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Conserved domains on  [gi|612407827|ref|NP_055186|]
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A-kinase anchor protein 8-like isoform 1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AKAP95 pfam04988
A-kinase anchoring protein 95 (AKAP95); A-kinase (or PKA)-anchoring protein AKAP95 is ...
 414-549 4.04e-72

A-kinase anchoring protein 95 (AKAP95); A-kinase (or PKA)-anchoring protein AKAP95 is implicated in mitotic chromosome condensation by acting as a targeting molecule for the condensin complex. The protein contains two zinc fingers which are thought to mediate the binding of AKAP95 to DNA.


:

Pssm-ID: 461509  Cd Length: 136  Bit Score: 228.90  E-value: 4.04e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612407827  414 KEHFKYV--GTKLPKQTADFLQEYVTNKTKKTEELRKTVEDLDGLIQQiyRDQDLTQEIAMEHFVKKVEAAHCAACDLFI 491
Cdd:pfam04988   1 KETLDYIqkQTKFDKVVMEFLHECMVNKFKKTEERRQQLNDLESVKKQ--IEKDVMEGVTEEDFMKKVEAAHCAACDLLI 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 612407827  492 PMQFGIIQKHLKTMDHNRNRRLMMEQSKKSSLMVARSILNNKLISKKLERYLKGENPF 549
Cdd:pfam04988  79 PAQFSSVQQHLKSADHNKNKRLYKEQSKKESLLTATSILNNPHIKARYEKYIKGENPF 136
RNA_pol_3_Rpc31 pfam11705
DNA-directed RNA polymerase III subunit Rpc31; RNA polymerase III contains seventeen subunits ...
 263-348 6.58e-03

DNA-directed RNA polymerase III subunit Rpc31; RNA polymerase III contains seventeen subunits in yeasts and in human cells. Twelve of these are akin to RNA polymerase I or II and the other five are RNA pol III-specific, and form the functionally distinct groups (i) Rpc31-Rpc34-Rpc82, and (ii) Rpc37-Rpc53. Rpc31, Rpc34 and Rpc82 form a cluster of enzyme-specific subunits that contribute to transcription initiation in S.cerevisiae and H.sapiens. There is evidence that these subunits are anchored at or near the N-terminal Zn-fold of Rpc1, itself prolonged by a highly conserved but RNA polymerase III-specific domain.


:

Pssm-ID: 463324  Cd Length: 213  Bit Score: 38.51  E-value: 6.58e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612407827  263 WKTWTTADF-RTKKKKRKQGGSPdePDSKATRTDCSDNSDSDNDEGTEgeateglegTEAVEKGSRVDGEDEEGKEDGRE 341
Cdd:pfam11705 112 WPTLDGDDVgIAKKKKKKLGLSK--VKSLRNAEDEGEEEEEEEAKGLS---------LLEKLKDLAEDEDDEDEKEEEDE 180


                  ....*..
gi 612407827  342 EGKEDPE 348
Cdd:pfam11705 181 EGEEEIE 187
 
Name Accession Description Interval E-value
AKAP95 pfam04988
A-kinase anchoring protein 95 (AKAP95); A-kinase (or PKA)-anchoring protein AKAP95 is ...
 414-549 4.04e-72

A-kinase anchoring protein 95 (AKAP95); A-kinase (or PKA)-anchoring protein AKAP95 is implicated in mitotic chromosome condensation by acting as a targeting molecule for the condensin complex. The protein contains two zinc fingers which are thought to mediate the binding of AKAP95 to DNA.


Pssm-ID: 461509  Cd Length: 136  Bit Score: 228.90  E-value: 4.04e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612407827  414 KEHFKYV--GTKLPKQTADFLQEYVTNKTKKTEELRKTVEDLDGLIQQiyRDQDLTQEIAMEHFVKKVEAAHCAACDLFI 491
Cdd:pfam04988   1 KETLDYIqkQTKFDKVVMEFLHECMVNKFKKTEERRQQLNDLESVKKQ--IEKDVMEGVTEEDFMKKVEAAHCAACDLLI 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 612407827  492 PMQFGIIQKHLKTMDHNRNRRLMMEQSKKSSLMVARSILNNKLISKKLERYLKGENPF 549
Cdd:pfam04988  79 PAQFSSVQQHLKSADHNKNKRLYKEQSKKESLLTATSILNNPHIKARYEKYIKGENPF 136
RNA_pol_3_Rpc31 pfam11705
DNA-directed RNA polymerase III subunit Rpc31; RNA polymerase III contains seventeen subunits ...
 263-348 6.58e-03

