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Conserved domains on  [gi|217330656|ref|NP_055588|]
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death ligand signal enhancer precursor [Homo sapiens]

Protein Classification

tetratricopeptide repeat protein( domain architecture ID 11434433)

tetratricopeptide repeat (TPR) protein may adopt a right-handed helical structure with an amphipathic channel and may function as an interaction scaffold in the formation of multi-protein complexes

CATH:  1.25.40.10
Gene Ontology:  GO:0005515
PubMed:  10517866|30708253
SCOP:  3001345

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TPR COG0790
TPR repeat [General function prediction only];
259-438 1.01e-39

TPR repeat [General function prediction only];


:

Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 144.30  E-value: 1.01e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217330656 259 GDHTAAFSYFQKAAARGYSKAQYNAGLCHEHGRGTPRDISKAVLYYQLAASQGHSLAQYRYARCLL------RDPAsswn 332
Cdd:COG0790   45 AGAAAAAAAAAAAAAAGGAEAQYNLGLMYAEGRGVPKDYEKALEWFEKAAEQGDAEAQYNLGLMYEeglgvpQDYA---- 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217330656 333 perqRAVSLLKQAADSGLREAQAFLGVLFTKEPYL--DEQRAVKYLWLAANNGDSQSRYHLGICYEKGLGVQRNLGEALR 410
Cdd:COG0790  121 ----KALEWYEKAAEQGDADAQYNLGLLYLNGEGVpkDPAKAAEWYRKAAEQGDADAQYNLGVLYENGRGVPKDPAKALE 196

                        170       180
                 ....*....|....*....|....*...
gi 217330656 411 CYQQSAALGNEAAQERLRALFSMGAAAP 438
Cdd:COG0790  197 WYRKAAEQGDADAQYNLGRLYLNGEGVE 224
 
Name Accession Description Interval E-value
TPR COG0790
TPR repeat [General function prediction only];
259-438 1.01e-39

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 144.30  E-value: 1.01e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217330656 259 GDHTAAFSYFQKAAARGYSKAQYNAGLCHEHGRGTPRDISKAVLYYQLAASQGHSLAQYRYARCLL------RDPAsswn 332
Cdd:COG0790   45 AGAAAAAAAAAAAAAAGGAEAQYNLGLMYAEGRGVPKDYEKALEWFEKAAEQGDAEAQYNLGLMYEeglgvpQDYA---- 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217330656 333 perqRAVSLLKQAADSGLREAQAFLGVLFTKEPYL--DEQRAVKYLWLAANNGDSQSRYHLGICYEKGLGVQRNLGEALR 410
Cdd:COG0790  121 ----KALEWYEKAAEQGDADAQYNLGLLYLNGEGVpkDPAKAAEWYRKAAEQGDADAQYNLGVLYENGRGVPKDPAKALE 196

                        170       180
                 ....*....|....*....|....*...
gi 217330656 411 CYQQSAALGNEAAQERLRALFSMGAAAP 438
Cdd:COG0790  197 WYRKAAEQGDADAQYNLGRLYLNGEGVE 224
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 277-312 4.03e-10

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 54.87  E-value: 4.03e-10
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 217330656   277 SKAQYNAGLCHEHGRGTPRDISKAVLYYQLAASQGH 312
Cdd:smart00671   1 AEAQYNLGQMYEYGLGVPKDLEKALEYYKKAAELGN 36
Sel1 pfam08238
Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.
 277-311 4.33e-09

Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.


Pssm-ID: 429881 [Multi-domain]  Cd Length: 35  Bit Score: 51.75  E-value: 4.33e-09
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 217330656  277 SKAQYNAGLCHEHGRGTPRDISKAVLYYQLAASQG 311
Cdd:pfam08238   1 AEAQYRLGYLYLYGLGVPKDPEKALEWYEKAAELG 35
 
Name Accession Description Interval E-value
TPR COG0790
TPR repeat [General function prediction only];
259-438 1.01e-39

