NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|254675324|ref|NP_035299|]
View 

prolactin receptor isoform 1 precursor [Mus musculus]

Protein Classification

fibronectin type III domain-containing protein( domain architecture ID 10414115)

fibronectin type III (FN3) domain-containing protein may be involved in specific interactions with other molecules through its FN3 domain

Gene Ontology:  GO:0005515
PubMed:  8981327

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
FN3 super family cl21522
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 18-115 3.03e-33

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


The actual alignment was detected with superfamily member pfam09067:

Pssm-ID: 473895  Cd Length: 104  Bit Score: 122.53  E-value: 3.03e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675324   18 NGQSPPGKPEIHKCRSPDKETFTCWWNPGSDGGLPTNYSLTYSKEGEkNTYECPDYKTSGPNS-----CFFSKQYTSIWK 92
Cdd:pfam09067   3 AALLLPEKPEDIKCFSREKEDFTCFWEEEEDGGLPTTYSFSYAYENE-TVKECPLYSTSGANStrlfiCFFPKNDVSLFV 81

                          90       100
                  ....*....|....*....|...
gi 254675324   93 IYIITVNATNEMGSSTSDPLYVD 115
Cdd:pfam09067  82 PLHITVVATNTNGTRYSRELSVE 104
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 122-219 1.45e-06

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 46.72  E-value: 1.45e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675324 122 PEPPRNLTLEVkqlkDKKTYLWVKWLPPTitdvKTGWFTMEYEIRLKSEEADEWEIHFT--GHQTQFKVFDLYPGQKYLV 199
Cdd:cd00063    1 PSPPTNLRVTD----VTSTSVTLSWTPPE----DDGGPITGYVVEYREKGSGDWKEVEVtpGSETSYTLTGLKPGTEYEF 72

                         90       100
                 ....*....|....*....|
gi 254675324 200 QTRCKPDHGyWSRWGQEKSI 219
Cdd:cd00063   73 RVRAVNGGG-ESPPSESVTV 91
 
Name Accession Description Interval E-value
EpoR_lig-bind pfam09067
Erythropoietin receptor, ligand binding; Members of this family interact with erythropoietin ...
 18-115 3.03e-33

Erythropoietin receptor, ligand binding; Members of this family interact with erythropoietin (EPO), with subsequent initiation of the downstream chain of events associated with binding of EPO to the receptor, including EPO-induced erythroblast proliferation and differentiation through induction of the JAK2/STAT5 signaling cascade. The domain adopts a secondary structure composed of a short amino-terminal helix, followed by two beta-sandwich regions.


Pssm-ID: 401127  Cd Length: 104  Bit Score: 122.53  E-value: 3.03e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675324   18 NGQSPPGKPEIHKCRSPDKETFTCWWNPGSDGGLPTNYSLTYSKEGEkNTYECPDYKTSGPNS-----CFFSKQYTSIWK 92
Cdd:pfam09067   3 AALLLPEKPEDIKCFSREKEDFTCFWEEEEDGGLPTTYSFSYAYENE-TVKECPLYSTSGANStrlfiCFFPKNDVSLFV 81

                          90       100
                  ....*....|....*....|...
gi 254675324   93 IYIITVNATNEMGSSTSDPLYVD 115
Cdd:pfam09067  82 PLHITVVATNTNGTRYSRELSVE 104
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 122-219 1.45e-06

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 46.72  E-value: 1.45e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675324 122 PEPPRNLTLEVkqlkDKKTYLWVKWLPPTitdvKTGWFTMEYEIRLKSEEADEWEIHFT--GHQTQFKVFDLYPGQKYLV 199
Cdd:cd00063    1 PSPPTNLRVTD----VTSTSVTLSWTPPE----DDGGPITGYVVEYREKGSGDWKEVEVtpGSETSYTLTGLKPGTEYEF 72

                         90       100
                 ....*....|....*....|
gi 254675324 200 QTRCKPDHGyWSRWGQEKSI 219
Cdd:cd00063   73 RVRAVNGGG-ESPPSESVTV 91
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 122-209 2.37e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 45.68  E-value: 2.37e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675324   122 PEPPRNLTLEVKQlkdkKTYLWVKWLPPTITDvkTGWFTMEYEIRLKSEEADEWEIHFTGHQTQFKVFDLYPGQKYLVQT 201
Cdd:smart00060   1 PSPPSNLRVTDVT----STSVTLSWEPPPDDG--ITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRV 74


                   ....*...
gi 254675324   202 RCKPDHGY 209
Cdd:smart00060  75 RAVNGAGE 82
fn3 pfam00041
Fibronectin type III domain;
124-211 2.08e-05

