|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_FLVCR1 |
cd17455 |
Feline leukemia virus subgroup C receptor-related protein 1 of the Major Facilitator ... |
106-512 |
0e+00 |
|
Feline leukemia virus subgroup C receptor-related protein 1 of the Major Facilitator Superfamily of transporters; Feline leukemia virus subgroup C receptor-related protein 1 (FLVCR1) is also called feline leukemia virus subgroup C receptor (FLVCR). FLVCR1 is a heme transporter and it has two isoforms: 1 (or FLVCR1a), which exports cytoplasmic heme as well as coproporphyrin and protoporphyrin IX; and 2 (FLVCR1b), which promotes heme efflux from the mitochondrion to the cytoplasm. Mutations in the FLVCR1 gene have been linked to vision impairment, posterior column ataxia, and sensory neurodegeneration with loss of pain perception. FLVCR1 belongs to the Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341013 Cd Length: 407 Bit Score: 767.07 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7661708 106 RRFVVLLIFSLYSLVNAFQWIQYSIISNVFEGFYGVTLLHIDWLSMVYMLAYVPLIFPATWLLDTRGLRLTALLGSGLNC 185
Cdd:cd17455 1 RRFAVLAVFSLYSLVNAFQWIQYSIITNIFTEFYGVSSGAIDWLSVVYMVAYVPLIFPATWLLDLKGLRVTALLGAGLNC 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7661708 186 LGAWIKCGSVQQHLFWVTMLGQCLCSVAQVFILGLPSRIASVWFGPKEVSTACATAVLGNQLGTAVGFLLPPVLVPNTQN 265
Cdd:cd17455 81 LGAWVKCASVRPDLFGVTMLAQVLCSVAQVFILGLPSRIASVWFGPREVSTACAVAVLGNQLGTAIGFLLPPVLVPNTVD 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7661708 266 DTNLLACNISTMFYGTSAVATLLFILTAIAFKEKPRYPPSQAQAALQDSPPEEYSYKKSIRNLFKNIPFVLLLITYGIMT 345
Cdd:cd17455 161 DIDLMGHNISIMFYGTAAVSTLLFILTIIVFKEKPPLPPSQAQAVLQGIPSEDYSYKQSIINLFKNVPFVLLLISYGIMT 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7661708 346 GAFYSVSTLLNQMILTYYEGEEVNAGRIGLTLVVAGMVGSILCGLWLDYTKTYKQTTLIVYILSFIGMVIFTFTLDLRYI 425
Cdd:cd17455 241 GTFYSVSTLLNQMIITHYEGEEVNAGRIGLTLVVAGMVGSILCGLWLDYTKTYKQTTLIVYILSFIGMVVFTFTLDLGYL 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7661708 426 IIVFVTGGVLGFFMTGYLPLGFEFAVEITYPESEGTSSGLLNASAQIFGILFTLAQGKLTSDYGPKAGNIFLCVWMFIGI 505
Cdd:cd17455 321 IVVFVTGGVLGFFMTGYLPLGFEFAVEITYPESEGTSSGLLNASAQIFGIIFTLIQGKLTTDYGPQAGNIFLCAWIFVGI 400
|
....*..
gi 7661708 506 ILTALIK 512
Cdd:cd17455 401 ILTALIK 407
|
|
| MFS_FLVCR_like |
cd17398 |
Feline leukemia virus subgroup C receptor subfamily of the Major Facilitator Superfamily of ... |
106-512 |
0e+00 |
|
Feline leukemia virus subgroup C receptor subfamily of the Major Facilitator Superfamily of transporters; The Feline leukemia virus subgroup C receptor (FLVCR) subfamily is conserved in metazoans and is composed of two vertebrate members, FLVCR1 and FLVCR2. FLVCR1 is a heme transporter and it has two isoforms: 1 (or FLVCR1a), which exports cytoplasmic heme as well as coproporphyrin and protoporphyrin IX; and 2 (FLVCR1b), which promotes heme efflux from the mitochondrion to the cytoplasm. FLVCR2 functions as a heme importer as well as a transporter for a calcium-chelator complex that is important for growth and calcium metabolism. The FLVCR subfamily belongs to the Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340956 [Multi-domain] Cd Length: 406 Bit Score: 662.40 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7661708 106 RRFVVLLIFSLYSLVNAFQWIQYSIISNVFEGFYGVTLLHIDWLSMVYMLAYVPLIFPATWLLDTRGLRLTALLGSGLNC 185
Cdd:cd17398 1 RRWIMLFLFCLYSMSNAFQWIQYAIISNIIVDYYGVSDTAVDWTSMIYMLTYIPLIFPATWLLEKYGLRVTVLLGSFLNC 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7661708 186 LGAWIKCGSVQQHLFWVTMLGQCLCSVAQVFILGLPSRIASVWFGPKEVSTACATAVLGNQLGTAVGFLLPPVLVPNTQN 265
Cdd:cd17398 81 LGAWLKLFSSSPDLFWVAMAGQTICALAQVFILGIPPRLAAVWFGPDEVSTATAIGVFGNQLGVALGFVLPPLLVPNSEN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7661708 266 DTnLLACNISTMFYGTSAVATLLFILTAIAFKEKPRYPPSQAQAALQDSPPEEYSYKKSIRNLFKNIPFVLLLITYGIMT 345
Cdd:cd17398 161 KD-EIGKGLSILFYGVAGICTALFILVIIFFKEKPPIPPSRAQAAAQELRSEDQSYLGSLKRLFKNKGFLLLLITYGINT 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7661708 346 GAFYSVSTLLNQMILTYYEGEEVNAGRIGLTLVVAGMVGSILCGLWLDYTKTYKQTTLIVYILSFIGMVIFTFTLDLRYI 425
Cdd:cd17398 240 GVYYAISTLLNQMVLEYFPNEEVNAGWIGLTLVIAGLVGSVVAGIWLDKTKKYKETTIIVYILSFIGMVAFTFTLDLGSI 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7661708 426 IIVFVTGGVLGFFMTGYLPLGFEFAVEITYPESEGTSSGLLNASAQIFGILFTLAQGKLTSDYGPKAGNIFLCVWMFIGI 505
Cdd:cd17398 320 WVVFLTAGALGFFMTGYLPVGFEFAAELTYPEPEGTSSGLLNASAQIFGIIFTLVMGALLDKVGALASNIVLSVALLLGT 399
|
....*..
