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Conserved domains on  [gi|156231351|ref|NP_037521|]
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NPC1-like intracellular cholesterol transporter 1 isoform 1 precursor [Homo sapiens]

Protein Classification

Niemann-Pick C type protein family( domain architecture ID 1003172)

Niemann-Pick C (NPC) type protein family is essential for sterol homeostasis that drive sterol integration into the lysosomal membrane before redistribution to other cellular membranes

Gene Ontology:  GO:0015485|GO:0030301

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
2A060601 super family cl36767
Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in ...
 33-1293 0e+00

Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in eukaryotes. The defective protein has been associated with Niemann-Pick disease which is described in humans as autosomal recessive lipidosis. It is characterized by the lysosomal accumulation of unestrified cholesterol. It is an integral membrane protein, which indicates that this protein is most likely involved in cholesterol transport or acts as some component of cholesterol homeostasis. [Transport and binding proteins, Other]


The actual alignment was detected with superfamily member TIGR00917:

Pssm-ID: 273337 [Multi-domain]  Cd Length: 1205  Bit Score: 830.32  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231351    33 CAFYDECGKNPELSGslmtlsnVSCLSNTPARKITGDHLILLQKICPRLYTGPNTQACCSAKQLVSLEASLSITKALLTR 112
Cdd:TIGR00917    1 CAMYDICGARSDGKV-------LNCPYNIPSVKPPDLLSSLIQSLCQYSHPTISGNVCCTETQFDTLRSNVQQAIPFIVR 73

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231351   113 CPACSDNFVNLHCHNTCSPNQSLFINVTRVAQLGAGQlpAVVAYEAFYQHSFAEQSYDSCSRVRVPAAATLAVGTMCGVY 192
Cdd:TIGR00917   74 CPACLRNFLNLFCELTCSPDQSLFINVTSTTKVKTNS--TVDGIQYYITDDFAAGMYNSCKNVKFGSSNSRALDFLGGGA 151

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231351   193 GSAlCNAQRWLNFQGDTGNGLAPLDITFHLLEPGQAvgSGIQPLNEGVARCNESQGDDVATCSCQDCAASCPAIARPQAL 272
Cdd:TIGR00917  152 KNF-KEWFNWIGQKAGVNLPGAPYGIAFLPTPCPVS--SGMRPMNVSIYSCGDESLGCSCGDCPSAATCSCKAKVPTQKK 228

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231351   273 DS-TFYLGQMPGSLVLIIILcsvFAVVTILLVGFRVAPARDKSK------------------MVDPKKGTSLSDKLSFST 333
Cdd:TIGR00917  229 HScSIKLGVKCVDFILAILY---IVLVSVFLGGGLLHPVRGKKKtsqmgtlseadgeinsvnQQKDQNTPQRNWGQLSTV 305

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231351   334 HTLLGQFFQGWGTWVASWPLTILVLSVIPVVALAAGLVFTELTTDPVELWSAPNSQARSEKAFHDQHFGPFFRTNQVILT 413
Cdd:TIGR00917  306 QGHLARFFGKYGIWVARHPTLVICLSVSVVLLLCVGLIRFKVETRPVKLWVAPGSRAALEKQYFDTHFGPFYRIEQLIIA 385

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231351   414 APNRSSYrydslllgpKNFSGILDLDLLLELLELQERLrhLQVWSPEAQRNISLQDICYAPLNPdntslYDCCINSLLQY 493
Cdd:TIGR00917  386 TVQTSSH---------EKAPEILTDDNLKLLFDIQKKV--SQLFANYEGELITLDSPCFKPNHP-----YNCFIYSTCKK 449

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231351   494 FQNNRTLLLLTANQTLMGqtsqVDWKDHFLYCANAPLtfkdgtalalSCMADYGAPVFPFLAIGGYKGKDYSEAEALIMT 573
Cdd:TIGR00917  450 LQNMYSKLKPENYDDYGG----VDYVKYCFEHFTSPE----------SCLSAFGGPVDPTTVLGGFSGNNFSEASAFVVT 515

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231351   574 FSLNNYPAGDPRLAQAKLWEEAFLEEMRAFQRRMAgMFQVTFMAERSLEDEINRTTAEDLPIFATSYIVIFLYISLALGS 653
Cdd:TIGR00917  516 FPVNNFVNKTNKTEKAVAWEKAFIQLAKDELLPMV-QATISFSAERSIEDELKRESTADVITIAISYLVMFAYISLTLGD 594

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231351   654 YSSWSRVMVDSKATLGLGGVAVVLGAVMAAMGFFSYLGIRSSLVILQVVPFLVLSVGADNIFIFVLEYQRLPRRPGEPR- 732
Cdd:TIGR00917  595 SPRLKSLYVTSKVLLGLSGILIVMLSVLGSVGVFSAVGLKSTLIIMEVIPFLVLAVGVDNIFILVFFYFYLEYFYRQVGv 674

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231351   733 --------EVHIGRALGRVAPSMLLCSLSEAICFFLGALTPMPAVRTFALTSGLAVILDFLLQMSAFVALLSLDSKRQEA 804
Cdd:TIGR00917  675 dneqeltlERRLSRALMEVGPSITLASLSEILAFALGALIKMPAVRVFSMFAVLAVFLDFLLQITAFVALLVLDFKRTED 754

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231351   805 SRLDVCCCVKPQELPPPGQG------EGLLLGFFQKAYAPFLLHWITRGVVLLLFLALFGVSLYSMCHISVGLDQELALP 878
Cdd:TIGR00917  755 KRVDCFPCIKTSKSSISAEKgsgqrkAGLLTRYFKEVYAPVLLHWIVKIVVIAFFVGLLMAGIALSTRVEIGLDQQIVLP 834

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231351   879 KDSYLLDYFLFLNRYFEVGAPVYFVTTLGYNFSSEAGMNAICSSAGCNNFSFTQkiqyatEFPEQSYLAIPASSWVDDFI 958
Cdd:TIGR00917  835 QDSYLQIYFASLTPLLEVGPPFYIVIKGDYNYTDFESQNKLCTMGGCDKDSIVN------VFNNLSYIAKPASSWLDDYL 908

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231351   959 DWLTP-SSCCRLYisgPNKDKFCPSTVNSlnCLKNCMSITMGSVRPSVEQFHKYLPWFLNDRPNIKCPKGGLAAYSTSVN 1037
Cdd:TIGR00917  909 VWLSPqASCCCRK---FTNGTFCNGPDPQ--CFRCADLSSDAQGRPSTTQFKEKLPWFLNALPSADCAKGGHAAYSSAVD 983

