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Conserved domains on  [gi|160708008|ref|NP_038594|]
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integrin beta-7 precursor [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
INB smart00187
Integrin beta subunits (N-terminal portion of extracellular region); Portion of beta integrins ...
 50-476 0e+00

Integrin beta subunits (N-terminal portion of extracellular region); Portion of beta integrins that lies N-terminal to their EGF-like repeats. Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Beta integrins are proposed to have a von Willebrand factor type-A "insert" or "I" -like domain (although this remains to be confirmed).


:

Pssm-ID: 197563 [Multi-domain]  Cd Length: 423  Bit Score: 677.89  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160708008    50 SCQKCILSHPSCAWCKQLNFTASGeaeARRCARREELLARGCPAQELEEPRGRQEVLQDKPLSQGDRGEGATQLAPQRIR 129
Cdd:smart00187   1 SCEECIQSGPNCAWCTDENFTSGG---SARCDTRANLLAKGCSPESIENPASSAEVLEDKPLSDKGSGGQAVQVSPQRVR 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160708008   130 VTLRPGEPQKFRVRFLRAAGYPVDLYYLMDLSYSMKDDLERVRQLGHALLVRLQEVTHSVRIGFGSFVDKTVLPFVSTVP 209
Cdd:smart00187  78 LKLRPGEPQNFTLTVRQAEDYPVDLYYLMDLSYSMKDDLDNLKSLGDDLAREMKGLTSNFRLGFGSFVDKTVSPFVSTHP 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160708008   210 SKLHHPCPSRLERCQPPFSFHHVLSLTGDAQAFEREVGRQNVSGNLDSPEGGFDAILQAALCQEQIGWRNVSR-LLVFTS 288
Cdd:smart00187 158 EKLENPCPNYNKTCEPPYGFKHVLSLTDDTDEFNEEVGKQRISGNLDAPEGGFDAIMQAAVCTEQIGWREDARrLLVFST 237

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160708008   289 DDTFHTAGDGKLGGIFMPSDGRCHLDSNGVYTNSAEFDYPSVGQVAQALTAANIQPIFAVTGATLPVYQELRQLIPKSAV 368
Cdd:smart00187 238 DAGFHFAGDGKLGGIVTPNDGQCHLDNNGEYTMSTTQDYPSIGQLAQKLAENNINPIFAVTKKQVSLYKELSALIPGSSV 317

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160708008   369 GELSEDSSNVVQLIMDAYDSLSSTVTLEHSPLPPGVSISFESHCKGPEKTEGEAGdrgqCNDVRVNQTVDFWVTLQATHC 448
Cdd:smart00187 318 GELSEDSSNVVELIKDAYNKISSRVELEDNALPEGVSVTYTSSCPGGVTGPGTRK----CEGVKIGDTVSFEVTVTATKC 393

                          410       420       430
                   ....*....|....*....|....*....|
gi 160708008   449 LPE--AHVLRLWALGFSEELTVELHTVCDC 476
Cdd:smart00187 394 PPEdqEQSIRIRPVGFSETLEVEVTFLCDC 423
Integrin_b_cyt pfam08725
Integrin beta cytoplasmic domain; Integrins are a group of transmembrane proteins which ...
 749-789 9.20e-20

Integrin beta cytoplasmic domain; Integrins are a group of transmembrane proteins which function as extracellular matrix receptors and in cell adhesion. Integrins are ubiquitously expressed and are heterodimeric, each composed of an alpha and beta subunit. Several variations of the the alpha and beta subunits exist, and association of different alpha and beta subunits can have different a different binding specificity. This domain corresponds to the cytoplasmic domain of the beta subunit.


:

Pssm-ID: 462580  Cd Length: 41  Bit Score: 82.99  E-value: 9.20e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 160708008  749 VEIYDRREYRRFEKEQQQLNWKQDNNPLYKSAITTTVNPRF 789
Cdd:pfam08725   1 TTIHDRREYAKFEKERKNAKWTTGENPLYKSATTTFENPTY 41
Integrin_B_tail super family cl06832
Integrin beta tail domain; This is the beta tail domain of the Integrin protein. Integrins are ...
 645-716 6.98e-06

Integrin beta tail domain; This is the beta tail domain of the Integrin protein. Integrins are receptors which are involved in cell-cell and cell-extracellular matrix interactions.


