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Conserved domains on  [gi|21245134|ref|NP_056165|]
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volume-regulated anion channel subunit LRRC8B [Homo sapiens]

Protein Classification

Pannexin_like and LRR domain-containing protein( domain architecture ID 12117038)

Pannexin_like and LRR domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Pannexin_like pfam12534
Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains ...
 1-334 1.74e-180

Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains of metazoan leucine-rich-repeat-containing 8 proteins. These four TMs associate into hexamers resulting in homo- or heteromeric channels that connect the cytosol to the extracellular space. The family is found in association with pfam00560.


:

Pssm-ID: 463622  Cd Length: 345  Bit Score: 520.64  E-value: 1.74e-180
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21245134     1 MITLTELKCLADAQSSYHILKPWWDVFWYYITLIMLLVAVLAGALQLTQSRVLC-----CLPCKVEFDNHCAVPWDILKA 75
Cdd:pfam12534   1 MFPVTELRSFNEQQPAYRILKPWWDVFMDYLSVAMLMIAVFGGTLQLTQDKVVClpcleSPPSTASLDDSYANSLSPTQS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21245134    76 SMNTSSNPGTPLPLPLRIQNDLHRQQYSYIDAVCYEKQLHWFAKFFPYLVLLHTLIFAACSNFWLHYPSTSSRLEHFVAI 155
Cdd:pfam12534  81 APTVSSPSASMIPEPKGRKTNLDRQQYVFINQVCYEKALHWYSKYFPYLVLIHTLIFMVSSNFWFKFPGTSSKIEHFVSI 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21245134   156 LHKCFDSPWTTRALSETVAEQSVRPLKLS-----KSKILLSSSGCSADIDSGKQSLPYPQPGLESAGIE-SPTSSVLDKK 229
Cdd:pfam12534 161 LGKCFDSPWTTRALSETSGEDSEEKKQRLegntvLPKVSSSSSLSSSDESAPLTRTPSVKSSPEKPVVEvPSTVSVLDKK 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21245134   230 EGEQAKAIFEKVKRFRMHVEQKDIIYRVYLKQIIVKVILFVLIITYVPYFLTHITLEIDCSVDVQAFTGYKRYQCVYSLA 309
Cdd:pfam12534 241 EGEQAKALFEKVKKFRAHVEESDIIYKMYVAQTVLKVLKFLLILSYTSYLVSNISFTVDCKPDIEALTGYSRFYCNHNLA 320

                         330       340
                  ....*....|....*....|....*
gi 21245134   310 EIFKVLASFYVILVILYGLTSSYSL 334
Cdd:pfam12534 321 FLFSKLLVFYISLVGVYGLLCLYTL 345
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
511-789 4.23e-33

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 132.75  E-value: 4.23e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21245134 511 NLKELYLSGCVLPEQLSTMQLEGFQDLKNLRTLYLKSSLSRIPQVVTDLLPSLQKLSLDNEGSKLVVLNNLKKMVNLKSL 590
Cdd:COG4886   1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21245134 591 ELISCDLerIPHSIFSLNNLHELDLRENNlktveeiiSFQHLQNLSCLKLWHNNIAYIPAQIGALSNLEQLSLDHNNIEN 670
Cdd:COG4886  81 LLSLLLL--GLTDLGDLTNLTELDLSGNE--------ELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTD 150

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21245134 671 LPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYFAVTNNNIEMLPDGLFQCKKLQCLLLGKNSLMNLSPHVGELSNL 750
Cdd:COG4886 151 LPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNL 230

                       250       260       270
                ....*....|....*....|....*....|....*....
gi 21245134 751 THLELIGNYLETLpPELEGCQSLKRncLIVEENLLNTLP 789
Cdd:COG4886 231 ETLDLSNNQLTDL-PELGNLTNLEE--LDLSNNQLTDLP 266
 
Name Accession Description Interval E-value
Pannexin_like pfam12534
Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains ...
 1-334 1.74e-180

Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains of metazoan leucine-rich-repeat-containing 8 proteins. These four TMs associate into hexamers resulting in homo- or heteromeric channels that connect the cytosol to the extracellular space. The family is found in association with pfam00560.