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231351  1038 LtsdgqvldtvailsprLEYSGTISAhcnlylldstSRFMAYHKPLKNSQDYTEALRAARELAANITADLrkvpgtdpAF 1117
Cdd:TIGR00917  984 L----------------QGYATIIQA----------SSFRTYHTPLNTQVDFINAMRAAQEFAAKVSRSS--------KM 1029

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231351  1118 EVFPYTITNVFYEQYLTILPEGLFMLSLCLVPTFAVSCLLLGLDLRSGLLNLLSIVMILVDTVGFMALWGISYNAVSLIN 1197
Cdd:TIGR00917 1030 EVYPYSVFYVFFEQYLTIWKTAIINLSIALGAIFIVCLFLLQLNALSVVNLIMSVGMAVVFCVGIMHLWSISLNAVSVVN 1109

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231351  1198 LVSAVGMSVEFVSHITRSFAISTKPTWLERAKEATISMGSAVFAGVAMTNLPGILVLGLAKAQLIQIFFFRLNLLITLLG 1277
Cdd:TIGR00917 1110 SVMHKGIAIEFCTHINAQFSTGKHFSRNHRAKEALGGMGSSVFSGITLTKLVGVVVLGFSRSEIFVVYYFRMYLALVLLG 1189

                         1290
                   ....*....|....*.
gi 156231351  1278 LLHGLVFLPVILSYVG 1293
Cdd:TIGR00917 1190 FLHGLVFLPVLLSVLG 1205
 
Name Accession Description Interval E-value
2A060601 TIGR00917
Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in ...
 33-1293 0e+00

Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in eukaryotes. The defective protein has been associated with Niemann-Pick disease which is described in humans as autosomal recessive lipidosis. It is characterized by the lysosomal accumulation of unestrified cholesterol. It is an integral membrane protein, which indicates that this protein is most likely involved in cholesterol transport or acts as some component of cholesterol homeostasis. [Transport and binding proteins, Other]


Pssm-ID: 273337 [Multi-domain]  Cd Length: 1205  Bit Score: 830.32  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231351    33 CAFYDECGKNPELSGslmtlsnVSCLSNTPARKITGDHLILLQKICPRLYTGPNTQACCSAKQLVSLEASLSITKALLTR 112
Cdd:TIGR00917    1 CAMYDICGARSDGKV-------LNCPYNIPSVKPPDLLSSLIQSLCQYSHPTISGNVCCTETQFDTLRSNVQQAIPFIVR 73

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231351   113 CPACSDNFVNLHCHNTCSPNQSLFINVTRVAQLGAGQlpAVVAYEAFYQHSFAEQSYDSCSRVRVPAAATLAVGTMCGVY 192
Cdd:TIGR00917   74 CPACLRNFLNLFCELTCSPDQSLFINVTSTTKVKTNS--TVDGIQYYITDDFAAGMYNSCKNVKFGSSNSRALDFLGGGA 151

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231351   193 GSAlCNAQRWLNFQGDTGNGLAPLDITFHLLEPGQAvgSGIQPLNEGVARCNESQGDDVATCSCQDCAASCPAIARPQAL 272
Cdd:TIGR00917  152 KNF-KEWFNWIGQKAGVNLPGAPYGIAFLPTPCPVS--SGMRPMNVSIYSCGDESLGCSCGDCPSAATCSCKAKVPTQKK 228

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231351   273 DS-TFYLGQMPGSLVLIIILcsvFAVVTILLVGFRVAPARDKSK------------------MVDPKKGTSLSDKLSFST 333
Cdd:TIGR00917  229 HScSIKLGVKCVDFILAILY---IVLVSVFLGGGLLHPVRGKKKtsqmgtlseadgeinsvnQQKDQNTPQRNWGQLSTV 305

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231351   334 HTLLGQFFQGWGTWVASWPLTILVLSVIPVVALAAGLVFTELTTDPVELWSAPNSQARSEKAFHDQHFGPFFRTNQVILT 413
Cdd:TIGR00917  306 QGHLARFFGKYGIWVARHPTLVICLSVSVVLLLCVGLIRFKVETRPVKLWVAPGSRAALEKQYFDTHFGPFYRIEQLIIA 385

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231351   414 APNRSSYrydslllgpKNFSGILDLDLLLELLELQERLrhLQVWSPEAQRNISLQDICYAPLNPdntslYDCCINSLLQY 493
Cdd:TIGR00917  386 TVQTSSH---------EKAPEILTDDNLKLLFDIQKKV--SQLFANYEGELITLDSPCFKPNHP-----YNCFIYSTCKK 449

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231351   494 FQNNRTLLLLTANQTLMGqtsqVDWKDHFLYCANAPLtfkdgtalalSCMADYGAPVFPFLAIGGYKGKDYSEAEALIMT 573
Cdd:TIGR00917  450 LQNMYSKLKPENYDDYGG----VDYVKYCFEHFTSPE----------SCLSAFGGPVDPTTVLGGFSGNNFSEASAFVVT 515

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231351   574 FSLNNYPAGDPRLAQAKLWEEAFLEEMRAFQRRMAgMFQVTFMAERSLEDEINRTTAEDLPIFATSYIVIFLYISLALGS 653
Cdd:TIGR00917  516 FPVNNFVNKTNKTEKAVAWEKAFIQLAKDELLPMV-QATISFSAERSIEDELKRESTADVITIAISYLVMFAYISLTLGD 594

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231351   654 YSSWSRVMVDSKATLGLGGVAVVLGAVMAAMGFFSYLGIRSSLVILQVVPFLVLSVGADNIFIFVLEYQRLPRRPGEPR- 732
Cdd:TIGR00917  595 SPRLKSLYVTSKVLLGLSGILIVMLSVLGSVGVFSAVGLKSTLIIMEVIPFLVLAVGVDNIFILVFFYFYLEYFYRQVGv 674

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231351   733 --------EVHIGRALGRVAPSMLLCSLSEAICFFLGALTPMPAVRTFALTSGLAVILDFLLQMSAFVALLSLDSKRQEA 804
Cdd:TIGR00917  675 dneqeltlERRLSRALMEVGPSITLASLSEILAFALGALIKMPAVRVFSMFAVLAVFLDFLLQITAFVALLVLDFKRTED 754