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 43.17  E-value: 2.08e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675324  124 PPRNLTLEVKQlkdkKTYLWVKWLPPTITDVK-TGwftmeYEIRLKSEEADEWEIHFT--GHQTQFKVFDLYPGQKYL-- 198
Cdd:pfam00041   2 APSNLTVTDVT----STSLTVSWTPPPDGNGPiTG-----YEVEYRPKNSGEPWNEITvpGTTTSVTLTGLKPGTEYEvr 72

                          90
                  ....*....|...
gi 254675324  199 VQTRCKPDHGYWS 211
Cdd:pfam00041  73 VQAVNGGGEGPPS 85
 
Name Accession Description Interval E-value
EpoR_lig-bind pfam09067
Erythropoietin receptor, ligand binding; Members of this family interact with erythropoietin ...
 18-115 3.03e-33

Erythropoietin receptor, ligand binding; Members of this family interact with erythropoietin (EPO), with subsequent initiation of the downstream chain of events associated with binding of EPO to the receptor, including EPO-induced erythroblast proliferation and differentiation through induction of the JAK2/STAT5 signaling cascade. The domain adopts a secondary structure composed of a short amino-terminal helix, followed by two beta-sandwich regions.


Pssm-ID: 401127  Cd Length: 104  Bit Score: 122.53  E-value: 3.03e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675324   18 NGQSPPGKPEIHKCRSPDKETFTCWWNPGSDGGLPTNYSLTYSKEGEkNTYECPDYKTSGPNS-----CFFSKQYTSIWK 92
Cdd:pfam09067   3 AALLLPEKPEDIKCFSREKEDFTCFWEEEEDGGLPTTYSFSYAYENE-TVKECPLYSTSGANStrlfiCFFPKNDVSLFV 81

                          90       100
                  ....*....|....*....|...
gi 254675324   93 IYIITVNATNEMGSSTSDPLYVD 115
Cdd:pfam09067  82 PLHITVVATNTNGTRYSRELSVE 104
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 122-219 1.45e-06

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 46.72  E-value: 1.45e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675324 122 PEPPRNLTLEVkqlkDKKTYLWVKWLPPTitdvKTGWFTMEYEIRLKSEEADEWEIHFT--GHQTQFKVFDLYPGQKYLV 199
Cdd:cd00063    1 PSPPTNLRVTD----VTSTSVTLSWTPPE----DDGGPITGYVVEYREKGSGDWKEVEVtpGSETSYTLTGLKPGTEYEF 72

                         90       100
                 ....*....|....*....|
gi 254675324 200 QTRCKPDHGyWSRWGQEKSI 219
Cdd:cd00063   73 RVRAVNGGG-ESPPSESVTV 91
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 122-209 2.37e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 45.68  E-value: 2.37e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675324   122 PEPPRNLTLEVKQlkdkKTYLWVKWLPPTITDvkTGWFTMEYEIRLKSEEADEWEIHFTGHQTQFKVFDLYPGQKYLVQT 201
Cdd:smart00060   1 PSPPSNLRVTDVT----STSVTLSWEPPPDDG--ITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRV 74


                   ....*...
gi 254675324   202 RCKPDHGY 209
Cdd:smart00060  75 RAVNGAGE 82
fn3 pfam00041
Fibronectin type III domain;
124-211 2.08e-05

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 43.17  E-value: 2.08e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675324  124 PPRNLTLEVKQlkdkKTYLWVKWLPPTITDVK-TGwftmeYEIRLKSEEADEWEIHFT--GHQTQFKVFDLYPGQKYL-- 198
Cdd:pfam00041   2 APSNLTVTDVT----STSLTVSWTPPPDGNGPiTG-----YEVEYRPKNSGEPWNEITvpGTTTSVTLTGLKPGTEYEvr 72

                          90
                  ....*....|...
gi 254675324  199 VQTRCKPDHGYWS 211
Cdd:pfam00041  73 VQAVNGGGEGPPS 85
IL6Ra-bind pfam09240
Interleukin-6 receptor alpha chain, binding; Members of this family adopt a structure ...
 41-109 1.08e-04

Interleukin-6 receptor alpha chain, binding; Members of this family adopt a structure consisting of an immunoglobulin-like beta-sandwich, with seven strands in two beta-sheets, in a Greek-key topology. They are required for binding to the cytokine Interleukin-6.


Pssm-ID: 401252  Cd Length: 96  Bit Score: 41.63  E-value: 1.08e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 254675324   41 CWWNPGSDGGLPTNYSLTYSKEGEKNTYECPDYKTSGPNSCFFSKQYTSI----WKIYIITVNATNEMGSSTS 109
Cdd:pfam09240  14 CEWKPGPNAPPDTNYVLYVRKSPLGPVLQCQYYIRDDGTRIGCQFDDLEGlsssFHQVYICVNGSSSAGPIRS 86
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH