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Conserved domains on  [gi|7305303|ref|NP_038464|]
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nck-associated protein 1 isoform 1 [Homo sapiens]

Protein Classification

HEM-1/HEM-2 family protein( domain architecture ID 10560843)

HEM-1/HEM-2 family protein similar to human membrane-associated protein HEM-1 (NCKAP1L) and HEM-2 (NCKAP1/NAP1) which are components of the actin regulatory WAVE [WASP (Wiskott-Aldrich syndrome protein)-family verprolin homologous protein] complex

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
Nckap1 pfam09735
Nck-associated protein 1; Nck-associated protein 1 is part of lamellipodial complex that ...
13-1122 0e+00

Nck-associated protein 1; Nck-associated protein 1 is part of lamellipodial complex that controls Rac-dependent actin remodeling. It associates preferentially with the first SH3 domain of Nck and is a component of the WAVE2 complex composed of ABI1, CYFIP1/SRA1, NCKAP1/NAP1 and WASF2/WAVE2. It is also a component of the WAVE1 complex composed of ABI2, CYFIP2, C3orf10/HSPC300, NCKAP1 and WASF1/WAVE1. CYFIP2 binds to activated RAC1 which causes the complex to dissociate, releasing activated WASF1. The complex can also be activated by NCK1. Expression of this protein was found to be markedly reduced in patients with Alzheimer's disease.


:

