|
Name |
Accession |
Description |
Interval |
E-value |
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
568-1565 |
0e+00 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 1182.64 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 568 GKHSMRTRRSRGSMSTLRSGRKKQPASPDGRTSPINEDIRSSGRNSPSAASTSSNDSKAETVKKSAKKVKEEASSPLKSN 647
Cdd:pfam03154 1 GKHSMRTRRSRGSMSTLRSGRKKQTASPDGRASPTNEDLRSSGRNSPSAASTSSNDSKAESMKKSSKKIKEEAPSPLKSA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 648 KRQREKVASDTEEADRTSSKKTKTQEISRPNSPSEGEGESSDSRSVNDEGSSDPKDIDQDNRSTSPSIPSPQDNESDSDS 727
Cdd:pfam03154 81 KRQREKGASDTEEPERATAKKSKTQEISRPNSPSEGEGESSDGRSVNDEGSSDPKDIDQDNRSTSPSIPSPQDNESDSDS 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 728 SAQQQMLQAQPPALQAPTGVTPAPSSAPPGTPQLPTPGPTPSATAVPPQGSPTASQAPNQPQAPTAPvpHTHIQQAPALH 807
Cdd:pfam03154 161 SAQQQILQTQPPVLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAP--HTLIQQTPTLH 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 808 PQRPPSPHPPPHPSPHPPLQPltgsagQPSAPSHAQPPLHGQGPPGPHSLQAGP-LLQHPGPPQPFGLPPQASQGQAPLG 886
Cdd:pfam03154 239 PQRLPSPHPPLQPMTQPPPPS------QVSPQPLPQPSLHGQMPPMPHSLQTGPsHMQHPVPPQPFPLTPQSSQSQVPPG 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 887 TSPAAAYP-HTSLQLPASQSALQSQQPPREQPLPPAPLAMPHIKPPPTTPIPQLPAPQAHKHPPHLSGPSPFSMNANLPP 965
Cdd:pfam03154 313 PSPAAPGQsQQRIHTPPSQSQLQSQQPPREQPLPPAPLSMPHIKPPPTTPIPQLPNPQSHKHPPHLSGPSPFQMNSNLPP 392
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 966 PPALKPLSSLSTHHPPSAHPPPLQLMPQSQPLPSSPAQPPGLTQSQNLPPPPASHPPT-GLHQVAPQPPFAQHPFVPGGP 1044
Cdd:pfam03154 393 PPALKPLSSLSTHHPPSAHPPPLQLMPQSQQLPPPPAQPPVLTQSQSLPPPAASHPPTsGLHQVPSQSPFPQHPFVPGGP 472
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 1045 PPITPPTCPSTSTPPAGPGTsaQPPCSGAAASGGSIAGGSSCPLPTVQIKEEALDDAEEPESPPPPPRSPSPEPTVVDTP 1124
Cdd:pfam03154 473 PPITPPSGPPTSTSSAMPGI--QPPSSASVSSSGPVPAAVSCPLPPVQIKEEALDEAEEPESPPPPPRSPSPEPTVVNTP 550
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 1125 SHASQSARFYKHLDRGYNSCARTDLYFMPLAGSKLAKKREEAIEKAKREAEQKAREEREREKEKEKEREREREREREAER 1204
Cdd:pfam03154 551 SHASQSARFYKHLDRGYNSCARTDLYFMPLAGSKLAKKREEALEKAKREAEQKAREEKEREKEKEKEREREREREREAER 630
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 1205 AAKASSSAHEGRLSDPQLSGPGHMRPSFEPPPTTIAAVPPYIGPDTPALRTLSEYARPHVMSPTNRNHPFYMPLNPTDPL 1284
Cdd:pfam03154 631 AAKASSSSHEGRMGDPQLAGPAHMRPSFEPPPTTIAAVPPYIGPDTPALRTLSEYARPHVMSPTNRNHPFFVPLNPTDPL 710
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 1285 LAYHMPGLYNVDPTIRERELREREIREREIRERELRERMKPGFEVKPPELDPLHPAANPMEHFARHSALTIPPTAGPHPF 1364
Cdd:pfam03154 711 LAYHMPGLYNVDPAIRERELREREIREREIRERELRERMKPGFEVKPPELDPLHPATNPMEHFARHGALTLPPMAGPHPF 790
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 1365 ASFHPGLNPLERERLALAGPQLRPEMSYPDRLAAERIHAERMASLTSDPLARLQMFNVTPHHHQHSHIHSHLHLHQQDPL 1444
Cdd:pfam03154 791 ASFHPGLNPLERERLALAGPQLRPEMSYPDRLAAERLHAERMASLTNDPLARLQMFNVTPHHHQHSHIHSHLHLHQQDPL 870
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 1445 HQGSAGPVHPLVDPLTAGPHLARFPYPPGTLPNPLLGQPPHEHEMLRHPVFGTPYPRDLPGAIPPPMSAAHQLQAMHAQS 1524
Cdd:pfam03154 871 HQGSGGPVHPLVDPLAAGPHLARFPYPPGAIPNPLLGQPPHEHEMLRHPVFGTPYPRDLPGGLPPPMSAAHQLQAMHAQS 950
|
970 980 990 1000
....*....|....*....|....*....|....*....|.
gi 112382216 1525 AELQRLAMEQQWLHGHPHMHGGHLPSQEDYYSRLKKEGDKQ 1565
Cdd:pfam03154 951 AELQRLAMEQQWLHGHPHMHGGHLPGQEDYYSRLKKESDKQ 991
|
|
| BAH_MTA |
cd04709 |
BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The ... |
102-307 |
4.76e-81 |
|
BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH domains are found in a variety of proteins playing roles in transcriptional silencing and the remodeling of chromatin. It is assumed that in most or all of these instances the BAH domain mediates protein-protein interactions.
Pssm-ID: 240060 Cd Length: 164 Bit Score: 263.48 E-value: 4.76e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 102 DVVYRPGDCVYIESRrPNTPYFICSIQDFKLvhnsqaccrsptpalcdppacslpvasqppqhlseagrgpvgSKRDHLL 181
Cdd:cd04709 1 ANMYRVGDYVYFESS-PNNPYLIRRIEELNK------------------------------------------TARGHVE 37
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 182 MNVKWYYRQSEVPDSVYQHLVQDRHNEND-SGRELVITDPVIKNRELFISDYVDTYHAAALRGKCNISHFSDIFAAREFK 260
Cdd:cd04709 38 AKVVCYYRRRDIPDSLYQLADQHRRELEEkSDDLTPKQRHQLRHRELFLSRQVETLPATHIRGKCSVTLLNDTESARSYL 117
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 112382216 261 ARVDSFFYILGYNPETRRLNSTQGEIRVGPSHQAKLPDLQPFPSPDG 307
Cdd:cd04709 118 AREDTFFYSLVYDPEQKTLLADQGEIRVGPSYQAKLPDLQPFPSPDG 164
|
|
| SANT_MTA3_like |
cd11661 |
Myb-Like Dna-Binding Domain of MTA3 and related proteins; Members in this SANT/myb family ... |
395-440 |
4.33e-23 |
|
Myb-Like Dna-Binding Domain of MTA3 and related proteins; Members in this SANT/myb family include domains found in mouse metastasis-associated protein 3 (MTA3) proteins and arginine-glutamic dipeptide (RERE) repeats proteins. SANT (SWI3, ADA2, N-CoR and TFIIIB) DNA-binding domains are a diverse set of proteins that share a common 3 alpha-helix bundle. MTA3 has been shown to interact with nucleosome remodeling and deacetylase (NuRD) proteins CHD4 and HDAC1, and the core cohesin complex protein RAD21 in the ovary, and regulate G2/M progression in proliferating granulosa cells. RERE belongs to the atrophin family and has been identified as a nuclear receptor corepressor; altered expression levels of RERE are associated with cancer in humans while mutations of Rere in mice cause failure in closing the anterior neural tube and fusion of the telencephalic and optic vesicles during embryogenesis.
Pssm-ID: 212559 [Multi-domain] Cd Length: 46 Bit Score: 93.45 E-value: 4.33e-23
10 20 30 40
....*....|....*....|....*....|....*....|....*.
gi 112382216 395 CWTEDEVKRFVKGLRQYGKNFFRIRKELLPNKETGELITFYYYWKK 440
Cdd:cd11661 1 EWSESEAKLFEEGLRKYGKDFHDIRQDFLPWKSVGELVEFYYMWKK 46
|
|
| ZnF_GATA |
smart00401 |
zinc finger binding to DNA consensus sequence [AT]GATA[AG]; |
503-552 |
3.08e-15 |
|
zinc finger binding to DNA consensus sequence [AT]GATA[AG];
Pssm-ID: 214648 [Multi-domain] Cd Length: 52 Bit Score: 71.30 E-value: 3.08e-15
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 112382216 503 KGYACRHCFTTTSKDWHHGGRENILLCTDCRIHFKKYGEL-PPIEKPVDPP 552
Cdd:smart00401 2 SGRSCSNCGTTETPLWRRGPSGNKTLCNACGLYYKKHGGLkRPLSLKKDGI 52
|
|
| ZnF_GATA |
cd00202 |
Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] ... |
506-560 |
3.28e-15 |
|
Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
Pssm-ID: 238123 [Multi-domain] Cd Length: 54 Bit Score: 71.25 E-value: 3.28e-15
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 112382216 506 ACRHCFTTTSKDWHHGGRENILLCTDCRIHFKKYGELPPIEKPvDPPPFMFKPVK 560
Cdd:cd00202 1 ACSNCGTTTTPLWRRGPSGGSTLCNACGLYWKKHGVMRPLSKR-KKDQIKRRNRK 54
|
|
| ELM2 |
pfam01448 |
ELM2 domain; The ELM2 (Egl-27 and MTA1 homology 2) domain is a small domain of unknown ... |
286-336 |
2.45e-12 |
|
ELM2 domain; The ELM2 (Egl-27 and MTA1 homology 2) domain is a small domain of unknown function. It is found in the MTA1 protein that is part of the NuRD complex. The domain is usually found to the N terminus of a myb-like DNA binding domain pfam00249. ELM2 is also found associated with an ARID DNA binding domain pfam01388 in Swiss:O82364. This suggests that ELM2 may also be involved in DNA binding, or perhaps is a protein-protein interaction domain.
Pssm-ID: 460214 Cd Length: 53 Bit Score: 63.02 E-value: 2.45e-12
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 112382216 286 IRVGPSHQAKLPDLQPFPSPDGDTVTQHEELVWMP--GVNDCDLLMYLRAARS 336
Cdd:pfam01448 1 IRVGPRYQAEIPELLPPSEEEDRYEEEDELLVWDPnhNLPDRKLDEYLVVARS 53
|
|
| GATA |
pfam00320 |
GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This ... |
507-542 |
1.25e-11 |
|
GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This domain binds to DNA. Two GATA zinc fingers are found in the GATA transcription factors. However there are several proteins which only contain a single copy of the domain.
Pssm-ID: 425605 [Multi-domain] Cd Length: 36 Bit Score: 60.41 E-value: 1.25e-11
10 20 30
....*....|....*....|....*....|....*.
gi 112382216 507 CRHCFTTTSKDWHHGGRENILLCTDCRIHFKKYGEL 542
Cdd:pfam00320 1 CSNCGTTKTPLWRRGPNGNRTLCNACGLYYKKKGLK 36
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
540-956 |
1.49e-11 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 69.97 E-value: 1.49e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 540 GELPPIEKPVDPPPFMFKPVKEeddglsgkhSMRTRRSRGSMSTLRSGRKKQPASPDGRTSPINE--DIRSSGRNSPSAA 617
Cdd:PHA03247 2549 GDPPPPLPPAAPPAAPDRSVPP---------PRPAPRPSEPAVTSRARRPDAPPQSARPRAPVDDrgDPRGPAPPSPLPP 2619
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 618 STSSNDSKAETVKKSAKKVKEEASSPLKSNKRQREKVASDTEEADRTSSKKTKTqeiSRPNSPSEGEGESSDSRSVNDEG 697
Cdd:PHA03247 2620 DTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRA---AQASSPPQRPRRRAARPTVGSLT 2696
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 698 SS-----DPKDIDQDNRSTSPSIPSPQDNESDSDSSAQQQMLQAQPPALQAP-TGVTPAPSSAPPGTPQLPTPGPTPSAT 771
Cdd:PHA03247 2697 SLadpppPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPaTPGGPARPARPPTTAGPPAPAPPAAPA 2776
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 772 AVPPQGSPTASQAPNQPQAPTAPVPhthiqQAPALHPQRPPSPHPPPHPSPHPPLQPLTGSAGQPSAPSHAQPPLHGQGP 851
Cdd:PHA03247 2777 AGPPRRLTRPAVASLSESRESLPSP-----WDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLP 2851
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 852 PGPHSLQAGPLLQHPGPPQPFGLPPQASQGQAPLGTSPAAAYPHTSLQLPASQSALQSQQPPREQPLPPAPLAMPHIKPP 931
Cdd:PHA03247 2852 LGGSVAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQP 2931
|
410 420
....*....|....*....|....*.
gi 112382216 932 PTTPIPQLPAPQA-HKHPPHLSGPSP 956
Cdd:PHA03247 2932 PPPPPPRPQPPLApTTDPAGAGEPSG 2957
|
|
| BAH |
pfam01426 |
BAH domain; This domain has been called BAH (Bromo adjacent homology) domain and has also been ... |
103-281 |
6.30e-10 |
|
BAH domain; This domain has been called BAH (Bromo adjacent homology) domain and has also been called ELM1 and BAM (Bromo adjacent motif) domain. The function of this domain is unknown but may be involved in protein-protein interaction.
