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Conserved domains on  [gi|34328219|ref|NP_038751|]
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podocalyxin precursor [Mus musculus]

Protein Classification

Herpes_BLLF1 and CD34_antigen domain-containing protein( domain architecture ID 13557104)

Herpes_BLLF1 and CD34_antigen domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CD34_antigen pfam06365
CD34/Podocalyxin family; This family consists of several mammalian CD34 antigen proteins. The ...
 301-503 2.03e-88

CD34/Podocalyxin family; This family consists of several mammalian CD34 antigen proteins. The CD34 antigen is a human leukocyte membrane protein expressed specifically by lymphohematopoietic progenitor cells. CD34 is a phosphoprotein. Activation of protein kinase C (PKC) has been found to enhance CD34 phosphorylation. This family contains several eukaryotic podocalyxin proteins. Podocalyxin is a major membrane protein of the glomerular epithelium and is thought to be involved in maintenance of the architecture of the foot processes and filtration slits characteriztic of this unique epithelium by virtue of its high negative charge. Podocalyxin functions as an anti-adhesin that maintains an open filtration pathway between neighbouring foot processes in the glomerular epithelium by charge repulsion.


:

Pssm-ID: 461884  Cd Length: 211  Bit Score: 270.08  E-value: 2.03e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328219   301 ILNLTRASLCERSPLDEKEKLVELLCHSVKASFKPAEDLCTLHVAPILDNQAVAVKRIIIETKLSPKAVYELLKDRWDDL 380
Cdd:pfam06365   1 ILNLNETSDCEDFKKEKGEDLLQVLCRAFSATFNSPQDVCSILLAKSEENDQCLLLTLANETGLPPKAVLELLKDKRRDL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328219   381 TEAGVSDMKLGKEGPPEVN--EDRFSLPLIITIVC--MASFLLLVAALYGCCHQRISQRKDQQRLTEELQTVENGYHDNP 456
Cdd:pfam06365  81 EELGIQNFTYGTECQEEDVqsHQDYSKLTLIALVTsgILLAILLVAGYYGCLHRRRSKSKAGERLGEELQTVENGYHDNP 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 34328219   457 TLEVME-TPSEMQEK----KVVNLNGElgDSWIVPLDNLTKDDLD-EEEDTHL 503
Cdd:pfam06365 161 TLSVAPdTQSEMQEKpsvnGGAQENGT--GSWIVPLSRNGHSDRQhVEEDTHL 211
Chi1 super family cl43877
Chitinase [Carbohydrate transport and metabolism];
23-194 5.77e-08

Chitinase [Carbohydrate transport and metabolism];


The actual alignment was detected with superfamily member COG3469:

Pssm-ID: 442692 [Multi-domain]  Cd Length: 534  Bit Score: 55.14  E-value: 5.77e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328219  23 NGNETSTSAIKSSTVQSHQSATTSTEVTTGHPVASTLASTQPSNPTPFTTSTQSPSMPTSTPNPTSNQSGGNLTSSVSev 102
Cdd:COG3469  41 TVVSTTGSVVVAASGSAGSGTGTTAASSTAATSSTTSTTATATAAAAAATSTSATLVATSTASGANTGTSTVTTTSTG-- 118

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328219 103 DKTKTSSPSSTAFTSSSGQTASSGGKSGDSFTTAPTTTLGLINVSSQPTDLNTTSKLLSTPTTDNTTSPQQPVDSSPSTA 182
Cdd:COG3469 119 AGSVTSTTSSTAGSTTTSGASATSSAGSTTTTTTVSGTETATGGTTTTSTTTTTTSASTTPSATTTATATTASGATTPSA 198

                       170
                ....*....|..
gi 34328219 183 SHPVGQHTPAAV 194
Cdd:COG3469 199 TTTATTTGPPTP 210
 
Name Accession Description Interval E-value
CD34_antigen pfam06365
CD34/Podocalyxin family; This family consists of several mammalian CD34 antigen proteins. The ...
 301-503 2.03e-88

CD34/Podocalyxin family; This family consists of several mammalian CD34 antigen proteins. The CD34 antigen is a human leukocyte membrane protein expressed specifically by lymphohematopoietic progenitor cells. CD34 is a phosphoprotein. Activation of protein kinase C (PKC) has been found to enhance CD34 phosphorylation. This family contains several eukaryotic podocalyxin proteins. Podocalyxin is a major membrane protein of the glomerular epithelium and is thought to be involved in maintenance of the architecture of the foot processes and filtration slits characteriztic of this unique epithelium by virtue of its high negative charge. Podocalyxin functions as an anti-adhesin that maintains an open filtration pathway between neighbouring foot processes in the glomerular epithelium by charge repulsion.