Pssm-ID: 462866  Cd Length: 1114  Bit Score: 1948.99  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7305303      13 LAEKLTILNDRGVGMLTRLYNIKKACGDPKAKPSYLIDKNLESAVKFIVRKFPAVETRNNNQQLAQLQKEKSEILKNLAL 92
Cdd:pfam09735    1 LAEKLTILNDRGEGMLTRIYNIKKACGDPKSKPSFLSDKNLESAIKYIVKKFPNIDERSNSQGLDALQSRKEEILKSLSL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7305303      93 YYFTFVDVMEFKDHVCELLNTIDVCQVFFDITVNFDLTKNYLDLIITYTTLMILLSRIEERKAIIGLYNYAHEMTHGASD 172
Cdd:pfam09735   81 YYYTFVDLLDFKDHVYELLTTIDACQVHLDITLNFDLTKAYLDLVVTYVSLMLLLSRIEDRKAVLGLYNAAHEMLHGQSE 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7305303     173 REYPRLGQMIVDYENPLKKMMEEFVPHSKSLSDALISLQMVYPRRNLSADQWRNAQLLSLISAPSTMLNPAQSDTMPCEY 252
Cdd:pfam09735  161 PSYPRLGQMILDYDNPLKKLQEEFGPHSKLIGEALLSLGPVYPRRNLTADQWRSAQLLSLLSNPAQMLRPAQDDTMACEY 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7305303     253 LSLDAMEKWIIFGFILCHGILNTDaTALNLWKLALQSSSCLSLFRDEVFHIHKAAEDLFVNIRGYNKRINDIRECKEAAV 332
Cdd:pfam09735  241 LSLDVMERWILFGYLLCHGALATP-TSIDLWKRALQEGLVLTLFRDEVIYIHKEFQVLFENIKGYGKRKKDVKECAEQAL 319
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7305303     333 SHAGSMHRERRKFLRSALKELATVLSDQPGLLGPKALFVFMALSFARDEIIWLLRHADNMPKKS------ADDFIDKHIA 406
Cdd:pfam09735  320 QNAGALHRERRKYLRQALKELVLLLTDQPGLLGPKALFVFMALSFARDEVLWLFRHADNVPKKSkkkynkQEDLVDRQIA 399
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7305303     407 ELIFYMEELRAHVRKYGPVMQRYYVQYLSGFDAVVLNELVQNLSVCPEDESIIMSSFVNTMTSLSVKQVEDGEVFDFRGM 486
Cdd:pfam09735  400 ELLFYMEELRSLVRKYSQVIQRYYVQYLSGFDALVLNQTIQNLSVCPEEESIIMSSFVNTLSSLSVKQVENGEEFDFRGL 479
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7305303     487 RLDWFRLQAYTSVSKASLGLADHRELGKMMNTIIFHTKMVDSLVEMLVETSDLSIFCFYSRAFEKMFQQCLELPSQSRYS 566
Cdd:pfam09735  480 RLDWFRLQAYTSVSKSPLNLSENPDLASLMNLIVFHSKMVDSLDEMLVETSDLSILCFYPRIFEKMFDQCLESPAQPRYS 559
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7305303     567 IAFPLLCTHFMSCTHELCPEERHHIGDRSLSLCNMFLDEMAKQARNLITDICTEQCTLSDQLLPKHCAKTISQAVNKKSK 646
Cdd:pfam09735  560 IAFPLICSHFPSCTHELCPEERHHIGRRSLSLANSFLEEIAKEARNIITEICAEQCNLSDQLLPKHAAQTIAQARNKKKK 639
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7305303     647 KQTGKKGEPEREKPGVESMRKNRLVVTNLDKLHTALSELCFSINYVPNMVVWEHTFTPREYLTSHLEIRFTKSIVGMTMY 726
Cdd:pfam09735  640 KKKPKKGVPEPEKPGSESYRKDRENLTNLDKLHMALTELCSALNYCPEINVWDHVFAPREYLRQHLESRFKRALVGMATY 719
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7305303     727 NQATQEIAKPSELLTSVRAYMTVLQSIENYVQIDITRVFNNVLLQQTQHLDSHGEPTITSLYTNWYLETLLRQVSNGHIA 806
Cdd:pfam09735  720 NQATQEIARPSELLSSLRAYMSVLQSLENYVSIDVTRLFNNVLLQQTQPVDSHGEQTITTLYTNWYLDVLLRRVSSGGIV 799
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7305303     807 YFPAMKAFVNLPTENELTFNAEEYSDISEMRSLSELLGPYGMKFLSESLMWHISSQVAELKKLVVENVDVLTQMRTSFDK 886
Cdd:pfam09735  800 FSPNRKAFVSLSSEPGLPFNAEEYSDINELRALAELIGPYGMKFLNESLMWHIASQVAELKKLVTENMDVLVQLRSNFDK 879
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7305303     887 PDQMAALFKRLSSVDSVLKRMTIIGVILSFRSLAQEALRDVLSYHIPFLVSSIEDFKDHIPRETDMKVAMNVYELSSAAG 966
Cdd:pfam09735  880 PEQMKELLKRLKDVDNVLQRMTIIGVILSFRQLLQEALRDVLEERIPFLLSSIEDLKEHVPEETDIKEFLGVDELASAAG 959
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7305303     967 LPCEIDPALVVALSSQKSEniSPEEEYKIACLLMVFVAVSLPTLASNVMSQYSPAIEGHCNNIHCLAKAINQIAAALFTI 1046
Cdd:pfam09735  960 LPCDVDPALVAALRAQKTE--SPEEDYKVWCLLPVFVAVSLPSLAWKENSFYRPELEGHSNNIHCLATAINQLAAALFTI 1037
                         1050      1060      1070      1080      1090      1100      1110
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 7305303    1047 H-KGSIEDRLKEFLALASSSLLKIGQETDKTTTRNRESVYLLLDMIVQESPFLTMDLLESCFPYVLLRNAYHAVYKQ 1122
Cdd:pfam09735 1038 HgKRDIESRLKEFLALASSSLLRLGQETDKEVPKNRESVYLLLDQIVQESPFLTMDLLESCFPYVLLRNAYHAVYKA 1114
 
Name Accession Description Interval E-value
Nckap1 pfam09735
Nck-associated protein 1; Nck-associated protein 1 is part of lamellipodial complex that ...
13-1122 0e+00

Nck-associated protein 1; Nck-associated protein 1 is part of lamellipodial complex that controls Rac-dependent actin remodeling. It associates preferentially with the first SH3 domain of Nck and is a component of the WAVE2 complex composed of ABI1, CYFIP1/SRA1, NCKAP1/NAP1 and WASF2/WAVE2. It is also a component of the WAVE1 complex composed of ABI2, CYFIP2, C3orf10/HSPC300, NCKAP1 and WASF1/WAVE1. CYFIP2 binds to activated RAC1 which causes the complex to dissociate, releasing activated WASF1. The complex can also be activated by NCK1. Expression of this protein was found to be markedly reduced in patients with Alzheimer's disease.


