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Conserved domains on  [gi|9558759|ref|NP_036581|]
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STEAP1 protein [Homo sapiens]

Protein Classification

ferric reductase-like transmembrane domain-containing protein( domain architecture ID 10484937)

ferric reductase-like transmembrane domain-containing protein such as Steap (Six transmembrane epithelial antigen of the prostate) family proteins that function as metalloreductases, stimulating cellular uptake of both iron and copper

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ferric_reduct pfam01794
Ferric reductase like transmembrane component; This family includes a common region in the ...
 118-264 1.36e-07

Ferric reductase like transmembrane component; This family includes a common region in the transmembrane proteins mammalian cytochrome B-245 heavy chain (gp91-phox), ferric reductase transmembrane component in yeast and respiratory burst oxidase from mouse-ear cress. This may be a family of flavocytochromes capable of moving electrons across the plasma membrane. The Frp1 protein from S. pombe is a ferric reductase component and is required for cell surface ferric reductase activity, mutants in frp1 are deficient in ferric iron uptake. Cytochrome B-245 heavy chain is a FAD-dependent dehydrogenase it is also has electron transferase activity which reduces molecular oxygen to superoxide anion, a precursor in the production of microbicidal oxidants. Mutations in the sequence of cytochrome B-245 heavy chain (gp91-phox) lead to the X-linked chronic granulomatous disease. The bacteriocidal ability of phagocytic cells is reduced and is characterized by the absence of a functional plasma membrane associated NADPH oxidase. The chronic granulomatous disease gene codes for the beta chain of cytochrome B-245 and cytochrome B-245 is missing from patients with the disease.


:

Pssm-ID: 426438 [Multi-domain]  Cd Length: 121  Bit Score: 49.57  E-value: 1.36e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9558759    118 LPMVSITLLALVYLPGVIAAIVQLHNGTKYkkfphwlDKWMLTRKQFGLLSFFFAVLHAIYSLSYPMRRSyrykllnway 197
Cdd:pfam01794   1 LGILALALLPLLLLLALRNNPLEWLTGLSY-------DRLLLFHRWLGRLAFLLALLHVILYLIYWLRFS---------- 63

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 9558759    198 qqvqqnkedAWIEHDVWRMEIYVSLGIVGLAILALLAVTSIPSVSdSLTWREFHYIQSKLGIVSLLL 264
Cdd:pfam01794  64 ---------LEGILDLLLKRPYNILGIIALVLLVLLAITSLPPFR-RLSYELFLYLHILLAVAFLLL 120
 
Name Accession Description Interval E-value
Ferric_reduct pfam01794
Ferric reductase like transmembrane component; This family includes a common region in the ...
 118-264 1.36e-07

Ferric reductase like transmembrane component; This family includes a common region in the transmembrane proteins mammalian cytochrome B-245 heavy chain (gp91-phox), ferric reductase transmembrane component in yeast and respiratory burst oxidase from mouse-ear cress. This may be a family of flavocytochromes capable of moving electrons across the plasma membrane. The Frp1 protein from S. pombe is a ferric reductase component and is required for cell surface ferric reductase activity, mutants in frp1 are deficient in ferric iron uptake. Cytochrome B-245 heavy chain is a FAD-dependent dehydrogenase it is also has electron transferase activity which reduces molecular oxygen to superoxide anion, a precursor in the production of microbicidal oxidants. Mutations in the sequence of cytochrome B-245 heavy chain (gp91-phox) lead to the X-linked chronic granulomatous disease. The bacteriocidal ability of phagocytic cells is reduced and is characterized by the absence of a functional plasma membrane associated NADPH oxidase. The chronic granulomatous disease gene codes for the beta chain of cytochrome B-245 and cytochrome B-245 is missing from patients with the disease.