Pssm-ID: 463622  Cd Length: 345  Bit Score: 520.64  E-value: 1.74e-180
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21245134     1 MITLTELKCLADAQSSYHILKPWWDVFWYYITLIMLLVAVLAGALQLTQSRVLC-----CLPCKVEFDNHCAVPWDILKA 75
Cdd:pfam12534   1 MFPVTELRSFNEQQPAYRILKPWWDVFMDYLSVAMLMIAVFGGTLQLTQDKVVClpcleSPPSTASLDDSYANSLSPTQS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21245134    76 SMNTSSNPGTPLPLPLRIQNDLHRQQYSYIDAVCYEKQLHWFAKFFPYLVLLHTLIFAACSNFWLHYPSTSSRLEHFVAI 155
Cdd:pfam12534  81 APTVSSPSASMIPEPKGRKTNLDRQQYVFINQVCYEKALHWYSKYFPYLVLIHTLIFMVSSNFWFKFPGTSSKIEHFVSI 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21245134   156 LHKCFDSPWTTRALSETVAEQSVRPLKLS-----KSKILLSSSGCSADIDSGKQSLPYPQPGLESAGIE-SPTSSVLDKK 229
Cdd:pfam12534 161 LGKCFDSPWTTRALSETSGEDSEEKKQRLegntvLPKVSSSSSLSSSDESAPLTRTPSVKSSPEKPVVEvPSTVSVLDKK 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21245134   230 EGEQAKAIFEKVKRFRMHVEQKDIIYRVYLKQIIVKVILFVLIITYVPYFLTHITLEIDCSVDVQAFTGYKRYQCVYSLA 309
Cdd:pfam12534 241 EGEQAKALFEKVKKFRAHVEESDIIYKMYVAQTVLKVLKFLLILSYTSYLVSNISFTVDCKPDIEALTGYSRFYCNHNLA 320

                         330       340
                  ....*....|....*....|....*
gi 21245134   310 EIFKVLASFYVILVILYGLTSSYSL 334
Cdd:pfam12534 321 FLFSKLLVFYISLVGVYGLLCLYTL 345
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
511-789 4.23e-33

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 132.75  E-value: 4.23e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21245134 511 NLKELYLSGCVLPEQLSTMQLEGFQDLKNLRTLYLKSSLSRIPQVVTDLLPSLQKLSLDNEGSKLVVLNNLKKMVNLKSL 590
Cdd:COG4886   1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21245134 591 ELISCDLerIPHSIFSLNNLHELDLRENNlktveeiiSFQHLQNLSCLKLWHNNIAYIPAQIGALSNLEQLSLDHNNIEN 670
Cdd:COG4886  81 LLSLLLL--GLTDLGDLTNLTELDLSGNE--------ELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTD 150

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21245134 671 LPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYFAVTNNNIEMLPDGLFQCKKLQCLLLGKNSLMNLSPHVGELSNL 750
Cdd:COG4886 151 LPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNL 230

                       250       260       270
                ....*....|....*....|....*....|....*....
gi 21245134 751 THLELIGNYLETLpPELEGCQSLKRncLIVEENLLNTLP 789
Cdd:COG4886 231 ETLDLSNNQLTDL-PELGNLTNLEE--LDLSNNQLTDLP 266
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
578-797 2.93e-13

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 73.58  E-value: 2.93e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21245134  578 LNNLKKMVNLKSLELIScdlerIPHSIfsLNNLHELDLRENNLKTVEEiisfqHLQ-NLSCLKLWHNNIAYIPAQIGalS 656
Cdd:PRK15370 176 LKNNKTELRLKILGLTT-----IPACI--PEQITTLILDNNELKSLPE-----NLQgNIKTLYANSNQLTSIPATLP--D 241

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21245134  657 NLEQLSLDHNNIENLPLQLflCTKLHYLDLSYNHLTFIPEEIQylSNLQYFAVTNNNIEMLPDGLfqckklqclllgkns 736
Cdd:PRK15370 242 TIQEMELSINRITELPERL--PSALQSLDLFHNKISCLPENLP--EELRYLSVYDNSIRTLPAHL--------------- 302

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 21245134  737 lmnlsPhvgelSNLTHLELIGNYL----ETLPPELEgcqslkrnCLIVEENLLNTLPLPVTERLQ 797
Cdd:PRK15370 303 -----P-----SGITHLNVQSNSLtalpETLPPGLK--------TLEAGENALTSLPASLPPELQ 349
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 609-758 2.67e-11

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 64.04  E-value: 2.67e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21245134 609 NLHELDLRENNLKTVEeiiSFQHLQNLSCLKLWHNNIAYIPaQIGALSNLEQLSLDHNNI---ENLPLqlflCTKLHYLD 685
Cdd:cd21340  25 NLKVLYLYDNKITKIE---NLEFLTNLTHLYLQNNQIEKIE-NLENLVNLKKLYLGGNRIsvvEGLEN----LTNLEELH 96

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21245134 686 LSYNHL------TFIPEEIQYLSN-LQYFAVTNNNIEMLpDGLFQCKKLQCLLLGKNSLMN---LSPHVGELSNLTHLEL 755
Cdd:cd21340  97 IENQRLppgeklTFDPRSLAALSNsLRVLNISGNNIDSL-EPLAPLRNLEQLDASNNQISDleeLLDLLSSWPSLRELDL 175


                ...
gi 21245134 756 IGN 758
Cdd:cd21340 176 TGN 178
LRR_8 pfam13855
Leucine rich repeat;
633-691 2.90e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.43  E-value: 2.90e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 21245134   633 QNLSCLKLWHNNIAYI-PAQIGALSNLEQLSLDHNNIENLPLQLFLC-TKLHYLDLSYNHL 691
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGlPSLRYLDLSGNRL 61
 
Name Accession Description Interval E-value
Pannexin_like pfam12534
Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains ...
 1-334 1.74e-180

Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains of metazoan leucine-rich-repeat-containing 8 proteins. These four TMs associate into hexamers resulting in homo- or heteromeric channels that connect the cytosol to the extracellular space. The family is found in association with pfam00560.