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 144.30  E-value: 1.01e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217330656 259 GDHTAAFSYFQKAAARGYSKAQYNAGLCHEHGRGTPRDISKAVLYYQLAASQGHSLAQYRYARCLL------RDPAsswn 332
Cdd:COG0790   45 AGAAAAAAAAAAAAAAGGAEAQYNLGLMYAEGRGVPKDYEKALEWFEKAAEQGDAEAQYNLGLMYEeglgvpQDYA---- 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217330656 333 perqRAVSLLKQAADSGLREAQAFLGVLFTKEPYL--DEQRAVKYLWLAANNGDSQSRYHLGICYEKGLGVQRNLGEALR 410
Cdd:COG0790  121 ----KALEWYEKAAEQGDADAQYNLGLLYLNGEGVpkDPAKAAEWYRKAAEQGDADAQYNLGVLYENGRGVPKDPAKALE 196

                        170       180
                 ....*....|....*....|....*...
gi 217330656 411 CYQQSAALGNEAAQERLRALFSMGAAAP 438
Cdd:COG0790  197 WYRKAAEQGDADAQYNLGRLYLNGEGVE 224
TPR COG0790
TPR repeat [General function prediction only];
260-418 2.92e-39

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 142.76  E-value: 2.92e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217330656 260 DHTAAFSYFQKAAARGYSKAQYNAGLCHEHGRGTPRDISKAVLYYQLAASQGHSLAQYRYARCLLRDPASSWNPErqRAV 339
Cdd:COG0790   82 DYEKALEWFEKAAEQGDAEAQYNLGLMYEEGLGVPQDYAKALEWYEKAAEQGDADAQYNLGLLYLNGEGVPKDPA--KAA 159

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217330656 340 SLLKQAADSGLREAQAFLGVLftkepYL-------DEQRAVKYLWLAANNGDSQSRYHLGICYEKGLGVQRNLGEALRCY 412
Cdd:COG0790  160 EWYRKAAEQGDADAQYNLGVL-----YEngrgvpkDPAKALEWYRKAAEQGDADAQYNLGRLYLNGEGVEKDLEKALRWL 234


                 ....*.
gi 217330656 413 QQSAAL 418
Cdd:COG0790  235 RKAAEQ 240
TPR COG0790
TPR repeat [General function prediction only];
263-434 5.60e-23

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 97.69  E-value: 5.60e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217330656 263 AAFSYFQKAAARGYSKAQYNAGLCHEHGRGTPRDISKAVLYYQLAASQGHSLAQYRYARCLLRDPASSWNPErqRAVSLL 342
Cdd:COG0790   13 AAAAALAAAAAAAGAAAAAAAAAAAAAALAAAAGAAAAAAAAAAAAAAGGAEAQYNLGLMYAEGRGVPKDYE--KALEWF 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217330656 343 KQAADSGLREAQAFLGVLFTKEPYL--DEQRAVKYLWLAANNGDSQSRYHLGICYEKGLGVQRNLGEALRCYQQSAALGN 420
Cdd:COG0790   91 EKAAEQGDAEAQYNLGLMYEEGLGVpqDYAKALEWYEKAAEQGDADAQYNLGLLYLNGEGVPKDPAKAAEWYRKAAEQGD 170

                        170
                 ....*....|....
gi 217330656 421 EAAQERLRALFSMG 434
Cdd:COG0790  171 ADAQYNLGVLYENG 184
TPR COG0790
TPR repeat [General function prediction only];
292-427 7.70e-17

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 79.97  E-value: 7.70e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217330656 292 GTPRDISKAVLYYQLAASQGHSLAQYRYARCLLRDPASSWNPERQRAVSLLKQAADSGLREAQAFLGVLFTKEPYL--DE 369
Cdd:COG0790    4 AAAAAAAAAAAAAALAAAAAAAGAAAAAAAAAAAAAALAAAAGAAAAAAAAAAAAAAGGAEAQYNLGLMYAEGRGVpkDY 83

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 217330656 370 QRAVKYLWLAANNGDSQSRYHLGICYEKGLGVQRNLGEALRCYQQSAALGNEAAQERL 427
Cdd:COG0790   84 EKALEWFEKAAEQGDAEAQYNLGLMYEEGLGVPQDYAKALEWYEKAAEQGDADAQYNL 141
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 277-312 4.03e-10

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 54.87  E-value: 4.03e-10
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 217330656   277 SKAQYNAGLCHEHGRGTPRDISKAVLYYQLAASQGH 312
Cdd:smart00671   1 AEAQYNLGQMYEYGLGVPKDLEKALEYYKKAAELGN 36
Sel1 pfam08238
Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.
 277-311 4.33e-09

Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.