The actual alignment was detected with superfamily member pfam07965:

Pssm-ID: 462325  Cd Length: 84  Bit Score: 44.96  E-value: 6.98e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 160708008  645 CEQYRDCAECGAFGTGPL-AANCSVVCAD-VNVTLTLAPNLDDGW--CKERTIDNQLFFFLVEHAASG-IVLRVRPQ 716
Cdd:pfam07965   1 CEEKKSCVECQAFKTGPLkEKNCSRNCKFeIILVEVLKEDEEPGAvlCSFKDEDDCWFTFTYYEDESGkYVVHVQKE 77
I-EGF_1 pfam18372
Integrin beta epidermal growth factor like domain 1; This is the I-EGF 1 domain found in ...
 476-506 2.02e-03

Integrin beta epidermal growth factor like domain 1; This is the I-EGF 1 domain found in several integrin betas such as integrin beta 1-7. Structural analysis reveal an epidermal growth factor-like (I-EGF) domains 1 and 2. EGF1 lacks one disulfide (C2-C4) relative to the integrin EGF 2, 3, and 4 domains, this allows the C-terminal end of EGF1 to flex remarkably relative to its N-terminal end.


:

Pssm-ID: 465729  Cd Length: 29  Bit Score: 36.31  E-value: 2.02e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 160708008  476 CNCgDAQPHAPYCSdGQGDLQCGICSCAPGR 506
Cdd:pfam18372   1 CEK-QAEPNSPRCS-GNGTFVCGVCVCNPGY 29
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 612-635 8.11e-03

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


:

Pssm-ID: 400365  Cd Length: 26  Bit Score: 34.63  E-value: 8.11e-03
                          10        20
                  ....*....|....*....|....*.
gi 160708008  612 LCSGHGYC--KCNRCQCLDGYYGALC 635
Cdd:pfam07974   1 ICSGRGTCvnQCGKCVCDSGYQGATC 26
 
Name Accession Description Interval E-value
INB smart00187
Integrin beta subunits (N-terminal portion of extracellular region); Portion of beta integrins ...
 50-476 0e+00

Integrin beta subunits (N-terminal portion of extracellular region); Portion of beta integrins that lies N-terminal to their EGF-like repeats. Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Beta integrins are proposed to have a von Willebrand factor type-A "insert" or "I" -like domain (although this remains to be confirmed).


Pssm-ID: 197563 [Multi-domain]  Cd Length: 423  Bit Score: 677.89  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160708008    50 SCQKCILSHPSCAWCKQLNFTASGeaeARRCARREELLARGCPAQELEEPRGRQEVLQDKPLSQGDRGEGATQLAPQRIR 129
Cdd:smart00187   1 SCEECIQSGPNCAWCTDENFTSGG---SARCDTRANLLAKGCSPESIENPASSAEVLEDKPLSDKGSGGQAVQVSPQRVR 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160708008   130 VTLRPGEPQKFRVRFLRAAGYPVDLYYLMDLSYSMKDDLERVRQLGHALLVRLQEVTHSVRIGFGSFVDKTVLPFVSTVP 209
Cdd:smart00187  78 LKLRPGEPQNFTLTVRQAEDYPVDLYYLMDLSYSMKDDLDNLKSLGDDLAREMKGLTSNFRLGFGSFVDKTVSPFVSTHP 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160708008   210 SKLHHPCPSRLERCQPPFSFHHVLSLTGDAQAFEREVGRQNVSGNLDSPEGGFDAILQAALCQEQIGWRNVSR-LLVFTS 288
Cdd:smart00187 158 EKLENPCPNYNKTCEPPYGFKHVLSLTDDTDEFNEEVGKQRISGNLDAPEGGFDAIMQAAVCTEQIGWREDARrLLVFST 237

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160708008   289 DDTFHTAGDGKLGGIFMPSDGRCHLDSNGVYTNSAEFDYPSVGQVAQALTAANIQPIFAVTGATLPVYQELRQLIPKSAV 368
Cdd:smart00187 238 DAGFHFAGDGKLGGIVTPNDGQCHLDNNGEYTMSTTQDYPSIGQLAQKLAENNINPIFAVTKKQVSLYKELSALIPGSSV 317

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160708008   369 GELSEDSSNVVQLIMDAYDSLSSTVTLEHSPLPPGVSISFESHCKGPEKTEGEAGdrgqCNDVRVNQTVDFWVTLQATHC 448
Cdd:smart00187 318 GELSEDSSNVVELIKDAYNKISSRVELEDNALPEGVSVTYTSSCPGGVTGPGTRK----CEGVKIGDTVSFEVTVTATKC 393