gi 7661708 506 ILTALIK 512
Cdd:cd17398 400 ILTAFIK 406
|
|
| MFS_FLVCR2 |
cd17456 |
Feline leukemia virus subgroup C receptor-related protein 2 of the Major Facilitator ... |
106-512 |
0e+00 |
|
Feline leukemia virus subgroup C receptor-related protein 2 of the Major Facilitator Superfamily of transporters; Feline leukemia virus subgroup C receptor-related protein 2 (FLVCR2) is also called calcium-chelate transporter (CCT). It functions as a heme importer as well as a transporter for a calcium-chelator complex that is important for growth and calcium metabolism. Mutations in the FLVCR2 gene cause Proliferative vasculopathy and hydranencephaly-hydrocephaly syndrome (PVHH), also known as Fowler syndrome, a rare autosomal recessive disorder characterized by glomerular vasculopathy in the central nervous system, severe hydrocephaly, hypokinesia and arthrogryphosis. FLVCR2 belongs to the Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341014 Cd Length: 406 Bit Score: 649.15 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7661708 106 RRFVVLLIFSLYSLVNAFQWIQYSIISNVFEGFYGVTLLHIDWLSMVYMLAYVPLIFPATWLLDTRGLRLTALLGSGLNC 185
Cdd:cd17456 1 RRWVIVLLFSSYSLCNAFQWIQYGIINNIFMHFYGVSSFAIDWLSMSYMLTYIPLIFPVAWLLDKRGLRVIALVGSALNC 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7661708 186 LGAWIKCGSVQQHLFWVTMLGQCLCSVAQVFILGLPSRIASVWFGPKEVSTACATAVLGNQLGTAVGFLLPPVLVPNTQn 265
Cdd:cd17456 81 LGAWIKTGSARPDLFPVTVLGQLVCSVAQVFILGMPSRIASVWFGSSEVSTACSIGVFGNQLGVAIGFLLPPVLVPNID- 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7661708 266 DTNLLACNISTMFYGTSAVATLLFILTAIAFKEKPRYPPSQAQAALQDSPPEEYSYKKSIRNLFKNIPFVLLLITYGIMT 345
Cdd:cd17456 160 DLDELAYHISIMFYGTAAVATLLFILVIIVFQEKPKIPPSQAQAAIQSIPSQDYSYLQSILRLLKNVNFILLVVSYGLNT 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7661708 346 GAFYSVSTLLNQMILTYYEGEEVNAGRIGLTLVVAGMVGSILCGLWLDYTKTYKQTTLIVYILSFIGMVIFTFTLDLRYI 425
Cdd:cd17456 240 GCFYALSTLLNRMVIFHYPGEEVNAGRIGLTIVVAGMVGALISGIWLDRTKTYKQTTLAVYIMSLVGMVVYTFTLNLGHL 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7661708 426 IIVFVTGGVLGFFMTGYLPLGFEFAVEITYPESEGTSSGLLNASAQIFGILFTLAQGKLTSDYGPKAGNIFLCVWMFIGI 505
Cdd:cd17456 320 WVVFITAGTLGFFMTGYLPLGFEFAAELTYPESEGTSSGLLNVSAQVFGIIFTISQGQIIDNFGTKAGNIFLCAFLLVGT 399
|
....*..
gi 7661708 506 ILTALIK 512
Cdd:cd17456 400 ILTALIK 406
|
|
| MFS_SLC49 |
cd17334 |
Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily of transporters; The ... |
106-512 |
1.85e-172 |
|
Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily of transporters; The Solute carrier 49 (SLC49) family is composed of four members: feline leukemia virus subgroup C receptor 1 (FLVCR1, SLC49A1); FLVCR2 (SLC49A2); major facilitator superfamily domain-containing protein 7 (MFSD7, SLC49A3); and disrupted in renal carcinoma protein 2 (DIRC2, SLC49A4). FLVCR1 and FLVCR2 are heme transporters. In addition, FLVCR2 also functions as a transporter for a calcium-chelator complex that is important for growth and calcium metabolism. The function of MFSD7 is unknown. DIRC2 is an electrogenic lysosomal metabolite transporter that is regulated by limited proteolytic processing by cathepsin L. The SLC49 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340892 [Multi-domain] Cd Length: 407 Bit Score: 493.84 E-value: 1.85e-172
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7661708 106 RRFVVLLIFSLYSLVNAFQWIQYSIISNVFEGFYGVTLLHIDWLSMVYMLAYVPLIFPATWLLDTRGLRLTALLGSGLNC 185
Cdd:cd17334 1 RRWVVLLLFSLLSFSNAMQWITFSPIADEARTFFDLSASQINWLSLVYPIVYVPGVFAFCWLLDKVGLRIGVLIGAALNA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7661708 186 LGAWIKCGS-VQQHLFWVTMLGQCLCSVAQVFILGLPSRIASVWFGPKEVSTACATAVLGNQLGTAVGFLLPPVLVPNTQ 264
Cdd:cd17334 81 LGSVLKCIPlGQQPKFALLVLGQVLNALAQVLVLSLPPLIAAVWFPPKERTTATAIASLANFLGCAIGFLLPPVVVPPPK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7661708 265 NDTnllaCNISTMFYGTSAVATLLFILTAIAFKEKPRYPPSQAQAALQDSPPEEYSYKKSIRNLFKNIPFVLLLITYGIM 344
Cdd:cd17334 161 GTK----KEFGAVFYGEFGFACLLLALVLALFPPKPKYPPSAASARQQNSEHVILELQKSISELLRNEPFVLLAVAFSIM 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7661708 345 TGAFYSVSTLLNQMILTyYEGEEVNAGRIGLTLVVAGMVGSILCGLWLDYTktyKQTTLIVYILSFIGMVIFTFTLDLR- 423
Cdd:cd17334 237 MGVFAGFSSVLAQILLP-FGVSQTSAGWLGFFGIVAGMVGGLLLGLFVDRT---RMFKLIGLIILALGTVVCTFFMLLVd 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7661708 424 ------YIIIVFVTGGVLGFFMTGYLPLGFEFAVEITYPESEGTSSGLLNASAQIFGILFTLAQGKLTSDYGPKAGNIFL 497
Cdd:cd17334 313 ryglpyVTLAFYLLCGLLGFFQNSMVPIMFELAVELTYPVPESVSTGVLTALANLFSFLLMLVFSELLGPTPTESKYLLW 392
|
410
....*....|....*
gi 7661708 498 CVWMFIGIILTALIK 512
Cdd:cd17334 393 FILCTVGSCLGALFF 407
|
|
| MFS_MFSD7 |
cd17399 |
Major facilitator superfamily domain-containing protein 7; Major facilitator superfamily ... |
106-481 |
1.59e-82 |
|
Major facilitator superfamily domain-containing protein 7; Major facilitator superfamily domain-containing protein 7 (MFSD7) is also called myosin light polypeptide 5 regulatory protein (MYL5). It's function is unknown. It is encoded by the a SLC49A3 gene and is a member of the Solute carrier 49 (SLC49) family, which also includes feline leukemia virus subgroup C receptor 1 (FLVCR1, SLC49A1), FLVCR2 (SLC49A2), as well as disrupted in renal carcinoma protein 2 (DIRC2, SLC49A4). FLVCR1 and FLVCR2 are heme transporters. DIRC2 is an electrogenic lysosomal metabolite transporter that is regulated by limited proteolytic processing by cathepsin L. MFSD7 belongs to the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340957 Cd Length: 419 Bit Score: 263.74 E-value: 1.59e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7661708 106 RRFVVLLIFSLYSLVNAFQWIQYSIISNVFEGFYGVTLLHIDWLSMVYMLAYVPLIFPATWLLDTRGLRLTALLGSGLNC 185
Cdd:cd17399 1 RRWFVLLVVCLLNCSNAMIWISFAPVADYTAEYYNVSLDAVNWLSLIYMIVSIPVGFVAMWLLDTLGLRTAIILGAWLNF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7661708 186 LGAWIKCGSV-----QQHLFWVTMLGQCLCSVAQVFILGLPSRIASVWFGPKEVSTACATAVLGNQLGTAVGFLLPPVLV 260
Cdd:cd17399 81 IGAVIRVISSlpfvdPSFRFPVLMTGQTLAAFAQPFILFLPTKLAALWFPDNQRAIANMLASMSNPLGVLLANLLSPLIV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7661708 261 PNTQndtnllacNISTMFYGTSAVATLLFILTAIAFKEKPRYPPSQAQAALQDSPpeeysYKKSIRNLFKNIPFVLLLIT 340
Cdd:cd17399 161 KSSE--------DIFLLLSIYTIPALIAVVLATFGVRSSVPPTPPSASAAHESEP-----FFVGLKQLFKNKQYLILMLC 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7661708 341 YGIMTGAFYSVSTLLNQMILTYYEGEEVnAGRIGLTLVVAGMVGSILCGLWLDYTKTYKQTTLIVYILSFIGMVIFTFTL 420
