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Conserved domains on  [gi|281182690|ref|NP_056077|]
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WASH complex subunit 2C isoform 1 [Homo sapiens]

Protein Classification

CAP-ZIP_m domain-containing protein( domain architecture ID 10633686)

CAP-ZIP_m domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
CAP-ZIP_m pfam15255
WASH complex subunit CAP-Z interacting, central region; This domain is found on WASH complex ...
937-1059 1.94e-65

WASH complex subunit CAP-Z interacting, central region; This domain is found on WASH complex subunits FAM21 and CAP-ZIP proteins, as well as on VPEF (vaccinia virus penetration factor). This family of proteins is found in eukaryotes. Proteins in this family are typically between 305 and 1321 amino acids in length. The exact function of this region is not known.


:

Pssm-ID: 464595 [Multi-domain]  Cd Length: 140  Bit Score: 217.39  E-value: 1.94e-65
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281182690   937 QANLAINPAALLPTAASQISEVKPVLPELAFPSSEHRRSHGLESVPVLPGSGEAGVSFDLPAQADTLHSANKSRVKMRGK 1016
Cdd:pfam15255   16 QANLAINPAALLPGAAPQIPGAKSVLPGLAFPSSEPARSTSPESTPTAQGSGEAGVSFDLPAQADTLHSANKSRAKVTGK 95
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 281182690  1017 RRPQTRAARRLAAQESSEAEDMSVPRGPIAQWADG--AISPNGHR 1059
Cdd:pfam15255   96 RRPQTRAARRLAAQESSEAEDVSSPEGAGAQLASGasPASPVASQ 140
PTZ00108 super family cl36510
DNA topoisomerase 2-like protein; Provisional
589-816 3.63e-03

DNA topoisomerase 2-like protein; Provisional


The actual alignment was detected with superfamily member PTZ00108:

Pssm-ID: 240271 [Multi-domain]  Cd Length: 1388  Bit Score: 41.96  E-value: 3.63e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281182690  589 KKQTLSLQAQREEKAKASELSKKKASALLFSSDEEDQWNIPASQTHLASDSRSKGEPRDSGTLQSQEAKAVKKTSLFEED 668
Cdd:PTZ00108 1159 KSKTKGKASKLRKPKLKKKEKKKKKSSADKSKKASVVGNSKRVDSDEKRKLDDKPDNKKSNSSGSDQEDDEEQKTKPKKS 1238
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281182690  669 KEDDLFAIAKDSQKKTQRVSLLFEDDVDSGGSLFGSPPTSVPPATKKKETVSEAPPLLFSDEEEKEAqlGVKSVDKKVES 748
Cdd:PTZ00108 1239 SVKRLKSKKNNSSKSSEDNDEFSSDDLSKEGKPKNAPKRVSAVQYSPPPPSKRPDGESNGGSKPSSP--TKKKVKKRLEG 1316
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 281182690  749 akeslkfGRTDVAESEKEGLLTRSAQETVKHSDLFSSSSPWDKGTKPRTKTVLSLFDEEEDKMEDQNI 816
Cdd:PTZ00108 1317 -------SLAALKKKKKSEKKTARKKKSKTRVKQASASQSSRLLRRPRKKKSDSSSEDDDDSEVDDSE 1377
 
Name Accession Description Interval E-value
CAP-ZIP_m pfam15255
WASH complex subunit CAP-Z interacting, central region; This domain is found on WASH complex ...
937-1059 1.94e-65

WASH complex subunit CAP-Z interacting, central region; This domain is found on WASH complex subunits FAM21 and CAP-ZIP proteins, as well as on VPEF (vaccinia virus penetration factor). This family of proteins is found in eukaryotes. Proteins in this family are typically between 305 and 1321 amino acids in length. The exact function of this region is not known.


Pssm-ID: 464595 [Multi-domain]  Cd Length: 140  Bit Score: 217.39  E-value: 1.94e-65
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281182690   937 QANLAINPAALLPTAASQISEVKPVLPELAFPSSEHRRSHGLESVPVLPGSGEAGVSFDLPAQADTLHSANKSRVKMRGK 1016
Cdd:pfam15255   16 QANLAINPAALLPGAAPQIPGAKSVLPGLAFPSSEPARSTSPESTPTAQGSGEAGVSFDLPAQADTLHSANKSRAKVTGK 95
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 281182690  1017 RRPQTRAARRLAAQESSEAEDMSVPRGPIAQWADG--AISPNGHR 1059
Cdd:pfam15255   96 RRPQTRAARRLAAQESSEAEDVSSPEGAGAQLASGasPASPVASQ 140
PTZ00108 PTZ00108
DNA topoisomerase 2-like protein; Provisional
589-816 3.63e-03