DNA-directed RNA polymerase III subunit Rpc31; RNA polymerase III contains seventeen subunits in yeasts and in human cells. Twelve of these are akin to RNA polymerase I or II and the other five are RNA pol III-specific, and form the functionally distinct groups (i) Rpc31-Rpc34-Rpc82, and (ii) Rpc37-Rpc53. Rpc31, Rpc34 and Rpc82 form a cluster of enzyme-specific subunits that contribute to transcription initiation in S.cerevisiae and H.sapiens. There is evidence that these subunits are anchored at or near the N-terminal Zn-fold of Rpc1, itself prolonged by a highly conserved but RNA polymerase III-specific domain.


Pssm-ID: 463324  Cd Length: 213  Bit Score: 38.51  E-value: 6.58e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612407827  263 WKTWTTADF-RTKKKKRKQGGSPdePDSKATRTDCSDNSDSDNDEGTEgeateglegTEAVEKGSRVDGEDEEGKEDGRE 341
Cdd:pfam11705 112 WPTLDGDDVgIAKKKKKKLGLSK--VKSLRNAEDEGEEEEEEEAKGLS---------LLEKLKDLAEDEDDEDEKEEEDE 180


                  ....*..
gi 612407827  342 EGKEDPE 348
Cdd:pfam11705 181 EGEEEIE 187
 
Name Accession Description Interval E-value
AKAP95 pfam04988
A-kinase anchoring protein 95 (AKAP95); A-kinase (or PKA)-anchoring protein AKAP95 is ...
 414-549 4.04e-72

A-kinase anchoring protein 95 (AKAP95); A-kinase (or PKA)-anchoring protein AKAP95 is implicated in mitotic chromosome condensation by acting as a targeting molecule for the condensin complex. The protein contains two zinc fingers which are thought to mediate the binding of AKAP95 to DNA.


Pssm-ID: 461509  Cd Length: 136  Bit Score: 228.90  E-value: 4.04e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612407827  414 KEHFKYV--GTKLPKQTADFLQEYVTNKTKKTEELRKTVEDLDGLIQQiyRDQDLTQEIAMEHFVKKVEAAHCAACDLFI 491
Cdd:pfam04988   1 KETLDYIqkQTKFDKVVMEFLHECMVNKFKKTEERRQQLNDLESVKKQ--IEKDVMEGVTEEDFMKKVEAAHCAACDLLI 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 612407827  492 PMQFGIIQKHLKTMDHNRNRRLMMEQSKKSSLMVARSILNNKLISKKLERYLKGENPF 549
Cdd:pfam04988  79 PAQFSSVQQHLKSADHNKNKRLYKEQSKKESLLTATSILNNPHIKARYEKYIKGENPF 136
RNA_pol_3_Rpc31 pfam11705
DNA-directed RNA polymerase III subunit Rpc31; RNA polymerase III contains seventeen subunits ...
 263-348 6.58e-03

DNA-directed RNA polymerase III subunit Rpc31; RNA polymerase III contains seventeen subunits in yeasts and in human cells. Twelve of these are akin to RNA polymerase I or II and the other five are RNA pol III-specific, and form the functionally distinct groups (i) Rpc31-Rpc34-Rpc82, and (ii) Rpc37-Rpc53. Rpc31, Rpc34 and Rpc82 form a cluster of enzyme-specific subunits that contribute to transcription initiation in S.cerevisiae and H.sapiens. There is evidence that these subunits are anchored at or near the N-terminal Zn-fold of Rpc1, itself prolonged by a highly conserved but RNA polymerase III-specific domain.


Pssm-ID: 463324  Cd Length: 213  Bit Score: 38.51  E-value: 6.58e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612407827  263 WKTWTTADF-RTKKKKRKQGGSPdePDSKATRTDCSDNSDSDNDEGTEgeateglegTEAVEKGSRVDGEDEEGKEDGRE 341
Cdd:pfam11705 112 WPTLDGDDVgIAKKKKKKLGLSK--VKSLRNAEDEGEEEEEEEAKGLS---------LLEKLKDLAEDEDDEDEKEEEDE 180


                  ....*..
gi 612407827  342 EGKEDPE 348
Cdd:pfam11705 181 EGEEEIE 187
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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