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Conserved domains on  [gi|28373101|ref|NP_037437|]
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alpha-2,8-sialyltransferase 8E isoform 2 [Homo sapiens]

Protein Classification

glycosyltransferase family 29 protein( domain architecture ID 10466376)

glycosyltransferase family 29 protein catalyzes the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds; uses a nucleotide monophosphosugar as the donor instead of a nucleotide diphosphosugar

CATH:  3.90.1480.20
CAZY:  GT29
EC:  2.4.-.-
Gene Ontology:  GO:0006486|GO:0008373
PubMed:  9334165

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GT29_ST8SIA5 cd23990
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2, ...
 98-370 0e+00

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5 (also known as alpha-2,8-sialyltransferase 8E) is involved in the biosynthesis of gangliosides, such as GD1c, GT1a, GQ1b, and GT3. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


:

Pssm-ID: 467718  Cd Length: 273  Bit Score: 588.34  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373101  98 SEANQFKSTLSRCCNAPAFLFTTQKNTPLGTKLKYEVDTSGIYHINQEIFRMFPKDMPYYRSQFKKCAVVGNGGILKNSR 177
Cdd:cd23990   1 TEANAFKSSLSRCCNAPSFLFTTQKNTPLGTKLKYEVDTSGIYHINSEIFKMFPKDMPYSRSQFKKCAVVGNGGILKNSK 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373101 178 CGREINSADFVFRCNLPPISEKYTMDVGVKTDVVTVNPSIITERFHKLEKWRRPFYRVLQVYENASVLLPAFYNTRNTDV 257
Cdd:cd23990  81 CGREIDSADFVFRCNLPPISEKYVRDVGVKTDVVTINPSIITERFHKLEKWRRPFYEVLQVYENASVVLPAFYNTRNTDV 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373101 258 SIRVKYVLDDFESPQAVYYFHPQYLVNVSRYWLSLGVRAKRISTGLILVTAALELCEEVHLFGFWAFPMNPSGLYITHHY 337
Cdd:cd23990 161 SIRVKYVLDDFESQQAVYYFHPQYLLNVSRFWLRQGVRAKRISSGLMLVTAALELCEEVHLYGFWAFPMNPSGIFITHHY 240

                       250       260       270
                ....*....|....*....|....*....|...
gi 28373101 338 YDNVKPRPGFHAMPSEIFNFLHLHSRGILRVHT 370
Cdd:cd23990 241 YDNVKPRPGFHAMPSEIFNFLHMHSRGILRVHT 273
 
Name Accession Description Interval E-value
GT29_ST8SIA5 cd23990
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2, ...
 98-370 0e+00

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5 (also known as alpha-2,8-sialyltransferase 8E) is involved in the biosynthesis of gangliosides, such as GD1c, GT1a, GQ1b, and GT3. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467718  Cd Length: 273  Bit Score: 588.34  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373101  98 SEANQFKSTLSRCCNAPAFLFTTQKNTPLGTKLKYEVDTSGIYHINQEIFRMFPKDMPYYRSQFKKCAVVGNGGILKNSR 177
Cdd:cd23990   1 TEANAFKSSLSRCCNAPSFLFTTQKNTPLGTKLKYEVDTSGIYHINSEIFKMFPKDMPYSRSQFKKCAVVGNGGILKNSK 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373101 178 CGREINSADFVFRCNLPPISEKYTMDVGVKTDVVTVNPSIITERFHKLEKWRRPFYRVLQVYENASVLLPAFYNTRNTDV 257
Cdd:cd23990  81 CGREIDSADFVFRCNLPPISEKYVRDVGVKTDVVTINPSIITERFHKLEKWRRPFYEVLQVYENASVVLPAFYNTRNTDV 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373101 258 SIRVKYVLDDFESPQAVYYFHPQYLVNVSRYWLSLGVRAKRISTGLILVTAALELCEEVHLFGFWAFPMNPSGLYITHHY 337
Cdd:cd23990 161 SIRVKYVLDDFESQQAVYYFHPQYLLNVSRFWLRQGVRAKRISSGLMLVTAALELCEEVHLYGFWAFPMNPSGIFITHHY 240

                       250       260       270
                ....*....|....*....|....*....|...
gi 28373101 338 YDNVKPRPGFHAMPSEIFNFLHLHSRGILRVHT 370
Cdd:cd23990 241 YDNVKPRPGFHAMPSEIFNFLHMHSRGILRVHT 273
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 118-365 4.13e-91

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 274.10  E-value: 4.13e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373101   118 FTTQKNTPLGTKLKYEvDTSGIYHINQEIFRMFPKDMPYYRSQFKKCAVVGNGGILKNSRCGREINSADFVFRCNLPPIs 197
Cdd:pfam00777   1 FLTKENFPLGEWIRYS-EWWLPFTVTEELLELLPKVSPFDNKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPT- 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373101   198 EKYTMDVGVKTDVVTVNP-SIITERFHKL--EKWRRPFYRVLQVYE--NASVLLPAFYNTRNTDVSIRVKYVLDDFESPQ 272
Cdd:pfam00777  79 KGYEKDVGSKTTLRTMNPeSAIDSKYGNLgfSHPRDPFVEFVLVPFkgRDLLWLPAFLTKGNVSRSLRVLYTLKEVKIPV 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373101   273 A---VYYFHPQYLVNVSRYWL-SLGVRAKRISTGLILVTAALELCEEVHLFGFWAFPMNPsglYITHHYYDNVKPRP--- 345
Cdd:pfam00777 159 DpdkVLFLHPDFLRYVANFWLrSHGLKGRRPSTGLLMLSLALHLCDEVSLYGFGPFLDSR---GNSHHYYDNVLMKKggf 235

                         250       260
                  ....*....|....*....|.
gi 28373101   346 -GFHAMPSEIFNFLHLHSRGI 365
Cdd:pfam00777 236 yGVHDMPFEFKLLQKLHKEGV 256
 
Name Accession Description Interval E-value
GT29_ST8SIA5 cd23990
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2, ...
 98-370 0e+00

