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Conserved domains on  [gi|21265040|ref|NP_054899|]
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large ribosomal subunit protein uL22m isoform a [Homo sapiens]

Protein Classification

uL22 family ribosomal protein( domain architecture ID 10446401)

uL22 family ribosomal protein binds specifically to rRNA and is important during the early stages of ribosome assembly.

Gene Ontology:  GO:0042255|GO:0003735
PubMed:  24524803

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ribosomal_L22 pfam00237
Ribosomal protein L22p/L17e; This family includes L22 from prokaryotes and chloroplasts and ...
 69-172 1.01e-35

Ribosomal protein L22p/L17e; This family includes L22 from prokaryotes and chloroplasts and L17 from eukaryotes.


:

Pssm-ID: 459725  Cd Length: 104  Bit Score: 121.35  E-value: 1.01e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21265040    69 HCRRQIKYSKDKMWYLAKLIRGMSIDQALAQLEFNDKKGAKIIKEVLLEAQDMAVRDHNVEfRSNLYIAESTSGRGQCLK 148
Cdd:pfam00237   1 AKARNLRISPKKARLVADLIRGMSVDEALAILKFSPKKAAKIVLKLLKSAIANAENKGNLD-VDNLYISEIQVDKGPTLK 79

                          90       100
                  ....*....|....*....|....
gi 21265040   149 RIRYHGRGRFGIMEKVYCHYFVKL 172
Cdd:pfam00237  80 RIRPRARGRAGPIRKRTSHITVVL 103
 
Name Accession Description Interval E-value
Ribosomal_L22 pfam00237
Ribosomal protein L22p/L17e; This family includes L22 from prokaryotes and chloroplasts and ...
 69-172 1.01e-35

Ribosomal protein L22p/L17e; This family includes L22 from prokaryotes and chloroplasts and L17 from eukaryotes.


Pssm-ID: 459725  Cd Length: 104  Bit Score: 121.35  E-value: 1.01e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21265040    69 HCRRQIKYSKDKMWYLAKLIRGMSIDQALAQLEFNDKKGAKIIKEVLLEAQDMAVRDHNVEfRSNLYIAESTSGRGQCLK 148
Cdd:pfam00237   1 AKARNLRISPKKARLVADLIRGMSVDEALAILKFSPKKAAKIVLKLLKSAIANAENKGNLD-VDNLYISEIQVDKGPTLK 79

                          90       100
                  ....*....|....*....|....
gi 21265040   149 RIRYHGRGRFGIMEKVYCHYFVKL 172
Cdd:pfam00237  80 RIRPRARGRAGPIRKRTSHITVVL 103
Ribosomal_L22 cd00336
Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal ...
 67-172 2.17e-32

Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper folding and stabilizing the conformation of 23S rRNA. L22 is the largest protein contributor to the surface of the polypeptide exit channel, the tunnel through which the polypeptide product passes. L22 is also one of six proteins located at the putative translocon binding site on the exterior surface of the ribosome.


Pssm-ID: 238205  Cd Length: 105  Bit Score: 112.58  E-value: 2.17e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21265040  67 IYHCRRQIKYSKDKMWYLAKLIRGMSIDQALAQLEFNDKKGAKIIKEVLLEAQDMAVRDHNVEfRSNLYIAESTSGRGQC 146
Cdd:cd00336   1 AKAKGRYLRISPKKARLVARLIRGMSVDEALAQLEFVPKKAAKIILKLLKSAEANAENNGLDD-PDKLYIKHIQVNKGPT 79

                        90       100
                ....*....|....*....|....*.
gi 21265040 147 LKRIRYHGRGRFGIMEKVYCHYFVKL 172
Cdd:cd00336  80 LKRRRPRARGRANPIRKRTCHITVVL 105
RplV COG0091
Ribosomal protein L22 [Translation, ribosomal structure and biogenesis]; Ribosomal protein L22 ...
 72-174 8.89e-18

Ribosomal protein L22 [Translation, ribosomal structure and biogenesis]; Ribosomal protein L22 is part of the Pathway/BioSystem: Ribosome 50S subunit