Pssm-ID: 461884  Cd Length: 211  Bit Score: 270.08  E-value: 2.03e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328219   301 ILNLTRASLCERSPLDEKEKLVELLCHSVKASFKPAEDLCTLHVAPILDNQAVAVKRIIIETKLSPKAVYELLKDRWDDL 380
Cdd:pfam06365   1 ILNLNETSDCEDFKKEKGEDLLQVLCRAFSATFNSPQDVCSILLAKSEENDQCLLLTLANETGLPPKAVLELLKDKRRDL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328219   381 TEAGVSDMKLGKEGPPEVN--EDRFSLPLIITIVC--MASFLLLVAALYGCCHQRISQRKDQQRLTEELQTVENGYHDNP 456
Cdd:pfam06365  81 EELGIQNFTYGTECQEEDVqsHQDYSKLTLIALVTsgILLAILLVAGYYGCLHRRRSKSKAGERLGEELQTVENGYHDNP 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 34328219   457 TLEVME-TPSEMQEK----KVVNLNGElgDSWIVPLDNLTKDDLD-EEEDTHL 503
Cdd:pfam06365 161 TLSVAPdTQSEMQEKpsvnGGAQENGT--GSWIVPLSRNGHSDRQhVEEDTHL 211
Chi1 COG3469
Chitinase [Carbohydrate transport and metabolism];
23-194 5.77e-08

Chitinase [Carbohydrate transport and metabolism];


Pssm-ID: 442692 [Multi-domain]  Cd Length: 534  Bit Score: 55.14  E-value: 5.77e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328219  23 NGNETSTSAIKSSTVQSHQSATTSTEVTTGHPVASTLASTQPSNPTPFTTSTQSPSMPTSTPNPTSNQSGGNLTSSVSev 102
Cdd:COG3469  41 TVVSTTGSVVVAASGSAGSGTGTTAASSTAATSSTTSTTATATAAAAAATSTSATLVATSTASGANTGTSTVTTTSTG-- 118

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328219 103 DKTKTSSPSSTAFTSSSGQTASSGGKSGDSFTTAPTTTLGLINVSSQPTDLNTTSKLLSTPTTDNTTSPQQPVDSSPSTA 182
Cdd:COG3469 119 AGSVTSTTSSTAGSTTTSGASATSSAGSTTTTTTVSGTETATGGTTTTSTTTTTTSASTTPSATTTATATTASGATTPSA 198

                       170
                ....*....|..
gi 34328219 183 SHPVGQHTPAAV 194
Cdd:COG3469 199 TTTATTTGPPTP 210
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 27-295 4.22e-05

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 46.45  E-value: 4.22e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328219    27 TSTSAIKSSTVQSHQSATTSTEVTTGHPVASTLASTQPSNPTPF-TTSTQSPSMPTSTPNPTSNQSGG-NLTSSVSEVDK 104
Cdd:pfam05109 436 TTGFAAPNTTTGLPSSTHVPTNLTAPASTGPTVSTADVTSPTPAgTTSGASPVTPSPSPRDNGTESKApDMTSPTSAVTT 515

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328219   105 TKTSSPSSTAFTSSSGQTASS---GGKSGDSFTTAPTTTlglinvSSQPTDLNTTSKLLSTPTTDNTTSPQQPVDS-SPS 180
Cdd:pfam05109 516 PTPNATSPTPAVTTPTPNATSptlGKTSPTSAVTTPTPN------ATSPTPAVTTPTPNATIPTLGKTSPTSAVTTpTPN 589

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328219   181 TASHPVGQHTPAAVPSSSGSTPSTDNSTLTwKPTTHKPLGTSEATQPLTSQTPGITTLPVSTLQQSMASTVGTTTEEFTH 260
Cdd:pfam05109 590 ATSPTVGETSPQANTTNHTLGGTSSTPVVT-SPPKNATSAVTTGQHNITSSSTSSMSLRPSSISETLSPSTSDNSTSHMP 668

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 34328219   261 LISNGTPVAPPGPSTPSPIWAFGNYQLNCEPPIRP 295
Cdd:pfam05109 669 LLTSAHPTGGENITQVTPASTSTHHVSTSSPAPRP 703
PHA03247 PHA03247
large tegument protein UL36; Provisional
 54-278 3.18e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.77  E-value: 3.18e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328219    54 PVASTLASTQPSNPTPFTTSTQSPSMPTSTPNPTSNQSGGNLTSSVSEVDKTKTSSPSSTAftSSSGQTASSGGKSGDSF 133
Cdd:PHA03247 2601 PVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRV--SRPRRARRLGRAAQASS 2678