Pssm-ID: 463622  Cd Length: 345  Bit Score: 520.64  E-value: 1.74e-180
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21245134     1 MITLTELKCLADAQSSYHILKPWWDVFWYYITLIMLLVAVLAGALQLTQSRVLC-----CLPCKVEFDNHCAVPWDILKA 75
Cdd:pfam12534   1 MFPVTELRSFNEQQPAYRILKPWWDVFMDYLSVAMLMIAVFGGTLQLTQDKVVClpcleSPPSTASLDDSYANSLSPTQS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21245134    76 SMNTSSNPGTPLPLPLRIQNDLHRQQYSYIDAVCYEKQLHWFAKFFPYLVLLHTLIFAACSNFWLHYPSTSSRLEHFVAI 155
Cdd:pfam12534  81 APTVSSPSASMIPEPKGRKTNLDRQQYVFINQVCYEKALHWYSKYFPYLVLIHTLIFMVSSNFWFKFPGTSSKIEHFVSI 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21245134   156 LHKCFDSPWTTRALSETVAEQSVRPLKLS-----KSKILLSSSGCSADIDSGKQSLPYPQPGLESAGIE-SPTSSVLDKK 229
Cdd:pfam12534 161 LGKCFDSPWTTRALSETSGEDSEEKKQRLegntvLPKVSSSSSLSSSDESAPLTRTPSVKSSPEKPVVEvPSTVSVLDKK 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21245134   230 EGEQAKAIFEKVKRFRMHVEQKDIIYRVYLKQIIVKVILFVLIITYVPYFLTHITLEIDCSVDVQAFTGYKRYQCVYSLA 309
Cdd:pfam12534 241 EGEQAKALFEKVKKFRAHVEESDIIYKMYVAQTVLKVLKFLLILSYTSYLVSNISFTVDCKPDIEALTGYSRFYCNHNLA 320

                         330       340
                  ....*....|....*....|....*
gi 21245134   310 EIFKVLASFYVILVILYGLTSSYSL 334
Cdd:pfam12534 321 FLFSKLLVFYISLVGVYGLLCLYTL 345
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
511-789 4.23e-33

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 132.75  E-value: 4.23e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21245134 511 NLKELYLSGCVLPEQLSTMQLEGFQDLKNLRTLYLKSSLSRIPQVVTDLLPSLQKLSLDNEGSKLVVLNNLKKMVNLKSL 590
Cdd:COG4886   1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21245134 591 ELISCDLerIPHSIFSLNNLHELDLRENNlktveeiiSFQHLQNLSCLKLWHNNIAYIPAQIGALSNLEQLSLDHNNIEN 670
Cdd:COG4886  81 LLSLLLL--GLTDLGDLTNLTELDLSGNE--------ELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTD 150

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21245134 671 LPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYFAVTNNNIEMLPDGLFQCKKLQCLLLGKNSLMNLSPHVGELSNL 750
Cdd:COG4886 151 LPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNL 230

                       250       260       270
                ....*....|....*....|....*....|....*....
gi 21245134 751 THLELIGNYLETLpPELEGCQSLKRncLIVEENLLNTLP 789
Cdd:COG4886 231 ETLDLSNNQLTDL-PELGNLTNLEE--LDLSNNQLTDLP 266
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
507-797 6.46e-33

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 131.98  E-value: 6.46e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21245134 507 FHLKNLKELYLSGCVLPEQLSTMQLEGFQDLKNLRTLYLKSSLSRIPQV--VTDLLPSLQKLSLDNEGSKLVVLNNLKKM 584
Cdd:COG4886  16 LLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSllLLLSLLLLLLLSLLLLSLLLLGLTDLGDL 95

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21245134 585 VNLKSLELISCDleriphSIFSLNNLHELDLRENNLKTVEEIISfqHLQNLSCLKLWHNNIAYIPAQIGALSNLEQLSLD 664
Cdd:COG4886  96 TNLTELDLSGNE------ELSNLTNLESLDLSGNQLTDLPEELA--NLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLS 167

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21245134 665 HNNIENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYFAVTNNNIEMLPDGLFQCKKLQCLLLGKNSLMNLsPHV 744
Cdd:COG4886 168 NNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDL-PEL 246

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 21245134 745 GELSNLTHLELIGNYLETLPPELEgCQSLKRncLIVEENLLNTLPLPVTERLQ 797
Cdd:COG4886 247 GNLTNLEELDLSNNQLTDLPPLAN-LTNLKT--LDLSNNQLTDLKLKELELLL 296
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
394-798 7.34e-24

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 105.02  E-value: 7.34e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21245134 394 NKLKQINLNNEWTVEKLKSKLVKNAQDKIELHLFMLNGLPDNVFELTEMEVLSLELIPEVKLPSAVSQLVNLKELRvyhs 473
Cdd:COG4886  24 LILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLT---- 99

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21245134 474 SLVVDHPALAFLEENLKILRLKFTEMGKIPRWVFHLKNLKELYLSGCvlpeQLSTMQlEGFQDLKNLRTLYLKS-SLSRI 552
Cdd:COG4886 100 ELDLSGNEELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNN----QLTDLP-EPLGNLTNLKSLDLSNnQLTDL 174

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21245134 553 PqvvtdllpslqklsldnegsklvvlNNLKKMVNLKSLELISCDLERIPHSIFSLNNLHELDLRENNLKTVEEiiSFQHL 632
Cdd:COG4886 175 P-------------------------EELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPE--PLANL 227

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21245134 633 QNLSCLKLWHNNIAYIPaQIGALSNLEQLSLDHNNIENLPLQLFLcTKLHYLDLSYNHLTFIPEEIQYLSNLQYFAVTNN 712
Cdd:COG4886 228 TNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLTDLPPLANL-TNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLL 305

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21245134 713 NIEMLPDGLFQCKKLQCLLLGKNSLMNLSPHVGELSNLTHLELIGNYLETLPPELEGCQSLKRNCLIVEENLLNTLPLPV 792
Cdd:COG4886 306 LLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALL 385


                ....*.
gi 21245134 793 TERLQT 798
Cdd:COG4886 386 LLTLLL 391
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
338-742 4.38e-20

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 93.46  E-value: 4.38e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21245134 338 LRSSLKQYSFEALREKSNYSDIPDVKNDFAFILHLADQYDPLYSKRFSIFLSEVSENKLKQINLNNEWTVEKLKSKLVKN 417
Cdd:COG4886  12 LLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTD 91

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21245134 418 AQDKIELHLFMLNGlPDNVFELTEMEVLSLELIPEVKLPSAVSQLVNLKELRVYHSSLVVDHPALAFLEeNLKILRLKFT 497
Cdd:COG4886  92 LGDLTNLTELDLSG-NEELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLT-NLKSLDLSNN 169

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21245134 498 EMGKIPRWVFHLKNLKELYLSGCvlpeQLSTMQLEgFQDLKNLRTLYL-KSSLSRIPQVVTDlLPSLQKLSLDNegSKLV 576
Cdd:COG4886 170 QLTDLPEELGNLTNLKELDLSNN----QITDLPEP-LGNLTNLEELDLsGNQLTDLPEPLAN-LTNLETLDLSN--NQLT 241

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21245134 577 VLNNLKKMVNLKSLELISCDLERIPHSiFSLNNLHELDLRENNLKT--VEEIISFQHLQNLSCLKLWHNNIAYIPAQIGA 654
Cdd:COG4886 242 DLPELGNLTNLEELDLSNNQLTDLPPL-ANLTNLKTLDLSNNQLTDlkLKELELLLGLNSLLLLLLLLNLLELLILLLLL 320

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21245134 655 LSNLEQLSLDHNN---IENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYFAVTNNNIEMLPDGLFQCKKLQCLL 731
Cdd:COG4886 321 TTLLLLLLLLKGLlvtLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGV 400

                       410
                ....*....|.
gi 21245134 732 LGKNSLMNLSP 742
Cdd:COG4886 401 LLLTLALLDAV 411
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
578-797 2.93e-13

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 73.58  E-value: 2.93e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21245134  578 LNNLKKMVNLKSLELIScdlerIPHSIfsLNNLHELDLRENNLKTVEEiisfqHLQ-NLSCLKLWHNNIAYIPAQIGalS 656
Cdd:PRK15370 176 LKNNKTELRLKILGLTT-----IPACI--PEQITTLILDNNELKSLPE-----NLQgNIKTLYANSNQLTSIPATLP--D 241

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21245134  657 NLEQLSLDHNNIENLPLQLflCTKLHYLDLSYNHLTFIPEEIQylSNLQYFAVTNNNIEMLPDGLfqckklqclllgkns 736
Cdd:PRK15370 242 TIQEMELSINRITELPERL--PSALQSLDLFHNKISCLPENLP--EELRYLSVYDNSIRTLPAHL--------------- 302

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 21245134  737 lmnlsPhvgelSNLTHLELIGNYL----ETLPPELEgcqslkrnCLIVEENLLNTLPLPVTERLQ 797
Cdd:PRK15370 303 -----P-----SGITHLNVQSNSLtalpETLPPGLK--------TLEAGENALTSLPASLPPELQ 349
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 455-773 9.29e-13

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 72.19  E-value: 9.29e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21245134  455 LPSAVSQLVNLKELRVYHSSLVVDHPALAFLEENLKILRL---KFTemGKIPRWVFHLKNLKELYLSGCVLPEQLSTMQL 531
Cdd:PLN00113 228 IPYEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLyqnKLS--GPIPPSIFSLQKLISLDLSDNSLSGEIPELVI 305