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231351   805 SRLDVCCCVKPQELPPPGQG------EGLLLGFFQKAYAPFLLHWITRGVVLLLFLALFGVSLYSMCHISVGLDQELALP 878
Cdd:TIGR00917  755 KRVDCFPCIKTSKSSISAEKgsgqrkAGLLTRYFKEVYAPVLLHWIVKIVVIAFFVGLLMAGIALSTRVEIGLDQQIVLP 834

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231351   879 KDSYLLDYFLFLNRYFEVGAPVYFVTTLGYNFSSEAGMNAICSSAGCNNFSFTQkiqyatEFPEQSYLAIPASSWVDDFI 958
Cdd:TIGR00917  835 QDSYLQIYFASLTPLLEVGPPFYIVIKGDYNYTDFESQNKLCTMGGCDKDSIVN------VFNNLSYIAKPASSWLDDYL 908

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231351   959 DWLTP-SSCCRLYisgPNKDKFCPSTVNSlnCLKNCMSITMGSVRPSVEQFHKYLPWFLNDRPNIKCPKGGLAAYSTSVN 1037
Cdd:TIGR00917  909 VWLSPqASCCCRK---FTNGTFCNGPDPQ--CFRCADLSSDAQGRPSTTQFKEKLPWFLNALPSADCAKGGHAAYSSAVD 983

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231351  1038 LtsdgqvldtvailsprLEYSGTISAhcnlylldstSRFMAYHKPLKNSQDYTEALRAARELAANITADLrkvpgtdpAF 1117
Cdd:TIGR00917  984 L----------------QGYATIIQA----------SSFRTYHTPLNTQVDFINAMRAAQEFAAKVSRSS--------KM 1029

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231351  1118 EVFPYTITNVFYEQYLTILPEGLFMLSLCLVPTFAVSCLLLGLDLRSGLLNLLSIVMILVDTVGFMALWGISYNAVSLIN 1197
Cdd:TIGR00917 1030 EVYPYSVFYVFFEQYLTIWKTAIINLSIALGAIFIVCLFLLQLNALSVVNLIMSVGMAVVFCVGIMHLWSISLNAVSVVN 1109

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231351  1198 LVSAVGMSVEFVSHITRSFAISTKPTWLERAKEATISMGSAVFAGVAMTNLPGILVLGLAKAQLIQIFFFRLNLLITLLG 1277
Cdd:TIGR00917 1110 SVMHKGIAIEFCTHINAQFSTGKHFSRNHRAKEALGGMGSSVFSGITLTKLVGVVVLGFSRSEIFVVYYFRMYLALVLLG 1189

                         1290
                   ....*....|....*.
gi 156231351  1278 LLHGLVFLPVILSYVG 1293
Cdd:TIGR00917 1190 FLHGLVFLPVLLSVLG 1205
NPC1_N pfam16414
Niemann-Pick C1 N terminus; This is the N-terminal domain of Niemann-Pick C1 family proteins. ...
 31-283 4.39e-94

Niemann-Pick C1 N terminus; This is the N-terminal domain of Niemann-Pick C1 family proteins. This family of proteins mediates transport of cholesterol from the intestinal lumen to enterocytes. This domain contains a cholesterol-binding pocket.


Pssm-ID: 465110  Cd Length: 239  Bit Score: 302.60  E-value: 4.39e-94
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231351    31 GYCAFYDECGKNPELSGSLmtlsnvSCLSNTPARKITGDHLILLQKICPRLYTGpNTQACCSAKQLVSLEASLSITKALL 110
Cdd:pfam16414    1 GRCAWYGECGKKSLFGKDL------PCPYNGPAKPLDDEVRDLLAELCPLLFAD-ETPVCCDADQLNTLRSNLKLAEGLL 73

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231351   111 TRCPACSDNFVNLHCHNTCSPNQSLFINVTRVAQLGAGQLpAVVAYEAFYQHSFAEQSYDSCSRVRVPAAATLAVGTMCG 190
Cdd:pfam16414   74 SRCPACKKNFANLFCEFTCSPNQSTFLNVTKTKKSVDGKE-YVTELDYYISEEYASGFYDSCKDVKFPATNGYAMDLICG 152

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231351   191 VYgsalCNAQRWLNFQGDTGNGLAPLDITFHLlePGQAVGSGIQPLNEGVARCNESQGDDVAtCSCQDCAASCPAIARPQ 270
Cdd:pfam16414  153 GA----CNYTRWLKFMGDKKNGGSPFQINFPD--PPEEDPSGMVPLNPNTKDCNESYDASYA-CSCVDCPLSCPPPPQLP 225

                          250
                   ....*....|....
gi 156231351   271 ALDS-TFYLGQMPG 283
Cdd:pfam16414  226 PPPHgPCKVGGLDG 239
MMPL COG1033
Predicted exporter protein, RND superfamily [General function prediction only];
558-797 9.82e-17

Predicted exporter protein, RND superfamily [General function prediction only];


Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 86.07  E-value: 9.82e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231351  558 GYKGKDYSE-AEALIMTFSLNNYPAGDPrLAQAKLWE--EAFLEEMRA--FQRRMAGMFQVTfmaersleDEINRTTAED 632
Cdd:COG1033   149 LYVGRLVSPdGKATLIVVTLDPDPLSSD-LDRKEVVAeiRAIIAKYEDpgVEVYLTGFPVLR--------GDIAEAIQSD 219

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231351  633 LPIF-ATSYIVIFLYISLALGSYSSWsrvmvdskatlgLGGVAVVLGAVMAAMGFFSYLGIRSSlVILQVVPFLVLSVGA 711
Cdd:COG1033   220 LAIFfPLALLLILLLLFLFFRSLRGV------------LLPLLVVLLAVIWTLGLMGLLGIPLS-PLTILVPPLLLAIGI 286

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231351  712 DNIFIFVLEYQRLpRRPGEPREVHIGRALGRVAPSMLLCSLSEAICFFLGALTPMPAVRTFALTSGLAVILDFLLQMSAF 791
Cdd:COG1033   287 DYGIHLLNRYREE-RRKGLDKREALREALRKLGPPVLLTSLTTAIGFLSLLFSDIPPIRDFGIVAAIGVLLAFLTSLTLL 365


                  ....*.
gi 156231351  792 VALLSL 797
Cdd:COG1033   366 PALLSL 371
 
Name Accession Description Interval E-value
2A060601 TIGR00917
Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in ...
 33-1293 0e+00