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328219   134 TT------APTTTLGLINVSSQPTDLNTTSKLLSTPTTDNTTSPQQPVDSSPSTASHPVGQHTPAAVPSSSGSTPSTDNS 207
Cdd:PHA03247 2679 PPqrprrrAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPA 2758

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328219   208 TltwKPTTHKPLGTSEATQPLTSQTPGITTLPVSTLQQSMAS------------TVGTTTEEFTHLISNGTPVAPPGPST 275
Cdd:PHA03247 2759 R---PPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESlpspwdpadppaAVLAPAAALPPAASPAGPLPPPTSAQ 2835


                  ...
gi 34328219   276 PSP 278
Cdd:PHA03247 2836 PTA 2838
ser_rich_anae_1 NF033849
serine-rich protein; This serine-rich protein belongs to a family with large size (over 1000 ...
 41-187 6.83e-04

serine-rich protein; This serine-rich protein belongs to a family with large size (over 1000 amino acids), which a highly serine-rich central region that averages over 300 aa in length. Species encoding members of this family of proteins tend to be anaerobic bacteria, including Gram-positive bacteria of the human gut microbiome and Chloroflexi from marine sediments.


Pssm-ID: 468206 [Multi-domain]  Cd Length: 1122  Bit Score: 42.30  E-value: 6.83e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328219    41 QSATTSTEVTTGHPVASTLAST--QPSNPTPFTTSTQSPSMPTSTPNPTSNQSGGNLTSSVSEVDKTKTSSPSSTAFTSS 118
Cdd:NF033849  237 QSAGTGYGESVGHSTSQGQSHSvgTSESHSVGTSQSQSHTTGHGSTRGWSHTQSTSESESTGQSSSVGTSESQSHGTTEG 316

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 34328219   119 SGQTASSGGKSGDSFTTAPTTtlgliNVSSQPTDLNTTSKLLSTPTTDNTTSPQQPVDSSPSTASHPVG 187
Cdd:NF033849  317 TSTTDSSSHSQSSSYNVSSGT-----GVSSSHSDGTSQSTSISHSESSSESTGTSVGHSTSSSVSSSES 380
ser_rich_anae_1 NF033849
serine-rich protein; This serine-rich protein belongs to a family with large size (over 1000 ...
 35-142 9.73e-03

serine-rich protein; This serine-rich protein belongs to a family with large size (over 1000 amino acids), which a highly serine-rich central region that averages over 300 aa in length. Species encoding members of this family of proteins tend to be anaerobic bacteria, including Gram-positive bacteria of the human gut microbiome and Chloroflexi from marine sediments.


Pssm-ID: 468206 [Multi-domain]  Cd Length: 1122  Bit Score: 38.83  E-value: 9.73e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328219    35 STVQSH---QSATTSTEVTTGHPVASTLASTQPSNPTPFTTSTQSPSMPTSTPNPTSNQSGGNLTSSVSEVDKTKTSSPS 111
Cdd:NF033849  252 SQGQSHsvgTSESHSVGTSQSQSHTTGHGSTRGWSHTQSTSESESTGQSSSVGTSESQSHGTTEGTSTTDSSSHSQSSSY 331

                          90       100       110
                  ....*....|....*....|....*....|.
gi 34328219   112 STAFTSSSGQTASSGGKSGDSFTTAPTTTLG 142
Cdd:NF033849  332 NVSSGTGVSSSHSDGTSQSTSISHSESSSES 362
 
Name Accession Description Interval E-value
CD34_antigen pfam06365
CD34/Podocalyxin family; This family consists of several mammalian CD34 antigen proteins. The ...
 301-503 2.03e-88

CD34/Podocalyxin family; This family consists of several mammalian CD34 antigen proteins. The CD34 antigen is a human leukocyte membrane protein expressed specifically by lymphohematopoietic progenitor cells. CD34 is a phosphoprotein. Activation of protein kinase C (PKC) has been found to enhance CD34 phosphorylation. This family contains several eukaryotic podocalyxin proteins. Podocalyxin is a major membrane protein of the glomerular epithelium and is thought to be involved in maintenance of the architecture of the foot processes and filtration slits characteriztic of this unique epithelium by virtue of its high negative charge. Podocalyxin functions as an anti-adhesin that maintains an open filtration pathway between neighbouring foot processes in the glomerular epithelium by charge repulsion.