Pssm-ID: 426438 [Multi-domain]  Cd Length: 121  Bit Score: 49.57  E-value: 1.36e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9558759    118 LPMVSITLLALVYLPGVIAAIVQLHNGTKYkkfphwlDKWMLTRKQFGLLSFFFAVLHAIYSLSYPMRRSyrykllnway 197
Cdd:pfam01794   1 LGILALALLPLLLLLALRNNPLEWLTGLSY-------DRLLLFHRWLGRLAFLLALLHVILYLIYWLRFS---------- 63

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 9558759    198 qqvqqnkedAWIEHDVWRMEIYVSLGIVGLAILALLAVTSIPSVSdSLTWREFHYIQSKLGIVSLLL 264
Cdd:pfam01794  64 ---------LEGILDLLLKRPYNILGIIALVLLVLLAITSLPPFR-RLSYELFLYLHILLAVAFLLL 120
PRK05419 PRK05419
protein-methionine-sulfoxide reductase heme-binding subunit MsrQ;
157-316 4.20e-04

protein-methionine-sulfoxide reductase heme-binding subunit MsrQ;


Pssm-ID: 235452  Cd Length: 205  Bit Score: 41.00  E-value: 4.20e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9558759   157 WMLTRKQFGLLSFFFAVLHAiysLSYpmrrSYRYKLLNWAYqqvqqnkedawiehdVWRmEI----YVSLGIVGLAILAL 232
Cdd:PRK05419  73 LIRTRRLLGLWAFFYATLHL---LSY----LLLDLGLDWSL---------------LGK-EIvkrpYITVGMAAFLILLP 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9558759   233 LAVTSIPSVSDSL--TWREFHyiqsKLGIVSLLLGTIHaliFAWNKWIDIKQfvwytPptfMIAVFLPIVVLIFKSILFL 310
Cdd:PRK05419 130 LALTSTRASQRRLgkRWQKLH----RLVYLIAILAPLH---YLWSVKSDSPE-----P---LIYAAIVAVLLALRLKKLR 194


                 ....*.
gi 9558759   311 PCLRKK 316
Cdd:PRK05419 195 RRWRRL 200
COG4097 COG4097
Predicted ferric reductase [Inorganic ion transport and metabolism];
151-310 1.21e-03

Predicted ferric reductase [Inorganic ion transport and metabolism];


Pssm-ID: 443273 [Multi-domain]  Cd Length: 442  Bit Score: 40.26  E-value: 1.21e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9558759  151 PHWLDKWM-----LTR--KQFGLLSFFFAVLH-AIYSLSYPMRRsyryklLNWAYQQVqqnkEDAWIEHDVWRMEiyvsL 222
Cdd:COG4097  64 PPWLERPFggldrLYRlhKWLGILALVLALAHpLLLLGPKWLVG------WGGLPARL----AALLTLLRGLAEL----L 129

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9558759  223 GIVGLAILALLAVTSIpsVSDSLTWREFHYIQSKLGIVSLLLGTIHALIFAWNKWIDIKQFVWYtppTFMIAVFLPIVVL 302
Cdd:COG4097 130 GEWAFYLLLALVVLSL--LRRRLPYELWRLTHRLLAVAYLLLAFHHLLLGGPFYWSPPAGVLWA---ALAAAGLAAAVYS 204


                ....*...
gi 9558759  303 IFKSILFL 310
Cdd:COG4097 205 RLGRPLRS 212
 
Name Accession Description Interval E-value
Ferric_reduct pfam01794
Ferric reductase like transmembrane component; This family includes a common region in the ...
 118-264 1.36e-07

Ferric reductase like transmembrane component; This family includes a common region in the transmembrane proteins mammalian cytochrome B-245 heavy chain (gp91-phox), ferric reductase transmembrane component in yeast and respiratory burst oxidase from mouse-ear cress. This may be a family of flavocytochromes capable of moving electrons across the plasma membrane. The Frp1 protein from S. pombe is a ferric reductase component and is required for cell surface ferric reductase activity, mutants in frp1 are deficient in ferric iron uptake. Cytochrome B-245 heavy chain is a FAD-dependent dehydrogenase it is also has electron transferase activity which reduces molecular oxygen to superoxide anion, a precursor in the production of microbicidal oxidants. Mutations in the sequence of cytochrome B-245 heavy chain (gp91-phox) lead to the X-linked chronic granulomatous disease. The bacteriocidal ability of phagocytic cells is reduced and is characterized by the absence of a functional plasma membrane associated NADPH oxidase. The chronic granulomatous disease gene codes for the beta chain of cytochrome B-245 and cytochrome B-245 is missing from patients with the disease.


