|
Name |
Accession |
Description |
Interval |
E-value |
| ZIP_TSC22D2 |
cd21939 |
leucine zipper domain found in TSC22 domain family protein 2; TSC22 domain family protein 2 ... |
693-755 |
1.04e-37 |
|
leucine zipper domain found in TSC22 domain family protein 2; TSC22 domain family protein 2 (TSC22D2), also called transforming growth factor beta-stimulated clone 22 domain family member 2, or TSC22-related-inducible leucine zipper protein 4 (TILZ4), may participate in the regulation of cell growth. It interacts with pyruvate kinase isoform M2 (PKM2) and WD repeat domain 77 (WDR77). The model corresponds to the conserved leucine zipper (ZIP) domain located at the C-terminus of TSC22D2. Its first helix is not basic and does not contain the consensus sequence, NXX(A)(A)XX(C/S)R, found in most basic region/leucine zipper (bZIP) proteins. Thus, the DNA-binding capability of the ZIP domain is not obvious. Similar to bZIP, ZIP forms homo- and heterodimers, resulting in many dimers that may have different effects on transcription.
Pssm-ID: 409279 Cd Length: 63 Bit Score: 134.71 E-value: 1.04e-37
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 7662236 693 AMDLVKSHLMYAVREEVEVLKEQIKELVERNSLLERENALLKSLSSNDQLSQLPTQQANPGST 755
Cdd:cd21939 1 AMDLVKSHLMYAVREEVEVLKEQIKELIERNSLLERENALLKSLSNNDQLSQLSTQQGNPSST 63
|
|
| TSC22 |
pfam01166 |
TSC-22/dip/bun family; |
694-750 |
1.42e-29 |
|
TSC-22/dip/bun family;
Pssm-ID: 460093 Cd Length: 57 Bit Score: 111.25 E-value: 1.42e-29
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*..
gi 7662236 694 MDLVKSHLMYAVREEVEVLKEQIKELVERNSLLERENALLKSLSSNDQLSQLPTQQA 750
Cdd:pfam01166 1 MDLVKSHLMYAVREEVEVLKEQIKELEERNSQLEEENSILRANASPEQLEQLSSQLQ 57
|
|
| ZIP_TSC22D4 |
cd21941 |
leucine zipper domain found in TSC22 domain family protein 4; TSC22 domain family protein 4 ... |
684-749 |
1.61e-29 |
|
leucine zipper domain found in TSC22 domain family protein 4; TSC22 domain family protein 4 (TSC22D4), also called TSC22-related-inducible leucine zipper protein 2 (TILZ2), or Tsc-22-like protein THG-1, is a transcriptional repressor that acts as a molecular determinant of insulin signalling and glucose handling. It also functions in hepatic lipid handling by regulating hepatic very-low-density-lipoprotein (VLDL) release and lipogenic gene expression. This model corresponds to the conserved leucine zipper (ZIP) domain located at the C-terminus of TSC22D4. Its first helix is not basic and does not contain the consensus sequence, NXX(A)(A)XX(C/S)R, found in most basic region/leucine zipper (bZIP) proteins. Thus, the DNA-binding capability of the ZIP domain is not obvious. Similar to bZIP, ZIP forms homo- and heterodimers, resulting in many dimers that may have different effects on transcription.
Pssm-ID: 409281 Cd Length: 74 Bit Score: 111.57 E-value: 1.61e-29
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 7662236 684 VAIDNKIEQAMDLVKSHLMYAVREEVEVLKEQIKELVERNSLLERENALLKSLSSNDQLSQLPTQQ 749
Cdd:cd21941 1 VAIDNKIEQAMDLVKSHLLFAVREEVEVLKEQIKELSERNAALEQENSLLRSLATPQQLSRLQSRQ 66
|
|
| ZIP_TSC22D |
cd21936 |
leucine zipper domain found in the TSC22 domain family of leucine zipper transcription factors; ... |
693-741 |
5.80e-27 |
|
leucine zipper domain found in the TSC22 domain family of leucine zipper transcription factors; The TGF-beta-stimulated clone-22 domain (TSC22D) family includes TSC22D1-4 and similar proteins. They have diverse physiological functions, including cell growth, development, homeostasis, and immune regulation. All family members contain a conserved leucine zipper (ZIP) domain located at the C-terminus. Its first helix is not basic and does not contain the consensus sequence, NXX(A)(A)XX(C/S)R, found in most basic region/leucine zipper (bZIP) proteins. In the bZIP family of transcription factors, the leucine zipper acts as a dimerization domain and the upstream basic region as a DNA-binding domain. However, DNA-binding capability of TSC22D family proteins is not obvious, due to the lack of the basic region found in the original bZIP DNA-binding domains. Similar to bZIP, ZIP forms homo- and heterodimers, resulting in many dimers that may have different effects on transcription.
Pssm-ID: 409276 Cd Length: 49 Bit Score: 103.41 E-value: 5.80e-27
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 7662236 693 AMDLVKSHLMYAVREEVEVLKEQIKELVERNSLLERENALLKSLSSNDQ 741
Cdd:cd21936 1 AMDLVKSHLMFAVREEVDVLKEQIAELEERISQLERENSLLRSNAPPEV 49
|
|
| ZIP_TSC22D1 |
cd21938 |
leucine zipper domain found in TSC22 domain family protein 1; TSC22 domain family protein 1 ... |
689-759 |
4.52e-25 |
|
leucine zipper domain found in TSC22 domain family protein 1; TSC22 domain family protein 1 (TSC22D1) is also called cerebral protein 2, regulatory protein TSC-22, TGFB-stimulated clone 22, or transforming growth factor beta-1-induced transcript 4 protein (TGFB1I4). It is a transcriptional repressor that was reported to be present in both the cytoplasmic and the nuclear fraction. It is activated by transcription growth factor-beta1 and other growth factors of osteoblastic cells. TSC22D1 acts on the C-type natriuretic peptide (CNP) promoter. It enhances c-Myc-mediated activation of the telomerase reverse transcriptase (TERT) promoter. This model corresponds to the conserved leucine zipper (ZIP) domain located at the C-terminus of TSC22D1. Its first helix is not basic and does not contain the consensus sequence, NXX(A)(A)XX(C/S)R, found in most basic region/leucine zipper (bZIP) proteins. Thus, the DNA-binding capability of the ZIP domain is not obvious. Similar to bZIP, ZIP forms homo- and heterodimers, resulting in many dimers that may have different effects on transcription.
Pssm-ID: 409278 Cd Length: 79 Bit Score: 99.06 E-value: 4.52e-25
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 7662236 689 KIEQAMDLVKSHLMYAVREEVEVLKEQIKELVERNSLLERENALLKSLSSNDQLSQLPT--QQANPGSTSQQQ 759
Cdd:cd21938 1 KIEQAMDLVKSHLMYAVREEVEVLKEQIKELIEKNSQLEQENNLLKTLASPEQLAQFQAqlQTGSPPSSSQPP 73
|
|
| ZIP_TSC22D3 |
cd21940 |
leucine zipper domain found in TSC22 domain family protein 3; TSC22 domain family protein 3 ... |
693-752 |
1.37e-23 |
|
leucine zipper domain found in TSC22 domain family protein 3; TSC22 domain family protein 3 (TSC22D3) is also called DSIP-immunoreactive peptide, protein DIP, delta sleep-inducing peptide immunoreactor, glucocorticoid-induced leucine zipper protein (GILZ), TSC-22-like protein, or TSC-22-related protein (TSC-22R). It protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11. In macrophages, it plays a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10. In T-cells, it inhibits anti-CD3-induced NFKB1 nuclear translocation. TSC22D3 contains a leucine zipper motif, a Pro/Glu rich domain, and three potential phosphorylation sites. This model corresponds to the leucine zipper (ZIP) domain. Its first helix is not basic and does not contain the consensus sequence, NXX(A)(A)XX(C/S)R, found in most basic region/leucine zipper (bZIP) proteins. Thus, the DNA-binding capability of the ZIP domain is not obvious. Similar to bZIP, ZIP forms homo- and heterodimers, resulting in many dimers that may have different effects on transcription.