Niemann-Pick C type protein family; The model describes Niemann-Pick C type protein in eukaryotes. The defective protein has been associated with Niemann-Pick disease which is described in humans as autosomal recessive lipidosis. It is characterized by the lysosomal accumulation of unestrified cholesterol. It is an integral membrane protein, which indicates that this protein is most likely involved in cholesterol transport or acts as some component of cholesterol homeostasis. [Transport and binding proteins, Other]


Pssm-ID: 273337 [Multi-domain]  Cd Length: 1205  Bit Score: 830.32  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231351    33 CAFYDECGKNPELSGslmtlsnVSCLSNTPARKITGDHLILLQKICPRLYTGPNTQACCSAKQLVSLEASLSITKALLTR 112
Cdd:TIGR00917    1 CAMYDICGARSDGKV-------LNCPYNIPSVKPPDLLSSLIQSLCQYSHPTISGNVCCTETQFDTLRSNVQQAIPFIVR 73

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231351   113 CPACSDNFVNLHCHNTCSPNQSLFINVTRVAQLGAGQlpAVVAYEAFYQHSFAEQSYDSCSRVRVPAAATLAVGTMCGVY 192
Cdd:TIGR00917   74 CPACLRNFLNLFCELTCSPDQSLFINVTSTTKVKTNS--TVDGIQYYITDDFAAGMYNSCKNVKFGSSNSRALDFLGGGA 151

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231351   193 GSAlCNAQRWLNFQGDTGNGLAPLDITFHLLEPGQAvgSGIQPLNEGVARCNESQGDDVATCSCQDCAASCPAIARPQAL 272
Cdd:TIGR00917  152 KNF-KEWFNWIGQKAGVNLPGAPYGIAFLPTPCPVS--SGMRPMNVSIYSCGDESLGCSCGDCPSAATCSCKAKVPTQKK 228

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231351   273 DS-TFYLGQMPGSLVLIIILcsvFAVVTILLVGFRVAPARDKSK------------------MVDPKKGTSLSDKLSFST 333
Cdd:TIGR00917  229 HScSIKLGVKCVDFILAILY---IVLVSVFLGGGLLHPVRGKKKtsqmgtlseadgeinsvnQQKDQNTPQRNWGQLSTV 305

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231351   334 HTLLGQFFQGWGTWVASWPLTILVLSVIPVVALAAGLVFTELTTDPVELWSAPNSQARSEKAFHDQHFGPFFRTNQVILT 413
Cdd:TIGR00917  306 QGHLARFFGKYGIWVARHPTLVICLSVSVVLLLCVGLIRFKVETRPVKLWVAPGSRAALEKQYFDTHFGPFYRIEQLIIA 385

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231351   414 APNRSSYrydslllgpKNFSGILDLDLLLELLELQERLrhLQVWSPEAQRNISLQDICYAPLNPdntslYDCCINSLLQY 493
Cdd:TIGR00917  386 TVQTSSH---------EKAPEILTDDNLKLLFDIQKKV--SQLFANYEGELITLDSPCFKPNHP-----YNCFIYSTCKK 449

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231351   494 FQNNRTLLLLTANQTLMGqtsqVDWKDHFLYCANAPLtfkdgtalalSCMADYGAPVFPFLAIGGYKGKDYSEAEALIMT 573
Cdd:TIGR00917  450 LQNMYSKLKPENYDDYGG----VDYVKYCFEHFTSPE----------SCLSAFGGPVDPTTVLGGFSGNNFSEASAFVVT 515

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231351   574 FSLNNYPAGDPRLAQAKLWEEAFLEEMRAFQRRMAgMFQVTFMAERSLEDEINRTTAEDLPIFATSYIVIFLYISLALGS 653
Cdd:TIGR00917  516 FPVNNFVNKTNKTEKAVAWEKAFIQLAKDELLPMV-QATISFSAERSIEDELKRESTADVITIAISYLVMFAYISLTLGD 594

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231351   654 YSSWSRVMVDSKATLGLGGVAVVLGAVMAAMGFFSYLGIRSSLVILQVVPFLVLSVGADNIFIFVLEYQRLPRRPGEPR- 732
Cdd:TIGR00917  595 SPRLKSLYVTSKVLLGLSGILIVMLSVLGSVGVFSAVGLKSTLIIMEVIPFLVLAVGVDNIFILVFFYFYLEYFYRQVGv 674

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231351   733 --------EVHIGRALGRVAPSMLLCSLSEAICFFLGALTPMPAVRTFALTSGLAVILDFLLQMSAFVALLSLDSKRQEA 804
Cdd:TIGR00917  675 dneqeltlERRLSRALMEVGPSITLASLSEILAFALGALIKMPAVRVFSMFAVLAVFLDFLLQITAFVALLVLDFKRTED 754

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231351   805 SRLDVCCCVKPQELPPPGQG------EGLLLGFFQKAYAPFLLHWITRGVVLLLFLALFGVSLYSMCHISVGLDQELALP 878
Cdd:TIGR00917  755 KRVDCFPCIKTSKSSISAEKgsgqrkAGLLTRYFKEVYAPVLLHWIVKIVVIAFFVGLLMAGIALSTRVEIGLDQQIVLP 834

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231351   879 KDSYLLDYFLFLNRYFEVGAPVYFVTTLGYNFSSEAGMNAICSSAGCNNFSFTQkiqyatEFPEQSYLAIPASSWVDDFI 958
Cdd:TIGR00917  835 QDSYLQIYFASLTPLLEVGPPFYIVIKGDYNYTDFESQNKLCTMGGCDKDSIVN------VFNNLSYIAKPASSWLDDYL 908

                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231351   959 DWLTP-SSCCRLYisgPNKDKFCPSTVNSlnCLKNCMSITMGSVRPSVEQFHKYLPWFLNDRPNIKCPKGGLAAYSTSVN 1037
Cdd:TIGR00917  909 VWLSPqASCCCRK---FTNGTFCNGPDPQ--CFRCADLSSDAQGRPSTTQFKEKLPWFLNALPSADCAKGGHAAYSSAVD 983

                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231351  1038 LtsdgqvldtvailsprLEYSGTISAhcnlylldstSRFMAYHKPLKNSQDYTEALRAARELAANITADLrkvpgtdpAF 1117
Cdd:TIGR00917  984 L----------------QGYATIIQA----------SSFRTYHTPLNTQVDFINAMRAAQEFAAKVSRSS--------KM 1029