Cdd:cd17399 228 FGGGIGLFNALSTLLEQILCPSGYSNNF-AGICGALMIGVGLIGAFVAGLIVDKTKKFIEVTKVCFCLAVIFLVAFLVVS 306
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 7661708 421 DLRYI-IIVFVTGGVLGFFMTGYLPLGFEFAVEITYPESEGTSSGLLNASAQIFGILFTLAQ 481
Cdd:cd17399 307 RFPNQsVLLAVLCGLFGFFGFAIYPVGLELAVECTYPVAEATSTGLIFMSGQIQGIILVFIM 368
|
|
| MFS_DIRC2 |
cd17397 |
Disrupted in renal carcinoma protein 2 of the Major Facilitator Superfamily of transporters; ... |
106-479 |
3.00e-53 |
|
Disrupted in renal carcinoma protein 2 of the Major Facilitator Superfamily of transporters; Disrupted in renal carcinoma protein 2 or disrupted in renal cancer protein 2 (DIRC2), encoded by the SLC49A4 gene, was initially identified as a breakpoint-spanning gene in a chromosomal translocation associated with the development of renal cancer. It is an electrogenic lysosomal metabolite transporter that is regulated by limited proteolytic processing by cathepsin L. DIRC2 belongs to the Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340955 [Multi-domain] Cd Length: 381 Bit Score: 185.58 E-value: 3.00e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7661708 106 RRFVVLLIFSLYSLVNAFQWIQYSIISNVFEGFYGVTLLHIDWLSMVYMLAYVPLIFPATWLLDTRGLRLTALLGSGLNC 185
Cdd:cd17397 1 RRWYILLVFSLLAFTQGAVWNTWGPIADSAKPAFGWSDSDIALLANWGPIGFVPTFFFMAWLMDVKGLRIAVLSSAFLVA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7661708 186 LGAWIKCGSVQQHLF-WVTMLGQCLCSVAQVFILGLPSRIASVWFGPKEVSTACATAVLGNQLGTAVGFLLPPVLVpntq 264
Cdd:cd17397 81 AGTGLRCIPVPNHLAtWLIHIGQFLNGLAGPVAMAAAPFLSATWFPPNQRATATAIASIFNYLGGAASFLIGPLVL---- 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7661708 265 ndtnllacnistmFYGTSAVATLLFILTAIAFKEKPRYPPSQAQAAlqdsppEEYSYKKSIRNLFKNIPFVLLLITYGIM 344
Cdd:cd17397 157 -------------MYLEFGWSALIFLAMLIYFPSKPPTPPSVSAST------QRLSYKSGILSLLKNKRFWLIALAYGIP 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7661708 345 TGAFYSVSTLLNqMILTYYEGEEVNAGRIGLTLVVAGMVGSILCGLWLDY-TKTYKQTTLIVYILSFIGMVIFTFTLdLR 423
Cdd:cd17397 218 TGVYAGWSGVLD-VNLTPFGVSQVEAGWIGFYSTVAGCVGGIIVGRFADRfGGRMKLILLLLFSGATGSFLWFTLIC-LK 295
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 7661708 424 YI----IIVFVTGGVLGFFMTGYLPLGFEFAVEITYPESEGTSSGLLNASAQIFGILFTL 479
Cdd:cd17397 296 LLpfstVSLYTSCILLGVFLNGSVPLFYELAVEAAYPVPEGITSGVLTFLNNVFGLVFLL 355
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
114-508 |
1.67e-37 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 142.57 E-value: 1.67e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7661708 114 FSLYSLVNAFQWIQYSIISNVFEGFYGVTLLHIDWLSMVYMLAYVPLIFPATWLLDTRGLRLTALLGSGLNCLGAWIKCG 193
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7661708 194 SvqqHLFWVTMLGQCLCSVAQVFILGLPSRIASVWFGPKEVSTACATAVLGNQLGTAVGFLLPPVLVPNtqndtnllacn 273
Cdd:cd06174 81 A---PSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASS----------- 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7661708 274 ISTMFYGTSAVATLLFILTAIAFKEKPRYPPSQAQAalQDSPPEEYSYKKSIRNLFKNIPFVLLLITYGIMTGAFYSVST 353
Cdd:cd06174 147 LGFGWRAVFLIAAALALLAAILLLLVVPDPPESARA--KNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFST 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7661708 354 LLNQMILTYYEGEEVNAGRIGLTLVVAGMVGSILCGLWLDYTKtykqTTLIVYILSFIGMVIFTFTLDL-RYIIIVFVTG 432
Cdd:cd06174 225 LLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLI----GRKPLLLIGLLLMALGLALLLLaPSLLLLLLLL 300
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 7661708 433 GVLGFFMTGYLPLGFEFAVEITYPESEGTSSGLLNASAQIFGILFTLAQGKLTSD-YGPKAGNIFLCVWMFIGIILT 508
Cdd:cd06174 301 LLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAAtFGLTGAFLVLAVLLLLAAILL 377
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
105-518 |
4.44e-26 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 110.36 E-value: 4.44e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7661708 105 PRRFVVLLIFSLYSLVNAFQWIQYSIISNVFEGFYGVTLLHIDWLSMVYMLAYVPLIFPATWLLDTRGLRLTALLGSGLN 184
Cdd:COG2223 1 SGRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7661708 185 CLGAWikcGSVQQHLFWVTMLGQCLCSVAQVFILGLPSRIASVWFGPKEVSTACATAVLGNQLGTAVGFLLPPVLvpntq 264
Cdd:COG2223 81 GIGLL---LLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLL----- 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7661708 265 ndtnLLACNISTMFYGTSAVATLLFILTAIAFKEKPRYPPSQAQAALqdsppeeysykKSIRNLFKNIPFVLLLITYGIM 344
Cdd:COG2223 153 ----IAAFGWRNAFLILGILLLVVAVLAWLFLRDPPAGAAAAAKASL-----------RDQLEALRDPRFWLLSLLYFGT 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7661708 345 TGAFYSVSTLLNQMILTYYEGEEVNAGRIGLTLVVAGMVGSILCGLWLDYTKTYKqTTLIVYILSFIGMVIFTFTLDlrY 424
Cdd:COG2223 218 FGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRR-VLLIVFALMALGLLLLALALG--S 294
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7661708 425 IIIVFVTGGVLGFFMTGYLPLGFEFAVEITYPESEGTSSGLLNASAQIFGILFTLAQGKLTSDYG-PKAGNIFLCVWMFI 503
Cdd:COG2223 295 LWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGsYTAAFLVFAVLALV 374
|
410
....*....|....*
gi 7661708 504 GIILTALIKSDLRRH 518
Cdd:COG2223 375 ALVLTLLLYRRPRRA 389
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
101-517 |
6.27e-22 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 97.63 E-value: 6.27e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7661708 101 TALSPRRFVVLLIFSLYSLVNAFQWIQYSIISNVFEGFYGVTLLHIDWLSMVYMLAYVPLIFPATWLLDTRGLRLTALLG 180
Cdd:COG2271 2 RAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7661708 181 SGLNCLGAWIkCGSVQQhlFWVTMLGQCLCSVAQVFILGLPSRIASVWFGPKEVSTACATAVLGNQLGTAVGFLLPPVLV 260
Cdd:COG2271 82 LLLWGLATLL-FGFATS--FWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7661708 261 PNTqndtnllacNISTMFYGTSAVATLLFILTaiafkekpryppsqaqaalqdsppeeysykksirnlfknipFVLLLIT 340
Cdd:COG2271 159 AAF---------GWRAAFLILGLPGLLLALLR-----------------------------------------FWLLALA 188
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7661708 341 YGIMTGAFYSVSTLLNQMILTYYEGEEVNAGRIGLTLVVAGMVGSILCGLWLDYT-KTYKQTTLIVYILSFIGMVIFTFT 419
Cdd:COG2271 189 YFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLgRRRKLVLAIGLLLAALALLLLALL 268
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7661708 420 LDLRYIIIVFVtggVLGFFMTGYLPLGFEFAVEITYPESEGTSSGLLNASAQIFGILFTLAQGKLTSDYGPKAGNIFLCV 499
Cdd:COG2271 269 PSPALAIALLF---LAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAA 345
|
410
....*....|....*...