Pssm-ID: 409280 Cd Length: 81 Bit Score: 95.02 E-value: 1.37e-23
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 7662236 693 AMDLVKSHLMYAVREEVEVLKEQIKELVERNSLLERENALLKSLSSNDQL----SQLPTQQANP 752
Cdd:cd21940 1 AMDLVKNHLMYAVREEVEVLKEQIKELVEKNSQLERENSLLKTLASPEQLekfqSRLPSEETAP 64
|
|
| ZIP_TSC22D-like |
cd21927 |
leucine zipper found in the TSC22 domain leucine zipper transcription factors, c-Myc-binding ... |
694-741 |
7.48e-18 |
|
leucine zipper found in the TSC22 domain leucine zipper transcription factors, c-Myc-binding protein, and similar proteins; The family includes TGF-beta-stimulated clone-22 domain (TSC22D) leucine zipper transcription factors, TSC22D1-4, as well as c-Myc-binding protein (MycBP). TSC22D proteins have diverse physiological functions, including cell growth, development, homeostasis, and immune regulation. MycBP, also called associate of Myc 1 (AMY-1), is a novel c-Myc binding protein that may control the transcriptional activity of Myc. It stimulates the activation of E box-dependent transcription by Myc. Members of this family contain a conserved leucine zipper (ZIP) domain. Its first helix is not basic and does not contain the consensus sequence, NXX(A)(A)XX(C/S)R, found in most basic region/leucine zipper (bZIP) proteins. In the bZIP family of transcription factors, the leucine zipper acts as a dimerization domain and the upstream basic region as a DNA-binding domain. However, DNA-binding capability of TSC22D family proteins is not obvious, due to the lack of the basic region found in the original bZIP DNA-binding domains. Similar to bZIP, ZIP forms homo- and heterodimers, resulting in many dimers that may have different effects on transcription.
Pssm-ID: 409275 Cd Length: 51 Bit Score: 77.94 E-value: 7.48e-18
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|
gi 7662236 694 MDLVKSHLMYAVREE--VEVLKEQIKELVERNSLLERENALLKSLSSNDQ 741
Cdd:cd21927 2 LDFLKHHLGAATPENpeIELLRLELAEMKEKYEAIVEENKKLKAKLAQYE 51
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
138-642 |
1.22e-11 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 68.81 E-value: 1.22e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236 138 QLAGSSAGPVTAAPSQPPTTCSSRFRVIKLDHGSGEPYRRgRWTCMEYYERDSDSSVLTRSGDCIRHSSTFDQTaeRDSG 217
Cdd:PHA03247 2611 PAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPE-RPRDDPAPGRVSRPRRARRLGRAAQASSPPQRP--RRRA 2687
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236 218 LGATGGSVVVVVASMQGAHGPESGTDSSLTAVSQLPPSEKMSQPTPAQPqsfsvGQPQPPPPPVGGAVAQSSAPLPPFPG 297
Cdd:PHA03247 2688 ARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALP-----AAPAPPAVPAGPATPGGPARPARPPT 2762
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236 298 AATGPQPMMAAAQPSQPQGAGPGGQTLPPTNVTLAQPAMSLPPQPGPAVGAPAAQQPQQFAYPQPQIPPGHLLPVQPSGQ 377
Cdd:PHA03247 2763 TAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPP 2842
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236 378 SEYLQQHVAGLQPPSPAQPSSTGAAASPATAAtlPVGTGQNASSVGAQLMGASSQPSEAMAPRTGPAQGGQVAPCQPTGV 457
Cdd:PHA03247 2843 PGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAK--PAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQ 2920
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236 458 PPATVGGVVQPCLGPAGAGQPQSVPPPQMGGSGPLSAVPGGPH--AVVPG---VPNVPAAVPAPSV--PSVSTTSVTMPN 530
Cdd:PHA03247 2921 PQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWlgALVPGrvaVPRFRVPQPAPSReaPASSTPPLTGHS 3000
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236 531 VPAPLAQSQQLSSHT-PVSRSSSIIQHVGLPlAPGTHSAPTSLPQSDLSQFQTQTqplvgqvddtrrkSEPLPQPPLSLI 609
Cdd:PHA03247 3001 LSRVSSWASSLALHEeTDPPPVSLKQTLWPP-DDTEDSDADSLFDSDSERSDLEA-------------LDPLPPEPHDPF 3066
|
490 500 510
....*....|....*....|....*....|....
gi 7662236 610 AeNKPVVKPPVADSLANP-LQLTPMNSLATSVFS 642
Cdd:PHA03247 3067 A-HEPDPATPEAGARESPsSQFGPPPLSANAALS 3099
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
290-619 |
1.30e-09 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 62.26 E-value: 1.30e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236 290 APLPPFPGAATGPQPMMAAAQPSQPQGAGPGGQTLPPTNVTLAQPAMSLPPQPGPAVGAPAAQQPQQFAYPQPQIPPGHL 369
Cdd:PHA03247 2574 APRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPR 2653
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236 370 LPVQPSGQSeylqQHVAGLQPPSPAQPSSTGAAASPATAATlPVGTGQNASSVGAQLMGASSQP---SEAMAPRTGPAQG 446
Cdd:PHA03247 2654 DDPAPGRVS----RPRRARRLGRAAQASSPPQRPRRRAARP-TVGSLTSLADPPPPPPTPEPAPhalVSATPLPPGPAAA 2728
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236 447 GQVAPCQP-TGVPPATVGGVVQPClGPAGAGQPQSVPPPQmgGSGPLSAVPGGPHAVVPGVPNVPAAVPAPSVPSVSTTS 525
Cdd:PHA03247 2729 RQASPALPaAPAPPAVPAGPATPG-GPARPARPPTTAGPP--APAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPA 2805
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236 526 VTMPNVPAPLAQSQQLSSHTPVSRSSSIIQHVGLPLAPGTHSAPTSL-----PQSDLSQFQTQTQPLVGQVDDTRRKSEP 600
Cdd:PHA03247 2806 DPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLggsvaPGGDVRRRPPSRSPAAKPAAPARPPVRR 2885
|
330
....*....|....*....
gi 7662236 601 LPQPPLSLIAENKPVVKPP 619
Cdd:PHA03247 2886 LARPAVSRSTESFALPPDQ 2904
|
|
| Med15 |
pfam09606 |
ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of ... |
222-596 |
2.15e-09 |
|
ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of the ARC-Mediator co-activator is a three-helix bundle with marked similarity to the KIX domain. The sterol regulatory element binding protein (SREBP) family of transcription activators use the ARC105 subunit to activate target genes in the regulation of cholesterol and fatty acid homeostasis. In addition, Med15 is a critical transducer of gene activation signals that control early metazoan development.