Pssm-ID: 460207 Cd Length: 120 Bit Score: 58.47 E-value: 6.30e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 103 VVYRPGDCVYIESRRPNTPYFICSIQDFKlvhnsqaccrsptpalCDPPACSLPVasqppqhlseagrgpvgskrdhllm 182
Cdd:pfam01426 1 ETYSVGDFVLVEPDDADEPYYVARIEELF----------------EDTKNGKKMV------------------------- 39
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 183 NVKWYYRQSEVPdsvyqHLVQDRHNEndsgrelvitdpviknRELFISDYVDTYHAAALRGKCNISHFSDIFAAREFK-A 261
Cdd:pfam01426 40 RVQWFYRPEETV-----HRAGKAFNK----------------DELFLSDEEDDVPLSAIIGKCSVLHKSDLESLDPYKiK 98
|
170 180
....*....|....*....|
gi 112382216 262 RVDSFFYILGYNPETRRLNS 281
Cdd:pfam01426 99 EPDDFFCELLYDPKTKSFKK 118
|
|
| BAH |
smart00439 |
Bromo adjacent homology domain; |
105-281 |
1.55e-09 |
|
Bromo adjacent homology domain;
Pssm-ID: 214664 [Multi-domain] Cd Length: 121 Bit Score: 57.30 E-value: 1.55e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 105 YRPGDCVYIESRRPNTPYFICSIQDfklvhnsqaccrsptpaLCDPPACSLPVASQppqhlseagrgpvgskrdhllmnV 184
Cdd:smart00439 2 ISVGDFVLVEPDDADEPYYIGRIEE-----------------IFETKKNSESKMVR-----------------------V 41
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 185 KWYYRQSEVPdsvyqHLVQDRHNENdsgrelvitdpviknrELFISDYVDTYHAAALRGKCNISHFSDIF--AAREFKAR 262
Cdd:smart00439 42 RWFYRPEETV-----LEKAALFDKN----------------EVFLSDEYDTVPLSDIIGKCNVLYKSDYPglRPEGSIGE 100
|
170
....*....|....*....
gi 112382216 263 VDSFFYILGYNPETRRLNS 281
Cdd:smart00439 101 PDVFFCESAYDPEKGSFKK 119
|
|
| MSCRAMM_ClfA |
NF033609 |
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ... |
545-729 |
9.44e-09 |
|
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.
Pssm-ID: 468110 [Multi-domain] Cd Length: 934 Bit Score: 60.31 E-value: 9.44e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 545 IEKPVDPP----PFMFKPVKEEDDGLSGKHSMRTRRSR------GSMSTLRSGRKKQPASPDGRTSPINEDIRSSGRNSP 614
Cdd:NF033609 539 IDKPVVPEqpdePGEIEPIPEDSDSDPGSDSGSDSSNSdsgsdsGSDSTSDSGSDSASDSDSASDSDSASDSDSASDSDS 618
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 615 SAASTSSNDSKAETVKKSAKKVKEEASSPLKSNKRQREKVASDTEeADRTSSKKTKTQEISRPNSPSEGEGES-SDSRSV 693
Cdd:NF033609 619 ASDSDSASDSDSASDSDSASDSDSDSDSDSDSDSDSDSDSDSDSD-SDSDSDSDSDSDSDSDSDSDSDSDSDSdSDSDSD 697
|
170 180 190
....*....|....*....|....*....|....*.
gi 112382216 694 NDEGSSDPKDIDQDNRSTSPSiPSPQDNESDSDSSA 729
Cdd:NF033609 698 SDSDSDSDSDSDSDSDSDSDS-DSDSDSDSDSDSDS 732
|
|
| PspC_subgroup_1 |
NF033838 |
pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, ... |
557-804 |
4.95e-06 |
|
pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A. The other form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site.
Pssm-ID: 468201 [Multi-domain] Cd Length: 684 Bit Score: 51.17 E-value: 4.95e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 557 KPVKEEDDGLSGKHSMRTRRSRGSMStlrsgrkkQPASPDGRTSPINEDIRSSGRNSPSAASTSSNDSKAEtvkksAKKV 636
Cdd:NF033838 246 KEAVEKNVATSEQDKPKRRAKRGVLG--------EPATPDKKENDAKSSDSSVGEETLPSPSLKPEKKVAE-----AEKK 312
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 637 KEEAssplksnkrqrEKVASDTEEADR----TSSKKTKTQEISRPNSP-SEGE-----GESSDSRsvNDEGSSDPKDIDQ 706
Cdd:NF033838 313 VEEA-----------KKKAKDQKEEDRrnypTNTYKTLELEIAESDVKvKEAElelvkEEAKEPR--NEEKIKQAKAKVE 379
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 707 DNRSTSPSIPSPQDNESDSDSSAQQQMlqaqppALQAPTGVTPAPSSAPPGTPQLPTPGPTPSATAVPPQGSPTASQAPN 786
Cdd:NF033838 380 SKKAEATRLEKIKTDRKKAEEEAKRKA------AEEDKVKEKPAEQPQPAPAPQPEKPAPKPEKPAEQPKAEKPADQQAE 453
|
250
....*....|....*....
gi 112382216 787 QPQAPTAP-VPHTHIQQAP 804
Cdd:NF033838 454 EDYARRSEeEYNRLTQQQP 472
|
|
| SANT |
smart00717 |
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains; |
396-441 |
3.89e-05 |
|
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
Pssm-ID: 197842 [Multi-domain] Cd Length: 49 Bit Score: 42.60 E-value: 3.89e-05
10 20 30 40
....*....|....*....|....*....|....*....|....*..
gi 112382216 396 WTEDEVKRFVKGLRQYG-KNFFRIRKElLPNKETGELITFYYYWKKT 441
Cdd:smart00717 4 WTEEEDELLIELVKKYGkNNWEKIAKE-LPGRTAEQCRERWRNLLKP 49
|
|
| MSCRAMM_ClfA |
NF033609 |
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ... |
580-729 |
7.10e-05 |
|
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.
Pssm-ID: 468110 [Multi-domain] Cd Length: 934 Bit Score: 47.60 E-value: 7.10e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 580 SMSTLRSGRKKQPASPDGRTSPINEDIRSSGRNSPSAASTSSNDSKAETVKKSAKKVKEEASSPLKSNKRQREKVASDTE 659
Cdd:NF033609 630 SASDSDSASDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 709
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 112382216 660 -EADRTSSKKTKTQEISRPNSPSEGEGES-SDSRSVNDEGSSDPKDIDQDNRSTSPSiPSPQDNESDSDSSA 729
Cdd:NF033609 710 sDSDSDSDSDSDSDSDSDSDSDSDSDSDSdSDSDSDSDSDSDSDSDSDSDSDSDSDS-DSDSDSDSDSDSDS 780
|
|
| MSCRAMM_ClfA |
NF033609 |
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ... |
600-798 |
7.93e-05 |
|
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.
Pssm-ID: 468110 [Multi-domain] Cd Length: 934 Bit Score: 47.60 E-value: 7.93e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 600 SPINEDIRSSGRNSPSAASTSSNDSKAETVKKSAKKVKEEASSPLKSNKRQREKVASDTE-EADRTSSKKTKTQEISRPN 678
Cdd:NF033609 704 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDsDSDSDSDSDSDSDSDSDSD 783
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 679 SPSEGEGES-SDSRSVNDEGSSDPKDIDQDNRSTSPSiPSPQDNESDSDS-----SAQQQMLQAQPPALQAPTGVTPAPS 752
Cdd:NF033609 784 SDSDSDSDSdSDSDSDSDSDSDSDSDSDSDSDSDSDS-DSDSDSDSDSDSdsdsdSDSDSDSDSDSDSDSDSDSESDSNS 862
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 112382216 753 SAPPGTpqlptpgptpSATAVPPQGSPTASQAPNQPQAPTA--PVPHT 798
Cdd:NF033609 863 DSESGS----------NNNVVPPNSPKNGTNASNKNEAKDSkePLPDT 900
|
|
| MSCRAMM_ClfA |
NF033609 |
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ... |
580-729 |
1.01e-04 |
|
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.
Pssm-ID: 468110 [Multi-domain] Cd Length: 934 Bit Score: 47.21 E-value: 1.01e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 580 SMSTLRSGRKKQPASPDGRTSPINEDIRSSGRNSPSAASTSSNDSKAETVKKSAKKVKEEASSPLKSNKRQREKVASDTE 659
Cdd:NF033609 650 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 729
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 112382216 660 -EADRTSSKKTKTQEISRPNSPSEGEGES---SDSRSVNDEGSSDPKDIDQDNRSTSPSiPSPQDNESDSDSSA 729
Cdd:NF033609 730 sDSDSDSDSDSDSDSDSDSDSDSDSDSDSdsdSDSDSDSDSDSDSDSDSDSDSDSDSDS-DSDSDSDSDSDSDS 802
|
|
| Myb_DNA-binding |
pfam00249 |
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ... |
396-439 |
1.04e-04 |
|
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.
Pssm-ID: 459731 [Multi-domain] Cd Length: 46 Bit Score: 40.95 E-value: 1.04e-04
10 20 30 40
....*....|....*....|....*....|....*....|....
gi 112382216 396 WTEDEVKRFVKGLRQYGKNFFRIrKELLPNKETGELITFYYYWK 439
Cdd:pfam00249 4 WTPEEDELLLEAVEKLGNRWKKI-AKLLPGRTDNQCKNRWQNYL 46
|
|
| PABP-1234 |
TIGR01628 |
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ... |
756-916 |
2.16e-03 |
|
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.
Pssm-ID: 130689 [Multi-domain] Cd Length: 562 Bit Score: 42.49 E-value: 2.16e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 756 PGTPQLPTPGPTPSATAVPPQGSPtasqapnQPQAPTAPVPHTHIQQAPalhpqrppsphppphpsphpplqplTGSAGQ 835
Cdd:TIGR01628 380 PRMRQLPMGSPMGGAMGQPPYYGQ-------GPQQQFNGQPLGWPRMSM-------------------------MPTPMG 427
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 836 PSAPSHAQ--PPLHGQGPPGPHSLQAgpllQHPGPPQPFGLPPQASQGQAPLGTSPAAAYPHTSLQLPASQSALQSqQPP 913
Cdd:TIGR01628 428 PGGPLRPNglAPMNAVRAPSRNAQNA----AQKPPMQPVMYPPNYQSLPLSQDLPQPQSTASQGGQNKKLAQVLAS-ATP 502
|
...