Pssm-ID: 461884  Cd Length: 211  Bit Score: 270.08  E-value: 2.03e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328219   301 ILNLTRASLCERSPLDEKEKLVELLCHSVKASFKPAEDLCTLHVAPILDNQAVAVKRIIIETKLSPKAVYELLKDRWDDL 380
Cdd:pfam06365   1 ILNLNETSDCEDFKKEKGEDLLQVLCRAFSATFNSPQDVCSILLAKSEENDQCLLLTLANETGLPPKAVLELLKDKRRDL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328219   381 TEAGVSDMKLGKEGPPEVN--EDRFSLPLIITIVC--MASFLLLVAALYGCCHQRISQRKDQQRLTEELQTVENGYHDNP 456
Cdd:pfam06365  81 EELGIQNFTYGTECQEEDVqsHQDYSKLTLIALVTsgILLAILLVAGYYGCLHRRRSKSKAGERLGEELQTVENGYHDNP 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 34328219   457 TLEVME-TPSEMQEK----KVVNLNGElgDSWIVPLDNLTKDDLD-EEEDTHL 503
Cdd:pfam06365 161 TLSVAPdTQSEMQEKpsvnGGAQENGT--GSWIVPLSRNGHSDRQhVEEDTHL 211
Chi1 COG3469
Chitinase [Carbohydrate transport and metabolism];
23-194 5.77e-08

Chitinase [Carbohydrate transport and metabolism];


Pssm-ID: 442692 [Multi-domain]  Cd Length: 534  Bit Score: 55.14  E-value: 5.77e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328219  23 NGNETSTSAIKSSTVQSHQSATTSTEVTTGHPVASTLASTQPSNPTPFTTSTQSPSMPTSTPNPTSNQSGGNLTSSVSev 102
Cdd:COG3469  41 TVVSTTGSVVVAASGSAGSGTGTTAASSTAATSSTTSTTATATAAAAAATSTSATLVATSTASGANTGTSTVTTTSTG-- 118

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328219 103 DKTKTSSPSSTAFTSSSGQTASSGGKSGDSFTTAPTTTLGLINVSSQPTDLNTTSKLLSTPTTDNTTSPQQPVDSSPSTA 182
Cdd:COG3469 119 AGSVTSTTSSTAGSTTTSGASATSSAGSTTTTTTVSGTETATGGTTTTSTTTTTTSASTTPSATTTATATTASGATTPSA 198

                       170
                ....*....|..
gi 34328219 183 SHPVGQHTPAAV 194
Cdd:COG3469 199 TTTATTTGPPTP 210
Chi1 COG3469
Chitinase [Carbohydrate transport and metabolism];
23-180 1.13e-07

Chitinase [Carbohydrate transport and metabolism];


Pssm-ID: 442692 [Multi-domain]  Cd Length: 534  Bit Score: 54.37  E-value: 1.13e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328219  23 NGNETSTSAIKSSTVQSHQSATTSTEVTTGHPVASTLASTQPSNPTPFTTSTQSPSMPTSTPNPTSNQSGGNLTSSVSEV 102
Cdd:COG3469  58 GSGTGTTAASSTAATSSTTSTTATATAAAAAATSTSATLVATSTASGANTGTSTVTTTSTGAGSVTSTTSSTAGSTTTSG 137

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 34328219 103 DKTKTSSPSSTAFTSSSGQTASSGGKSGDSFTTAPTTTLGLINVSSQPTDlNTTSKLLSTPTTDNTTSPQQPVDSSPS 180
Cdd:COG3469 138 ASATSSAGSTTTTTTVSGTETATGGTTTTSTTTTTTSASTTPSATTTATA-TTASGATTPSATTTATTTGPPTPGLPK 214
Chi1 COG3469
Chitinase [Carbohydrate transport and metabolism];
72-278 7.86e-07

Chitinase [Carbohydrate transport and metabolism];


Pssm-ID: 442692 [Multi-domain]  Cd Length: 534  Bit Score: 51.68  E-value: 7.86e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328219  72 TSTQSPSMPTSTPNPTSNQSGGNLTSSVSevdKTKTSSPSSTAFTSSSGQTASSGGKSGDSFTTAPTTTLGLINVSSQPT 151
Cdd:COG3469   9 SPTAGGASATAVTLLGAAATAASVTLTAA---TATTVVSTTGSVVVAASGSAGSGTGTTAASSTAATSSTTSTTATATAA 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328219 152 DLNTTS---KLLSTPTTDNTTSPQQPVDSSPSTASHPVGQHTPAAVPSSSGSTPSTDNSTLTWKPTTHKPLGTSEATQPL 228
Cdd:COG3469  86 AAAATStsaTLVATSTASGANTGTSTVTTTSTGAGSVTSTTSSTAGSTTTSGASATSSAGSTTTTTTVSGTETATGGTTT 165