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21245134  532 EgfqdLKNLRTLYLKSS--LSRIPQVVTDLlPSLQKLSL-DNEGS-----------KLVVL----NNLKKMV-------- 585
Cdd:PLN00113 306 Q----LQNLEILHLFSNnfTGKIPVALTSL-PRLQVLQLwSNKFSgeipknlgkhnNLTVLdlstNNLTGEIpeglcssg 380

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21245134  586 NLKSLELISCDLE-RIPHSIFSLNNLHELDLRENNLkTVEEIISFQHLQNLSCLKLWHNNI-AYIPAQIGALSNLEQLSL 663
Cdd:PLN00113 381 NLFKLILFSNSLEgEIPKSLGACRSLRRVRLQDNSF-SGELPSEFTKLPLVYFLDISNNNLqGRINSRKWDMPSLQMLSL 459

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21245134  664 DHNNIE-NLPlQLFLCTKLHYLDLSYNHLT-FIPEEIQYLSNLQYFAVTNNNIE-MLPDGLFQCKKLQCLLLGKNSLMNL 740
Cdd:PLN00113 460 ARNKFFgGLP-DSFGSKRLENLDLSRNQFSgAVPRKLGSLSELMQLKLSENKLSgEIPDELSSCKKLVSLDLSHNQLSGQ 538

                        330       340       350
                 ....*....|....*....|....*....|....*
gi 21245134  741 SP-HVGELSNLTHLELIGNYLE-TLPPELEGCQSL 773
Cdd:PLN00113 539 IPaSFSEMPVLSQLDLSQNQLSgEIPKNLGNVESL 573
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 500-775 2.44e-12

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 70.65  E-value: 2.44e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21245134  500 GKIPRWVFHL-KNLKELYLSGcvlpEQLSTMQLEGFqdLKNLRTLYLKSSL--SRIPQVVtDLLPSLQKLSLDneGSKLV 576
Cdd:PLN00113 107 GPIPDDIFTTsSSLRYLNLSN----NNFTGSIPRGS--IPNLETLDLSNNMlsGEIPNDI-GSFSSLKVLDLG--GNVLV 177

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21245134  577 --VLNNLKKMVNLKSLELISCDLE-RIPHSIFSLNNLHELDLRENNLkTVEEIISFQHLQNLSCLKLWHNNIA-YIPAQI 652
Cdd:PLN00113 178 gkIPNSLTNLTSLEFLTLASNQLVgQIPRELGQMKSLKWIYLGYNNL-SGEIPYEIGGLTSLNHLDLVYNNLTgPIPSSL 256

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21245134  653 GALSNLEQLSLDHNNIEN-LPLQLFLCTKLHYLDLSYNHLTF-IPEEIQYLSNLQYFAVTNNNIE-MLPDGLFQCKKLQC 729
Cdd:PLN00113 257 GNLKNLQYLFLYQNKLSGpIPPSIFSLQKLISLDLSDNSLSGeIPELVIQLQNLEILHLFSNNFTgKIPVALTSLPRLQV 336

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 21245134  730 LLLGKNSL-----MNLSPH----VGELS----------------NLTHLELIGNYLET-LPPELEGCQSLKR 775
Cdd:PLN00113 337 LQLWSNKFsgeipKNLGKHnnltVLDLStnnltgeipeglcssgNLFKLILFSNSLEGeIPKSLGACRSLRR 408
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 488-769 2.48e-12

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 70.65  E-value: 2.48e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21245134  488 NLKILRLKFTE-MGKIPRWVFHLKNLKELYLSGCVL----PEQLSTMqlegfqdlKNLRTLYLK-SSLS-RIPQVVTDLL 560
Cdd:PLN00113 165 SLKVLDLGGNVlVGKIPNSLTNLTSLEFLTLASNQLvgqiPRELGQM--------KSLKWIYLGyNNLSgEIPYEIGGLT 236

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21245134  561 pSLQKLSL---DNEGSKLVVLNNLKkmvNLKSLELISCDLE-RIPHSIFSLNNLHELDLRENNLK-TVEEIISfqHLQNL 635
Cdd:PLN00113 237 -SLNHLDLvynNLTGPIPSSLGNLK---NLQYLFLYQNKLSgPIPPSIFSLQKLISLDLSDNSLSgEIPELVI--QLQNL 310

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21245134  636 SCLKLWHNNI-AYIPAQIGALSNLEQLSLDHNNIE-NLPLQLFLCTKLHYLDLSYNHLT-FIPEEIQYLSNLQYFAVTNN 712
Cdd:PLN00113 311 EILHLFSNNFtGKIPVALTSLPRLQVLQLWSNKFSgEIPKNLGKHNNLTVLDLSTNNLTgEIPEGLCSSGNLFKLILFSN 390