gi 112382216 914 REQ 916
Cdd:TIGR01628 503 QMQ 505
|
|
| COG5373 |
COG5373 |
Uncharacterized membrane protein [Function unknown]; |
728-805 |
2.17e-03 |
|
Uncharacterized membrane protein [Function unknown];
Pssm-ID: 444140 [Multi-domain] Cd Length: 854 Bit Score: 42.68 E-value: 2.17e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 112382216 728 SAQQQMLQAQPPAlqAPTGVTPAPSSAPPGTPQLPTPGPTPSATAVPPQGSPTASQAPNQPQAPTAPVPhthiQQAPA 805
Cdd:COG5373 31 EELEAELAEAAEA--ASAPAEPEPEAAAAATAAAPEAAPAPVPEAPAAPPAAAEAPAPAAAAPPAEAEP----AAAPA 102
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
568-1565 |
0e+00 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 1182.64 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 568 GKHSMRTRRSRGSMSTLRSGRKKQPASPDGRTSPINEDIRSSGRNSPSAASTSSNDSKAETVKKSAKKVKEEASSPLKSN 647
Cdd:pfam03154 1 GKHSMRTRRSRGSMSTLRSGRKKQTASPDGRASPTNEDLRSSGRNSPSAASTSSNDSKAESMKKSSKKIKEEAPSPLKSA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 648 KRQREKVASDTEEADRTSSKKTKTQEISRPNSPSEGEGESSDSRSVNDEGSSDPKDIDQDNRSTSPSIPSPQDNESDSDS 727
Cdd:pfam03154 81 KRQREKGASDTEEPERATAKKSKTQEISRPNSPSEGEGESSDGRSVNDEGSSDPKDIDQDNRSTSPSIPSPQDNESDSDS 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 728 SAQQQMLQAQPPALQAPTGVTPAPSSAPPGTPQLPTPGPTPSATAVPPQGSPTASQAPNQPQAPTAPvpHTHIQQAPALH 807
Cdd:pfam03154 161 SAQQQILQTQPPVLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAP--HTLIQQTPTLH 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 808 PQRPPSPHPPPHPSPHPPLQPltgsagQPSAPSHAQPPLHGQGPPGPHSLQAGP-LLQHPGPPQPFGLPPQASQGQAPLG 886
Cdd:pfam03154 239 PQRLPSPHPPLQPMTQPPPPS------QVSPQPLPQPSLHGQMPPMPHSLQTGPsHMQHPVPPQPFPLTPQSSQSQVPPG 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 887 TSPAAAYP-HTSLQLPASQSALQSQQPPREQPLPPAPLAMPHIKPPPTTPIPQLPAPQAHKHPPHLSGPSPFSMNANLPP 965
Cdd:pfam03154 313 PSPAAPGQsQQRIHTPPSQSQLQSQQPPREQPLPPAPLSMPHIKPPPTTPIPQLPNPQSHKHPPHLSGPSPFQMNSNLPP 392
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 966 PPALKPLSSLSTHHPPSAHPPPLQLMPQSQPLPSSPAQPPGLTQSQNLPPPPASHPPT-GLHQVAPQPPFAQHPFVPGGP 1044
Cdd:pfam03154 393 PPALKPLSSLSTHHPPSAHPPPLQLMPQSQQLPPPPAQPPVLTQSQSLPPPAASHPPTsGLHQVPSQSPFPQHPFVPGGP 472
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 1045 PPITPPTCPSTSTPPAGPGTsaQPPCSGAAASGGSIAGGSSCPLPTVQIKEEALDDAEEPESPPPPPRSPSPEPTVVDTP 1124
Cdd:pfam03154 473 PPITPPSGPPTSTSSAMPGI--QPPSSASVSSSGPVPAAVSCPLPPVQIKEEALDEAEEPESPPPPPRSPSPEPTVVNTP 550
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 1125 SHASQSARFYKHLDRGYNSCARTDLYFMPLAGSKLAKKREEAIEKAKREAEQKAREEREREKEKEKEREREREREREAER 1204
Cdd:pfam03154 551 SHASQSARFYKHLDRGYNSCARTDLYFMPLAGSKLAKKREEALEKAKREAEQKAREEKEREKEKEKEREREREREREAER 630
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 1205 AAKASSSAHEGRLSDPQLSGPGHMRPSFEPPPTTIAAVPPYIGPDTPALRTLSEYARPHVMSPTNRNHPFYMPLNPTDPL 1284
Cdd:pfam03154 631 AAKASSSSHEGRMGDPQLAGPAHMRPSFEPPPTTIAAVPPYIGPDTPALRTLSEYARPHVMSPTNRNHPFFVPLNPTDPL 710
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 1285 LAYHMPGLYNVDPTIRERELREREIREREIRERELRERMKPGFEVKPPELDPLHPAANPMEHFARHSALTIPPTAGPHPF 1364
Cdd:pfam03154 711 LAYHMPGLYNVDPAIRERELREREIREREIRERELRERMKPGFEVKPPELDPLHPATNPMEHFARHGALTLPPMAGPHPF 790
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 1365 ASFHPGLNPLERERLALAGPQLRPEMSYPDRLAAERIHAERMASLTSDPLARLQMFNVTPHHHQHSHIHSHLHLHQQDPL 1444
Cdd:pfam03154 791 ASFHPGLNPLERERLALAGPQLRPEMSYPDRLAAERLHAERMASLTNDPLARLQMFNVTPHHHQHSHIHSHLHLHQQDPL 870
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 1445 HQGSAGPVHPLVDPLTAGPHLARFPYPPGTLPNPLLGQPPHEHEMLRHPVFGTPYPRDLPGAIPPPMSAAHQLQAMHAQS 1524
Cdd:pfam03154 871 HQGSGGPVHPLVDPLAAGPHLARFPYPPGAIPNPLLGQPPHEHEMLRHPVFGTPYPRDLPGGLPPPMSAAHQLQAMHAQS 950
|
970 980 990 1000
....*....|....*....|....*....|....*....|.
gi 112382216 1525 AELQRLAMEQQWLHGHPHMHGGHLPSQEDYYSRLKKEGDKQ 1565
Cdd:pfam03154 951 AELQRLAMEQQWLHGHPHMHGGHLPGQEDYYSRLKKESDKQ 991
|
|
| BAH_MTA |
cd04709 |
BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The ... |
102-307 |
4.76e-81 |
|
BAH, or Bromo Adjacent Homology domain, as present in MTA1 and similar proteins. The Metastasis-associated protein MTA1 is part of the NURD (nucleosome remodeling and deacetylating) complex and plays a role in cellular transformation and metastasis. BAH domains are found in a variety of proteins playing roles in transcriptional silencing and the remodeling of chromatin. It is assumed that in most or all of these instances the BAH domain mediates protein-protein interactions.
Pssm-ID: 240060 Cd Length: 164 Bit Score: 263.48 E-value: 4.76e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 102 DVVYRPGDCVYIESRrPNTPYFICSIQDFKLvhnsqaccrsptpalcdppacslpvasqppqhlseagrgpvgSKRDHLL 181
Cdd:cd04709 1 ANMYRVGDYVYFESS-PNNPYLIRRIEELNK------------------------------------------TARGHVE 37
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 182 MNVKWYYRQSEVPDSVYQHLVQDRHNEND-SGRELVITDPVIKNRELFISDYVDTYHAAALRGKCNISHFSDIFAAREFK 260
Cdd:cd04709 38 AKVVCYYRRRDIPDSLYQLADQHRRELEEkSDDLTPKQRHQLRHRELFLSRQVETLPATHIRGKCSVTLLNDTESARSYL 117
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 112382216 261 ARVDSFFYILGYNPETRRLNSTQGEIRVGPSHQAKLPDLQPFPSPDG 307
Cdd:cd04709 118 AREDTFFYSLVYDPEQKTLLADQGEIRVGPSYQAKLPDLQPFPSPDG 164
|
|
| SANT_MTA3_like |
cd11661 |
Myb-Like Dna-Binding Domain of MTA3 and related proteins; Members in this SANT/myb family ... |
395-440 |
4.33e-23 |
|
Myb-Like Dna-Binding Domain of MTA3 and related proteins; Members in this SANT/myb family include domains found in mouse metastasis-associated protein 3 (MTA3) proteins and arginine-glutamic dipeptide (RERE) repeats proteins. SANT (SWI3, ADA2, N-CoR and TFIIIB) DNA-binding domains are a diverse set of proteins that share a common 3 alpha-helix bundle. MTA3 has been shown to interact with nucleosome remodeling and deacetylase (NuRD) proteins CHD4 and HDAC1, and the core cohesin complex protein RAD21 in the ovary, and regulate G2/M progression in proliferating granulosa cells. RERE belongs to the atrophin family and has been identified as a nuclear receptor corepressor; altered expression levels of RERE are associated with cancer in humans while mutations of Rere in mice cause failure in closing the anterior neural tube and fusion of the telencephalic and optic vesicles during embryogenesis.
Pssm-ID: 212559 [Multi-domain] Cd Length: 46 Bit Score: 93.45 E-value: 4.33e-23
10 20 30 40
....*....|....*....|....*....|....*....|....*.
gi 112382216 395 CWTEDEVKRFVKGLRQYGKNFFRIRKELLPNKETGELITFYYYWKK 440
Cdd:cd11661 1 EWSESEAKLFEEGLRKYGKDFHDIRQDFLPWKSVGELVEFYYMWKK 46
|
|
| ZnF_GATA |
smart00401 |
zinc finger binding to DNA consensus sequence [AT]GATA[AG]; |
503-552 |
3.08e-15 |
|
zinc finger binding to DNA consensus sequence [AT]GATA[AG];
Pssm-ID: 214648 [Multi-domain] Cd Length: 52 Bit Score: 71.30 E-value: 3.08e-15
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 112382216 503 KGYACRHCFTTTSKDWHHGGRENILLCTDCRIHFKKYGEL-PPIEKPVDPP 552
Cdd:smart00401 2 SGRSCSNCGTTETPLWRRGPSGNKTLCNACGLYYKKHGGLkRPLSLKKDGI 52
|
|
| ZnF_GATA |
cd00202 |
Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] ... |
506-560 |
3.28e-15 |
|
Zinc finger DNA binding domain; binds specifically to DNA consensus sequence [AT]GATA[AG] promoter elements; a subset of family members may also bind protein; zinc-finger consensus topology is C-X(2)-C-X(17)-C-X(2)-C
Pssm-ID: 238123 [Multi-domain] Cd Length: 54 Bit Score: 71.25 E-value: 3.28e-15
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*
gi 112382216 506 ACRHCFTTTSKDWHHGGRENILLCTDCRIHFKKYGELPPIEKPvDPPPFMFKPVK 560
Cdd:cd00202 1 ACSNCGTTTTPLWRRGPSGGSTLCNACGLYWKKHGVMRPLSKR-KKDQIKRRNRK 54
|
|
| ELM2 |
pfam01448 |
ELM2 domain; The ELM2 (Egl-27 and MTA1 homology 2) domain is a small domain of unknown ... |
286-336 |
2.45e-12 |
|
ELM2 domain; The ELM2 (Egl-27 and MTA1 homology 2) domain is a small domain of unknown function. It is found in the MTA1 protein that is part of the NuRD complex. The domain is usually found to the N terminus of a myb-like DNA binding domain pfam00249. ELM2 is also found associated with an ARID DNA binding domain pfam01388 in Swiss:O82364. This suggests that ELM2 may also be involved in DNA binding, or perhaps is a protein-protein interaction domain.
Pssm-ID: 460214 Cd Length: 53 Bit Score: 63.02 E-value: 2.45e-12
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 112382216 286 IRVGPSHQAKLPDLQPFPSPDGDTVTQHEELVWMP--GVNDCDLLMYLRAARS 336
Cdd:pfam01448 1 IRVGPRYQAEIPELLPPSEEEDRYEEEDELLVWDPnhNLPDRKLDEYLVVARS 53
|
|
| GATA |
pfam00320 |
GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This ... |
507-542 |
1.25e-11 |
|
GATA zinc finger; This domain uses four cysteine residues to coordinate a zinc ion. This domain binds to DNA. Two GATA zinc fingers are found in the GATA transcription factors. However there are several proteins which only contain a single copy of the domain.
Pssm-ID: 425605 [Multi-domain] Cd Length: 36 Bit Score: 60.41 E-value: 1.25e-11
10 20 30
....*....|....*....|....*....|....*.
gi 112382216 507 CRHCFTTTSKDWHHGGRENILLCTDCRIHFKKYGEL 542
Cdd:pfam00320 1 CSNCGTTKTPLWRRGPNGNRTLCNACGLYYKKKGLK 36
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
540-956 |
1.49e-11 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 69.97 E-value: 1.49e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 540 GELPPIEKPVDPPPFMFKPVKEeddglsgkhSMRTRRSRGSMSTLRSGRKKQPASPDGRTSPINE--DIRSSGRNSPSAA 617
Cdd:PHA03247 2549 GDPPPPLPPAAPPAAPDRSVPP---------PRPAPRPSEPAVTSRARRPDAPPQSARPRAPVDDrgDPRGPAPPSPLPP 2619
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 618 STSSNDSKAETVKKSAKKVKEEASSPLKSNKRQREKVASDTEEADRTSSKKTKTqeiSRPNSPSEGEGESSDSRSVNDEG 697
Cdd:PHA03247 2620 DTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRA---AQASSPPQRPRRRAARPTVGSLT 2696
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 698 SS-----DPKDIDQDNRSTSPSIPSPQDNESDSDSSAQQQMLQAQPPALQAP-TGVTPAPSSAPPGTPQLPTPGPTPSAT 771
Cdd:PHA03247 2697 SLadpppPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPaTPGGPARPARPPTTAGPPAPAPPAAPA 2776
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 772 AVPPQGSPTASQAPNQPQAPTAPVPhthiqQAPALHPQRPPSPHPPPHPSPHPPLQPLTGSAGQPSAPSHAQPPLHGQGP 851
Cdd:PHA03247 2777 AGPPRRLTRPAVASLSESRESLPSP-----WDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLP 2851
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 852 PGPHSLQAGPLLQHPGPPQPFGLPPQASQGQAPLGTSPAAAYPHTSLQLPASQSALQSQQPPREQPLPPAPLAMPHIKPP 931
Cdd:PHA03247 2852 LGGSVAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQP 2931
|
410 420
....*....|....*....|....*.
gi 112382216 932 PTTPIPQLPAPQA-HKHPPHLSGPSP 956
Cdd:PHA03247 2932 PPPPPPRPQPPLApTTDPAGAGEPSG 2957
|
|
| BAH |
pfam01426 |
BAH domain; This domain has been called BAH (Bromo adjacent homology) domain and has also been ... |
103-281 |
6.30e-10 |
|
BAH domain; This domain has been called BAH (Bromo adjacent homology) domain and has also been called ELM1 and BAM (Bromo adjacent motif) domain. The function of this domain is unknown but may be involved in protein-protein interaction.