                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231351  1118 EVFPYTITNVFYEQYLTILPEGLFMLSLCLVPTFAVSCLLLGLDLRSGLLNLLSIVMILVDTVGFMALWGISYNAVSLIN 1197
Cdd:TIGR00917 1030 EVYPYSVFYVFFEQYLTIWKTAIINLSIALGAIFIVCLFLLQLNALSVVNLIMSVGMAVVFCVGIMHLWSISLNAVSVVN 1109

                         1210      1220      1230      1240      1250      1260      1270      1280
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231351  1198 LVSAVGMSVEFVSHITRSFAISTKPTWLERAKEATISMGSAVFAGVAMTNLPGILVLGLAKAQLIQIFFFRLNLLITLLG 1277
Cdd:TIGR00917 1110 SVMHKGIAIEFCTHINAQFSTGKHFSRNHRAKEALGGMGSSVFSGITLTKLVGVVVLGFSRSEIFVVYYFRMYLALVLLG 1189

                         1290
                   ....*....|....*.
gi 156231351  1278 LLHGLVFLPVILSYVG 1293
Cdd:TIGR00917 1190 FLHGLVFLPVLLSVLG 1205
NPC1_N pfam16414
Niemann-Pick C1 N terminus; This is the N-terminal domain of Niemann-Pick C1 family proteins. ...
 31-283 4.39e-94

Niemann-Pick C1 N terminus; This is the N-terminal domain of Niemann-Pick C1 family proteins. This family of proteins mediates transport of cholesterol from the intestinal lumen to enterocytes. This domain contains a cholesterol-binding pocket.


Pssm-ID: 465110  Cd Length: 239  Bit Score: 302.60  E-value: 4.39e-94
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231351    31 GYCAFYDECGKNPELSGSLmtlsnvSCLSNTPARKITGDHLILLQKICPRLYTGpNTQACCSAKQLVSLEASLSITKALL 110
Cdd:pfam16414    1 GRCAWYGECGKKSLFGKDL------PCPYNGPAKPLDDEVRDLLAELCPLLFAD-ETPVCCDADQLNTLRSNLKLAEGLL 73

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231351   111 TRCPACSDNFVNLHCHNTCSPNQSLFINVTRVAQLGAGQLpAVVAYEAFYQHSFAEQSYDSCSRVRVPAAATLAVGTMCG 190
Cdd:pfam16414   74 SRCPACKKNFANLFCEFTCSPNQSTFLNVTKTKKSVDGKE-YVTELDYYISEEYASGFYDSCKDVKFPATNGYAMDLICG 152

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231351   191 VYgsalCNAQRWLNFQGDTGNGLAPLDITFHLlePGQAVGSGIQPLNEGVARCNESQGDDVAtCSCQDCAASCPAIARPQ 270
Cdd:pfam16414  153 GA----CNYTRWLKFMGDKKNGGSPFQINFPD--PPEEDPSGMVPLNPNTKDCNESYDASYA-CSCVDCPLSCPPPPQLP 225

                          250
                   ....*....|....
gi 156231351   271 ALDS-TFYLGQMPG 283
Cdd:pfam16414  226 PPPHgPCKVGGLDG 239
Sterol-sensing pfam12349
Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins ...
 661-814 1.45e-60

Sterol-sensing domain of SREBP cleavage-activation; Sterol regulatory element-binding proteins (SREBPs) are membrane-bound transcription factors that promote lipid synthesis in animal cells. They are embedded in the membranes of the endoplasmic reticulum (ER) in a helical hairpin orientation and are released from the ER by a two-step proteolytic process. Proteolysis begins when the SREBPs are cleaved at Site-1, which is located at a leucine residue in the middle of the hydrophobic loop in the lumen of the ER. Upon proteolytic processing SREBP can activate the expression of genes involved in cholesterol biosynthesis and uptake. SCAP stimulates cleavage of SREBPs via fusion of the their two C-termini. This domain is the transmembrane region that traverses the membrane eight times and is the sterol-sensing domain of the cleavage protein. WD40 domains are found towards the C-terminus.


Pssm-ID: 463544 [Multi-domain]  Cd Length: 153  Bit Score: 204.35  E-value: 1.45e-60
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231351   661 MVDSKATLGLGGVAVVLGAVMAAMGFFSYLGIRSSLVILQVVPFLVLSVGADNIFIFVLEYQRLPRRPGEPRevHIGRAL 740
Cdd:pfam12349    1 MVKSKFGLGLAGVIIVLASVASSLGLCAYFGLPLTLIISEVIPFLVLAIGVDNIFLLVKAVVRTPRSLDVSE--RIAEAL 78

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 156231351   741 GRVAPSMLLCSLSEAICFFLGALTPMPAVRTFALTSGLAVILDFLLQMSAFVALLSLDSKRQEASRLDVCCCVK 814
Cdd:pfam12349   79 GEVGPSITLTSLTEILAFLLGALTDMPAVQEFCLFAAVAVLFDFLLQMTFFVAVLSLDIRRLESNRLDVACCIR 152
Patched pfam02460
Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic ...
 598-1266 2.94e-53

Patched family; The transmembrane protein Patched is a receptor for the morphogene Sonic Hedgehog. This protein associates with the smoothened protein to transduce hedgehog signals.


Pssm-ID: 308203 [Multi-domain]  Cd Length: 793  Bit Score: 201.43  E-value: 2.94e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231351   598 EEMRAFQRRMAGMF----------QVTFMAERSLEDEINRTTAEDLPIFATSYIVIFLYISLALGSYSSWSRVMVDSKAT 667
Cdd:pfam02460  171 EEDSKEWEDELSQLlhnkyasehiQFTIFHDQILNDELVRNALTLTPFFVIGFFLLLTFSIIVSVTLSSYTIDWVRSKPI 250

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231351   668 LGLGGVAVVLGAVMAAMGFFSYLGIRSSlVILQVVPFLVLSVGADNIFIFVLEYQRLPRRPGEPREvhIGRALGRVAPSM 747
Cdd:pfam02460  251 LAALGLLSPVMAIVSSFGLLFWMGFPFN-SIVCVTPFLVLAIGVDDMFLMVAAWQRTTATLSVKKR--MGEALSEAGVSI 327

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231351   748 LLCSLSEAICFFLGALTPMPAVRTFALTSGLAVILDFLLQMSAFVALLSLDSKRQEASR--LDVCCCVKPQEL------P 819
Cdd:pfam02460  328 TITSLTDVLSFGIGTYTPTPAIQLFCAYTAVAIFFDFIYQITFFAAIMAICAKPEAEGRhcLFVWATSSPQRIdsegseP 407

