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Conserved domains on  [gi|46049063|ref|NP_055986|]
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exportin-6 isoform 2 [Homo sapiens]

Protein Classification

exportin/importin beta family protein( domain architecture ID 10658450)

exportin/importin beta family protein such as human exportin-T, which mediates the nuclear export of aminoacylated tRNAs or transportin-3 (importin), which transports target proteins into the nucleus

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Xpo1 pfam08389
Exportin 1-like protein; The sequences featured in this family are similar to a region close ...
 103-253 2.73e-23

Exportin 1-like protein; The sequences featured in this family are similar to a region close to the N-terminus of yeast exportin 1 (Xpo1, Crm1). This region is found just C-terminal to an importin-beta N-terminal domain (pfam03810) in many members of this family. Exportin 1 is a nuclear export receptor that interacts with leucine-rich nuclear export signal (NES) sequences, and Ran-GTP, and is involved in translocation of proteins out of the nucleus.


:

Pssm-ID: 462459  Cd Length: 147  Bit Score: 96.91  E-value: 2.73e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46049063    103 PYFIRNKLCKVIVDIGRQDWPMFYHDFFTNILQLIQS-PVTTPLGLIMLKTTSEELAC-PREDLSVARKEELRKLLLDQV 180
Cdd:pfam08389    1 PKFIRNKLALALAELAKQEYPNNWPTFFPDLISLLSSnPTGCELFLRILKVLPEEIFDfSRTSLTQDRNNRLKDLLRSNM 80

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 46049063    181 QTVLGLLTGILETVWDKHsvtaatpppSPTSGESGDLLSNLLQSPSSAKLLNQpiPILDVESEYI-----CSLALECL 253
Cdd:pfam08389   81 EQILELLLQILEASQNAN---------SELVEAVLKCLGSWLSWIPIGLIVNN--PLLNLLFSLLndpdlREAAVECL 147
IBN_N smart00913
Importin-beta N-terminal domain; Members of the importin-beta (karyopherin-beta) family can ...
 31-96 2.56e-13

Importin-beta N-terminal domain; Members of the importin-beta (karyopherin-beta) family can bind and transport cargo by themselves, or can form heterodimers with importin-alpha. As part of a heterodimer, importin-beta mediates interactions with the pore complex, while importin-alpha acts as an adaptor protein to bind the nuclear localisation signal (NLS) on the cargo through the classical NLS import of proteins. Importin-beta is a helicoidal molecule constructed from 19 HEAT repeats. Many nuclear pore proteins contain FG sequence repeats that can bind to HEAT repeats within importins.. which is important for importin-beta mediated transport.


:

Pssm-ID: 197981 [Multi-domain]  Cd Length: 67  Bit Score: 65.73  E-value: 2.56e-13
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 46049063      31 IEELLNNFAQQIGAWRFCLYFLSSTRNDYVMMYSLTVFENLINKMWLGVPSQDKMEIRSCLPKLLL 96
Cdd:smart00913    1 AEKQLEQFQKSPGFWLLLLEILANSEDQYVRQLAAITLKNKITRRWSSLPEEEKEEIKNSLLELLL 66
 
Name Accession Description Interval E-value
Xpo1 pfam08389
Exportin 1-like protein; The sequences featured in this family are similar to a region close ...
 103-253 2.73e-23

Exportin 1-like protein; The sequences featured in this family are similar to a region close to the N-terminus of yeast exportin 1 (Xpo1, Crm1). This region is found just C-terminal to an importin-beta N-terminal domain (pfam03810) in many members of this family. Exportin 1 is a nuclear export receptor that interacts with leucine-rich nuclear export signal (NES) sequences, and Ran-GTP, and is involved in translocation of proteins out of the nucleus.


Pssm-ID: 462459  Cd Length: 147  Bit Score: 96.91  E-value: 2.73e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46049063    103 PYFIRNKLCKVIVDIGRQDWPMFYHDFFTNILQLIQS-PVTTPLGLIMLKTTSEELAC-PREDLSVARKEELRKLLLDQV 180
Cdd:pfam08389    1 PKFIRNKLALALAELAKQEYPNNWPTFFPDLISLLSSnPTGCELFLRILKVLPEEIFDfSRTSLTQDRNNRLKDLLRSNM 80

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 46049063    181 QTVLGLLTGILETVWDKHsvtaatpppSPTSGESGDLLSNLLQSPSSAKLLNQpiPILDVESEYI-----CSLALECL 253
Cdd:pfam08389   81 EQILELLLQILEASQNAN---------SELVEAVLKCLGSWLSWIPIGLIVNN--PLLNLLFSLLndpdlREAAVECL 147
IBN_N smart00913
Importin-beta N-terminal domain; Members of the importin-beta (karyopherin-beta) family can ...
 31-96 2.56e-13

