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Conserved domains on  [gi|6912328|ref|NP_036269|]
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N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 isoform 1 [Homo sapiens]

Protein Classification

dimethylarginine dimethylaminohydrolase family protein( domain architecture ID 10004634)

dimethylarginine dimethylaminohydrolase (DdaH) family protein similar to Pseudomonas aeruginosa N(G),N(G)-dimethylarginine dimethylaminohydrolase that hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DdaH COG1834
N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism];
28-276 2.93e-39

N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism];


:

Pssm-ID: 441439 [Multi-domain]  Cd Length: 264  Bit Score: 138.00  E-value: 2.93e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6912328   28 HALRSAKGEEVDVARAERQHQLYVGVLgSKLGLQVVELPADESLPDCVFVEDVAVVCEETALITRPGAPSRRKEVDMMKE 107
Cdd:COG1834  20 DPLREWAGPPPDAERAVAQWDALVDAL-EALGVEVHRLPPVPGLPDMVFTRDAGLVIGDGAILARMRHPERRGEEAAYRE 98

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6912328  108 ALEKLQLNIVEMKDEnATLDGGDVLFTGREFFVGLSKRTNQRGAEILADTFkDYAVSTVPVADG--LHLKSFCSMAGPNL 185
Cdd:COG1834  99 WLEELGIPVVRLPEP-GVFEGGDVLLDGDTLLVGYGFRTNRAGIEWLARLL-GYEVVPLELVDPrfLHLDTAFCPLAPGL 176

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6912328  186 IAI---GSSESAQKALKimqqmsDHRYDKLTVPDD----IAANCiyLNIPNKgHVLLHrtpeeyPESAKVYEKLKDHML- 257
Cdd:COG1834 177 ALVypeAFDPESLALLK------EPGWDLIEVPEEeaawLGCNV--LSLGGR-RVVSP------AGNPRLNAALRAAGFe 241

                       250       260
                ....*....|....*....|
gi 6912328  258 -IPVSMSELEKVDGLLTCCS 276
Cdd:COG1834 242 vIEVDLSEFLKGGGGFHCLT 261
 
Name Accession Description Interval E-value
DdaH COG1834
N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism];
28-276 2.93e-39

N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism];


Pssm-ID: 441439 [Multi-domain]  Cd Length: 264  Bit Score: 138.00  E-value: 2.93e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6912328   28 HALRSAKGEEVDVARAERQHQLYVGVLgSKLGLQVVELPADESLPDCVFVEDVAVVCEETALITRPGAPSRRKEVDMMKE 107
Cdd:COG1834  20 DPLREWAGPPPDAERAVAQWDALVDAL-EALGVEVHRLPPVPGLPDMVFTRDAGLVIGDGAILARMRHPERRGEEAAYRE 98

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6912328  108 ALEKLQLNIVEMKDEnATLDGGDVLFTGREFFVGLSKRTNQRGAEILADTFkDYAVSTVPVADG--LHLKSFCSMAGPNL 185
Cdd:COG1834  99 WLEELGIPVVRLPEP-GVFEGGDVLLDGDTLLVGYGFRTNRAGIEWLARLL-GYEVVPLELVDPrfLHLDTAFCPLAPGL 176

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6912328  186 IAI---GSSESAQKALKimqqmsDHRYDKLTVPDD----IAANCiyLNIPNKgHVLLHrtpeeyPESAKVYEKLKDHML- 257
Cdd:COG1834 177 ALVypeAFDPESLALLK------EPGWDLIEVPEEeaawLGCNV--LSLGGR-RVVSP------AGNPRLNAALRAAGFe 241

                       250       260
                ....*....|....*....|
gi 6912328  258 -IPVSMSELEKVDGLLTCCS 276
Cdd:COG1834 242 vIEVDLSEFLKGGGGFHCLT 261
PRK01388 PRK01388
arginine deiminase; Provisional
 115-180 7.49e-04

arginine deiminase; Provisional


Pssm-ID: 234949  Cd Length: 406  Bit Score: 40.53  E-value: 7.49e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 6912328   115 NIVEMKDENATLDGGDVLFTGRE-FFVGLSKRTNQRGAEILADT-FKDYAVSTVPVAD------GLHLKSFCSM 180
Cdd:PRK01388 203 PVWDDRHGNATLEGGDVLVLGKGvVAIGMSERTSPQAIEQLARSlFKKGAAKRVLAVEipksraFMHLDTVFTM 276
 
Name Accession Description Interval E-value
DdaH COG1834
N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism];
28-276 2.93e-39

N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism];


Pssm-ID: 441439 [Multi-domain]  Cd Length: 264  Bit Score: 138.00  E-value: 2.93e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6912328   28 HALRSAKGEEVDVARAERQHQLYVGVLgSKLGLQVVELPADESLPDCVFVEDVAVVCEETALITRPGAPSRRKEVDMMKE 107
Cdd:COG1834  20 DPLREWAGPPPDAERAVAQWDALVDAL-EALGVEVHRLPPVPGLPDMVFTRDAGLVIGDGAILARMRHPERRGEEAAYRE 98

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6912328  108 ALEKLQLNIVEMKDEnATLDGGDVLFTGREFFVGLSKRTNQRGAEILADTFkDYAVSTVPVADG--LHLKSFCSMAGPNL 185
Cdd:COG1834  99 WLEELGIPVVRLPEP-GVFEGGDVLLDGDTLLVGYGFRTNRAGIEWLARLL-GYEVVPLELVDPrfLHLDTAFCPLAPGL 176

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6912328  186 IAI---GSSESAQKALKimqqmsDHRYDKLTVPDD----IAANCiyLNIPNKgHVLLHrtpeeyPESAKVYEKLKDHML- 257
Cdd:COG1834 177 ALVypeAFDPESLALLK------EPGWDLIEVPEEeaawLGCNV--LSLGGR-RVVSP------AGNPRLNAALRAAGFe 241

                       250       260
                ....*....|....*....|
gi 6912328  258 -IPVSMSELEKVDGLLTCCS 276
Cdd:COG1834 242 vIEVDLSEFLKGGGGFHCLT 261
PRK01388 PRK01388
arginine deiminase; Provisional
 115-180 7.49e-04

arginine deiminase; Provisional


Pssm-ID: 234949  Cd Length: 406  Bit Score: 40.53  E-value: 7.49e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 6912328   115 NIVEMKDENATLDGGDVLFTGRE-FFVGLSKRTNQRGAEILADT-FKDYAVSTVPVAD------GLHLKSFCSM 180
Cdd:PRK01388 203 PVWDDRHGNATLEGGDVLVLGKGvVAIGMSERTSPQAIEQLARSlFKKGAAKRVLAVEipksraFMHLDTVFTM 276
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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