Pssm-ID: 312941 [Multi-domain] Cd Length: 732 Bit Score: 61.18 E-value: 2.15e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236 222 GGSVVVVVASMQGAHGPESGTDSSLTAVSQLPPsekMSQPTPAQPQSFSVGQPQPPPPPVGGAVAQSSAPLPPfpGAATG 301
Cdd:pfam09606 65 GGQGNGGMGGGQQGMPDPINALQNLAGQGTRPQ---MMGPMGPGPGGPMGQQMGGPGTASNLLASLGRPQMPM--GGAGF 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236 302 PQPMMAAaqpsqpQGAGPGGQTLPPTNVTLAQPAMSLPPQPGPAVGAPAAQ----QPQQFAYPQPQIP-----PGHLLPV 372
Cdd:pfam09606 140 PSQMSRV------GRMQPGGQAGGMMQPSSGQPGSGTPNQMGPNGGPGQGQaggmNGGQQGPMGGQMPpqmgvPGMPGPA 213
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236 373 QPSGQSEYLQQHVAGLQPPSPAQPSSTGAAASPATAAtlpvGTGQNASSVGAQLMGASSQPSEAMAPRTGPAQGGQVAPC 452
Cdd:pfam09606 214 DAGAQMGQQAQANGGMNPQQMGGAPNQVAMQQQQPQQ----QGQQSQLGMGINQMQQMPQGVGGGAGQGGPGQPMGPPGQ 289
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236 453 QPTGVPPATVGGV--------VQPCLGPAGAGQPQSVPPPQMGGSGPLSAVPGGPHAVVPGVPNVPAAVPAPSVPSVSTT 524
Cdd:pfam09606 290 QPGAMPNVMSIGDqnnyqqqqTRQQQQQQGGNHPAAHQQQMNQSVGQGGQVVALGGLNHLETWNPGNFGGLGANPMQRGQ 369
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 7662236 525 SVTMPNvPAPLAQSQQLSSHTPVSRSSSIIQHVGLPLAPGTHSAPTSLPQSDLS-QFQTQTQPLVGQVDDTRR 596
Cdd:pfam09606 370 PGMMSS-PSPVPGQQVRQVTPNQFMRQSPQPSVPSPQGPGSQPPQSHPGGMIPSpALIPSPSPQMSQQPAQQR 441
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
239-586 |
5.82e-09 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 59.78 E-value: 5.82e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236 239 ESGTDSSLTA--VSQLPPSEKMSQPTPAQPQsfsvgqpqppppPVGGAVAQSSAPLPPFPGAATGPQPMMAAAQPSQPQG 316
Cdd:pfam03154 155 ESDSDSSAQQqiLQTQPPVLQAQSGAASPPS------------PPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQ 222
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236 317 AGPGGQTLPPTNVTLAQPAMslpPQPGPAVGAPAAQQPQQFAYPQPQIPPGHLLPVQPSGQSeyLQQHVAGLQPPSPAQP 396
Cdd:pfam03154 223 STAAPHTLIQQTPTLHPQRL---PSPHPPLQPMTQPPPPSQVSPQPLPQPSLHGQMPPMPHS--LQTGPSHMQHPVPPQP 297
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236 397 SSTGAAASPATAATLPVGTGQNASSVGAQLMGASSQPSEAMAPRTGPAQGGQVA-------PCQPTGVPPATVGGVVQPC 469
Cdd:pfam03154 298 FPLTPQSSQSQVPPGPSPAAPGQSQQRIHTPPSQSQLQSQQPPREQPLPPAPLSmphikppPTTPIPQLPNPQSHKHPPH 377
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236 470 L-GPAGAGQPQSVPPPQmgGSGPLSAVPGG--PHAVVPGVPNVPAAVPAPSVPSVSTTSVTMPNVPAPLAQSQQLSSHTP 546
Cdd:pfam03154 378 LsGPSPFQMNSNLPPPP--ALKPLSSLSTHhpPSAHPPPLQLMPQSQQLPPPPAQPPVLTQSQSLPPPAASHPPTSGLHQ 455
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 7662236 547 VSRSSSIIQHVGLPLAPGTHSAPTSLPQSDLSQFQTQTQP 586
Cdd:pfam03154 456 VPSQSPFPQHPFVPGGPPPITPPSGPPTSTSSAMPGIQPP 495
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
249-625 |
5.57e-08 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 56.87 E-value: 5.57e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236 249 VSQLPPSEKMSQPTPAQPQSFSVGQPQppPPPVGGAVAQSSAPLPPFPGAATGPQPMMAAAQPSQPQGAGPGGQTLPPTN 328
Cdd:PHA03247 2479 VYRRPAEARFPFAAGAAPDPGGGGPPD--PDAPPAPSRLAPAILPDEPVGEPVHPRMLTWIRGLEELASDDAGDPPPPLP 2556
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236 329 VTLAQPAMSL---PPQPGPAVGAPAAQQPQQfaypQPQIPPGHLLPVQPSGQSEylqqHVAGLQPPSPAQPSSTGAAASP 405
Cdd:PHA03247 2557 PAAPPAAPDRsvpPPRPAPRPSEPAVTSRAR----RPDAPPQSARPRAPVDDRG----DPRGPAPPSPLPPDTHAPDPPP 2628
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236 406 ATAATLP--VGTGQNASSVGAQLMGASSQPSEAMAPRTGPAQGGQVAPCQPTGVP-----PATVGGVVQPCLGPAGAGQP 478
Cdd:PHA03247 2629 PSPSPAAnePDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPrrraaRPTVGSLTSLADPPPPPPTP 2708
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236 479 QSVPPPQMGGSgPLSAVPGGPHAVVPGVPNVPAAVPAPSVPSVSTTSVTMPNVPAPLAQSQQLSSHTPVSR-SSSIIQHV 557
Cdd:PHA03247 2709 EPAPHALVSAT-PLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGpPRRLTRPA 2787
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 7662236 558 GLPLAPGTHSAPTSlpqSDLSQFQTQTQPLVGQVDDTRRKSEPLPqPPLSLIAENKPVVKPPVADSLA 625
Cdd:PHA03247 2788 VASLSESRESLPSP---WDPADPPAAVLAPAAALPPAASPAGPLP-PPTSAQPTAPPPPPGPPPPSLP 2851
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
213-605 |
1.75e-06 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 51.53 E-value: 1.75e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236 213 ERDSGLGATGGSVVVVVASMQGAHGPESGTDSSLTAVSQLPPSEKMSQPTPAQPQSFSVGQPQPPPPPVGGAVAQSSAPL 292
Cdd:PRK07764 382 ERRLGVAGGAGAPAAAAPSAAAAAPAAAPAPAAAAPAAAAAPAPAAAPQPAPAPAPAPAPPSPAGNAPAGGAPSPPPAAA 461
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236 293 PPFPGAATGPQPMMAAAQPSQPQGAGPGGQTLPPTnvtlaqpamslPPQPGPAVGAPAAQQPQQfAYPQ-----PQI--- 364
Cdd:PRK07764 462 PSAQPAPAPAAAPEPTAAPAPAPPAAPAPAAAPAA-----------PAAPAAPAGADDAATLRE-RWPEilaavPKRsrk 529
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236 365 ------PPGHLLPVQpsGQSEYLQQHVAGLQPPSPAQPSSTGAAASPATAATLPV-------GTGQNASSVGAQLMGASS 431
Cdd:PRK07764 530 twaillPEATVLGVR--GDTLVLGFSTGGLARRFASPGNAEVLVTALAEELGGDWqveavvgPAPGAAGGEGPPAPASSG 607
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236 432 QPSEAMAPRTGPAQGGQVAPCQPTGVPPATVGGVVQPCLGPAGAGQPQSVPPPQMGGSGPLSAVPGGPHAVV-PGVPNVP 510
Cdd:PRK07764 608 PPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAAPAaPPPAPAP 687
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236 511 AAVPAPSVPSVSTTSVTMPNVPAPLAQSQQLSSHTPVSRSSSIIQHVGLPLAPgTHSAPTSLPQSDLSQFQTQTQPLVGQ 590
Cdd:PRK07764 688 AAPAAPAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSPAADDPVP-LPPEPDDPPDPAGAPAQPPPPPAPAP 766
|
410
....*....|....*
gi 7662236 591 VDDTRRKSEPLPQPP 605
Cdd:PRK07764 767 AAAPAAAPPPSPPSE 781
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
317-522 |
2.76e-06 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 51.14 E-value: 2.76e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236 317 AGPGGQTLPPTNVTLAQPAMSLPPQPGPAVGAPAAQQPQQFAYPQPQIP-PGHLLPVQPSGQSEYLQQHVAGLQPPSPAQ 395
Cdd:PRK07764 588 VGPAPGAAGGEGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPaEASAAPAPGVAAPEHHPKHVAVPDASDGGD 667
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236 396 PSSTGAAASPataatlPVGTGQNASSVGAQLMGASSQPSEAMAPRTGPAQGGQVAPCQPTGVPPATVGGVVQpclGPAGA 475
Cdd:PRK07764 668 GWPAKAGGAA------PAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSP---AADDP 738
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 7662236 476 GQPQSVPPPQMGGSGPLSAVPGGPHAVVPGVPNVPAAVPAPSVPSVS 522
Cdd:PRK07764 739 VPLPPEPDDPPDPAGAPAQPPPPPAPAPAAAPAAAPPPSPPSEEEEM 785
|
|
| PRK12323 |
PRK12323 |
DNA polymerase III subunit gamma/tau; |
306-603 |
4.23e-06 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 237057 [Multi-domain] Cd Length: 700 Bit Score: 50.26 E-value: 4.23e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236 306 MAAAQPSQpqgagPGGQTLPPTnvtlaqPAMSLPPQPGPAVGAPAAQQPQQFAYPQPQIPPghllpvqpsgqseylqqhv 385
Cdd:PRK12323 360 MLAFRPGQ-----SGGGAGPAT------AAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAA------------------- 409
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236 386 aglqPPSPAQPSSTGAAASPATAATLPVGTGQNASSVGAqlmGASSQPSEAMAPRTGPAQGGQVAPCQPTGVPPATVGGV 465
Cdd:PRK12323 410 ----PAAAAAARAVAAAPARRSPAPEALAAARQASARGP---GGAPAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAPAR 482
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236 466 VQPclGPAGAGQPQSVP-----PPQMGGSGPLSAVPGGPHAVVPGVPNvPAAVPAPSVPSVSTTSVTMPNVPAPLAQSQQ 540
Cdd:PRK12323 483 AAP--AAAPAPADDDPPpweelPPEFASPAPAQPDAAPAGWVAESIPD-PATADPDDAFETLAPAPAAAPAPRAAAATEP 559
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 7662236 541 LSSHTPVSRSSSIIQHVglpLAPGTHSAPTSLPQSDLSQFQTQTQPLVGQVDDTRRKSEPLPQ 603
Cdd:PRK12323 560 VVAPRPPRASASGLPDM---FDGDWPALAARLPVRGLAQQLARQSELAGVEGDTVRLRVPVPA 619
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
289-621 |
4.60e-06 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 50.37 E-value: 4.60e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236 289 SAPLPPFPGAATGPQPMMAAAQPSQPQGAGPGGQTLPPTNVTLAQPAMSLPPQPGPAVGAP---AAQQPQQFAYPQPQIP 365
Cdd:PRK07764 388 AGGAGAPAAAAPSAAAAAPAAAPAPAAAAPAAAAAPAPAAAPQPAPAPAPAPAPPSPAGNApagGAPSPPPAAAPSAQPA 467
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236 366 PGHLLPVQPSGQSEYlQQHVAGLQPPSPAQPSSTGAAASPATAATLP------VGTGQNASSVGAQLMGASSQ------- 432
Cdd:PRK07764 468 PAPAAAPEPTAAPAP-APPAAPAPAAAPAAPAAPAAPAGADDAATLRerwpeiLAAVPKRSRKTWAILLPEATvlgvrgd 546
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236 433 ------PSEAMAPR---------------------------TGPAQGGQVAPCQPTGVPPATVGGVVQPCLGPAGAGQPQ 479
Cdd:PRK07764 547 tlvlgfSTGGLARRfaspgnaevlvtalaeelggdwqveavVGPAPGAAGGEGPPAPASSGPPEEAARPAAPAAPAAPAA 626
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236 480 SVPPPQMGGSGPLSAVPGGPHAVVPGVPNVPAAVPAPSVPSVSTTSVTMPNVPAPLAQSQQLSSHTPVSRSSSIiqhvgl 559
Cdd:PRK07764 627 PAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQ------ 700
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 7662236 560 PLAPGTHSAPTSLPQSDLSQFQTQTQPLVGQVDDTRRKSEPLPQPPLSLIAENKPVVKPPVA 621
Cdd:PRK07764 701 PAPAPAATPPAGQADDPAAQPPQAAQGASAPSPAADDPVPLPPEPDDPPDPAGAPAQPPPPP 762
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
253-445 |
8.58e-06 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 49.21 E-value: 8.58e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236 253 PPSEKMSQPTPAQPQSFSVGQPQPPPPPVGGAVAQSSAPLPPFPGAATGPQPMMAAAQPSQPQGAGPGGQTLPPTNVTLA 332
Cdd:PRK07764 602 APASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAAPAAP 681
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236 333 QPAMSLPPQPGPAVGAPAAQQPQQFAYPQPQIPPGHLLPVQPSGQSEYLQQHVAGLQPPSPAQPSSTGAAASPATAATLP 412
Cdd:PRK07764 682 PPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSPAADDPVPLPPEPDDPPDPAGAPAQPPPP 761
|
170 180 190
....*....|....*....|....*....|...