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 21245134  713 NIE-MLPDGLFQCKKLQCLLLGKNSLMnlsphvGELSN-LTHLELIgNYLETLPPELEG 769
Cdd:PLN00113 391 SLEgEIPKSLGACRSLRRVRLQDNSFS------GELPSeFTKLPLV-YFLDISNNNLQG 442
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 609-758 2.67e-11

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 64.04  E-value: 2.67e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21245134 609 NLHELDLRENNLKTVEeiiSFQHLQNLSCLKLWHNNIAYIPaQIGALSNLEQLSLDHNNI---ENLPLqlflCTKLHYLD 685
Cdd:cd21340  25 NLKVLYLYDNKITKIE---NLEFLTNLTHLYLQNNQIEKIE-NLENLVNLKKLYLGGNRIsvvEGLEN----LTNLEELH 96

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21245134 686 LSYNHL------TFIPEEIQYLSN-LQYFAVTNNNIEMLpDGLFQCKKLQCLLLGKNSLMN---LSPHVGELSNLTHLEL 755
Cdd:cd21340  97 IENQRLppgeklTFDPRSLAALSNsLRVLNISGNNIDSL-EPLAPLRNLEQLDASNNQISDleeLLDLLSSWPSLRELDL 175


                ...
gi 21245134 756 IGN 758
Cdd:cd21340 176 TGN 178
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
485-698 5.00e-08

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 56.63  E-value: 5.00e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21245134  485 LEENLKILRLKFTEMGKIPRWVfhlknlkelylsgcvlPEQLSTMQLEGfQDLK--------NLRTLYLKSS-LSRIPQV 555
Cdd:PRK15370 176 LKNNKTELRLKILGLTTIPACI----------------PEQITTLILDN-NELKslpenlqgNIKTLYANSNqLTSIPAT 238

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21245134  556 VTDL-----------------LPS-LQklSLDNEGSKLVVL-NNLKKmvNLKSLELISCDL----ERIPHSIFSLN---- 608
Cdd:PRK15370 239 LPDTiqemelsinritelperLPSaLQ--SLDLFHNKISCLpENLPE--ELRYLSVYDNSIrtlpAHLPSGITHLNvqsn 314

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21245134  609 -----------NLHELDLRENNLKTVEEIISfQHLQNLSCLKlwhNNIAYIPAQIGalSNLEQLSLDHNNIENLPLQLfl 677
Cdd:PRK15370 315 sltalpetlppGLKTLEAGENALTSLPASLP-PELQVLDVSK---NQITVLPETLP--PTITTLDVSRNALTNLPENL-- 386

                        250       260
                 ....*....|....*....|.
gi 21245134  678 CTKLHYLDLSYNHLTFIPEEI 698
Cdd:PRK15370 387 PAALQIMQASRNNLVRLPESL 407
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 509-692 6.14e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 54.02  E-value: 6.14e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21245134 509 LKNLKELYLSGCVLPEqlstmqLEGFQDLKNLRTLYLKS-SLSRIPQVvtDLLPSLQKLSLDNegSKLVVLNNLKKMVNL 587
Cdd:cd21340   1 LKRITHLYLNDKNITK------IDNLSLCKNLKVLYLYDnKITKIENL--EFLTNLTHLYLQN--NQIEKIENLENLVNL 70

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21245134 588 KSLEL----ISC--DLEriphsifSLNNLHELDLRENNLKTVEEII----SFQHLQN-LSCLKLWHNNIAYIpAQIGALS 656
Cdd:cd21340  71 KKLYLggnrISVveGLE-------NLTNLEELHIENQRLPPGEKLTfdprSLAALSNsLRVLNISGNNIDSL-EPLAPLR 142

                       170       180       190
                ....*....|....*....|....*....|....*....
gi 21245134 657 NLEQLSLDHNNIENL-PLQLFL--CTKLHYLDLSYNHLT 692
Cdd:cd21340 143 NLEQLDASNNQISDLeELLDLLssWPSLRELDLTGNPVC 181
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 428-704 7.83e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 56.01  E-value: 7.83e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21245134  428 MLNG-LPDNVFELTEMevLSLELIPEV---KLPSAVSQLVNLKELRVYHSSLVVDHP-ALAFLEEnLKILRL---KFTem 499
Cdd:PLN00113 271 KLSGpIPPSIFSLQKL--ISLDLSDNSlsgEIPELVIQLQNLEILHLFSNNFTGKIPvALTSLPR-LQVLQLwsnKFS-- 345

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21245134  500 GKIPRWVFHLKNLKELYLSGCVLPEQLStmqlEGFQDLKNLRTLYLKS-SL-SRIPQVVTDLlPSLQKLSLDNEGSKLVV 577
Cdd:PLN00113 346 GEIPKNLGKHNNLTVLDLSTNNLTGEIP----EGLCSSGNLFKLILFSnSLeGEIPKSLGAC-RSLRRVRLQDNSFSGEL 420