Pssm-ID: 460207 Cd Length: 120 Bit Score: 58.47 E-value: 6.30e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 103 VVYRPGDCVYIESRRPNTPYFICSIQDFKlvhnsqaccrsptpalCDPPACSLPVasqppqhlseagrgpvgskrdhllm 182
Cdd:pfam01426 1 ETYSVGDFVLVEPDDADEPYYVARIEELF----------------EDTKNGKKMV------------------------- 39
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 183 NVKWYYRQSEVPdsvyqHLVQDRHNEndsgrelvitdpviknRELFISDYVDTYHAAALRGKCNISHFSDIFAAREFK-A 261
Cdd:pfam01426 40 RVQWFYRPEETV-----HRAGKAFNK----------------DELFLSDEEDDVPLSAIIGKCSVLHKSDLESLDPYKiK 98
|
170 180
....*....|....*....|
gi 112382216 262 RVDSFFYILGYNPETRRLNS 281
Cdd:pfam01426 99 EPDDFFCELLYDPKTKSFKK 118
|
|
| BAH |
smart00439 |
Bromo adjacent homology domain; |
105-281 |
1.55e-09 |
|
Bromo adjacent homology domain;
Pssm-ID: 214664 [Multi-domain] Cd Length: 121 Bit Score: 57.30 E-value: 1.55e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 105 YRPGDCVYIESRRPNTPYFICSIQDfklvhnsqaccrsptpaLCDPPACSLPVASQppqhlseagrgpvgskrdhllmnV 184
Cdd:smart00439 2 ISVGDFVLVEPDDADEPYYIGRIEE-----------------IFETKKNSESKMVR-----------------------V 41
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 185 KWYYRQSEVPdsvyqHLVQDRHNENdsgrelvitdpviknrELFISDYVDTYHAAALRGKCNISHFSDIF--AAREFKAR 262
Cdd:smart00439 42 RWFYRPEETV-----LEKAALFDKN----------------EVFLSDEYDTVPLSDIIGKCNVLYKSDYPglRPEGSIGE 100
|
170
....*....|....*....
gi 112382216 263 VDSFFYILGYNPETRRLNS 281
Cdd:smart00439 101 PDVFFCESAYDPEKGSFKK 119
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
738-916 |
7.89e-09 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 60.38 E-value: 7.89e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 738 PPALQAPTGVTPAPSSAPPGTPQLPTPGPTPSATAVPPQGSPTASQAPNQPQAPTAPVPHTHIQQAPALHPQRPPSPHPP 817
Cdd:PRK07764 591 APGAAGGEGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWP 670
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 818 PHPSPHPPLQPLTGSAGQPSAPSHAQPPLHGQ--GPPGPHSLQA-GPLLQHPGPPQPFGLPPQASQGQAPLGTSPAA--A 892
Cdd:PRK07764 671 AKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPApaPAATPPAGQAdDPAAQPPQAAQGASAPSPAADDPVPLPPEPDDppD 750
|
170 180
....*....|....*....|....
gi 112382216 893 YPHTSLQLPASQSALQSQQPPREQ 916
Cdd:PRK07764 751 PAGAPAQPPPPPAPAPAAAPAAAP 774
|
|
| MSCRAMM_ClfA |
NF033609 |
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ... |
545-729 |
9.44e-09 |
|
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.
Pssm-ID: 468110 [Multi-domain] Cd Length: 934 Bit Score: 60.31 E-value: 9.44e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 545 IEKPVDPP----PFMFKPVKEEDDGLSGKHSMRTRRSR------GSMSTLRSGRKKQPASPDGRTSPINEDIRSSGRNSP 614
Cdd:NF033609 539 IDKPVVPEqpdePGEIEPIPEDSDSDPGSDSGSDSSNSdsgsdsGSDSTSDSGSDSASDSDSASDSDSASDSDSASDSDS 618
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 615 SAASTSSNDSKAETVKKSAKKVKEEASSPLKSNKRQREKVASDTEeADRTSSKKTKTQEISRPNSPSEGEGES-SDSRSV 693
Cdd:NF033609 619 ASDSDSASDSDSASDSDSASDSDSDSDSDSDSDSDSDSDSDSDSD-SDSDSDSDSDSDSDSDSDSDSDSDSDSdSDSDSD 697
|
170 180 190
....*....|....*....|....*....|....*.
gi 112382216 694 NDEGSSDPKDIDQDNRSTSPSiPSPQDNESDSDSSA 729
Cdd:NF033609 698 SDSDSDSDSDSDSDSDSDSDS-DSDSDSDSDSDSDS 732
|
|
| BAH |
cd04370 |
BAH, or Bromo Adjacent Homology domain (also called ELM1 and BAM for Bromo Adjacent Motif). ... |
105-277 |
8.70e-08 |
|
BAH, or Bromo Adjacent Homology domain (also called ELM1 and BAM for Bromo Adjacent Motif). BAH domains have first been described as domains found in the polybromo protein and Yeast Rsc1/Rsc2 (Remodeling of the Structure of Chromatin). They also occur in mammalian DNA methyltransferases and the MTA1 subunits of histone deacetylase complexes. A BAH domain is also found in Yeast Sir3p and in the origin receptor complex protein 1 (Orc1p), where it was found to interact with the N-terminal lobe of the silence information regulator 1 protein (Sir1p), confirming the initial hypothesis that BAH plays a role in protein-protein interactions.
Pssm-ID: 239835 [Multi-domain] Cd Length: 123 Bit Score: 52.39 E-value: 8.70e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 105 YRPGDCVYIE--SRRPNTPYFICSIQDFklvhnsqaccrsptpalcdppacslpvasqppqhlseagrgpVGSKRDHLLM 182
Cdd:cd04370 4 YEVGDSVYVEpdDSIKSDPPYIARIEEL------------------------------------------WEDTNGSKQV 41
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 183 NVKWYYRQSEVPDSVYQHlvqdrHNEndsgrelvitdpviknRELFISDYVDTYHAAALRGKCNISHFSDIF--AAREFK 260
Cdd:cd04370 42 KVRWFYRPEETPKGLSPF-----ALR----------------RELFLSDHLDEIPVESIIGKCKVLFVSEFEglKQRPNK 100
|
170
....*....|....*..
gi 112382216 261 ARVDSFFYILGYNPETR 277
Cdd:cd04370 101 IDTDDFFCRLAYDPTTK 117
|
|
| BAH_fungalPHD |
cd04710 |
BAH, or Bromo Adjacent Homology domain, as present in fungal proteins containing PHD domains. ... |
101-278 |
1.92e-07 |
|
BAH, or Bromo Adjacent Homology domain, as present in fungal proteins containing PHD domains. BAH domains are found in a variety of proteins playing roles in transcriptional silencing and the remodeling of chromatin. It is assumed that in most or all of these instances the BAH domain mediates protein-protein interactions.
Pssm-ID: 240061 Cd Length: 135 Bit Score: 51.60 E-value: 1.92e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 101 DDVVYRPGDCVYIESRRPNTPYFICSIQDFklvhnsqaccrsptpalcdppacsLPVASQPPQHLSEAGRGPVGSKRdhl 180
Cdd:cd04710 8 NGELLKVNDHIYMSSEPPGEPYYIGRIMEF------------------------VPKHEFPSGIHARVFPASYFQVR--- 60
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 181 lMNvkWYYRQSEVpdsvyqhlvqDRHNENDSgrelvitdpviknRELFISDYVDTYHAAALRGKCNISHFSDIFAAREFK 260
Cdd:cd04710 61 -LN--WYYRPRDI----------SRRVVADS-------------RLLYASMHSDICPIGSVRGKCTVRHRDQIPDLEEYK 114
|
170
....*....|....*...
gi 112382216 261 ARVDSFFYILGYNPETRR 278
Cdd:cd04710 115 KRPNHFYFDQLFDRYILR 132
|
|
| PAT1 |
pfam09770 |
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ... |
738-890 |
6.57e-07 |
|
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.
Pssm-ID: 401645 [Multi-domain] Cd Length: 846 Bit Score: 54.27 E-value: 6.57e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 738 PPALQAPTGVTPAPSSAPPGTPQLP----------------TPGPTPSATAVPPQgSPTASQAPNQPQAPTAPVPHTHIQ 801
Cdd:pfam09770 166 APKKAAAPAPAPQPAAQPASLPAPSrkmmsleeveaamraqAKKPAQQPAPAPAQ-PPAAPPAQQAQQQQQFPPQIQQQQ 244
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 802 QAPALHPQRPPSPHPPPHPSPHPPLQPLTGSAGQPSAPSHAQPPLHGQGPPGPHSLQA-----------------GPLLQ 864
Cdd:pfam09770 245 QPQQQPQQPQQHPGQGHPVTILQRPQSPQPDPAQPSIQPQAQQFHQQPPPVPVQPTQIlqnpnrlsaarvgypqnPQPGV 324
|
170 180
....*....|....*....|....*.
gi 112382216 865 HPGPPQPFGLPPQASQGQAPLGTSPA 890
Cdd:pfam09770 325 QPAPAHQAHRQQGSFGRQAPIITHPQ 350
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
542-961 |
8.20e-07 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 54.17 E-value: 8.20e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 542 LPPIEKPVDPPPFMFKPVKEEDDGLSGKHSMRTRRSRGSMSTLR---SGRKKQPASPDGRTSPINEDIRSSGRNS--PSA 616
Cdd:PHA03247 2617 LPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRvsrPRRARRLGRAAQASSPPQRPRRRAARPTvgSLT 2696
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 617 ASTSSNDSKAETVKKSAKKVKEEASSPLKSNKRQREKVASDTEEADRTSSKKTKTQEISRPNSPSEGEGESSDSRSVNDE 696
Cdd:PHA03247 2697 SLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPA 2776
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 697 GSSDPKDIDQDNRSTSPSIPSPQDNESDSDSSAQQQMLQAQPPALQAPTGVTPAPSSA---PPGTPQLPTPGPTPSATAV 773
Cdd:PHA03247 2777 AGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAqptAPPPPPGPPPPSLPLGGSV 2856
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 774 PPQGS----PTASQAPNQPQAPTAPVPHTHIQQAPALHPQRPPSPHPPPHPSPHPPLQPLTGSAGQPSAPSHAQPPLHGQ 849
Cdd:PHA03247 2857 APGGDvrrrPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPP 2936
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 850 GPPGPhslQAGPLLQHPGPPQPFGLPPQASQGQAPLGTSPA----AAYPHTSLQLPASQ--------------------- 904
Cdd:PHA03247 2937 PRPQP---PLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVprfrVPQPAPSREAPASStppltghslsrvsswasslal 3013
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 905 ---------SALQSQQPPREQPLPPAPLAMPHIKPPPTTPIPQLPAPQAHKHPPHLS-----------------GPSPFS 958
Cdd:PHA03247 3014 heetdpppvSLKQTLWPPDDTEDSDADSLFDSDSERSDLEALDPLPPEPHDPFAHEPdpatpeagarespssqfGPPPLS 3093
|
...
gi 112382216 959 MNA 961
Cdd:PHA03247 3094 ANA 3096
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
660-845 |
1.71e-06 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 53.07 E-value: 1.71e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 660 EADRTSSKKTKTQEISRPNSPSEGEGESSDSRSVNDEGSSDPKDIDQDNRSTSPSIPSPQDNESDSDSSAQQQMLQAQPP 739
Cdd:PRK07764 598 EGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAA 677
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 740 ALQAPTGVTPAPSSAPPGTPQlPTPGPTPSATAVPPQGSPTASQAPNQPQAPTAPVPHTHIQQAPALHPQRPPSPHPPPH 819
Cdd:PRK07764 678 PAAPPPAPAPAAPAAPAGAAP-AQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSPAADDPVPLPPEPDDPPDPAGAPA 756
|
170 180
....*....|....*....|....*.