Pssm-ID: 429881 [Multi-domain]  Cd Length: 35  Bit Score: 51.75  E-value: 4.33e-09
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 217330656  277 SKAQYNAGLCHEHGRGTPRDISKAVLYYQLAASQG 311
Cdd:pfam08238   1 AEAQYRLGYLYLYGLGVPKDPEKALEWYEKAAELG 35
SEL1 smart00671
Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.
 385-420 2.42e-07

Sel1-like repeats; These represent a subfamily of TPR (tetratricopeptide repeat) sequences.


Pssm-ID: 214772 [Multi-domain]  Cd Length: 36  Bit Score: 46.78  E-value: 2.42e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 217330656   385 SQSRYHLGICYEKGLGVQRNLGEALRCYQQSAALGN 420
Cdd:smart00671   1 AEAQYNLGQMYEYGLGVPKDLEKALEYYKKAAELGN 36
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
247-437 4.59e-06

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 48.08  E-value: 4.59e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217330656 247 AFNFLGTENMKSGDHTAAFSYFQKAAA--RGYSKAQYNAGLCHEHgRGtprDISKAVLYYQ--LAASQGHSLAQYRYARC 322
Cdd:COG0457   10 AYNNLGLAYRRLGRYEEAIEDYEKALEldPDDAEALYNLGLAYLR-LG---RYEEALADYEqaLELDPDDAEALNNLGLA 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217330656 323 LLRDpasswnPERQRAVSLLKQA--ADSGLREAQAFLGVLFTKEpyLDEQRAVKYL--WLAANNGDSQSRYHLGICYEKg 398
Cdd:COG0457   86 LQAL------GRYEEALEDYDKAleLDPDDAEALYNLGLALLEL--GRYDEAIEAYerALELDPDDADALYNLGIALEK- 156

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 217330656 399 lgvQRNLGEALRCYQQSAALGNEAAQERLRALFSMGAAA 437
Cdd:COG0457  157 ---LGRYEEALELLEKLEAAALAALLAAALGEAALALAA 192
Sel1 pfam08238
Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.
 385-419 5.91e-06

Sel1 repeat; This short repeat is found in the Sel1 protein. It is related to TPR repeats.


Pssm-ID: 429881 [Multi-domain]  Cd Length: 35  Bit Score: 42.89  E-value: 5.91e-06
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 217330656  385 SQSRYHLGICYEKGLGVQRNLGEALRCYQQSAALG 419
Cdd:pfam08238   1 AEAQYRLGYLYLYGLGVPKDPEKALEWYEKAAELG 35
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 229-437 3.03e-04

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 42.79  E-value: 3.03e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217330656 229 LEEAVTSIQQLFQL---SVSIAFNfLGTENMKSGDHTAAFSYFQKAAARGYSKAQYNAGLCHEHGRGtpRDISKAVLYYQ 305
Cdd:COG2956   24 PDKAIDLLEEALELdpeTVEAHLA-LGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKA--GLLDRAEELLE 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 217330656 306 --LAASQGHSLAQYRYARCLLRdpASSWnperQRAVSLLKQAADSGLREAQAF--LGVLFTKEPYLDEqrAVKYLW--LA 379
Cdd:COG2956  101 klLELDPDDAEALRLLAEIYEQ--EGDW----EKAIEVLERLLKLGPENAHAYceLAELYLEQGDYDE--AIEALEkaLK 172

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 217330656 380 ANNGDSQSRYHLGICYEKglgvQRNLGEALRCYQQSAalgnEAAQERLRALFSMGAAA 437
Cdd:COG2956  173 LDPDCARALLLLAELYLE----QGDYEEAIAALERAL----EQDPDYLPALPRLAELY 222
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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