gi 7661708 500 WMFIGIILTALIKSDLRR 517
Cdd:COG2271 346 LALLAALLALLLLRETRK 363
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
113-478 |
1.97e-18 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 86.70 E-value: 1.97e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7661708 113 IFSLYSLVNAFQWIQYSIISNVFEGFYGVTLLHIDWLSMVYMLAYVPLIFPATWLLDTRGLRLTALLGSGLNCLGAWIkc 192
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLL-- 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7661708 193 gSVQQHLFWVTMLGQCLCSVAQVFILGLPSRIASVWFGPKEVSTACATAVLGNQLGTAVGFLLPPVLVPNTqndtnllac 272
Cdd:pfam07690 79 -LLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLF--------- 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7661708 273 NISTMFYGTSAVATLLFILTAIAFKEKPRYPPSQAQAALQDSPpeeysykkSIRNLFKNIPFVLLLITYGIMTGAFYSVS 352
Cdd:pfam07690 149 GWRAAFLILAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLI--------VAWKALLRDPVLWLLLALLLFGFAFFGLL 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7661708 353 TLLNQMILTYYEGEEVNAGRIGLtLVVAGMVGSILCGLWLDYTKTYKQTTLIV--YILSFIGMVIFTFTLDLRYIIIVFV 430
Cdd:pfam07690 221 TYLPLYQEVLGLSALLAGLLLGL-GGLLGAIGRLLLGRLSDRLGRRRRLLLALllLILAALGLLLLSLTLSSLWLLLALL 299
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 7661708 431 tggVLGFFMTGYLPLGFEFAVEITYPESEGTSSGLLNASAQIFGILFT 478
Cdd:pfam07690 300 ---LLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
101-476 |
1.42e-17 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 84.26 E-value: 1.42e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7661708 101 TALSPRRFVVLLIFSLYSLVNAFQWIQYSIISNVFEGFYGVTLLHIDWLSMVYMLAYVPLIFPATWLLDTRGLRLTALLG 180
Cdd:COG2814 2 PATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7661708 181 SGLNCLGAWIkCGSVQQhlFWVTMLGQCLCSVAQVFILGLPSRIASVWFGPKEVSTACATAVLGNQLGTAVGFLLPPVLV 260
Cdd:COG2814 82 LLLFALGSLL-CALAPS--LWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7661708 261 PNTqndtnllacNISTMFYGTSAVATLLFILTAIAFKEkpryppsqaqaalqDSPPEEYSYKKSIRNLFKNIPFVLLLIT 340
Cdd:COG2814 159 DLF---------GWRWVFLVNAVLALLALLLLLRLLPE--------------SRPAARARLRGSLRELLRRPRLLLLLLL 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7661708 341 YGIMTGAFYSVSTLLNQMILTYYEGEEVNAGRIGLTLVVAGMVGSILCGLWLDYTKtYKQTTLIVYILSFIGMVIFTFTL 420
Cdd:COG2814 216 AFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFG-RRRLLLIGLLLLALGLLLLALAG 294
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 7661708 421 DLRYIIIVFVtggVLGFFMTGYLPLGFEFAVEITYPESEGTSSGLLNASAQIFGIL 476
Cdd:COG2814 295 SLWLLLLALF---LLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPL 347
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
231-445 |
9.55e-13 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 70.32 E-value: 9.55e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7661708 231 PKEVSTACATAVLGNQLGTAVGFLLPPVLVPNTQNDTnllACNISTMFYGTSAVATLLFILTAIAFKEKPRyppsqaqaa 310
Cdd:COG2211 142 YEERTRLSSWRFAFAGLGGLLASVLPPPLVAAFGGDA---ALGYRLTALIFAVLGLLAFLLTFFGTKERPV--------- 209
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7661708 311 lqdSPPEEYSYKKSIRNLFKNIPFVLLLITYGIMTGAFYSVSTLLNQMILTYYEGEEVNAGRIGLTLVVAGMVGSILCGL 390
Cdd:COG2211 210 ---PEEEKVSLKESLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPR 286
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 7661708 391 WLDYTKTyKQTTLIVYILSFIGMVIFTFtLDLRYIIIVFVTGGVLGFFMTGYLPL 445
Cdd:COG2211 287 LAKRFGK-KKAFIIGLLLAALGLLLLFF-LGPGNLWLLLVLAALAGIGLGAILVL 339
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
162-509 |
2.32e-11 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 65.72 E-value: 2.32e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7661708 162 FPATWLLDTRGLRLTALLGSGlnCLGAWIkCGSVQQHLFWVTMLGQCLCSVAQVFILGLPSRIASVWFGPKEVSTACATA 241
Cdd:cd17475 49 LPAGWLLDRFGERRVLAVGLL--LMGAAA-LLMALVGSYPVLLVLLFLVGAGYGSVQPGGGRAIMRWFPPRERGLAMGIR 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7661708 242 VLGNQLGTAVGFLLPPvlvpntqndtnLLACNIS-TMFYGTSAVATLLFILTAIAFKEKPRYPPSQAQAALQDSppeeys 320
Cdd:cd17475 126 QTGVPLGGALAAALLP-----------PLALHYGwRAAFVVAGLVSILAAVLFWLFYREPPAASAATESASTLL------ 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7661708 321 ykKSIRNLFKNIPFVLLLITYGIMTGAFYSVSTLLnqmILTYYEGEEVNAGRIGLTLVVA---GMVGSILCGLWLDYT-- 395
