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Conserved domains on  [gi|6978875|ref|NP_036981|]
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gastrin precursor [Rattus norvegicus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Gastrin super family cl27628
Gastrin/cholecystokinin family;
4-99 3.25e-06

Gastrin/cholecystokinin family;


The actual alignment was detected with superfamily member pfam00918:

Pssm-ID: 474951  Cd Length: 127  Bit Score: 42.45  E-value: 3.25e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6978875      4 LCVCMLVLVLALATFSeaswKPRSQLQDASSG-PRTNGALEQHQLEKLGPASHHRRQLGPQG-----PQHFIADL----- 72
Cdd:pfam00918   3 ICVCVLLAVLSASCLG----QPVSPSHPDGSAvVELEQSLTEHLRHARAAPSSGQLRLLQRLdgnpeQRANLSALlaryi 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 6978875     73 --SKK---QRPPMEEEEEA------------YGWMDFGRRSAEE 99
Cdd:pfam00918  79 qqARKgsfGRNSSAGNLQSldpnhrikdrdyMGWMDFGRRSAEE 122
 
Name Accession Description Interval E-value
Gastrin pfam00918
Gastrin/cholecystokinin family;
4-99 3.25e-06

Gastrin/cholecystokinin family;


Pssm-ID: 459996  Cd Length: 127  Bit Score: 42.45  E-value: 3.25e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6978875      4 LCVCMLVLVLALATFSeaswKPRSQLQDASSG-PRTNGALEQHQLEKLGPASHHRRQLGPQG-----PQHFIADL----- 72
Cdd:pfam00918   3 ICVCVLLAVLSASCLG----QPVSPSHPDGSAvVELEQSLTEHLRHARAAPSSGQLRLLQRLdgnpeQRANLSALlaryi 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 6978875     73 --SKK---QRPPMEEEEEA------------YGWMDFGRRSAEE 99
Cdd:pfam00918  79 qqARKgsfGRNSSAGNLQSldpnhrikdrdyMGWMDFGRRSAEE 122
GASTRIN smart00029
gastrin / cholecystokinin / caerulein family; This family gathers small proteins of about 100 ...
 88-101 5.34e-06

gastrin / cholecystokinin / caerulein family; This family gathers small proteins of about 100 130 amino acids that act as hormones, among them gastrin, cholecystokinin and preprocaerulein which stimulate gastric, biliary, and pancreatic secretion and smooth muscle contraction.


Pssm-ID: 214476  Cd Length: 14  Bit Score: 39.95  E-value: 5.34e-06
                           10
                   ....*....|....
gi 6978875      88 GWMDFGRRSAEEED 101
Cdd:smart00029   1 GWMDFGRRSAEDDD 14
 
Name Accession Description Interval E-value
Gastrin pfam00918
Gastrin/cholecystokinin family;
4-99 3.25e-06

Gastrin/cholecystokinin family;


Pssm-ID: 459996  Cd Length: 127  Bit Score: 42.45  E-value: 3.25e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6978875      4 LCVCMLVLVLALATFSeaswKPRSQLQDASSG-PRTNGALEQHQLEKLGPASHHRRQLGPQG-----PQHFIADL----- 72
Cdd:pfam00918   3 ICVCVLLAVLSASCLG----QPVSPSHPDGSAvVELEQSLTEHLRHARAAPSSGQLRLLQRLdgnpeQRANLSALlaryi 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 6978875     73 --SKK---QRPPMEEEEEA------------YGWMDFGRRSAEE 99
Cdd:pfam00918  79 qqARKgsfGRNSSAGNLQSldpnhrikdrdyMGWMDFGRRSAEE 122
GASTRIN smart00029
gastrin / cholecystokinin / caerulein family; This family gathers small proteins of about 100 ...
 88-101 5.34e-06

gastrin / cholecystokinin / caerulein family; This family gathers small proteins of about 100 130 amino acids that act as hormones, among them gastrin, cholecystokinin and preprocaerulein which stimulate gastric, biliary, and pancreatic secretion and smooth muscle contraction.


Pssm-ID: 214476  Cd Length: 14  Bit Score: 39.95  E-value: 5.34e-06
                           10
                   ....*....|....
gi 6978875      88 GWMDFGRRSAEEED 101
Cdd:smart00029   1 GWMDFGRRSAEDDD 14
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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