Pssm-ID: 462866  Cd Length: 1114  Bit Score: 1948.99  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7305303      13 LAEKLTILNDRGVGMLTRLYNIKKACGDPKAKPSYLIDKNLESAVKFIVRKFPAVETRNNNQQLAQLQKEKSEILKNLAL 92
Cdd:pfam09735    1 LAEKLTILNDRGEGMLTRIYNIKKACGDPKSKPSFLSDKNLESAIKYIVKKFPNIDERSNSQGLDALQSRKEEILKSLSL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7305303      93 YYFTFVDVMEFKDHVCELLNTIDVCQVFFDITVNFDLTKNYLDLIITYTTLMILLSRIEERKAIIGLYNYAHEMTHGASD 172
Cdd:pfam09735   81 YYYTFVDLLDFKDHVYELLTTIDACQVHLDITLNFDLTKAYLDLVVTYVSLMLLLSRIEDRKAVLGLYNAAHEMLHGQSE 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7305303     173 REYPRLGQMIVDYENPLKKMMEEFVPHSKSLSDALISLQMVYPRRNLSADQWRNAQLLSLISAPSTMLNPAQSDTMPCEY 252
Cdd:pfam09735  161 PSYPRLGQMILDYDNPLKKLQEEFGPHSKLIGEALLSLGPVYPRRNLTADQWRSAQLLSLLSNPAQMLRPAQDDTMACEY 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7305303     253 LSLDAMEKWIIFGFILCHGILNTDaTALNLWKLALQSSSCLSLFRDEVFHIHKAAEDLFVNIRGYNKRINDIRECKEAAV 332
Cdd:pfam09735  241 LSLDVMERWILFGYLLCHGALATP-TSIDLWKRALQEGLVLTLFRDEVIYIHKEFQVLFENIKGYGKRKKDVKECAEQAL 319
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7305303     333 SHAGSMHRERRKFLRSALKELATVLSDQPGLLGPKALFVFMALSFARDEIIWLLRHADNMPKKS------ADDFIDKHIA 406
Cdd:pfam09735  320 QNAGALHRERRKYLRQALKELVLLLTDQPGLLGPKALFVFMALSFARDEVLWLFRHADNVPKKSkkkynkQEDLVDRQIA 399
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7305303     407 ELIFYMEELRAHVRKYGPVMQRYYVQYLSGFDAVVLNELVQNLSVCPEDESIIMSSFVNTMTSLSVKQVEDGEVFDFRGM 486
Cdd:pfam09735  400 ELLFYMEELRSLVRKYSQVIQRYYVQYLSGFDALVLNQTIQNLSVCPEEESIIMSSFVNTLSSLSVKQVENGEEFDFRGL 479
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7305303     487 RLDWFRLQAYTSVSKASLGLADHRELGKMMNTIIFHTKMVDSLVEMLVETSDLSIFCFYSRAFEKMFQQCLELPSQSRYS 566
Cdd:pfam09735  480 RLDWFRLQAYTSVSKSPLNLSENPDLASLMNLIVFHSKMVDSLDEMLVETSDLSILCFYPRIFEKMFDQCLESPAQPRYS 559
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7305303     567 IAFPLLCTHFMSCTHELCPEERHHIGDRSLSLCNMFLDEMAKQARNLITDICTEQCTLSDQLLPKHCAKTISQAVNKKSK 646
Cdd:pfam09735  560 IAFPLICSHFPSCTHELCPEERHHIGRRSLSLANSFLEEIAKEARNIITEICAEQCNLSDQLLPKHAAQTIAQARNKKKK 639
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7305303     647 KQTGKKGEPEREKPGVESMRKNRLVVTNLDKLHTALSELCFSINYVPNMVVWEHTFTPREYLTSHLEIRFTKSIVGMTMY 726
Cdd:pfam09735  640 KKKPKKGVPEPEKPGSESYRKDRENLTNLDKLHMALTELCSALNYCPEINVWDHVFAPREYLRQHLESRFKRALVGMATY 719
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7305303     727 NQATQEIAKPSELLTSVRAYMTVLQSIENYVQIDITRVFNNVLLQQTQHLDSHGEPTITSLYTNWYLETLLRQVSNGHIA 806
Cdd:pfam09735  720 NQATQEIARPSELLSSLRAYMSVLQSLENYVSIDVTRLFNNVLLQQTQPVDSHGEQTITTLYTNWYLDVLLRRVSSGGIV 799
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7305303     807 YFPAMKAFVNLPTENELTFNAEEYSDISEMRSLSELLGPYGMKFLSESLMWHISSQVAELKKLVVENVDVLTQMRTSFDK 886
Cdd:pfam09735  800 FSPNRKAFVSLSSEPGLPFNAEEYSDINELRALAELIGPYGMKFLNESLMWHIASQVAELKKLVTENMDVLVQLRSNFDK 879
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7305303     887 PDQMAALFKRLSSVDSVLKRMTIIGVILSFRSLAQEALRDVLSYHIPFLVSSIEDFKDHIPRETDMKVAMNVYELSSAAG 966
Cdd:pfam09735  880 PEQMKELLKRLKDVDNVLQRMTIIGVILSFRQLLQEALRDVLEERIPFLLSSIEDLKEHVPEETDIKEFLGVDELASAAG 959
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7305303     967 LPCEIDPALVVALSSQKSEniSPEEEYKIACLLMVFVAVSLPTLASNVMSQYSPAIEGHCNNIHCLAKAINQIAAALFTI 1046
Cdd:pfam09735  960 LPCDVDPALVAALRAQKTE--SPEEDYKVWCLLPVFVAVSLPSLAWKENSFYRPELEGHSNNIHCLATAINQLAAALFTI 1037
                         1050      1060      1070      1080      1090      1100      1110
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 7305303    1047 H-KGSIEDRLKEFLALASSSLLKIGQETDKTTTRNRESVYLLLDMIVQESPFLTMDLLESCFPYVLLRNAYHAVYKQ 1122
Cdd:pfam09735 1038 HgKRDIESRLKEFLALASSSLLRLGQETDKEVPKNRESVYLLLDQIVQESPFLTMDLLESCFPYVLLRNAYHAVYKA 1114
 