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231351   820 PPGQG-EGLLLGFFQKAYAPFLLHWITRGVVLLLFLALFGVSLYSMCHISVGLDQELALPKDSYLLDYFLFLNRYFevga 898
Cdd:pfam02460  408 DKSHNiEQLKSRFFLDIYCPFLLNPSVRVCMLVLFVVYIAIAIYGCVNIKEGLEPDKLVLEDSPLVEYLSLREKHF---- 483

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231351   899 pvyfvttlgynfsseagmnaicssagcnnfsftqkiqyateFPEqsYLAipasswvddfidwltpsscCRLYISGPnKDK 978
Cdd:pfam02460  484 -----------------------------------------WPE--GLQ-------------------IQVAVNNP-PNL 500

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231351   979 FCPSTVNSLNCLKNCMSITMGSVRPSVEQFhkYLPWFLNDRpnikcpkgglaaYSTSVNLTSDGQVLDTVAILSPRLEYS 1058
Cdd:pfam02460  501 TIPESRDRMNEMVDEFENTPYSLGPNSTLF--WLREYENFL------------STLNMEEEEDEEKEWSYGNLPSFLKAP 566

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231351  1059 GTISAHCNLYLLDSTSRFMAYH-----KPLKNSQDYTEalraarelaanITADLRKVPGTDPAFEVFPYTITNVFYEQYL 1133
Cdd:pfam02460  567 GNSHWAGDLVWDDNTTMVTKFRftlagKGLSTWNDRTR-----------ALQEWRSIADQYPEFNVTVFDEDAPFADQYL 635

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231351  1134 TILPEGLFMLSLCLVPTFAVsCLLLGLDLRSGLLNLLSIVMILVDTVGFMALWGISYNAVSLINLVSAVGMSVEFVSHIT 1213
Cdd:pfam02460  636 TILPSTIQNIVITLICMFIV-CFLFIPNPPCVFVITLAIASIDIGVFGFLSLWGVDLDPISMITIIMSIGFSVDFSAHIA 714

                          650       660       670       680       690
                   ....*....|....*....|....*....|....*....|....*....|...
gi 156231351  1214 RSFAISTKPTWLERAKEATISMGSAVFAGvAMTNLPGILVLGLAKAQLIQIFF 1266
Cdd:pfam02460  715 YHFVRSRGDTPAERVVDALEALGWPVFQG-GLSTILGVLVLLFVPSYMVVVFF 766
2A060602 TIGR00918
The Eukaryotic (Putative) Sterol Transporter (EST) Family;
592-1299 6.98e-35

The Eukaryotic (Putative) Sterol Transporter (EST) Family;


Pssm-ID: 273338 [Multi-domain]  Cd Length: 1145  Bit Score: 145.41  E-value: 6.98e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231351   592 WEEAFLEEMRAFQRRMAGmFQVTFMAERSLEDEINRTTAEDLPIFATSYIVIFLYISLALGSYSSwsrvmVDSKATLGLG 671
Cdd:TIGR00918  359 WQRNFSEEVQQSLPKNSS-QKILVFSSTTLDDILKKFSDVSAIRIVSGYLLMLAYACLTMLRWDC-----AKSQGSVGLA 432

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231351   672 GVAVVLGAVMAAMGFFSYLGIRSSLVILQVVPFLVLSVGADNIFIFVLEY-QRLPRRPGEPRevhIGRALGRVAPSMLLC 750
Cdd:TIGR00918  433 GVLLVALSVAAGLGLCALLGISFNAATTQVLPFLALGVGVDDVFLLAHAFsETGQNIPFEER---TGECLKRTGASVVLT 509

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231351   751 SLSEAICFFLGALTPMPAVRTFALTSGLAVILDFLLQMSAFVALLSLDSKRQEASRLDV-CCCVKP------QELP---- 819
Cdd:TIGR00918  510 SISNVTAFFMAALIPIPALRAFSLQAAIVVVFNFAAVLLVFPAILSLDLRRREDRRLDIfCCFFSPcsarviQIEPqaya 589

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231351   820 -----------------------------------------------------PPGQGEGL------------------- 827
Cdd:TIGR00918  590 dgsappvysshmqstvqlrteydpgtqhyyttneprshlsvqpsdplscqspdIAGSTRDLlsqfedskaaclslpcarw 669

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231351   828 -LLGFFQKAYAPFLLHWITRGVVLLLFLALFGVSLYSMCHISVGLDQELALPKDSYLLDYFLFLNRYFEVgAPVYFVTTL 906
Cdd:TIGR00918  670 tLATFAEKHYAPFLLQSWAKVVVIFLFLALLGLSLYGTTRVQDGLDLTDIVPRDTNEHDFLDAQFRYFSF-YNMYAVTQG 748

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231351   907 GYNFSSeagmnaicssagcnnfsftqkIQYATEFPEQSYLAIPA----------SSWVDDFIDWLtpssccrlyiSGPNK 976
Cdd:TIGR00918  749 NFDYPT---------------------QQQLLYDLHQSFSSVKYvlkedngqlpRMWLHYFRDWL----------QGLQK 797

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231351   977 --DKFCPSTVNSLNCLKNCMSITMGSVRPSVEQFHKYLPwflndrpnikcpkgglaaysTSVNLTSDGQVLDTVAILSPR 1054
Cdd:TIGR00918  798 afDEDWRDGRITKENYRNGSDDAVLAYKLLVQTGHRDKP--------------------VDKEQLTTQRLVNADGIINPN 857

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231351  1055 LEYSGTISAHCNLYLLDSTSRFMAYHKP---LKNSQDYTEALRAARELAANITAD-------LRKVPGTDPAFE------ 1118
Cdd:TIGR00918  858 AFYIYLSAWVSNDPVAYAASQANIYPHPpewLHDKNDYDPENLRIPAAEPLEYAQfpfylngLRETSQFVEAIEhvraic 937

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231351  1119 ---------VFPYTITNVFYEQYLTILPEGLFMLSLCLVPTFAVSCLLLgLDLRSGLLNLLSIVMILVDTVGFMALWGIS 1189
Cdd:TIGR00918  938 nnyegfglpSYPSGYPFLFWEQYMGLRHWLLLSISVVLACTFLVCALLL-LNPWTAGLIVLVLALMTVELFGMMGLLGIK 1016

