDVLCAVLYSNHNRMGRHKPHLALKQVEQC 91
Cdd:pfam14780   1 WNRVNLPPPPLVSTVRVP-FKVSTTEFIKAVLKECNTVLKLLSSFVLDTEAALLSRLLYRFKNKFRNHKGFRALKKVNQC 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 68299770    92 LKRLKNMNLEGSIQDLFELFSsNENQPLTTKVCVVPSQPVVELVLMKVLGACKLLLRLLDCCCKTFLLTVKHLGLQEFII 171
Cdd:pfam14780  80 LNRLLRMDLERALQDLKSLLP-KKQESIEAGECSLPSQPSLEYVLVRLLGFAKLMLRILDCCKKAFLLSVQHLRLGEFII 158

                         170       180       190
                  ....*....|....*....|....*....|.
gi 68299770   172 LNLVMVGLVSRLWVLYKGVLKRLILLYEPLF 202
Cdd:pfam14780 159 LNVVLLALISRLWVLSRGILKKLCSLYNKLF 189
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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