                          410       420       430
                   ....*....|....*....|....*....|
gi 160708008   449 LPE--AHVLRLWALGFSEELTVELHTVCDC 476
Cdd:smart00187 394 PPEdqEQSIRIRPVGFSETLEVEVTFLCDC 423
Integrin_beta pfam00362
Integrin beta chain VWA domain; Integrins have been found in animals and their homologs have ...
 147-393 1.44e-157

Integrin beta chain VWA domain; Integrins have been found in animals and their homologs have also been found in cyanobacteria, probably due to horizontal gene transfer. This domain corresponds to the integrin beta VWA domain.


Pssm-ID: 459781  Cd Length: 248  Bit Score: 458.50  E-value: 1.44e-157
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160708008  147 AAGYPVDLYYLMDLSYSMKDDLERVRQLGHALLVRLQEVTHSVRIGFGSFVDKTVLPFVSTVPSKLHHPCPSRLERCQPP 226
Cdd:pfam00362   1 AEDYPVDLYYLMDLSYSMKDDLDNLKKLGNDLAEEMRNITSNFRLGFGSFVDKPVMPYISTRPEKLKNPCPGENEQCDPP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160708008  227 FSFHHVLSLTGDAQAFEREVGRQNVSGNLDSPEGGFDAILQAALCQEQIGWRN-VSRLLVFTSDDTFHTAGDGKLGGIFM 305
Cdd:pfam00362  81 FGFRHVLSLTNDIEEFTEEVQKQRISGNLDAPEGGFDAIMQAAVCKDQIGWRNeARRLLVFSTDAGFHYAGDGKLAGIVT 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160708008  306 PSDGRCHLDSNGVYTNSAEFDYPSVGQVAQALTAANIQPIFAVTGATLPVYQELRQLIPKSAVGELSEDSSNVVQLIMDA 385
Cdd:pfam00362 161 PNDGQCHLDSNGEYTKSTEQDYPSLGQLVRKLSENNINPIFAVTEEQYSLYEKLSKLIPGSSVGVLSEDSSNIVQLIKEA 240


                  ....*...
gi 160708008  386 YDSLSSTV 393
Cdd:pfam00362 241 YEKIRSKV 248
Integrin_b_cyt pfam08725
Integrin beta cytoplasmic domain; Integrins are a group of transmembrane proteins which ...
 749-789 9.20e-20

Integrin beta cytoplasmic domain; Integrins are a group of transmembrane proteins which function as extracellular matrix receptors and in cell adhesion. Integrins are ubiquitously expressed and are heterodimeric, each composed of an alpha and beta subunit. Several variations of the the alpha and beta subunits exist, and association of different alpha and beta subunits can have different a different binding specificity. This domain corresponds to the cytoplasmic domain of the beta subunit.


Pssm-ID: 462580  Cd Length: 41  Bit Score: 82.99  E-value: 9.20e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 160708008  749 VEIYDRREYRRFEKEQQQLNWKQDNNPLYKSAITTTVNPRF 789
Cdd:pfam08725   1 TTIHDRREYAKFEKERKNAKWTTGENPLYKSATTTFENPTY 41
Integrin_B_tail pfam07965
Integrin beta tail domain; This is the beta tail domain of the Integrin protein. Integrins are ...
 645-716 6.98e-06

Integrin beta tail domain; This is the beta tail domain of the Integrin protein. Integrins are receptors which are involved in cell-cell and cell-extracellular matrix interactions.


Pssm-ID: 462325  Cd Length: 84  Bit Score: 44.96  E-value: 6.98e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 160708008  645 CEQYRDCAECGAFGTGPL-AANCSVVCAD-VNVTLTLAPNLDDGW--CKERTIDNQLFFFLVEHAASG-IVLRVRPQ 716
Cdd:pfam07965   1 CEEKKSCVECQAFKTGPLkEKNCSRNCKFeIILVEVLKEDEEPGAvlCSFKDEDDCWFTFTYYEDESGkYVVHVQKE 77
I-EGF_1 pfam18372
Integrin beta epidermal growth factor like domain 1; This is the I-EGF 1 domain found in ...
 476-506 2.02e-03

Integrin beta epidermal growth factor like domain 1; This is the I-EGF 1 domain found in several integrin betas such as integrin beta 1-7. Structural analysis reveal an epidermal growth factor-like (I-EGF) domains 1 and 2. EGF1 lacks one disulfide (C2-C4) relative to the integrin EGF 2, 3, and 4 domains, this allows the C-terminal end of EGF1 to flex remarkably relative to its N-terminal end.