Name Accession Description Interval E-value
Nckap1 pfam09735
Nck-associated protein 1; Nck-associated protein 1 is part of lamellipodial complex that ...
13-1122 0e+00

Nck-associated protein 1; Nck-associated protein 1 is part of lamellipodial complex that controls Rac-dependent actin remodeling. It associates preferentially with the first SH3 domain of Nck and is a component of the WAVE2 complex composed of ABI1, CYFIP1/SRA1, NCKAP1/NAP1 and WASF2/WAVE2. It is also a component of the WAVE1 complex composed of ABI2, CYFIP2, C3orf10/HSPC300, NCKAP1 and WASF1/WAVE1. CYFIP2 binds to activated RAC1 which causes the complex to dissociate, releasing activated WASF1. The complex can also be activated by NCK1. Expression of this protein was found to be markedly reduced in patients with Alzheimer's disease.


Pssm-ID: 462866  Cd Length: 1114  Bit Score: 1948.99  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7305303      13 LAEKLTILNDRGVGMLTRLYNIKKACGDPKAKPSYLIDKNLESAVKFIVRKFPAVETRNNNQQLAQLQKEKSEILKNLAL 92
Cdd:pfam09735    1 LAEKLTILNDRGEGMLTRIYNIKKACGDPKSKPSFLSDKNLESAIKYIVKKFPNIDERSNSQGLDALQSRKEEILKSLSL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7305303      93 YYFTFVDVMEFKDHVCELLNTIDVCQVFFDITVNFDLTKNYLDLIITYTTLMILLSRIEERKAIIGLYNYAHEMTHGASD 172
Cdd:pfam09735   81 YYYTFVDLLDFKDHVYELLTTIDACQVHLDITLNFDLTKAYLDLVVTYVSLMLLLSRIEDRKAVLGLYNAAHEMLHGQSE 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7305303     173 REYPRLGQMIVDYENPLKKMMEEFVPHSKSLSDALISLQMVYPRRNLSADQWRNAQLLSLISAPSTMLNPAQSDTMPCEY 252
Cdd:pfam09735  161 PSYPRLGQMILDYDNPLKKLQEEFGPHSKLIGEALLSLGPVYPRRNLTADQWRSAQLLSLLSNPAQMLRPAQDDTMACEY 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7305303     253 LSLDAMEKWIIFGFILCHGILNTDaTALNLWKLALQSSSCLSLFRDEVFHIHKAAEDLFVNIRGYNKRINDIRECKEAAV 332
Cdd:pfam09735  241 LSLDVMERWILFGYLLCHGALATP-TSIDLWKRALQEGLVLTLFRDEVIYIHKEFQVLFENIKGYGKRKKDVKECAEQAL 319
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7305303     333 SHAGSMHRERRKFLRSALKELATVLSDQPGLLGPKALFVFMALSFARDEIIWLLRHADNMPKKS------ADDFIDKHIA 406
Cdd:pfam09735  320 QNAGALHRERRKYLRQALKELVLLLTDQPGLLGPKALFVFMALSFARDEVLWLFRHADNVPKKSkkkynkQEDLVDRQIA 399
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7305303     407 ELIFYMEELRAHVRKYGPVMQRYYVQYLSGFDAVVLNELVQNLSVCPEDESIIMSSFVNTMTSLSVKQVEDGEVFDFRGM 486
