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Conserved domains on  [gi|14149657|ref|NP_055787|]
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ribosome quality control complex subunit TCF25 [Homo sapiens]

Protein Classification

transcriptional repressor TCF25 family protein( domain architecture ID 10522689)

transcriptional repressor TCF25 family protein similar to Homo sapiens transcription factor 25 (TCF25) that acts as a transcriptional repressor, and Saccharomyces cerevisiae ribosome quality control complex subunit 1, a component of the ribosome quality control complex (RQC) that mediates ubiquitination

Gene Ontology:  GO:0072344|GO:1990112

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Tcf25 pfam04910
Transcriptional repressor TCF25; Members of this family are transcriptional repressors. They ...
 248-588 1.43e-173

Transcriptional repressor TCF25; Members of this family are transcriptional repressors. They may act by increasing histone deacetylase activity at promoter regions.


:

Pssm-ID: 461476  Cd Length: 323  Bit Score: 497.87  E-value: 1.43e-173
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14149657   248 FAFEHSEEYQQAQHKFLVAVESMEPNNIVVLLQTSPYHVDSLLQLSDACRFQEDQEMARDLVERALYSMECAFHPLFSLT 327
Cdd:pfam04910   1 FKFEHSKEYQAVQRFFLSAVESPDPEALIALLQKYPYHVDTLLQLSEVCRQGEDKSTANDLIERALFAFERAFHPLFNLT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14149657   328 SGACRLDYRRPENRSFYLALYKQMSFLEKRGCPRTALEYCKLILSLEPDEDPLCMLLLIDHLALRARNYEYLIRLFQEWE 407
Cdd:pfam04910  81 SGLCRLDYRRFENRQFFLALFRHIQFLGRRGCWRTALEFCKLLLSLDPLEDPLGALLFIDFYALKSKEYEWLIRLSEEWE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14149657   408 AHRNLSQLPNFAFSVPLAYFLLsqqtdlpECEQSSARQKASLLIQQALTMFPGVLLPLLESCSVRPDASVSSHRFFGPNA 487
Cdd:pfam04910 161 SQRNLSQLPGFAFSTALALLLL-------EEERLGDHEKADEALQKALLMFPGVLPPLLDKCGVQLPAKVRSHPFFKSES 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14149657   488 EISQPPALSQLVNLYLGRSHFLWKEPATMSWLEENVHEVLQAVDAGDPAVEacenrrkvlyqrAPRNIHRHVILSEIKEA 567
Cdd:pfam04910 234 SNSQSAALHLLSKLYVERSKSLWKEPEVLSWLESNVLSVLKRSKSKSEEVP------------LPRNILRHVILSEEKSL 301

                         330       340
                  ....*....|....*....|..
gi 14149657   568 VAALPPDVT-TQSVMGFDPLPP 588
Cdd:pfam04910 302 MAALPPEIWsSEPVLEFDPLPP 323
 
Name Accession Description Interval E-value
Tcf25 pfam04910
Transcriptional repressor TCF25; Members of this family are transcriptional repressors. They ...
 248-588 1.43e-173

Transcriptional repressor TCF25; Members of this family are transcriptional repressors. They may act by increasing histone deacetylase activity at promoter regions.


Pssm-ID: 461476  Cd Length: 323  Bit Score: 497.87  E-value: 1.43e-173
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14149657   248 FAFEHSEEYQQAQHKFLVAVESMEPNNIVVLLQTSPYHVDSLLQLSDACRFQEDQEMARDLVERALYSMECAFHPLFSLT 327
Cdd:pfam04910   1 FKFEHSKEYQAVQRFFLSAVESPDPEALIALLQKYPYHVDTLLQLSEVCRQGEDKSTANDLIERALFAFERAFHPLFNLT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14149657   328 SGACRLDYRRPENRSFYLALYKQMSFLEKRGCPRTALEYCKLILSLEPDEDPLCMLLLIDHLALRARNYEYLIRLFQEWE 407
Cdd:pfam04910  81 SGLCRLDYRRFENRQFFLALFRHIQFLGRRGCWRTALEFCKLLLSLDPLEDPLGALLFIDFYALKSKEYEWLIRLSEEWE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14149657   408 AHRNLSQLPNFAFSVPLAYFLLsqqtdlpECEQSSARQKASLLIQQALTMFPGVLLPLLESCSVRPDASVSSHRFFGPNA 487
Cdd:pfam04910 161 SQRNLSQLPGFAFSTALALLLL-------EEERLGDHEKADEALQKALLMFPGVLPPLLDKCGVQLPAKVRSHPFFKSES 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14149657   488 EISQPPALSQLVNLYLGRSHFLWKEPATMSWLEENVHEVLQAVDAGDPAVEacenrrkvlyqrAPRNIHRHVILSEIKEA 567
Cdd:pfam04910 234 SNSQSAALHLLSKLYVERSKSLWKEPEVLSWLESNVLSVLKRSKSKSEEVP------------LPRNILRHVILSEEKSL 301

                         330       340
                  ....*....|....*....|..
gi 14149657   568 VAALPPDVT-TQSVMGFDPLPP 588
Cdd:pfam04910 302 MAALPPEIWsSEPVLEFDPLPP 323
 
Name Accession Description Interval E-value
Tcf25 pfam04910
Transcriptional repressor TCF25; Members of this family are transcriptional repressors. They ...
 248-588 1.43e-173

Transcriptional repressor TCF25; Members of this family are transcriptional repressors. They may act by increasing histone deacetylase activity at promoter regions.


Pssm-ID: 461476  Cd Length: 323  Bit Score: 497.87  E-value: 1.43e-173
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14149657   248 FAFEHSEEYQQAQHKFLVAVESMEPNNIVVLLQTSPYHVDSLLQLSDACRFQEDQEMARDLVERALYSMECAFHPLFSLT 327
Cdd:pfam04910   1 FKFEHSKEYQAVQRFFLSAVESPDPEALIALLQKYPYHVDTLLQLSEVCRQGEDKSTANDLIERALFAFERAFHPLFNLT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14149657   328 SGACRLDYRRPENRSFYLALYKQMSFLEKRGCPRTALEYCKLILSLEPDEDPLCMLLLIDHLALRARNYEYLIRLFQEWE 407
Cdd:pfam04910  81 SGLCRLDYRRFENRQFFLALFRHIQFLGRRGCWRTALEFCKLLLSLDPLEDPLGALLFIDFYALKSKEYEWLIRLSEEWE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14149657   408 AHRNLSQLPNFAFSVPLAYFLLsqqtdlpECEQSSARQKASLLIQQALTMFPGVLLPLLESCSVRPDASVSSHRFFGPNA 487
Cdd:pfam04910 161 SQRNLSQLPGFAFSTALALLLL-------EEERLGDHEKADEALQKALLMFPGVLPPLLDKCGVQLPAKVRSHPFFKSES 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 14149657   488 EISQPPALSQLVNLYLGRSHFLWKEPATMSWLEENVHEVLQAVDAGDPAVEacenrrkvlyqrAPRNIHRHVILSEIKEA 567
Cdd:pfam04910 234 SNSQSAALHLLSKLYVERSKSLWKEPEVLSWLESNVLSVLKRSKSKSEEVP------------LPRNILRHVILSEEKSL 301

                         330       340
                  ....*....|....*....|..
gi 14149657   568 VAALPPDVT-TQSVMGFDPLPP 588
Cdd:pfam04910 302 MAALPPEIWsSEPVLEFDPLPP 323
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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