Pssm-ID: 465729  Cd Length: 29  Bit Score: 36.31  E-value: 2.02e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 160708008  476 CNCgDAQPHAPYCSdGQGDLQCGICSCAPGR 506
Cdd:pfam18372   1 CEK-QAEPNSPRCS-GNGTFVCGVCVCNPGY 29
oat TIGR00805
sodium-independent organic anion transporter; The Organo Anion Transporter (OAT) Family (TC 2. ...
 598-718 3.85e-03

sodium-independent organic anion transporter; The Organo Anion Transporter (OAT) Family (TC 2.A.60)Proteins of the OAT family catalyze the Na+-independent facilitated transport of organic anions such as bromosulfobromophthalein and prostaglandins as well as conjugated and unconjugated bile acids (taurocholate and cholate, respectively). These transporters have been characterized in mammals, but homologues are present in C. elegans and A. thaliana. Some of the mammalian proteins exhibit a high degree of tissue specificity. For example, the rat OAT is found at high levels in liver and kidney and at lower levels in other tissues. These proteins possess 10-12 putative a-helical transmembrane spanners. They may catalyze electrogenic anion uniport or anion exchange.


Pssm-ID: 273279 [Multi-domain]  Cd Length: 632  Bit Score: 40.87  E-value: 3.85e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160708008  598 CSKSVDSCVSPEGGLCSGHGYCK--CNR-CQCLDGYYGALCDQC-LGCKSPCeqYRDCAECGAFGTGPLAANCSVVCADV 673
Cdd:TIGR00805 423 CESAPVAGVNNPSNDQPLYVENRtdCNRqCSCDSSIWDPVCGDNgLAYLSPC--HAGCRMSVGTGSNMVFTNCSCIQTPG 500

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 160708008  674 NVTLTLapnlddGWCKErTIDNQLFFFLVEHAASG------------IVLRVRPQEK 718
Cdd:TIGR00805 501 NSSAKK------GLCDP-PCATSLQYFLILFIPLSfiyfitavpgymVLLRCVKSEE 550
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 612-635 8.11e-03

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 34.63  E-value: 8.11e-03
                          10        20
                  ....*....|....*....|....*.
gi 160708008  612 LCSGHGYC--KCNRCQCLDGYYGALC 635
Cdd:pfam07974   1 ICSGRGTCvnQCGKCVCDSGYQGATC 26
 
Name Accession Description Interval E-value
INB smart00187
Integrin beta subunits (N-terminal portion of extracellular region); Portion of beta integrins ...
 50-476 0e+00

Integrin beta subunits (N-terminal portion of extracellular region); Portion of beta integrins that lies N-terminal to their EGF-like repeats. Integrins are cell adhesion molecules that mediate cell-extracellular matrix and cell-cell interactions. They contain both alpha and beta subunits. Beta integrins are proposed to have a von Willebrand factor type-A "insert" or "I" -like domain (although this remains to be confirmed).


Pssm-ID: 197563 [Multi-domain]  Cd Length: 423  Bit Score: 677.89  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160708008    50 SCQKCILSHPSCAWCKQLNFTASGeaeARRCARREELLARGCPAQELEEPRGRQEVLQDKPLSQGDRGEGATQLAPQRIR 129
Cdd:smart00187   1 SCEECIQSGPNCAWCTDENFTSGG---SARCDTRANLLAKGCSPESIENPASSAEVLEDKPLSDKGSGGQAVQVSPQRVR 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160708008   130 VTLRPGEPQKFRVRFLRAAGYPVDLYYLMDLSYSMKDDLERVRQLGHALLVRLQEVTHSVRIGFGSFVDKTVLPFVSTVP 209
Cdd:smart00187  78 LKLRPGEPQNFTLTVRQAEDYPVDLYYLMDLSYSMKDDLDNLKSLGDDLAREMKGLTSNFRLGFGSFVDKTVSPFVSTHP 157