Cdd:cd17475 189 --RSLKEVLRNRDVWLIAIAGALLVAPQFALLTFL---LLFLHDHLGLSVVAAGALLAVAqlgGALGRIGLGRVSDRVfg 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7661708 396 ---KTYKQTTLIVYILSFIGMVIFTFTLDLRYIIIVFVtggVLGFFMTGYLPLGFEFAVEITYPESEGTSSGLLNASAQI 472
Cdd:cd17475 264 grrRPVLVITAAIAAAALLVLSLLSPGTPLWLLVLLLI---LLGLFAIGWNGLYLTLVAESAGPEQAGTALGLANTINFI 340
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 7661708 473 FGILFTLAQGKL---TSDYGPkaGNIFLCVWMFIGIILTA 509
Cdd:cd17475 341 GIAIGPPLFGLLvdaTHSYAP--AWLALALLLVLAALLLL 378
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
93-511 |
5.85e-10 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 61.43 E-value: 5.85e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7661708 93 AESSPLPLTALSPRRFVVLLIFSLYSLVNAFQWIQYSIISNVFEGFYGVTLLHIDWLSMVYMLAYVPLIFPATWLLDTRG 172
Cdd:COG2807 2 STTSSSARRSRRAGRWLLLLAIVLVALNLRPAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7661708 173 LRLTALLGSGLNCLGAWIkcGSVQQHlFWVTMLGQCLCSVAQVFILGLPSRIASVWFgPKEVSTACATAVLGNQLGTAVG 252
Cdd:COG2807 82 LERTLLLALLLLAAGLLL--RSLAPS-VALLLAGTALIGAGIAVGNVLLPGLIKRWF-PDRVGLMTGLYTAAMGLGAALA 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7661708 253 FLLPPVLVPNTqndtnllacNISTMFYGTSAVATLLFILTAIAFKEKPRYPPSQAQAAlqdsppeeysykkSIRNLFKNI 332
Cdd:COG2807 158 AGLTVPLAAAL---------GWRGALAVWALLALLALLLWLPLLRRRPAAAAAAPAAA-------------SLRSLWRSP 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7661708 333 PFVLLLITYGIMTGAFYSVSTLLNQmILTYYEGEEVNAGRIGLTLVVAGMVGSILCGLWLDYTKTYKQTTLIVYILSFIG 412
Cdd:COG2807 216 LAWLLTLFFGLQSLLYYAVVAWLPP-ILRDAGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLAG 294
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7661708 413 MVIFTFT-LDLRYIIIVfvtggVLGFFMTGYLPLGFEFAVEITY-PESEGTSSGLLNASAQIFGILFTLAQGKL---TSD 487
Cdd:COG2807 295 LLGLLLApGSLPWLWAV-----LLGLGQGGLFPLALTLIGLRARtPAEAAALSGMAQSVGYLLAALGPLLVGALhdaTGS 369
|
410 420
....*....|....*....|....
gi 7661708 488 YGpkAGNIFLCVWMFIGIILTALI 511
Cdd:COG2807 370 WT--AALLLLAALAVLMLVAGLLA 391
|
|
| MFS_SLC45_SUC |
cd17313 |
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ... |
243-507 |
1.44e-08 |
|
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340871 [Multi-domain] Cd Length: 421 Bit Score: 56.87 E-value: 1.44e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7661708 243 LGNQLGTAVGFLLppvlvpNTQNDTNLLAC-NISTMFYGTSAVATLLFILTAIAFKEKPRYPPSQAQAALQDSPPEEYSY 321
Cdd:cd17313 152 LGGVLGYLLGAIL------WDHNWFGFALGgNLKVPFYIGAIILLVCVLVTLFFVKEPPLSPEAGEHSENPSLGEVLKSL 225
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7661708 322 KKSIRNLFKNIPFVLLLITYGIMtgAFYSVSTLLNQ-MILTYYEG---------EEVNAGRIGLTLV-VAGMVGSILCGL 390
Cdd:cd17313 226 LKLLKIMPRSLLRLLLVIFFWWI--AFFPFELFFTDyMGEEVYHGtsaasshygAGVRMGAWGLLIFsLAFLIFSLPIGK 303
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7661708 391 WLDYTKTyKQTTLIVYILSFIGMVIFTFTLDLRYIIIVFVTGGVlGFFMTGYLPlgFEFAVEIT--YPESEGTSSGLLNA 468
Cdd:cd17313 304 LGKKIGR-KKVYLIGLVLFAVGMALMALVHNVTVALVLFALGGI-GWATININP--YPLVSDYHseSGRGQGTDTGLLNL 379
|
250 260 270
....*....|....*....|....*....|....*....
gi 7661708 469 SAQIFGILFTLAQGKLTSDYGPKAGNIFLCVWMFIGIIL 507
Cdd:cd17313 380 AISLAQILVSLLAGPIIDVKGYGTVFPVAAVASFLSLVG 418
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
274-512 |
1.02e-06 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 51.04 E-value: 1.02e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7661708 274 ISTMFYGTSAVATLLFILTAIAFKEKPRYPPSQAQAALQDsppeeysyKKSIRNLFKNIPFVLLLITYGIMTGAFYSVST 353
Cdd:cd17325 149 YRAPFLVCAALALLALVLALLLLPEPRPPPNKRAVSAARL--------RSGLRLLLRDRRLLALFLAIFVLAFAFGALEP 220
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7661708 354 LLNqmiLTYYEGEEVNAGRIGLTL---VVAGMVGSILCGlWLDYTKTYKQTTLIVYILSFIGMVIFTFTLDLRYIIIVFV 430
Cdd:cd17325 221 FLP---LYAAELGGLSPAQIGLLFgaqGLASALSQPPAG-KLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLA 296
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7661708 431 tggVLGFFMTGYLPLGFEFAVEITYPESEGTSSGLLNASAQIFGILFTLAQGKLTSDYGPKAGNIFLCVWMFIGIILTAL 510
Cdd:cd17325 297 ---LLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLL 373
|
..
