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Conserved domains on  [gi|122939165|ref|NP_056147|]
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nudC domain-containing protein 3 [Homo sapiens]

Protein Classification

Hsp20/alpha crystallin family protein( domain architecture ID 10623958)

Hsp20/alpha crystallin family protein is a small, stress-induced protein, between 12-43 kDa, which functions as an ATP-independent chaperone that prevents aggregation and protects against cell stress, induced by heat, osmotic, or acid shock

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
p23_NUDCD3_like cd06495
p23-like NUD (nuclear distribution) C-like domain found in human NUDC domain-containing ...
 184-285 7.40e-67

p23-like NUD (nuclear distribution) C-like domain found in human NUDC domain-containing protein 3 (NUDCD3) and similar proteins. Little is known about the function of the proteins in this subgroup.


:

Pssm-ID: 107244  Cd Length: 102  Bit Score: 205.88  E-value: 7.40e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122939165 184 GAVRENYTWSQDYTDLEVRVPVPKHVVKGKQVSVALSSSSIRVAMLEENGERVLMEGKLTHKINTESSLWSLEPGKCVLV 263
Cdd:cd06495    1 GAVRENYTWSQDYTDVEVRVPVPKDVVKGRQVSVDLQSSSIRVSVRDGGGEKVLMEGEFTHKINTENSLWSLEPGKCVLL 80

                         90       100
                 ....*....|....*....|..
gi 122939165 264 NLSKVGEYWWNAILEGEEPIDI 285
Cdd:cd06495   81 SLSKCSEVWWNAVLKGEEEIDI 102
Nudc_N pfam14050
N-terminal conserved domain of Nudc; The N-terminus of nuclear distribution gene C homolog ...
 9-67 1.04e-28

N-terminal conserved domain of Nudc; The N-terminus of nuclear distribution gene C homolog (NUDC) proteins contains a highly conserved region consisting of a predicted three helix bundle. In the human homolog this segment has been targeted for structure determination by the Joint Center for Structural Genomics. NUDC forms a complex with other NUD proteins and is involved in several cellular division activities. Recently it was shown that NUDC regulates platelet-activating factor (PAF) acetylhydrolase with PAF being a pro-inflammatory secondary lipidic messenger.


:

Pssm-ID: 464073  Cd Length: 60  Bit Score: 105.72  E-value: 1.04e-28
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 122939165    9 YDQALLGILQHVGNVQDFLRVLFGFLYRKTDFYRLLRHPSDRMGFPPGAAQALVLQVFK 67
Cdd:pfam14050   2 HDNLLLGILQEEGGIEDFLDAFFGFLYRRTDFYHVMLDPDDKMGFPPGVAEKLVLKAFR 60
 
Name Accession Description Interval E-value
p23_NUDCD3_like cd06495
p23-like NUD (nuclear distribution) C-like domain found in human NUDC domain-containing ...
 184-285 7.40e-67

p23-like NUD (nuclear distribution) C-like domain found in human NUDC domain-containing protein 3 (NUDCD3) and similar proteins. Little is known about the function of the proteins in this subgroup.


Pssm-ID: 107244  Cd Length: 102  Bit Score: 205.88  E-value: 7.40e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122939165 184 GAVRENYTWSQDYTDLEVRVPVPKHVVKGKQVSVALSSSSIRVAMLEENGERVLMEGKLTHKINTESSLWSLEPGKCVLV 263
Cdd:cd06495    1 GAVRENYTWSQDYTDVEVRVPVPKDVVKGRQVSVDLQSSSIRVSVRDGGGEKVLMEGEFTHKINTENSLWSLEPGKCVLL 80

                         90       100
                 ....*....|....*....|..
gi 122939165 264 NLSKVGEYWWNAILEGEEPIDI 285
Cdd:cd06495   81 SLSKCSEVWWNAVLKGEEEIDI 102
Nudc_N pfam14050
N-terminal conserved domain of Nudc; The N-terminus of nuclear distribution gene C homolog ...
 9-67 1.04e-28

N-terminal conserved domain of Nudc; The N-terminus of nuclear distribution gene C homolog (NUDC) proteins contains a highly conserved region consisting of a predicted three helix bundle. In the human homolog this segment has been targeted for structure determination by the Joint Center for Structural Genomics. NUDC forms a complex with other NUD proteins and is involved in several cellular division activities. Recently it was shown that NUDC regulates platelet-activating factor (PAF) acetylhydrolase with PAF being a pro-inflammatory secondary lipidic messenger.