gi 112382216 820 PSPHPPLQPLTGSAGQPSAPSHAQPP 845
Cdd:PRK07764 757 QPPPPPAPAPAAAPAAAPPPSPPSEE 782
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
708-1145 |
1.72e-06 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 53.02 E-value: 1.72e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 708 NRSTSPSIPSPQDNESDSDSSAQQQMLQAQPPALQAPTG------VTPAPSSAPPGTPQLPTPGPTPSATAV-PPQGSPT 780
Cdd:PHA03247 2565 DRSVPPPRPAPRPSEPAVTSRARRPDAPPQSARPRAPVDdrgdprGPAPPSPLPPDTHAPDPPPPSPSPAANePDPHPPP 2644
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 781 ASQAPNQPQAPTAP--VPHTHIQQAPALHPQRPPSPHPPPHPSPHPPLQPLTGSAGQPSAPSHAQPPLHGQGPPGPHSLQ 858
Cdd:PHA03247 2645 TVPPPERPRDDPAPgrVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPG 2724
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 859 AGPLLQ-HPGPPQPFGLPPQASQGQAPLGTSPAAAYPHTSLQLPASQSALQSQQPPREQPLPPaplamphIKPPPTTPIP 937
Cdd:PHA03247 2725 PAAARQaSPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPA-------VASLSESRES 2797
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 938 QLPAPQAHKHPPHLSGPSPFSMNANLPPPPALKPLSSLSTHHPPSAHPPPLQL--------------MPQSQPLPSSPAQ 1003
Cdd:PHA03247 2798 LPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLplggsvapggdvrrRPPSRSPAAKPAA 2877
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 1004 PPGlTQSQNLPPPPASHPPTGLHQVAPQPPFAQHPFVPGGPPPITPPTCPSTSTPPAGPGTSAQPPCSGAAASGGSIAGG 1083
Cdd:PHA03247 2878 PAR-PPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPS 2956
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 112382216 1084 SSCPLPTvqikeeaLDDAEEPESPPPPPRSPSPEPTVvdtPSHASQSARFYKHLDRGYNSCA 1145
Cdd:PHA03247 2957 GAVPQPW-------LGALVPGRVAVPRFRVPQPAPSR---EAPASSTPPLTGHSLSRVSSWA 3008
|
|
| PHA03378 |
PHA03378 |
EBNA-3B; Provisional |
739-882 |
2.88e-06 |
|
EBNA-3B; Provisional
Pssm-ID: 223065 [Multi-domain] Cd Length: 991 Bit Score: 52.38 E-value: 2.88e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 739 PALQAPTGV-TPAPSSAPPGTPQLPTPGPTPsatAVPPQGSPTASQAP---NQPQAPTAPVPHTHIQQAPALHPQRPPSP 814
Cdd:PHA03378 673 PYQPSPTGAnTMLPIQWAPGTMQPPPRAPTP---MRPPAAPPGRAQRPaaaTGRARPPAAAPGRARPPAAAPGRARPPAA 749
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 112382216 815 HPPPHPSPHPPLQPLTGSAGQPSAPSHAQPPlhgQGPPGPHSL-QAGPLLQHP--GPPQPFGLPPQASQGQ 882
Cdd:PHA03378 750 APGRARPPAAAPGRARPPAAAPGAPTPQPPP---QAPPAPQQRpRGAPTPQPPpqAGPTSMQLMPRAAPGQ 817
|
|
| PRK12323 |
PRK12323 |
DNA polymerase III subunit gamma/tau; |
680-910 |
4.93e-06 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 237057 [Multi-domain] Cd Length: 700 Bit Score: 51.42 E-value: 4.93e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 680 PSEGEGESSDSRSVNDEgSSDPKDIDQDNRSTSPSIPSPQDNESDSDSSAQQQMLQAQPPALQ--APTGVTPAPSSAPPG 757
Cdd:PRK12323 365 PGQSGGGAGPATAAAAP-VAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRspAPEALAAARQASARG 443
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 758 TPQLPTPGPTPSATAVPPQGSPTASQAPNQPQAPTAPVPHTHIQQAPALHPQRPPSPHPPPHPSPHPPLQPLTGSAGQPS 837
Cdd:PRK12323 444 PGGAPAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPWEELPPEFASPAPAQPDAAPAGWVA 523
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 838 A----PSHAQPPlhGQGPPGPHSLQAGPLLQHPGPPQPFGLPPQASQGQAPLGTSPAAAYPHTSLQLP----ASQSALQS 909
Cdd:PRK12323 524 EsipdPATADPD--DAFETLAPAPAAAPAPRAAAATEPVVAPRPPRASASGLPDMFDGDWPALAARLPvrglAQQLARQS 601
|
.
gi 112382216 910 Q 910
Cdd:PRK12323 602 E 602
|
|
| PspC_subgroup_1 |
NF033838 |
pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, ... |
557-804 |
4.95e-06 |
|
pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A. The other form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site.
Pssm-ID: 468201 [Multi-domain] Cd Length: 684 Bit Score: 51.17 E-value: 4.95e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 557 KPVKEEDDGLSGKHSMRTRRSRGSMStlrsgrkkQPASPDGRTSPINEDIRSSGRNSPSAASTSSNDSKAEtvkksAKKV 636
Cdd:NF033838 246 KEAVEKNVATSEQDKPKRRAKRGVLG--------EPATPDKKENDAKSSDSSVGEETLPSPSLKPEKKVAE-----AEKK 312
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 637 KEEAssplksnkrqrEKVASDTEEADR----TSSKKTKTQEISRPNSP-SEGE-----GESSDSRsvNDEGSSDPKDIDQ 706
Cdd:NF033838 313 VEEA-----------KKKAKDQKEEDRrnypTNTYKTLELEIAESDVKvKEAElelvkEEAKEPR--NEEKIKQAKAKVE 379
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 707 DNRSTSPSIPSPQDNESDSDSSAQQQMlqaqppALQAPTGVTPAPSSAPPGTPQLPTPGPTPSATAVPPQGSPTASQAPN 786
Cdd:NF033838 380 SKKAEATRLEKIKTDRKKAEEEAKRKA------AEEDKVKEKPAEQPQPAPAPQPEKPAPKPEKPAEQPKAEKPADQQAE 453
|
250
....*....|....*....
gi 112382216 787 QPQAPTAP-VPHTHIQQAP 804
Cdd:NF033838 454 EDYARRSEeEYNRLTQQQP 472
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
677-894 |
5.62e-06 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 51.14 E-value: 5.62e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 677 PNSPSEGEGESSDSRSVNDEGSSDPKDIDQDNRSTSPSiPSPQDNESDSDSSAQQQMLQAqPPALQAPTGVTPAPSSAPP 756
Cdd:PRK07764 591 APGAAGGEGPPAPASSGPPEEAARPAAPAAPAAPAAPA-PAGAAAAPAEASAAPAPGVAA-PEHHPKHVAVPDASDGGDG 668
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 757 GTPQLPTPGPTPSATAVPPQGSPT-ASQAPNQPQAPTAPVPHTHIQQAPAlhpqrppsphppPHPSPHPPLQPLTGSAGQ 835
Cdd:PRK07764 669 WPAKAGGAAPAAPPPAPAPAAPAApAGAAPAQPAPAPAATPPAGQADDPA------------AQPPQAAQGASAPSPAAD 736
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 112382216 836 PSAPSHAQPPLHGQGPPGPHSLQAGPllqHPGPPQPFGLPPQASQGQAPLGTSPAAAYP 894
Cdd:PRK07764 737 DPVPLPPEPDDPPDPAGAPAQPPPPP---APAPAAAPAAAPPPSPPSEEEEMAEDDAPS 792
|
|
| PRK14951 |
PRK14951 |
DNA polymerase III subunits gamma and tau; Provisional |
733-910 |
7.52e-06 |
|
DNA polymerase III subunits gamma and tau; Provisional
Pssm-ID: 237865 [Multi-domain] Cd Length: 618 Bit Score: 50.48 E-value: 7.52e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 733 MLQAQPPAlqAPTGVTPAPSSAP-PGTPQLPTPGPTPSATAVPPQGSPTASQAPNQPQAPTAPVPHTHIQQAPALHPQRP 811
Cdd:PRK14951 361 LLAFKPAA--AAEAAAPAEKKTPaRPEAAAPAAAPVAQAAAAPAPAAAPAAAASAPAAPPAAAPPAPVAAPAAAAPAAAP 438
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 812 PSPHPPPHPSPhpplqpltgSAGQPSAPSHAQPPLHGQgpPGPHSLQAGPllqHPGPPQPFGLPPQASQGQAPLGTSP-- 889
Cdd:PRK14951 439 AAAPAAVALAP---------APPAQAAPETVAIPVRVA--PEPAVASAAP---APAAAPAAARLTPTEEGDVWHATVQql 504
|
170 180
....*....|....*....|.
gi 112382216 890 AAAYPHTSLqlpASQSALQSQ 910
Cdd:PRK14951 505 AAAEAITAL---ARELALQSE 522
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
723-871 |
8.30e-06 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 50.75 E-value: 8.30e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 723 SDSDSSAQQQMLQAQPPALQAPTGVTPAPSSAPPGTPQLPTPGPTPSATAVPPQGSPTAsqapnQPQAPTAPVPHTHIQQ 802
Cdd:PRK07764 367 ASDDERGLLARLERLERRLGVAGGAGAPAAAAPSAAAAAPAAAPAPAAAAPAAAAAPAP-----AAAPQPAPAPAPAPAP 441
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 112382216 803 APALHPQRPPSPHPPPHPSPHPPLQPLTGSAGQPSAPSHAQPPLHGQGPPGPhslQAGPllQHPGPPQP 871
Cdd:PRK07764 442 PSPAGNAPAGGAPSPPPAAAPSAQPAPAPAAAPEPTAAPAPAPPAAPAPAAA---PAAP--AAPAAPAG 505
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
747-954 |
1.22e-05 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 49.98 E-value: 1.22e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 747 VTPAPSSAPPGTPQLPTPGPTPSATAVP-PQGSPTASQAPNQPQAPTAPVPHTHIQQAPALHPQRPPSPHPPPHPSPHPP 825
Cdd:PRK07764 588 VGPAPGAAGGEGPPAPASSGPPEEAARPaAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGD 667
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 826 LQPLTGSAGQPSAPSHAQPPLHGQGPPGphslQAGPLLQHPGPPQPFGLPPQASQGQAPLGTSPAAAyphtslqlpaSQS 905
Cdd:PRK07764 668 GWPAKAGGAAPAAPPPAPAPAAPAAPAG----AAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASA----------PSP 733
|
170 180 190 200
....*....|....*....|....*....|....*....|....*....
gi 112382216 906 ALQSQQPPREQPLPPAPLAMPHIKPPPTTPIPQLPAPQAHKHPPHLSGP 954
Cdd:PRK07764 734 AADDPVPLPPEPDDPPDPAGAPAQPPPPPAPAPAAAPAAAPPPSPPSEE 782
|
|
| PHA03307 |
PHA03307 |
transcriptional regulator ICP4; Provisional |
592-791 |
1.71e-05 |
|
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 49.78 E-value: 1.71e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 592 PASPDGRTSPINEDIRSSGRNSPSAASTSSNDSKAEtvKKSAKKVKEEASSPLKSnkRQREKVASDTEEADR----TSSK 667
Cdd:PHA03307 190 PAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPG--RSAADDAGASSSDSSSS--ESSGCGWGPENECPLprpaPITL 265
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 668 KTKTQEISRPNSPSEGEGESSDSRSVNDEgSSDPKDIDQDNRSTSPSiPSPQDNESDSDSSAQQQMLQAQPPALQAPTGV 747
Cdd:PHA03307 266 PTRIWEASGWNGPSSRPGPASSSSSPRER-SPSPSPSSPGSGPAPSS-PRASSSSSSSRESSSSSTSSSSESSRGAAVSP 343
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 112382216 748 TPAPSSAPPgtpqlPTPGPTPSATAVPPQGSPTASQAPNQPQAP 791
Cdd:PHA03307 344 GPSPSRSPS-----PSRPPPPADPSSPRKRPRPSRAPSSPAASA 382
|
|
| PAT1 |
pfam09770 |
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ... |
728-1013 |
1.75e-05 |
|
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.
Pssm-ID: 401645 [Multi-domain] Cd Length: 846 Bit Score: 49.65 E-value: 1.75e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 728 SAQQQMLQAQPPALQAPTGVTP--APSSAPPGTPQLPT---------PGPTPSATA------VPPQgspTASQAPNQPQA 790
Cdd:pfam09770 103 NRQQPAARAAQSSAQPPASSLPqyQYASQQSQQPSKPVrtgyekykePEPIPDLQVdaslwgVAPK---KAAAPAPAPQP 179
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 791 PTAPVPHTHIQ---------------QAPAlhpqrppsphppphpsphpplqpltgsAGQPSAPSHAQPPLHGQGPPGPH 855
Cdd:pfam09770 180 AAQPASLPAPSrkmmsleeveaamraQAKK---------------------------PAQQPAPAPAQPPAAPPAQQAQQ 232
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 856 SLQAGPLLQHPGPPQPFGLPPQASQGQAPlgtspaaayPHTSLQLPASQSALQSQQPPREQplppaplamphikpppttp 935
Cdd:pfam09770 233 QQQFPPQIQQQQQPQQQPQQPQQHPGQGH---------PVTILQRPQSPQPDPAQPSIQPQ------------------- 284
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 112382216 936 ipqlpaPQAHKHPPHLSGPSPFSMNANLPPPPALKPLssLSTHHPPSAHPPPLQLMPQSQplPSSPAQPPGLTQSQNL 1013
Cdd:pfam09770 285 ------AQQFHQQPPPVPVQPTQILQNPNRLSAARVG--YPQNPQPGVQPAPAHQAHRQQ--GSFGRQAPIITHPQQL 352
|
|
| PRK13042 |
PRK13042 |
superantigen-like protein SSL4; Reviewed; |
710-796 |
3.17e-05 |
|
superantigen-like protein SSL4; Reviewed;
Pssm-ID: 183854 [Multi-domain] Cd Length: 291 Bit Score: 47.71 E-value: 3.17e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 710 STSPSIPSPQDNESDSDSSAQQQMLQAQPPALQaPTGVTPAPSSAPPGTPQLPTPGPTPSATaVPPQGSPTASQAPNQPQ 789
Cdd:PRK13042 17 TTGVITTTTQAANATTPSSTKVEAPQSTPPSTK-VEAPQSKPNATTPPSTKVEAPQQTPNAT-TPSSTKVETPQSPTTKQ 94
|
....*..
gi 112382216 790 APTAPVP 796
Cdd:PRK13042 95 VPTEINP 101
|
|
| SANT |
smart00717 |
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains; |
396-441 |
3.89e-05 |
|
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
Pssm-ID: 197842 [Multi-domain] Cd Length: 49 Bit Score: 42.60 E-value: 3.89e-05
10 20 30 40
....*....|....*....|....*....|....*....|....*..
gi 112382216 396 WTEDEVKRFVKGLRQYG-KNFFRIRKElLPNKETGELITFYYYWKKT 441
Cdd:smart00717 4 WTEEEDELLIELVKKYGkNNWEKIAKE-LPGRTAEQCRERWRNLLKP 49
|
|
| SANT |
cd00167 |
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ... |
396-439 |
3.95e-05 |
|
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.