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21245134  578 LNNLKKMVNLKSLELISCDLE-RIPHSIFSLNNLHELDLRENNLktVEEIISFQHLQNLSCLKLWHNNIA-YIPAQIGAL 655
Cdd:PLN00113 421 PSEFTKLPLVYFLDISNNNLQgRINSRKWDMPSLQMLSLARNKF--FGGLPDSFGSKRLENLDLSRNQFSgAVPRKLGSL 498

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 21245134  656 SNLEQLSLDHNNIEN-LPLQLFLCTKLHYLDLSYNHLT-FIP---EEIQYLSNL 704
Cdd:PLN00113 499 SELMQLKLSENKLSGeIPDELSSCKKLVSLDLSHNQLSgQIPasfSEMPVLSQL 552
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 530-784 5.74e-06

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 49.40  E-value: 5.74e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21245134 530 QLEGFQDLKNLRTLYLKSSLSRIPQVVTDLLPSL--QKLSLDNEGS-KLVVLNNLKKMVNLKSLELISCDLERIPHSIFS 606
Cdd:COG5238 127 LEDSLILYLALPRRINLIQVLKDPLGGNAVHLLGlaARLGLLAAISmAKALQNNSVETVYLGCNQIGDEGIEELAEALTQ 206

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21245134 607 LNNLHELDLRENNL--KTVEEIIS-FQHLQNLSCLKLWHNNI--AYIPAQIGAL---SNLEQLSLDHNNIEN-----LPL 673
Cdd:COG5238 207 NTTVTTLWLKRNPIgdEGAEILAEaLKGNKSLTTLDLSNNQIgdEGVIALAEALknnTTVETLYLSGNQIGAegaiaLAK 286

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21245134 674 QLFLCTKLHYLDLSYNHLTFipeeiqylsnlqyfavtnNNIEMLPDGLFQCKKLQCLLLGKNSLMN-----LSPHVGELS 748
Cdd:COG5238 287 ALQGNTTLTSLDLSVNRIGD------------------EGAIALAEGLQGNKTLHTLNLAYNGIGAqgaiaLAKALQENT 348

                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 21245134 749 NLTHLELIGNYLETlppelEG----CQSLKRNCLIVEENL 784
Cdd:COG5238 349 TLHSLDLSDNQIGD-----EGaialAKYLEGNTTLRELNL 383
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 510-692 5.66e-05

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 45.81  E-value: 5.66e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21245134 510 KNLKELYLSGCVLPEQLSTMQ--LEGFQDLKNLRTLYLK--SSLSRIPQVVTDLL--PSLQKLSLDNEGsklvvLNNLKK 583
Cdd:cd00116  51 PSLKELCLSLNETGRIPRGLQslLQGLTKGCGLQELDLSdnALGPDGCGVLESLLrsSSLQELKLNNNG-----LGDRGL 125

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21245134 584 MVNLKSLELISCDLERIPHSIFSLNN---------------LHELDLRENNLkTVEEIIS----FQHLQNLSCLKLWHN- 643
Cdd:cd00116 126 RLLAKGLKDLPPALEKLVLGRNRLEGascealakalranrdLKELNLANNGI-GDAGIRAlaegLKANCNLEVLDLNNNg 204

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 21245134 644 ----NIAYIPAQIGALSNLEQLSLDHNNIENLPLQ------LFLCTKLHYLDLSYNHLT 692
Cdd:cd00116 205 ltdeGASALAETLASLKSLEVLNLGDNNLTDAGAAalasalLSPNISLLTLSLSCNDIT 263
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 433-705 5.85e-05

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 46.79  E-value: 5.85e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21245134   433 PDNVFELtEMEVLSLElipevKLPSAVSQLVNLKELRVYHSSLVVDHPALAfLEENLKILRL-KFTEMGKIPRWVFHLKN 511
Cdd:PLN03210  610 PENLVKL-QMQGSKLE-----KLWDGVHSLTGLRNIDLRGSKNLKEIPDLS-MATNLETLKLsDCSSLVELPSSIQYLNK 682

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21245134   512 LKELYLSGC----VLP-----EQLSTMQLEGFQDLK-------NLRTLYL-KSSLSRIPqvvTDL-LPSLQKLSL-DNEG 572
Cdd:PLN03210  683 LEDLDMSRCenleILPtginlKSLYRLNLSGCSRLKsfpdistNISWLDLdETAIEEFP---SNLrLENLDELILcEMKS 759

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21245134   573 SKLV----VLNNLKKMVNLKSLELISCD---LERIPHSIFSLNNLHELDLRE-NNLKTVEEIISFQHLQNLS---CLKL- 640
Cdd:PLN03210  760 EKLWervqPLTPLMTMLSPSLTRLFLSDipsLVELPSSIQNLHKLEHLEIENcINLETLPTGINLESLESLDlsgCSRLr 839