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5 (also known as alpha-2,8-sialyltransferase 8E) is involved in the biosynthesis of gangliosides, such as GD1c, GT1a, GQ1b, and GT3. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467718  Cd Length: 273  Bit Score: 588.34  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373101  98 SEANQFKSTLSRCCNAPAFLFTTQKNTPLGTKLKYEVDTSGIYHINQEIFRMFPKDMPYYRSQFKKCAVVGNGGILKNSR 177
Cdd:cd23990   1 TEANAFKSSLSRCCNAPSFLFTTQKNTPLGTKLKYEVDTSGIYHINSEIFKMFPKDMPYSRSQFKKCAVVGNGGILKNSK 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373101 178 CGREINSADFVFRCNLPPISEKYTMDVGVKTDVVTVNPSIITERFHKLEKWRRPFYRVLQVYENASVLLPAFYNTRNTDV 257
Cdd:cd23990  81 CGREIDSADFVFRCNLPPISEKYVRDVGVKTDVVTINPSIITERFHKLEKWRRPFYEVLQVYENASVVLPAFYNTRNTDV 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373101 258 SIRVKYVLDDFESPQAVYYFHPQYLVNVSRYWLSLGVRAKRISTGLILVTAALELCEEVHLFGFWAFPMNPSGLYITHHY 337
Cdd:cd23990 161 SIRVKYVLDDFESQQAVYYFHPQYLLNVSRFWLRQGVRAKRISSGLMLVTAALELCEEVHLYGFWAFPMNPSGIFITHHY 240

                       250       260       270
                ....*....|....*....|....*....|...
gi 28373101 338 YDNVKPRPGFHAMPSEIFNFLHLHSRGILRVHT 370
Cdd:cd23990 241 YDNVKPRPGFHAMPSEIFNFLHMHSRGILRVHT 273
GT29_ST8SIA_mono cd23971
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are ...
 98-370 2.47e-172

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on theircatalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467699  Cd Length: 271  Bit Score: 480.99  E-value: 2.47e-172
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373101  98 SEANQFKSTLSRCCNAPAFLFTTQKNTPLGTKLKYEVDTSGIYHINQEIFRMFPKDMPYYRSQFKKCAVVGNGGILKNSR 177
Cdd:cd23971   1 TEHQQFRSELRSCCNASHELVVTQENTPLGSKIHYEGERKKTITVNEKLFSMLPKESPFSNKPLKTCAVVGNGGILKNSS 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373101 178 CGREINSADFVFRCNLPPISekYTMDVGVKTDVVTVNPSIITERFHKLEKWRRPFYRVLQVYENASVLLPAFYNTRNTDV 257
Cdd:cd23971  81 CGREIDSADFVIRCNLPPLN--DSKDVGSKTNLVTANPSILREKFHNLKKRRRPFVERMKVYGNALLLLPAFSYTSNTEP 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373101 258 SIRVKYVLDDFESPQAVYYFHPQYLVNVSRYWLSLGVRAKRISTGLILVTAALELCEEVHLFGFWAFPMNPSGLYITHHY 337
Cdd:cd23971 159 SLRALYTLEDFGSPQKVLFFNPEYLRNLSRYWKSKGLKARRLSTGLMLVSAALELCENVHLYGFWPFSTDLDGNPISHHY 238

                       250       260       270
                ....*....|....*....|....*....|...
gi 28373101 338 YDNVKPRPGFHAMPSEIFNFLHLHSRGILRVHT 370
Cdd:cd23971 239 YDNVLPKKGVHAMPEEFLRYLKLHSQGVLRLHL 271
GT29_ST8SIA6 cd23991
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2, ...
 99-368 6.33e-124

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6 (also known as alpha-2,8-sialyltransferase 8F) prefers O-glycans to N-glycans or glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29(GT29).


Pssm-ID: 467719  Cd Length: 273  Bit Score: 358.30  E-value: 6.33e-124
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373101  99 EANQFKSTLSRCCNAPAFLFTTQKNTPLGTKLKYEVDTSGIYHINQEIFRMFPKDMPYYRSQFKKCAVVGNGGILKNSRC 178
Cdd:cd23991   2 EHENFRSELSSCCNAVQNFIVSQNNTPLGTNLTYEVEPKKKILITENIFRMFPKSQPFRGYPYKQCAVVGNGGILKNSSC 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373101 179 GREINSADFVFRCNLPPISEKYTMDVGVKTDVVTVNPSIITERFHKLEKWRRPFYRVLQVYENASVLLPAFYNTRNTDVS 258
Cdd:cd23991  82 GAEIDQADFVFRCNLPPTGGNISKDVGSKTNLVTANPSIISIKYAKLNERRKPFLETVSVYGDAFLLLPAFSYRSNTALS 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373101 259 IRVKYVLDDFESPQAVYYFHPQYLVNVSRYWLSLGVRAKRISTGLILVTAALELCEEVHLFGFWAFPMNPSGLYITHHYY 338
Cdd:cd23991 162 FKVYYTLEDFKAKQKVIFFHPIYLKHLAQFWRSKGVQVYRLSTGLMITSAALELCEEVKLYGFWPFSKNTEGKPISHHYY 241

                       250       260       270
                ....*....|....*....|....*....|
gi 28373101 339 DNVKPRPGFHAMPSEIFNFLHLHSRGILRV 368
Cdd:cd23991 242 DNQLPKPGFHSMPKEFYQLLQLHSKGILKL 271
GT29_ST8SIA1 cd23989
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2, ...
 103-369 9.67e-105

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1 (also known as ganglioside GD3 synthase) adds sialic acids to GM3 ganglioside. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze analpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467717  Cd Length: 272  Bit Score: 309.45  E-value: 9.67e-105
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373101 103 FKSTLSRCCNAPAFLFTTQKNTPLGTKLKYEVDTSGIYHINQEIFRMFPKDMPYYRsQFKKCAVVGNGGILKNSRCGREI 182
Cdd:cd23989   6 FRKLLEDCCDPKRLFAVTKHNSPLGKNLWFDGEFLHSHTVDNETYSLFPQDTPLQL-PLKKCSVVGNGGILKNSGCGQQI 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373101 183 NSADFVFRCNLPPISEKYTMDVGVKTDVVTVNPSIITERFHKLEKWRRPFYRVLQVYENASVLLPAFYNTRNTDVSIRVK 262
Cdd:cd23989  85 DRADFVMRCNLPPLSREYTDDVGTKTQLVTANPSIIDKRFQNLLWSRKSFVESMKVYGRSYIYMPAFSMKTGTDPSLRVY 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373101 263 YVLDDFESPQAVYYFHPQYLVNVSRYWLSLGVRAKRISTGLILVTAALELCEEVHLFGFWAFPMNPSGLYITHHYYDNVK 342
Cdd:cd23989 165 YTLADVGANQTVLFANPNFLRNVGKFWKSKGVHAKRLSTGLFLVSAALGLCEEVTIYGFWPFSVDLDERTISHHYYDNVL 244