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|
gi 34328219 229 TSQTPGITTLPVSTlqqsmaSTVGTTTeefthlisNGTPVAPPGPSTPSP 278
Cdd:COG3469 166 TSTTTTTTSASTTP------SATTTAT--------ATTASGATTPSATTT 201
Chi1 COG3469
Chitinase [Carbohydrate transport and metabolism];
42-255 1.43e-06

Chitinase [Carbohydrate transport and metabolism];


Pssm-ID: 442692 [Multi-domain]  Cd Length: 534  Bit Score: 50.91  E-value: 1.43e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328219  42 SATTSTEVTTGHPVASTLASTQPSNPTPFTTSTQSPSMPTSTPNPTSNQSGGNLTSSVSEVDKTKTSSPSSTAFTSSSGQ 121
Cdd:COG3469   1 SSSVSTAASPTAGGASATAVTLLGAAATAASVTLTAATATTVVSTTGSVVVAASGSAGSGTGTTAASSTAATSSTTSTTA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328219 122 TASSggksgdSFTTAPTTTLGLINVSSQPTDLNTTSKLLSTPTTD-NTTSPQQPVDSSPSTASHPVGQHTPAAVPSSSGS 200
Cdd:COG3469  81 TATA------AAAAATSTSATLVATSTASGANTGTSTVTTTSTGAgSVTSTTSSTAGSTTTSGASATSSAGSTTTTTTVS 154

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*
gi 34328219 201 TPstdnSTLTWKPTTHKPLGTSEATQPLTSQTPGITTLPVSTLQQSMASTVGTTT 255
Cdd:COG3469 155 GT----ETATGGTTTTSTTTTTTSASTTPSATTTATATTASGATTPSATTTATTT 205
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 27-295 4.22e-05

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 46.45  E-value: 4.22e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328219    27 TSTSAIKSSTVQSHQSATTSTEVTTGHPVASTLASTQPSNPTPF-TTSTQSPSMPTSTPNPTSNQSGG-NLTSSVSEVDK 104
Cdd:pfam05109 436 TTGFAAPNTTTGLPSSTHVPTNLTAPASTGPTVSTADVTSPTPAgTTSGASPVTPSPSPRDNGTESKApDMTSPTSAVTT 515

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328219   105 TKTSSPSSTAFTSSSGQTASS---GGKSGDSFTTAPTTTlglinvSSQPTDLNTTSKLLSTPTTDNTTSPQQPVDS-SPS 180
Cdd:pfam05109 516 PTPNATSPTPAVTTPTPNATSptlGKTSPTSAVTTPTPN------ATSPTPAVTTPTPNATIPTLGKTSPTSAVTTpTPN 589

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328219   181 TASHPVGQHTPAAVPSSSGSTPSTDNSTLTwKPTTHKPLGTSEATQPLTSQTPGITTLPVSTLQQSMASTVGTTTEEFTH 260
Cdd:pfam05109 590 ATSPTVGETSPQANTTNHTLGGTSSTPVVT-SPPKNATSAVTTGQHNITSSSTSSMSLRPSSISETLSPSTSDNSTSHMP 668

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 34328219   261 LISNGTPVAPPGPSTPSPIWAFGNYQLNCEPPIRP 295
Cdd:pfam05109 669 LLTSAHPTGGENITQVTPASTSTHHVSTSSPAPRP 703
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 2-274 6.54e-05

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 45.68  E-value: 6.54e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328219     2 PPTTALSALLLLLLSPASHSHNGNETSTSAIKSSTVQSHQSATTSTEVTTGHPVASTLASTQPSNPTPF----------- 70
Cdd:pfam05109 425 PESTTTSPTLNTTGFAAPNTTTGLPSSTHVPTNLTAPASTGPTVSTADVTSPTPAGTTSGASPVTPSPSprdngteskap 504

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328219    71 --------------TTSTQSPSMPTSTPNPTSNQSGGNLTSSVSEVDKTKTSSPSSTAFTSSSGQTASSGGK-SGDSFTT 135
Cdd:pfam05109 505 dmtsptsavttptpNATSPTPAVTTPTPNATSPTLGKTSPTSAVTTPTPNATSPTPAVTTPTPNATIPTLGKtSPTSAVT 584

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328219   136 APTTTLGLINVSSQPTDLNTTSKLL-STPTTDNTTSPQQPVDSSPSTASHPVGQHTPAAVPSSSGSTPSTDNSTLTWKPT 214
Cdd:pfam05109 585 TPTPNATSPTVGETSPQANTTNHTLgGTSSTPVVTSPPKNATSAVTTGQHNITSSSTSSMSLRPSSISETLSPSTSDNST 664