Importin-beta N-terminal domain; Members of the importin-beta (karyopherin-beta) family can bind and transport cargo by themselves, or can form heterodimers with importin-alpha. As part of a heterodimer, importin-beta mediates interactions with the pore complex, while importin-alpha acts as an adaptor protein to bind the nuclear localisation signal (NLS) on the cargo through the classical NLS import of proteins. Importin-beta is a helicoidal molecule constructed from 19 HEAT repeats. Many nuclear pore proteins contain FG sequence repeats that can bind to HEAT repeats within importins.. which is important for importin-beta mediated transport.


Pssm-ID: 197981 [Multi-domain]  Cd Length: 67  Bit Score: 65.73  E-value: 2.56e-13
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 46049063      31 IEELLNNFAQQIGAWRFCLYFLSSTRNDYVMMYSLTVFENLINKMWLGVPSQDKMEIRSCLPKLLL 96
Cdd:smart00913    1 AEKQLEQFQKSPGFWLLLLEILANSEDQYVRQLAAITLKNKITRRWSSLPEEEKEEIKNSLLELLL 66
CRM1 COG5101
Importin beta-related nuclear transport receptor [Nuclear structure / Intracellular ...
 3-192 3.47e-09

Importin beta-related nuclear transport receptor [Nuclear structure / Intracellular trafficking and secretion];


Pssm-ID: 227432 [Multi-domain]  Cd Length: 1053  Bit Score: 61.11  E-value: 3.47e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46049063    3 SEEASLRALESLMTEFFhdCTTNERKREIEELLNNFAQQIGAWRFCLYFLSSTRNDYVMMYSLTVFENLINKMWLGVPSQ 82
Cdd:COG5101    8 DKDLDIALLDKVVTTFY--QGDGRKQEQAQRILTKFQELPDAWTKADYILNNSKLPQSKYIALSLLDKLITTKWKLLPEG 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46049063   83 DKMEIRSCLPKLLLAH------HKTLPYFIrNKLCKVIVDIGRQDWPMFYHDFFTNILQLIQSPVTT-PLGLIMLKTTSE 155
Cdd:COG5101   86 MRQGIRNYVVQLVIEKsqddkvRDKQKYVL-NKLDLTLVQILKQEWPRNWPTFIPELINVSQISMEVcENNMIVLKLLSE 164

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 46049063  156 ELACPRED-LSVARKEELRKLLLDQVQTVLGLLTGILE 192
Cdd:COG5101  165 EVFDFSAEqMTQVKKRLLKNQMKIEFPQIFGLCKQILE 202
IBN_N pfam03810
Importin-beta N-terminal domain;
32-96 1.05e-04

Importin-beta N-terminal domain;


Pssm-ID: 397745 [Multi-domain]  Cd Length: 72  Bit Score: 41.46  E-value: 1.05e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46049063     32 EELLNNFAQQIGAWRFCLYFLSSTRND-YVMMYSLTVFENLINKMW----LGVPSQDKMEIRSCLPKLLL 96
Cdd:pfam03810    2 EKQLEQFEKSPGFWSKLLQILSNSENPlEVRQLAALYLKNLITRHWeeekNSLPPEEKEQIKNNLLNLLG 71
 
Name Accession Description Interval E-value
Xpo1 pfam08389
Exportin 1-like protein; The sequences featured in this family are similar to a region close ...
 103-253 2.73e-23

Exportin 1-like protein; The sequences featured in this family are similar to a region close to the N-terminus of yeast exportin 1 (Xpo1, Crm1). This region is found just C-terminal to an importin-beta N-terminal domain (pfam03810) in many members of this family. Exportin 1 is a nuclear export receptor that interacts with leucine-rich nuclear export signal (NES) sequences, and Ran-GTP, and is involved in translocation of proteins out of the nucleus.


Pssm-ID: 462459  Cd Length: 147  Bit Score: 96.91  E-value: 2.73e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46049063    103 PYFIRNKLCKVIVDIGRQDWPMFYHDFFTNILQLIQS-PVTTPLGLIMLKTTSEELAC-PREDLSVARKEELRKLLLDQV 180
Cdd:pfam08389    1 PKFIRNKLALALAELAKQEYPNNWPTFFPDLISLLSSnPTGCELFLRILKVLPEEIFDfSRTSLTQDRNNRLKDLLRSNM 80