                       250       260
                ....*....|....*....|....*..
gi 28373101 343 PRPGFHAMPSEIFNFLHLHSRGILRVH 369
Cdd:cd23989 245 PDSGFHAMPEEFLQLWHLHKSGVLRMQ 271
GT29_ST8SIA cd23963
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are ...
 100-370 5.02e-95

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on their catalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467691  Cd Length: 274  Bit Score: 284.54  E-value: 5.02e-95
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373101 100 ANQFKSTLSRCCNaPAFLFTTQKNTPLGTKLKYEVDTSGIYHINQEIFRMFPKDMPYYRSQFKKCAVVGNGGILKNSRCG 179
Cdd:cd23963   3 LDKFRKELERLLN-TRKLFLTQKNTPLGDVLYYSYFKKKTFKITKSLYELLPKTSPFSHKRYKTCAVVGNSGILLGSGCG 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373101 180 REINSADFVFRCNLPPIsEKYTMDVGVKTDVVTVNPSIITERFHKL--EKWRRPFYRVLQVYENASVLLPAFYNTRNTDV 257
Cdd:cd23963  82 KEIDSHDFVIRCNLPPI-KGFEKDVGRKTNLTTLNPSILKRRYNSLkkNRDRDKFLNRLKEYNGSILWYPKFSFKSSTNL 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373101 258 SIRVKYVLDDFESPQAVYYFHPQYLVNVSRYWLSLGVRaKRISTGLILVTAALELCEEVHLFGFWAFPMNPSGLYITHHY 337
Cdd:cd23963 161 LLKAARALKKNGLNLTVVYSNPEHFLAVQKFWKRRGLE-KRPSTGLYLVSLALTFCDEIHLYGFWPFPTDPNGRPVPYHY 239

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 28373101 338 YDNVKPRP--GFHAMPSEiFNFLH-LHSRGILRVHT 370
Cdd:cd23963 240 YDDLSPSTknKVHNMPEE-FKLLReLHKKGVLKLHT 274
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 118-365 4.13e-91

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 274.10  E-value: 4.13e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373101   118 FTTQKNTPLGTKLKYEvDTSGIYHINQEIFRMFPKDMPYYRSQFKKCAVVGNGGILKNSRCGREINSADFVFRCNLPPIs 197
Cdd:pfam00777   1 FLTKENFPLGEWIRYS-EWWLPFTVTEELLELLPKVSPFDNKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPT- 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373101   198 EKYTMDVGVKTDVVTVNP-SIITERFHKL--EKWRRPFYRVLQVYE--NASVLLPAFYNTRNTDVSIRVKYVLDDFESPQ 272
Cdd:pfam00777  79 KGYEKDVGSKTTLRTMNPeSAIDSKYGNLgfSHPRDPFVEFVLVPFkgRDLLWLPAFLTKGNVSRSLRVLYTLKEVKIPV 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373101   273 A---VYYFHPQYLVNVSRYWL-SLGVRAKRISTGLILVTAALELCEEVHLFGFWAFPMNPsglYITHHYYDNVKPRP--- 345
Cdd:pfam00777 159 DpdkVLFLHPDFLRYVANFWLrSHGLKGRRPSTGLLMLSLALHLCDEVSLYGFGPFLDSR---GNSHHYYDNVLMKKggf 235

                         250       260
                  ....*....|....*....|.
gi 28373101   346 -GFHAMPSEIFNFLHLHSRGI 365
Cdd:pfam00777 236 yGVHDMPFEFKLLQKLHKEGV 256
GT29_ST8SIA_poly cd23969
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be ...
 127-370 1.23e-61

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be polysialyltransferases, and they can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467697  Cd Length: 276  Bit Score: 199.18  E-value: 1.23e-61
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373101 127 GTKLKYEVDTSGIYHINQEIFRMFPKDMPYYRSQFKKCAVVGNGGILKNSRCGREINSADFVFRCNLPPIsEKYTMDVGV 206
Cdd:cd23969  30 GDRMHYEIDRHKTVNITQDLYQLLPEVSPLKGKHFRTCAVVGNSGILLNSGCGQEIDSHDFVIRCNLAPV-EGYEKDVGT 108

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373101 207 KTDVVTVNPSIITERFHKL--EKWRRPFYRVLQVYENASVLLPAFYNTRNTDvsiRVKYVLD---DFESPQAVYYFHPQY 281
Cdd:cd23969 109 KSNLTTMNPSVIPHAYGDLvnATDKEKFVERLRQLGDSILWIPAFVSKGGEE---HVQWTNEiilKHKLNVKTAYPPLRL 185

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373101 282 LVNVSRYWLSLGVRAKRISTGLILVTAALELCEEVHLFGFWAFPMNPSGLYITHHYYDNVKPR--PGFHAMPSEIFNFLH 359
Cdd:cd23969 186 NHAIRGYWLTTKFRIKRPSTGLLMYTLATRFCDEIHLYGFYPFSEDGNGRAVKYHYYDNRKYLttARPHKMPEEFRALRS 265

                       250
                ....*....|.
gi 28373101 360 LHSRGILRVHT 370
Cdd:cd23969 266 LHQRGALRLHT 276
GT29_ST8SIA3_oligo cd23970
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2, ...
 139-370 2.25e-61

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3 synthesizes polysialic acid and has been shown to autopolysialylate. ST8Sia3 utilizes the Siaalpha2,3Galbeta1,4GlcNAc structure on N-glycans of glycoproteins and glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acidand the terminal sialic acid residues of glycochains, by transfering sialic acidfrom CMP-Sia and they belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467698  Cd Length: 284  Bit Score: 198.77  E-value: 2.25e-61
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373101 139 IYHINQEIFRMFPKDMPYYRSQFKKCAVVGNGGILKNSRCGREINSADFVFRCNLPPIsEKYTMDVGVKTDVVTVNPSII 218
Cdd:cd23970  46 VFSISPNLRSLLPEVSPFQNKHYNTCAVVGNSGILTNSQCGNEIDKSDFVFRCNFAPT-EGFEKDVGRKTNLTTFNPSIL 124