Pssm-ID: 464073  Cd Length: 60  Bit Score: 105.72  E-value: 1.04e-28
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 122939165    9 YDQALLGILQHVGNVQDFLRVLFGFLYRKTDFYRLLRHPSDRMGFPPGAAQALVLQVFK 67
Cdd:pfam14050   2 HDNLLLGILQEEGGIEDFLDAFFGFLYRRTDFYHVMLDPDDKMGFPPGVAEKLVLKAFR 60
CS pfam04969
CS domain; The CS and CHORD (pfam04968) are fused into a single polypeptide chain in metazoans ...
 188-267 6.51e-19

CS domain; The CS and CHORD (pfam04968) are fused into a single polypeptide chain in metazoans but are found in separate proteins in plants; this is thought to be indicative of an interaction between CS and CHORD. It has been suggested that the CS domain is a binding module for HSP90, implying that CS domain-containing proteins are involved in recruiting heat shock proteins to multiprotein assemblies. Two CS domains are found at the N-terminus of Ubiquitin carboxyl-terminal hydrolase 19 (USP19), these domains may play a role in the interaction of USP19 with cellular inhibitor of apoptosis 2.


Pssm-ID: 461503  Cd Length: 76  Bit Score: 79.99  E-value: 6.51e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122939165  188 ENYTWSQDYTDLEVRVPVPKHVVKGKQVSVALSSSSIRVAMLeenGERVLMEGKLTHKINTESSLWSLEPgKCVLVNLSK 267
Cdd:pfam04969   1 PRYDWYQTLDEVTITIPVKGAGIKKKDVKVNIKPRSLKVKIK---GGYELIDGELFHPIDPEESSWTIEG-KKVEITLKK 76
 
Name Accession Description Interval E-value
p23_NUDCD3_like cd06495
p23-like NUD (nuclear distribution) C-like domain found in human NUDC domain-containing ...
 184-285 7.40e-67

p23-like NUD (nuclear distribution) C-like domain found in human NUDC domain-containing protein 3 (NUDCD3) and similar proteins. Little is known about the function of the proteins in this subgroup.


Pssm-ID: 107244  Cd Length: 102  Bit Score: 205.88  E-value: 7.40e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122939165 184 GAVRENYTWSQDYTDLEVRVPVPKHVVKGKQVSVALSSSSIRVAMLEENGERVLMEGKLTHKINTESSLWSLEPGKCVLV 263
Cdd:cd06495    1 GAVRENYTWSQDYTDVEVRVPVPKDVVKGRQVSVDLQSSSIRVSVRDGGGEKVLMEGEFTHKINTENSLWSLEPGKCVLL 80

                         90       100
                 ....*....|....*....|..
gi 122939165 264 NLSKVGEYWWNAILEGEEPIDI 285
Cdd:cd06495   81 SLSKCSEVWWNAVLKGEEEIDI 102
Nudc_N pfam14050
N-terminal conserved domain of Nudc; The N-terminus of nuclear distribution gene C homolog ...
 9-67 1.04e-28

N-terminal conserved domain of Nudc; The N-terminus of nuclear distribution gene C homolog (NUDC) proteins contains a highly conserved region consisting of a predicted three helix bundle. In the human homolog this segment has been targeted for structure determination by the Joint Center for Structural Genomics. NUDC forms a complex with other NUD proteins and is involved in several cellular division activities. Recently it was shown that NUDC regulates platelet-activating factor (PAF) acetylhydrolase with PAF being a pro-inflammatory secondary lipidic messenger.


Pssm-ID: 464073  Cd Length: 60  Bit Score: 105.72  E-value: 1.04e-28
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 122939165    9 YDQALLGILQHVGNVQDFLRVLFGFLYRKTDFYRLLRHPSDRMGFPPGAAQALVLQVFK 67
Cdd:pfam14050   2 HDNLLLGILQEEGGIEDFLDAFFGFLYRRTDFYHVMLDPDDKMGFPPGVAEKLVLKAFR 60
p23_NUDC_like cd06467
p23_like domain of NUD (nuclear distribution) C and similar proteins. Aspergillus nidulas (An) ...
 190-277 1.62e-25

p23_like domain of NUD (nuclear distribution) C and similar proteins. Aspergillus nidulas (An) NUDC is needed for nuclear movement. AnNUDC is localized at the hyphal cortex, and binds NUDF at spindle pole bodies (SPBs) and in the cytoplasm at different stages in the cell cycle. At the SPBs it is part of the dynein molecular motor/NUDF complex that regulates microtubule dynamics. Mammalian(m) NUDC associates both with the dynein complex and also with an anti-inflammatory enzyme, platelet activating factor acetylhydrolase I, PAF-AH(I) complex, through binding mNUDF, the regulatory beta subunit of PAF-AH(I). mNUDC is important for cell proliferation both in normal and tumor tissues. Its expression is elevated in various cell types undergoing mitosis or stimulated to proliferate, with high expression levels observed in leukemic cells and tumors. For a leukemic cell line, human NUDC was shown to activate the thrombopoietin (TPO) receptor (Mpl) by binding to its extracellular domain, and promoting cell proliferation and differentiation. This group also includes the human broadly immunogenic tumor associated antigen, CML66, which is highly expressed in a variety of solid tumors and in leukemias. In normal tissues high expression of CML66 is limited to testis and heart.