gi 7662236 413 VGTGQNASSVGAQLMGASSQPSEAMAPRTGPAQ 445
Cdd:PRK07764 762 PAPAPAAAPAAAPPPSPPSEEEEMAEDDAPSMD 794
|
|
| PRK10263 |
PRK10263 |
DNA translocase FtsK; Provisional |
289-484 |
1.90e-05 |
|
DNA translocase FtsK; Provisional
Pssm-ID: 236669 [Multi-domain] Cd Length: 1355 Bit Score: 48.54 E-value: 1.90e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236 289 SAPLPPFPGAATGPQPMMAAAQPSQPQGAGPGGQTLPptnvtlAQPAMSLPPQPGPAVGAPA-AQQPQQFAyPQPQIPPg 367
Cdd:PRK10263 317 TEPVAVAAAATTATQSWAAPVEPVTQTPPVASVDVPP------AQPTVAWQPVPGPQTGEPViAPAPEGYP-QQSQYAQ- 388
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236 368 hllpvQPSGQSEYLQQhvaglqppsPAQPSSTGAAASPATAATLPVGTGQNASSVGAQLMGASSQPSEAMAPRTGPAQGG 447
Cdd:PRK10263 389 -----PAVQYNEPLQQ---------PVQPQQPYYAPAAEQPAQQPYYAPAPEQPAQQPYYAPAPEQPVAGNAWQAEEQQS 454
|
170 180 190
....*....|....*....|....*....|....*..
gi 7662236 448 QVAPcQPTGVPPATvggVVQPCLGPAGAGQPQSVPPP 484
Cdd:PRK10263 455 TFAP-QSTYQTEQT---YQQPAAQEPLYQQPQPVEQQ 487
|
|
| PRK12323 |
PRK12323 |
DNA polymerase III subunit gamma/tau; |
240-460 |
3.13e-05 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 237057 [Multi-domain] Cd Length: 700 Bit Score: 47.56 E-value: 3.13e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236 240 SGTDSSLTAVSQLPpsekMSQPTPAQPQSFSVGQPQPPPPPVGGAVAQSSAPLPPFPGAATGPQPMMAAAQPSQPQGAGP 319
Cdd:PRK12323 368 SGGGAGPATAAAAP----VAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARG 443
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236 320 GGQTLPPTNVTLAQPAMSLPPQPGPAVGAPAA-------QQPQQFAYPQPQ-IPPGHLLPVQPSgqseylqqhVAGLQPP 391
Cdd:PRK12323 444 PGGAPAPAPAPAAAPAAAARPAAAGPRPVAAAaaaaparAAPAAAPAPADDdPPPWEELPPEFA---------SPAPAQP 514
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 7662236 392 SPAQPSSTGAAASPATAATLPVGTGQNASSVGAQLMGASSQPSEAMAPRTGPAQGGQVAPCQPTGVPPA 460
Cdd:PRK12323 515 DAAPAGWVAESIPDPATADPDDAFETLAPAPAAAPAPRAAAATEPVVAPRPPRASASGLPDMFDGDWPA 583
|
|
| PAT1 |
pfam09770 |
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ... |
238-432 |
3.19e-05 |
|
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.
Pssm-ID: 401645 [Multi-domain] Cd Length: 846 Bit Score: 47.72 E-value: 3.19e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236 238 PESGTDSSLTAVSQLPPSEKM-----------SQPTPAQPQSFSVGQPQPPPPPVGGAVAQSSAPLPPfpgaatgPQPMM 306
Cdd:pfam09770 173 PAPAPQPAAQPASLPAPSRKMmsleeveaamrAQAKKPAQQPAPAPAQPPAAPPAQQAQQQQQFPPQI-------QQQQQ 245
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236 307 AAAQPSQPQGagPGGQTLPPTNVTLAQpamSLPPQPGPAVGAPAAQQPQQFAYPQPQiPPGHLLPvQPSGQSEYLQQHVA 386
Cdd:pfam09770 246 PQQQPQQPQQ--HPGQGHPVTILQRPQ---SPQPDPAQPSIQPQAQQFHQQPPPVPV-QPTQILQ-NPNRLSAARVGYPQ 318
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 7662236 387 GLQPPSPAQPSSTGAAASPATAATLPVGTGQnassvgAQLMGASSQ 432
Cdd:pfam09770 319 NPQPGVQPAPAHQAHRQQGSFGRQAPIITHP------QQLAQLSEE 358
|
|
| PRK10263 |
PRK10263 |
DNA translocase FtsK; Provisional |
289-534 |
4.41e-05 |
|
DNA translocase FtsK; Provisional
Pssm-ID: 236669 [Multi-domain] Cd Length: 1355 Bit Score: 47.39 E-value: 4.41e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236 289 SAPLPPFPGAATGPQPMMAAAQPSQPQGAGPGGQTLPPtnvTLAQPAMSLPPQPGPAVGAPAAQQPQQFAYPqPQIPPGH 368
Cdd:PRK10263 334 AAPVEPVTQTPPVASVDVPPAQPTVAWQPVPGPQTGEP---VIAPAPEGYPQQSQYAQPAVQYNEPLQQPVQ-PQQPYYA 409
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236 369 LLPVQPSGQSEYLQQHVAGLQPPSPA-QPSSTGAAASPATAATLPVGTGQNASSVGAQLMGASSQPSEAMAPRTGPaqgg 447
Cdd:PRK10263 410 PAAEQPAQQPYYAPAPEQPAQQPYYApAPEQPVAGNAWQAEEQQSTFAPQSTYQTEQTYQQPAAQEPLYQQPQPVE---- 485
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236 448 qvapcQPTGVPPATVGGVVQPCLGPAG----------------AGQPQSVPPPQMGGSGPLSAVPGGPHAVVPGVPNVPA 511
Cdd:PRK10263 486 -----QQPVVEPEPVVEETKPARPPLYyfeeveekrarereqlAAWYQPIPEPVKEPEPIKSSLKAPSVAAVPPVEAAAA 560
|
250 260
....*....|....*....|....
gi 7662236 512 AVP-APSVPSVSTTSVTMPNVPAP 534
Cdd:PRK10263 561 VSPlASGVKKATLATGAAATVAAP 584
|
|
| ZIP_MycBP-like |
cd21937 |
leucine zipper domain found in c-Myc-binding protein and similar proteins; MycBP, also called ... |
693-745 |
5.65e-05 |
|
leucine zipper domain found in c-Myc-binding protein and similar proteins; MycBP, also called associate of Myc 1 (AMY-1), is a novel c-Myc binding protein that may control the transcriptional activity of Myc. It stimulates the activation of E box-dependent transcription by Myc. This model corresponds to the conserved region that shows high sequence similarity with the leucine zipper (ZIP) domain located at the C-terminus of TGF-beta-stimulated clone-22 domain (TSC22D) family transcription factors. The first helix of ZIP is not basic and does not contain the consensus sequence, NXX(A)(A)XX(C/S)R, found in most basic region/leucine zipper (bZIP) proteins. Thus, the DNA-binding capability of the ZIP domain is not obvious. Similar to bZIP, ZIP forms homo- and heterodimers, resulting in many dimers that may have different effects on transcription.