Cdd:pfam09735  400 ELLFYMEELRSLVRKYSQVIQRYYVQYLSGFDALVLNQTIQNLSVCPEEESIIMSSFVNTLSSLSVKQVENGEEFDFRGL 479
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7305303     487 RLDWFRLQAYTSVSKASLGLADHRELGKMMNTIIFHTKMVDSLVEMLVETSDLSIFCFYSRAFEKMFQQCLELPSQSRYS 566
Cdd:pfam09735  480 RLDWFRLQAYTSVSKSPLNLSENPDLASLMNLIVFHSKMVDSLDEMLVETSDLSILCFYPRIFEKMFDQCLESPAQPRYS 559
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7305303     567 IAFPLLCTHFMSCTHELCPEERHHIGDRSLSLCNMFLDEMAKQARNLITDICTEQCTLSDQLLPKHCAKTISQAVNKKSK 646
Cdd:pfam09735  560 IAFPLICSHFPSCTHELCPEERHHIGRRSLSLANSFLEEIAKEARNIITEICAEQCNLSDQLLPKHAAQTIAQARNKKKK 639
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7305303     647 KQTGKKGEPEREKPGVESMRKNRLVVTNLDKLHTALSELCFSINYVPNMVVWEHTFTPREYLTSHLEIRFTKSIVGMTMY 726
Cdd:pfam09735  640 KKKPKKGVPEPEKPGSESYRKDRENLTNLDKLHMALTELCSALNYCPEINVWDHVFAPREYLRQHLESRFKRALVGMATY 719
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7305303     727 NQATQEIAKPSELLTSVRAYMTVLQSIENYVQIDITRVFNNVLLQQTQHLDSHGEPTITSLYTNWYLETLLRQVSNGHIA 806
Cdd:pfam09735  720 NQATQEIARPSELLSSLRAYMSVLQSLENYVSIDVTRLFNNVLLQQTQPVDSHGEQTITTLYTNWYLDVLLRRVSSGGIV 799
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7305303     807 YFPAMKAFVNLPTENELTFNAEEYSDISEMRSLSELLGPYGMKFLSESLMWHISSQVAELKKLVVENVDVLTQMRTSFDK 886
Cdd:pfam09735  800 FSPNRKAFVSLSSEPGLPFNAEEYSDINELRALAELIGPYGMKFLNESLMWHIASQVAELKKLVTENMDVLVQLRSNFDK 879
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7305303     887 PDQMAALFKRLSSVDSVLKRMTIIGVILSFRSLAQEALRDVLSYHIPFLVSSIEDFKDHIPRETDMKVAMNVYELSSAAG 966
Cdd:pfam09735  880 PEQMKELLKRLKDVDNVLQRMTIIGVILSFRQLLQEALRDVLEERIPFLLSSIEDLKEHVPEETDIKEFLGVDELASAAG 959
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7305303     967 LPCEIDPALVVALSSQKSEniSPEEEYKIACLLMVFVAVSLPTLASNVMSQYSPAIEGHCNNIHCLAKAINQIAAALFTI 1046
Cdd:pfam09735  960 LPCDVDPALVAALRAQKTE--SPEEDYKVWCLLPVFVAVSLPSLAWKENSFYRPELEGHSNNIHCLATAINQLAAALFTI 1037
                         1050      1060      1070      1080      1090      1100      1110
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 7305303    1047 H-KGSIEDRLKEFLALASSSLLKIGQETDKTTTRNRESVYLLLDMIVQESPFLTMDLLESCFPYVLLRNAYHAVYKQ 1122
Cdd:pfam09735 1038 HgKRDIESRLKEFLALASSSLLRLGQETDKEVPKNRESVYLLLDQIVQESPFLTMDLLESCFPYVLLRNAYHAVYKA 1114
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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