Pssm-ID: 426438 [Multi-domain]  Cd Length: 121  Bit Score: 49.57  E-value: 1.36e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9558759    118 LPMVSITLLALVYLPGVIAAIVQLHNGTKYkkfphwlDKWMLTRKQFGLLSFFFAVLHAIYSLSYPMRRSyrykllnway 197
Cdd:pfam01794   1 LGILALALLPLLLLLALRNNPLEWLTGLSY-------DRLLLFHRWLGRLAFLLALLHVILYLIYWLRFS---------- 63

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 9558759    198 qqvqqnkedAWIEHDVWRMEIYVSLGIVGLAILALLAVTSIPSVSdSLTWREFHYIQSKLGIVSLLL 264
Cdd:pfam01794  64 ---------LEGILDLLLKRPYNILGIIALVLLVLLAITSLPPFR-RLSYELFLYLHILLAVAFLLL 120
PRK05419 PRK05419
protein-methionine-sulfoxide reductase heme-binding subunit MsrQ;
157-316 4.20e-04

protein-methionine-sulfoxide reductase heme-binding subunit MsrQ;


Pssm-ID: 235452  Cd Length: 205  Bit Score: 41.00  E-value: 4.20e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9558759   157 WMLTRKQFGLLSFFFAVLHAiysLSYpmrrSYRYKLLNWAYqqvqqnkedawiehdVWRmEI----YVSLGIVGLAILAL 232
Cdd:PRK05419  73 LIRTRRLLGLWAFFYATLHL---LSY----LLLDLGLDWSL---------------LGK-EIvkrpYITVGMAAFLILLP 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9558759   233 LAVTSIPSVSDSL--TWREFHyiqsKLGIVSLLLGTIHaliFAWNKWIDIKQfvwytPptfMIAVFLPIVVLIFKSILFL 310
Cdd:PRK05419 130 LALTSTRASQRRLgkRWQKLH----RLVYLIAILAPLH---YLWSVKSDSPE-----P---LIYAAIVAVLLALRLKKLR 194


                 ....*.
gi 9558759   311 PCLRKK 316
Cdd:PRK05419 195 RRWRRL 200
COG4097 COG4097
Predicted ferric reductase [Inorganic ion transport and metabolism];
151-310 1.21e-03

Predicted ferric reductase [Inorganic ion transport and metabolism];


Pssm-ID: 443273 [Multi-domain]  Cd Length: 442  Bit Score: 40.26  E-value: 1.21e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9558759  151 PHWLDKWM-----LTR--KQFGLLSFFFAVLH-AIYSLSYPMRRsyryklLNWAYQQVqqnkEDAWIEHDVWRMEiyvsL 222
Cdd:COG4097  64 PPWLERPFggldrLYRlhKWLGILALVLALAHpLLLLGPKWLVG------WGGLPARL----AALLTLLRGLAEL----L 129

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 9558759  223 GIVGLAILALLAVTSIpsVSDSLTWREFHYIQSKLGIVSLLLGTIHALIFAWNKWIDIKQFVWYtppTFMIAVFLPIVVL 302
Cdd:COG4097 130 GEWAFYLLLALVVLSL--LRRRLPYELWRLTHRLLAVAYLLLAFHHLLLGGPFYWSPPAGVLWA---ALAAAGLAAAVYS 204


                ....*...
gi 9558759  303 IFKSILFL 310
Cdd:COG4097 205 RLGRPLRS 212
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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