Pssm-ID: 409277 [Multi-domain] Cd Length: 53 Bit Score: 41.38 E-value: 5.65e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 7662236 693 AMDLVKSHL--MYAVREEVEVLKEQIKELVERNSLLERENALLKSlssndQLSQL 745
Cdd:cd21937 3 ALDFIKQHLgaPGPEDADVEALRLENEELKQKNEELEEENKELKA-----KLQQY 52
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
321-658 |
1.28e-04 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 45.70 E-value: 1.28e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236 321 GQTLPPTNVTLAQPAMSLPPQPGPAVGAPAAQQPQQFAYPQPQIPPGHLLPVQPSGQS-------------EYLQQHVAG 387
Cdd:PHA03247 2471 GELFPGAPVYRRPAEARFPFAAGAAPDPGGGGPPDPDAPPAPSRLAPAILPDEPVGEPvhprmltwirgleELASDDAGD 2550
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236 388 LQPPSPAQPSSTGAAASPATAATLPVGTGQNASSVGAQlMGASSQPSEAMAPRTGPaqGGQVAPCQPTGVPPATVGGVVQ 467
Cdd:PHA03247 2551 PPPPLPPAAPPAAPDRSVPPPRPAPRPSEPAVTSRARR-PDAPPQSARPRAPVDDR--GDPRGPAPPSPLPPDTHAPDPP 2627
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236 468 PCLGPAGAGQPQSVPPPQMGGSGPLSAVPGGPHAVVPGVPNVPAAVPAPSVPSVSTTSVTMPNVPAPLAQSQQLSSHTPV 547
Cdd:PHA03247 2628 PPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPT 2707
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236 548 SRSSSIIQHVGLPLAPGTHSAPTSLPQSDLSQFQTQT-QPLVGQVDDTRRKSEPLPQPPLSLIAENKPVVKPPVAdslan 626
Cdd:PHA03247 2708 PEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVpAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRR----- 2782
|
330 340 350
....*....|....*....|....*....|..
gi 7662236 627 pLQLTPMNSLATSVFSIAIPVDGDEDRNPSTA 658
Cdd:PHA03247 2783 -LTRPAVASLSESRESLPSPWDPADPPAAVLA 2813
|
|
| PRK07003 |
PRK07003 |
DNA polymerase III subunit gamma/tau; |
295-540 |
1.79e-04 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 235906 [Multi-domain] Cd Length: 830 Bit Score: 45.23 E-value: 1.79e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236 295 FPGAATGPQPMMAAAQPSQPQGAGPGGQTLPPTNVTLAQPAMslPPQPGPAVGAPAAQQPQQFAYPQPQIPPGHLLPVQP 374
Cdd:PRK07003 358 FEPAVTGGGAPGGGVPARVAGAVPAPGARAAAAVGASAVPAV--TAVTGAAGAALAPKAAAAAAATRAEAPPAAPAPPAT 435
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236 375 SGQSEylqqhvAGLQPPSPAQPSSTGAAASPATAATLPvgtGQNASSVGAQLMGASSQPSEAMAPRTGPAqgGQVAPCQP 454
Cdd:PRK07003 436 ADRGD------DAADGDAPVPAKANARASADSRCDERD---AQPPADSGSASAPASDAPPDAAFEPAPRA--AAPSAATP 504
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236 455 TGVPPATVGGVVQPCLGPAgagqPQSVPPPQMGGSGPLSAVP----GGPHAVV------------------PGVPNVPAA 512
Cdd:PRK07003 505 AAVPDARAPAAASREDAPA----AAAPPAPEARPPTPAAAAPaaraGGAAAALdvlrnagmrvssdrgaraAAAAKPAAA 580
|
250 260
....*....|....*....|....*...
gi 7662236 513 VPAPSVPSVSTTSVTMPNVPAPLAQSQQ 540
Cdd:PRK07003 581 PAAAPKPAAPRVAVQVPTPRARAATGDA 608
|
|
| PRK07003 |
PRK07003 |
DNA polymerase III subunit gamma/tau; |
306-550 |
2.31e-04 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 235906 [Multi-domain] Cd Length: 830 Bit Score: 44.84 E-value: 2.31e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236 306 MAAAQPSQPQGAGPGGQTlpptnvtlaqpamslPPQPGPAVGAPAAQQPQqfaypqpqippghllpvqpsgqseylqqhV 385
Cdd:PRK07003 355 MLAFEPAVTGGGAPGGGV---------------PARVAGAVPAPGARAAA-----------------------------A 390
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236 386 AGLQPPSPAQPSSTGAAASPATAATLPVGTGQNASSVGAQLMGASSQPSEAMAPRTGPAQGGQVAPCQPTGVPPATvggV 465
Cdd:PRK07003 391 VGASAVPAVTAVTGAAGAALAPKAAAAAAATRAEAPPAAPAPPATADRGDDAADGDAPVPAKANARASADSRCDER---D 467
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236 466 VQPCLGPA-GAGQPQSVPPPQMGGSGPLSAVPGGPHAVVPGVPNVPAAVPAPSVPSvsttsvtMPNVPAPLAQSQQLSSH 544
Cdd:PRK07003 468 AQPPADSGsASAPASDAPPDAAFEPAPRAAAPSAATPAAVPDARAPAAASREDAPA-------AAAPPAPEARPPTPAAA 540
|
....*.
gi 7662236 545 TPVSRS 550
Cdd:PRK07003 541 APAARA 546
|
|
| PRK07003 |
PRK07003 |
DNA polymerase III subunit gamma/tau; |
438-627 |
2.50e-04 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 235906 [Multi-domain] Cd Length: 830 Bit Score: 44.46 E-value: 2.50e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236 438 APRTGPAQGGQVAPCQPTGVPPAtvggvvqpclGPAGAGQPQSVPPPQMGGSGPLSAVPGGPHAVVPGVPNVPAAVPAPS 517
Cdd:PRK07003 361 AVTGGGAPGGGVPARVAGAVPAP----------GARAAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATRAEAPPAAP 430
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236 518 VPSVSTTSVTMPNVPAPLAQSQQLSSHTPVSRSSSiiqhvgLPLAPGTHSAPTSLPQSDLSQFQT-QTQPLVGQVDDTRR 596
Cdd:PRK07003 431 APPATADRGDDAADGDAPVPAKANARASADSRCDE------RDAQPPADSGSASAPASDAPPDAAfEPAPRAAAPSAATP 504
|
170 180 190
....*....|....*....|....*....|.