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373101 219 TERFHKL--EKWRRPFYRVLQVYENASVLLPAF-YNTRNTDVSIRVKYVLDDFESPQAVYYFHPQYLVNVSRYWLSLGVR 295
Cdd:cd23970 125 EKYYNNLltIQDRNNFFLSLKKLDGAILWIPAFfFHTSATVTRTLVDFFVEHRGQLKVQLAWPGNIMQHVNRYWKTKHLS 204

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373101 296 AKRISTGLILVTAALELCEEVHLFGFWAFPMNPSGLYITHHYYD------NVKPRPgFHAMPSEIFNFLHLHSRGILRVH 369
Cdd:cd23970 205 PKRLSTGILMYTLASAICEEIHLYGFWPFGFDPTGTPLPYHYYDkkgtkfTTKWQE-SHQLPAEFVLLYKMHGAGVLKLT 283


                .
gi 28373101 370 T 370
Cdd:cd23970 284 L 284
GT29_ST8SIA2 cd23987
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase ...
 127-370 1.67e-56

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia2 catalyzes shorter polysialic acid formation of NCAMs than ST8Sia4. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467715  Cd Length: 278  Bit Score: 186.30  E-value: 1.67e-56
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373101 127 GTKLKYEVDTSGIYHINQEIFRMFPKDMPYYRSQFKKCAVVGNGGILKNSRCGREINSADFVFRCNLPPISEkYTMDVGV 206
Cdd:cd23987  30 GDVIHYVFDRDSTMNISQNLYELLPRTSPLKNKHFKTCAIVGNSGILLNSGCGREIDSHDFVIRCNLAPVEE-YAKDVGT 108

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373101 207 KTDVVTVNPSIITERFHKL--EKWRRPFYRVLQVYENASVLLPAFYNTRNTDvsiRVKYVLD-DFESPQAVYYFHP--QY 281
Cdd:cd23987 109 KTDLVTMNPSVVQRAFEDLvnETWKEKFLQRLQSLNGSILWIPAFMAKGGEE---RVEWVNDlILKHHINVRTAYPslRL 185

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373101 282 LVNVSRYWLSLGVRAKRISTGLILVTAALELCEEVHLFGFWAFPMNPSGLYITHHYYDNVK----PRPGFHAMPSEIFNF 357
Cdd:cd23987 186 LHAVRGYWLTNKVHIKRPTTGLLMYTLATRFCNRIHLYGFWPFPRDQNQNPVKYHYYDSLKygytSQASPHTMPLEFKAL 265

                       250
                ....*....|...
gi 28373101 358 LHLHSRGILRVHT 370
Cdd:cd23987 266 KNLHQQGALKLTV 278
GT29_ST8SIA4 cd23988
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase ...
 127-370 1.55e-51

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia4 catalyzes longer polysialicacid formation of NCAMs than ST8Sia2. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467716  Cd Length: 278  Bit Score: 173.22  E-value: 1.55e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373101 127 GTKLKYEVDTSGIYHINQEIFRMFPKDMPYYRSQFKKCAVVGNGGILKNSRCGREINSADFVFRCNLPPISEkYTMDVGV 206
Cdd:cd23988  30 GDVIHYVLDRRRTLNISQNLHSLLPEVSPMKNRRFKTCAVVGNSGILLDSGCGKEIDSHDFVIRCNLAPVVE-FAADVGT 108

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373101 207 KTDVVTVNPSIITERFHKL--EKWRRPFYRVLQVYENASVLLPAFY-NTRNTDVSIRVKYVLDDFESPQAVYyfhPQY-L 282
Cdd:cd23988 109 KSDFITMNPSVVQRAFGGFrnESDREKFVHRLSMLNDSVLWIPAFMvKGGEKHVEWVNALILKNKLKVRTAY---PSLrL 185

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373101 283 VNVSR-YWLSLGVRAKRISTGLILVTAALELCEEVHLFGFWAFPMNPSGLYITHHYYDNVKPR----PGFHAMPSEIFNF 357
Cdd:cd23988 186 IHAVRgYWLTNKVNIKRPSTGLLMYTLATRFCDEIHLYGFWPFPKDANGNPVKYHYYDDLKYRyfsnAGPHRMPLEFKTL 265

                       250
                ....*....|...
gi 28373101 358 LHLHSRGILRVHT 370
Cdd:cd23988 266 NVLHNRGALKLTT 278
GT29 cd19952
glycosyltransferase family 29; Glycosyltransferase family 29 members (also called ...
 164-346 2.24e-29

glycosyltransferase family 29; Glycosyltransferase family 29 members (also called sialyltransferases) are enzymes that transfer sialic acid to oligosaccharide, each having specificity for a certain sugar substrate.


Pssm-ID: 467690  Cd Length: 193  Bit Score: 112.07  E-value: 2.24e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373101 164 CAVVGNGGILKNSRCGREINSADFVFRCNLPPIsEKYTMDVGVKTDVVTVNPSIiterFHKLEKWRRPFYRVLQVYENAS 243
Cdd:cd19952   1 CAVVGNSGILLGSEYGKEIDSHDAVFRFNQAPT-KGFEKDVGSKTTFRVLNSKW----AGFYLRGPRCGCHPLPLEEEVV 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373101 244 VLLPAFYNTRNTDVSIRVKYvlddfeSPQAVYYFH---PQYLVNVSRYWLSLGVRAKRI----STGLILVTAALELCEEV 316
Cdd:cd19952  76 LILSRAAAADFKRLKRRKKR------HDNAVLLLTdpaPDLLSYVRKRLEKLGLKSFFGgnapSSGLLAVLLALQLCDSV 149

                       170       180       190
                ....*....|....*....|....*....|
gi 28373101 317 HLFGFWAFPMNPSGLYitHHYYDNVKPRPG 346
Cdd:cd19952 150 DLYGFGVDSGHAPKVP--YHYYDLVEAEEG 177
GT29_ST6GALNAC1_2 cd23964
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members ...
 163-370 8.62e-20