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 34328219   215 THKPLGTS---EATQPLTSQTPGITTL-----------PVSTLQQSMASTVGTTTEEFTHLISNGTP----VAPPGPS 274
Cdd:pfam05109 665 SHMPLLTSahpTGGENITQVTPASTSThhvstsspaprPGTTSQASGPGNSSTSTKPGEVNVTKGTPpknaTSPQAPS 742
Chi1 COG3469
Chitinase [Carbohydrate transport and metabolism];
21-239 8.48e-05

Chitinase [Carbohydrate transport and metabolism];


Pssm-ID: 442692 [Multi-domain]  Cd Length: 534  Bit Score: 45.13  E-value: 8.48e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328219  21 SHNGNETSTSAIKSSTVQSHQSATTSTEVTTGHPVASTLASTQPSNPTpfTTSTQSPSMPTSTPNPTSNQSGGNLTSSVS 100
Cdd:COG3469  15 ASATAVTLLGAAATAASVTLTAATATTVVSTTGSVVVAASGSAGSGTG--TTAASSTAATSSTTSTTATATAAAAAATST 92

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328219 101 EVdKTKTSSPSSTAFTSSSGQTASSGGKSGDSFTTAPTTTLGLINVSSQPTDLNTTSKLLSTPTTDNTTSPqqpVDSSPS 180
Cdd:COG3469  93 SA-TLVATSTASGANTGTSTVTTTSTGAGSVTSTTSSTAGSTTTSGASATSSAGSTTTTTTVSGTETATGG---TTTTST 168

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 34328219 181 TASHPVGQHTPAAVPSSSgstpstdnstltwkPTTHKPLGTSEATQPLTSQTPGITTLP 239
Cdd:COG3469 169 TTTTTSASTTPSATTTAT--------------ATTASGATTPSATTTATTTGPPTPGLP 213
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 46-278 1.39e-04

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 44.57  E-value: 1.39e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328219    46 STEVTTGHP--------------VASTLASTQPSNPTPFTTSTQSPSMPTSTPNPTSNQsggnLTSSVSEVDKTKTSSPS 111
Cdd:pfam17823  83 STEVTAEHTphgtdlsepatregAADGAASRALAAAASSSPSSAAQSLPAAIAALPSEA----FSAPRAAACRANASAAP 158

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328219   112 STAF-TSSSGQTASSGGKSGDSFTTAPTTTLGlinVSSQPTDLNTTSKLLSTPTTDNTTSPQQPVDSSPSTASHPVGQHT 190
Cdd:pfam17823 159 RAAIaAASAPHAASPAPRTAASSTTAASSTTA---ASSAPTTAASSAPATLTPARGISTAATATGHPAAGTALAAVGNSS 235

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328219   191 PAAVPSSSGSTPSTDNSTLTWKP---TTHKPLGTSEATQPLTSQTPGITTLPVSTLQQSMASTVGTTTEEFTHLISNGTP 267
Cdd:pfam17823 236 PAAGTVTAAVGTVTPAALATLAAaagTVASAAGTINMGDPHARRLSPAKHMPSDTMARNPAAPMGAQAQGPIIQVSTDQP 315

                         250
                  ....*....|..
gi 34328219   268 VAPPGPS-TPSP 278
Cdd:pfam17823 316 VHNTAGEpTPSP 327
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 27-276 2.18e-04

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 43.80  E-value: 2.18e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328219    27 TSTSAIKSSTVQSHQSATTSTEVTTGHPVASTLASTQPSNPTPFTTSTQSPSMPTSTPNPTSNQSGGNLTSSVSEVDKTK 106
Cdd:pfam17823 128 QSLPAAIAALPSEAFSAPRAAACRANASAAPRAAIAAASAPHAASPAPRTAASSTTAASSTTAASSAPTTAASSAPATLT 207

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328219   107 TSSPSSTAFTSSSGQTASSGGKSGDSFTTAPTTTLGLINVSSQPTDLNTTSKLLSTPTTDNTTSPQQPVDSSPSTAshpv 186
Cdd:pfam17823 208 PARGISTAATATGHPAAGTALAAVGNSSPAAGTVTAAVGTVTPAALATLAAAAGTVASAAGTINMGDPHARRLSPA---- 283

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328219   187 gQHTPAavpsssgsTPSTDNSTLTWKPTTHKPLGTSEATQPLTSQTPGITTLPVSTLQQ--------SMASTVGTTTEEF 258
Cdd:pfam17823 284 -KHMPS--------DTMARNPAAPMGAQAQGPIIQVSTDQPVHNTAGEPTPSPSNTTLEpntpksvaSTNLAVVTTTKAQ 354