gi 7662236 597 KSEPLPQPPLSLIAENKPVVKPPVADSLANP 627
Cdd:PRK07003 505 AAVPDARAPAAASREDAPAAAAPPAPEARPP 535
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
297-605 |
2.69e-04 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 44.59 E-value: 2.69e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236 297 GAATGPQPMMAAAQPSQPQGAGPGGQTLPPTNVTLAQPAMSLPPQPGPAVGAPAAQQPQQfAYPQPQIPPGHLLPVQPSG 376
Cdd:PRK07764 365 PSASDDERGLLARLERLERRLGVAGGAGAPAAAAPSAAAAAPAAAPAPAAAAPAAAAAPA-PAAAPQPAPAPAPAPAPPS 443
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236 377 QSEYLQQHVAGLQPPSPAQPSStgaaaspataatlPVGTGQNASSVGAQlmgASSQPSEAMAPRTGPAQGGQVAPCQPTG 456
Cdd:PRK07764 444 PAGNAPAGGAPSPPPAAAPSAQ-------------PAPAPAAAPEPTAA---PAPAPPAAPAPAAAPAAPAAPAAPAGAD 507
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236 457 ---------------------------VPPATVGGVVQPCL--------------------------------------- 470
Cdd:PRK07764 508 daatlrerwpeilaavpkrsrktwailLPEATVLGVRGDTLvlgfstgglarrfaspgnaevlvtalaeelggdwqveav 587
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236 471 --GPAGAGQPQSVPPPQMGGSGPLSAVPGGP-HAVVPGVPNVPAAVPAPSVPSVSTTSVTMPNVPAPLAQSQQLSSHTPV 547
Cdd:PRK07764 588 vgPAPGAAGGEGPPAPASSGPPEEAARPAAPaAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGD 667
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 7662236 548 SRSSSIIQHVGLPLAPGTHSAPtslPQSDLSQFQTQTQPLVGQVDDTRRKSEPLPQPP 605
Cdd:PRK07764 668 GWPAKAGGAAPAAPPPAPAPAA---PAAPAGAAPAQPAPAPAATPPAGQADDPAAQPP 722
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
307-521 |
3.76e-04 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 44.21 E-value: 3.76e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236 307 AAAQPSQPQGAGPGGQTLPPTNVTLAQPAMSLPP--QPGPAVGAPAAQQPQQFAYPQPQIPPGHLLPVQPSGQSEYLQQH 384
Cdd:PRK07764 588 VGPAPGAAGGEGPPAPASSGPPEEAARPAAPAAPaaPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGD 667
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236 385 VAGLQPPSPAQPSSTGAAASPATAATLPVGTGQNASSVGAQLMGASSQpSEAMAPRTGPAQGGQVAPCQPTGVPPATvgg 464
Cdd:PRK07764 668 GWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQAD-DPAAQPPQAAQGASAPSPAADDPVPLPP--- 743
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 7662236 465 vvQPCLGPAGAGQPQSVPPPQMGGSGPLSAVPGGPHAVVPGVPNVPAAVPAPSVPSV 521
Cdd:PRK07764 744 --EPDDPPDPAGAPAQPPPPPAPAPAAAPAAAPPPSPPSEEEEMAEDDAPSMDDEDR 798
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
209-366 |
5.24e-04 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 43.44 E-value: 5.24e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236 209 DQTAERDSGLGATGGSVVVVVASMQGAHGPESGTDSSLTaVSQLPPSEKMSQPTPAQPQSFSVGQPQPPPPPVGGAVAQS 288
Cdd:PRK07764 627 PAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDG-GDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAP 705
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236 289 SAPLPPFPGAATGPQPMMAAAQPSQPQGAGPGGQTLPPT---NVTLAQPAMSLPPQPGPAVGAPAAQQPQQFAYPQPQIP 365
Cdd:PRK07764 706 AATPPAGQADDPAAQPPQAAQGASAPSPAADDPVPLPPEpddPPDPAGAPAQPPPPPAPAPAAAPAAAPPPSPPSEEEEM 785
|
.
gi 7662236 366 P 366
Cdd:PRK07764 786 A 786
|
|
| PRK14971 |
PRK14971 |
DNA polymerase III subunit gamma/tau; |
232-356 |
5.83e-04 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 237874 [Multi-domain] Cd Length: 614 Bit Score: 43.23 E-value: 5.83e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236 232 MQGAHGPESGTDSSLTAVSQLPPSEKMSQPTPAQPQSfsVGQPQPPPPPVGGAVAQSSAPlPPFPGAATGPQPM---MAA 308
Cdd:PRK14971 357 IQLAQLTQKGDDASGGRGPKQHIKPVFTQPAAAPQPS--AAAAASPSPSQSSAAAQPSAP-QSATQPAGTPPTVsvdPPA 433
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 7662236 309 AQPSQPQGAGPgGQTLPPTNVTLAQPAMSLPPQPGPAVGAPAAQQPQQ 356
Cdd:PRK14971 434 AVPVNPPSTAP-QAVRPAQFKEEKKIPVSKVSSLGPSTLRPIQEKAEQ 480
|
|
| PRK07003 |
PRK07003 |
DNA polymerase III subunit gamma/tau; |
287-543 |
6.48e-04 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 235906 [Multi-domain] Cd Length: 830 Bit Score: 43.30 E-value: 6.48e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236 287 QSSAPLPPFPGAATGPQPMMAAAQPSQPQGAGPGGQTLPPtnvtlAQPAMSLPPQPGPAVGAPAAQQ-PQQFAYPQPQIP 365
Cdd:PRK07003 385 ARAAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATRAE-----APPAAPAPPATADRGDDAADGDaPVPAKANARASA 459
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236 366 PGHLLPVQPSGQSEYLQQhvAGLQPPSPAQPSSTGAAASPATAATLPVGTGQNASSVGAQLMGASSQPSEAmAPRTGPAQ 445
Cdd:PRK07003 460 DSRCDERDAQPPADSGSA--SAPASDAPPDAAFEPAPRAAAPSAATPAAVPDARAPAAASREDAPAAAAPP-APEARPPT 536
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236 446 GGQVApcqptgvPPATVGGVVQPCLGPAGAGQPQSVPPPQMGGSGPLSAVPgGPHAVVPGVPNVPAAVPAPSVPSVSTTS 525
Cdd:PRK07003 537 PAAAA-------PAARAGGAAAALDVLRNAGMRVSSDRGARAAAAAKPAAA-PAAAPKPAAPRVAVQVPTPRARAATGDA 608
|
250
....*....|....*...
gi 7662236 526 VTMPNVPAPLAQSQQLSS 543
Cdd:PRK07003 609 PPNGAARAEQAAESRGAP 626
|
|
| PABP-1234 |
TIGR01628 |
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ... |
296-378 |
1.04e-03 |
|
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.
Pssm-ID: 130689 [Multi-domain] Cd Length: 562 Bit Score: 42.49 E-value: 1.04e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236 296 PGAATGPQPMMAAAQPSQPQGAGPGGQTLPPTNVTL---------AQPAMSLPPQPGPAVGAPAAQQPQQFAYPQPQIPP 366
Cdd:TIGR01628 405 PQQQFNGQPLGWPRMSMMPTPMGPGGPLRPNGLAPMnavrapsrnAQNAAQKPPMQPVMYPPNYQSLPLSQDLPQPQSTA 484
|
90
....*....|..
gi 7662236 367 GHLLPVQPSGQS 378
Cdd:TIGR01628 485 SQGGQNKKLAQV 496
|
|
| PHA03378 |
PHA03378 |
EBNA-3B; Provisional |
311-520 |
1.19e-03 |
|
EBNA-3B; Provisional
Pssm-ID: 223065 [Multi-domain] Cd Length: 991 Bit Score: 42.36 E-value: 1.19e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236 311 PSQPQGAGPGGQTLPPTNVTLAQPAMSLPPQPGPAVGAPAAQQPqqfaypqPQIPPGHLLPVQPSGQSEYLQQHVAGLQP 390
Cdd:PHA03378 673 PYQPSPTGANTMLPIQWAPGTMQPPPRAPTPMRPPAAPPGRAQR-------PAAATGRARPPAAAPGRARPPAAAPGRAR 745
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236 391 PSPAQPSSTGAAASPATAATLPVGT-GQNASSVGAQLMGASSQPSEAMAPRTGPAQGG----QVAPCQPTGVPPATVGGV 465
Cdd:PHA03378 746 PPAAAPGRARPPAAAPGRARPPAAApGAPTPQPPPQAPPAPQQRPRGAPTPQPPPQAGptsmQLMPRAAPGQQGPTKQIL 825
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 7662236 466 VQPCLGPAGAGQPQSVPPPQMGGSGPLSAVPGGPHAVVPGVPNVPAAVPAPSVPS 520
Cdd:PHA03378 826 RQLLTGGVKRGRPSLKKPAALERQAAAGPTPSPGSGTSDKIVQAPVFYPPVLQPI 880
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
244-552 |
1.22e-03 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 42.45 E-value: 1.22e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236 244 SSLTAVSQLPPSEKMSQPTPAQPQSfsvGQPQPPPPPVGGAVAQSSA----PLPPFPGAATGPQPMMAAAQPSQPQGAGP 319
Cdd:pfam03154 226 APHTLIQQTPTLHPQRLPSPHPPLQ---PMTQPPPPSQVSPQPLPQPslhgQMPPMPHSLQTGPSHMQHPVPPQPFPLTP 302
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236 320 G---GQTLPPTNVTLAQPAMSLPPQPGPAVGAPAAQQPQQ-------FAYPQPQIPPGHLLPVQPSGQSeylQQHVAGLQ 389
Cdd:pfam03154 303 QssqSQVPPGPSPAAPGQSQQRIHTPPSQSQLQSQQPPREqplppapLSMPHIKPPPTTPIPQLPNPQS---HKHPPHLS 379
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236 390 PPSPAQ-PSSTGAAASPATAATLPVGTGQNASSVGAQLMGASSQPSEAMAPRTGPAQGGQVAPCQPTGVPPATVGGVVQP 468
Cdd:pfam03154 380 GPSPFQmNSNLPPPPALKPLSSLSTHHPPSAHPPPLQLMPQSQQLPPPPAQPPVLTQSQSLPPPAASHPPTSGLHQVPSQ 459
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236 469 CLGPAGAGQPQSVPPPQMGGSGPLSAVPGGPHAVVPGVPNVPAAVPAPSVPSVSTTSVTMPNvpAPLAQSQQLSSHTPVS 548
Cdd:pfam03154 460 SPFPQHPFVPGGPPPITPPSGPPTSTSSAMPGIQPPSSASVSSSGPVPAAVSCPLPPVQIKE--EALDEAEEPESPPPPP 537
|
....