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 and 2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467692  Cd Length: 292  Bit Score: 88.47  E-value: 8.62e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373101 163 KCAVVGNGGILKNSRCGREINSADFVFRCNLPPISEKYTmDVGVKTD--VVTVNPSIITERFHklekwrrpfyrVLQVYE 240
Cdd:cd23964  84 RCAVVGNGGILNGSGKGKEIDAHDYVFRVNHALTKGFEK-DVGTKTSfyTFFPESLHNSLLKH-----------VPQDKD 151

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373101 241 NASVLLP-----------AFYNTRNTDVSIRVKYVLDDFES---PQAVYYFHPQYLVNVSRYWLslgvRAKRI---STGL 303
Cdd:cd23964 152 TKYLFIPfkirdydyldaVLSGKPVPDGCDKGKRPPPLFGPklnATNVRLLHPDFIRYLFNRWL----NSSTSyrpTTGA 227

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 28373101 304 ILVTAALELCEEVHLFGF---WAFPMnpsglyithHYYDN----VKPRPGFHAMPSEIFNFLHLHSRGILRVHT 370
Cdd:cd23964 228 LMLLTALHTCDQVSVYGFgydPRFSL---------HYYDKtfvkFTVFYANHDFTNERKLWRKLHEEGIINLYR 292
GT29_ST3GAL1_2 cd23966
beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from ...
 144-369 2.72e-19

beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL1 and 2 preferentially utilize the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1O-glycans) and on glycolipids as an acceptor substrate, respectively. Members ofthis family belong to glycosyltransferase family 29.


Pssm-ID: 467694  Cd Length: 276  Bit Score: 86.57  E-value: 2.72e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373101 144 QEIFRMFPKDMPYYR---SQFKKCAVVGNGGILKNSRCGREINSADFVFRCNLPPIsEKYTMDVGVKTdvvtvnpsiiTE 220
Cdd:cd23966  57 EKLFQVVPGENPYRTrdpNRCRRCAVVGNSGNLRGSRYGKLIDSHDFVIRMNKAPT-KGFEKDVGSKT----------TH 125

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373101 221 RFhklekwrrpfyrvlqVY-ENAS--------VLLP-----------AFYNTRNTDVSIRVKYVLDdfESPQAVYYFHPQ 280
Cdd:cd23966 126 HF---------------MYpESAVdldpgvhlVLVPfkvldlqwlisALTTGEITRTYTPVKRFIK--ADKDKVLVINPA 188

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373101 281 YLVNVSRYWLSLgvRAKRISTGLILVTAALELCEEVHLFGFWAfpmNPSGLYitHHYYDNVKPRPGFHAMPSEIFNFLH- 359
Cdd:cd23966 189 FIKYVHDNWTEH--HGRYPSTGFLALIFALHICDEVSVFGFGA---DSKGNW--HHYWEKNRSAGAFRKTGVHDADFESd 261

                       250
                ....*....|....
gi 28373101 360 ----LHSRGILRVH 369
Cdd:cd23966 262 iikkLAKEGKIRVY 275
GT29_ST6GALNAC2L cd23974
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are ...
 148-370 5.53e-19

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467702  Cd Length: 309  Bit Score: 86.34  E-value: 5.53e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373101 148 RMFPKDM-PYYRSQFKKCAVVGNGGILKNSRCGREINSADFVFRCNlPPISEKYTMDVGVKTDVVTVNPSIIterFHKLE 226
Cdd:cd23974  70 QMFDWWDrPNGRSPCIRCAVVGNGGILNGSRMGAEIDGHDYVFRVN-GAITKGFEKDVGRRTSFYTFSTNTL---MNSLR 145

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373101 227 KWRRPFYRVL-QVYENASVLLP-----------AFYNT---RNTDVSIR-VKYVLDDFeSPQAVYYFHP---QYLVNvsR 287
Cdd:cd23974 146 AYAGVGFNGPpQSKETRYIFLPdhdrdyllvkaALTHTpidRGRDKSKRpSKYFGKDV-TAEKFKIYHPdfiRYLRN--R 222

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373101 288 YWLS--LGVRAKRI---STGLILVTAALELCEEVHLFGFwafpMNPSGLYITHHYYDNVKPRPGF---HAMPSEIFNFLH 359
Cdd:cd23974 223 FLWSpiLNTKQRDIyrpSTGAVMLLAALHTCDQVSAYGF----MTPDYGKYSDHYYDKTYHKVVFyanHDLRLEMQLWQK 298

                       250
                ....*....|.
gi 28373101 360 LHSRGILRVHT 370
Cdd:cd23974 299 LHKAGLIKLYM 309
GT29_ST3GAL3_4_5_6 cd23967
beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid ...
 162-359 1.70e-17

beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL3 and 4 utilize bothGalbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates. ST3GAL5 is also known as GM3 ganglioside synthase. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467695  Cd Length: 205  Bit Score: 80.03  E-value: 1.70e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373101 162 KKCAVVGNGGILKNSRCGREINSADFVFRCNLPPIsEKYTMDVGVKTdvvtvnpsiiTERFhklekwrrpfyrvlqVYEN 241
Cdd:cd23967   3 RRCVVVGNGGVLKGKSLGSVIDKYDVVIRMNDAPV-KGYEKDVGSKT----------TFRM---------------FYPE 56

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373101 242 ASVLLPAFYNtRNTDVSIrVKYVLDDFESPQAVYY---------------------------FHPQYLVNVSRYWLSL-- 292
Cdd:cd23967  57 SAFRDPEEYD-SDWLLVL-VPFKSMDLLWLQAVIKgkkpngkggfwkkiatsvpkppkkiriLNPYILQEAAFDLIGLpm 134