Pssm-ID: 107224  Cd Length: 85  Bit Score: 98.00  E-value: 1.62e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122939165 190 YTWSQDYTDLEVRVPVPKHVvKGKQVSVALSSSSIRVAMleeNGERVLMEGKLTHKINTESSLWSLEPGKCVLVNLSKVG 269
Cdd:cd06467    1 YSWTQTLDEVTVTIPLPEGT-KSKDVKVEITPKHLKVGV---KGGEPLLDGELYAKVKVDESTWTLEDGKLLEITLEKRN 76


                 ....*....
gi 122939165 270 E-YWWNAIL 277
Cdd:cd06467   77 EgEWWPSLV 85
CS pfam04969
CS domain; The CS and CHORD (pfam04968) are fused into a single polypeptide chain in metazoans ...
 188-267 6.51e-19

CS domain; The CS and CHORD (pfam04968) are fused into a single polypeptide chain in metazoans but are found in separate proteins in plants; this is thought to be indicative of an interaction between CS and CHORD. It has been suggested that the CS domain is a binding module for HSP90, implying that CS domain-containing proteins are involved in recruiting heat shock proteins to multiprotein assemblies. Two CS domains are found at the N-terminus of Ubiquitin carboxyl-terminal hydrolase 19 (USP19), these domains may play a role in the interaction of USP19 with cellular inhibitor of apoptosis 2.


Pssm-ID: 461503  Cd Length: 76  Bit Score: 79.99  E-value: 6.51e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122939165  188 ENYTWSQDYTDLEVRVPVPKHVVKGKQVSVALSSSSIRVAMLeenGERVLMEGKLTHKINTESSLWSLEPgKCVLVNLSK 267
Cdd:pfam04969   1 PRYDWYQTLDEVTITIPVKGAGIKKKDVKVNIKPRSLKVKIK---GGYELIDGELFHPIDPEESSWTIEG-KKVEITLKK 76
p23_mNUDC_like cd06492
p23-like NUD (nuclear distribution) C-like domain of mammalian(m) NUDC and similar proteins. ...
 190-277 4.37e-14

p23-like NUD (nuclear distribution) C-like domain of mammalian(m) NUDC and similar proteins. Mammalian(m) NUDC associates both with the dynein complex and also with an anti-inflammatory enzyme, platelet activating factor acetylhydrolase I, PAF-AH(I) complex, through binding mNUDF, the regulatory beta subunit of PAF-AH(I). mNUDC is important for cell proliferation both in normal and tumor tissues. Its expression is elevated in various cell types undergoing mitosis or stimulated to proliferate, with high expression levels observed in leukemic cells and tumors. For a leukemic cell line, human NUDC was shown to activate the thrombopoietin (TPO) receptor (Mpl) by binding to its extracellular domain, and promoting cell proliferation and differentiation.


Pssm-ID: 107241  Cd Length: 87  Bit Score: 66.98  E-value: 4.37e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122939165 190 YTWSQDYTDLEVRVPVP-KHVVKGKQVSVALSSSSIRVAMleeNGERVLMEGKLTHKINTESSLWSLEPGKCVLVNLSKV 268
Cdd:cd06492    1 YRWTQTLSEVELKVPFKvSFRLKGKDVVVDIQRKHLKVGL---KGQPPIIDGELYNEVKVEESSWLIEDGKVVTVNLEKI 77

                         90
                 ....*....|
gi 122939165 269 GEY-WWNAIL 277
Cdd:cd06492   78 NKMeWWSRLV 87
p23_like cd06463
Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) ...
 192-277 9.74e-14