                         250
                  ....*....|....*...
gi 34328219   259 THLISNGTPVAPPGPSTP 276
Cdd:pfam17823 355 AKEPSASPVPVLHTSMIP 372
PHA03247 PHA03247
large tegument protein UL36; Provisional
 54-278 3.18e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.77  E-value: 3.18e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328219    54 PVASTLASTQPSNPTPFTTSTQSPSMPTSTPNPTSNQSGGNLTSSVSEVDKTKTSSPSSTAftSSSGQTASSGGKSGDSF 133
Cdd:PHA03247 2601 PVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRV--SRPRRARRLGRAAQASS 2678

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328219   134 TT------APTTTLGLINVSSQPTDLNTTSKLLSTPTTDNTTSPQQPVDSSPSTASHPVGQHTPAAVPSSSGSTPSTDNS 207
Cdd:PHA03247 2679 PPqrprrrAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPA 2758

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328219   208 TltwKPTTHKPLGTSEATQPLTSQTPGITTLPVSTLQQSMAS------------TVGTTTEEFTHLISNGTPVAPPGPST 275
Cdd:PHA03247 2759 R---PPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESlpspwdpadppaAVLAPAAALPPAASPAGPLPPPTSAQ 2835


                  ...
gi 34328219   276 PSP 278
Cdd:PHA03247 2836 PTA 2838
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 38-253 4.60e-04

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 42.98  E-value: 4.60e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328219    38 QSHQSATTSTEVTTGHPVASTLASTQPSNPTPFTTSTQSPSMPTSTPNPTSNQSGGNLTSSVSEVDKTKTSSPSSTafTS 117
Cdd:pfam05109 407 RTATNATTTTHKVIFSKAPESTTTSPTLNTTGFAAPNTTTGLPSSTHVPTNLTAPASTGPTVSTADVTSPTPAGTT--SG 484

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328219   118 SSGQTASSGGKSGDSFTTAPTTTLGLINVSSQPTDLNTTSKLLSTPTTdNTTSPQQPVDSSPSTASHPvgqhTPAAVPSS 197
Cdd:pfam05109 485 ASPVTPSPSPRDNGTESKAPDMTSPTSAVTTPTPNATSPTPAVTTPTP-NATSPTLGKTSPTSAVTTP----TPNATSPT 559

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 34328219   198 SGSTPSTDNSTLtwkPTTHKPLGTSEATQPL---TSQTPGITTLPVSTLQQSMASTVGT 253
Cdd:pfam05109 560 PAVTTPTPNATI---PTLGKTSPTSAVTTPTpnaTSPTVGETSPQANTTNHTLGGTSST 615
Chi1 COG3469
Chitinase [Carbohydrate transport and metabolism];
27-149 4.71e-04

Chitinase [Carbohydrate transport and metabolism];


Pssm-ID: 442692 [Multi-domain]  Cd Length: 534  Bit Score: 42.82  E-value: 4.71e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328219  27 TSTSAIKSSTVQSHQSATTSTEVTTGHPVASTLASTQPSNPTPFTTSTQSPSMPTSTPNPTS---------------NQS 91
Cdd:COG3469  78 TTATATAAAAAATSTSATLVATSTASGANTGTSTVTTTSTGAGSVTSTTSSTAGSTTTSGASatssagsttttttvsGTE 157

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 34328219  92 GGNLTSSVSEVDKTKTSSPSSTAFTSSSGQTASSGGKSGDSFTTAPTTTLGLINVSSQ 149
Cdd:COG3469 158 TATGGTTTTSTTTTTTSASTTPSATTTATATTASGATTPSATTTATTTGPPTPGLPKH 215
ser_rich_anae_1 NF033849
serine-rich protein; This serine-rich protein belongs to a family with large size (over 1000 ...
 41-187 6.83e-04

serine-rich protein; This serine-rich protein belongs to a family with large size (over 1000 amino acids), which a highly serine-rich central region that averages over 300 aa in length. Species encoding members of this family of proteins tend to be anaerobic bacteria, including Gram-positive bacteria of the human gut microbiome and Chloroflexi from marine sediments.