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 28373101 293 --GVRAKRISTGLILVTAALELCEEVHLFGFWAFPMNPSglyITHHYYDNVKprpgfhaMPSEIFNFLH 359
Cdd:cd23967 135 ngKQGKNVPTTGIIAIVMALHYCDEVDIAGFGYDPSDPN---APLHYYDSLT-------MKAIKRSWTH 193
GT29_ST6GAL1_2 cd23968
beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are ...
 115-342 5.29e-16

beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are beta-galactosidealpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the terminal galactose residue of a glycochain, by transfering sialic acid fromCMP-Sia. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467696  Cd Length: 266  Bit Score: 76.93  E-value: 5.29e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373101 115 AFLFTTQKNTPLGTKLKYevdtSGIYHINQEIFRMFPKdmpyyrsqFKKCAVVGNGGILKNSRCGREINSADFVFRCNLP 194
Cdd:cd23968  11 AAPFSTLRKTTSPFKDLL----SLRYPFPESSLENTKR--------YNTCAVVSSSGALLGSKLGKEIDSHDAVLRFNDA 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373101 195 PiSEKYTMDVGVKTDVVTVNPSIITERFHKLekWRRPFYRvlqvyeNASVLL--PAFYNTRNTDVSIRVKYvlDDFES-- 270
Cdd:cd23968  79 P-TKGFEKDVGSKTTLRLINSQILSKPEFNF--LTDPLYR------NVTLLVwdPSSYNVNLEKWYKKPDF--DFFPNyi 147

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373101 271 ------P-QAVYYFHPQYLVNVsryWLSLGVRAKRI------STGLILVTAALELCEEVHLFGFWafpmnPSgLYITH-- 335
Cdd:cd23968 148 kyrrrhPeEPFYLIDPRFLWRL---WDILQEYTPEKikpnppSSGFIGIVLMLHLCDWVDVYEYV-----PS-VRQTDrc 218


                ....*..
gi 28373101 336 HYYDNVK 342
Cdd:cd23968 219 HYYDVEK 225
GT29_ST3GAL1 cd23980
beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from ...
 129-340 8.69e-16

beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL1 preferentially utilizes the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1 O-glycans) as an acceptor substrate. Members of this family belong to glycosyltransferase family29 (GT29).


Pssm-ID: 467708  Cd Length: 280  Bit Score: 76.84  E-value: 8.69e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373101 129 KLKYEVDTSGIYHINQEIFRMFPKD---MPYYRS-QFKKCAVVGNGGILKNSRCGREINSADFVFRCNLPPiSEKYTMDV 204
Cdd:cd23980  45 RLQREKKPKNLNDTIRELFQVVPGNvdpLLEKRLvSCRRCAVVGNSGNLKESYYGPQIDSHDFVLRMNKAP-TEGFEADV 123

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373101 205 GVKTDVVTVNPSIITERFHKLEKWRRPFyRVLQVYENASVLLPAFYNTRNTDVSIRVKYvlddfeSPQAVYYFHPQYLVN 284
Cdd:cd23980 124 GSKTTHHFVYPESFRELAQNVSMILVPF-KTLDLEWVISATTTGTISHTYVPVPRKIKV------KKEKILIYHPAFIKY 196

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 28373101 285 VSRYWLSLGVRAKriSTGLILVTAALELCEEVHLFGFWAfpmNPSGLYitHHYYDN 340
Cdd:cd23980 197 VFDRWLQGHGRYP--STGILSVIFSLHVCDEVDLYGFGA---DSKGNW--HHYWEN 245
GT29_ST6GALNAC2 cd23972
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are ...
 163-369 1.31e-15

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467700  Cd Length: 308  Bit Score: 76.79  E-value: 1.31e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373101 163 KCAVVGNGGILKNSRCGREINSADFVFRCNlPPISEKYTMDVGVKTDV--VTVNpsiiTERFHKLEKWRRPFYRVLQVYE 240
Cdd:cd23972  84 RCAVVGNGGILNGSRQGRAIDAHDYVFRLN-GAVIKGFEEDVGTKTSFygFTVN----TMKNSLISYWNLGFTRTPQGQD 158

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373101 241 NASVLLPA----FYNTRNTDVSIRVKYVLDDFESPQAvyYF------------HPQYLvnvsRYWLSLGVRAKRI----- 299
Cdd:cd23972 159 LQYIFIPSdirdYVMLRSAILGVPVPEGLDKGDRPHK--YFgpeasakkfkllHPDFI----SYLTDRFLKSKLLnthyg 232

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373101 300 -----STGLILVTAALELCEEVHLFGF-----WAFpmnpsglyiTHHYYDNVKPRPGF---HAMPSEIFNFLHLHSRGIL 366
Cdd:cd23972 233 hlympSTGALMLLTALHTCDQVSAYGFitsnyWKF---------SDHYYERKKKPLVFyanHDMLLEAALWRRLHKAGIL 303


                ...
gi 28373101 367 RVH 369
Cdd:cd23972 304 QLY 306
GT29_ST6GALNAC1 cd23973
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are ...
 163-371 1.18e-14

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467701  Cd Length: 309  Bit Score: 74.02  E-value: 1.18e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373101 163 KCAVVGNGGILKNSRCGREINSADFVFRCNLPPIsEKYTMDVGVKTDVVTVNPSIITERFHKLEKwrRPFYRVLQVYENA 242
Cdd:cd23973  85 RCAVVGNGGILNGSKMGQEIDSHDYVFRVNGAVI-KGYEEDVGTRTSFYVHTAHSITSSLMILQK--RGFKNIPQDKDIK 161

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373101 243 SVLLPAF---YN-----TRNTDVSIRV-------KYVLDDFeSPQAVYYFHPQYLvnvsRYWLSLGVRAK---------- 297
Cdd:cd23973 162 YILFPEGprdYQwlealLKNKTIPSGAyygrrprSYFSGDF-TEDKYLVLHPDFL----RYVKNRFLRSKtlkgkywaiy 236

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 28373101 298 RISTGLILVTAALELCEEVHLFGFwafpMNPSGLYITHHYYDNVKPRPGF---HAMPSEIFNFLHLHSRGILRVHTG 371
Cdd:cd23973 237 RPTTGAFLLLTALHLCDTVSAYGF----ITEDYRKYPDHYYDKKKTKLVFyinHDFRLEKKLWKRLHDEKIIKLYQR 309
GT29_ST3GAL6 cd23984
beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from ...
 162-341 5.65e-13

beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467712  Cd Length: 206  Bit Score: 67.08  E-value: 5.65e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373101 162 KKCAVVGNGGILKNSRCGREINSADFVFRCNLPPISeKYTMDVGVKT-------DVVTVNPS---------IITERFHKL 225
Cdd:cd23984   3 KKCVVVGNGGVLRNKSLGKKIDSYDVIIRMNNGPVI-GYENDVGKRTtfrlcypESIFSDPShydpnttvvLIPFKPHDL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373101 226 eKWrrpfyrVLQVYENASVLLPAFYNtrntdvsirvKYVLDDFESPQAVYYFHPQYLVNVSRYWLSLGVR------AKRI 299
Cdd:cd23984  82 -RW------LLDLLMGKKVSAKGFWK----------KPALNLIYKPNQIRILNPFILRIAAYELLHFPKRfpkekkPKHP 144