gi 7661708 511 IK 512
Cdd:cd17325 374 LR 375
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
148-509 |
1.76e-06 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 50.24 E-value: 1.76e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7661708 148 WLSMVYMLAYVPLIFPATWLLDTRGLRLTALLGSGLNCLGAWIkCGSVQQhlFWVTMLGQCLCSVAQVFILGLPSRIASV 227
Cdd:cd17324 38 LLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLL-AALAPS--FALLLLARALAGLAHGGFWAIAAAYAAD 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7661708 228 WFGPKEVSTACATAVLGNQLGTAVGFLLPPVLvpntqndTNLLacNISTMFYGTSAVATLLFILTAIAFkekpryPPSQA 307
Cdd:cd17324 115 LVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLL-------GQLL--GWRAAFLAIAVLALLAALLLWRLL------PSLPP 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7661708 308 QAALQdsppeeYSYKKSIRNLFKNIPFVLLLITYGIMTGAFYSVSTLLNQMILtyyEGEEVNAGRIGLTLV---VAGMVG 384
Cdd:cd17324 180 KKPGS------LGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLT---DVPGFSSSAIIGLLLlfgVAGVVG 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7661708 385 SILCGLWLDytKTYKQTTLIVYILSFIGMVIFTFTldLRYIIIVFVTGGVLGFFMTGYLPLGFEFAVEITyPESEGTSSG 464
Cdd:cd17324 251 SPLAGRLAD--RGGRRALLIALLLLAAALLLLTLL--GPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLA-PEARGLASS 325
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 7661708 465 LLNASAQIFGILFTLAQGKLTSDYGPKAGNIFLCVWMFIGIILTA 509
Cdd:cd17324 326 LYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLALLLAL 370
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
106-517 |
5.02e-06 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 49.08 E-value: 5.02e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7661708 106 RRFVVLLIFSLYsLVNAFQWIQYSIISNVFEGFYGVTLLHIDWLSMVYMLAYVPLIFPATWLLDTRGLRLTALLGSGLNC 185
Cdd:COG0738 6 YRRALIAIYLLF-FLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7661708 186 LGAwikCGSVQQHLFWVTMLGqclcsvaqVFILGLPSRIASV-------WFGPKEVSTACATAVLGNQLGTAVGfllpPV 258
Cdd:COG0738 85 LGL---LLFALAPSYPLLLLA--------LFLLGLGLGLLDVaanpyvaALGPETAASRLNLLHAFFSLGALLG----PL 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7661708 259 LVpntqndTNLLACNISTMFYGTSAVATLLFILTAIAFKeKPRYPPSQAQAAlqdsppEEYSYKKSIRNLFKNIPFVLLL 338
Cdd:COG0738 150 LG------GLLILLGLSLSWHLPYLILAVLLLLLALLFL-RSKLPEIEEEEE------EAAGSAASLKSLLKNPRLLLGG 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7661708 339 ITYGIMTGAFYSVSTLLNQMILTYYEGEEVNAGRIGLTLVVAGMVGSILCGLWLDYtktYKQTTLIVY--ILSFIGMVIF 416
Cdd:COG0738 217 LAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKR---FGPVRLLRLsaLLAAVGLLLA 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7661708 417 TFTLDLRYIIIVFVtggVLGFFMTGYLPLGFEFAVEItYPESEGTSSGLLNASAQIFGILFTLAQGKLTSDYGPKAGNIF 496
Cdd:COG0738 294 LLAPGPWLALIGLA---LVGLGLSLMFPTIFSLALDG-LGKRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLV 369
|
410 420
....*....|....*....|.
gi 7661708 497 LCVWMFIGIILTALIKSDLRR 517
Cdd:COG0738 370 PLVCYLLILLLALALKRKRRK 390
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
111-507 |
2.68e-05 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 46.48 E-value: 2.68e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7661708 111 LLIFSLYSLVNAFQWIQYSIISNVFEGFYGVTLLHIDWLSMVYMLAYVPLIFPATWLLDTRGLRLTALLGSGLN---CLG 187
Cdd:cd17341 1 LHLSWLSFFLGFMVWFLFAPLGPVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLlipLLA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7661708 188 AWIKCGSVQQHLFWVTMLGQCLCSvaqvFILGLPSriASVWFGPKEVSTACATAVLGNQLGTAVGFLLPPVLVPNTQNDT 267
Cdd:cd17341 81 LALAVSSYWGLLVLGFLLGFAGAN----FASGQPW--ASFWFPKEKIGGAAGGIAGAGNMGVAVSQLLAPLIAGAIVFDG 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7661708 268 NLLAcnistmFYGTSAVATLLFILTAIAFKEKPRYPPSQAQAALQDSPPeeysykksIRNLFKNIPFVLLLITYGIMTGA 347
Cdd:cd17341 155 GFVG------WRNAFFVPGILLAIAAVLVLLFGDDLPTGKASALEFLKV--------QLAVLKNYRTWILSLLYGVTFGS 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7661708 348 FYSVSTLLNQMILTYYEGEEVNAGRIGLTLVVAGMVGSILCGLWLDYTKtYKQTTLIVYILSFIGMVIFTFTL-DLRYII 426
Cdd:cd17341 221 FVGFSNVLPTYFKTRFGLPLVTAGILAALFPLAGALARPAGGWLSDRFG-GRRRLWWLFIVMTIGAALLSLSLpTSGTNL 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7661708 427 IVFVTGGVLGFFMTGyLPLGFEFA-VEITYPESEGTSSGLLNASAQIFGILFTLAQGKLTSDYGPKAGNIFLCVWMFIGI 505
Cdd:cd17341 300 VLFLALFVALGLGAG-AGNGSVFRmVPFIFRRELGAVTGLVGAIGGLGGFFLPLLFGSSALMTGSGVGAFSLFGVLAVAC 378
|
..
gi 7661708 506 IL 507
Cdd:cd17341 379 TL 380
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
166-510 |
9.20e-05 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 44.95 E-value: 9.20e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7661708 166 WLLDTRGLRLTALLGSGLNCLG----AWIKCGSVQQHLFWVTMLGQCLCSVAqvfilGLPSRIASVWFGPKEvSTACATA 241
Cdd:cd17355 60 RLLDRFGPRRVMLLGLLLLAAGlvllALATSLWQLYLLWGLLGGGGAGTLAA-----VAFATVAAWWFERRR-GLALGIL 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7661708 242 VLGNQLGtavGFLLPPVLVPNTQNDTNLLACNISTMFYGTSAVATLLFILtaiafkekpRYPPSQAQAAlqDSPPEEYSY 321
Cdd:cd17355 134 TAGGGLG---SLVFLPLGAALIEAFGWRTALLVLALLALLVLVPVLLLLR---------RRPADLALRA--YDDASPASP 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7661708 322 KKSIRNLFKNIPFVLLLITYGIMTGAFYSVSTLLNQMILTYYEGEEVNAGRIGLtLVVAGMVGSILCGLWLD-YTKTYkq 400
Cdd:cd17355 200 GSTLKEALRSASFWLLALAFFLCGFAVVGLIVHLVPYLADRGISPAAAAVALAL-IGLFNIVGRLLSGWLGDrYSPRR-- 276
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7661708 401 TTLIVYILSFIGMVIFTFTLDLRYIIIVFVtgGVLGFFMTGYLPLGFEFAVEITYPESEGTSSGLLNASAQIFGILFTLA 480
Cdd:cd17355 277 LLAASYALRALGLALLLLLPFPPLALLLFA--ALFGLGWGATVPLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWL 354
|
330 340 350
....*....|....*....|....*....|
gi 7661708 481 QGKLTSDYGPKAGNIFLCVWMFIGIILTAL 510
Cdd:cd17355 355 GGLLYDRTGSYTAAWALAVALGLIAALLVL 384
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
278-509 |
1.06e-04 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 44.47 E-value: 1.06e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7661708 278 FYGTSAVATLLFILTAIAFKEKPRYPPSQAQAALQdsppeeysyKKSIRNLFKNIPFVLLLITYGIM--TGAFYSVSTLL 355