gi 7662236 549 RSSS 552
Cdd:pfam03154 538 RSPS 541
|
|
| PRK14951 |
PRK14951 |
DNA polymerase III subunits gamma and tau; Provisional |
429-586 |
1.23e-03 |
|
DNA polymerase III subunits gamma and tau; Provisional
Pssm-ID: 237865 [Multi-domain] Cd Length: 618 Bit Score: 42.39 E-value: 1.23e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236 429 ASSQPSEAMAPRTGPAQGGQVAPCqPTGVPPATVGGVVQPclGPAGAGQPQSVPPPqmggsgplsavpggphAVVPGVPN 508
Cdd:PRK14951 367 AAAAEAAAPAEKKTPARPEAAAPA-AAPVAQAAAAPAPAA--APAAAASAPAAPPA----------------AAPPAPVA 427
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 7662236 509 VPAAVPAPSVPSVSTTSVTMPnvPAPLAQSQQLSSHTPVsRSSSIIQHVGLPLAPGTHSAPTSLPQSDLSQFQTQTQP 586
Cdd:PRK14951 428 APAAAAPAAAPAAAPAAVALA--PAPPAQAAPETVAIPV-RVAPEPAVASAAPAPAAAPAAARLTPTEEGDVWHATVQ 502
|
|
| PRK10263 |
PRK10263 |
DNA translocase FtsK; Provisional |
251-396 |
1.25e-03 |
|
DNA translocase FtsK; Provisional
Pssm-ID: 236669 [Multi-domain] Cd Length: 1355 Bit Score: 42.38 E-value: 1.25e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236 251 QLPPSEKMSQPTPAQPQSFSVGQPQPPPPPVGGAVAQSSAPLPPFPGAATGPQPMMAAAQPSQ----PQGAGPGGQTLPP 326
Cdd:PRK10263 728 EFSPMKALLDDGPHEPLFTPIVEPVQQPQQPVAPQQQYQQPQQPVAPQPQYQQPQQPVAPQPQyqqpQQPVAPQPQYQQP 807
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 7662236 327 TNVTLAQPAMSLPPQPgpAVGAPAAQQPQQFAYPQPQIPPGHLLPVQpSGQSEYLQQHVAGL-------QPPSPAQP 396
Cdd:PRK10263 808 QQPVAPQPQYQQPQQP--VAPQPQYQQPQQPVAPQPQDTLLHPLLMR-NGDSRPLHKPTTPLpsldlltPPPSEVEP 881
|
|
| PHA03378 |
PHA03378 |
EBNA-3B; Provisional |
294-499 |
1.55e-03 |
|
EBNA-3B; Provisional
Pssm-ID: 223065 [Multi-domain] Cd Length: 991 Bit Score: 41.98 E-value: 1.55e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236 294 PFPGAATGPQPMMAAAQPSQPQGAGPGGQTLPPTNVTLAQPAMSLPPQPGPAVGAPAAQQPQQFA---YPQPQIPPGHLL 370
Cdd:PHA03378 696 PPPRAPTPMRPPAAPPGRAQRPAAATGRARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAApgrARPPAAAPGAPT 775
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236 371 PVQPSGQSEYLQQHVAGlqPPSPAQPSSTGAAASPATAATLPVGTGQNASSVGAQLMGASSQPSEAMAPrtgPAQGGQVA 450
Cdd:PHA03378 776 PQPPPQAPPAPQQRPRG--APTPQPPPQAGPTSMQLMPRAAPGQQGPTKQILRQLLTGGVKRGRPSLKK---PAALERQA 850
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 7662236 451 PCQPTGVPPATVGG-VVQPCLGPAGAGQPQSVpPPQMGGSGPL--SAVPGGP 499
Cdd:PHA03378 851 AAGPTPSPGSGTSDkIVQAPVFYPPVLQPIQV-MRQLGSVRAAaaSTVTQAP 901
|
|
| PHA03378 |
PHA03378 |
EBNA-3B; Provisional |
296-639 |
1.57e-03 |
|
EBNA-3B; Provisional
Pssm-ID: 223065 [Multi-domain] Cd Length: 991 Bit Score: 41.98 E-value: 1.57e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236 296 PGAATGPQPMmaaAQPSQPQGaGPGGQTLPPTNVTLAQPAMSLPPQPGpavgAPAAQQPQQFAypqpqiPPGHLLPVQPS 375
Cdd:PHA03378 590 PSYAQTPWPV---PHPSQTPE-PPTTQSHIPETSAPRQWPMPLRPIPM----RPLRMQPITFN------VLVFPTPHQPP 655
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236 376 GQSEYLQQHVAGLQPPSPAQPSstgaaaspataatlpvgTGQNASSVGAQLMGASSQPSEAMAPRTGPAQGGQVAPCQPT 455
Cdd:PHA03378 656 QVEITPYKPTWTQIGHIPYQPS-----------------PTGANTMLPIQWAPGTMQPPPRAPTPMRPPAAPPGRAQRPA 718
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236 456 GVPPATVGGVVQPCLGPAGAGQPQSVPPPQM--GGSGPLSAVPGgPHAVVPGVPNVPAAVPAPSVPsvsttsvtmpnvPA 533
Cdd:PHA03378 719 AATGRARPPAAAPGRARPPAAAPGRARPPAAapGRARPPAAAPG-RARPPAAAPGAPTPQPPPQAP------------PA 785
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236 534 PLAQSQQLSSHTPVSRSSSIIQHVGLPLAPGTHSAPTSLPQSDLSQFQTQTQPLVGQVDDTRRKS----EPLPQPPLSLI 609
Cdd:PHA03378 786 PQQRPRGAPTPQPPPQAGPTSMQLMPRAAPGQQGPTKQILRQLLTGGVKRGRPSLKKPAALERQAaagpTPSPGSGTSDK 865
|
330 340 350
....*....|....*....|....*....|
gi 7662236 610 AENKPVVKPPVADSLANPLQLTPMNSLATS 639
Cdd:PHA03378 866 IVQAPVFYPPVLQPIQVMRQLGSVRAAAAS 895
|
|
| PRK13169 |
PRK13169 |
DNA replication initiation control protein YabA; |
707-759 |
2.77e-03 |
|
DNA replication initiation control protein YabA;
Pssm-ID: 183876 Cd Length: 110 Bit Score: 38.30 E-value: 2.77e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 7662236 707 EEVEVLKEQIKELVERNSLLERENALLKslssnDQLSQLpTQQANPGSTSQQQ 759
Cdd:PRK13169 22 KELGALKKQLAELLEENTALRLENDKLR-----ERLEEL-EAEEPAKEKKKKE 68
|
|
| ZapB |
pfam06005 |
Cell division protein ZapB; ZapB is a non-essential, abundant cell division factor that is ... |
707-749 |
3.21e-03 |
|
Cell division protein ZapB; ZapB is a non-essential, abundant cell division factor that is required for proper Z-ring formation.