Pssm-ID: 439861  Cd Length: 110  Bit Score: 75.08  E-value: 8.89e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21265040  72 RQIKYSKDKMWYLAKLIRGMSIDQALAQLEFNDKKGAKIIKEVLLEAQDMAVRDHNVEfRSNLYIAESTSGRGQCLKRIR 151
Cdd:COG0091   8 RYVRISPRKARLVADLIRGKKVEEALAILEFSPKKAARIVLKVLKSAIANAENNNGLD-VDNLVVKEIFVDKGPTLKRFR 86

                        90       100
                ....*....|....*....|...
gi 21265040 152 YHGRGRFGIMEKVYCHYFVKLVE 174
Cdd:COG0091  87 PRARGRATRIRKRTSHITVVVSE 109
rpl22 CHL00034
ribosomal protein L22
 66-167 5.89e-06

ribosomal protein L22


Pssm-ID: 214342  Cd Length: 117  Bit Score: 43.77  E-value: 5.89e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21265040   66 EIYHCRRQIKYSKDKMWYLAKLIRGMSIDQALAQLEFNDKKGAKIIKEVLLEAQDMAvrDHNVEF-RSNLYIAESTSGRG 144
Cdd:CHL00034   9 EVYALAKYIRMSAHKARRVIDQIRGRSYEEALMILEFMPYRACYPILKLVYSAAANA--SHNMGLnKANLFISKAEVDEG 86

                         90       100
                 ....*....|....*....|...
gi 21265040  145 QCLKRIRYHGRGRFGIMEKVYCH 167
Cdd:CHL00034  87 PTLKRFRPRAQGRSYPIKKPTCH 109
 
Name Accession Description Interval E-value
Ribosomal_L22 pfam00237
Ribosomal protein L22p/L17e; This family includes L22 from prokaryotes and chloroplasts and ...
 69-172 1.01e-35

Ribosomal protein L22p/L17e; This family includes L22 from prokaryotes and chloroplasts and L17 from eukaryotes.


Pssm-ID: 459725  Cd Length: 104  Bit Score: 121.35  E-value: 1.01e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21265040    69 HCRRQIKYSKDKMWYLAKLIRGMSIDQALAQLEFNDKKGAKIIKEVLLEAQDMAVRDHNVEfRSNLYIAESTSGRGQCLK 148
Cdd:pfam00237   1 AKARNLRISPKKARLVADLIRGMSVDEALAILKFSPKKAAKIVLKLLKSAIANAENKGNLD-VDNLYISEIQVDKGPTLK 79

                          90       100
                  ....*....|....*....|....
gi 21265040   149 RIRYHGRGRFGIMEKVYCHYFVKL 172
Cdd:pfam00237  80 RIRPRARGRAGPIRKRTSHITVVL 103
Ribosomal_L22 cd00336
Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal ...
 67-172 2.17e-32

Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper folding and stabilizing the conformation of 23S rRNA. L22 is the largest protein contributor to the surface of the polypeptide exit channel, the tunnel through which the polypeptide product passes. L22 is also one of six proteins located at the putative translocon binding site on the exterior surface of the ribosome.


Pssm-ID: 238205  Cd Length: 105  Bit Score: 112.58  E-value: 2.17e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21265040  67 IYHCRRQIKYSKDKMWYLAKLIRGMSIDQALAQLEFNDKKGAKIIKEVLLEAQDMAVRDHNVEfRSNLYIAESTSGRGQC 146
Cdd:cd00336   1 AKAKGRYLRISPKKARLVARLIRGMSVDEALAQLEFVPKKAAKIILKLLKSAEANAENNGLDD-PDKLYIKHIQVNKGPT 79

                        90       100
                ....*....|....*....|....*.
gi 21265040 147 LKRIRYHGRGRFGIMEKVYCHYFVKL 172
Cdd:cd00336  80 LKRRRPRARGRANPIRKRTCHITVVL 105
RplV COG0091
Ribosomal protein L22 [Translation, ribosomal structure and biogenesis]; Ribosomal protein L22 ...
 72-174 8.89e-18