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160708008   210 SKLHHPCPSRLERCQPPFSFHHVLSLTGDAQAFEREVGRQNVSGNLDSPEGGFDAILQAALCQEQIGWRNVSR-LLVFTS 288
Cdd:smart00187 158 EKLENPCPNYNKTCEPPYGFKHVLSLTDDTDEFNEEVGKQRISGNLDAPEGGFDAIMQAAVCTEQIGWREDARrLLVFST 237

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160708008   289 DDTFHTAGDGKLGGIFMPSDGRCHLDSNGVYTNSAEFDYPSVGQVAQALTAANIQPIFAVTGATLPVYQELRQLIPKSAV 368
Cdd:smart00187 238 DAGFHFAGDGKLGGIVTPNDGQCHLDNNGEYTMSTTQDYPSIGQLAQKLAENNINPIFAVTKKQVSLYKELSALIPGSSV 317

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160708008   369 GELSEDSSNVVQLIMDAYDSLSSTVTLEHSPLPPGVSISFESHCKGPEKTEGEAGdrgqCNDVRVNQTVDFWVTLQATHC 448
Cdd:smart00187 318 GELSEDSSNVVELIKDAYNKISSRVELEDNALPEGVSVTYTSSCPGGVTGPGTRK----CEGVKIGDTVSFEVTVTATKC 393

                          410       420       430
                   ....*....|....*....|....*....|
gi 160708008   449 LPE--AHVLRLWALGFSEELTVELHTVCDC 476
Cdd:smart00187 394 PPEdqEQSIRIRPVGFSETLEVEVTFLCDC 423
Integrin_beta pfam00362
Integrin beta chain VWA domain; Integrins have been found in animals and their homologs have ...
 147-393 1.44e-157

Integrin beta chain VWA domain; Integrins have been found in animals and their homologs have also been found in cyanobacteria, probably due to horizontal gene transfer. This domain corresponds to the integrin beta VWA domain.


Pssm-ID: 459781  Cd Length: 248  Bit Score: 458.50  E-value: 1.44e-157
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160708008  147 AAGYPVDLYYLMDLSYSMKDDLERVRQLGHALLVRLQEVTHSVRIGFGSFVDKTVLPFVSTVPSKLHHPCPSRLERCQPP 226
Cdd:pfam00362   1 AEDYPVDLYYLMDLSYSMKDDLDNLKKLGNDLAEEMRNITSNFRLGFGSFVDKPVMPYISTRPEKLKNPCPGENEQCDPP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160708008  227 FSFHHVLSLTGDAQAFEREVGRQNVSGNLDSPEGGFDAILQAALCQEQIGWRN-VSRLLVFTSDDTFHTAGDGKLGGIFM 305
Cdd:pfam00362  81 FGFRHVLSLTNDIEEFTEEVQKQRISGNLDAPEGGFDAIMQAAVCKDQIGWRNeARRLLVFSTDAGFHYAGDGKLAGIVT 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160708008  306 PSDGRCHLDSNGVYTNSAEFDYPSVGQVAQALTAANIQPIFAVTGATLPVYQELRQLIPKSAVGELSEDSSNVVQLIMDA 385
Cdd:pfam00362 161 PNDGQCHLDSNGEYTKSTEQDYPSLGQLVRKLSENNINPIFAVTEEQYSLYEKLSKLIPGSSVGVLSEDSSNIVQLIKEA 240


                  ....*...
gi 160708008  386 YDSLSSTV 393
Cdd:pfam00362 241 YEKIRSKV 248
Integrin_b_cyt pfam08725
Integrin beta cytoplasmic domain; Integrins are a group of transmembrane proteins which ...
 749-789 9.20e-20

Integrin beta cytoplasmic domain; Integrins are a group of transmembrane proteins which function as extracellular matrix receptors and in cell adhesion. Integrins are ubiquitously expressed and are heterodimeric, each composed of an alpha and beta subunit. Several variations of the the alpha and beta subunits exist, and association of different alpha and beta subunits can have different a different binding specificity. This domain corresponds to the cytoplasmic domain of the beta subunit.


Pssm-ID: 462580  Cd Length: 41  Bit Score: 82.99  E-value: 9.20e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 160708008  749 VEIYDRREYRRFEKEQQQLNWKQDNNPLYKSAITTTVNPRF 789
Cdd:pfam08725   1 TTIHDRREYAKFEKERKNAKWTTGENPLYKSATTTFENPTY 41
PSI_integrin pfam17205
Integrin plexin domain; This short disulphide rich domain is found at the N-terminus of ...
 49-92 8.90e-10

Integrin plexin domain; This short disulphide rich domain is found at the N-terminus of integrin beta chains.