Proteins containing this p23_like domain include p23 and its Saccharomyces cerevisiae (Sc) homolog Sba1. Both are co-chaperones for the heat shock protein (Hsp) 90. p23 binds Hsp90 and participates in the folding of a number of Hsp90 clients, including the progesterone receptor. p23 also has a passive chaperoning activity and in addition may participate in prostaglandin synthesis. Both p23 and Sba1p can regulate telomerase activity. This group includes domains similar to the C-terminal CHORD-SGT1 (CS) domain of suppressor of G2 allele of Skp1 (Sgt1). Sgt1 interacts with multiple protein complexes and has the features of a co-chaperone. Human (h) Sgt1 interacts with both Hsp70 and Hsp90, and has been shown to bind Hsp90 through its CS domain. Saccharomyces cerevisiae (Sc) Sgt1 is a subunit of both core kinetochore and SCF (Skp1-Cul1-F-box) ubiquitin ligase complexes. Sgt1 is required for pathogen resistance in plants. This group also includes the p23_like domains of human butyrate-induced transcript 1 (hB-ind1), NUD (nuclear distribution) C, Melusin, and NAD(P)H cytochrome b5 (NCB5) oxidoreductase (OR). hB-ind1 plays a role in the signaling pathway mediated by the small GTPase Rac1, NUDC is needed for nuclear movement, Melusin interacts with two splice variants of beta1 integrin, and NCB5OR plays a part in maintaining viable pancreatic beta cells.


Pssm-ID: 107220  Cd Length: 84  Bit Score: 65.77  E-value: 9.74e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122939165 192 WSQDYTDLEVRVPVPKhvVKGKQVSVALSSSSIRVAMLEENGERVLMEGKLTHKINTESSLWSLEPGKcVLVNLSKV-GE 270
Cdd:cd06463    1 WYQTLDEVTITIPLKD--VTKKDVKVEFTPKSLTVSVKGGGGKEYLLEGELFGPIDPEESKWTVEDRK-IEITLKKKePG 77


                 ....*..
gi 122939165 271 YWWNAIL 277
Cdd:cd06463   78 EWWPRLE 84
p23_NUDCD1_like cd06493
p23_NUDCD1: p23-like NUD (nuclear distribution) C-like domain found in human NUD (nuclear ...
 190-270 7.67e-04

p23_NUDCD1: p23-like NUD (nuclear distribution) C-like domain found in human NUD (nuclear distribution) C domain-containing protein 1, NUDCD1 (also known as CML66), and similar proteins. NUDCD1/CML66 is a broadly immunogenic tumor associated antigen, which is highly expressed in a variety of solid tumors and in leukemias. In normal tissues high expression of NUDCD1/CML66 is limited to testis and heart.


Pssm-ID: 107242  Cd Length: 85  Bit Score: 37.89  E-value: 7.67e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122939165 190 YTWSQDYTDLEVRVPVPKHVVKgKQVSVALSSSSIRVAMleeNGERVLMEGKLTHKINTESSLWSLEPGKCVLVNLSKVG 269
Cdd:cd06493    1 YYWQQTEEDLTLTIRLPEDTTK-EDIRIKFLPDHISIAL---KDQAPLLEGKLYSSIDHESSTWIIKENKSLEVSLIKKD 76


                 .
gi 122939165 270 E 270
Cdd:cd06493   77 E 77
ACD_sHsps_p23-like cd00298
This domain family includes the alpha-crystallin domain (ACD) of alpha-crystallin-type small ...
 192-267 1.29e-03

This domain family includes the alpha-crystallin domain (ACD) of alpha-crystallin-type small heat shock proteins (sHsps) and a similar domain found in p23-like proteins. sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is this ACD. sHsps are generally active as large oligomers consisting of multiple subunits, and are believed to be ATP-independent chaperones that prevent aggregation and are important in refolding in combination with other Hsps. p23 is a cochaperone of the Hsp90 chaperoning pathway. It binds Hsp90 and participates in the folding of a number of Hsp90 clients including the progesterone receptor. p23 also has a passive chaperoning activity. p23 in addition may act as the cytosolic prostaglandin E2 synthase. Included in this family is the p23-like C-terminal CHORD-SGT1 (CS) domain of suppressor of G2 allele of Skp1 (Sgt1) and the p23-like domains of human butyrate-induced transcript 1 (hB-ind1), NUD (nuclear distribution) C, Melusin, and NAD(P)H cytochrome b5 (NCB5) oxidoreductase (OR).


Pssm-ID: 107219  Cd Length: 80  Bit Score: 37.18  E-value: 1.29e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 122939165 192 WSQDYTDLEVRVPVPKhvVKGKQVSVALSSSSIRV-------AMLEENGERVLMEGKLTHKINTESSLWSLEPGKcVLVN 264
Cdd:cd00298    1 WYQTDDEVVVTVDLPG--VKKEDIKVEVEDNVLTIsgkreeeEERERSYGEFERSFELPEDVDPEKSKASLENGV-LEIT 77


                 ...
gi 122939165 265 LSK 267
Cdd:cd00298   78 LPK 80
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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