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 21245134   641 WHNNIAyipaqigalSNLEQLSLDHNNIENLPLQLFLCTKLHYLDLS-YNHLTFIPEEIQYLSNLQ 705
Cdd:PLN03210  840 TFPDIS---------TNISDLNLSRTGIEEVPWWIEKFSNLSFLDMNgCNNLQRVSLNISKLKHLE 896
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 432-666 7.00e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 46.38  E-value: 7.00e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21245134  432 LPDNVFELTEMEVLSL---ELIPevKLPSAVSQLVNLKELRVYHSSLVVDHPALAFLEENLKILRLKFTEM-GKIPRWVF 507
Cdd:PLN00113 300 IPELVIQLQNLEILHLfsnNFTG--KIPVALTSLPRLQVLQLWSNKFSGEIPKNLGKHNNLTVLDLSTNNLtGEIPEGLC 377

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21245134  508 HLKNLKELYLSGCVL----PEQLSTMQ-LEGFQDLKNLRTLYLKSSLSRIPQV-VTDL---------------LPSLQKL 566
Cdd:PLN00113 378 SSGNLFKLILFSNSLegeiPKSLGACRsLRRVRLQDNSFSGELPSEFTKLPLVyFLDIsnnnlqgrinsrkwdMPSLQML 457

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21245134  567 SL----------DNEGSKlvVLNNLKKMVNLKS----------LELISCDLER------IPHSIFSLNNLHELDLRENNL 620
Cdd:PLN00113 458 SLarnkffgglpDSFGSK--RLENLDLSRNQFSgavprklgslSELMQLKLSEnklsgeIPDELSSCKKLVSLDLSHNQL 535

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*..
gi 21245134  621 kTVEEIISFQHLQNLSCLKLWHNNIA-YIPAQIGALSNLEQLSLDHN 666
Cdd:PLN00113 536 -SGQIPASFSEMPVLSQLDLSQNQLSgEIPKNLGNVESLVQVNISHN 581
LRR_8 pfam13855
Leucine rich repeat;
633-691 2.90e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.43  E-value: 2.90e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 21245134   633 QNLSCLKLWHNNIAYI-PAQIGALSNLEQLSLDHNNIENLPLQLFLC-TKLHYLDLSYNHL 691
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGlPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 711-784 3.94e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 42.47  E-value: 3.94e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 21245134 711 NNNIEMLPDgLFQCKKLQCLLLGKNSLMNLsPHVGELSNLTHLELIGNYLETLPPeLEGCQSLK-----RNCLIVEENL 784
Cdd:cd21340  11 DKNITKIDN-LSLCKNLKVLYLYDNKITKI-ENLEFLTNLTHLYLQNNQIEKIEN-LENLVNLKklylgGNRISVVEGL 86
LRR_8 pfam13855
Leucine rich repeat;
586-645 4.51e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.04  E-value: 4.51e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 21245134   586 NLKSLELISCDLERIPHSIFS-LNNLHELDLRENNLKTVEEiISFQHLQNLSCLKLWHNNI 645
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKgLSNLKVLDLSNNLLTTLSP-GAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
679-737 1.94e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.12  E-value: 1.94e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 21245134   679 TKLHYLDLSYNHLTFIPEEI-QYLSNLQYFAVTNNNIEMLPDGLFQC-KKLQCLLLGKNSL 737
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLSPGAFSGlPSLRYLDLSGNRL 61
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 586-774 2.75e-03

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 41.40  E-value: 2.75e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21245134   586 NLKSLELISCDLERIPHSIFSLNNLHELDLR-ENNLKtveEIISFQHLQNLSCLKLWH-NNIAYIPAQIGALSNLEQLSL 663
Cdd:PLN03210  612 NLVKLQMQGSKLEKLWDGVHSLTGLRNIDLRgSKNLK---EIPDLSMATNLETLKLSDcSSLVELPSSIQYLNKLEDLDM 688

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21245134   664 DH-NNIENLP----------LQLFLCTKLH----------YLDLSYNHLTFIPEEIQyLSNLQYFAVTNNNIEML----- 717
Cdd:PLN03210  689 SRcENLEILPtginlkslyrLNLSGCSRLKsfpdistnisWLDLDETAIEEFPSNLR-LENLDELILCEMKSEKLwervq 767

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 21245134   718 ---PDGLFQCKKLQCLLLGKN-SLMNLSPHVGELSNLTHLELIG-NYLETLPP----------ELEGCQSLK 774
Cdd:PLN03210  768 pltPLMTMLSPSLTRLFLSDIpSLVELPSSIQNLHKLEHLEIENcINLETLPTginlesleslDLSGCSRLR 839
PLN03150 PLN03150
hypothetical protein; Provisional
 693-783 3.95e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 40.57  E-value: 3.95e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21245134  693 FIPEEIQYLSNLQYFAVTNNNIE-MLPDGLFQCKKLQCLLLGKNSLMNLSPH-VGELSNLTHLELIGNYLETLPPELEGC 770
Cdd:PLN03150 433 FIPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNGSIPEsLGQLTSLRILNLNGNSLSGRVPAALGG 512

                         90
                 ....*....|...
gi 21245134  771 QSLKRNCLIVEEN 783
Cdd:PLN03150 513 RLLHRASFNFTDN 525
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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