Pssm-ID: 238096 [Multi-domain] Cd Length: 45 Bit Score: 42.18 E-value: 3.95e-05
10 20 30 40
....*....|....*....|....*....|....*....|....*
gi 112382216 396 WTEDEVKRFVKGLRQYG-KNFFRIRKElLPNKETGELITFYYYWK 439
Cdd:cd00167 2 WTEEEDELLLEAVKKYGkNNWEKIAKE-LPGRTPKQCRERWRNLL 45
|
|
| PLN02967 |
PLN02967 |
kinase |
558-687 |
6.54e-05 |
|
kinase
Pssm-ID: 215521 [Multi-domain] Cd Length: 581 Bit Score: 47.35 E-value: 6.54e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 558 PVKEEDDGLSGKHSMRTRRSRgsmstlRSGRKKQPASPDGRTSPINEDIRssgrNSPSAASTSSNDSKAETVKKSA---K 634
Cdd:PLN02967 57 AVDEEPDENGAVSKKKPTRSV------KRATKKTVVEISEPLEEGSELVV----NEDAALDKESKKTPRRTRRKAAaasS 126
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 112382216 635 KVKEEASSPLKSNKRQREKVASDTEEADRTSSKKTKTQEISRPNSPSEGEGES 687
Cdd:PLN02967 127 DVEEEKTEKKVRKRRKVKKMDEDVEDQGSESEVSDVEESEFVTSLENESEEEL 179
|
|
| PRK12323 |
PRK12323 |
DNA polymerase III subunit gamma/tau; |
735-959 |
6.99e-05 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 237057 [Multi-domain] Cd Length: 700 Bit Score: 47.56 E-value: 6.99e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 735 QAQPPALQAPTGVTPAPSSAPPgTPQLPTPGPTPSATAVPPQGSPTASQAPNQPQAPT-APVPHTHIQQAPALHPQRPPS 813
Cdd:PRK12323 371 GAGPATAAAAPVAQPAPAAAAP-AAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSpAPEALAAARQASARGPGGAPA 449
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 814 PHPPPhpsphpplqpltgsagqPSAPSHAQPPlHGQGPPGPHSLQAGPllqhPGPPQPFGLPPQASQGQAP---LGTSPA 890
Cdd:PRK12323 450 PAPAP-----------------AAAPAAAARP-AAAGPRPVAAAAAAA----PARAAPAAAPAPADDDPPPweeLPPEFA 507
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 112382216 891 AAYPHTSLQLPASQSALQSQQPPREQPLPPAPLAMPHIKPPPTTPIPQLPAPQAHKHPPHLSGPSPFSM 959
Cdd:PRK12323 508 SPAPAQPDAAPAGWVAESIPDPATADPDDAFETLAPAPAAAPAPRAAAATEPVVAPRPPRASASGLPDM 576
|
|
| MSCRAMM_ClfA |
NF033609 |
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ... |
580-729 |
7.10e-05 |
|
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.
Pssm-ID: 468110 [Multi-domain] Cd Length: 934 Bit Score: 47.60 E-value: 7.10e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 580 SMSTLRSGRKKQPASPDGRTSPINEDIRSSGRNSPSAASTSSNDSKAETVKKSAKKVKEEASSPLKSNKRQREKVASDTE 659
Cdd:NF033609 630 SASDSDSASDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 709
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 112382216 660 -EADRTSSKKTKTQEISRPNSPSEGEGES-SDSRSVNDEGSSDPKDIDQDNRSTSPSiPSPQDNESDSDSSA 729
Cdd:NF033609 710 sDSDSDSDSDSDSDSDSDSDSDSDSDSDSdSDSDSDSDSDSDSDSDSDSDSDSDSDS-DSDSDSDSDSDSDS 780
|
|
| MSCRAMM_ClfA |
NF033609 |
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ... |
600-798 |
7.93e-05 |
|
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.
Pssm-ID: 468110 [Multi-domain] Cd Length: 934 Bit Score: 47.60 E-value: 7.93e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 600 SPINEDIRSSGRNSPSAASTSSNDSKAETVKKSAKKVKEEASSPLKSNKRQREKVASDTE-EADRTSSKKTKTQEISRPN 678
Cdd:NF033609 704 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDsDSDSDSDSDSDSDSDSDSD 783
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 679 SPSEGEGES-SDSRSVNDEGSSDPKDIDQDNRSTSPSiPSPQDNESDSDS-----SAQQQMLQAQPPALQAPTGVTPAPS 752
Cdd:NF033609 784 SDSDSDSDSdSDSDSDSDSDSDSDSDSDSDSDSDSDS-DSDSDSDSDSDSdsdsdSDSDSDSDSDSDSDSDSDSESDSNS 862
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 112382216 753 SAPPGTpqlptpgptpSATAVPPQGSPTASQAPNQPQAPTA--PVPHT 798
Cdd:NF033609 863 DSESGS----------NNNVVPPNSPKNGTNASNKNEAKDSkePLPDT 900
|
|
| MSCRAMM_ClfA |
NF033609 |
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial ... |
580-729 |
1.01e-04 |
|
MSCRAMM family adhesin clumping factor ClfA; Clumping factor A is an MSCRAMM (Microbial Surface Components Recognizing Adhesive Matrix Molecules). It is heavily studied in Staphylococcus aureus both for its biological role in adhesion and for its potential for vaccination. Features of the sequence, but also of other MSCRAMM adhesins, include a long run of Ser-Asp dipeptide repeats and a C-terminal cell wall anchoring LPXTG motif.
Pssm-ID: 468110 [Multi-domain] Cd Length: 934 Bit Score: 47.21 E-value: 1.01e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 580 SMSTLRSGRKKQPASPDGRTSPINEDIRSSGRNSPSAASTSSNDSKAETVKKSAKKVKEEASSPLKSNKRQREKVASDTE 659
Cdd:NF033609 650 SDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSDSD 729
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 112382216 660 -EADRTSSKKTKTQEISRPNSPSEGEGES---SDSRSVNDEGSSDPKDIDQDNRSTSPSiPSPQDNESDSDSSA 729
Cdd:NF033609 730 sDSDSDSDSDSDSDSDSDSDSDSDSDSDSdsdSDSDSDSDSDSDSDSDSDSDSDSDSDS-DSDSDSDSDSDSDS 802
|
|
| PRK10856 |
PRK10856 |
cytoskeleton protein RodZ; |
686-790 |
1.02e-04 |
|
cytoskeleton protein RodZ;
Pssm-ID: 236776 [Multi-domain] Cd Length: 331 Bit Score: 46.17 E-value: 1.02e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 686 ESSDSRSVNDEGSSDPKDIDQDNRSTSPSIPSPQDNESDSDSSAQQQMLQAQPPALQAPTGVTPAPSSAPPGTPQLPTPG 765
Cdd:PRK10856 149 QSSAELSQNSGQSVPLDTSTTTDPATTPAPAAPVDTTPTNSQTPAVATAPAPAVDPQQNAVVAPSQANVDTAATPAPAAP 228
|
90 100
....*....|....*....|....*
gi 112382216 766 PTPSATAVPPQGSPTASQAPNQPQA 790
Cdd:PRK10856 229 ATPDGAAPLPTDQAGVSTPAADPNA 253
|
|
| Myb_DNA-binding |
pfam00249 |
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ... |
396-439 |
1.04e-04 |
|
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.
Pssm-ID: 459731 [Multi-domain] Cd Length: 46 Bit Score: 40.95 E-value: 1.04e-04
10 20 30 40
....*....|....*....|....*....|....*....|....
gi 112382216 396 WTEDEVKRFVKGLRQYGKNFFRIrKELLPNKETGELITFYYYWK 439
Cdd:pfam00249 4 WTPEEDELLLEAVEKLGNRWKKI-AKLLPGRTDNQCKNRWQNYL 46
|
|
| PAT1 |
pfam09770 |
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ... |
709-906 |
2.34e-04 |
|
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.
Pssm-ID: 401645 [Multi-domain] Cd Length: 846 Bit Score: 45.80 E-value: 2.34e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 709 RSTSPSIPSPQDNESDSDSSAQQQMLQAQPPALQAPTGVTPAPSSAPPGTPQLPTPGPTPSATAVPPQGSPTASQAPNQP 788
Cdd:pfam09770 204 RAQAKKPAQQPAPAPAQPPAAPPAQQAQQQQQFPPQIQQQQQPQQQPQQPQQHPGQGHPVTILQRPQSPQPDPAQPSIQP 283
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 789 -------QAPTAPVPHTHIQQapalhpqrppsphppphpsphpplqpltgsagQPSAPSHAQPPLHGQGPPGPHslqagP 861
Cdd:pfam09770 284 qaqqfhqQPPPVPVQPTQILQ--------------------------------NPNRLSAARVGYPQNPQPGVQ-----P 326
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 112382216 862 LLQHPGPPQPFGLPPQAsqgqaplgtsPAAAYPHTSLQLPASQSA 906
Cdd:pfam09770 327 APAHQAHRQQGSFGRQA----------PIITHPQQLAQLSEEEKA 361
|
|
| PTZ00108 |
PTZ00108 |
DNA topoisomerase 2-like protein; Provisional |
536-708 |
3.22e-04 |
|
DNA topoisomerase 2-like protein; Provisional
Pssm-ID: 240271 [Multi-domain] Cd Length: 1388 Bit Score: 45.42 E-value: 3.22e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 536 FKKYGELPPIEKPVDPPPFMFKPVKEEDDglSGKHSMRTRRSRGSMSTLRSGRKKQPASPDGRTSPINedirSSGRNSPS 615
Cdd:PTZ00108 1223 SDQEDDEEQKTKPKKSSVKRLKSKKNNSS--KSSEDNDEFSSDDLSKEGKPKNAPKRVSAVQYSPPPP----SKRPDGES 1296
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 616 AASTSSNDSKAETVKKSAKKVKEEASSPLKSNKRQREKVASDTEEADRTSSKKTKTQEISRPNSPSEGEgESSDSRSVND 695
Cdd:PTZ00108 1297 NGGSKPSSPTKKKVKKRLEGSLAALKKKKKSEKKTARKKKSKTRVKQASASQSSRLLRRPRKKKSDSSS-EDDDDSEVDD 1375
|
170
....*....|...
gi 112382216 696 EGSSDPKDIDQDN 708
Cdd:PTZ00108 1376 SEDEDDEDDEDDD 1388
|
|
| kgd |
PRK12270 |
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ... |
691-805 |
4.61e-04 |
|
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;
Pssm-ID: 237030 [Multi-domain] Cd Length: 1228 Bit Score: 44.88 E-value: 4.61e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 691 RSVNDEGSSDPK--DIDQDNRSTSPSIPSPQDNESDSDSSAQqqmlqaqPPALQAPTGVTPAPSSAPPGTPQlPTPGPTP 768
Cdd:PRK12270 17 QYLADPNSVDPSwrEFFADYGPGSTAAPTAAAAAAAAAASAP-------AAAPAAKAPAAPAPAPPAAAAPA-APPKPAA 88
|
90 100 110
....*....|....*....|....*....|....*..