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231351  1190 YNAVSLINLVSAVGMSVEFVSHITRSFAISTKptwlERAKEATISMgSAVFAGV---AMTNLPGILVLGLAKAQLIQIFF 1266
Cdd:TIGR00918 1017 LSAIPVVILIASVGIGVEFTVHIALGFLTAIG----DRNRRAVLAL-EHMFAPVldgALSTLLGVLMLAGSEFDFIVRYF 1091

                          810       820       830
                   ....*....|....*....|....*....|....*
gi 156231351  1267 FRLNLLITLLGLLHGLVFLPVILSYVGP--DVNPA 1299
Cdd:TIGR00918 1092 FAVLAVLTCLGVLNGLVLLPVLLSMFGPepEVSPA 1126
MMPL COG1033
Predicted exporter protein, RND superfamily [General function prediction only];
558-797 9.82e-17

Predicted exporter protein, RND superfamily [General function prediction only];


Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 86.07  E-value: 9.82e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231351  558 GYKGKDYSE-AEALIMTFSLNNYPAGDPrLAQAKLWE--EAFLEEMRA--FQRRMAGMFQVTfmaersleDEINRTTAED 632
Cdd:COG1033   149 LYVGRLVSPdGKATLIVVTLDPDPLSSD-LDRKEVVAeiRAIIAKYEDpgVEVYLTGFPVLR--------GDIAEAIQSD 219

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231351  633 LPIF-ATSYIVIFLYISLALGSYSSWsrvmvdskatlgLGGVAVVLGAVMAAMGFFSYLGIRSSlVILQVVPFLVLSVGA 711
Cdd:COG1033   220 LAIFfPLALLLILLLLFLFFRSLRGV------------LLPLLVVLLAVIWTLGLMGLLGIPLS-PLTILVPPLLLAIGI 286

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231351  712 DNIFIFVLEYQRLpRRPGEPREVHIGRALGRVAPSMLLCSLSEAICFFLGALTPMPAVRTFALTSGLAVILDFLLQMSAF 791
Cdd:COG1033   287 DYGIHLLNRYREE-RRKGLDKREALREALRKLGPPVLLTSLTTAIGFLSLLFSDIPPIRDFGIVAAIGVLLAFLTSLTLL 365


                  ....*.
gi 156231351  792 VALLSL 797
Cdd:COG1033   366 PALLSL 371
MMPL COG1033
Predicted exporter protein, RND superfamily [General function prediction only];
286-797 3.52e-07

Predicted exporter protein, RND superfamily [General function prediction only];


Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 54.87  E-value: 3.52e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231351  286 VLIIILCSVFaVVTILLVGFRVAPARDKSKmvdpkkgtslsdklsfSTHTLLGQFFQGWGTWVASWPLTILVLSVIPVVA 365
Cdd:COG1033   354 VLLAFLTSLT-LLPALLSLLPRPKPKTRRL----------------KKPPELGRLLAKLARFVLRRPKVILVVALVLAVV 416

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231351  366 LAAGLVFTELTTDPVElWSAPNSQARSEKAFHDQHFG---PFFrtnqVILTAPNRSSYRYDSLLlgpknfsgildldlll 442
Cdd:COG1033   417 SLYGISRLKVEYDFED-YLPEDSPIRQDLDFIEENFGgsdPLE----VVVDTGEPDGLKDPEVL---------------- 475

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231351  443 ellelqERLRHLQVW---SPEAQRNISLQDIcyapLNPDNTSLYDccinsllqyfqNNRTLLLLTANQTLMGQtsqvdwk 519
Cdd:COG1033   476 ------KEIDRLQDYlesLPEVGKVLSLADL----VKELNQALNE-----------GDPKYYALPESRELLAQ------- 527

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231351  520 dhflycanapltfkdgtalalscmADYGAPVFPFLAIGGYKGKDYSEAealIMTFSLNNypagdprLAQAKLweEAFLEE 599
Cdd:COG1033   528 ------------------------LLLLLSSPPGDDLSRFVDEDYSAA---RVTVRLKD-------LDSEEI--KALVEE 571

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231351  600 MRAFQRRMAGMFQVTFMA--ERSLEDEINRTTAEDLP-IFATSYIVIFLYISLALGSYSswsrvmvdskatLGLGGVAVV 676
Cdd:COG1033   572 VRAFLAENFPPDGVEVTLtgSAVLFAAINESVIESQIrSLLLALLLIFLLLLLAFRSLR------------LGLISLIPN 639

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231351  677 LGAVMAAMGFFSYLGIRsslviLQVVPFLVLSV----GADNiFIFVLEYQRLPRRPGEPREVHIGRALGRVAPSMLLCSL 752
Cdd:COG1033   640 LLPILLTFGLMGLLGIP-----LNIATAVVASIalgiGVDY-TIHFLSRYREERRKGGDLEEAIRRALRTTGKAILFTSL 713

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*
gi 156231351  753 SEAICFFLGALTPMPAVRTFALTSGLAVILDFLLQMSAFVALLSL 797
Cdd:COG1033   714 TLAAGFGVLLFSSFPPLADFGLLLALGLLVALLAALLLLPALLLL 758
2A067 TIGR00921
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ...
 613-818 6.51e-07

The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273340 [Multi-domain]  Cd Length: 719  Bit Score: 54.07  E-value: 6.51e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231351   613 VTFMAERSLEDEINRTTAedlpifatsyIVIFLYISLALGSYSSWSRvmvdskatlGLGGVAVVLGAVMAAMGFFSYLGI 692
Cdd:TIGR00921  183 INYDIEREFGKDMGTTMA----------ISGILVVLVLLLDFKRWWR---------PLLPLVIILFGVAWVLGIMGWLGI 243

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231351   693 RSSLVILQVVPfLVLSVGADNIFIFVLEYQRlprrpgeprEVHIGRALG--------RVAPSMLLCSLSEAICFFLGALT 764
Cdd:TIGR00921  244 PLYATTLLAVP-MLIGVGIDYGIQTLNRYEE---------ERDIGRAKGeaivtavrRTGRAVLIALLTTSAGFAALALS 313

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 156231351   765 PMPAVRTFALTSGLAVILDFLLQMSAFVALL-SLDSKRQEASRLDVCCCVKPQEL 818
Cdd:TIGR00921  314 EFPMVSEFGLGLVAGLITAYLLTLLVLPALLqSIDIGREKVKKEIIAIGGKSSEI 368
MMPL pfam03176
MMPL family; Members of this family are putative integral membrane proteins from bacteria. ...
 666-801 2.22e-06

MMPL family; Members of this family are putative integral membrane proteins from bacteria. Several of the members are mycobacterial proteins. Many of the proteins contain two copies of this aligned region. The function of these proteins is not known, although it has been suggested that they may be involved in lipid transport.