DNA topoisomerase 2-like protein; Provisional


Pssm-ID: 240271 [Multi-domain]  Cd Length: 1388  Bit Score: 41.96  E-value: 3.63e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281182690  589 KKQTLSLQAQREEKAKASELSKKKASALLFSSDEEDQWNIPASQTHLASDSRSKGEPRDSGTLQSQEAKAVKKTSLFEED 668
Cdd:PTZ00108 1159 KSKTKGKASKLRKPKLKKKEKKKKKSSADKSKKASVVGNSKRVDSDEKRKLDDKPDNKKSNSSGSDQEDDEEQKTKPKKS 1238
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281182690  669 KEDDLFAIAKDSQKKTQRVSLLFEDDVDSGGSLFGSPPTSVPPATKKKETVSEAPPLLFSDEEEKEAqlGVKSVDKKVES 748
Cdd:PTZ00108 1239 SVKRLKSKKNNSSKSSEDNDEFSSDDLSKEGKPKNAPKRVSAVQYSPPPPSKRPDGESNGGSKPSSP--TKKKVKKRLEG 1316
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 281182690  749 akeslkfGRTDVAESEKEGLLTRSAQETVKHSDLFSSSSPWDKGTKPRTKTVLSLFDEEEDKMEDQNI 816
Cdd:PTZ00108 1317 -------SLAALKKKKKSEKKTARKKKSKTRVKQASASQSSRLLRRPRKKKSDSSSEDDDDSEVDDSE 1377
 
Name Accession Description Interval E-value
CAP-ZIP_m pfam15255
WASH complex subunit CAP-Z interacting, central region; This domain is found on WASH complex ...
937-1059 1.94e-65

WASH complex subunit CAP-Z interacting, central region; This domain is found on WASH complex subunits FAM21 and CAP-ZIP proteins, as well as on VPEF (vaccinia virus penetration factor). This family of proteins is found in eukaryotes. Proteins in this family are typically between 305 and 1321 amino acids in length. The exact function of this region is not known.


Pssm-ID: 464595 [Multi-domain]  Cd Length: 140  Bit Score: 217.39  E-value: 1.94e-65
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281182690   937 QANLAINPAALLPTAASQISEVKPVLPELAFPSSEHRRSHGLESVPVLPGSGEAGVSFDLPAQADTLHSANKSRVKMRGK 1016
Cdd:pfam15255   16 QANLAINPAALLPGAAPQIPGAKSVLPGLAFPSSEPARSTSPESTPTAQGSGEAGVSFDLPAQADTLHSANKSRAKVTGK 95
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 281182690  1017 RRPQTRAARRLAAQESSEAEDMSVPRGPIAQWADG--AISPNGHR 1059
Cdd:pfam15255   96 RRPQTRAARRLAAQESSEAEDVSSPEGAGAQLASGasPASPVASQ 140
PTZ00108 PTZ00108
DNA topoisomerase 2-like protein; Provisional
589-816 3.63e-03

DNA topoisomerase 2-like protein; Provisional


Pssm-ID: 240271 [Multi-domain]  Cd Length: 1388  Bit Score: 41.96  E-value: 3.63e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281182690  589 KKQTLSLQAQREEKAKASELSKKKASALLFSSDEEDQWNIPASQTHLASDSRSKGEPRDSGTLQSQEAKAVKKTSLFEED 668
Cdd:PTZ00108 1159 KSKTKGKASKLRKPKLKKKEKKKKKSSADKSKKASVVGNSKRVDSDEKRKLDDKPDNKKSNSSGSDQEDDEEQKTKPKKS 1238
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 281182690  669 KEDDLFAIAKDSQKKTQRVSLLFEDDVDSGGSLFGSPPTSVPPATKKKETVSEAPPLLFSDEEEKEAqlGVKSVDKKVES 748
Cdd:PTZ00108 1239 SVKRLKSKKNNSSKSSEDNDEFSSDDLSKEGKPKNAPKRVSAVQYSPPPPSKRPDGESNGGSKPSSP--TKKKVKKRLEG 1316
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 281182690  749 akeslkfGRTDVAESEKEGLLTRSAQETVKHSDLFSSSSPWDKGTKPRTKTVLSLFDEEEDKMEDQNI 816
Cdd:PTZ00108 1317 -------SLAALKKKKKSEKKTARKKKSKTRVKQASASQSSRLLRRPRKKKSDSSSEDDDDSEVDDSE 1377
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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