gi 112382216 769 SATAVPPQGSPTASQAPNQPQAPTAPVPHTHIQQAPA 805
Cdd:PRK12270 89 AAAAAAAPAAPPAAAAAAAPAAAAVEDEVTPLRGAAA 125
|
|
| PHA03264 |
PHA03264 |
envelope glycoprotein D; Provisional |
698-800 |
5.99e-04 |
|
envelope glycoprotein D; Provisional
Pssm-ID: 223029 [Multi-domain] Cd Length: 416 Bit Score: 44.23 E-value: 5.99e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 698 SSDPKDIDQDNRSTSPSIPSPQDNESDSDSSAQQQmlqAQPPALQAPTGVTPAPSSAPPGTPQLPTPGPT-PSATAVPPQ 776
Cdd:PHA03264 260 ESKGYEPPPAPSGGSPAPPGDDRPEAKPEPGPVED---GAPGRETGGEGEGPEPAGRDGAAGGEPKPGPPrPAPDADRPE 336
|
90 100
....*....|....*....|....
gi 112382216 777 GSPTASQAPNQPQAPTAPVPHTHI 800
Cdd:PHA03264 337 GWPSLEAITFPPPTPATPAVPRAR 360
|
|
| PRK14971 |
PRK14971 |
DNA polymerase III subunit gamma/tau; |
691-788 |
6.81e-04 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 237874 [Multi-domain] Cd Length: 614 Bit Score: 44.38 E-value: 6.81e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 691 RSVNDEGSSDPKDIDQDNRSTSPSIPSPQDNESDSDSSAQQQMLQAQPPAlqAPTGVTPAPSSAPPGTPQLPTPGPTPSA 770
Cdd:PRK14971 363 TQKGDDASGGRGPKQHIKPVFTQPAAAPQPSAAAAASPSPSQSSAAAQPS--APQSATQPAGTPPTVSVDPPAAVPVNPP 440
|
90
....*....|....*...
gi 112382216 771 TAVPPQGSPTASQAPNQP 788
Cdd:PRK14971 441 STAPQAVRPAQFKEEKKI 458
|
|
| Med15 |
pfam09606 |
ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of ... |
725-1038 |
6.81e-04 |
|
ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of the ARC-Mediator co-activator is a three-helix bundle with marked similarity to the KIX domain. The sterol regulatory element binding protein (SREBP) family of transcription activators use the ARC105 subunit to activate target genes in the regulation of cholesterol and fatty acid homeostasis. In addition, Med15 is a critical transducer of gene activation signals that control early metazoan development.
Pssm-ID: 312941 [Multi-domain] Cd Length: 732 Bit Score: 44.23 E-value: 6.81e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 725 SDSSAQQQMLQAQPPAlQAPTGVTPAPSSAPPGTPQLPTPGPTPSA----TAVPPQGSPTASQAPNQPQAPTAPVPHTHI 800
Cdd:pfam09606 138 GFPSQMSRVGRMQPGG-QAGGMMQPSSGQPGSGTPNQMGPNGGPGQgqagGMNGGQQGPMGGQMPPQMGVPGMPGPADAG 216
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 801 QQAPALHPQRPPSPHPPphpsphpplqpltGSAGQPSAPSHAQPPLHgQGPPGPHSLQAGPLLQHPGPPQPFGLPPQASQ 880
Cdd:pfam09606 217 AQMGQQAQANGGMNPQQ-------------MGGAPNQVAMQQQQPQQ-QGQQSQLGMGINQMQQMPQGVGGGAGQGGPGQ 282
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 881 GQAPLGTSPAAAYPHTSLQLPASQSALQSQQPPREQPLPPaplamphikpppttpipqlpaPQAHKHPPHLSGPSPFSMN 960
Cdd:pfam09606 283 PMGPPGQQPGAMPNVMSIGDQNNYQQQQTRQQQQQQGGNH---------------------PAAHQQQMNQSVGQGGQVV 341
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 112382216 961 AnlppppaLKPLSSLSTHHPPSAHPPPLQLMPQSQPLPSSPAQPPGLTQSQNLPPPPASHPPTGLHQVAPQPPFAQHP 1038
Cdd:pfam09606 342 A-------LGGLNHLETWNPGNFGGLGANPMQRGQPGMMSSPSPVPGQQVRQVTPNQFMRQSPQPSVPSPQGPGSQPP 412
|
|
| PRK10856 |
PRK10856 |
cytoskeleton protein RodZ; |
729-838 |
8.43e-04 |
|
cytoskeleton protein RodZ;
Pssm-ID: 236776 [Multi-domain] Cd Length: 331 Bit Score: 43.48 E-value: 8.43e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 729 AQQQMLQA---QPPALQAPTGVTPAPSSAPPGTPQLPTPGPTPSATAVPPQGSPTASQAPNQPQAP---TAPVPHTHIQQ 802
Cdd:PRK10856 138 AQQEEITTmadQSSAELSQNSGQSVPLDTSTTTDPATTPAPAAPVDTTPTNSQTPAVATAPAPAVDpqqNAVVAPSQANV 217
|
90 100 110
....*....|....*....|....*....|....*.
gi 112382216 803 APALHPQRPPSPHPPPHPSPHPPLQPLTGSAGQPSA 838
Cdd:PRK10856 218 DTAATPAPAAPATPDGAAPLPTDQAGVSTPAADPNA 253
|
|
| PHA03169 |
PHA03169 |
hypothetical protein; Provisional |
571-798 |
8.48e-04 |
|
hypothetical protein; Provisional
Pssm-ID: 223003 [Multi-domain] Cd Length: 413 Bit Score: 43.81 E-value: 8.48e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 571 SMRTRRSRGSMSTLRSGRKKQPASPDGRTspinEDIRSSGRNSPSAASTSSNDSKAETVKKSAKKVKEEASSPLKSNKRQ 650
Cdd:PHA03169 2 SRQRRKAKRSRHTLRSSCRGHCKRHGGTR----EQAGRRRGTAARAAKPAPPAPTTSGPQVRAVAEQGHRQTESDTETAE 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 651 REKVASDTEEADRTSSKKTKTQEISRPNSPSE-GEGESSDSRSVNDEGSSDPKDIDQDNRSTSPSIP---SPQDNESDSD 726
Cdd:PHA03169 78 ESRHGEKEERGQGGPSGSGSESVGSPTPSPSGsAEELASGLSPENTSGSSPESPASHSPPPSPPSHPgphEPAPPESHNP 157
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 112382216 727 SSAQQQMLQAQPPALQAPTGVTPAPSSAPPGTPQlptPGPTPSATAVPPQGSPTASQAPNQ-PQAPTAPVPHT 798
Cdd:PHA03169 158 SPNQQPSSFLQPSHEDSPEEPEPPTSEPEPDSPG---PPQSETPTSSPPPQSPPDEPGEPQsPTPQQAPSPNT 227
|
|
| PHA03307 |
PHA03307 |
transcriptional regulator ICP4; Provisional |
543-892 |
1.17e-03 |
|
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 43.62 E-value: 1.17e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 543 PPIEKPVDPPPfmfKPVKEEDDGLSGKHSMRTRRSRGSMSTLRSGRKKQPASPDGRTSPINEDIRSSGRNSPSAASTSSN 622
Cdd:PHA03307 63 DRFEPPTGPPP---GPGTEAPANESRSTPTWSLSTLAPASPAREGSPTPPGPSSPDPPPPTPPPASPPPSPAPDLSEMLR 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 623 DSKAETVKKSAKKVKEEASSPLK----SNKRQREKVASDTEEADRTSSKKTKTQEISRPN---SPSEGEGESSDSRSVND 695
Cdd:PHA03307 140 PVGSPGPPPAASPPAAGASPAAVasdaASSRQAALPLSSPEETARAPSSPPAEPPPSTPPaaaSPRPPRRSSPISASASS 219
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 696 EGSSDPKDIDQDNRSTSPSIPSPQDNESDSDSsaqqqmLQAQPPALQAPTGVTPAPSSAPPGTPQLPTPGPTPSATAVPP 775
Cdd:PHA03307 220 PAPAPGRSAADDAGASSSDSSSSESSGCGWGP------ENECPLPRPAPITLPTRIWEASGWNGPSSRPGPASSSSSPRE 293
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 776 QGSPTASQAPNQPQAPTAPvphthiqqapalhpqrppsphppphpspHPPLQPLTGSAGQPSAPSHAQPPLHGQGPPGPH 855
Cdd:PHA03307 294 RSPSPSPSSPGSGPAPSSP----------------------------RASSSSSSSRESSSSSTSSSSESSRGAAVSPGP 345
|
330 340 350
....*....|....*....|....*....|....*..
gi 112382216 856 SLQAGPLLQHPGPPQPFGLPPQASQGQAPLGTSPAAA 892
Cdd:PHA03307 346 SPSRSPSPSRPPPPADPSSPRKRPRPSRAPSSPAASA 382
|
|
| PRK07994 |
PRK07994 |
DNA polymerase III subunits gamma and tau; Validated |
739-913 |
1.49e-03 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236138 [Multi-domain] Cd Length: 647 Bit Score: 43.32 E-value: 1.49e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 739 PALQAPTGVTPAPSSAPPGTPQLPtpgPTPSATAVPPQGSPTASQAPNQPQAPTAPVPHTHIQQAPALHPQRPpsphppp 818
Cdd:PRK07994 361 PAAPLPEPEVPPQSAAPAASAQAT---AAPTAAVAPPQAPAVPPPPASAPQQAPAVPLPETTSQLLAARQQLQ------- 430
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 819 hpsphpplqpltgSAGQPSAPSHAQPPLHGQGPPGPHSLQagPLLQHPGPPQPFGLPPQASQGQAPLGTSPAAAYPHTSL 898
Cdd:PRK07994 431 -------------RAQGATKAKKSEPAAASRARPVNSALE--RLASVRPAPSALEKAPAKKEAYRWKATNPVEVKKEPVA 495
|
170
....*....|....*
gi 112382216 899 QLPASQSALQSQQPP 913
Cdd:PRK07994 496 TPKALKKALEHEKTP 510
|
|
| PRK07994 |
PRK07994 |
DNA polymerase III subunits gamma and tau; Validated |
713-796 |
1.80e-03 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236138 [Multi-domain] Cd Length: 647 Bit Score: 42.93 E-value: 1.80e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 713 PSIPSPQDNESD----SDSSAQQQMLQAQPPALQAPTGVTPAPSSAPPGTPQLPTPGPTPSATAVPPQGSPTASQAPNQP 788
Cdd:PRK07994 361 PAAPLPEPEVPPqsaaPAASAQATAAPTAAVAPPQAPAVPPPPASAPQQAPAVPLPETTSQLLAARQQLQRAQGATKAKK 440
|
....*...
gi 112382216 789 QAPTAPVP 796
Cdd:PRK07994 441 SEPAAASR 448
|
|
| PABP-1234 |
TIGR01628 |
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ... |
756-916 |
2.16e-03 |
|
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.
Pssm-ID: 130689 [Multi-domain] Cd Length: 562 Bit Score: 42.49 E-value: 2.16e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 756 PGTPQLPTPGPTPSATAVPPQGSPtasqapnQPQAPTAPVPHTHIQQAPalhpqrppsphppphpsphpplqplTGSAGQ 835
Cdd:TIGR01628 380 PRMRQLPMGSPMGGAMGQPPYYGQ-------GPQQQFNGQPLGWPRMSM-------------------------MPTPMG 427
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 836 PSAPSHAQ--PPLHGQGPPGPHSLQAgpllQHPGPPQPFGLPPQASQGQAPLGTSPAAAYPHTSLQLPASQSALQSqQPP 913
Cdd:TIGR01628 428 PGGPLRPNglAPMNAVRAPSRNAQNA----AQKPPMQPVMYPPNYQSLPLSQDLPQPQSTASQGGQNKKLAQVLAS-ATP 502
|
...
gi 112382216 914 REQ 916
Cdd:TIGR01628 503 QMQ 505
|
|
| COG5373 |
COG5373 |
Uncharacterized membrane protein [Function unknown]; |
728-805 |
2.17e-03 |
|
Uncharacterized membrane protein [Function unknown];
Pssm-ID: 444140 [Multi-domain] Cd Length: 854 Bit Score: 42.68 E-value: 2.17e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 112382216 728 SAQQQMLQAQPPAlqAPTGVTPAPSSAPPGTPQLPTPGPTPSATAVPPQGSPTASQAPNQPQAPTAPVPhthiQQAPA 805
Cdd:COG5373 31 EELEAELAEAAEA--ASAPAEPEPEAAAAATAAAPEAAPAPVPEAPAAPPAAAEAPAPAAAAPPAEAEP----AAAPA 102
|
|
| PRK08581 |
PRK08581 |
amidase domain-containing protein; |
603-763 |
2.53e-03 |
|
amidase domain-containing protein;
Pssm-ID: 236304 [Multi-domain] Cd Length: 619 Bit Score: 42.47 E-value: 2.53e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 603 NEDIRSSGRNSPSAASTSSNDSKAETVKKSAKKvkeeassplksNKRQREKVASDTEEADRTSSKKTKTQEISRPNSPSe 682
Cdd:PRK08581 136 YEQPRNSEKSTNDSNKNSDSSIKNDTDTQSSKQ-----------DKADNQKAPSSNNTKPSTSNKQPNSPKPTQPNQSN- 203
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 683 gegesSDSRSVNDEGSsdpKDIDQDNRSTSPS-IPSPQDNESDsDSSAQQQMLQAQppalqaptGVTPAPSSAPPGTPQL 761
Cdd:PRK08581 204 -----SQPASDDTANQ---KSSSKDNQSMSDSaLDSILDQYSE-DAKKTQKDYASQ--------SKKDKTETSNTKNPQL 266
|
..
gi 112382216 762 PT 763
Cdd:PRK08581 267 PT 268
|
|
| SEEEED |
pfam14797 |
Serine-rich region of AP3B1, clathrin-adaptor complex; This short low-complexity, highly ... |
617-728 |
2.72e-03 |
|
Serine-rich region of AP3B1, clathrin-adaptor complex; This short low-complexity, highly serine-rich region lies on clathrin-adaptor complex 3 beta-1 subunit proteins, between family Adaptin_N, pfam01602 and a C-terminal domain, AP3B1_C,pfam14796.