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 46049063    181 QTVLGLLTGILETVWDKHsvtaatpppSPTSGESGDLLSNLLQSPSSAKLLNQpiPILDVESEYI-----CSLALECL 253
Cdd:pfam08389   81 EQILELLLQILEASQNAN---------SELVEAVLKCLGSWLSWIPIGLIVNN--PLLNLLFSLLndpdlREAAVECL 147
IBN_N smart00913
Importin-beta N-terminal domain; Members of the importin-beta (karyopherin-beta) family can ...
 31-96 2.56e-13

Importin-beta N-terminal domain; Members of the importin-beta (karyopherin-beta) family can bind and transport cargo by themselves, or can form heterodimers with importin-alpha. As part of a heterodimer, importin-beta mediates interactions with the pore complex, while importin-alpha acts as an adaptor protein to bind the nuclear localisation signal (NLS) on the cargo through the classical NLS import of proteins. Importin-beta is a helicoidal molecule constructed from 19 HEAT repeats. Many nuclear pore proteins contain FG sequence repeats that can bind to HEAT repeats within importins.. which is important for importin-beta mediated transport.


Pssm-ID: 197981 [Multi-domain]  Cd Length: 67  Bit Score: 65.73  E-value: 2.56e-13
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 46049063      31 IEELLNNFAQQIGAWRFCLYFLSSTRNDYVMMYSLTVFENLINKMWLGVPSQDKMEIRSCLPKLLL 96
Cdd:smart00913    1 AEKQLEQFQKSPGFWLLLLEILANSEDQYVRQLAAITLKNKITRRWSSLPEEEKEEIKNSLLELLL 66
CRM1 COG5101
Importin beta-related nuclear transport receptor [Nuclear structure / Intracellular ...
 3-192 3.47e-09

Importin beta-related nuclear transport receptor [Nuclear structure / Intracellular trafficking and secretion];


Pssm-ID: 227432 [Multi-domain]  Cd Length: 1053  Bit Score: 61.11  E-value: 3.47e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46049063    3 SEEASLRALESLMTEFFhdCTTNERKREIEELLNNFAQQIGAWRFCLYFLSSTRNDYVMMYSLTVFENLINKMWLGVPSQ 82
Cdd:COG5101    8 DKDLDIALLDKVVTTFY--QGDGRKQEQAQRILTKFQELPDAWTKADYILNNSKLPQSKYIALSLLDKLITTKWKLLPEG 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46049063   83 DKMEIRSCLPKLLLAH------HKTLPYFIrNKLCKVIVDIGRQDWPMFYHDFFTNILQLIQSPVTT-PLGLIMLKTTSE 155
Cdd:COG5101   86 MRQGIRNYVVQLVIEKsqddkvRDKQKYVL-NKLDLTLVQILKQEWPRNWPTFIPELINVSQISMEVcENNMIVLKLLSE 164

                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 46049063  156 ELACPRED-LSVARKEELRKLLLDQVQTVLGLLTGILE 192
Cdd:COG5101  165 EVFDFSAEqMTQVKKRLLKNQMKIEFPQIFGLCKQILE 202
IBN_N pfam03810
Importin-beta N-terminal domain;
32-96 1.05e-04

Importin-beta N-terminal domain;


Pssm-ID: 397745 [Multi-domain]  Cd Length: 72  Bit Score: 41.46  E-value: 1.05e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46049063     32 EELLNNFAQQIGAWRFCLYFLSSTRND-YVMMYSLTVFENLINKMW----LGVPSQDKMEIRSCLPKLLL 96
Cdd:pfam03810    2 EKQLEQFEKSPGFWSKLLQILSNSENPlEVRQLAALYLKNLITRHWeeekNSLPPEEKEQIKNNLLNLLG 71
SXM1 COG5656
Importin, protein involved in nuclear import [Posttranslational modification, protein turnover, ...
 12-150 2.13e-03

Importin, protein involved in nuclear import [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227943 [Multi-domain]  Cd Length: 970  Bit Score: 42.15  E-value: 2.13e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46049063   12 ESLMTEFFHDCTTNERKREIEEL-LNNFAQQIGAWRFCLYFLSSTRNDY-VMMYSLTVFENLINKMW-----LGVPSQDK 84
Cdd:COG5656    3 EELLQCFLQTLDADAGKRTIAEAmLKDLEKQPGFVMALLHICSKDEGDLnVKLSAAIYFKNKIIRSWsskrdDGIKADEK 82

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 46049063   85 MEIRSCLPKLLLAHHKTLPYFIRNKLCKVIVDIGRQDWPMFYHDFFTNILQLIQSPVTTPL--GLIML 150
Cdd:COG5656   83 SEAKKYLIENILDVFLYSPEVTRTALNAILVNIFSEDKPSDLWGLFPKAANLLRSSEANHVytGLLCL 150
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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