Pssm-ID: 465380  Cd Length: 47  Bit Score: 54.86  E-value: 8.90e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 160708008   49 PSCQKCILSHPSCAWCKQLNFTASGEaearRCARREELLARGCP 92
Cdd:pfam17205   8 TSCEECIQSGPDCAWCTDENFTSGSP----RCDTRENLLARGCS 47
Integrin_B_tail pfam07965
Integrin beta tail domain; This is the beta tail domain of the Integrin protein. Integrins are ...
 645-716 6.98e-06

Integrin beta tail domain; This is the beta tail domain of the Integrin protein. Integrins are receptors which are involved in cell-cell and cell-extracellular matrix interactions.


Pssm-ID: 462325  Cd Length: 84  Bit Score: 44.96  E-value: 6.98e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 160708008  645 CEQYRDCAECGAFGTGPL-AANCSVVCAD-VNVTLTLAPNLDDGW--CKERTIDNQLFFFLVEHAASG-IVLRVRPQ 716
Cdd:pfam07965   1 CEEKKSCVECQAFKTGPLkEKNCSRNCKFeIILVEVLKEDEEPGAvlCSFKDEDDCWFTFTYYEDESGkYVVHVQKE 77
I-EGF_1 pfam18372
Integrin beta epidermal growth factor like domain 1; This is the I-EGF 1 domain found in ...
 476-506 2.02e-03

Integrin beta epidermal growth factor like domain 1; This is the I-EGF 1 domain found in several integrin betas such as integrin beta 1-7. Structural analysis reveal an epidermal growth factor-like (I-EGF) domains 1 and 2. EGF1 lacks one disulfide (C2-C4) relative to the integrin EGF 2, 3, and 4 domains, this allows the C-terminal end of EGF1 to flex remarkably relative to its N-terminal end.


Pssm-ID: 465729  Cd Length: 29  Bit Score: 36.31  E-value: 2.02e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 160708008  476 CNCgDAQPHAPYCSdGQGDLQCGICSCAPGR 506
Cdd:pfam18372   1 CEK-QAEPNSPRCS-GNGTFVCGVCVCNPGY 29
oat TIGR00805
sodium-independent organic anion transporter; The Organo Anion Transporter (OAT) Family (TC 2. ...
 598-718 3.85e-03

sodium-independent organic anion transporter; The Organo Anion Transporter (OAT) Family (TC 2.A.60)Proteins of the OAT family catalyze the Na+-independent facilitated transport of organic anions such as bromosulfobromophthalein and prostaglandins as well as conjugated and unconjugated bile acids (taurocholate and cholate, respectively). These transporters have been characterized in mammals, but homologues are present in C. elegans and A. thaliana. Some of the mammalian proteins exhibit a high degree of tissue specificity. For example, the rat OAT is found at high levels in liver and kidney and at lower levels in other tissues. These proteins possess 10-12 putative a-helical transmembrane spanners. They may catalyze electrogenic anion uniport or anion exchange.


Pssm-ID: 273279 [Multi-domain]  Cd Length: 632  Bit Score: 40.87  E-value: 3.85e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 160708008  598 CSKSVDSCVSPEGGLCSGHGYCK--CNR-CQCLDGYYGALCDQC-LGCKSPCeqYRDCAECGAFGTGPLAANCSVVCADV 673
Cdd:TIGR00805 423 CESAPVAGVNNPSNDQPLYVENRtdCNRqCSCDSSIWDPVCGDNgLAYLSPC--HAGCRMSVGTGSNMVFTNCSCIQTPG 500

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 160708008  674 NVTLTLapnlddGWCKErTIDNQLFFFLVEHAASG------------IVLRVRPQEK 718
Cdd:TIGR00805 501 NSSAKK------GLCDP-PCATSLQYFLILFIPLSfiyfitavpgymVLLRCVKSEE 550
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 612-635 8.11e-03

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 34.63  E-value: 8.11e-03
                          10        20
                  ....*....|....*....|....*.
gi 160708008  612 LCSGHGYC--KCNRCQCLDGYYGALC 635
Cdd:pfam07974   1 ICSGRGTCvnQCGKCVCDSGYQGATC 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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