Pssm-ID: 308676 [Multi-domain]  Cd Length: 332  Bit Score: 51.52  E-value: 2.22e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231351   666 ATLGLGGVAVVLGAVMAAMGFFSY---LGIRSSLVILQVVpfLVLSVGAD-NIFIfVLEYQRlPRRPGEPREVHIGRALG 741
Cdd:pfam03176  169 ALLPLLTVGLSLGAAQGLVAILAHilgIGLSTFALNLLVV--LLIAVGTDyALFL-VSRYRE-ELRAGEDREEAVIRAVR 244

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231351   742 RVAPSMLLCSLSEAICFFLGALTPMPAVRTFALTSGLAVILDFLLQMSAFVALLSLDSKR 801
Cdd:pfam03176  245 GTGKVVTAAGLTVAIAMLALSFARLPVFAQVGPTIAIGVLVDVLAALTLLPALLALLGRW 304
COG4258 COG4258
Predicted exporter [General function prediction only];
639-786 1.20e-05

Predicted exporter [General function prediction only];


Pssm-ID: 443400 [Multi-domain]  Cd Length: 783  Bit Score: 49.85  E-value: 1.20e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231351  639 SYIVIFLYISLALGSyssWSRVmvdskatlgLGGVAVVLGAVMAAMGFFSYLGIRSSLVILqVVPFLVLSVGAD-NIFIf 717
Cdd:COG4258   648 ALLLILLLLLLRLRS---LRRA---------LRVLLPPLLAVLLTLAILGLLGIPLNLFHL-IALLLVLGIGIDyALFF- 713

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 156231351  718 vleyQRLPRRPGEPRevhigralgRVAPSMLLCSLSEAICFFLGALTPMPAVRTFALTSGLAVILDFLL 786
Cdd:COG4258   714 ----TEGLLDKGELA---------RTLLSILLAALTTLLGFGLLAFSSTPALRSFGLTVLLGILLALLL 769
2A067 TIGR00921
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ...
 665-797 6.22e-05

The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273340 [Multi-domain]  Cd Length: 719  Bit Score: 47.52  E-value: 6.22e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231351   665 KATLGLGGVAVVLGAVMAAMGFfsyLGIRSSLvILQVVPFLVLSVGADnIFIFVLEYQRLPRRPGEPREVhIGRALGRVA 744
Cdd:TIGR00921  593 KAVFPLIAIGSGILWAIGLMGL---RGIPSFL-AMATTISIILGLGMD-YSIHLAERYFEERKEHGPKEA-ITHTMERTG 666

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 156231351   745 PSMLLCSLSEAICFFLGALTPMPAVRTFALTSGLAVILDFLLQMSAFVALLSL 797
Cdd:TIGR00921  667 PGILFSGLTTAGGFLSLLLSHFPIMRNFGLVQGIGVLSSLTAALVVFPALLVL 719
MMPL COG1033
Predicted exporter protein, RND superfamily [General function prediction only];
1150-1265 6.54e-04

Predicted exporter protein, RND superfamily [General function prediction only];


Pssm-ID: 440656 [Multi-domain]  Cd Length: 767  Bit Score: 44.08  E-value: 6.54e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231351 1150 TFAVSCLLLGL---DLRSGLLNLLSIVMILVDTVGFMALWGISYNAVS--LINLVSAVGMS--VEFVSHITRSFAISTKP 1222
Cdd:COG1033   227 ALLLILLLLFLffrSLRGVLLPLLVVLLAVIWTLGLMGLLGIPLSPLTilVPPLLLAIGIDygIHLLNRYREERRKGLDK 306

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 156231351 1223 TwlERAKEATISMGSAVFAgVAMTNLPGILVLGLAKAQLIQIF 1265
Cdd:COG1033   307 R--EALREALRKLGPPVLL-TSLTTAIGFLSLLFSDIPPIRDF 346
2A067 TIGR00921
The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized ...
 1156-1266 7.32e-04

The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Characterized members of the RND superfamily all probably catalyze substrate efflux via an H+ antiport mechanism. These proteins are found ubiquitously in bacteria, archaea and eukaryotes. They fall into seven phylogenetic families, this family (2.A.6.7) consists of uncharacterised putative transporters, largely in the Archaea. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273340 [Multi-domain]  Cd Length: 719  Bit Score: 44.06  E-value: 7.32e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231351  1156 LLLGLDLRS---GLLNLLSIVMILVDTVGFMALWGISYNAVSLINLVSAVGMSVEFVSHITRSF------------AIST 1220
Cdd:TIGR00921  208 LVLLLDFKRwwrPLLPLVIILFGVAWVLGIMGWLGIPLYATTLLAVPMLIGVGIDYGIQTLNRYeeerdigrakgeAIVT 287

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 156231351  1221 KPTWLERAKEATISMGSAVFAGVAMTNLPGI------LVLGLAKAQLIQIFF 1266
Cdd:TIGR00921  288 AVRRTGRAVLIALLTTSAGFAALALSEFPMVsefglgLVAGLITAYLLTLLV 339
YdfJ COG2409
Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function ...
 288-415 1.61e-03

Predicted lipid transporter YdfJ, MMPL/SSD domain, RND superfamily [General function prediction only];


Pssm-ID: 441964 [Multi-domain]  Cd Length: 697  Bit Score: 42.83  E-value: 1.61e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156231351  288 IIILCSVFAVVTIL-----LVGFRV-APARDKSKMVDPKKGTslsdklsfsthtllgqFFQGWGTWVASWPLTILVLSVI 361
Cdd:COG2409   306 IGVAVAVLAALTLLpallaLLGRRVfWPRRPRRRRAAAPESG----------------FWRRLARAVVRRPVPVLVAAVA 369

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 156231351  362 PVVALAAGLVFTELTTDPVELWSAPNSQARSEKAFhDQHFGPFFrTNQVILTAP 415
Cdd:COG2409   370 VLLALALPALGLRLGLPDADSLPADSPSRQGYDAL-AEHFPPGS-NGPLTVVVE 421
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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