                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 28373101 300 STGLILVTAALELCEEVHLFGfwaFPMNPSGLYITHHYYDNV 341
Cdd:cd23984 145 TTGIIAITLALHICNEVHIAG---FKYDFSNLNSTLHYYGNE 183
GT29_ST6GAL1 cd23985
beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside ...
 160-321 8.28e-13

beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by transfering sialic acid from CMP-Sia. ST6Gal1 play important roles in the immune system. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467713  Cd Length: 266  Bit Score: 67.81  E-value: 8.28e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373101 160 QFKKCAVVGNGGILKNSRCGREINSADFVFRCNLPPISeKYTMDVGVKTDVVTVNPSIITERFHKLEKwrRPFYR--VLQ 237
Cdd:cd23985  44 PLGRCAVVSSAGSLKSSGLGREIDSHDAVLRFNGAPTA-GFQQDVGTKTTIRLINSQLVTTEKHKFLK--DSLYNegILI 120

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373101 238 VYEnasvllPAFYNT------RNTDVSIrvkyvlddFESPQAVYYFHPQ---YLVNVSRYW----LSLGVRAKRI----- 299
Cdd:cd23985 121 VWD------PAPYHSdipewyKNPDYNF--------FENYKTYRRLNPNqpfYILHPQMQWelwdIIQENSPEEIqpnpp 186

                       170       180
                ....*....|....*....|..
gi 28373101 300 STGLILVTAALELCEEVHLFGF 321
Cdd:cd23985 187 SSGMLGIILMMTLCDQVDVYEF 208
GT29_ST3GAL4 cd23982
beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from ...
 162-359 1.27e-12

beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL4 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,4GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467710  Cd Length: 204  Bit Score: 66.23  E-value: 1.27e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373101 162 KKCAVVGNGGILKNSRCGREINSADFVFRCNLPPISEkYTMDVGVKTDVvtvnpsiiterfhklekwrRPFY----RVLQ 237
Cdd:cd23982   3 RRCVVVGNGHNLKNSSLGDVIDSYDVVIRLNDAPVRG-FEKDVGSKTTI-------------------RLFYpesaQFDP 62

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373101 238 VYENAS----VLLP----AFY--------NTRNTDVSIRVKYVLDDFEsPQAVYYFHPQYLVNVSRYWLSLGVRAKRI-- 299
Cdd:cd23982  63 GIENDPdtllVLVPfkplDFYwlyeilsnEKRVRKGFWKQPPRIWDAN-PKQIRILNPYYTYVAATKLLQVPGQRKKKqk 141

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 28373101 300 -STGLILVTAALELCEEVHLFGFwAFPMNPSGlYITHHYYDNVKPRpgfhAMPSEIFNFLH 359
Cdd:cd23982 142 pTTGLLAITLALHLCDEVHIAGF-GYPDNGNS-NQPIHYYNQITLK----SMANSGHNLNA 196
GT29_ST6GAL2 cd23986
beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside ...
 157-321 3.94e-12

beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside alpha-2,3-sialyltransferases that catalyze an alpha2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by a transfering sialic acid from CMP-Sia. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467714  Cd Length: 270  Bit Score: 66.01  E-value: 3.94e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373101 157 YRSQFKKCAVVGNGGILKNSRCGREINSADFVFRCNLPPiSEKYTMDVGVKTDVVTVNPSIITERFHKLEkwRRPFYR-- 234
Cdd:cd23986  45 HLRGFRSCAVVTSAGAILNSSLGKEIDSHDAVLRFNSAP-TRGYEKDVGNKTTIRIINSQILTNPNHHFI--DSSLYKdv 121

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373101 235 VLQVYENA--SVLLPAFYNtrNTDVSIRVKYVLDDFESP-QAVYYFHPQY---LVNVSRYWLSLGVRAKRISTGLILVTA 308
Cdd:cd23986 122 ILVAWDPApySANLHKWYK--KPDYNLFTPYVQYRKRNPnQPFYILHPKFiwqLWDIIQENTQEKIQPNPPSSGFIGILI 199

                       170
                ....*....|...
gi 28373101 309 ALELCEEVHLFGF 321
Cdd:cd23986 200 MMSMCREVHVYEY 212
GT29_ST3GAL3 cd23981
beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from ...
 162-342 3.82e-10

beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL3 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,3GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467709  Cd Length: 207  Bit Score: 59.17  E-value: 3.82e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373101 162 KKCAVVGNGGILKNSRCGREINSADFVFRCNLPPIsEKYTMDVGVKTDVVTVNPSIITERFHKLE----------KWRRP 231
Cdd:cd23981   3 RRCIIVGNGGVLANKSLGSKIDDYDVVVRLNSAPV-KGFEKDVGSKTTLRITYPEGAIQKPEQYEkdslfvlagfKWQDF 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373101 232 FYRVLQVYENASVLLPAFYNTrntdVSIRVKyvlddfESPQAVYYFHPQYLVNVSRYWLSLGV------RAKRISTGLIL 305
Cdd:cd23981  82 KWLKYIVYKEKVSASDGFWKS----VATRVP------REPHEIRILNPYFIQEAAFSFIGLPFnnglmgRGNIPTLGSVA 151

                       170       180       190
                ....*....|....*....|....*....|....*..
gi 28373101 306 VTAALELCEEVHLFGFwAFPMNPSglYITHHYYDNVK 342
Cdd:cd23981 152 ITMALHNCDEVAVAGF-GYDMNTP--NAPLHYYETIK 185
GT29_ST3GAL2 cd23979
beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from ...
 130-340 7.97e-10

beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL2 preferentially utilizes the Galbeta1,3GalNAc on glycolipids as an acceptor substrate. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467707  Cd Length: 279  Bit Score: 59.11  E-value: 7.97e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373101 130 LKYEVDTSGIYHINQEIFRMFPKDMPYY---RSQFKKCAVVGNGGILKNSRCGREINSADFVFRCNLPPiSEKYTMDVGV 206
Cdd:cd23979  46 LQPQFKPHNTKEVLSKLFQIIPGENPYRswdPSRCRRCAVVGNSGNLRGSGYGKDIDGHDFIMRMNQAP-TVGFEADVGS 124