Pssm-ID: 428718 [Multi-domain] Cd Length: 71 Bit Score: 36.86 E-value: 3.21e-03
10 20 30 40
....*....|....*....|....*....|....*....|...
gi 7662236 707 EEVEVLKEQIKELVERNSLLERENALLKslSSNDQLSQLPTQQ 749
Cdd:pfam06005 18 DTIALLQMENEELKEENEELKEEANELE--EENQQLKQERNQW 58
|
|
| PHA03378 |
PHA03378 |
EBNA-3B; Provisional |
261-485 |
3.52e-03 |
|
EBNA-3B; Provisional
Pssm-ID: 223065 [Multi-domain] Cd Length: 991 Bit Score: 40.82 E-value: 3.52e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236 261 PTPAQPQSFSVGQPQPPPPPVGGAVAQSSAP--LPPFPGAATGPQPMMAAAQPSQPQGAGPGgqTLPPTNVTLAQPAMSL 338
Cdd:PHA03378 701 PTPMRPPAAPPGRAQRPAAATGRARPPAAAPgrARPPAAAPGRARPPAAAPGRARPPAAAPG--RARPPAAAPGAPTPQP 778
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236 339 PPQPGPAvgapAAQQPQQFAYPQ--PQIPPG--HLLPVQPSGQSEYLQQHVAGLQPPSPAQPSSTGAAASPATAATLPVG 414
Cdd:PHA03378 779 PPQAPPA----PQQRPRGAPTPQppPQAGPTsmQLMPRAAPGQQGPTKQILRQLLTGGVKRGRPSLKKPAALERQAAAGP 854
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 7662236 415 TGQNASSVGAQLMGASSQPSEAMAPRTGPAQGGQVAPCQPTGVPPATVGGVVQPCLGpaGAGQPQSVPPPQ 485
Cdd:PHA03378 855 TPSPGSGTSDKIVQAPVFYPPVLQPIQVMRQLGSVRAAAASTVTQAPTEYTGERRGV--GPMHPTDIPPSK 923
|
|
| PRK07994 |
PRK07994 |
DNA polymerase III subunits gamma and tau; Validated |
475-648 |
4.58e-03 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236138 [Multi-domain] Cd Length: 647 Bit Score: 40.62 E-value: 4.58e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236 475 AGQPQSVPPPQMGGSGPLSAVPGGPHAVVPGVPNVPAAVPAPSVPSVSTTSVTMPNVPAPLAQSQQLSSHTPVSRSSSIi 554
Cdd:PRK07994 363 APLPEPEVPPQSAAPAASAQATAAPTAAVAPPQAPAVPPPPASAPQQAPAVPLPETTSQLLAARQQLQRAQGATKAKKS- 441
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236 555 qhvgLPLAPGThSAPTSLPQSDLSQFQTQTQPLVGQVDdtrrKSEPLPQPPLSLIAENKPVVKPPVAdsLANPLQLTPMN 634
Cdd:PRK07994 442 ----EPAAASR-ARPVNSALERLASVRPAPSALEKAPA----KKEAYRWKATNPVEVKKEPVATPKA--LKKALEHEKTP 510
|
170
....*....|....
gi 7662236 635 SLATSVFSIAIPVD 648
Cdd:PRK07994 511 ELAAKLAAEAIERD 524
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
287-649 |
4.86e-03 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 40.52 E-value: 4.86e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236 287 QSSAPLPPFPGAATGPQPMMAAAQPSQPQGAGPGGQTLPPTNVTLAQPAMSLPPQPGPAVGAPAAqqPQQFAYPQPQIPP 366
Cdd:pfam03154 142 RSTSPSIPSPQDNESDSDSSAQQQILQTQPPVLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSV--PPQGSPATSQPPN 219
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236 367 GHLLPVQPSGqseyLQQHVAGLQPPSPAQPSSTGAAASPataatlPVGTGQNASSVGAQLMGASSQPSEAMAPRTGPAQG 446
Cdd:pfam03154 220 QTQSTAAPHT----LIQQTPTLHPQRLPSPHPPLQPMTQ------PPPPSQVSPQPLPQPSLHGQMPPMPHSLQTGPSHM 289
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236 447 GQVAPCQPTGVPPATVGGVVQPCLGPAGAGQPQSVPPPQMGGSGPLSAVPGGPHAVVPGVPNVPAAVPAPSVPsvsttsv 526
Cdd:pfam03154 290 QHPVPPQPFPLTPQSSQSQVPPGPSPAAPGQSQQRIHTPPSQSQLQSQQPPREQPLPPAPLSMPHIKPPPTTP------- 362
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236 527 tMPNVPAPLAQSQ--QLSSHTPVSRSSSIIQHVGL-PLA-------PGTHSAPTSL-PQSDLSQ---------FQTQTQP 586
Cdd:pfam03154 363 -IPQLPNPQSHKHppHLSGPSPFQMNSNLPPPPALkPLSslsthhpPSAHPPPLQLmPQSQQLPpppaqppvlTQSQSLP 441
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 7662236 587 LVGQVDDTRRKSEPLPQ----PPLSLIAENKPVVKPPVADSLANPLQLTPMNSLATSVFSIAIPVDG 649
Cdd:pfam03154 442 PPAASHPPTSGLHQVPSqspfPQHPFVPGGPPPITPPSGPPTSTSSAMPGIQPPSSASVSSSGPVPA 508
|
|
| PAT1 |
pfam09770 |
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ... |
300-486 |
6.03e-03 |
|
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.
Pssm-ID: 401645 [Multi-domain] Cd Length: 846 Bit Score: 40.02 E-value: 6.03e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236 300 TGPQPMMAAAQPSQPQGAGPGGQTLPPTNVTL--AQPAMSLPPQPgpavgapAAQQPQQFAYPQPQIPPGH--------- 368
Cdd:pfam09770 165 VAPKKAAAPAPAPQPAAQPASLPAPSRKMMSLeeVEAAMRAQAKK-------PAQQPAPAPAQPPAAPPAQqaqqqqqfp 237
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236 369 ---LLPVQPSGQSEYLQQHVAGLQPPSPAQ-PSSTGAAASPATAATLPVGTGQNASSVGAQLMGASSQPSEAMAPRTGpa 444
Cdd:pfam09770 238 pqiQQQQQPQQQPQQPQQHPGQGHPVTILQrPQSPQPDPAQPSIQPQAQQFHQQPPPVPVQPTQILQNPNRLSAARVG-- 315
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 7662236 445 qggqvAPCQPTGVPPATVGGVVQPCLGPAGAGQPQSVPPPQM 486
Cdd:pfam09770 316 -----YPQNPQPGVQPAPAHQAHRQQGSFGRQAPIITHPQQL 352
|
|
| PRK14951 |
PRK14951 |
DNA polymerase III subunits gamma and tau; Provisional |
431-547 |
6.21e-03 |
|
DNA polymerase III subunits gamma and tau; Provisional
Pssm-ID: 237865 [Multi-domain] Cd Length: 618 Bit Score: 40.08 E-value: 6.21e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236 431 SQPSEAMAPRTGPAQGGQVAPCQPTGVPPATVGGVVQPCLGPAGAGQPQSVPPPQMGGSGPLSAVPGGPHAVVPGvPNVP 510
Cdd:PRK14951 395 AQAAAAPAPAAAPAAAASAPAAPPAAAPPAPVAAPAAAAPAAAPAAAPAAVALAPAPPAQAAPETVAIPVRVAPE-PAVA 473
|
90 100 110
....*....|....*....|....*....|....*..
gi 7662236 511 AAVPAPSVPSVSTTSVTMPNVPAPLAQSQQLSSHTPV 547
Cdd:PRK14951 474 SAAPAPAAAPAAARLTPTEEGDVWHATVQQLAAAEAI 510
|
|
| PRK07003 |
PRK07003 |
DNA polymerase III subunit gamma/tau; |
216-483 |
1.00e-02 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 235906 [Multi-domain] Cd Length: 830 Bit Score: 39.45 E-value: 1.00e-02
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236 216 SGLGATGGSVVVVVASMQGAHGPESGTDSSLTAVSQLPPSeKMSQPTPAQPQSFSVGQPQPPPPPVGGAVAQSSAPLPPF 295
Cdd:PRK07003 363 TGGGAPGGGVPARVAGAVPAPGARAAAAVGASAVPAVTAV-TGAAGAALAPKAAAAAAATRAEAPPAAPAPPATADRGDD 441
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236 296 PGAATGPQPMMAAAQPSQPQGAGPGGQTLPPTNVTLAQPAMSLPPQPGPAVGAPAAQQPQQFAYPQPqiPPGHLLPVQPS 375
Cdd:PRK07003 442 AADGDAPVPAKANARASADSRCDERDAQPPADSGSASAPASDAPPDAAFEPAPRAAAPSAATPAAVP--DARAPAAASRE 519
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7662236 376 GQSEYLQQHVAGLQPPSPAQPSSTGAAASPATAATLPVGTGQNASSVGAQLMGASSQPSEAMAPRTGPAQGGQVAPC-QP 454
Cdd:PRK07003 520 DAPAAAAPPAPEARPPTPAAAAPAARAGGAAAALDVLRNAGMRVSSDRGARAAAAAKPAAAPAAAPKPAAPRVAVQVpTP 599
|
250 260
....*....|....*....|....*....
gi 7662236 455 TGVPPATVGGVVQPCLGPAGAGQPQSVPP 483
Cdd:PRK07003 600 RARAATGDAPPNGAARAEQAAESRGAPPP 628
|
|
| |