Ribosomal protein L22 [Translation, ribosomal structure and biogenesis]; Ribosomal protein L22 is part of the Pathway/BioSystem: Ribosome 50S subunit


Pssm-ID: 439861  Cd Length: 110  Bit Score: 75.08  E-value: 8.89e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21265040  72 RQIKYSKDKMWYLAKLIRGMSIDQALAQLEFNDKKGAKIIKEVLLEAQDMAVRDHNVEfRSNLYIAESTSGRGQCLKRIR 151
Cdd:COG0091   8 RYVRISPRKARLVADLIRGKKVEEALAILEFSPKKAARIVLKVLKSAIANAENNNGLD-VDNLVVKEIFVDKGPTLKRFR 86

                        90       100
                ....*....|....*....|...
gi 21265040 152 YHGRGRFGIMEKVYCHYFVKLVE 174
Cdd:COG0091  87 PRARGRATRIRKRTSHITVVVSE 109
rpl22 CHL00034
ribosomal protein L22
 66-167 5.89e-06

ribosomal protein L22


Pssm-ID: 214342  Cd Length: 117  Bit Score: 43.77  E-value: 5.89e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21265040   66 EIYHCRRQIKYSKDKMWYLAKLIRGMSIDQALAQLEFNDKKGAKIIKEVLLEAQDMAvrDHNVEF-RSNLYIAESTSGRG 144
Cdd:CHL00034   9 EVYALAKYIRMSAHKARRVIDQIRGRSYEEALMILEFMPYRACYPILKLVYSAAANA--SHNMGLnKANLFISKAEVDEG 86

                         90       100
                 ....*....|....*....|...
gi 21265040  145 QCLKRIRYHGRGRFGIMEKVYCH 167
Cdd:CHL00034  87 PTLKRFRPRAQGRSYPIKKPTCH 109
PRK12279 PRK12279
50S ribosomal protein L22/unknown domain fusion protein; Provisional
 71-167 1.40e-03

50S ribosomal protein L22/unknown domain fusion protein; Provisional


Pssm-ID: 138835 [Multi-domain]  Cd Length: 311  Bit Score: 38.52  E-value: 1.40e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21265040   71 RRQIKYSKDKMWYLAKLIRGMSIDQALAQLEFNDKKGAKIIKEVLLEAQDMAVRDHNVEFRSNLYIAESTSGRGQCLKRI 150
Cdd:PRK12279   7 QRNIHISHRKASLVIDLVRNKPVHEAIRILSNTPKKFAPIVLKLLNSAISNVQHNSKDMDPSKLYIYKIVANQGPTMKRT 86

                         90
                 ....*....|....*..
gi 21265040  151 RYHGRGRFGIMEKVYCH 167
Cdd:PRK12279  87 LPRAKGSADQLFKRTTH 103
Tudor_TDRD8 cd20430
Tudor domain found in Tudor domain-containing protein 8 (TDRD8) and similar proteins; TDRD8, ...
 55-99 8.07e-03

Tudor domain found in Tudor domain-containing protein 8 (TDRD8) and similar proteins; TDRD8, also called serine/threonine-protein kinase (EC 2.7.11.1) 31 (STK31), serine/threonine-protein kinase NYD-SPK, or Sugen kinase 396 (SgK396), is a germ cell-specific factor expressed in embryonic gonocytes of both sexes, and in postnatal spermatocytes and round spermatids in males. It acts as a cell-cycle regulated protein that contributes to the tumorigenicity of epithelial cancer cells. TDRD8 contains a Tudor domain and a serine/threonine kinase domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410501 [Multi-domain]  Cd Length: 75  Bit Score: 34.19  E-value: 8.07e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 21265040  55 PQLPGEPRrPAEIYHCrrqiKYSKDKMWYLAKLIRGMSIDQALAQ 99
Cdd:cd20430  13 PPLFGTPD-PNKIYGG----KFSEDNCWYRCKVKSILSDEKCTVQ 52
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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