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373101 207 KTDVVTVNPSIITERFHKLEKWRRPFyRVLQVYENASVLLPAFYNTRNTDVS--IRVKYVLDDFESPQAVYYFHPQYLVN 284
Cdd:cd23979 125 RTTHHFMYPESAKNLPANVSFVLVPF-KTLDLLWITSALSTGQIRFTYAPVKqfLRVDKDKVQIYNPAFFKYIHDRWTEH 203

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 28373101 285 VSRYwlslgvrakrISTGLILVTAALELCEEVHLFGFWAfpmNPSGLYitHHYYDN 340
Cdd:cd23979 204 HGRY----------PSTGMLVLFFALHVCDEVNVYGFGA---DSRGNW--HHYWEN 244
GT29_ST6GALNAC3_4_5_6 cd23965
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family ...
 162-339 3.08e-09

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, bytransfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substratespecificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467693  Cd Length: 225  Bit Score: 56.48  E-value: 3.08e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373101 162 KKCAVVGNGGILKNSRCGREINSADFVFRCNLPPIsEKYTMDVGVKTDV-VTVNPSI--ITERFHKLEKWRRPFYRVLqv 238
Cdd:cd23965   2 DTCALVSSSGQLLGSGAGKEIDSADCVIRMNDAPT-RGYEKDVGRRTTIrVVSHSSLprLLRNAILLLAGTRAPTVVV-- 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373101 239 yenasVLLPafYNTRNTDVSIRVKYVLDDFES-PQAVYYFHPQYLVN-----------VSRY----WLslgvrakriSTG 302
Cdd:cd23965  79 -----FWGP--ETKMNKDGAGKYNLLRSLSKKyPDVEFYSLTPEKMDyadelfeketgKSRIksgtWL---------STG 142

                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 28373101 303 LILVTAALELCEEVHLFG-----FWAFPMNPSGLYithHYYD 339
Cdd:cd23965 143 WFTMLLALDVCDEIKVYGmvpenYCREHPNSKVPY---HYYE 181
GT29_ST3GAL5 cd23983
beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from ...
 162-341 7.83e-08

beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL5 is also known as GM3 ganglioside synthase. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467711  Cd Length: 211  Bit Score: 52.43  E-value: 7.83e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373101 162 KKCAVVGNGGILKNSRCGREINSADFVFRCNLPPIsEKYTMDVGVKTDVVTVNP-------------------------- 215
Cdd:cd23983   3 RRCVVVGSGGILHGLELGHLLDQFDIVIRLNNAPV-QGYSQDVGNKTTIRMTYPegapkseqeydptslfvavlfksvdf 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373101 216 ----SIITERfhKLEKWRRPFYrvLQVYENASVLLPAFYNTRNTDVSIRVKYVLDDFESPQavyyfhpqylvnvSRYWls 291
Cdd:cd23983  82 awlkAMVKKE--PLSFWSRLFF--WKEVADSIPLKPSQFRILNPLIIKETALDILQYPEPQ-------------SRLW-- 142

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|.
gi 28373101 292 lgVRAKRIST-GLILVTAALELCEEVHLFGFwAFPMNPSGLYIthHYYDNV 341
Cdd:cd23983 143 --GWDKNVPTlGVTAVVLATHLCDEVSLAGF-GYDLSQPHAPL--HYYDSV 188
GT29_ST6GALNAC4 cd23977
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are ...
 162-339 3.80e-05

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467705  Cd Length: 228  Bit Score: 44.47  E-value: 3.80e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373101 162 KKCAVVGNGGILKNSRCGREINSADFVFRCNLPPiSEKYTMDVGVKTDVVTVN----PSIITERFHKLEKWRRPFYRVLQ 237
Cdd:cd23977   2 RRCAVVSSSGQMLGSGLGPEIDQQECVLRMNVAP-TAGYEADVGNRSSLRVVShtsvPLLLRNQGYFFQQSRDTKYVIWG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373101 238 VYENASVLLPAfyNTRNTDVSIRVKYvlddfesPQA-VYYFHPQYLVNVSRYWLSLGVRAKR-----ISTGLILVTAALE 311
Cdd:cd23977  81 PERNMDRDGGG--KTYRALLTLAKMY-------PHLqVYTLTEEKMAYCDGVFQNETGKNRMksgsfLSTGWFTMILALE 151

                       170       180       190
                ....*....|....*....|....*....|
gi 28373101 312 LCEEVHLFGFW--AFPMNPSGLYITHHYYD 339
Cdd:cd23977 152 LCEEILVYGMVsdSYCRNKNHSSVPYHYYE 181
GT29_ST6GALNAC3 cd23975
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are ...
 164-339 1.78e-04

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467703  Cd Length: 226  Bit Score: 42.61  E-value: 1.78e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373101 164 CAVVGNGGILKNSRCGREINSADFVFRCNLPPiSEKYTMDVGVKTDVVTVNPSIITERFHKlekwrrPFYRVLQVYENAS 243
Cdd:cd23975   4 CAVVSNSGQMVGQKVGAEIDQSSCIWRMNNAP-TKGYEEDVGKRTTIRVVSHTSVPLLLKN------PDYFFKETNETIY 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373101 244 VLLPAFYNTRNTDVSIRVKYVLDDFES-PQAVYYFHPQYLVNVSRYWLSLGVRAKRISTGLILVTA------ALELCEEV 316
Cdd:cd23975  77 VIWGPFRNMRKDGKGIVYNMLKKAVESyPQAKIYVTTEKRMSYCDTVFKKETGKDRVQSGSYLSTGwftlilAMDACYGI 156

                       170       180
                ....*....|....*....|....*
gi 28373101 317 HLFGFWAFPMNPSGLY--ITHHYYD 339
Cdd:cd23975 157 HVYGMINDTYCKTEGYrkVPYHYYE 181
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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