Cdd:cd17478 148 GLGLLILLIIPGLAVALLLLRLRPLKKPEAKKAAA---------KSSARSTLKGVWRALLLLLIIVFlrSWVLSSLTTFL 218
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7661708 356 NQMiLTYYEGEEVNAGRIGLTLVVAGMVGSILCGLWLDYtktYKQTTLIvyILSFIGMVIFTFTLDLRYIIIVFVTGGVL 435
Cdd:cd17478 219 PFY-LVQRGYSLVFAGLLLSLFLFAGAIGTLIGGPLSDR---FGRRRVI--IASLLLAAPFLLLFLLTPGIWSYILLVLA 292
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 7661708 436 GFFMTGYLPLGFEFAVEITyPESEGTSSGLLNASAQIFGILFTLAQGKLTSDYGPKAGNIFLCVWMFIGIILTA 509
Cdd:cd17478 293 GFLLFASFPVTVVLAQELL-PGNVGLASGLMMGLSFGLGGIGAPVLGALADAFGLESVLLILALLPLLGALLAF 365
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
231-447 |
1.16e-04 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 44.52 E-value: 1.16e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7661708 231 PKEVSTACATAVLGNQLGTAVGFLLPPVLVPNTQNDtnllacNISTMFYGTSAV-ATLLFILTAIAFKE-KPRYPPSQAq 308
Cdd:cd17332 131 PEERTSLTSWRMFFATIGGLLVTVLPPPLVAYFGGG------NASRGYFLTALIiGIIGIILLLICFFGtRERVVPPEE- 203
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7661708 309 aalqdsPPEEYSYKKSIRNLFKNIPFVLLLITYGIMTGAFYSVSTLLNqMILTYYEGEEVNAGRIGLTLVVAGMVGSILC 388
Cdd:cd17332 204 ------EKSKLPLLKSLKALLKNRPFLILLLAYLLYFLAFNIVNTVLV-YYFKYVLGGRAELVLLLLLILSGALLALLPW 276
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 7661708 389 GL---WLDYTKTYKqTTLIVYILSFIGMviftFTLDLRYIIIVFVTGGVLGFFMTGYLPLGF 447
Cdd:cd17332 277 PPlkkRFGKKKAFF-IGLLLAILGLLLL----FFLPPGNLVLILVLAVLAGIGYGGANLLPW 333
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
148-511 |
1.58e-04 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 44.10 E-value: 1.58e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7661708 148 WLSMVYMLAYVPLIFPATWLLDTRGLRLTALLgsglnCLGAWikcGSVQQHLFWVTMLGQCLcsVAQvFILGL------P 221
Cdd:cd17319 42 LIASAFFLGYALFQVPGGWLLDRFGARKVLAV-----SMLLW---SLFTALTGFATSLTSLY--VLR-FLLGVaeagffP 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7661708 222 --SRIASVWFGPKEVSTACATAVLGNQLGTAVGFLLPPVLvpntqndtnLLACNISTMFYGTSAVATLLFILTAIAFKEk 299
Cdd:cd17319 111 gaIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWL---------LLLFGWRWAFIIEGLLGLLLAVLWWFYLRQ- 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7661708 300 pryppsqaqaalqdsppeeysykksirnlfknipFVLLLITYGIMTGAFYSVSTLLNQMILTYYEGEEVNAGRIGLTLVV 379
Cdd:cd17319 181 ----------------------------------VWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFL 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7661708 380 AGMVGSILCGLWLDYTKTYKQTTLIVYILSF-IGMVIFTFTLDLRYIIIVFVTGGvlGFFMTGYLPLGFEFAVEITYPES 458
Cdd:cd17319 227 AGAIGMILGGRLSDRLLRGARRLVIIIGLLLaAVGLLLAYLTTSPVVAVILLSLA--GFGIGAASPVFWSLPADLLPGEA 304
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 7661708 459 EGTSSGLLNASAQIFGILFTLAQGKL-TSDYGPKAGNIFLCVWMFIGIILTALI 511
Cdd:cd17319 305 AATAGGLINSGGNLGGFVAPLLIGYLvDATGSYTAAFLFLAAVALLAALLVLLL 358
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
334-510 |
1.69e-04 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 44.13 E-value: 1.69e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7661708 334 FVLLLITYGIMTGAFYSVSTLLNQMILTYYEGEEVNAGRIGLTLVVAGMVGSILCGLWLDYTkTYKQTTLIVYILSFIGM 413
Cdd:cd17316 179 TLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRI-GRKKTLVIGLILSGILA 257
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7661708 414 VIFTFTLDLrYIIIVFVTGGVLGFFMTGYLPLGFEFAVEITYPESEGTSSGLLNASAQIFGILFTLAQGKLTSDYGPKAG 493
Cdd:cd17316 258 LPLFYLLSG-SPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGV 336
|
170
....*....|....*..
gi 7661708 494 NIFLCVWMFIGIILTAL 510
Cdd:cd17316 337 PALILALLAIVALIVAL 353
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
328-478 |
7.92e-04 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 42.23 E-value: 7.92e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7661708 328 LFKNIPFVLLLITYGIMTGAFYSVSTLLNQMILTYYEGEEVNAGRIGLTLVVAGMVGSILCGLWLDYTKTYKqTTLIVYI 407
Cdd:cd06179 258 LFRGRNFALILIVAFVEGMIFYSLNIFWPQQISLLFTTDPLKAGLYQLPFGLGTLFGAILAGLLLTKIKHIK-WQLVAGF 336
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 7661708 408 LSFIGMVIFTFTLD----LRYIIIVFVTGGVLGFFMTgylpLGFEFAVEITYPESEGTSSGLLNASAQIFGILFT 478
Cdd:cd06179 337 VLFTAFLALLALITpdnkALAIAFSVLAGIGIGGPLV----LAIVIVQLSVPPEDIGTASGLLGSARALGGAVGT 407
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
276-487 |
1.20e-03 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 41.41 E-value: 1.20e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7661708 276 TMFYGTSAVATLLFILTAIAFKEKPrypPSQAQAALQDSPPEEYsykksiRNLFKNIPFVLLLITYGIMTGAFYSVSTLL 355
Cdd:cd17320 154 AIFVFLALLGLLLLLLVLLFLPETL---PEEKRKPLLSSLLRAY------KRVLKNRRFLGYALALGLSFAGLFAYLAAA 224
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7661708 356 NQMILTYYEGEEVNAGRIGLTLVVAGMVGSILCGLWLDYTKTYKQTTLIVYILSFIGMVIFTFTLDLRYIIIVFVTGGVL 435
Cdd:cd17320 225 PFIYIEQLGLSPAQFGLLFALNAIALILGSLLNGRLVRRFGPRRLLRLGLLLLLAAALVLLLAALLGGLSLWPLVAPLFL 304
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 7661708 436 GFFMTGYL-PLGFEFAVEItYPESEGTSSGLLNASAQIFGILFTLAQGKLTSD 487
Cdd:cd17320 305 IFFGFGLIfPNATSLALEP-FPHVAGTASALLGFLQFLIGALAGALVGLLPNG 356
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
328-511 |
3.37e-03 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 39.84 E-value: 3.37e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7661708 328 LFKNIPFVLLLIT-----YGIMTGAFYSVSTLLNQmiltyyeGEEVNAGRIGLTLV-VAGMVGSILCGLWLDYTKTYKQT 401
Cdd:cd17352 179 LLKDPTFVLLALGvsfamLGFFVPFVYLPSYAKSL-------GIDESDAAFLLSIIgISDIVGRILLGLLADKPRIGRLY 251
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7661708 402 TLIVYILsFIGMVIFTFTLDLRYIIIVFVtGGVLGFFMTGYLPLGFEFAVEITYPESEGTSSGLLNASAQIFGILFTLAQ 481
Cdd:cd17352 252 LYIFTLL-ILGLSLLAFPLATTYVGLIVF-SVLFGFCSGSYSSLTPVILADLVGLEKLSNAYGLVLLFQGLAALVGPPIA 329
|
170 180 190
....*....|....*....|....*....|.