Pssm-ID: 468206 [Multi-domain]  Cd Length: 1122  Bit Score: 42.30  E-value: 6.83e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328219    41 QSATTSTEVTTGHPVASTLAST--QPSNPTPFTTSTQSPSMPTSTPNPTSNQSGGNLTSSVSEVDKTKTSSPSSTAFTSS 118
Cdd:NF033849  237 QSAGTGYGESVGHSTSQGQSHSvgTSESHSVGTSQSQSHTTGHGSTRGWSHTQSTSESESTGQSSSVGTSESQSHGTTEG 316

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 34328219   119 SGQTASSGGKSGDSFTTAPTTtlgliNVSSQPTDLNTTSKLLSTPTTDNTTSPQQPVDSSPSTASHPVG 187
Cdd:NF033849  317 TSTTDSSSHSQSSSYNVSSGT-----GVSSSHSDGTSQSTSISHSESSSESTGTSVGHSTSSSVSSSES 380
PHA03247 PHA03247
large tegument protein UL36; Provisional
 54-299 2.47e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.69  E-value: 2.47e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328219    54 PVASTLASTQPSNPTPFTTSTQSPSMPtSTPNPTSNQSGGNL--------------TSSVSEVDKTKTSSPSSTAFTSSS 119
Cdd:PHA03247 2691 TVGSLTSLADPPPPPPTPEPAPHALVS-ATPLPPGPAAARQAspalpaapappavpAGPATPGGPARPARPPTTAGPPAP 2769

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328219   120 GQTASSGGKSGDSFTTAPTTTLGL-INVSSQPTDLNTTSKLLSTPTTDNTTSPQQPVDSSPSTASHPVGQHTPAAvpsSS 198
Cdd:PHA03247 2770 APPAAPAAGPPRRLTRPAVASLSEsRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPG---PP 2846

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328219   199 GSTPSTDNSTLTWKPTTHKPLGTSEATQPLTSQTPGITTLPVSTLQQSmastvgttTEEFT----HLISNGTPVAPPGPS 274
Cdd:PHA03247 2847 PPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRS--------TESFAlppdQPERPPQPQAPPPPQ 2918

                         250       260
                  ....*....|....*....|....*
gi 34328219   275 TPSPIWAFGNYQLNCEPPIRPDEEL 299
Cdd:PHA03247 2919 PQPQPPPPPQPQPPPPPPPRPQPPL 2943
PRK08581 PRK08581
amidase domain-containing protein;
21-185 2.50e-03

amidase domain-containing protein;


Pssm-ID: 236304 [Multi-domain]  Cd Length: 619  Bit Score: 40.54  E-value: 2.50e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328219   21 SHNGNETSTSAIKSSTVQShqsaTTSTEVTTGHPVASTLAST---QPSNPTPFTTSTQSPSMPTSTPNPTSNQSGGNLTS 97
Cdd:PRK08581  65 NNNTSNQDNNDKKFSTIDS----STSDSNNIIDFIYKNLPQTninQLLTKNKYDDNYSLTTLIQNLFNLNSDISDYEQPR 140

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328219   98 SVSEVDKTKTSSPSSTAFTSSSGQTASSGGKSGDSFTTAPTTTLGLINVSSQPTDLNTTSKLLSTPTTDNTTspQQPVDS 177
Cdd:PRK08581 141 NSEKSTNDSNKNSDSSIKNDTDTQSSKQDKADNQKAPSSNNTKPSTSNKQPNSPKPTQPNQSNSQPASDDTA--NQKSSS 218


                 ....*...
gi 34328219  178 SPSTASHP 185
Cdd:PRK08581 219 KDNQSMSD 226
ser_rich_anae_1 NF033849
serine-rich protein; This serine-rich protein belongs to a family with large size (over 1000 ...
 35-142 9.73e-03

serine-rich protein; This serine-rich protein belongs to a family with large size (over 1000 amino acids), which a highly serine-rich central region that averages over 300 aa in length. Species encoding members of this family of proteins tend to be anaerobic bacteria, including Gram-positive bacteria of the human gut microbiome and Chloroflexi from marine sediments.


Pssm-ID: 468206 [Multi-domain]  Cd Length: 1122  Bit Score: 38.83  E-value: 9.73e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 34328219    35 STVQSH---QSATTSTEVTTGHPVASTLASTQPSNPTPFTTSTQSPSMPTSTPNPTSNQSGGNLTSSVSEVDKTKTSSPS 111
Cdd:NF033849  252 SQGQSHsvgTSESHSVGTSQSQSHTTGHGSTRGWSHTQSTSESESTGQSSSVGTSESQSHGTTEGTSTTDSSSHSQSSSY 331

                          90       100       110
                  ....*....|....*....|....*....|.
gi 34328219   112 STAFTSSSGQTASSGGKSGDSFTTAPTTTLG 142
Cdd:NF033849  332 NVSSGTGVSSSHSDGTSQSTSISHSESSSES 362
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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