Pssm-ID: 434218 [Multi-domain] Cd Length: 111 Bit Score: 39.14 E-value: 2.72e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 617 ASTSSNDSKAETVKKSAKKVKEEASSplksnkrqrekvasdtEEADRTSSKKTKTQeisrpnSPSEGEGESSDSRSVNDE 696
Cdd:pfam14797 15 SSDSSSDSESESGSESEEEGKEGSSS----------------EDSSEDSSSEQESE------SGSESEKKRTAKRNSKAK 72
|
90 100 110
....*....|....*....|....*....|..
gi 112382216 697 GSSDPKDIDQDNRSTSPSIPSPQDNESDSDSS 728
Cdd:pfam14797 73 GKSDSEDGEKKNEKSKTSDSSDTESSSSEESS 104
|
|
| PRK07003 |
PRK07003 |
DNA polymerase III subunit gamma/tau; |
697-805 |
2.88e-03 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 235906 [Multi-domain] Cd Length: 830 Bit Score: 42.53 E-value: 2.88e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 697 GSSDPKDIDQDNRSTSPSIPSPQDNESDSDSSAQQQMLQAQPPALQAPTgVTPAPSSAPPGT--PQLPTPGPTPSAT-AV 773
Cdd:PRK07003 429 APAPPATADRGDDAADGDAPVPAKANARASADSRCDERDAQPPADSGSA-SAPASDAPPDAAfePAPRAAAPSAATPaAV 507
|
90 100 110
....*....|....*....|....*....|..
gi 112382216 774 PPQGSPTASQAPNQPQAPTAPVPHTHiQQAPA 805
Cdd:PRK07003 508 PDARAPAAASREDAPAAAAPPAPEAR-PPTPA 538
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
716-805 |
2.88e-03 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 42.28 E-value: 2.88e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 716 PSPQDNESDSDSSAQQQMLQAQPPALQAPTGVTPAPSSAPPGTPQLPTPGPTPSATAVPPQGSPTASQAPNQPQAPTAPV 795
Cdd:PRK07764 410 PAPAAAAPAAAAAPAPAAAPQPAPAPAPAPAPPSPAGNAPAGGAPSPPPAAAPSAQPAPAPAAAPEPTAAPAPAPPAAPA 489
|
90
....*....|
gi 112382216 796 PHTHiQQAPA 805
Cdd:PRK07764 490 PAAA-PAAPA 498
|
|
| PRK10263 |
PRK10263 |
DNA translocase FtsK; Provisional |
739-914 |
3.32e-03 |
|
DNA translocase FtsK; Provisional
Pssm-ID: 236669 [Multi-domain] Cd Length: 1355 Bit Score: 42.38 E-value: 3.32e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 739 PALQAPTGVTPAPSSAPPGTPQLPTPgPTPSATAVP--PQGSPTASQAPNQPQAPTAPVPHTHiQQAPALHPQRPPSPHP 816
Cdd:PRK10263 319 PVAVAAAATTATQSWAAPVEPVTQTP-PVASVDVPPaqPTVAWQPVPGPQTGEPVIAPAPEGY-PQQSQYAQPAVQYNEP 396
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 817 PPHPSPHPPLQPLTGSAGQPSAPSHAQPPLHGQGPPGPhslqaGPLLQHPGPPQPFGLPPQASQGQAPLGTSPAAAYPHT 896
Cdd:PRK10263 397 LQQPVQPQQPYYAPAAEQPAQQPYYAPAPEQPAQQPYY-----APAPEQPVAGNAWQAEEQQSTFAPQSTYQTEQTYQQP 471
|
170
....*....|....*...
gi 112382216 897 SLQLPASQSALQSQQPPR 914
Cdd:PRK10263 472 AAQEPLYQQPQPVEQQPV 489
|
|
| PRK10856 |
PRK10856 |
cytoskeleton protein RodZ; |
717-805 |
3.53e-03 |
|
cytoskeleton protein RodZ;
Pssm-ID: 236776 [Multi-domain] Cd Length: 331 Bit Score: 41.55 E-value: 3.53e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 717 SPQDNES---DSDSSAQQQMLQAQPPALQAptgvTPAPSSAPPGTPQlPTPGPTPSATAVPPQGSptASQAPNQPQAPTA 793
Cdd:PRK10856 155 SQNSGQSvplDTSTTTDPATTPAPAAPVDT----TPTNSQTPAVATA-PAPAVDPQQNAVVAPSQ--ANVDTAATPAPAA 227
|
90
....*....|..
gi 112382216 794 PVPHTHIQQAPA 805
Cdd:PRK10856 228 PATPDGAAPLPT 239
|
|
| PRK07994 |
PRK07994 |
DNA polymerase III subunits gamma and tau; Validated |
735-869 |
6.50e-03 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236138 [Multi-domain] Cd Length: 647 Bit Score: 41.00 E-value: 6.50e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 735 QAQPPALQAPTGVTPAPSSAPPGTPQLPTPGPTPSATAVPPQGSPT--ASQAPNQPQAPTAPVPHTHIQQAPALHPQRPP 812
Cdd:PRK07994 374 SAAPAASAQATAAPTAAVAPPQAPAVPPPPASAPQQAPAVPLPETTsqLLAARQQLQRAQGATKAKKSEPAAASRARPVN 453
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 112382216 813 SPHPPPHPSPHPPLQPLTGSAGQPSAPSHAQPPLHGQGPPGPHSLQAGPLLQHPGPP 869
Cdd:PRK07994 454 SALERLASVRPAPSALEKAPAKKEAYRWKATNPVEVKKEPVATPKALKKALEHEKTP 510
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
737-1292 |
7.88e-03 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 41.08 E-value: 7.88e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 737 QPPALQAPTGVTPAP---SSAPPGTPQLPTPG-PTPSATAVPPQGSPTASQ-----------APNQPQAPTAPVPhthiq 801
Cdd:PHA03247 2482 RPAEARFPFAAGAAPdpgGGGPPDPDAPPAPSrLAPAILPDEPVGEPVHPRmltwirgleelASDDAGDPPPPLP----- 2556
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 802 qaPALHPQRPPSPHPPPHPSPHPPLQPLTGSAGQPSAPSHAQPPLHGQGPPGPHslqagpllqhPGPPQPFGLPPQAsqg 881
Cdd:PHA03247 2557 --PAAPPAAPDRSVPPPRPAPRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDP----------RGPAPPSPLPPDT--- 2621
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 882 qAPLGTSPAAAYPHTSLqlPASQSALQSQQPPREQPLPPAPLAMPHIKPPPTTPIPQLPAPQAHKHPPHLSGP-SPFSMN 960
Cdd:PHA03247 2622 -HAPDPPPPSPSPAANE--PDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTvGSLTSL 2698
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 961 ANLPPppalkplsslsthhppsahppplqlmPQSQPLPSSPAQPPGLTQSQNLPPPPASHPPTGLHQVAPQPPFAQ-HPF 1039
Cdd:PHA03247 2699 ADPPP--------------------------PPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPaTPG 2752
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 1040 VPGGPPPITPPTCPSTSTPPAGPGTSAqPPCSGAAASGGSIAGGSSCPLPTVQIKEEALDDAEEPESPPPPPRSPSPEPT 1119
Cdd:PHA03247 2753 GPARPARPPTTAGPPAPAPPAAPAAGP-PRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPP 2831
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 1120 VVDTP-SHASQSARFYKHLDRGYNSCARTDLYFMPLAGSKLAKKREEAIEKAKREAEQKAREEREREKEKEKERERERER 1198
Cdd:PHA03247 2832 TSAQPtAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQP 2911
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 1199 EREAERAAKASSSAHEgrLSDPQLSGPGhmRPSFEPPPTTIAAVPPYIGPDTPALR----TLSEYARPHVMSPTNRNhPF 1274
Cdd:PHA03247 2912 QAPPPPQPQPQPPPPP--QPQPPPPPPP--RPQPPLAPTTDPAGAGEPSGAVPQPWlgalVPGRVAVPRFRVPQPAP-SR 2986
|
570
....*....|....*...
gi 112382216 1275 YMPLNPTDPLLAYHMPGL 1292
Cdd:PHA03247 2987 EAPASSTPPLTGHSLSRV 3004
|
|
| PRK13729 |
PRK13729 |
conjugal transfer pilus assembly protein TraB; Provisional |
722-804 |
8.06e-03 |
|
conjugal transfer pilus assembly protein TraB; Provisional
Pssm-ID: 184281 [Multi-domain] Cd Length: 475 Bit Score: 40.58 E-value: 8.06e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 722 ESDSDSSAQQQMLQAQPPALQAPTGvTPAPSSAPPGTPQLPTPGPTPSATAVPPQGSPT-ASQAPNQPQAPTAPVPHTHI 800
Cdd:PRK13729 108 KLGQDNAALAEQVKALGANPVTATG-EPVPQMPASPPGPEGEPQPGNTPVSFPPQGSVAvPPPTAFYPGNGVTPPPQVTY 186
|
....
gi 112382216 801 QQAP 804
Cdd:PRK13729 187 QSVP 190
|
|
| PRK14950 |
PRK14950 |
DNA polymerase III subunits gamma and tau; Provisional |
711-796 |
8.48e-03 |
|
DNA polymerase III subunits gamma and tau; Provisional
Pssm-ID: 237864 [Multi-domain] Cd Length: 585 Bit Score: 40.56 E-value: 8.48e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 711 TSPSIPSPQDNESDSDSSAQQQMLQAQPPALQAPTGVTPAPSSAPPGTPqlPTPGPTPSATAVP---PQGSPTASQAPNQ 787
Cdd:PRK14950 361 VPVPAPQPAKPTAAAPSPVRPTPAPSTRPKAAAAANIPPKEPVRETATP--PPVPPRPVAPPVPhtpESAPKLTRAAIPV 438
|
....*....
gi 112382216 788 PQAPTAPVP 796
Cdd:PRK14950 439 DEKPKYTPP 447
|
|
| PHA03307 |
PHA03307 |
transcriptional regulator ICP4; Provisional |
658-1006 |
9.42e-03 |
|
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 40.92 E-value: 9.42e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 658 TEEADRTSSKKTKTQEISRPNSPSEGEGESSDSRSVNDEGSSDPKDIDQDNRSTSPSIPSPQDNESDSDSSAQQQMLQAQ 737
Cdd:PHA03307 77 TEAPANESRSTPTWSLSTLAPASPAREGSPTPPGPSSPDPPPPTPPPASPPPSPAPDLSEMLRPVGSPGPPPAASPPAAG 156
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 738 PPALQAPTGVTPAPSSAPPgTPQLPTPGPTPSATAVPPQGSPTASQAPNQPQAPTAPVPHTHIQQAPALHPQRPPSPHPP 817
Cdd:PHA03307 157 ASPAAVASDAASSRQAALP-LSSPEETARAPSSPPAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGAS 235
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 818 PHPSPHPPLQP----LTGSAGQPSAPSHAQPPLHGQGPPGPHSLQAGPLLQHPGPPQPFGLPPQASQGQAPLGTSPAAAY 893
Cdd:PHA03307 236 SSDSSSSESSGcgwgPENECPLPRPAPITLPTRIWEASGWNGPSSRPGPASSSSSPRERSPSPSPSSPGSGPAPSSPRAS 315
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 112382216 894 PHTSLQLPASQSALQSQQPPREQPLPPAPLAMPHIKPPPTTPIPQLPAPQAHKHPPHLSGPSP----------------- 956
Cdd:PHA03307 316 SSSSSSRESSSSSTSSSSESSRGAAVSPGPSPSRSPSPSRPPPPADPSSPRKRPRPSRAPSSPaasagrptrrraraava 395
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 112382216 957 ---FSMNANLPPPPALKPLSSLSTHHPPSAHPPPLQL-MPQSQPLPSSPAQPPG 1006
Cdd:PHA03307 396 graRRRDATGRFPAGRPRPSPLDAGAASGAFYARYPLlTPSGEPWPGSPPPPPG 449
|
|
| |