gi 7661708 482 GKLTSDYGP-KAGNIFLCVWMFIGIILTALI 511
Cdd:cd17352 330 GLLRDYTGDyDAAFYFCGACLLLSGVLLFLL 360
|
|
| MFS_2 |
pfam13347 |
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ... |
231-438 |
4.12e-03 |
|
MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.
Pssm-ID: 433134 [Multi-domain] Cd Length: 427 Bit Score: 39.60 E-value: 4.12e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7661708 231 PKEVSTACATAVLGNQLGTAVGFLLPPVLV-PNTQNDTNLLACNISTMFYgtSAVATLLFILTAIAFKEKPRYPPsqAQA 309
Cdd:pfam13347 129 YDERTSLTSYRSFFSVGGGLLAAALAFPLVlILGGTGLERKGYRIFALIG--AVLMLLGVIITAAGTKERVSMRS--KED 204
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7661708 310 ALQDSPPeeySYKKSIRNLFKNIPFVLLLITYGIMTGAfYSVSTLLNQMILTYYEGEEVNAGrIGLTLVVAGMVGSILcg 389
Cdd:pfam13347 205 TGQKEAG---SLLDMLKEVFRNRAFLILLASFLLAALA-MGVLNGLLLYYFRYVLGNGFAAS-AFPLVFTIGALLGIP-- 277
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 7661708 390 LWLDYTKTY--KQTTLIVYILSFIGMVIFtFTLDLRYIIIVFVTGGVLGFF 438
Cdd:pfam13347 278 LWPPLAKRIgkKNTYILGALITIAGFALA-LLLGPNNTLLFLVLYIIIGFG 327
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
379-489 |
6.60e-03 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 38.90 E-value: 6.60e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7661708 379 VAGMVGSILCGlWL---DYTKTYKQTTLIVYILSFIGMVIFTFTLDLRYIIIVfVTGGVLGFFMTGYLPLGFEFAVEITY 455
Cdd:TIGR00881 263 LGGLVGTLLAG-WLsdkLFNGRRGPLAVFFMALIIVSLLVYWLNPAANPLMDL-ICLFALGFLVYGPQMLIGVIASELAP 340
|
90 100 110
....*....|....*....|....*....|....
gi 7661708 456 PESEGTSSGLLNASAQIFGILFTLAQGKLTSDYG 489
Cdd:TIGR00881 341 KKAAGTAAGFVGFFAYLGGILAGLPLGYLADGFG 374
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
228-511 |
7.10e-03 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 38.79 E-value: 7.10e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7661708 228 WFGPKEVSTACATAVLGNQLGTAVGFLLPPVLVpntqndtnlLACNISTMFYGTSAVATLLFILTAIAFKEKPRYppsqa 307
Cdd:cd17312 119 WFSKKERGTVYGIWSTSHNFGGILAPILAASLA---------SYYGWRAAFLVPGIVGLVVAIILFFFLRDSPPY----- 184
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7661708 308 qaalqdsppeeysykksirnlfknipFVLLLITYGIMTGAFYSVSTLLNQMILTYYEGEEVNAGRIGLTLVVAGMVGSIL 387
Cdd:cd17312 185 --------------------------VWVLSLAYAFVYIVRYACLDWGPLYLYEVKGYSLIDAGWFSSLYEVGGIAGTIL 238
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7661708 388 CGLWLDytKTYKQTTLIVYILSFIGMV----IFTFTLDLRYIIIVFVTggVLGFFMTG-YLPLGFEFAVEITYPESEGTS 462
Cdd:cd17312 239 AGLLSD--KLFGGRRAPIAVIYMLLMTlslaLFWFFPHNKLLSIVLLF--LIGFFVGGpINLIGGAAAQDIGRKEAAGTA 314
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 7661708 463 SGLLNASAQIFGILFTLAQGKLTSDYGPKAGNIFlcvWMFIGIILTALI 511
Cdd:cd17312 315 TGFVGLFGYLGASLAGLPLGYIIDHYGWSTVFYF---LISAALLSVLLL 360
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
106-511 |
7.77e-03 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 38.75 E-value: 7.77e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7661708 106 RRFVVLLIFSLYSLVNAFQWIqYSIISNVFEGFYGVTLLHIDWLSMVYMLAYVPLIFPATWLLDTRGLRLTALLGSGLNC 185
Cdd:cd17353 1 RRWLVLLGAVLMHLILGYQYA-WSVFNPPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7661708 186 LGaWIkCGSVQQHLFWVTMLGQCLCSVAQVFILGLPSRIASVWFgPKEVSTACATAVLGNQLGTAVgFLLPPVLVPNTQn 265
Cdd:cd17353 80 LG-FI-LSAFAISLPLLFLGYGVLGGIGAGIGYITPVSTAVKWF-PDKRGLATGIVIAGFGLGSLI-FSPLIAYLINTV- 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7661708 266 dtnllacNISTMFYGTSAVATLLFILTAIAFKEKPRyPPSQAQAALQDSPPEEYSYKKSIRNLFKNIPFVLLLITYGIMT 345
Cdd:cd17353 155 -------GVPTTFLILGIIFLIIIVIGAFLIRDPPK-GWVPPGVDPLANNAENSPRDYTPREMLRTPTFWLLWLMFFLNA 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7661708 346 GAFYSVSTLLNQMiltyyeGEEVnagrIGLTLVVAGMVGSILC----------GLWLDYTKtYKQTTLIVYILSFIGMVI 415
Cdd:cd17353 227 TAGLMLIGQAKPI------GQEF----AGLDAGIAALAVSILSifngggrpfwGWLSDKIG-RKNTLSIAFLIQGVAMFL 295
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7661708 416 FTFTLDLRYIIIVFVtgGVLGFFMTGYLPLGFEFAVEITYPESEGTSSGLLNASAQIFGILFTLAQGKLTSDYGPKAGNI 495
Cdd:cd17353 296 LPFIGSVAVLFVLGV--ALIGFCYGGGFALFPALTADFFGTKNAGTNYGLLYTAKGVGGLIGPIIAAYVLYTGGYNAAFI 373
|
410
....*....|....*.
gi 7661708 496 FLCVWMFIGIILTALI 511
Cdd:cd17353 374 IAAALSLVALALALLL 389
|
|
| |
